Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmethylated histone binding

JMJD7 SPIN2B SPIN2A SPIN4 SPIN3

2.54e-0886215GO:0035064
GeneOntologyMolecularFunctionmethylation-dependent protein binding

JMJD7 SPIN2B SPIN2A SPIN4 SPIN3

2.85e-0888215GO:0140034
GeneOntologyMolecularFunctionsphingosine N-acyltransferase activity

CERS2 CERS5 CERS6

3.50e-087213GO:0050291
GeneOntologyMolecularFunctionmodification-dependent protein binding

JMJD7 SPIN2B SPIN2A SPIN4 SPIN3

1.98e-06206215GO:0140030
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC17A4 SLC6A4 SLC17A5 MFSD2A

6.64e-06119214GO:0015294
GeneOntologyMolecularFunctionhistone binding

JMJD7 SPIN2B SPIN2A SPIN4 SPIN3

6.78e-06265215GO:0042393
GeneOntologyMolecularFunctionsymporter activity

SLC17A4 SLC6A4 SLC17A5 MFSD2A

1.66e-05150214GO:0015293
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC17A4 SLC6A4 MFSD2A

8.11e-0581213GO:0015370
GeneOntologyMolecularFunctionN-acyltransferase activity

CERS2 CERS5 CERS6

1.61e-04102213GO:0016410
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC17A4 SLC6A4 SLC17A5 MFSD2A

2.32e-04296214GO:0015291
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC17A4 SLC6A4 SLC17A5 MFSD2A

2.47e-04301214GO:0022853
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC17A4 SLC6A4 SLC17A5 CACNA1S MFSD2A

4.02e-04627215GO:0022890
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC17A4 SLC6A4 SLC17A5 CACNA1S MFSD2A

5.23e-04664215GO:0008324
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC17A4 SLC6A4 MFSD2A

7.33e-04171213GO:0015081
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC17A4 SLC6A4 SLC17A5 CACNA1S MFSD2A

9.53e-04758215GO:0015318
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC17A4 SLC6A4 SLC17A5 CACNA1S MFSD2A

1.17e-03793215GO:0015075
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC17A4 SLC6A4 CACNA1S MFSD2A

1.27e-03465214GO:0046873
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC17A4 SLC6A4 SLC17A5 MFSD2A

1.39e-03477214GO:0022804
GeneOntologyMolecularFunctioncarbohydrate derivative transmembrane transporter activity

SLC17A5 MFSD2A

1.74e-0359212GO:1901505
GeneOntologyMolecularFunctionacyltransferase activity, transferring groups other than amino-acyl groups

CERS2 CERS5 CERS6

1.90e-03238213GO:0016747
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC17A4 SLC6A4 SLC17A5 CACNA1S MFSD2A

6.57e-031180215GO:0022857
GeneOntologyMolecularFunctionacyltransferase activity

CERS2 CERS5 TRIP12 CERS6

7.95e-03775214GO:0016746
GeneOntologyMolecularFunctiontransporter activity

SLC17A4 SLC6A4 SLC17A5 CACNA1S MFSD2A

9.49e-031289215GO:0005215
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

SLC17A4 SLC6A4

1.38e-02171212GO:0015103
GeneOntologyBiologicalProcessceramide biosynthetic process

CERS2 CERS5 CERS6

5.40e-0573213GO:0046513
GeneOntologyBiologicalProcessceramide metabolic process

CERS2 CERS5 CERS6

1.98e-04113213GO:0006672
GeneOntologyBiologicalProcesssphingolipid biosynthetic process

CERS2 CERS5 CERS6

2.20e-04117213GO:0030148
GeneOntologyBiologicalProcessphosphatidylcholine biosynthetic process

MFSD2A CHKA

4.22e-0430212GO:0006656
GeneOntologyBiologicalProcessphosphatidylethanolamine metabolic process

MFSD2A CHKA

4.22e-0430212GO:0046337
GeneOntologyBiologicalProcessmembrane lipid biosynthetic process

CERS2 CERS5 CERS6

5.20e-04157213GO:0046467
GeneOntologyBiologicalProcessamide biosynthetic process

CERS2 CERS5 CERS6

6.79e-04172213GO:0043604
GeneOntologyBiologicalProcesssphingolipid metabolic process

CERS2 CERS5 CERS6

7.25e-04176213GO:0006665
GeneOntologyBiologicalProcesslipid biosynthetic process

CERS2 CERS5 MFSD2A CERS6 CHKA

1.13e-03813215GO:0008610
GeneOntologyCellularComponentendoplasmic reticulum membrane

CERS2 CERS5 UGT2B17 WFS1 MFSD2A CERS6

1.34e-031293216GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

CERS2 CERS5 UGT2B17 WFS1 MFSD2A CERS6

1.37e-031299216GO:0098827
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

CERS2 CERS5 UGT2B17 WFS1 MFSD2A CERS6

1.53e-031327216GO:0042175
DomainSPIN/Ssty

SPIN2B SPIN2A SPIN4 SPIN3

5.90e-125214IPR003671
DomainSpin-Ssty

SPIN2B SPIN2A SPIN4 SPIN3

5.90e-125214PF02513
DomainTLC

CERS2 CERS5 TLCD3A CERS6

2.13e-0916214PS50922
DomainTLC-dom

CERS2 CERS5 TLCD3A CERS6

2.13e-0916214IPR006634
DomainTRAM_LAG1_CLN8

CERS2 CERS5 TLCD3A CERS6

2.13e-0916214PF03798
DomainTLC

CERS2 CERS5 TLCD3A CERS6

2.13e-0916214SM00724
DomainLag1/Lac1

CERS2 CERS5 CERS6

2.44e-086213IPR016439
DomainSPIN-2

SPIN2B SPIN2A

1.20e-062212IPR029564
DomainMFS

SLC17A4 SLC17A5 MFSD2A

8.49e-0577213IPR011701
DomainMFS_1

SLC17A4 SLC17A5 MFSD2A

8.49e-0577213PF07690
DomainMFS

SLC17A4 SLC17A5 MFSD2A

2.32e-04108213PS50850
DomainMFS_dom

SLC17A4 SLC17A5 MFSD2A

4.37e-04134213IPR020846
DomainHomeobox

CERS2 CERS5 CERS6

2.19e-03234213PF00046
DomainHOMEOBOX_1

CERS2 CERS5 CERS6

2.24e-03236213PS00027
DomainHOX

CERS2 CERS5 CERS6

2.27e-03237213SM00389
DomainHomeobox_dom

CERS2 CERS5 CERS6

2.32e-03239213IPR001356
DomainHOMEOBOX_2

CERS2 CERS5 CERS6

2.32e-03239213PS50071
Domain-

CERS2 CERS5 CERS6

3.74e-032832131.10.10.60
DomainHomeodomain-like

CERS2 CERS5 CERS6

5.84e-03332213IPR009057
PathwayWP_SYNTHESIS_OF_CERAMIDES_AND_1DEOXYCERAMIDES

CERS2 CERS5 CERS6

1.19e-0622143M45544
PathwayWP_SPHINGOLIPID_METABOLISM_INTEGRATED_PATHWAY

CERS2 CERS5 CERS6

2.00e-0626143MM15892
PathwayWP_SPHINGOLIPID_METABOLISM_INTEGRATED_PATHWAY

CERS2 CERS5 CERS6

2.00e-0626143M39784
PathwayREACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS

CERS2 CERS5 CERS6

2.25e-0627143MM14646
PathwayWP_SPHINGOLIPID_PATHWAY

CERS2 CERS5 CERS6

3.12e-0630143M39501
PathwayREACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS

CERS2 CERS5 CERS6

5.94e-0637143M554
PathwayREACTOME_SPHINGOLIPID_METABOLISM

CERS2 CERS5 CERS6

9.29e-0592143MM15086
PathwayREACTOME_SPHINGOLIPID_METABOLISM

CERS2 CERS5 CERS6

1.46e-04107143M14857
PathwayREACTOME_METABOLISM_OF_LIPIDS

CERS2 CERS5 MFSD2A CERS6 CHKA

2.33e-04620145MM15193
PathwayWP_SPHINGOLIPID_METABOLISM_OVERVIEW

CERS2 CERS6

2.71e-0425142MM15931
PathwayREACTOME_SYNTHESIS_OF_PC

MFSD2A CHKA

2.94e-0426142MM14584
PathwayWP_SPHINGOLIPID_METABOLISM_OVERVIEW

CERS2 CERS6

3.17e-0427142M39863
PathwayREACTOME_SYNTHESIS_OF_PC

MFSD2A CHKA

3.41e-0428142M684
PathwayREACTOME_METABOLISM_OF_LIPIDS

CERS2 CERS5 MFSD2A CERS6 CHKA

5.88e-04757145M27451
Pubmed

A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1.

SPIN2B SPIN2A SPIN4 SPIN3

1.47e-12621429061846
Pubmed

Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells.

CERS2 CERS5 CERS6

1.90e-10321320406683
Pubmed

Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.

CERS2 CERS5 CERS6

1.90e-09521315823095
Pubmed

Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region.

CERS2 CERS5 CERS6

1.90e-09521326887952
Pubmed

Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine.

CERS2 CERS5 CERS6

3.79e-09621317977534
Pubmed

Oxidized phospholipids induce ceramide accumulation in RAW 264.7 macrophages: role of ceramide synthases.

CERS2 CERS5 CERS6

3.79e-09621323936132
Pubmed

Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis.

CERS2 CERS5 CERS6

1.06e-08821336543979
Pubmed

A new functional motif in Hox domain-containing ceramide synthases: identification of a novel region flanking the Hox and TLC domains essential for activity.

CERS5 CERS6

3.47e-07221217609214
Pubmed

Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with roles in cell cycle progression.

SPIN2B SPIN2A

3.47e-07221212145692
Pubmed

Generation of a ceramide synthase 6 mouse lacking the DDRSDIE C-terminal motif.

CERS5 CERS6

3.47e-07221235849604
Pubmed

Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression.

CERS2 CERS6

3.47e-07221219912991
Pubmed

Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development.

CERS2 CERS5 CERS6

5.50e-072721323096701
Pubmed

Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil.

CERS2 CERS5 CERS6

5.50e-072721325269881
Pubmed

Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2.

CERS2 CERS5 CERS6

6.86e-072921338485951
Pubmed

Eleven residues determine the acyl chain specificity of ceramide synthases.

CERS2 CERS5

1.04e-06321229632068
Pubmed

CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity.

CERS5 CERS6

1.04e-06321231150623
Pubmed

Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer.

CERS2 CERS6

1.04e-06321234915026
Pubmed

Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors.

CERS5 CERS6

2.08e-06421212912983
Pubmed

The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS.

CERS2 CERS6

2.08e-06421223538298
Pubmed

SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY.

CERS2 CERS6

2.08e-06421226620563
Pubmed

Do longevity assurance genes containing Hox domains regulate cell development via ceramide synthesis?

CERS5 CERS6

2.08e-06421212297269
Pubmed

PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels.

CERS2 CERS5

3.47e-06521238961186
Pubmed

Sex-specific perturbation of complex lipids in response to medium-chain fatty acids in very long-chain acyl-CoA dehydrogenase deficiency.

CERS2 CERS5

7.28e-06721231971349
Pubmed

Histone methylation mediated by NSD1 is required for the establishment and maintenance of neuronal identities.

WFS1 CACNA1S

1.21e-042721237995181
Pubmed

Bcl2L13 is a ceramide synthase inhibitor in glioblastoma.

CERS2 CERS6

1.70e-043221224706805
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

CERS5 TRIP12 WFS1 CERS6 TM9SF3

2.04e-0494221531073040
Pubmed

Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development.

CERS2 CERS6

2.28e-043721229044125
InteractionHTR2C interactions

CERS2 CERS5 CERS6 TM9SF3

9.09e-06130214int:HTR2C
InteractionP2RY1 interactions

CERS2 CERS6 TM9SF3

1.35e-0545213int:P2RY1
InteractionSYVN1 interactions

SLC6A4 CERS2 WFS1 TLCD3A TM9SF3

1.72e-05324215int:SYVN1
InteractionP2RY12 interactions

CERS5 CERS6 TM9SF3

3.54e-0562213int:P2RY12
InteractionVIPR2 interactions

CERS2 CERS5 WFS1 CERS6

4.38e-05194214int:VIPR2
InteractionLPAR1 interactions

CERS2 CERS5 CERS6 TM9SF3

5.97e-05210214int:LPAR1
InteractionDEFB107A interactions

SPIN2B SPIN3

8.01e-0513212int:DEFB107A
InteractionPRDM7 interactions

SPIN2A SPIN3

9.34e-0514212int:PRDM7
InteractionC3AR1 interactions

CERS2 CERS5 CERS6

1.48e-04100213int:C3AR1
InteractionCMKLR1 interactions

CERS2 CERS6 TM9SF3

1.52e-04101213int:CMKLR1
InteractionOPRL1 interactions

CERS2 CERS6 TM9SF3

1.57e-04102213int:OPRL1
InteractionTSPAN15 interactions

CERS2 WFS1 CERS6 TM9SF3

1.71e-04276214int:TSPAN15
InteractionCDY2A interactions

SPIN2A SPIN3

2.15e-0421212int:CDY2A
InteractionIPPK interactions

CERS2 CERS5 CERS6

2.29e-04116213int:IPPK
InteractionGPR84 interactions

WFS1 CERS6

3.31e-0426212int:GPR84
InteractionS1PR4 interactions

CERS2 CERS6 TM9SF3

3.74e-04137213int:S1PR4
CytobandXp11.1

SPIN2B SPIN2A

1.20e-064212Xp11.1
CytobandEnsembl 112 genes in cytogenetic band chrXp11

SPIN2B SPIN2A SPIN3

6.55e-04377213chrXp11
GeneFamilyTudor domain containing|Spindlin family

SPIN2B SPIN2A SPIN4 SPIN3

1.53e-1251541089
GeneFamilyCERS class homeoboxes

CERS2 CERS5 CERS6

9.23e-096153530
GeneFamilyTudor domain containing

SPIN2B SPIN2A SPIN4 SPIN3

1.99e-0837154780
GeneFamilyEndogenous ligands|Minor histocompatibility antigens

UGT2B17 APOBEC3B

8.00e-0451152870
GeneFamilySolute carriers

SLC17A4 SLC6A4 SLC17A5

3.87e-03395153752
CoexpressionGSE14308_TH17_VS_INDUCED_TREG_DN

SLC6A4 CERS5 MFSD2A CERS6

1.78e-05200214M3386
ToppCellkidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CERS2 CERS6 TM9SF3

4.18e-0514521347a3bb973a508d3097213a2d86ad1ce697af9bae
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

TUBGCP5 TLCD3A SPIN3

6.25e-0516621389e2b8453180983533faccb4275867861876d7ee
ToppCelldroplet-Liver-Npc-18m-Lymphocytic-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JMJD7 SPIN2A TUBGCP5

7.68e-0517821309d2687e0d79f12e90af35fc1c0453d249cf2d19
ToppCellmild-Lymphocytic-Plasmablast|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

UGT2B17 WFS1 APOBEC3B

8.75e-05186213060510c21b1e0889b7a6eeb15821b9e2f03a0f99
ToppCelldroplet-Spleen-nan-24m-Lymphocytic-plasma_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC17A5 WFS1 CACNA1S

9.32e-05190213992539c380576bf810c00a5f926cf1ee7d57dcf5
ToppCellASK452-Epithelial-Type_1|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

SLC6A4 WFS1 APOBEC3B

1.07e-0419921348cafe44951908d03f3c6f3e185e9cbb86fb5b3b
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Stem_cells-Neuroepithelial_cell|GW23 / Sample Type, Dataset, Time_group, and Cell type.

SLC17A4 TLCD3A APOBEC3B

1.08e-04200213c9c832f489629b8724501ddfede984b41a7b674d
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Stem_cells|GW23 / Sample Type, Dataset, Time_group, and Cell type.

SLC17A4 TLCD3A APOBEC3B

1.08e-04200213d7832ab1ed0ff0a6f7e3ac11b2095dc72c90af44
ToppCellmLN-(7)_Mast_cell-(70)_Mast|mLN / shred on region, Cell_type, and subtype

SPIN2A SPIN4 MFSD2A

1.08e-04200213a6c258cae678be581b1d85cf3446c65c34b13499
ToppCellmLN-Mast_cell-Mast|mLN / Region, Cell class and subclass

SPIN2A SPIN4 MFSD2A

1.08e-0420021381ea6e7a3940277751faf9097b30198159998c7b
ToppCellmLN-Mast_cell|mLN / Region, Cell class and subclass

SPIN2A SPIN4 MFSD2A

1.08e-042002139a5f1d99d8d160923d4d0fbbf9ad48a26f8a4fad
ToppCellmLN-(7)_Mast_cell|mLN / shred on region, Cell_type, and subtype

SPIN2A SPIN4 MFSD2A

1.08e-0420021313bca944fbdbc0be6687eca82c62a4d231ab94f0
Drugscandium phosphate

SPIN2B SPIN2A

8.10e-072212CID006365269
Druglithium indium

SPIN2B SPIN2A

8.10e-072212CID011116062
Drugrubidium nitrate

SPIN2B SPIN2A

8.10e-072212CID000025731
Drugdiphenylketen

SPIN2B SPIN2A

4.86e-064212CID000013696
Drug5-mm AI

SLC6A4 SLC17A5

5.32e-0512212CID000131575
DrugAC1NPP2V

CERS2 CERS5 CERS6

5.71e-0582213CID005207744
DrugVerapamil

SLC6A4 CACNA1S

9.65e-0516212DB00661
DiseaseX-19141 measurement

SLC17A4 UGT2B17

3.75e-0513212EFO_0800799
Diseasemicrocephaly (implicated_via_orthology)

MFSD2A CHKA

2.36e-0432212DOID:10907 (implicated_via_orthology)
Diseaselymphocyte count

SLC6A4 CERS5 TRIP12 CACNA1S MFSD2A CERS6

4.21e-041464216EFO_0004587

Protein segments in the cluster

PeptideGeneStartEntry
MTYDEFEYCWDTFVY

APOBEC3B

336

Q9UH17
IPSQYWYYMIELSFY

CERS2

176

Q96G23
GLYHYYIMELAFYWS

CERS5

186

Q8N5B7
WYDMEYDLKYSYFQL

JMJD7

291

P0C870
YQAFMWALYKYFISF

TUBGCP5

361

Q96RT8
QTYWYLLFYCLFETM

MFSD2A

156

Q8NA29
FAYYYFISFYMLCAF

CACNA1S

1356

Q13698
HFCEWMYDYSYEKYP

CHKA

346

P35790
MWRFSFYLYVFTYGV

CERS6

136

Q6ZMG9
YFCEYWLFYTIMAYT

SLC17A4

301

Q9Y2C5
CYYMNWTYVFYFFGT

SLC17A5

221

Q9NRA2
WFYITYEKDPVLYMY

SPIN2A

161

Q99865
WFYITYEKDPVLYMY

SPIN3

161

Q5JUX0
WFYITYEKDPVLYMY

SPIN4

151

Q56A73
WFYITYEKDPVLYMY

SPIN2B

161

Q9BPZ2
YVWFLIPYMIYDSYA

TLCD3A

76

Q8TBR7
YFIFTSFWAYKIYYV

TM9SF3

466

Q9HD45
YIASYYNTIMAWALY

SLC6A4

171

P31645
ISRYWYYLYDNAMCK

TRIP12

1481

Q14669
IYMLYFDFWFQAYDL

UGT2B17

216

O75795
FCWFYVYRSEGMKVY

WFS1

646

O76024