Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionextracellular matrix structural constituent

FRAS1 VWF COL19A1 MATN2 CRELD2 TECTA ECM1 ZP1 CRELD1 FBLN2 FBN1 FBN2 HMCN2 MUC2 PRG4 NPNT

9.54e-1418813016GO:0005201
GeneOntologyMolecularFunctioncalcium ion binding

SELP FAT4 STAB2 ENPP2 MATN2 CRELD2 ITGB1 LRP1B TENM2 SVEP1 BMP1 CRELD1 EYS FBLN2 FBN1 FBN2 HMCN2 MEGF8 LRP1 LRP2 LRP4 NOTCH1 NPNT

5.30e-1074913023GO:0005509
GeneOntologyMolecularFunctionscavenger receptor activity

STAB2 ENPP2 LRP1 ENDOU PRG4

7.79e-07271305GO:0005044
GeneOntologyMolecularFunctioncargo receptor activity

STAB2 ENPP2 LRP1B LRP1 LRP2 ENDOU PRG4

1.36e-06851307GO:0038024
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

STAB2 LRP1B LRP1 LRP2

2.94e-06161304GO:0005041
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

STAB2 LRP1B LRP1 LRP2

9.42e-06211304GO:0030228
GeneOntologyMolecularFunctionintegrin binding

SELP VWF ADAM20 ITGB1 SVEP1 FBN1 CCN2 NPNT

1.94e-051751308GO:0005178
GeneOntologyMolecularFunctionextracellular matrix constituent conferring elasticity

FBLN2 FBN1 FBN2

5.68e-05121303GO:0030023
GeneOntologyMolecularFunctionstructural molecule activity

FRAS1 VWF COL19A1 MATN2 CRELD2 TECTA ECM1 ZP1 CRELD1 CRYGA FBLN2 FBN1 FBN2 HMCN2 MUC2 PRG4 NPNT

6.75e-0589113017GO:0005198
GeneOntologyMolecularFunctionstructural molecule activity conferring elasticity

FBLN2 FBN1 FBN2

9.31e-05141303GO:0097493
GeneOntologyMolecularFunctionintegrin binding involved in cell-matrix adhesion

ITGB1 SVEP1

4.15e-0451302GO:0098640
GeneOntologyMolecularFunction1-phosphatidylinositol-4-phosphate 3-kinase activity

PIK3C2A PIK3C2B

8.65e-0471302GO:0035005
GeneOntologyMolecularFunctionpolysaccharide binding

ENPP2 ENDOU PRG4

1.06e-03311303GO:0030247
GeneOntologyMolecularFunctioncoreceptor activity

ITGB1 LRP1 LRP4 RECK

1.25e-03721304GO:0015026
GeneOntologyMolecularFunctionextracellular matrix binding

ITGB1 NTN4 FBLN2 LYPD3

1.32e-03731304GO:0050840
GeneOntologyMolecularFunctionlaminin binding

ITGB1 NTN4 LYPD3

1.39e-03341303GO:0043236
GeneOntologyMolecularFunctionnuclear receptor binding

PRAMEF5 ISL1 OASL LRP2 PRAMEF27 PRAMEF6

1.42e-031871306GO:0016922
GeneOntologyMolecularFunctioncell-matrix adhesion mediator activity

ITGB1 SVEP1

1.47e-0391302GO:0098634
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF527 ZNF658 ZNF165 ZNF195 SRY ISL1 ZNF658B ZNF12 ZNF836 ZNF26 OVOL1 ZNF296 ZNF587 ZNF417 NOTCH1 ZNF681 BRF2 ZNF662

1.49e-03127113018GO:0000987
GeneOntologyMolecularFunction1-phosphatidylinositol-3-kinase activity

PIK3C2A PIK3C2B

2.23e-03111302GO:0016303
GeneOntologyBiologicalProcesscell-substrate adhesion

PCSK5 VWF ENPP2 TECTA ITGB1 SVEP1 NTN4 FBLN2 LRP1 LYPD3 CCN2 NOTCH1 NPNT

2.00e-0641013013GO:0031589
GeneOntologyBiologicalProcessextracellular matrix organization

COL19A1 ERO1A MATN2 ITGB1 TGFB1 BMP1 NTN4 LRP1 CCN2 RECK NOTCH1 NPNT

4.85e-0637713012GO:0030198
GeneOntologyBiologicalProcesstransforming growth factor beta receptor superfamily signaling pathway

SPRY2 ERO1A ACVR1B ITGB1 TGFB1 FBN1 FBN2 MEGF8 WIF1 LRP1 LRP2 NOTCH1 NPNT

4.89e-0644513013GO:0141091
GeneOntologyBiologicalProcessextracellular structure organization

COL19A1 ERO1A MATN2 ITGB1 TGFB1 BMP1 NTN4 LRP1 CCN2 RECK NOTCH1 NPNT

4.99e-0637813012GO:0043062
GeneOntologyBiologicalProcessexternal encapsulating structure organization

COL19A1 ERO1A MATN2 ITGB1 TGFB1 BMP1 NTN4 LRP1 CCN2 RECK NOTCH1 NPNT

5.12e-0637913012GO:0045229
GeneOntologyBiologicalProcesscirculatory system development

PCSK5 SPRY2 FAT4 STAB2 SYNE1 ISL1 ACVR1B ECM1 ITGB1 SVEP1 TGFB1 CRELD1 SMYD4 FBN1 ADRB2 MEGF8 PIK3C2A WIF1 LRP1 LRP2 CCN2 C6 RECK NOTCH1

1.04e-05144213024GO:0072359
GeneOntologyBiologicalProcesscell surface receptor protein serine/threonine kinase signaling pathway

SPRY2 ERO1A ACVR1B ITGB1 TGFB1 FBN1 FBN2 MEGF8 WIF1 LRP1 LRP2 NOTCH1 NPNT

1.15e-0548213013GO:0007178
GeneOntologyBiologicalProcessnegative regulation of ossification

ECM1 TGFB1 ADRB2 LRP4 NOTCH1

1.55e-05501305GO:0030279
GeneOntologyBiologicalProcessenzyme-linked receptor protein signaling pathway

SPRY2 FAT4 ERO1A ANKRD62 ACVR1B ITGB1 SVEP1 TGFB1 FBN1 FBN2 ADRB2 MEGF8 PIK3C2A WIF1 LRP1 LRP2 LRP4 CCN2 NOTCH1 NPNT PLCE1

1.62e-05118613021GO:0007167
GeneOntologyBiologicalProcesskidney development

PCSK5 FAT4 FRAS1 TGFB1 FBN1 OVOL1 LRP2 LRP4 NOTCH1 NPNT PLCE1

2.43e-0537213011GO:0001822
GeneOntologyBiologicalProcessrenal system development

PCSK5 FAT4 FRAS1 TGFB1 FBN1 OVOL1 LRP2 LRP4 NOTCH1 NPNT PLCE1

3.40e-0538613011GO:0072001
GeneOntologyBiologicalProcessvasculature development

PCSK5 SPRY2 STAB2 ISL1 ECM1 ITGB1 SVEP1 TGFB1 ADRB2 MEGF8 PIK3C2A WIF1 LRP1 LRP2 CCN2 C6 RECK NOTCH1

3.77e-0596913018GO:0001944
GeneOntologyBiologicalProcesscardiac muscle cell myoblast differentiation

ISL1 ITGB1 NOTCH1

5.16e-05121303GO:0060379
GeneOntologyBiologicalProcesscell-matrix adhesion

PCSK5 ENPP2 TECTA ITGB1 SVEP1 LRP1 LYPD3 CCN2 NPNT

5.47e-052701309GO:0007160
GeneOntologyBiologicalProcessblood vessel development

PCSK5 SPRY2 STAB2 ISL1 ECM1 ITGB1 TGFB1 ADRB2 MEGF8 PIK3C2A WIF1 LRP1 LRP2 CCN2 C6 RECK NOTCH1

7.58e-0592913017GO:0001568
GeneOntologyBiologicalProcessaxon guidance

MATN2 ISL1 TENM2 NTN4 HMCN2 MEGF8 LRP1 LRP2 NOTCH1

8.29e-052851309GO:0007411
GeneOntologyBiologicalProcesspositive regulation of platelet activation

SELP SVEP1 PEAR1

8.46e-05141303GO:0010572
GeneOntologyBiologicalProcessneuron projection guidance

MATN2 ISL1 TENM2 NTN4 HMCN2 MEGF8 LRP1 LRP2 NOTCH1

8.51e-052861309GO:0097485
GeneOntologyBiologicalProcessheart development

PCSK5 FAT4 SYNE1 ISL1 ACVR1B ITGB1 TGFB1 CRELD1 SMYD4 FBN1 MEGF8 WIF1 LRP1 LRP2 NOTCH1

8.64e-0575713015GO:0007507
GeneOntologyBiologicalProcessregulation of collagen metabolic process

ACVR1B ITGB1 TGFB1 CCN2 NOTCH1

1.26e-04771305GO:0010712
GeneOntologyBiologicalProcessappendage morphogenesis

PCSK5 FRAS1 FBN2 MEGF8 LRP4 RECK NOTCH1

1.74e-041851307GO:0035107
GeneOntologyBiologicalProcesslimb morphogenesis

PCSK5 FRAS1 FBN2 MEGF8 LRP4 RECK NOTCH1

1.74e-041851307GO:0035108
GeneOntologyBiologicalProcesstube development

PCSK5 SPRY2 FAT4 STAB2 MUC19 ISL1 ECM1 ITGB1 TGFB1 FBN1 ADRB2 MEGF8 PIK3C2A LRP1 LRP2 CCN2 C6 RECK CTSZ NOTCH1 NPNT

1.79e-04140213021GO:0035295
GeneOntologyBiologicalProcesscoronary vasculature development

PCSK5 MEGF8 LRP1 LRP2 NOTCH1

1.80e-04831305GO:0060976
GeneOntologyBiologicalProcesscardioblast differentiation

ISL1 ITGB1 NOTCH1

1.86e-04181303GO:0010002
GeneOntologyBiologicalProcessblood vessel morphogenesis

SPRY2 STAB2 ISL1 ECM1 ITGB1 TGFB1 ADRB2 MEGF8 PIK3C2A LRP1 LRP2 CCN2 C6 RECK NOTCH1

1.99e-0481713015GO:0048514
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

ENPP2 SYNE1 MATN2 ISL1 ITGB1 TENM2 RNF157 WDR47 NTN4 HMCN2 MEGF8 LRP1 LRP2 LRP4 NOTCH1

2.05e-0481913015GO:0120039
GeneOntologyBiologicalProcesscardiac septum development

PCSK5 ISL1 CRELD1 LRP1 LRP2 NOTCH1

2.07e-041341306GO:0003279
GeneOntologyBiologicalProcesscell projection morphogenesis

ENPP2 SYNE1 MATN2 ISL1 ITGB1 TENM2 RNF157 WDR47 NTN4 HMCN2 MEGF8 LRP1 LRP2 LRP4 NOTCH1

2.24e-0482613015GO:0048858
GeneOntologyBiologicalProcesssequestering of TGFbeta in extracellular matrix

FBN1 FBN2

2.35e-0441302GO:0035583
GeneOntologyBiologicalProcessubiquitin-dependent protein catabolic process via the N-end rule pathway

UBR2 UBR4

2.35e-0441302GO:0071596
GeneOntologyBiologicalProcesstube morphogenesis

SPRY2 FAT4 STAB2 ISL1 ECM1 ITGB1 TGFB1 ADRB2 MEGF8 PIK3C2A LRP1 LRP2 CCN2 C6 RECK CTSZ NOTCH1 NPNT

2.47e-04112513018GO:0035239
GeneOntologyBiologicalProcessaxonogenesis

MATN2 ISL1 ITGB1 TENM2 WDR47 NTN4 HMCN2 MEGF8 LRP1 LRP2 LRP4 NOTCH1

2.47e-0456613012GO:0007409
GeneOntologyBiologicalProcessembryo development

PCSK5 SPRY2 FRAS1 PRAMEF5 RICTOR ISL1 ACVR1B TECTA ITGB1 LRP1B TGFB1 FBN2 SEC24C LRIG1 MEGF8 LRP2 LRP4 C6 RECK NOTCH1 PRAMEF6

2.51e-04143713021GO:0009790
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

SYNE1 MATN2 ISL1 TECTA ITGB1 TENM2 WDR47 NTN4 HMCN2 MEGF8 LRP1 LRP2 LRP4 NOTCH1

2.70e-0474813014GO:0048667
GeneOntologyBiologicalProcessregulation of ossification

ECM1 TGFB1 FBN2 ADRB2 LRP4 NOTCH1

3.42e-041471306GO:0030278
GeneOntologyBiologicalProcessrespiratory tube development

PCSK5 SPRY2 MUC19 TGFB1 FBN1 CCN2 CTSZ NOTCH1

3.43e-042731308GO:0030323
GeneOntologyBiologicalProcessembryonic limb morphogenesis

FRAS1 FBN2 MEGF8 LRP4 RECK NOTCH1

3.54e-041481306GO:0030326
GeneOntologyBiologicalProcessembryonic appendage morphogenesis

FRAS1 FBN2 MEGF8 LRP4 RECK NOTCH1

3.54e-041481306GO:0035113
GeneOntologyBiologicalProcessregulation of transmembrane receptor protein serine/threonine kinase signaling pathway

SPRY2 ACVR1B TGFB1 FBN1 FBN2 LRP1 LRP2 NOTCH1 NPNT

3.60e-043471309GO:0090092
GeneOntologyBiologicalProcesstransforming growth factor beta receptor signaling pathway

SPRY2 ERO1A ITGB1 TGFB1 FBN1 FBN2 LRP1 NPNT

3.69e-042761308GO:0007179
GeneOntologyBiologicalProcessregulation of mini excitatory postsynaptic potential

SYNE1 ADRB2

3.89e-0451302GO:0061884
GeneOntologyBiologicalProcesspositive regulation of lysosomal protein catabolic process

LRP1 LRP2

3.89e-0451302GO:1905167
GeneOntologyBiologicalProcessmini excitatory postsynaptic potential

SYNE1 ADRB2

3.89e-0451302GO:0098816
GeneOntologyBiologicalProcesschemoattraction of axon

LRP1 LRP2

3.89e-0451302GO:0061642
GeneOntologyBiologicalProcesscardiac chamber development

PCSK5 ISL1 TGFB1 CRELD1 LRP1 LRP2 NOTCH1

3.99e-042121307GO:0003205
GeneOntologyBiologicalProcessdigestive tract development

PCSK5 FAT4 MUC19 TGFB1 MEGF8 NOTCH1

4.08e-041521306GO:0048565
GeneOntologyBiologicalProcessmuscle organ development

COL19A1 ERO1A ISL1 ITGB1 TGFB1 ADRB2 KMT5B LRP2 FHL3 NOTCH1

4.48e-0443613010GO:0007517
GeneOntologyBiologicalProcessphosphatidylinositol-mediated signaling

PIK3C2A PIK3C2B PLCE1

4.49e-04241303GO:0048015
GeneOntologyBiologicalProcesstranscytosis

TG LRP1 LRP2

4.49e-04241303GO:0045056
GeneOntologyBiologicalProcessendocardial cushion development

ISL1 TGFB1 CRELD1 NOTCH1

4.91e-04581304GO:0003197
GeneOntologyBiologicalProcessventricular cardiac muscle tissue morphogenesis

ISL1 TGFB1 LRP2 NOTCH1

5.24e-04591304GO:0055010
GeneOntologyBiologicalProcessneuron projection morphogenesis

SYNE1 MATN2 ISL1 ITGB1 TENM2 RNF157 WDR47 NTN4 HMCN2 MEGF8 LRP1 LRP2 LRP4 NOTCH1

5.43e-0480213014GO:0048812
GeneOntologyBiologicalProcesslimb development

PCSK5 FRAS1 FBN2 MEGF8 LRP4 RECK NOTCH1

5.54e-042241307GO:0060173
GeneOntologyBiologicalProcessappendage development

PCSK5 FRAS1 FBN2 MEGF8 LRP4 RECK NOTCH1

5.54e-042241307GO:0048736
GeneOntologyBiologicalProcessdigestive system development

PCSK5 FAT4 MUC19 TGFB1 MEGF8 NOTCH1

6.71e-041671306GO:0055123
GeneOntologyBiologicalProcessneural precursor cell proliferation

ITGB1 WDR47 TGFB1 PSMG1 CNTNAP4 LRP2 NOTCH1

6.99e-042331307GO:0061351
GeneOntologyBiologicalProcessphosphatidylinositol 3-kinase/protein kinase B signal transduction

SELP SPRY2 RICTOR ITGB1 TGFB1 PIK3C2A PIK3C2B LRP2 PEAR1

7.18e-043821309GO:0043491
GeneOntologyBiologicalProcessmorphogenesis of a branching epithelium

SPRY2 FAT4 TGFB1 NTN4 CTSZ NOTCH1 NPNT

7.54e-042361307GO:0061138
GeneOntologyBiologicalProcessregulation of collagen biosynthetic process

ACVR1B TGFB1 CCN2 NOTCH1

7.58e-04651304GO:0032965
GeneOntologyBiologicalProcessregulation of ERK1 and ERK2 cascade

SPRY2 PRAMEF5 ANKRD62 TGFB1 LRP1 CCN2 NOTCH1 PRAMEF6 NPNT

7.58e-043851309GO:0070372
GeneOntologyBiologicalProcessaxon development

MATN2 ISL1 ITGB1 TENM2 WDR47 NTN4 HMCN2 MEGF8 LRP1 LRP2 LRP4 NOTCH1

7.60e-0464213012GO:0061564
GeneOntologyBiologicalProcessregulation of biomineral tissue development

ECM1 TGFB1 FBN2 ADRB2 NOTCH1

7.81e-041141305GO:0070167
GeneOntologyBiologicalProcesspositive regulation of protein catabolic process in the vacuole

LRP1 LRP2

8.11e-0471302GO:1904352
GeneOntologyBiologicalProcesscellular response to growth factor stimulus

SPRY2 FAT4 ERO1A ACVR1B ITGB1 TGFB1 FBN1 FBN2 MEGF8 LRP1 LRP2 CCN2 NOTCH1 NPNT

9.54e-0485013014GO:0071363
GeneOntologyBiologicalProcessanimal organ morphogenesis

SPRY2 FAT4 FRAS1 MUC19 ISL1 TECTA TGFB1 BMP1 NTN4 FBN2 LRIG1 MEGF8 LRP2 LRP4 CCN2 CTSZ NOTCH1 NPNT

1.02e-03126913018GO:0009887
GeneOntologyBiologicalProcessnegative regulation of biomineral tissue development

ECM1 TGFB1 NOTCH1

1.06e-03321303GO:0070168
GeneOntologyBiologicalProcessglycosaminoglycan catabolic process

STAB2 TGFB1 GNS

1.06e-03321303GO:0006027
GeneOntologyBiologicalProcessmaintenance of protein location in extracellular region

FBN1 FBN2

1.08e-0381302GO:0071694
GeneOntologyBiologicalProcessamyloid-beta clearance by cellular catabolic process

LRP1 LRP4

1.08e-0381302GO:0150094
GeneOntologyBiologicalProcessinner ear development

SPRY2 FAT4 TECTA TGFB1 LRIG1 OTOGL NOTCH1

1.13e-032531307GO:0048839
GeneOntologyBiologicalProcessregulation of cell-substrate adhesion

PCSK5 ENPP2 ITGB1 FBLN2 LRP1 NOTCH1 NPNT

1.16e-032541307GO:0010810
GeneOntologyBiologicalProcessneuron projection development

FAT4 SYNE1 MATN2 ISL1 TECTA ITGB1 TENM2 RNF157 WDR47 NTN4 HMCN2 ZNF296 MEGF8 OTOGL LRP1 LRP2 LRP4 NOTCH1

1.18e-03128513018GO:0031175
GeneOntologyBiologicalProcessregulation of cellular response to growth factor stimulus

SPRY2 ITGB1 TGFB1 FBN1 FBN2 LRP1 LRP2 NOTCH1 NPNT

1.22e-034121309GO:0090287
GeneOntologyCellularComponentextracellular matrix

FRAS1 VWF COL19A1 MATN2 TECTA ECM1 ITGB1 SVEP1 TGFB1 ZP1 BMP1 CRELD1 NTN4 EYS FBLN2 FBN1 FBN2 FCGBP HMCN2 LRIG1 OTOGL CCN2 MUC2 PRG4 CTSZ NPNT

3.65e-1465613026GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

FRAS1 VWF COL19A1 MATN2 TECTA ECM1 ITGB1 SVEP1 TGFB1 ZP1 BMP1 CRELD1 NTN4 EYS FBLN2 FBN1 FBN2 FCGBP HMCN2 LRIG1 OTOGL CCN2 MUC2 PRG4 CTSZ NPNT

3.92e-1465813026GO:0030312
GeneOntologyCellularComponentcollagen-containing extracellular matrix

FRAS1 VWF COL19A1 MATN2 ECM1 ITGB1 TGFB1 ZP1 BMP1 CRELD1 NTN4 EYS FBLN2 FBN1 FBN2 HMCN2 CCN2 MUC2 PRG4 CTSZ NPNT

1.39e-1153013021GO:0062023
GeneOntologyCellularComponentbasement membrane

FRAS1 MATN2 ITGB1 NTN4 FBN1 HMCN2 NPNT

1.13e-051221307GO:0005604
GeneOntologyCellularComponentGolgi lumen

PCSK5 ERO1A MUC19 MUC13 TGFB1 MUC2

6.18e-051091306GO:0005796
GeneOntologyCellularComponentcoated vesicle

VWF ADRB2 ERGIC3 SEC24C PIK3C2A CNIH4 LRP1 LRP2 CTSZ

4.27e-043601309GO:0030135
HumanPhenoAbnormality of external features of the abdomen

FRAS1 ISL1 TG TGFB1 FOCAD BMP1 KMT2C FBN1 SEC24C MEGF8 TRIM8 LRP2 NOTCH1

5.92e-073264013HP:0001462
HumanPhenoUmbilical hernia

FRAS1 ISL1 TG FOCAD BMP1 KMT2C FBN1 SEC24C MEGF8 TRIM8 LRP2 NOTCH1

2.17e-063064012HP:0001537
HumanPhenoAbnormal umbilicus morphology

FRAS1 ISL1 TG FOCAD BMP1 KMT2C FBN1 SEC24C MEGF8 TRIM8 LRP2 NOTCH1

2.75e-063134012HP:0001551
HumanPhenoHernia of the abdominal wall

FAT4 FRAS1 ISL1 TG FOCAD BMP1 CRELD1 KMT2C FBN1 SEC24C MEGF8 TRIM8 LRP2 GNS NOTCH1

2.82e-065064015HP:0004299
HumanPhenoAbdominal wall defect

FAT4 FRAS1 ISL1 TG FOCAD BMP1 CRELD1 KMT2C FBN1 SEC24C MEGF8 TRIM8 LRP2 GNS NOTCH1

3.20e-065114015HP:0010866
HumanPhenoThoracoabdominal wall defect

FAT4 FRAS1 ISL1 TG FOCAD BMP1 CRELD1 KMT2C FBN1 SEC24C MEGF8 TRIM8 LRP2 GNS NOTCH1

3.20e-065114015HP:0100656
HumanPhenoAbnormality of the abdominal wall

FAT4 FRAS1 ISL1 TG FOCAD BMP1 CRELD1 KMT2C FBN1 SEC24C MEGF8 TRIM8 LRP2 GNS NOTCH1

1.00e-055604015HP:0004298
HumanPhenoAbnormal hip bone morphology

FAT4 FRAS1 TG TGFB1 BMP1 CRELD1 FBN1 FBN2 MEGF8 PIK3C2A TRIM8 LRP1 LRP4 CCN2 PRG4 GNS

1.41e-056534016HP:0003272
HumanPhenoHernia

FAT4 FRAS1 ISL1 TG FOCAD BMP1 CRELD1 KMT2C FBN1 SEC24C MEGF8 TRIM8 LRP2 GNS NOTCH1

1.86e-055894015HP:0100790
HumanPhenoAbnormal pelvic girdle bone morphology

FAT4 FRAS1 TG TGFB1 BMP1 CRELD1 FBN1 FBN2 MEGF8 PIK3C2A TRIM8 LRP1 LRP4 CCN2 PRG4 GNS

5.82e-057304016HP:0002644
HumanPhenoAbnormal upper to lower segment ratio

FBN1 FBN2

1.79e-043402HP:0012772
HumanPhenoAbnormal sternum morphology

FRAS1 SYNE1 NARS1 SRY BMP1 CRELD1 FBN1 FBN2 MEGF8 PIK3C2A LRP2 LRP4

1.81e-044744012HP:0000766
MousePhenoabnormal limb development

PCSK5 FRAS1 ITGB1 FBN2 MEGF8 LRP1 LRP4 RECK

8.84e-061401038MP:0006279
DomainEGF-like_dom

SELP PCSK5 CNTNAP3B FAT4 FRAS1 STAB2 ADAM20 MATN2 CNTNAP3 CRELD2 MUC13 TECTA LRP1B TENM2 VWDE SVEP1 BMP1 CRELD1 EYS FBLN2 FBN1 FBN2 FCGBP HMCN2 MEGF8 WIF1 LRP1 CNTNAP4 LRP2 LRP4 C6 NOTCH1 NPNT PEAR1

9.56e-3524912934IPR000742
DomainEGF

SELP PCSK5 CNTNAP3B FAT4 FRAS1 STAB2 MATN2 CNTNAP3 CRELD2 MUC13 TECTA LRP1B TENM2 VWDE SVEP1 BMP1 CRELD1 EYS FBLN2 FBN1 FBN2 FCGBP MEGF8 WIF1 LRP1 CNTNAP4 LRP2 LRP4 NOTCH1 NPNT PEAR1

3.61e-3123512931SM00181
DomainEGF_1

SELP CNTNAP3B FAT4 STAB2 ADAM20 CNTNAP3 CRELD2 MUC13 ITGB1 LRP1B TENM2 VWDE SVEP1 BMP1 CRELD1 NTN4 EYS FBLN2 FBN1 FBN2 HMCN2 MEGF8 WIF1 LRP1 CNTNAP4 LRP2 LRP4 C6 NOTCH1 NPNT PEAR1

4.85e-3025512931PS00022
DomainEGF-like_CS

SELP FAT4 STAB2 ADAM20 MATN2 CNTNAP3 CRELD2 MUC13 ITGB1 LRP1B TENM2 VWDE SVEP1 BMP1 CRELD1 NTN4 EYS FBLN2 FBN1 FBN2 HMCN2 MEGF8 WIF1 LRP1 CNTNAP4 LRP2 LRP4 C6 NOTCH1 NPNT PEAR1

1.01e-2926112931IPR013032
DomainEGF_3

SELP CNTNAP3B FAT4 STAB2 ADAM20 MATN2 CNTNAP3 CRELD2 MUC13 LRP1B TENM2 VWDE SVEP1 BMP1 CRELD1 EYS FBLN2 FBN1 FBN2 HMCN2 MEGF8 WIF1 LRP1 CNTNAP4 LRP2 LRP4 C6 NOTCH1 NPNT PEAR1

1.01e-2923512930PS50026
DomainEGF_2

SELP CNTNAP3B FAT4 STAB2 ADAM20 MATN2 CNTNAP3 CRELD2 MUC13 LRP1B TENM2 VWDE SVEP1 BMP1 CRELD1 EYS FBLN2 FBN1 FBN2 HMCN2 MEGF8 WIF1 LRP1 CNTNAP4 LRP2 LRP4 C6 NOTCH1 NPNT PEAR1

4.00e-2826512930PS01186
DomainGrowth_fac_rcpt_

PCSK5 FAT4 FRAS1 STAB2 MATN2 CRELD2 MUC13 LRP1B SVEP1 BMP1 CRELD1 NTN4 EYS FBLN2 FBN1 FBN2 HMCN2 MEGF8 LRP1 LRP2 LRP4 CCN2 NOTCH1 NPNT

7.56e-2615612924IPR009030
DomainEGF_CA

FAT4 STAB2 MATN2 CRELD2 LRP1B TENM2 SVEP1 BMP1 CRELD1 EYS FBLN2 FBN1 FBN2 HMCN2 MEGF8 LRP1 LRP2 LRP4 NOTCH1 NPNT

3.11e-2212212920SM00179
DomainEGF-like_Ca-bd_dom

FAT4 STAB2 MATN2 CRELD2 LRP1B TENM2 SVEP1 BMP1 CRELD1 EYS FBLN2 FBN1 FBN2 HMCN2 MEGF8 LRP1 LRP2 LRP4 NOTCH1 NPNT

4.38e-2212412920IPR001881
DomainASX_HYDROXYL

FAT4 MATN2 CRELD2 LRP1B SVEP1 BMP1 CRELD1 EYS FBLN2 FBN1 FBN2 HMCN2 MEGF8 LRP1 LRP2 LRP4 NOTCH1 NPNT

7.17e-2110012918PS00010
DomainEGF_CA

FAT4 MATN2 CRELD2 LRP1B SVEP1 BMP1 CRELD1 FBLN2 FBN1 FBN2 HMCN2 MEGF8 LRP1 LRP2 LRP4 NOTCH1 NPNT

1.67e-208612917PF07645
DomainEGF-type_Asp/Asn_hydroxyl_site

FAT4 MATN2 CRELD2 LRP1B SVEP1 BMP1 CRELD1 EYS FBLN2 FBN1 FBN2 HMCN2 MEGF8 LRP1 LRP2 LRP4 NOTCH1 NPNT

2.18e-2010612918IPR000152
DomainEGF_Ca-bd_CS

FAT4 CRELD2 LRP1B SVEP1 BMP1 CRELD1 EYS FBLN2 FBN1 FBN2 HMCN2 MEGF8 LRP1 LRP2 LRP4 NOTCH1 NPNT

1.49e-199712917IPR018097
DomainEGF_CA

FAT4 CRELD2 LRP1B SVEP1 BMP1 CRELD1 EYS FBLN2 FBN1 FBN2 HMCN2 MEGF8 LRP1 LRP2 LRP4 NOTCH1 NPNT

2.14e-199912917PS01187
DomainEGF

SELP STAB2 MATN2 CNTNAP3 TECTA LRP1B SVEP1 BMP1 EYS WIF1 LRP1 CNTNAP4 LRP2 LRP4 NOTCH1

9.10e-1512612915PF00008
DomaincEGF

MATN2 LRP1B FBLN2 FBN1 FBN2 LRP1 LRP2 LRP4

5.85e-12261298PF12662
DomaincEGF

MATN2 LRP1B FBLN2 FBN1 FBN2 LRP1 LRP2 LRP4

5.85e-12261298IPR026823
DomainTIL_dom

VWF MUC19 TECTA FCGBP LRP2 MUC2

2.77e-10141296IPR002919
DomainVWF_type-D

VWF MUC19 TECTA VWDE FCGBP MUC2

7.31e-10161296IPR001846
DomainVWFD

VWF MUC19 TECTA VWDE FCGBP MUC2

7.31e-10161296PS51233
DomainVWD

VWF MUC19 TECTA VWDE FCGBP MUC2

7.31e-10161296SM00216
DomainVWD

VWF MUC19 TECTA VWDE FCGBP MUC2

7.31e-10161296PF00094
DomainVWC_out

FRAS1 VWF MUC19 TECTA FCGBP MUC2

2.43e-09191296SM00215
DomainVWC

FRAS1 VWF MUC19 TECTA FCGBP CCN2 MUC2

6.72e-09381297SM00214
DomainC8

VWF MUC19 TECTA FCGBP MUC2

1.11e-08121295PF08742
DomainTIL

VWF MUC19 TECTA FCGBP MUC2

1.11e-08121295PF01826
DomainVWF_dom

FRAS1 VWF MUC19 TECTA FCGBP CCN2 MUC2

1.40e-08421297IPR001007
DomainUnchr_dom_Cys-rich

VWF MUC19 TECTA FCGBP MUC2

1.79e-08131295IPR014853
DomainC8

VWF MUC19 TECTA FCGBP MUC2

1.79e-08131295SM00832
DomainhEGF

FAT4 SVEP1 EYS FBN2 WIF1 NOTCH1

3.21e-08281296PF12661
DomainEGF_extracell

STAB2 ITGB1 LRP1B SVEP1 WIF1 LRP2 NOTCH1

1.81e-07601297IPR013111
DomainEGF_2

STAB2 ITGB1 LRP1B SVEP1 WIF1 LRP2 NOTCH1

1.81e-07601297PF07974
DomainVWFC_2

FRAS1 VWF MUC19 TECTA CCN2 MUC2

2.22e-07381296PS50184
DomainLaminin_EGF

STAB2 CRELD2 CRELD1 NTN4 MEGF8 PEAR1

2.22e-07381296IPR002049
Domain-

LRP1B TENM2 LRP1 LRP2 LRP4 HHIPL1

2.61e-073912962.120.10.30
DomainLdl_recept_a

LDLRAD1 LRP1B LRP1 LRP2 LRP4 C6

6.31e-07451296PF00057
Domain6-blade_b-propeller_TolB-like

LRP1B TENM2 LRP1 LRP2 LRP4 HHIPL1

7.21e-07461296IPR011042
DomainLDLRA_1

LDLRAD1 LRP1B LRP1 LRP2 LRP4 C6

9.34e-07481296PS01209
DomainLDrepeatLR_classA_rpt

LDLRAD1 LRP1B LRP1 LRP2 LRP4 C6

1.06e-06491296IPR002172
DomainLDLa

LDLRAD1 LRP1B LRP1 LRP2 LRP4 C6

1.06e-06491296SM00192
DomainLDLRA_2

LDLRAD1 LRP1B LRP1 LRP2 LRP4 C6

1.06e-06491296PS50068
DomainLdl_recept_b

LRP1B LRP1 LRP2 LRP4

2.06e-06141294PF00058
DomainLDLRB

LRP1B LRP1 LRP2 LRP4

2.06e-06141294PS51120
DomainLY

LRP1B LRP1 LRP2 LRP4

2.80e-06151294SM00135
DomainLDLR_classB_rpt

LRP1B LRP1 LRP2 LRP4

2.80e-06151294IPR000033
DomainLaminin_G

CNTNAP3B FAT4 COL19A1 CNTNAP3 EYS CNTNAP4

2.91e-06581296IPR001791
DomainSomatomedin_B_chordata

ENPP2 ENDOU PRG4

3.19e-0651293IPR020436
DomainLAM_G_DOMAIN

CNTNAP3B FAT4 CNTNAP3 EYS CNTNAP4

6.08e-06381295PS50025
DomainCTCK_1

VWF MUC19 CCN2 MUC2

6.17e-06181294PS01185
DomainFurin_repeat

PCSK5 FRAS1 CRELD2 CRELD1

6.17e-06181294IPR006212
DomainFU

PCSK5 FRAS1 CRELD2 CRELD1

6.17e-06181294SM00261
DomainLDLR_class-A_CS

LRP1B LRP1 LRP2 LRP4 C6

7.88e-06401295IPR023415
DomainLaminin_G_2

CNTNAP3B FAT4 CNTNAP3 EYS CNTNAP4

7.88e-06401295PF02210
DomainLamG

CNTNAP3B FAT4 CNTNAP3 EYS CNTNAP4

1.27e-05441295SM00282
DomainCT

VWF MUC19 CCN2 MUC2

1.44e-05221294SM00041
Domain-

LDLRAD1 LRP1B LRP1 LRP2 LRP4

1.59e-054612954.10.400.10
DomainSomatomedin_B

ENPP2 ENDOU PRG4

1.76e-0581293PF01033
DomainCys_knot_C

VWF MUC19 CCN2 MUC2

2.46e-05251294IPR006207
DomainCTCK_2

VWF MUC19 CCN2 MUC2

2.46e-05251294PS01225
DomainSO

ENPP2 ENDOU PRG4

2.62e-0591293SM00201
DomainSomatomedin_B_dom

ENPP2 ENDOU PRG4

3.73e-05101293IPR001212
DomainSMB_1

ENPP2 ENDOU PRG4

3.73e-05101293PS00524
DomainSMB_2

ENPP2 ENDOU PRG4

3.73e-05101293PS50958
DomainDUF5050

LRP1B LRP1

4.73e-0521292IPR032485
DomainDUF5050

LRP1B LRP1

4.73e-0521292PF16472
Domain-

FAT4 COL19A1 CNTNAP3 SVEP1 EYS CNTNAP4

5.08e-059512962.60.120.200
DomainVWF_A

VWF MATN2 ITGB1 SVEP1 HMCN2 SEC24C

6.40e-05991296IPR002035
DomainEGF_Lam

STAB2 NTN4 MEGF8 PEAR1

9.63e-05351294SM00180
DomainLaminin_EGF

CRELD1 NTN4 MEGF8 PEAR1

9.63e-05351294PF00053
DomainVWFC_1

FRAS1 VWF CCN2 MUC2

1.08e-04361294PS01208
DomainTILa_dom

TECTA FCGBP

1.41e-0431292IPR025615
DomainTILa

TECTA FCGBP

1.41e-0431292PF12714
DomainFBN

FBN1 FBN2

1.41e-0431292IPR011398
DomainConA-like_dom

CNTNAP3B FAT4 COL19A1 CNTNAP3 SVEP1 EYS CNTNAP4 NPNT

1.42e-042191298IPR013320
Domain-

VWF MATN2 ITGB1 SVEP1 SEC24C

1.60e-047412953.40.50.410
DomainKRAB

ZNF527 ZNF658 ZNF195 ZNF12 ZNF836 ZNF26 ZNF587 ZNF417 ZNF681 ZNF662

1.93e-0435812910PS50805
DomainKRAB

ZNF527 ZNF658 ZNF195 ZNF12 ZNF836 ZNF26 ZNF587 ZNF417 ZNF681 ZNF662

2.46e-0436912910SM00349
DomainKRAB

ZNF527 ZNF658 ZNF195 ZNF12 ZNF836 ZNF26 ZNF587 ZNF417 ZNF681 ZNF662

2.51e-0437012910IPR001909
DomainVWFA

VWF MATN2 ITGB1 SVEP1 HMCN2

2.59e-04821295PS50234
DomainPRAME_family

PRAMEF5 PRAMEF27 PRAMEF6

2.88e-04191293IPR026271
DomainVWA

VWF MATN2 ITGB1 SVEP1 HMCN2

2.90e-04841295SM00327
Domainzf-C2H2_6

ZNF527 ZNF658 ZNF195 ZNF12 ZNF836 ZNF26 ZNF587 ZNF417 ZNF681

3.36e-043141299PF13912
DomainFA58C

CNTNAP3B CNTNAP3 CNTNAP4

3.91e-04211293SM00231
DomainFA58C_3

CNTNAP3B CNTNAP3 CNTNAP4

3.91e-04211293PS50022
DomainFA58C_1

CNTNAP3B CNTNAP3 CNTNAP4

3.91e-04211293PS01285
DomainFA58C_2

CNTNAP3B CNTNAP3 CNTNAP4

3.91e-04211293PS01286
DomainGalactose-bd-like

PCSK5 CNTNAP3B CNTNAP3 NTN4 CNTNAP4

4.88e-04941295IPR008979
DomainF5_F8_type_C

CNTNAP3B CNTNAP3 CNTNAP4

5.86e-04241293PF00754
DomainFA58C

CNTNAP3B CNTNAP3 CNTNAP4

5.86e-04241293IPR000421
DomainEphrin_rec_like

PCSK5 SVEP1 TG

6.62e-04251293SM01411
DomainTyr-kin_ephrin_A/B_rcpt-like

PCSK5 SVEP1 TG

6.62e-04251293IPR011641
Domain-

ZNF527 ZNF658 ZNF165 ZNF195 ZNF12 ZNF836 ZNF26 OVOL1 ZNF296 ZNF587 ZNF417 ZNF681 ZNF662

8.49e-04679129133.30.160.60
DomainKRAB

ZNF527 ZNF658 ZNF195 ZNF12 ZNF836 ZNF26 ZNF587 ZNF417 ZNF681

8.61e-043581299PF01352
DomainVWC

FRAS1 VWF CCN2

9.29e-04281293PF00093
DomainZINC_FINGER_C2H2_2

ZNF527 ZNF658 ZNF165 ZNF195 ZNF12 ZNF836 ZNF26 OVOL1 ZNF296 ZNF587 HELZ2 ZNF417 ZNF681 ZNF662

9.41e-0477512914PS50157
DomainZINC_FINGER_C2H2_1

ZNF527 ZNF658 ZNF165 ZNF195 ZNF12 ZNF836 ZNF26 OVOL1 ZNF296 ZNF587 HELZ2 ZNF417 ZNF681 ZNF662

9.64e-0477712914PS00028
DomainPI3K_Ras-bd_dom

PIK3C2A PIK3C2B

9.72e-0471292IPR000341
DomainDUF3456

CRELD2 CRELD1

9.72e-0471292PF11938
DomainTB

FBN1 FBN2

9.72e-0471292PF00683
DomainPI3K_rbd

PIK3C2A PIK3C2B

9.72e-0471292SM00144
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

ITGB1 TGFB1 FBLN2 FBN1 FBN2

1.58e-0632895MM14854
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

ITGB1 TGFB1 FBLN2 FBN1 FBN2

3.33e-0637895M27134
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

ITGB1 TGFB1 FBLN2 FBN1 FBN2

4.35e-0639895MM14601
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

ITGB1 TGFB1 FBLN2 FBN1 FBN2

8.01e-0644895M26969
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

VWF COL19A1 ITGB1 TGFB1 BMP1 NTN4 FBLN2 FBN1 FBN2 LRP4

1.89e-053008910M610
PathwayWP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES

STAB2 ARV1 ENPP2 LRP1B PIK3C2A LRP1 LRP2 LRP4 ENDOU HHIPL1 PRG4

2.69e-053818911M48063
PathwayWP_CELLS_AND_MOLECULES_INVOLVED_IN_LOCAL_ACUTE_INFLAMMATORY_RESPONSE

SELP ITGB1 C6

1.55e-0417893M39733
PathwayBIOCARTA_LAIR_PATHWAY

SELP ITGB1 C6

1.55e-0417893M3952
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

VWF COL19A1 ITGB1 TGFB1 BMP1 FBLN2 FBN1 FBN2

2.22e-04258898MM14572
PathwayREACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS

MUC19 MUC13 MUC2

2.98e-0421893MM15706
PathwayWP_CARDIAC_PROGENITOR_DIFFERENTIATION

ISL1 TGFB1 BMP1 NOTCH1

3.43e-0453894M39681
PathwayWP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE

FBN1 FBN2 CCN2

5.06e-0425893M39713
PathwayREACTOME_FERTILIZATION

IZUMO4 ADAM20 ZP1

5.69e-0426893M26922
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

UBR2 FAT4 FRAS1 ARV1 ERO1A MATN2 CNTNAP3 CRELD2 ECM1 ITGB1 LRP1B TGFB1 BMP1 CRELD1 FBN1 FBN2 ERGIC3 SEC24C MEGF8 CNIH4 PSMG1 LRP1 LRP4 CCN2 GNS CTSZ NOTCH1

6.20e-1412011312735696571
Pubmed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

VWF MATN2 CRELD2 ECM1 BMP1 CRELD1 FBLN2 FBN1 FBN2 HMCN2 CTSZ

7.18e-111751311128071719
Pubmed

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

VWF COL19A1 MATN2 ECM1 FBLN2 FBN1 MUC2 PRG4 CTSZ NPNT

3.69e-101531311025037231
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

SPRY2 VWF ENPP2 TNPO2 SYNE1 UBR4 NARS1 LRP1B WDR47 FOCAD ZNF836 FBN1 PSMG1 WIF1 TRIM8 LRP1 LRP2 LRP4 CCN2 RECK ZMYM5 ZNF662

2.88e-0912851312235914814
Pubmed

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.

PCSK5 VWF MATN2 ECM1 SVEP1 BMP1 FBLN2 FBN1 CCN2 PRG4 NPNT

2.90e-092481311124006456
Pubmed

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.

SELP ITGB1 LRP1B ADRB2 TAS1R2 LRP1 LRP2 NOTCH1

4.92e-09101131823382219
Pubmed

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.

FRAS1 VWF MATN2 ECM1 FBLN2 FBN1 HMCN2 MUC2 NPNT

1.57e-08167131922159717
Pubmed

Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation.

TGFB1 FBN1 FBN2

5.22e-083131320855508
Pubmed

RECK-Mediated β1-Integrin Regulation by TGF-β1 Is Critical for Wound Contraction in Mice.

ITGB1 TGFB1 RECK

5.22e-083131326247610
Pubmed

LRP2 mediates folate uptake in the developing neural tube.

LRP1B LRP1 LRP2 LRP4

6.22e-0811131424639464
Pubmed

Interrupting TGF-β1/CCN2/integrin-α5β1 signaling alleviates high mechanical-stress caused chondrocyte fibrosis.

ITGB1 TGFB1 CCN2

2.08e-074131333629293
Pubmed

Extracellular microfibrils control osteoblast-supported osteoclastogenesis by restricting TGF{beta} stimulation of RANKL production.

TGFB1 FBN1 FBN2

2.08e-074131320729550
Pubmed

Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.

PCSK5 VWF MATN2 FBN1 MEGF8 LRP1 NOTCH1

3.41e-07118131721078624
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

UBR2 FRAS1 SYNE1 KIAA0232 TENM2 RNF157 WDR47 FOCAD SEC24C MEGF8 PLCE1

4.45e-074071311112693553
Pubmed

The Notch intracellular domain integrates signals from Wnt, Hedgehog, TGFβ/BMP and hypoxia pathways.

TGFB1 BMP1 NOTCH1

5.19e-075131326592459
Pubmed

Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.

LRP1 LRP2 LRP4

5.19e-075131319047013
Pubmed

Creb5 coordinates synovial joint formation with the genesis of articular cartilage.

FAT4 WIF1 CCN2 PRG4

7.13e-0719131436435829
Pubmed

BMP1 controls TGFbeta1 activation via cleavage of latent TGFbeta-binding protein.

TGFB1 BMP1 FBN1

1.04e-066131317015622
Pubmed

MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.

LRP1B LRP1 LRP2 LRP4

1.09e-0621131421337463
Pubmed

Protein interactome reveals converging molecular pathways among autism disorders.

SPRY2 VWF KIAA0232 CRELD2 ECM1 CRELD1 FBLN2 FBN1 MEGF8 FHL3 L3MBTL3 NOTCH1

1.51e-065601311221653829
Pubmed

Putative functions of extracellular matrix glycoproteins in secondary palate morphogenesis.

TGFB1 FBN1 FBN2

2.88e-068131323055981
Pubmed

Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci.

ZNF195 TG TGFB1 LMO1 ZNF681

3.53e-066113158662221
Pubmed

Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.

VWF FBN1 FBN2

4.31e-069131312122015
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

CRISP2 SPRY2 FAT4 TNPO2 UBR4 MUC19 NARS1 ACVR1B FOCAD KMT2C LRP2 C6 PRG4

4.53e-067361311329676528
Pubmed

Mutation of LRP1 in cardiac neural crest cells causes congenital heart defects by perturbing outflow lengthening.

ISL1 BMP1 LRP1 NOTCH1

5.59e-0631131432546759
Pubmed

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

ECM1 ITGB1 TGFB1 FCGBP MEGF8 LRP1 C6 PRG4

6.30e-06257131816335952
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

ACVR1B FBN1 FBN2 LRP1 LRP2

7.49e-0671131533541421
Pubmed

Tracing the origin of hair follicle stem cells.

FBN2 LMO1 WIF1 LRP4

9.19e-0635131434108685
Pubmed

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.

DPP6 STAB2 COL19A1 LRP1B EYS KMT5B RECK

1.11e-05199131723382691
Pubmed

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

VWF MATN2 CRELD1 FBN1 FBN2 NPNT

1.28e-05135131628675934
Pubmed

Lower expression of Hsa_circRNA_102682 in diabetic hyperhomocysteinemia negatively related to creatinemia is associated with TGF-β and CTGF.

TGFB1 CCN2

1.41e-052131234296783
Pubmed

Striking differences of LDL receptor-related protein 1B expression in mouse and human.

LRP1B LRP1

1.41e-052131215963947
Pubmed

Confocal laser scanning analysis of the association of fibulin-2 with fibrillin-1 and fibronectin define different stages of skin regeneration.

FBLN2 FBN1

1.41e-05213129886271
Pubmed

An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death.

TGFB1 FBN1

1.41e-052131227893734
Pubmed

New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.

FBN1 FBN2

1.41e-052131230044367
Pubmed

[Proliferation effect of ligamentum flavum cells induced by transforming growth factor β 1 and its effect on connective tissue growth factor].

TGFB1 CCN2

1.41e-052131231298008
Pubmed

Activation of beta1 integrins on blood eosinophils by P-selectin.

SELP ITGB1

1.41e-052131221441381
Pubmed

MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.

FBN1 FBN2

1.41e-052131215131124
Pubmed

Q-switched 1064 nm Nd: YAG laser restores skin photoageing by activating autophagy by TGFβ1 and ITGB1.

ITGB1 TGFB1

1.41e-052131238284200
Pubmed

Roles of transforming growth factor-β and phosphatidylinositol 3-kinase isoforms in integrin β1-mediated bio-behaviors of mouse lung telocytes.

ITGB1 TGFB1

1.41e-052131231888636
Pubmed

Microfibril structure masks fibrillin-2 in postnatal tissues.

FBN1 FBN2

1.41e-052131220404337
Pubmed

Fibrillln mutations in Marfan syndrome and related phenotypes.

FBN1 FBN2

1.41e-05213128791520
Pubmed

cDNA microarray analysis of adaptive changes after renal ablation in a sclerosis-resistant mouse strain.

TGFB1 CCN2

1.41e-052131217890868
Pubmed

Modulation of the transforming growth factor-beta1-induced Smad phosphorylation by the extracellular matrix receptor beta1-integrin.

ITGB1 TGFB1

1.41e-052131219885568
Pubmed

Low density lipoprotein receptor-related protein-1 promotes beta1 integrin maturation and transport to the cell surface.

ITGB1 LRP1

1.41e-052131214699139
Pubmed

Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.

FBN1 FBN2

1.41e-05213127744963
Pubmed

Integrative Genomics Analysis Identifies ACVR1B as a Candidate Causal Gene of Emphysema Distribution.

ACVR1B TGFB1

1.41e-052131230335480
Pubmed

Caspr3-Deficient Mice Exhibit Low Motor Learning during the Early Phase of the Accelerated Rotarod Task.

CNTNAP3B CNTNAP3

1.41e-052131226807827
Pubmed

Fibrillin microfibrils in bone physiology.

FBN1 FBN2

1.41e-052131226408953
Pubmed

Connective tissue growth factor mediates transforming growth factor β-induced collagen expression in human endometrial stromal cells.

TGFB1 CCN2

1.41e-052131230695033
Pubmed

Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.

FBN1 FBN2

1.41e-052131218006876
Pubmed

Transforming growth factor-β (TGF-β) expression is increased in the subsynovial connective tissues of patients with idiopathic carpal tunnel syndrome.

TGFB1 CCN2

1.41e-052131224014274
Pubmed

Exome sequencing identified new mutations in a Marfan syndrome family.

FBN1 LRP1

1.41e-052131224484584
Pubmed

Identification and Characterization of Potential Biomarkers by Quantitative Tissue Proteomics of Primary Lung Adenocarcinoma.

ERO1A NARS1

1.41e-052131227161446
Pubmed

[Mechanism of p38 mitogen activated protein kinase signaling pathway on promoting the hypertrophy of human lumbar ligamentum flavum via transforming growth factor β 1/connective tissue growth factor].

TGFB1 CCN2

1.41e-052131231198002
Pubmed

Immobilized metal affinity chromatography co-purifies TGF-β1 with histidine-tagged recombinant extracellular proteins.

TGFB1 FBN1

1.41e-052131223119075
Pubmed

Differential role of von Willebrand factor and P-selectin on microvascular thrombosis in endotoxemia.

SELP VWF

1.41e-052131218802014
Pubmed

Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome.

TGFB1 FBN1

1.41e-052131212598898
Pubmed

RECK inhibits stemness gene expression and tumorigenicity of gastric cancer cells by suppressing ADAM-mediated Notch1 activation.

RECK NOTCH1

1.41e-052131223881612
Pubmed

Targeting transforming growth factor (TGF)-betaRI inhibits activation of beta1 integrin and blocks vascular invasion in hepatocellular carcinoma.

ITGB1 TGFB1

1.41e-052131219115199
Pubmed

The critical role of ASD-related gene CNTNAP3 in regulating synaptic development and social behavior in mice.

CNTNAP3B CNTNAP3

1.41e-052131231150793
Pubmed

Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects.

LRP1 LRP2

1.41e-052131234445520
Pubmed

The involvement of TGF-β1 and CTGF in regional gingival overgrowth.

TGFB1 CCN2

1.41e-052131222395513
Pubmed

Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.

FBN1 FBN2

1.41e-052131212524050
Pubmed

Notch1 Signaling Contributes to Hypoxia-induced High Expression of Integrin β1 in Keratinocyte Migration.

ITGB1 NOTCH1

1.41e-052131228266574
Pubmed

Connective tissue growth factor mediates mouse spermatogonial migration associated with differentiation.

ITGB1 CCN2

1.41e-052131232240712
Pubmed

The complete cDNA sequence and structural polymorphism of the polypeptide chain of porcine submaxillary mucin.

VWF MUC2

1.41e-05213129407109
Pubmed

Expression of transforming growth factor-β1 and connective tissue growth factor in congenital biliary atresia and neonatal hepatitis liver tissue.

TGFB1 CCN2

1.41e-052131226909983
Pubmed

Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.

FBN1 FBN2

1.41e-05213128120105
Pubmed

The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.

FBN1 FBN2

1.41e-052131235419902
Pubmed

Connective tissue growth factor: a crucial cytokine-mediating cardiac fibrosis in ongoing enterovirus myocarditis.

TGFB1 CCN2

1.41e-052131217846733
Pubmed

Fibrillin assembly: dimer formation mediated by amino-terminal sequences.

FBN1 FBN2

1.41e-052131210504303
Pubmed

Activation of the connective tissue growth factor (CTGF)-transforming growth factor β 1 (TGF-β 1) axis in hepatitis C virus-expressing hepatocytes.

TGFB1 CCN2

1.41e-052131223056332
Pubmed

Small interfering RNAs (siRNAs) targeting TGF-beta1 mRNA suppress asbestos-induced expression of TGF-beta1 and CTGF in fibroblasts.

TGFB1 CCN2

1.41e-052131219817698
Pubmed

Tgf-beta auto-induction and connective tissue growth factor expression in human renal tubule epithelial cells requires N-ras.

TGFB1 CCN2

1.41e-052131219494553
Pubmed

Connective tissue growth factor promotes retinal pigment epithelium mesenchymal transition via the PI3K/AKT signaling pathway.

TGFB1 CCN2

1.41e-052131233760200
Pubmed

The class II phosphoinositide 3-kinases PI3K-C2α and PI3K-C2β differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells.

PIK3C2A PIK3C2B

1.41e-052131230374841
Pubmed

Fibrillin-1 regulates the bioavailability of TGFbeta1.

TGFB1 FBN1

1.41e-052131217242066
Pubmed

Convergent signaling in the regulation of connective tissue growth factor in malignant mesothelioma: TGFβ signaling and defects in the Hippo signaling cascade.

TGFB1 CCN2

1.41e-052131222918238
Pubmed

TGFbeta stimulated re-epithelialisation is regulated by CTGF and Ras/MEK/ERK signalling.

TGFB1 CCN2

1.41e-052131217915216
Pubmed

Rictor/mTORC2 signaling mediates TGFβ1-induced fibroblast activation and kidney fibrosis.

RICTOR TGFB1

1.41e-052131225970154
Pubmed

Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.

FBN1 FBN2

1.41e-052131225524144
Pubmed

TGF-β1 Up-Regulates Connective Tissue Growth Factor Expression in Human Granulosa Cells through Smad and ERK1/2 Signaling Pathways.

TGFB1 CCN2

1.41e-052131225955392
Pubmed

Fibrillins 1 and 2 perform partially overlapping functions during aortic development.

FBN1 FBN2

1.41e-052131216407178
Pubmed

A microfibril assembly assay identifies different mechanisms of dominance underlying Marfan syndrome, stiff skin syndrome and acromelic dysplasias.

TGFB1 FBN1

1.41e-052131225979247
Pubmed

Transforming growth factor β induces expression of connective tissue growth factor in hepatic progenitor cells through Smad independent signaling.

TGFB1 CCN2

1.41e-052131223727026
Pubmed

Microvesicles from stored red blood cells induce P-selectin and von Willebrand factor release from endothelial cells via a protein kinase C-dependent mechanism.

SELP VWF

1.41e-052131238355315
Pubmed

N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.

FBN1 FBN2

1.41e-052131210359653
Pubmed

P-selectin anchors newly released ultralarge von Willebrand factor multimers to the endothelial cell surface.

SELP VWF

1.41e-052131214630802
Pubmed

The interactions of TGF-beta signalling pathway and Jagged2/Notch1 pathway induce acanthosis in lingual epithelia.

TGFB1 NOTCH1

1.41e-052131225203837
Pubmed

Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.

FBN1 FBN2

1.41e-052131212399449
Pubmed

Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.

FBN1 FBN2

1.41e-052131221851253
Pubmed

High glucose-induced Matrilin-2 expression in mouse mesangial cells was mediated by transforming growth factor beta 1 (TGF-β1).

MATN2 TGFB1

1.41e-052131227105914
Pubmed

Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.

FBN1 FBN2

1.41e-052131221440062
Pubmed

Identification, genomic organization and mRNA expression of CRELD1, the founding member of a unique family of matricellular proteins.

CRELD2 CRELD1

1.41e-052131212137942
Pubmed

Regulation of fibroblast gene expression by keratinocytes in organotypic skin culture provides possible mechanisms for the antifibrotic effect of reepithelialization.

TGFB1 CCN2

1.41e-052131220731800
Pubmed

Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation.

PIK3C2A PIK3C2B

1.41e-052131214563213
Pubmed

Connective tissue growth factor expression after angiotensin II exposure is dependent on transforming growth factor-β signaling via the canonical Smad-dependent pathway in hypertensive induced myocardial fibrosis.

TGFB1 CCN2

1.41e-052131229575960
Pubmed

Loss of LRP1 promotes acquisition of contractile-myofibroblast phenotype and release of active TGF-β1 from ECM stores.

TGFB1 LRP1

1.41e-052131231841706
Pubmed

Association of MLL3 and TGF-β signaling gene polymorphisms with the susceptibility and prognostic outcomes of Stanford type B aortic dissection : MLL3 with TGF-β signal pathway association with Stanford type B AD.

TGFB1 KMT2C

1.41e-052131237226099
InteractionNTN5 interactions

FRAS1 LRP1B VWDE FBN1 FBN2 LRP2 LRP4 NOTCH1

1.26e-12241268int:NTN5
InteractionCFC1 interactions

PCSK5 UBR2 CNTNAP3B FRAS1 UBR4 CNTNAP3 CRELD2 VWDE BMP1 MEGF8 NOTCH1

4.06e-1012612611int:CFC1
InteractionFBXO2 interactions

PCSK5 CNTNAP3B FRAS1 CNTNAP3 ITGB1 LRP1B RNF157 TGFB1 BMP1 FBN1 FBN2 LRIG1 MEGF8 LRP2 GNS CTSZ NOTCH1

7.96e-1041112617int:FBXO2
InteractionIGFL3 interactions

PCSK5 FRAS1 LRP1B VWDE TGFB1 FBN2 LRP2 LRP4 NOTCH1

9.70e-10751269int:IGFL3
InteractionZFP41 interactions

FRAS1 CRELD2 LRP1B FBN1 FBN2 LRP1 LRP2 LRP4

2.38e-09571268int:ZFP41
InteractionHOXA1 interactions

PCSK5 SPRY2 VWF CRELD2 TGFB1 CRELD1 NTN4 FBLN2 FBN1 MEGF8 ZNF587 TRIM8 FHL3 ZNF417 NOTCH1

6.62e-0935612615int:HOXA1
InteractionTRGV3 interactions

CNTNAP3B FRAS1 UBR4 CNTNAP3 VWDE BMP1 MEGF8

4.99e-08551267int:TRGV3
InteractionLYPD6B interactions

UBR2 LYPD6B UBR4 ZNF195 VWDE FCGBP

1.46e-07391266int:LYPD6B
InteractionZNF408 interactions

FRAS1 KIAA0232 LRP1B CRELD1 FBLN2 FBN1 FBN2 LRP2 LRP4

3.25e-071451269int:ZNF408
InteractionMFAP5 interactions

VWF ARV1 KIAA0232 VWDE FBN1 FBN2

8.52e-07521266int:MFAP5
InteractionEDN3 interactions

ZNF195 CRELD2 VWDE TGFB1 BMP1 MEGF8 NOTCH1

5.22e-061081267int:EDN3
InteractionIGFBP4 interactions

UBR2 VWDE BMP1 MEGF8 NOTCH1

5.52e-06411265int:IGFBP4
InteractionZNF224 interactions

LRP1B FBN2 LRP2 LRP4

6.53e-06201264int:ZNF224
InteractionLYPD4 interactions

PCSK5 ZNF195 CRELD2 VWDE BMP1 FBN2 PIK3C2A

1.23e-051231267int:LYPD4
InteractionPRG2 interactions

PCSK5 CNTNAP3B FRAS1 CNTNAP3 CRELD2 VWDE TGFB1 BMP1 FBN2 NOTCH1

1.24e-0528512610int:PRG2
InteractionGPIHBP1 interactions

PCSK5 CNTNAP3B FRAS1 CNTNAP3 CRELD2 VWDE BMP1

2.05e-051331267int:GPIHBP1
InteractionZNF354C interactions

RICTOR SRY LMO1 LRP4

3.07e-05291264int:ZNF354C
InteractionINSL5 interactions

PCSK5 UBR2 UBR4 CNTNAP3 LRIG1

3.10e-05581265int:INSL5
InteractionSLURP1 interactions

PCSK5 CNTNAP3B CNTNAP3 CRELD2 TGFB1 BMP1 MEGF8

3.41e-051441267int:SLURP1
InteractionHSPG2 interactions

ECM1 ITGB1 BMP1 FBLN2 FBN1 CCN2

3.49e-05981266int:HSPG2
InteractionADAMTSL4 interactions

PCSK5 SPRY2 TGFB1 NTN4 LMO1 ZNF587 FHL3 ZNF417

6.72e-052171268int:ADAMTSL4
InteractionGREM2 interactions

VWDE BMP1 FBN2 LRP2

8.20e-05371264int:GREM2
InteractionFIBIN interactions

CNTNAP3B CNTNAP3 TGFB1 BMP1 MEGF8

8.26e-05711265int:FIBIN
InteractionIGSF5 interactions

CRELD2 LRP4 NOTCH1

8.26e-05141263int:IGSF5
InteractionRNASE4 interactions

CNTNAP3 LRP1B VWDE

8.26e-05141263int:RNASE4
InteractionVEGFD interactions

FRAS1 UBR4 VWDE NOTCH1

9.12e-05381264int:VEGFD
InteractionLYZL1 interactions

FRAS1 CRELD2 VWDE TGFB1 BMP1 LRIG1

9.86e-051181266int:LYZL1
InteractionCCN2 interactions

TGFB1 LRP1 LRP2 CCN2

1.12e-04401264int:CCN2
InteractionPSG8 interactions

FAT4 FRAS1 VWDE MEGF8

1.23e-04411264int:PSG8
InteractionCACNA1A interactions

PCSK5 VWF MATN2 MEGF8 LRP1 NOTCH1

1.24e-041231266int:CACNA1A
InteractionIL5RA interactions

PCSK5 FRAS1 CNTNAP3 TGFB1 BMP1 MEGF8

1.30e-041241266int:IL5RA
InteractionZDHHC15 interactions

ACVR1B FBN1 FBN2 ERGIC3 LRP1 LRP2

1.35e-041251266int:ZDHHC15
InteractionZNF547 interactions

PCSK5 ZNF587 ZNF417

1.52e-04171263int:ZNF547
InteractionFBLN1 interactions

LYPD6B LDLRAD1 ECM1 ITGB1 FBLN2 CCN2

1.61e-041291266int:FBLN1
InteractionC2CD4B interactions

FAT4 FRAS1 KIAA0232 LRP1B

1.63e-04441264int:C2CD4B
InteractionSIRPD interactions

FRAS1 CRELD2 VWDE MEGF8 NOTCH1

2.05e-04861265int:SIRPD
InteractionCCN6 interactions

FRAS1 CRELD2 NOTCH1

2.15e-04191263int:CCN6
InteractionFOXD4L6 interactions

KIAA0232 LRP1B FBN2 NOTCH1

2.48e-04491264int:FOXD4L6
InteractionDEFB125 interactions

UBR4 FBN2 LRP2

2.52e-04201263int:DEFB125
InteractionNCKAP1L interactions

RICTOR ITGB1 NOTCH1

2.52e-04201263int:NCKAP1L
InteractionTIMP3 interactions

FRAS1 LDLRAD1 UBR4 LRP1B LRP2

2.54e-04901265int:TIMP3
InteractionELSPBP1 interactions

CRELD2 VWDE BMP1 MEGF8 NOTCH1

2.81e-04921265int:ELSPBP1
InteractionFBN1 interactions

SPRY2 FBLN2 FBN1 FBN2

2.90e-04511264int:FBN1
InteractionRLN1 interactions

CNTNAP3B CNTNAP3 LRP1B VWDE LRIG1

2.95e-04931265int:RLN1
InteractionGALNT14 interactions

CNTNAP3 MUC13 MUC2

3.37e-04221263int:GALNT14
InteractionVCAN interactions

SELP ITGB1 FBLN2 FBN1

3.62e-04541264int:VCAN
InteractionZBTB43 interactions

TECTA LMO1 ZNF587 ZNF417

4.16e-04561264int:ZBTB43
InteractionARV1 interactions

LDLRAD1 ARV1 ADRB2 ERGIC3

4.16e-04561264int:ARV1
InteractionNKAPL interactions

RICTOR ZNF587 ZNF417

4.39e-04241263int:NKAPL
GeneFamilyLow density lipoprotein receptors

LRP1B LRP1 LRP2 LRP4

3.46e-0713874634
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF527 ZNF658 ZNF165 ZNF195 ZNF12 ZNF836 ZNF26 OVOL1 ZNF296 ZNF587 ZNF417 ZNF681 ZNF662

3.73e-05718871328
GeneFamilyCD molecules|Mucins

MUC19 MUC13 MUC2

1.34e-0421873648
GeneFamilyPRAME family

PRAMEF5 PRAMEF27 PRAMEF6

2.02e-0424873686
GeneFamilyUbiquitin protein ligase E3 component n-recognins

UBR2 UBR4

4.73e-047872785
GeneFamilyFibulins

FBLN2 HMCN2

6.29e-048872556
GeneFamilyPhosphatidylinositol 3-kinase subunits

PIK3C2A PIK3C2B

6.29e-048872831
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

SELP SVEP1 C6

2.61e-03578731179
CoexpressionNABA_ECM_GLYCOPROTEINS

FRAS1 VWF MATN2 CRELD2 TECTA ECM1 VWDE SVEP1 ZP1 CRELD1 NTN4 FBLN2 FBN1 FBN2 HMCN2 OTOGL CCN2 NPNT

3.24e-1819112918MM17059
CoexpressionNABA_CORE_MATRISOME

FRAS1 VWF COL19A1 MATN2 CRELD2 TECTA ECM1 VWDE SVEP1 ZP1 CRELD1 NTN4 FBLN2 FBN1 FBN2 HMCN2 OTOGL CCN2 PRG4 NPNT

4.63e-1827012920MM17057
CoexpressionNABA_ECM_GLYCOPROTEINS

FRAS1 VWF MATN2 CRELD2 TECTA ECM1 VWDE SVEP1 ZP1 CRELD1 NTN4 EYS FBLN2 FBN1 FBN2 HMCN2 CCN2 NPNT

5.17e-1819612918M3008
CoexpressionNABA_CORE_MATRISOME

FRAS1 VWF COL19A1 MATN2 CRELD2 TECTA ECM1 VWDE SVEP1 ZP1 CRELD1 NTN4 EYS FBLN2 FBN1 FBN2 HMCN2 CCN2 PRG4 NPNT

6.64e-1827512920M5884
CoexpressionNABA_MATRISOME

PCSK5 FRAS1 VWF COL19A1 ADAM20 MATN2 MUC19 CRELD2 MUC13 TECTA ECM1 VWDE SVEP1 TGFB1 ZP1 BMP1 CRELD1 NTN4 FBLN2 FBN1 FBN2 HMCN2 MEGF8 OTOGL WIF1 CCN2 MUC2 PRG4 CTSZ NPNT

1.22e-15100812930MM17056
CoexpressionNABA_MATRISOME

PCSK5 FRAS1 VWF COL19A1 ADAM20 MATN2 MUC19 CRELD2 MUC13 TECTA ECM1 VWDE SVEP1 TGFB1 ZP1 BMP1 CRELD1 NTN4 EYS FBLN2 FBN1 FBN2 HMCN2 MEGF8 WIF1 CCN2 MUC2 PRG4 CTSZ NPNT

1.96e-15102612930M5889
CoexpressionHALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION

MATN2 ECM1 ITGB1 TGFB1 BMP1 FBLN2 FBN1 FBN2 LRP1 CCN2

5.97e-0820012910M5930
CoexpressionMEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3

DPP6 FAT4 COL19A1 ISL1 SVEP1 TGFB1 NTN4 FBLN2 ADRB2 ZNF296 LMO1 KCNH2 WIF1 LRP2 CCN2 FHL3 NOTCH1 NPNT PEAR1

1.34e-06107412919M1941
CoexpressionDI_MARTINO_MATRISOME_HIGHLY_PROLIFERATIVE_HNSCC

ECM1 TGFB1 FBLN2 FBN2

9.00e-06271294M47994
CoexpressionCUI_DEVELOPING_HEART_C3_FIBROBLAST_LIKE_CELL

MATN2 ABCA8 FBLN2 FBN1 LRP1 CCN2

2.53e-051171296M39300
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HRGL2C

DPP6 SPRY2 LRP1B FBLN2 LRIG1 LRP1 TMEM255A NOTCH1 NPNT

3.45e-053251299M39053
CoexpressionONDER_CDH1_TARGETS_2_UP

FAT4 ENPP2 SYNE1 ABCA8 FBN1 LRIG1 CCN2 RECK

4.20e-052571298M13867
CoexpressionTRAVAGLINI_LUNG_ARTERY_CELL

SELP PCSK5 ENPP2 FBLN2 PIK3C2B CYYR1

4.78e-051311296M41662
CoexpressionGSE16450_CTRL_VS_IFNA_6H_STIM_MATURE_NEURON_CELL_LINE_UP

SELP FAT4 ECM1 LRP1B FBLN2 FBN1 KCNH2

5.99e-051991297M7420
CoexpressionHE_LIM_SUN_FETAL_LUNG_C3_OMD_POS_ENDOTHELIAL_CELL

SELP PCSK5 MATN2 CNTNAP3 ABCA8 FBLN2 FBN2 HMCN2 CCN2

6.82e-053551299M45758
CoexpressionSAGIV_CD24_TARGETS_DN

ECM1 ADRB2 OASL TRIM8

7.14e-05451294M15657
CoexpressionKATSANOU_ELAVL1_TARGETS_DN

TNPO2 DYNAP FBN2 FHL3 PRG4 NPNT

9.07e-051471296M2387
CoexpressionINGRAM_SHH_TARGETS_UP

PRAMEF5 FBN1 FBN2 CCN2 PRAMEF27 PRAMEF6

1.26e-041561296MM550
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HRGL3

DPP6 ENPP2 MUC19 LRP1B ABCA8 TGFB1 BMP1 LRIG1 LRP1 LRP2 CCN2

1.31e-0457412911M39056
CoexpressionLIM_MAMMARY_STEM_CELL_UP

ENPP2 MATN2 ITGB1 SVEP1 BMP1 WIF1 LRP1 LRP4 CCN2 RECK

1.34e-0447912910M2573
CoexpressionKATSANOU_ELAVL1_TARGETS_DN

TNPO2 DYNAP FBN2 FHL3 PRG4 NPNT

1.35e-041581296MM934
CoexpressionWINZEN_DEGRADED_VIA_KHSRP

SPRY2 MUC13 NTN4 ADRB2 CCN2

1.38e-041001295M2352
CoexpressionLIM_MAMMARY_STEM_CELL_UP

ENPP2 MATN2 ITGB1 SVEP1 BMP1 WIF1 LRP1 LRP4 CCN2 RECK

1.43e-0448312910MM1082
CoexpressionTRAVAGLINI_LUNG_ALVEOLAR_FIBROBLAST_CELL

ENPP2 ABCA8 SVEP1 CCN2 PRG4 NPNT

1.65e-041641296M41676
CoexpressionAtlasStromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3

SPRY2 ENPP2 MATN2 ECM1 ABCA8 SVEP1 BMP1 FBLN2 FBN1 LRIG1 LRP1 RECK

1.19e-0544512412GSM777043_500
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT4 FRAS1 STAB2 COL19A1 LRP1B FBN2 OTOGL CNTNAP4 LRP2 PLCE1

1.92e-10184131102cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT4 FRAS1 STAB2 COL19A1 LRP1B FBN2 OTOGL CNTNAP4 LRP2 PLCE1

1.92e-1018413110ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT4 FRAS1 STAB2 COL19A1 LRP1B FBN2 OTOGL CNTNAP4 LRP2 PLCE1

1.92e-10184131102b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 CNTNAP3B LYPD6B VWF ENPP2 CNTNAP3 FBLN2 HMCN2 PIK3C2B CYYR1

2.50e-10189131106463890d8dbee4bc198f91628a5f784970de786a
ToppCellLA|World / Chamber and Cluster_Paper

PCSK5 LRP1B ABCA8 SVEP1 FBLN2 FBN1 HMCN2 LRP1 LRP2 PRG4

3.07e-1019313110d4bf89437216baf489ea0239136dcedf3b6714af
ToppCellEndothelial-A-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

SELP CNTNAP3B FAT4 VWF ENPP2 MATN2 PIK3C2B CYYR1 PEAR1

2.24e-091721319a3201773a25832e92dd113fad165f1ecd37f5e91
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3B LYPD6B CNTNAP3 ECM1 EYS HMCN2 WIF1 MUC2 PLCE1

3.68e-09182131908aff7112c9dac0ef5540300516a604782b21169
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 CNTNAP3B LYPD6B VWF ENPP2 FBLN2 PIK3C2B CYYR1 CNTNAP4

5.87e-09192131956b021c297a21dff357531f21e2464f85186106d
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MATN2 ECM1 ABCA8 SVEP1 FBN1 HMCN2 LRP1 CCN2 FHL3

6.14e-091931319dc8e62df6121ee99b156aca6b1b3ae555739b6f2
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MATN2 ECM1 ABCA8 SVEP1 FBN1 HMCN2 LRP1 CCN2 FHL3

6.14e-091931319e2ee077fd381bd906e6b4329f22e7d106e422a7f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 CNTNAP3B LYPD6B VWF ENPP2 FBLN2 HMCN2 PIK3C2B CYYR1

6.72e-0919513196bdef651cf73d7381e5012d0eb3c809138fb6b92
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCSK5 ECM1 ABCA8 SVEP1 FBLN2 FBN1 LRP1 PRG4 TMEM255A

8.02e-0919913191fd7bbb8727607e6507848602a19bc86882ef2d5
ToppCellTracheal-10x5prime-Stromal-Fibroblastic-Fibro_adventitial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PCSK5 ECM1 ABCA8 SVEP1 BMP1 FBLN2 FBN1 LRP1 PRG4

8.38e-09200131974ad0ae592252060ee294d7483327d765a6ba1dd
ToppCellParenchymal-10x3prime_v2-Stromal-Fibroblastic-Fibro_peribronchial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SPRY2 MATN2 ECM1 ABCA8 SVEP1 FBLN2 FBN1 LRP1 CCN2

8.38e-092001319efdf7066b7dd43e35dbc0d2719b75f250cf54af2
ToppCellTracheal-10x5prime-Stromal-Fibroblastic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PCSK5 ECM1 ABCA8 SVEP1 BMP1 FBLN2 FBN1 LRP1 PRG4

8.38e-0920013197ba292c30d915e66ebc8026fa76492cedf64700e
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 MUC19 TECTA LRP1B SVEP1 FBN2 CNTNAP4 LRP2

2.56e-081601318c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 MUC19 TECTA LRP1B SVEP1 FBN2 CNTNAP4 LRP2

2.56e-08160131825c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D175|Adult / Lineage, Cell type, age group and donor

SELP CNTNAP3B VWF MATN2 LRP1B PIK3C2B CYYR1 HHIPL1

5.14e-0817513180a65ddfa8c2e8efb5b5338cf07661cb78157a23c
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

PCSK5 CNTNAP3B LYPD6B ENPP2 FBLN2 FBN1 PIK3C2A PIK3C2B

6.12e-0817913181ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCSK5 CNTNAP3B VWF ENPP2 MATN2 FBLN2 PIK3C2B PEAR1

6.12e-081791318d2db9e70b780643f1e004c41a70464d0abe26088
ToppCellfacs-Pancreas-Exocrine-24m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CNTNAP3 MUC19 LRP1B FCGBP OTOGL WIF1 LYPD3 LRP2

6.39e-08180131872310baeed848f2c483ae986cd73d2fb2cca7feb
ToppCellEndothelial-A-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

SELP CNTNAP3B FAT4 VWF ENPP2 CYYR1 CCN2 PEAR1

7.89e-081851318dee0b7ba2f338f0979d2306aedf52ac35a36b60c
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3B LYPD6B CNTNAP3 ECM1 NTN4 EYS WIF1 PLCE1

8.23e-0818613186379609b7ace80683f5754b16aa77f11b43766ae
ToppCellEndothelial-A-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

SELP CNTNAP3B VWF ENPP2 MATN2 FBLN2 CYYR1 PEAR1

9.30e-08189131804b565855f58ca0f343904d04be657b66e109076
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 VWF MUC13 FBLN2 FBN1 PIK3C2B CYYR1 CNTNAP4

9.30e-081891318b028466fcd36fdeceec752e55a24286a1cd62ae4
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3B LYPD6B CNTNAP3 ECM1 NTN4 EYS WIF1 PLCE1

9.69e-0819013188c9c230a509afaeee50644153974a5642b01a2b8
ToppCell343B-Endothelial_cells-Endothelial-B_(Artery)|343B / Donor, Lineage, Cell class and subclass (all cells)

SELP CNTNAP3B VWF ENPP2 MATN2 PIK3C2B CYYR1 CCN2

1.01e-07191131827a532a35d9e8822014f581fd56c4ca62e39f8fe
ToppCellLPS-antiTNF-Endothelial-Endothelial-Artery|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 FAT4 VWF FBLN2 FBN1 PIK3C2B CYYR1 CNTNAP4

1.01e-0719113184b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCell343B-Endothelial_cells-Endothelial-B_(Artery)-|343B / Donor, Lineage, Cell class and subclass (all cells)

SELP CNTNAP3B VWF ENPP2 MATN2 PIK3C2B CYYR1 CCN2

1.01e-0719113181dfcff08e01e6a695953334342bcfde04ba005ad
ToppCellfacs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP2 MATN2 SVEP1 BMP1 FBLN2 FBN1 LRP1 RECK

1.05e-071921318671d4e1eee5aba03c43dbc98f4b51ce42b3df5d5
ToppCellfacs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP2 MATN2 SVEP1 BMP1 FBLN2 FBN1 LRP1 RECK

1.05e-071921318840a34c1b82d218be999ab5e1bcafd6370d7a4b1
ToppCelldroplet-Fat-Mat-18m-Mesenchymal|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 SPRY2 MATN2 SVEP1 FBLN2 FBN1 LRP1 RECK

1.09e-071931318ebd090d7801480b3cee45caac3d30cc991836769
ToppCelldroplet-Fat-Mat-18m-Mesenchymal-Cd34+|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 SPRY2 MATN2 SVEP1 FBLN2 FBN1 LRP1 RECK

1.09e-07193131822c58032e58730715224d7934968ce92d150b0e8
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP2 MATN2 SVEP1 FBLN2 FBN1 LRP1 CCN2 PRG4

1.09e-0719313180a665531d581d4e3941e29d3f95569da8f166447
ToppCellfacs-MAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 MATN2 ECM1 SVEP1 BMP1 FBLN2 FBN1 LRP1

1.09e-071931318f95b95c58a6edb8a03dd15ae166f47f9f33d8bd6
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP2 KIAA0232 MATN2 UBR4 ISL1 DENND4C BMP1 GNS

1.09e-071931318471e65f02937bc18d7c5facdacdf1df58cf0f839
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP2 KIAA0232 MATN2 UBR4 ISL1 DENND4C BMP1 GNS

1.09e-071931318fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCellfacs-MAT-Fat-3m-Mesenchymal-mesenchymal_progenitor|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 MATN2 ECM1 SVEP1 BMP1 FBLN2 FBN1 LRP1

1.09e-07193131885faf6c5ce4769615a4eca036e2ba307e176bb52
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3B LYPD6B CNTNAP3 ECM1 NTN4 EYS WIF1 PLCE1

1.09e-071931318c4b22b62f3cc7bf0ec0eba76e1504c236290bbc9
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-fibroblast|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP2 MATN2 SVEP1 FBLN2 FBN1 LRP1 CCN2 PRG4

1.09e-07193131824ce1f37cca655415410d2403a52d1ebb3332280
ToppCelldroplet-Fat-Mat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 SPRY2 MATN2 SVEP1 FBLN2 FBN1 LRP1 RECK

1.09e-071931318573ad2f848bede1fe20c7b4b352a9242ec294725
ToppCellfacs-MAT-Fat-3m-Mesenchymal|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 MATN2 ECM1 SVEP1 BMP1 FBLN2 FBN1 LRP1

1.09e-071931318110a7d2ba7d066c2be38be98b643b76c520dd980
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CNTNAP3 MUC19 LRP1B FBN1 FBN2 HMCN2 OTOGL LRP4

1.18e-071951318d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CNTNAP3 MUC19 LRP1B FBN1 FBN2 HMCN2 OTOGL LRP4

1.18e-07195131819853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SELP LYPD6B VWF ENPP2 FBLN2 FBN1 PIK3C2B CYYR1

1.18e-07195131877e47d2e8b3eb7f7c9620369ccaf87581f923bdb
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LYPD6B VWF ENPP2 MATN2 FBLN2 HMCN2 CYYR1 NOTCH1

1.23e-071961318a20a56d8997d6db2a10046c8801c619a379de83c
ToppCellTracheal-10x5prime-Stromal-Peri/Epineurial_|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MATN2 TENM2 ABCA8 RNF157 FBN1 FBN2 LRP1 PEAR1

1.28e-0719713182cb1f557ce1400398975de94638126b4522567f3
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCSK5 ECM1 ABCA8 SVEP1 FBLN2 FBN1 LRP1 PRG4

1.28e-07197131871786e9432e2d649f5d86f639abb25e7102deb67
ToppCelldistal-Endothelial-Artery-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SELP PCSK5 FAT4 VWF ENPP2 FBLN2 CYYR1 CCN2

1.33e-071981318f284f59f4ebe55ee132eddfaa2f5d9ecb059654f
ToppCellILEUM-non-inflamed-(7)_ACKR1+_endothelial_cells|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

SELP CNTNAP3B VWF ENPP2 FBLN2 CYYR1 CCN2 C6

1.33e-071981318f8a6a75c9f2fbe32a22b14b6a029411c73c09f68
ToppCelldistal-Endothelial-Artery|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SELP PCSK5 VWF ENPP2 MATN2 FBLN2 PIK3C2B CYYR1

1.38e-071991318b6e9aaac047d4b64b9d97f5e174e89a424d8b36d
ToppCell(5)_Fibroblast-G|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

DPP6 FRAS1 ABCA8 SVEP1 LRP1 CCN2 PRG4 NPNT

1.38e-071991318b4a737575be9f8c65771832dd8cd25328d5dae0d
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SPRY2 ITGB1 FBN1 FBN2 HMCN2 CNTNAP4 CCN2 PLCE1

1.38e-071991318eeb7d370d4dfacf705306c72ccc4919ddefacff1
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

PCSK5 SYNE1 MATN2 FBN1 KCNH2 WIF1 LRP1 LRP4

1.38e-0719913186b3a0e5d52a30d0eed30e6a670f5b53bc233f70c
ToppCelldistal-2-Endothelial-Artery|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SELP PCSK5 VWF ENPP2 MATN2 FBLN2 PIK3C2B CYYR1

1.38e-071991318fa8aaf7a90699e41a7a4cee5614f8c9248110327
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT4 ECM1 ABCA8 SVEP1 FBLN2 FBN1 LRP1 PRG4

1.38e-071991318fb580e9321ddf97c73b2e356cd82523db74a38a2
ToppCellfacs-Trachea-nan-3m-Mesenchymal|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPRY2 MATN2 BMP1 FBN1 WIF1 LRP1 CCN2 RECK

1.38e-07199131867f78c070c56e44fba36542041bf7fa1c291807c
ToppCellfacs-Trachea-nan-3m-Mesenchymal-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPRY2 MATN2 BMP1 FBN1 WIF1 LRP1 CCN2 RECK

1.38e-0719913181ae244b563f85c1ee8d22698f478c842a4d9c7f5
ToppCelldistal-Endothelial-Artery-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SELP PCSK5 VWF ENPP2 MATN2 FBLN2 PIK3C2B CYYR1

1.38e-0719913183788f3218356aaaa10684e48d63757037f8a3a3c
ToppCellParenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SELP FAT4 VWF ENPP2 MATN2 FBLN2 PIK3C2B CYYR1

1.44e-072001318ac6b8bc9998d303f788511b8f111e682ea9f3df8
ToppCellBronchus_Control_(B.)-Stromal-TX-Fibroblasts-2,_SCARA5|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

FAT4 ECM1 ABCA8 SVEP1 FBLN2 FBN1 PRG4 TMEM255A

1.44e-0720013182022df85df94ab8cbb4e80e3fe9894c01051c5e0
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

PCSK5 FAT4 MATN2 FBN1 KCNH2 WIF1 LRP1 LRP4

1.44e-072001318a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCellcellseq2-Mesenchymal-Fibroblastic-Fibroblastic_1-AF2|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SPRY2 ECM1 ABCA8 SVEP1 FBLN2 FBN1 LRP1 PRG4

1.44e-07200131844317fbf4d1480a37b50ab2777bf1a3e4fc0c05f
ToppCellSkin-Fibroblasts|Skin / Skin and Kidney Cells in Lupus Nephritis Patients.

ECM1 ABCA8 SVEP1 FBLN2 FBN1 WIF1 LRP1 PRG4

1.44e-072001318f777eadf571a1a6d246da87346a9cb9d511c2e81
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SPRY2 FAT4 SYNE1 ABCA8 SVEP1 FBLN2 FBN1 LRP1

1.44e-0720013183dd022e974fec7013ba18f333da63f58fbf2dd7c
ToppCellcellseq2-Mesenchymal-Fibroblastic|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SPRY2 ECM1 ABCA8 SVEP1 FBLN2 FBN1 LRP1 PRG4

1.44e-0720013181c10597edd532bf172ca09870a937d35e2585081
ToppCellTracheal-10x5prime-Stromal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PCSK5 ECM1 ABCA8 SVEP1 FBLN2 FBN1 LRP1 PRG4

1.44e-072001318920e6036c0a9c0089d0d898673daf9dd9d7279fc
ToppCellcellseq2-Mesenchymal-Fibroblastic-Fibroblastic_1|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SPRY2 ECM1 ABCA8 SVEP1 FBLN2 FBN1 LRP1 PRG4

1.44e-072001318440dda48b09c6a8581b7ca634b0d67f1ecacf65e
ToppCellLPS-antiTNF-Endothelial-Epi-like|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DPP6 ZNF658 NTN4 OVOL1 ZNF296 KCNJ14 ENDOU

2.38e-07144131775b16adfbe84f69376e6566d531ba7919d5c5192
ToppCelldroplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SELP VWF DENND4C FBN2 PIK3C2B CYYR1 OASL

6.49e-071671317774f3264318b002d0df5d06d41d645366038d0bf
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)|356C / Donor, Lineage, Cell class and subclass (all cells)

SELP CNTNAP3B VWF ENPP2 MATN2 PIK3C2B CYYR1

7.03e-071691317605cc2638271803cf1d972ab3fa8f13f89666376
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)-|356C / Donor, Lineage, Cell class and subclass (all cells)

SELP CNTNAP3B VWF ENPP2 MATN2 PIK3C2B CYYR1

7.03e-071691317337be3bf485b54afad86e256cb0c4c1d0c2a9a2a
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELP FAT4 VWF FBLN2 CCN2 RECK NPNT

7.31e-07170131750c6c571591aa4b218caefe5778c570c809f567e
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELP FAT4 VWF FBLN2 CCN2 RECK NPNT

7.31e-0717013178fe32dcf924d5f6665f7febbc9647d96b1e96f06
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELP FAT4 VWF FBLN2 CCN2 RECK NPNT

7.31e-0717013173232db50b1a40f861e981a1b9c9073b81af9f832
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TECTA ABCA8 SVEP1 FBLN2 FBN1 LRP1 TMEM255A

7.91e-071721317e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCellCOVID-19-Heart-EC_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

PCSK5 CNTNAP3B FAT4 VWF FBLN2 PIK3C2B CYYR1

1.03e-0617913172a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MATN2 ITGB1 ABCA8 SVEP1 LRP1 CCN2 CTSZ

1.07e-061801317ea7a1ccf0dd3bb5af5df87501f873e7339a824b3
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

SELP CNTNAP3B FAT4 VWF CNTNAP3 CYYR1 CCN2

1.07e-06180131727e8bbee388e64dd79d70b160b76d45b1f398006
ToppCelldroplet-Lung-1m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SELP PCSK5 VWF BMP1 LRIG1 PIK3C2B KCNJ14

1.11e-061811317136b0c60680068838d184d32aa99d7bea8718dbc
ToppCell3'-Child09-12-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SELP VWF ENPP2 CNTNAP3 NTN4 FBLN2 CYYR1

1.15e-0618213173cbeaf7904a76c32137a00abb20e302d3d3c8bb8
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SPRY2 MATN2 ABCA8 SVEP1 FBN1 LRP1 CCN2

1.15e-0618213173dfa9187e9d2bab1d199079d29209c4648220ada
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3B LYPD6B CNTNAP3 ECM1 EYS WIF1 PLCE1

1.15e-061821317a3c5c0eff527c8d3848acda14af8f9e99c69b0de
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAM20 TECTA ABCA8 FBLN2 FBN1 LRP4 PRG4

1.20e-06183131706a68fa2be36448064f4668be24a5b85ad85c6e8
ToppCellE15.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ENPP2 ISL1 ECM1 FBLN2 LRP2 NPNT PLCE1

1.20e-061831317274f274cf60daa30d6a4cd603a3af7823bfb8016
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3B LYPD6B CNTNAP3 NTN4 HMCN2 WIF1 PLCE1

1.24e-0618413177d41784eac0935e77d6bc701f20c693adf998730
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

MATN2 TENM2 FBLN2 FBN1 FBN2 LRIG1 NPNT

1.29e-0618513177dcdc009c5681ee05dd18968f7e85c3403fe34af
ToppCellEndothelial-A-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

SELP CNTNAP3B VWF CNTNAP3 CYYR1 CCN2 PEAR1

1.29e-061851317ae49c61f6ecf128fe2a958b8c75c83688da75f59
ToppCellCOVID-19-Heart-Fib_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

ABCA8 SVEP1 FBLN2 FBN1 HMCN2 LRP1 CCN2

1.29e-0618513178f95d8e591bf7379d13f5a0545b0cb49e2b1ab5d
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3B LYPD6B CNTNAP3 ECM1 FBN2 WIF1 PLCE1

1.29e-061851317f4ac62009c0ad3346e71b809e17727303c4df153
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

SELP CNTNAP3B FAT4 VWF CNTNAP3 PIK3C2B CYYR1

1.29e-061851317a7ae76058b2082020cadec49d63b9f4e24d21734
ToppCellControl-Endothelial-Endothelial-Artery|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 VWF LRP1B FBLN2 PIK3C2B CYYR1 CNTNAP4

1.34e-0618613172d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCellfacs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP2 ECM1 SVEP1 BMP1 FBLN2 FBN1 LRP1

1.34e-061861317a7ab70b049742dfe7ee30557031bfac6412edf52
ToppCellmetastatic_Lymph_Node-Endothelial_cells-Tumor_ECs|metastatic_Lymph_Node / Location, Cell class and cell subclass

SELP CNTNAP3B FAT4 VWF CNTNAP3 CYYR1 LRP4

1.38e-0618713172713f526f86911fbbf6c7a3e69230f2e6bde31c3
ToppCellLA-01._Fibroblast_I|World / Chamber and Cluster_Paper

PCSK5 ABCA8 SVEP1 FBLN2 FBN1 HMCN2 LRP1

1.38e-0618713174ea486991f66c29728d127171a07b81404ec0b78
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein|Children_(3_yrs) / Lineage, Cell type, age group and donor

SELP CNTNAP3B FAT4 VWF CNTNAP3 CYYR1 CCN2

1.38e-061871317e35716f8b482be3bf5ab79f087a9caf67a9d197a
ToppCellfacs-Heart-LA-24m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP2 MATN2 ECM1 SVEP1 FBLN2 FBN1 LRP1

1.38e-061871317f3ef3f5a761f8306edc39bf16e76e44aae6fa7f6
ToppCellCOVID-19-Heart-EC_2|Heart / Disease (COVID-19 only), tissue and cell type

PCSK5 CNTNAP3B FAT4 VWF ENPP2 PIK3C2B CYYR1

1.38e-06187131740ffc06a3e3251d9b12da390210d3e045af7537a
ToppCellfacs-Heart-LA-24m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP2 MATN2 ECM1 SVEP1 FBLN2 FBN1 LRP1

1.38e-0618713171669df899b1759c338ffce196fe009840123cfcd
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA8 SVEP1 FBLN2 FBN1 LRP1 CCN2 TMEM255A

1.43e-061881317c32d023a69b6da79687ff8fa7485e7499db57046
Drugpyrachlostrobin

NWD1 COL19A1 ECM1 ITGB1 SVEP1 DENND4C NTN4 FBLN2 FBN1 ADRB2 CNTNAP4 LRP2 LRP4 CCN2 CTSZ NOTCH1 PLCE1

2.76e-0681112717ctd:C513428
DrugTAAD

ACVR1B TGFB1 FBN1 FBN2

5.13e-06211274CID000133445
Diseaseautosomal recessive intellectual developmental disorder (implicated_via_orthology)

CNTNAP3B CNTNAP3 CNTNAP4

3.62e-0681203DOID:0060308 (implicated_via_orthology)
DiseaseCarcinoma, Granular Cell

FAT4 TGFB1 KMT2C CCN2 MUC2 PLCE1

8.22e-061161206C0205644
DiseaseAdenocarcinoma, Tubular

FAT4 TGFB1 KMT2C CCN2 MUC2 PLCE1

8.22e-061161206C0205645
DiseaseAdenocarcinoma, Oxyphilic

FAT4 TGFB1 KMT2C CCN2 MUC2 PLCE1

8.22e-061161206C0205642
DiseaseCarcinoma, Cribriform

FAT4 TGFB1 KMT2C CCN2 MUC2 PLCE1

8.22e-061161206C0205643
DiseaseAdenocarcinoma, Basal Cell

FAT4 TGFB1 KMT2C CCN2 MUC2 PLCE1

8.22e-061161206C0205641
DiseaseAdenocarcinoma

FAT4 TGFB1 KMT2C CCN2 MUC2 PLCE1

8.22e-061161206C0001418
DiseaseFEV/FEC ratio

PCSK5 SPRY2 FRAS1 ZNF165 KIAA0232 ACVR1B TG CRELD1 NTN4 FBN1 FCGBP ADRB2 LRP1 HHIPL1 PRG4 L3MBTL3 NPNT

1.00e-05122812017EFO_0004713
DiseaseLung diseases

PCSK5 SPRY2 TGFB1 ADRB2 CCN2

1.70e-05781205C0024115
Diseaseascending aortic diameter

ENPP2 FBN1 FBN2 LRIG1 FHL3 PLCE1

2.40e-051401206EFO_0021787
DiseaseTumoral calcinosis

ITGB1 TGFB1 C6 NOTCH1

2.58e-05421204C0263628
DiseaseCalcinosis

ITGB1 TGFB1 C6 NOTCH1

2.58e-05421204C0006663
DiseaseMicrocalcification

ITGB1 TGFB1 C6 NOTCH1

2.58e-05421204C0521174
Diseaseconnective tissue disease (implicated_via_orthology)

FBN1 FBN2

4.91e-0531202DOID:65 (implicated_via_orthology)
Diseasepulmonary fibrosis (biomarker_via_orthology)

VWF TGFB1 CCN2 NOTCH1

5.18e-05501204DOID:3770 (biomarker_via_orthology)
Diseasemyocardial infarction (is_implicated_in)

SELP ISL1 TGFB1 ADRB2 LRP1

5.39e-05991205DOID:5844 (is_implicated_in)
Diseasescoliosis (is_implicated_in)

FBN1 FBN2

9.79e-0541202DOID:0060249 (is_implicated_in)
DiseaseSushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 measurement

SVEP1 PEAR1

9.79e-0541202EFO_0803113
Diseasecholangiocarcinoma (is_marker_for)

TGFB1 ADRB2 MUC2 NOTCH1

1.37e-04641204DOID:4947 (is_marker_for)
DiseaseColorectal Carcinoma

SYNE1 ABCA8 TGFB1 KMT2C FBLN2 FBN2 ERGIC3 WIF1 LRP1 LRP2 FHL3

1.42e-0470212011C0009402
DiseaseColorectal Neoplasms

SYNE1 ABCA8 TGFB1 FBLN2 FBN2 WIF1 FHL3

1.44e-042771207C0009404
Diseasemigraine disorder, pulse pressure measurement

TGFB1 LRP1 PLCE1

1.59e-04261203EFO_0005763, MONDO_0005277
DiseaseGeleophysic dysplasia

TGFB1 FBN1

1.63e-0451202C3489726
DiseaseAcromicric Dysplasia

TGFB1 FBN1

1.63e-0451202C0265287
Diseaseresponse to platinum based chemotherapy, cytotoxicity measurement

FRAS1 EYS

1.63e-0451202EFO_0004647, EFO_0006952
DiseaseLeukemia, T-Cell

LMO1 NOTCH1

1.63e-0451202C0023492
Diseasepulse pressure measurement

ENPP2 SVEP1 DENND4C RNF215 TGFB1 FBN1 FBN2 LRIG1 MEGF8 PIK3C2A TRIM8 LRP1 HHIPL1 FHL3 NPNT PLCE1

1.68e-04139212016EFO_0005763
DiseaseHereditary Diffuse Gastric Cancer

FAT4 ECM1 KMT2C FCGBP ADRB2 WIF1 PLCE1

2.03e-042931207C1708349
DiseaseStomach Neoplasms

FAT4 ECM1 KMT2C FCGBP ADRB2 WIF1 PLCE1

2.20e-042971207C0038356
Diseasemigraine disorder, endometriosis

DPP6 LRP1B EYS PLCE1

2.28e-04731204EFO_0001065, MONDO_0005277
DiseaseMalignant neoplasm of stomach

FAT4 ECM1 KMT2C FCGBP ADRB2 WIF1 PLCE1

2.34e-043001207C0024623
Diseaseproteinuria (implicated_via_orthology)

TGFB1 C6 NPNT

2.46e-04301203DOID:576 (implicated_via_orthology)
Diseaseserum IgG glycosylation measurement

DPP6 STAB2 COL19A1 KIAA0232 LRP1B EYS OVOL1 KMT5B RECK

2.96e-045231209EFO_0005193
Diseasefactor VIII measurement, venous thromboembolism

STAB2 VWF LRP4

3.58e-04341203EFO_0004286, EFO_0004630
Diseasetriacylglycerol 58:6 measurement

LRP1B TENM2

4.52e-0481202EFO_0010440
Diseasemesangial proliferative glomerulonephritis (biomarker_via_orthology)

VWF FBN1

4.52e-0481202DOID:4783 (biomarker_via_orthology)
Diseasemyocardial infarction (biomarker_via_orthology)

SELP VWF TGFB1 ADRB2 CCN2

5.08e-041601205DOID:5844 (biomarker_via_orthology)
Diseaseulcerative colitis (biomarker_via_orthology)

ADRB2 MUC2

5.80e-0491202DOID:8577 (biomarker_via_orthology)
DiseaseSquamous cell carcinoma of esophagus

FAT4 KMT2C NOTCH1 PLCE1

6.23e-04951204C0279626
Diseaseaortic aneurysm

FBN1 LRP1

7.23e-04101202EFO_0001666
Diseasepneumonia (implicated_via_orthology)

ADRB2 MUC2

7.23e-04101202DOID:552 (implicated_via_orthology)
DiseaseAortic Valve Insufficiency

TGFB1 CCN2

8.81e-04111202C0003504
Diseasepneumonia

EXD3 HELZ2 MUC2

9.33e-04471203EFO_0003106
Diseasechronic musculoskeletal pain

ECM1 EXD3

1.05e-03121202EFO_0022195
Diseaseautoimmune thyroiditis (is_implicated_in)

TG LRP2

1.05e-03121202DOID:7188 (is_implicated_in)
Diseasecortical surface area measurement

SPRY2 LYPD6B ENPP2 TENM2 SVEP1 TG FOCAD NTN4 FBN1 FBN2 LRIG1 TRIM8 L3MBTL3 PLCE1

1.15e-03134512014EFO_0010736
Diseasefactor VIII measurement, coronary artery disease

STAB2 VWF TGFB1 HHIPL1

1.19e-031131204EFO_0001645, EFO_0004630
Diseaseliver cirrhosis (implicated_via_orthology)

FOCAD CCN2

1.24e-03131202DOID:5082 (implicated_via_orthology)
Diseasegallbladder cancer (is_implicated_in)

RICTOR LRP1B

1.24e-03131202DOID:3121 (is_implicated_in)
Diseaselate-onset Alzheimers disease

SELP ERO1A TECTA ABCA8 LRIG1 CYYR1

1.27e-032921206EFO_1001870
DiseaseFamilial thoracic aortic aneurysm and aortic dissection

FBN1 FBN2 NOTCH1

1.32e-03531203C4707243
Diseasevon Willebrand factor measurement, coronary artery disease

STAB2 VWF TGFB1 HHIPL1

1.40e-031181204EFO_0001645, EFO_0004629
Diseaseatrial fibrillation (is_implicated_in)

VWF ISL1

1.45e-03141202DOID:0060224 (is_implicated_in)
Diseaseforced expiratory volume

SPRY2 ENPP2 SYNE1 SVEP1 EYS ADRB2 SEC24C PIK3C2B L3MBTL3 NPNT

1.46e-0378912010EFO_0004314
DiseaseProteinuria

VWF LRP2

1.66e-03151202HP_0000093
Diseaseamino acid measurement

FAT4 VWF SYNE1 CNTNAP3 FBLN2 LRIG1 LRP2 MUC2 NOTCH1

1.84e-036781209EFO_0005134
Diseaselung small cell carcinoma (is_marker_for)

RICTOR ITGB1

1.90e-03161202DOID:5409 (is_marker_for)
DiseaseNeoplasm Metastasis

ENPP2 ITGB1 TGFB1 PIK3C2B RECK

1.97e-032171205C0027627
Diseasecystic fibrosis (is_marker_for)

TGFB1 ADRB2 MUC2

2.08e-03621203DOID:1485 (is_marker_for)
Diseasewellbeing measurement

FAT4 COL19A1 MUC19 ACVR1B OTOGL OASL LRP4 LRRC28 GNS

2.12e-036921209EFO_0007869
DiseaseSjogren's syndrome (implicated_via_orthology)

MUC19 TGFB1

2.14e-03171202DOID:12894 (implicated_via_orthology)
Diseasecervical artery dissection

LRP1 PLCE1

2.14e-03171202EFO_1000059
Diseasechronic obstructive pulmonary disease (is_implicated_in)

LRP1B TGFB1 ADRB2

2.18e-03631203DOID:3083 (is_implicated_in)
Diseaseischemia (biomarker_via_orthology)

MUC13 MUC2

2.40e-03181202DOID:326 (biomarker_via_orthology)
Diseaseneuroticism measurement, wellbeing measurement, depressive symptom measurement

COL19A1 ACVR1B

2.68e-03191202EFO_0007006, EFO_0007660, EFO_0007869
Diseasecarotid artery disease (is_marker_for)

VWF TGFB1

2.68e-03191202DOID:3407 (is_marker_for)
Diseasefactor VIII measurement, Ischemic stroke

STAB2 VWF

2.68e-03191202EFO_0004630, HP_0002140
Diseasecongenital heart disease (implicated_via_orthology)

SMYD4 KMT2C LRP2

2.83e-03691203DOID:1682 (implicated_via_orthology)
Diseaseglomerulonephritis (biomarker_via_orthology)

ITGB1 FBN1

2.97e-03201202DOID:2921 (biomarker_via_orthology)
Diseasetype 2 diabetes mellitus (biomarker_via_orthology)

ISL1 TGFB1 FBN1 CCN2

3.11e-031471204DOID:9352 (biomarker_via_orthology)
Diseasestomach cancer (is_implicated_in)

ACVR1B LRP1B KMT2C

3.19e-03721203DOID:10534 (is_implicated_in)
Diseasecoronary artery disease

DPP6 FAT4 VWDE ABCA8 SVEP1 TGFB1 BMP1 FBN2 LRP1 HHIPL1 FHL3 PLCE1

3.47e-03119412012EFO_0001645
Diseaseautism spectrum disorder (implicated_via_orthology)

CNTNAP3B CNTNAP3 KMT5B CNTNAP4

3.50e-031521204DOID:0060041 (implicated_via_orthology)
Diseaseaortic measurement

ENPP2 FBN1 LRIG1 LRP1 PLCE1

3.69e-032511205EFO_0020865
Diseasevenous thromboembolism, tissue plasminogen activator measurement

VWF LRP4

3.92e-03231202EFO_0004286, EFO_0004791

Protein segments in the cluster

PeptideGeneStartEntry
AINCYANETCCDFFT

ADRB2

181

P07550
LEGNCIDSQYYCNCD

CNTNAP3

726

Q9BZ76
DQECDKFNQCGTCNE

CTSZ

161

Q9UBR2
ECTSCLNSEGNFCIQ

ADH6

101

P28332
SCNVNAFCYEKTCNN

ADAM20

496

O43506
CTSCLQANYTCETDG

ACVR1B

36

P36896
ESSVNYCECNPCFNG

FAT4

3936

Q6V0I7
AACGRSIEDQKCYCE

ANKRD62

426

A6NC57
LEGNCIDSQYYCNCD

CNTNAP4

726

Q9C0A0
DFQGRCYNCISDCPN

CRYGA

11

P11844
QDCVNTFGSYECQCR

BMP1

716

P13497
CDKGLCTNSCQYQDL

CRISP2

196

P16562
CTNSCQYQDLLSNCD

CRISP2

201

P16562
SYCRGVQCACFSKDD

NWD1

1431

Q149M9
CQLGCRNLTYCTNFN

RECK

346

O95980
EIYSGKFCECDNFNC

ITGB1

546

P05556
ENCCQYGNVDECLSG

L3MBTL3

121

Q96JM7
DNVYHLDCFACQLCN

LMO1

106

P25800
DISGFETCIICCYEQ

VCPKMT

161

Q9H867
FCVNTEGSYECRDCA

CRELD1

261

Q96HD1
GTCQDRDNAYLCFCL

NOTCH1

616

P46531
FYNRQGTCSACDQSC

FRAS1

551

Q86XX4
CLSSFYQDSGLCKNC

FRAS1

991

Q86XX4
YQDSGLCKNCDSYCL

FRAS1

996

Q86XX4
EAKISEQLCAFCYCG

KMT2C

126

Q8NEZ4
EQLCAFCYCGEKSSL

KMT2C

131

Q8NEZ4
RSCKDQDECAVYGTC

LRP1B

151

Q9NZR2
QDECAVYGTCSQTCR

LRP1B

156

Q9NZR2
YLCDECSLNNGGCSN

LRP1B

1171

Q9NZR2
FECGNGECIDYQLTC

LRP1B

2516

Q9NZR2
CISASLKCNGEYDCA

LRP1B

3606

Q9NZR2
QCEDLNECLVFGTCS

LRP1B

3841

Q9NZR2
CEHECVNADGSYLCQ

MATN2

331

O00339
VKDCLFLSCQDYGDC

EYS

891

Q5T1H1
CSDCNTEVDCYSRGQ

LRIG1

931

Q96JA1
QCHDIDECSLGQYQC

NPNT

211

Q6UXI9
LRLCAQYSDFGCCDE

HHIPL1

36

Q96JK4
FVYADDCLAQCGKDC

CYYR1

21

Q96J86
ECLEGLDDCHYNQLC

HMCN2

4716

Q8NDA2
ECANGECINFSLTCD

LRP1

2531

Q07954
FFGENNEFCECYTCE

KMT5B

311

Q4FZB7
VENCAVIYCNDGFCE

KCNH2

36

Q12809
DNDSCGISLYKQCCD

FBLN2

506

P98095
ECEAQRCSQECANIY

FBLN2

946

P98095
YSEEVECKACDSNCG

PCSK5

1076

Q92824
FSADVNNYCCCLDAE

KIAA0232

851

Q92628
NNYCCCLDAEAELET

KIAA0232

856

Q92628
GNCVLKSQCDCYIND

MUC19

1126

Q7Z5P9
KFQSNDTCCEIGYCE

MUC19

8211

Q7Z5P9
EKASENFIYSCAGCC

PIK3C2A

1226

O00443
YDTCNCQNNEDCLCA

MUC2

616

Q02817
CQNNEDCLCAALSSY

MUC2

621

Q02817
GDCECFCSAVASYAQ

MUC2

1086

Q02817
DTYGVNCSARCSCEN

PEAR1

441

Q5VY43
QEFGNCCKDFESLCS

ENDOU

111

P21128
YGAEAEDIKCCNTCE

ERGIC3

146

Q9Y282
CVNCQNNSYGEKCES

MEGF8

2351

Q7Z7M0
YSDQKCDGTNNCGDC

LDLRAD1

136

Q5T700
TCQQGYFKCQSEGQC

LRP2

66

P98164
DCQYPTCEQLTCDNG

LRP2

141

P98164
TCEQLTCDNGACYNT

LRP2

146

P98164
TCDNGACYNTSQKCD

LRP2

151

P98164
GLQEHTDDNCLYCVC

RICTOR

1511

Q6R327
LECYSCVQKADDGCS

LYPD3

31

O95274
KLYVCEECGCTSESQ

OVOL1

211

O14753
TAFCYENELALSCCQ

KCNJ14

386

Q9UNX9
ASQCLKQDCCYDNRE

OASL

326

Q15646
EKAVENFIYSCAGCC

PIK3C2B

1171

O00750
SVFLCQCSCYVAEDQ

PSMG1

131

O95456
CYDNTFANTCAECQQ

FHL3

31

Q13643
TCQDSELLCNDCYCS

FHL3

81

Q13643
ELLCNDCYCSAFSSQ

FHL3

86

Q13643
CVCQSGTYGENCEKQ

C6

541

P13671
ASASCQYRCIECNQE

ARV1

26

Q9H2C2
YCSANLIAQETCCEI

COL19A1

231

Q14993
CQCDSGFLYNGQACV

FCGBP

1566

Q9Y6R7
NAECINTAGSYRCDC

FBN1

1821

P35555
NFICKNTEGSYQCSC

FBN1

2456

P35555
FQSSCKYQCTCLDGA

CCN2

116

P29279
CKNQCDDSEFRISYC

DEFB112

61

Q30KQ8
SCSQCRACGALVYDE

DENND4C

1491

Q5VZ89
YSQSQLVCSDCGCVV

BRF2

21

Q9HAW0
FCQVSGYLDDCTCDV

ERO1A

36

Q96HE7
SQCFPDCVCEDAYNN

GNS

436

P15586
QGECLETIGNYTCSC

SELP

171

P16109
CCYLSPGDEQVNCFN

ECM1

486

Q16610
CLDIDECSSFFGQVC

FBN2

1971

P35556
QCLSCDLVENCTYFS

DPP6

526

P42658
ENCADINFSCCYLCI

HELZ2

1996

Q9BYK8
FCKNANGSYTCEECD

CRELD2

246

Q6UXH1
CLQSESCNTQVKEYC

DYNAP

91

Q8N1N2
CCTQLADLYRNCETD

SEC24C

831

P53992
RCGIFQYETISCNNC

IZUMO4

131

Q1ZYL8
SEDCLARGDCCTNYQ

ENPP2

121

Q13822
LEGNCIDSQYYCNCD

CNTNAP3B

726

Q96NU0
NCCFDTSLEYNTGCI

FOCAD

1126

Q5VW36
DHNFQSDCGCIQYLC

OTOGL

2096

Q3ZCN5
SQYFFDCACPACQTE

SMYD4

591

Q8IYR2
CLCNTCADTLRYQAN

RNF157

296

Q96PX1
LQCVLADELCQCYNG

NARS1

156

O43776
EYNCLCLQASKGCQN

SYNE1

3046

Q8NF91
FCCDLYNCGNRVEIT

TMEM255A

186

Q5JRV8
VAYCCSTQCLQTFDL

LRRC28

351

Q86X40
DCQHNTEGQYCQRCK

NTN4

361

Q9HB63
CDTLNDKYFCFEGSC

PLCE1

256

Q9P212
GAETCAVCLDYFCNK

RNF215

321

Q9Y6U7
DCKNDVNCNCYSGDD

TENM2

1521

Q9NT68
CIDNCPDCGNRSFYD

PRAMEF27

456

A3QJZ7
DVPLSYCNSECNCDE

SLCO1B7

406

G3V0H7
ACLKCAECNQYLDES

ISL1

41

P61371
AECNQYLDESCTCFV

ISL1

46

P61371
ATCVDELNSYSCKCQ

SVEP1

1396

Q4LDE5
EGYSRDATCNCDYNC

PRG4

36

Q92954
CDKQCLCSAQNVIDY

SPRY2

201

O43597
VCCNEKNYSFSLACN

ABCA8

961

O94911
ECDYINARSCCSKLN

CNIH4

31

Q9P003
DCQIFCYCSGTDNRV

TECTA

1056

O75443
CGNRSFYDLEADQCC

PRAMEF6

461

Q5VXH4
DGACQVCGLYKNDSC

VWDE

1036

Q8N2E2
GLLYECCVEFCQSKA

WDR47

201

O94967
SKEACQQAGCCYDNT

ZP1

251

P60852
YKEENNTGECCGRCL

VWF

2631

P04275
CDYYGCNQTADDCLN

MUC13

326

Q9H3R2
DTNYCFSSTEKNCCV

TGFB1

281

P01137
LCNLLNSEDYNTCEG

TNPO2

131

O14787
QKLFTRDGCYVCSDC

ZNF587

231

Q96SQ5
CGNRSFYDLEADQCC

PRAMEF5

461

Q5TYX0
QKLFTRDGCYVCSDC

ZNF417

231

Q8TAU3
CLDQYSATGECKCNT

STAB2

1976

Q8WWQ8
CKENNTCECNLDYEG

STAB2

2061

Q8WWQ8
FYGVNCDKANCSTTC

WIF1

236

Q9Y5W5
SYTCNQECDNCLNAT

TAS1R2

356

Q8TE23
ECNECGKAFCQNSNL

ZNF658

441

Q5TYW1
GQQKRFCCQSCINEY

ZMYM5

401

Q9UJ78
YICEECGKACNQFTN

ZNF681

226

Q96N22
CYECNECGKSFAESS

ZNF165

371

P49910
YECSLCERAFCGKSQ

ZNF26

426

P17031
CTESCNSKYQCETGE

SRY

36

Q05066
PYECSECGKTFCQNS

ZNF12

576

P17014
LASSYECRCGNNFCA

ZFAND4

676

Q86XD8
LVCSVDNCYCSSVAN

TRIM8

466

Q9BZR9
CSQSYCCQTELEGED

UBR2

1641

Q8IWV8
GYCTCELDCINTASK

UBR4

2666

Q5T4S7
VQCFNSECYCVDAEG

TG

696

P01266
YQCEECGKVFRTCSS

ZNF195

466

O14628
YQCGECGKVFSENSC

ZNF836

526

Q6ZNA1
LNEQIFYICEECGKC

ZNF662

186

Q6ZS27
FYICEECGKCFDQNE

ZNF662

191

Q6ZS27
CEFCNYACAQSSKLN

ZNF296

416

Q8WUU4
ECNECGKAFCQNSNL

ZNF658B

201

Q4V348
PYKCNECGNNFSCVS

ZNF527

581

Q8NB42
KCFTCENAGDNYNCN

LYPD6B

61

Q8NI32
HTCQDVNECAEEGYC

LRP4

391

O75096
ADIFSRCQACNCDQY

EXD3

721

Q8N9H8