Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Dopey_N	DOP1A DOP1B	4.23e-05	2	122	2	PF04118
Domain	Dopey_N	DOP1A DOP1B	4.23e-05	2	122	2	IPR007249
Domain	Fumarylacetoacetase_C-rel	FAHD2B FAHD2A	2.52e-04	4	122	2	IPR011234
Domain	FAA_hydrolase	FAHD2B FAHD2A	2.52e-04	4	122	2	PF01557
Domain	-	FAHD2B FAHD2A	2.52e-04	4	122	2	3.90.850.10
Domain	Histone_deAcase_II_euk	HDAC4 HDAC7	2.52e-04	4	122	2	IPR017320
Domain	PAN_AP	MST1 MST1L	4.18e-04	5	122	2	SM00473
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	STK36 MORN1 TMEM158 OBSCN AKNA SLC10A3 ZFPM1 GBA2 HDAC7 RYR1 NCOR2 ZFP36L2 FURIN TMEM132A HELZ2 AP1G2 NUP188 ABCC10 ARAP1	2.47e-08	1105	128	19	35748872
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	ELP5 AKNA PDZD7 ZFPM1 CDC42EP3 STPG3 CEP295 SLC39A7	2.58e-06	233	128	8	37704626
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	TTC21A OBSCN IGDCC3 PIDD1 DNAH14 RYR1 TMEM260 MST1 GSE1 CHRD CEP295 NUP188 DOP1B	3.50e-06	736	128	13	29676528
Pubmed	Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo.	HDAC4 HDAC7 NCOR2	4.02e-06	9	128	3	11466315
Pubmed	Structural basis of the specific interaction of SMRT corepressor with histone deacetylase 4.	HDAC4 NCOR2	1.34e-05	2	128	2	30321390
Pubmed	Differential expression of murine CGI-105 gene in 3T3-L1 cells by adrenocorticotropic hormones.	FAHD2B FAHD2A	1.34e-05	2	128	2	15774318
Pubmed	Mst1 regulates post-infarction cardiac injury through the JNK-Drp1-mitochondrial fission pathway.	MST1 MST1L	1.34e-05	2	128	2	29760744
Pubmed	G-CSF mediates lung injury in mice with adenine-induced acute kidney injury.	CSF3 SIGLEC1	1.34e-05	2	128	2	30056257
Pubmed	Cell type-specific spatial and functional coupling between mammalian brain Kv2.1 K+ channels and ryanodine receptors.	RYR1 KCNB1	1.34e-05	2	128	2	24962901
Pubmed	Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3.	MST1 MST1L	1.34e-05	2	128	2	8393443
Pubmed	MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis.	MST1 MST1L	1.34e-05	2	128	2	27609031
Pubmed	Cleavage of Kv2.1 by BACE1 decreases potassium current and reduces neuronal apoptosis.	BACE1 KCNB1	1.34e-05	2	128	2	35231557
Pubmed	Hepatocyte growth factor-like protein is required for prostate tumor growth in the TRAMP mouse model.	MST1 MST1L	1.34e-05	2	128	2	24980820
Pubmed	Mst1 deletion reduces hyperglycemia-mediated vascular dysfunction via attenuating mitochondrial fission and modulating the JNK signaling pathway.	MST1 MST1L	1.34e-05	2	128	2	31206688
Pubmed	Structure of the human D1F15S1A locus: a chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein.	MST1 MST1L	1.34e-05	2	128	2	10728827
Pubmed	Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: an animal model to study the neurobiology of alcoholism.	MST1 MST1L	1.34e-05	2	128	2	16961763
Pubmed	Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties.	BACE1 FURIN	1.34e-05	2	128	2	10887202
Pubmed	Mutagenesis Study Reveals the Rim of Catalytic Entry Site of HDAC4 and -5 as the Major Binding Surface of SMRT Corepressor.	HDAC4 NCOR2	1.34e-05	2	128	2	26161557
Pubmed	Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice.	MST1 MST1L	1.34e-05	2	128	2	39253972
Pubmed	Cerebral ischemia-reperfusion is modulated by macrophage-stimulating 1 through the MAPK-ERK signaling pathway.	MST1 MST1L	1.34e-05	2	128	2	32017081
Pubmed	Mst1 inhibition attenuates non-alcoholic fatty liver disease via reversing Parkin-related mitophagy.	MST1 MST1L	1.34e-05	2	128	2	30708325
Pubmed	Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.	MST1 MST1L	1.34e-05	2	128	2	24409221
Pubmed	Melatonin alleviates postinfarction cardiac remodeling and dysfunction by inhibiting Mst1.	MST1 MST1L	1.34e-05	2	128	2	27696525
Pubmed	Hepatocyte-specific expression of the mouse hepatocyte growth factor-like protein.	MST1 MST1L	1.34e-05	2	128	2	8340069
Pubmed	Biological effects of targeted inactivation of hepatocyte growth factor-like protein in mice.	MST1 MST1L	1.34e-05	2	128	2	9486989
Pubmed	Treatment with XMU-MP-1 erases hyperglycaemic memory in hearts of diabetic mice.	MST1 MST1L	1.34e-05	2	128	2	33887258
Pubmed	Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a member of a novel family of leucine zipper-like proteins conserved from yeast to humans.	DOP1A DOP1B	1.34e-05	2	128	2	10931277
Pubmed	HGFL supports mammary tumorigenesis by enhancing tumor cell intrinsic survival and influencing macrophage and T-cell responses.	MST1 MST1L	1.34e-05	2	128	2	25938541
Pubmed	Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation.	HDAC4 HDAC7	1.34e-05	2	128	2	38657041
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	KPNA4 STK36 ATN1 HDAC4 INPP5D SH2B1 NCOR2 ZNF469 ARAP1	3.24e-05	430	128	9	35044719
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	KPNA4 ZNF787 POLR1A RTCB IPO4 CREB3L4 CEP164 WDR43 FAM83B FARSA TFPT ZFP36L2 IMP4 HELZ2 CPSF2 HEATR5B TBX2	3.65e-05	1497	128	17	31527615
Pubmed	Cellular, biochemical and molecular changes in muscles from patients with X-linked myotubular myopathy due to MTM1 mutations.	HDAC4 RYR1	4.02e-05	3	128	2	28007904
Pubmed	The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse.	MST1 MST1L	4.02e-05	3	128	2	10225971
Pubmed	Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes.	MST1 MST1L	4.02e-05	3	128	2	38430683
Pubmed	Macrophage stimulating protein is a target-derived neurotrophic factor for developing sensory and sympathetic neurons.	MST1 MST1L	4.02e-05	3	128	2	12538524
Pubmed	Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes.	MST1 MST1L	4.02e-05	3	128	2	19339990
Pubmed	TRAF2 functions as an activator switch in the reactive oxygen species-induced stimulation of MST1.	MST1 MST1L	4.02e-05	3	128	2	26698664
Pubmed	Melatonin activates Parkin translocation and rescues the impaired mitophagy activity of diabetic cardiomyopathy through Mst1 inhibition.	MST1 MST1L	4.02e-05	3	128	2	30063115
Pubmed	Mst1-mediated phosphorylation of Bcl-xL is required for myocardial reperfusion injury.	MST1 MST1L	4.02e-05	3	128	2	27218122
Pubmed	Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction.	MST1 MST1L	4.02e-05	3	128	2	17395874
Pubmed	Genetic deletion of Mst1 alters T cell function and protects against autoimmunity.	MST1 MST1L	4.02e-05	3	128	2	24852423
Pubmed	Identification of a signal-responsive nuclear export sequence in class II histone deacetylases.	HDAC4 HDAC7	4.02e-05	3	128	2	11509672
Pubmed	Co-repressor SMRT and class II histone deacetylases promote Bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression.	HDAC4 NCOR2	4.02e-05	3	128	2	17383980
Pubmed	Mst1 participates in the atherosclerosis progression through macrophage autophagy inhibition and macrophage apoptosis enhancement.	MST1 MST1L	4.02e-05	3	128	2	27496379
Pubmed	Macrophage-stimulating protein cooperates with erythropoietin to induce colony formation and MAP kinase activation in primary erythroid progenitor cells.	MST1 MST1L	4.02e-05	3	128	2	12804176
Pubmed	Receptor tyrosine kinase Ron is expressed in mouse reproductive tissues during embryo implantation and is important in trophoblast cell function.	MST1 MST1L	4.02e-05	3	128	2	12606483
Pubmed	Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice.	MST1 MST1L	4.02e-05	3	128	2	36623453
Pubmed	A universal metabolite repair enzyme removes a strong inhibitor of the TCA cycle.	FAHD2B FAHD2A	4.02e-05	3	128	2	38287013
Pubmed	Hippo Kinase MST1-Mediated Cell Metabolism Reprograms the Homeostasis and Differentiation of Granulocyte Progenitor Cells.	MST1 MST1L	4.02e-05	3	128	2	37184367
Pubmed	CircRbms1 fosters MST1 mRNA and protein levels to motivate myocardial ischaemia-reperfusion injury via autophagic status.	MST1 MST1L	4.02e-05	3	128	2	38288506
Pubmed	The proto-oncogene RON is involved in development of epithelial, bone and neuro-endocrine tissues.	MST1 MST1L	4.02e-05	3	128	2	8545120
Pubmed	Hepatocyte growth factor-like protein is a positive regulator of early mammary gland ductal morphogenesis.	MST1 MST1L	4.02e-05	3	128	2	25049204
Pubmed	Characterization of the mouse cDNA and gene coding for a hepatocyte growth factor-like protein: expression during development.	MST1 MST1L	4.02e-05	3	128	2	1832957
Pubmed	Activation of pro-survival CaMK4β/CREB and pro-death MST1 signaling at early and late times during a mouse model of prion disease.	MST1 MST1L	4.02e-05	3	128	2	25183307
Pubmed	MST1 mediates neuronal loss and cognitive deficits: A novel therapeutic target for Alzheimer's disease.	MST1 MST1L	4.02e-05	3	128	2	35525373
Pubmed	MST1 coordinately regulates autophagy and apoptosis in diabetic cardiomyopathy in mice.	MST1 MST1L	4.02e-05	3	128	2	27510910
Pubmed	Novel structural insights into class I and II histone deacetylases.	HDAC4 HDAC7	4.02e-05	3	128	2	19355988
Pubmed	Combination of melatonin and irisin ameliorates lipopolysaccharide-induced cardiac dysfunction through suppressing the Mst1-JNK pathways.	MST1 MST1L	4.02e-05	3	128	2	31976559
Pubmed	Over-expressed MST1 impaired spatial memory via disturbing neural oscillation patterns in mice.	MST1 MST1L	4.02e-05	3	128	2	32468668
Pubmed	Nicorandil alleviates myocardial injury and post-infarction cardiac remodeling by inhibiting Mst1.	MST1 MST1L	4.02e-05	3	128	2	29127009
Pubmed	Mst1 Kinase Regulates the Actin-Bundling Protein L-Plastin To Promote T Cell Migration.	MST1 MST1L	4.02e-05	3	128	2	27465533
Pubmed	Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease.	INPP5D CSF3	4.02e-05	3	128	2	29708507
Pubmed	Suramin protects hepatocytes from LPS-induced apoptosis by regulating mitochondrial stress and inactivating the JNK-Mst1 signaling pathway.	MST1 MST1L	4.02e-05	3	128	2	30771091
Pubmed	Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus.	DOP1A DOP1B	4.02e-05	3	128	2	16301316
Pubmed	MST1 mediates the N-methyl-D-aspartate-induced excitotoxicity in mouse cortical neurons.	MST1 MST1L	4.02e-05	3	128	2	34967918
Pubmed	Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity.	MST1 MST1L	4.02e-05	3	128	2	38898027
Pubmed	WASP and Mst1 coregulate B-cell development and B-cell receptor signaling.	MST1 MST1L	4.02e-05	3	128	2	32045478
Pubmed	Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2.	MST1 MST1L	4.02e-05	3	128	2	27940445
Pubmed	Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.	FOXD2 ADAMTSL1 AOAH MACROH2A1 PKHD1L1 HDAC7 TFPT KCNB1 CPSF2 PLOD2 MYO16 TMEM82	4.96e-05	814	128	12	23251661
Pubmed	Inhibition of TLR4-induced IκB kinase activity by the RON receptor tyrosine kinase and its ligand, macrophage-stimulating protein.	MST1 MST1L	8.02e-05	4	128	2	21078906
Pubmed	MST1 controls murine neutrophil homeostasis via the G-CSFR/STAT3 axis.	MST1 MST1L	8.02e-05	4	128	2	36618429
Pubmed	HDAC4 regulates satellite cell proliferation and differentiation by targeting P21 and Sharp1 genes.	BHLHE41 HDAC4	8.02e-05	4	128	2	29472596
Pubmed	Hyperglycemia-Induced Overexpression of PH Domain Leucine-Rich Repeat Protein Phosphatase 1 (PHLPP1) Compromises the Cardioprotective Effect of Ischemic Postconditioning Via Modulation of the Akt/Mst1 Pathway Signaling.	MST1 MST1L	8.02e-05	4	128	2	35715527
Pubmed	Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking.	MST1 MST1L	8.02e-05	4	128	2	25074980
Pubmed	OSM mitigates post-infarction cardiac remodeling and dysfunction by up-regulating autophagy through Mst1 suppression.	MST1 MST1L	8.02e-05	4	128	2	27825852
Pubmed	A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway.	KPNA4 IPO4	8.02e-05	4	128	2	12610148
Pubmed	Developmentally regulated N-terminal variants of the nuclear receptor hepatocyte nuclear factor 4alpha mediate multiple interactions through coactivator and corepressor-histone deacetylase complexes.	HDAC4 NCOR2	8.02e-05	4	128	2	12205093
Pubmed	MST1 deficiency promotes B cell responses by CD4+ T cell-derived IL-4, resulting in hypergammaglobulinemia.	MST1 MST1L	8.02e-05	4	128	2	28527887
Pubmed	Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration.	MST1 MST1L	8.02e-05	4	128	2	25133611
Pubmed	LncRNA SNHG17 knockdown promotes Parkin-dependent mitophagy and reduces apoptosis of podocytes through Mst1.	MST1 MST1L	8.02e-05	4	128	2	32627655
Pubmed	Macrophage MST1/2 Disruption Impairs Post-Infarction Cardiac Repair via LTB4.	MST1 MST1L	8.02e-05	4	128	2	34515499
Pubmed	The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3.	HDAC4 NCOR2	8.02e-05	4	128	2	11509652
Pubmed	The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes.	MST1 MST1L	8.02e-05	4	128	2	22412158
Pubmed	Functional role of Mst1/Mst2 in embryonic stem cell differentiation.	MST1 MST1L	8.02e-05	4	128	2	24224013
Pubmed	Mst1 regulates hepatic lipid metabolism by inhibiting Sirt1 ubiquitination in mice.	MST1 MST1L	8.02e-05	4	128	2	26903296
Pubmed	Glyceraldehyde-3-phosphate dehydrogenase interacts with proapoptotic kinase mst1 to promote cardiomyocyte apoptosis.	MST1 MST1L	8.02e-05	4	128	2	23527007
Pubmed	A cell-intrinsic role for Mst1 in regulating thymocyte egress.	MST1 MST1L	8.02e-05	4	128	2	19692642
Pubmed	Melatonin protects against diabetic cardiomyopathy through Mst1/Sirt3 signaling.	MST1 MST1L	8.02e-05	4	128	2	28480597
Pubmed	Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion.	MST1 MST1L	8.02e-05	4	128	2	16892067
Pubmed	Hippo signaling pathway reveals a spatio-temporal correlation with the size of primordial follicle pool in mice.	MST1 MST1L	8.02e-05	4	128	2	25659841
Pubmed	Mammalian Sterile 20-like Kinase 1 (Mst1) Enhances the Stability of Forkhead Box P3 (Foxp3) and the Function of Regulatory T Cells by Modulating Foxp3 Acetylation.	MST1 MST1L	8.02e-05	4	128	2	26538561
Pubmed	MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS.	MST1 MST1L	8.02e-05	4	128	2	23818595
Pubmed	RON (MST1R) and HGFL (MST1) Co-Overexpression Supports Breast Tumorigenesis through Autocrine and Paracrine Cellular Crosstalk.	MST1 MST1L	8.02e-05	4	128	2	35626096
Pubmed	Mammalian sterile 20-like kinase 1 suppresses lymphoma development by promoting faithful chromosome segregation.	MST1 MST1L	8.02e-05	4	128	2	22926556
Pubmed	Class IIa histone deacetylases: conducting development and differentiation.	HDAC4 HDAC7	8.02e-05	4	128	2	19412888
Pubmed	Treatment with Mammalian Ste-20-like Kinase 1/2 (MST1/2) Inhibitor XMU-MP-1 Improves Glucose Tolerance in Streptozotocin-Induced Diabetes Mice.	MST1 MST1L	8.02e-05	4	128	2	32987643
Pubmed	The Mst1 Kinase Is Required for Follicular B Cell Homing and B-1 B Cell Development.	MST1 MST1L	8.02e-05	4	128	2	30386341
Pubmed	A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870.	MST1 MST1L	8.02e-05	4	128	2	27919044
Pubmed	Mst1/2 Kinases Modulate Glucose Uptake for Osteoblast Differentiation and Bone Formation.	MST1 MST1L	8.02e-05	4	128	2	29474739
Pubmed	mTORC2 regulates cardiac response to stress by inhibiting MST1.	MST1 MST1L	8.02e-05	4	128	2	25843706
GeneFamily	Histone deacetylases, class IIA	HDAC4 HDAC7	9.08e-05	4	71	2	992
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	ROBO4 ADAMTSL1 OBSCN IGDCC3 SIGLEC1	4.27e-04	161	71	5	593
GeneFamily	Dyneins, axonemal	DNAH14 DNAH17	1.99e-03	17	71	2	536
GeneFamily	Cadherin related	PCDH15 DCHS1	1.99e-03	17	71	2	24
GeneFamily	Armadillo repeat containing\|Importins	KPNA4 IPO4	2.23e-03	18	71	2	596
Coexpression	GSE2826_WT_VS_BTK_KO_BCELL_UP	RTCB INPP5D MACROH2A1 NPEPL1 TFPT SRPK3 CPSF2 MUTYH	5.81e-06	200	126	8	M4898
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM STK36 OBSCN PKHD1L1 PCDH15 UNC79 MYO16	1.12e-06	184	129	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM STK36 OBSCN PKHD1L1 PCDH15 UNC79 MYO16	1.12e-06	184	129	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM STK36 OBSCN PKHD1L1 PCDH15 UNC79 MYO16	1.12e-06	184	129	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Cadm2_(Cadm2_state)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	CAND2 RTBDN TRIM14 VSIG10L AP1G2	4.10e-06	82	129	5	01a4d47d9e0dee68a5277ed1534338cec80f75d1
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Cadm2_(Cadm2_state)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	CAND2 RTBDN TRIM14 VSIG10L AP1G2	4.10e-06	82	129	5	c1489097c291f413f3cfa5e26f8182ec872328fd
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GGT6 POU3F3 CHADL CREB3L4 AP1G2 MYO16	6.09e-06	155	129	6	8b524c65fa5c901f70c7caae4ec7fd2859eaf227
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_low-phase\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GGT6 POU3F3 CHADL CREB3L4 AP1G2 MYO16	6.09e-06	155	129	6	7fe8b8c0c8a9e3190cfd52d3934509e6780e1717
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	ADAMTSL1 KCNH7 GABBR2 RYR1 PCDH15 MYO16	7.04e-06	159	129	6	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	facs-Trachea-nan-18m-Mesenchymal-chondrocyte\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	POU3F3 PDZD7 CHADL RTBDN CDC42EP3 STPG3	9.32e-06	167	129	6	7b1fd19946cee67dae68f0f0d98420abcd532482
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-Pleural_Mac\|Myeloid_cells / Location, Cell class and cell subclass	OBSCN PIDD1 PDZD7 DCHS1 WDR73 HEATR5B	9.65e-06	168	129	6	8697b40b2ec2cce68ef3beb4792eb3eff29be053
ToppCell	3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Differentiating_glia\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KLK6 PCDHAC2 POU3F3 COL25A1 RNF157 UNC79	1.30e-05	177	129	6	0417460bdb012bc43d7254377fa53d79cdab3f34
ToppCell	Control-Lymphoid-ILC_A\|World / Disease state, Lineage and Cell class	INPP5D AOAH AKNA ZFPM1 ZFP36L2 TOX2	1.72e-05	186	129	6	7bc939bf4e71bb4c6409b862c1f6c547d775e089
ToppCell	Control-Lymphoid-ILC_A\|Control / Disease state, Lineage and Cell class	INPP5D AOAH AKNA ZFPM1 ZFP36L2 TOX2	2.00e-05	191	129	6	1ca73582dc3d28322b5ee841010067589d848acc
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	INPP5D AOAH AKNA TRIM14 RYR1 SIGLEC1	2.24e-05	195	129	6	09df40ff9b493170861b3f6e57a942a834655b5c
Drug	Aconitine [302-27-2]; Down 200; 6.2uM; PC3; HT_HG-U133A	KLK6 CAND2 GABBR2 NPEPL1 TRIM14 RHBDD3 MFSD10 DOP1B TBX2	1.67e-06	197	127	9	7149_DN
Drug	Clozapine [5786-21-0]; Up 200; 12.2uM; MCF7; HT_HG-U133A	ATN1 HDAC7 SLC1A4 NCOR2 KCNB1 ZFP36L2 ARAP1 DOP1B	1.41e-05	195	127	8	5265_UP
Drug	Nalidixic acid sodium salt hydrate; Down 200; 14.6uM; HL60; HT_HG-U133A	TMEM158 PIDD1 PROSER1 PDZD7 NPEPL1 TRIM14 GSE1 RHBDD3	1.41e-05	195	127	8	2336_DN
Drug	Kynurenine, 3-hydroxy (R,S) [2147-61-7]; Up 200; 17.8uM; MCF7; HT_HG-U133A	ATN1 HDAC7 SLC1A4 RYR1 RGS14 NCOR2 ZFP36L2 ARAP1	1.52e-05	197	127	8	5276_UP
Drug	Alfaxalone [23930-19-0]; Up 200; 12uM; HL60; HT_HG-U133A	KLK6 GABBR2 NPEPL1 PIGZ CEP164 RGS14 NCOR2 ZFP36L2	1.57e-05	198	127	8	3135_UP
Drug	Canrenoic acid potassium salt [2181-04-6]; Up 200; 10uM; MCF7; HT_HG-U133A	ATN1 MORN1 PIDD1 CDC42EP3 SLC1A4 ZFP36L2 SIGLEC1 ARAP1	1.63e-05	199	127	8	6783_UP
Disease	Usher Syndrome, Type II	PDZD7 PCDH15	1.65e-04	5	121	2	C1568249
Disease	ceramide measurement	POLR1A CREB3L4 GBA2 DEGS1 PCDH15 PRDM15	4.29e-04	235	121	6	EFO_0010222
Disease	basophil percentage of leukocytes	ZFPM1 RYR1 TCF23 ZNF469 GSE1 CSF3	5.12e-04	243	121	6	EFO_0007992
Disease	anemia (phenotype), response to ribavirin	DNAH17 ZNF804B	5.89e-04	9	121	2	EFO_0004272, GO_1901559
Disease	putamen volume change measurement	DCHS1 MYO16	1.26e-03	13	121	2	EFO_0021495
Disease	Down syndrome (implicated_via_orthology)	DOP1A DOP1B	1.69e-03	15	121	2	DOID:14250 (implicated_via_orthology)
Disease	Generalized hypotonia	ATN1 POU3F3	1.69e-03	15	121	2	C1858120
Disease	proprotein convertase subtilisin/kexin type 7 measurement	BACE1 CEP164	2.18e-03	17	121	2	EFO_0008270
Disease	urolithiasis	ZFPM1 RGS14 ZFP36L2	2.23e-03	63	121	3	MONDO_0024647
Disease	cytomegalovirus virus reactivation, response to allogeneic hematopoietic stem cell transplant	CDC42EP3 GSE1	2.72e-03	19	121	2	EFO_0007044, EFO_0020106
Disease	serum alanine aminotransferase measurement, response to combination chemotherapy	HDAC4 KCNB1 CEP295	3.14e-03	71	121	3	EFO_0004735, EFO_0007965
Disease	stomach cancer (is_implicated_in)	TMEM260 GSE1 MUTYH	3.26e-03	72	121	3	DOID:10534 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
VLPAHGTQHGIRLPL	BACE1	16	P56817
DAVLLSHPDPLHLGA	CPSF2	56	Q9P2I0
ATLLPHEVAPLGAPH	BHLHE41	431	Q9C0J9
PHLLPGVRLGAHILD	GRM2	76	Q14416
PSFLPVAELHGLRGH	GSE1	406	Q14687
ASGGVLPNIHPELLA	MACROH2A1	101	O75367
VHPLIDPLASGSHLT	ATN1	1076	P54259
PHLDPSPGGALVHLL	AP1G2	641	O75843
LHPALPGGVHRKALE	DOP1A	71	Q5JWR5
SHGGPALSLPLPLHA	APBB1	16	O00213
ISPPLGDFRHTIHIG	CDC42EP3	31	Q9UKI2
VPRLLHGLADGAHGL	TFAP2E	136	Q6VUC0
FRLHGGPSSHLVPEL	C17orf113	321	A0A1B0GUU1
EHRGTPVGLIVSHLP	IMP4	141	Q96G21
HIAGHLPASRLPVAA	FBXW10B	711	O95170
HLPNGSHVILYGLPD	AOAH	406	P28039
PLPRGDLELHLGALH	MORN1	321	Q5T089
LPGLLESHGRAHDPL	MFSD10	46	Q14728
PHGHSRGPLALALVA	ABCC10	126	Q5T3U5
GHPLPLGLHDTARPV	NCOR2	1081	Q9Y618
VKLGGEAAHLPHLRP	NCOR2	2091	Q9Y618
LHPHSGELLTAAPLI	DCHS1	1266	Q96JQ0
ILTGLPHAPGLDALL	OR10G4	11	Q8NGN3
QAPLVTGLGALPLHA	HDAC4	426	P56524
LLLLPAPSEGLGHSA	IGDCC3	26	Q8IVU1
ILHLLLGSPHPAATA	LPCAT4	436	Q643R3
LGSPHPAATALHAEL	LPCAT4	441	Q643R3
HPEPGHVLRTSLDGA	DNAAF2	71	Q9NVR5
GTELQHLLHAVVPGP	MST1L	36	Q2TV78
LLHGASPPLLHRAPE	MYO16	1451	Q9Y6X6
IVGLHRHVSDPGLPG	KCNH7	1181	Q9NS40
LHPALPSGVHLKALE	DOP1B	71	Q9Y3R5
LPAPLDHINLHVRGG	MGAM	2596	O43451
KLGSPHHLHEGSLLL	ADAMTSL1	1326	Q8N6G6
GGLSDDHVLILPIGH	CWF19L1	356	Q69YN2
LGGTHIDLLFHPPRA	FAM83B	116	Q5T0W9
HSGLAGLAPLHIQLV	SLC10A3	136	P09131
LHPPALAVLSHTPDG	NPEPL1	236	Q8NDH3
DGGLPADHLPAHQPL	PDZD7	966	Q9H5P4
GAPSIHLLPDTLDHL	COL25A1	71	Q9BXS0
PAGGLLSVLLTAEPH	ZFPM1	181	Q8IX07
EPLDPGGHLHLLQDL	GDPGP1	236	Q6ZNW5
GGHLHLLQDLPAPGF	GDPGP1	241	Q6ZNW5
QFRAPHLVGPHLGLE	FAHD2A	31	Q96GK7
PGRLTHLHEGLPVKN	PLOD2	711	O00469
LLRGPHPGTSDLHIS	PROSER1	581	Q86XN7
LGGTAPHVEELLSHL	KICS2	111	Q96MD2
ALRLPASGTHLAPGH	OBSCN	6946	Q5VST9
ALHHLVLTAVDGGIP	PCDHAC2	221	Q9Y5I4
NGHPLPAFAGLHIEI	PCDH15	371	Q96QU1
LLGGVHQCPLGIPHA	HEATR5B	511	Q9P2D3
HISPDVRVLPGGGAH	KCNB1	836	Q14721
VVAQPGPDHLDHLLL	LINC01555	11	Q8NAE3
LLPIPEHLGSLDGTL	DNAH17	161	Q9UFH2
GETVRGLLLHHPTLP	GBA2	316	Q9HCG7
QFRAPHLVGPHLGLE	FAHD2B	31	Q6P2I3
AGLLPSHLPEVVAGL	FURIN	706	P09958
GLGLPAALPTLHLLH	GGT6	176	Q6P531
SLLGLGLHPISGHFI	DEGS1	216	O15121
LAETLPEGPSHHLLS	AKNA	231	Q7Z591
LLLHGLGEGSALLHP	APCDD1	16	Q8J025
VLPIHPSLALAGVGG	DNAH14	141	Q0VDD8
HPEELVLLGHSLGIP	CSF3	76	P09919
LPILHHAYLPSIGGV	GABBR2	896	O75899
VSVLGLLHEELHGPG	ELP5	161	Q8TE02
LLHEELHGPGPVGAL	ELP5	166	Q8TE02
LGSPHTPLFLPHGLE	HDAC7	281	Q8WUI4
GTELQHLLHAVVPGP	MST1	31	P26927
PRAAFPGLGHLVSLH	CHADL	441	Q6NUI6
GSAVPVRFHLHPEGL	FAM215A	46	Q9Y5M1
LQLAEHPHALAGRPG	HELZ2	1776	Q9BYK8
LLGTEPAEAFHPHLP	CAND2	506	O75155
PTLPDGLLGLSHLVL	CEP295	1436	Q9C0D2
AQLLHALEDAHLPGP	RYR1	1691	P21817
GHPAQEHFPKLLGLL	IPO4	931	Q8TEX9
LIAGLPAVPEHEHSP	PEX1	666	O43933
HPGLVRGDTPELAEH	POU3F3	256	P20264
LLGQEGVSLPSHLPL	CREB3L4	196	Q8TEY5
FHGPGQLLCHPVLDL	LIPT2	91	A6NK58
GIPGEALPFIHHELS	OSGIN1	256	Q9UJX0
GLVPLGPHDALLSHV	PIDD1	366	Q9HB75
GPHDALLSHVLELQP	PIDD1	371	Q9HB75
VGLHHPPQLGAPLFL	OR10G6	36	Q8NH81
HPHPELLLRGGAAAA	FOXD2	236	O60548
PGIVHRSIGLPDVHS	RTCB	76	Q9Y3I0
ALGHALPVAAPGARH	RTBDN	166	Q9BSG5
LEHFRVHPIPLESGG	SH2B1	601	Q9NRF2
GHLGHIELPLTVYNP	POLR1A	76	O95602
PAVPPLHVLGDGHLS	RNF157	381	Q96PX1
GVLPDSGHLHPLLKV	FARSA	216	Q9Y285
AGAEGLPLHVALHPP	TMEM132A	731	Q24JP5
HLLGHLEQAKSLPPG	PRDM15	581	P57071
FLQHGTLVGLLPVPH	HID1	726	Q8IV36
LPIYTPLTHHGELTG	INPP5D	831	Q92835
LTHLGLGENLLTHLP	SHOC2	496	Q9UQ13
GPLPATHLRHLGEVV	MUTYH	426	Q9UIF7
GLGVHHSGILPILKE	SKIV2L	631	Q15477
FALPTAHHTLGLPVG	CYB5R1	66	Q9UHQ9
LAHLLVLPGGFGPIS	STRC	1636	Q7RTU9
DGLLHGLTVPQLPVH	STK36	621	Q9NRP7
GTLLLLQPPARGHAH	ROBO4	86	Q8WZ75
DHIAHIVELLGDIPP	SRPK3	476	Q9UPE1
VLPILHGLGTDSHLV	ARAP1	1241	Q96P48
LALGSSLAPVHVPLG	CEP164	131	Q9UPV0
GHSARHDTLPVPLAG	CHRD	526	Q9H2X0
HALGHTALPGLLLSL	RHBDD3	56	Q9Y3P4
TFLAGHPLHLVAATP	ZNF804B	1261	A4D1E1
STLLIVPDHPEHGVL	VPS35L	781	Q7Z3J2
LALPPLFGGHILESE	TFPT	26	P0C1Z6
AEAGLHVSALGPHPP	TBX2	71	Q13207
SILGHVIHGGIVLPL	SLC1A4	301	P43007
LGDAFLHLIPHALEP	SLC39A7	181	Q92504
AFHRVGPPLLIEHLG	TMEM158	116	Q8WZ71
LHALEPAGHNLLGPA	STPG3	311	Q8N7X2
VLTHALPGDPGHILT	TOMT	86	Q8WZ04
LTFGDIPHHAPVLLA	NUP188	311	Q5SRE5
KHGLSPLEVVLHRPG	RGS14	406	O43566
LLHEGPGSSLLLPAA	SIGLEC1	551	Q9BZZ2
VLGVFGELDLHGIPH	PKHD1L1	3151	Q86WI1
HLLHLPGLGAPVEVV	PIGZ	471	Q86VD9
LGLLAHAHGLPQLLG	TMEM82	191	A0PJX8
HAHGLPQLLGRALAI	TMEM82	196	A0PJX8
LCEHLPGPHTSLLLG	TTC21A	721	Q8NDW8
LGGAHGLLERPELQH	ZNF469	3356	Q96JG9
LCPVLGAHRGHPVGL	TRIM14	46	Q14142
LPEPSLLHLGDHEAS	TOX2	86	Q96NM4
AHLTRTLGHELPGPA	TCF23	126	Q7RTU1
GAPLISLDPAHRDHL	VSIG10L	241	Q86VR7
GHHQPPGGLESPLLL	ZFP36L2	266	P47974
HVPHTRLLVTSGLPG	WDR73	91	Q6P4I2
LITAAHELGVAHPPG	TMEM260	56	Q9NX78
AKVLVPGIPGHHAAI	WDR43	401	Q15061
LAVPLLLHALSLPHG	UNC79	1026	Q9P2D8
HLRLHPELSGPGVAA	ZNF787	196	Q6DD87
IDSGIVPHLVPLLSH	KPNA4	281	O00629
TSGHLLCGGVLIHPL	KLK6	41	Q92876
HSLHQRGLAVPDGPL	KIAA1522	446	Q9P206