Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	regulation of neuron differentiation	MYCN HEYL TIAM1 HEY1 TRPC5 ASPM ARHGEF2	2.07e-05	255	68	7	GO:0045664
GeneOntologyBiologicalProcess	regulation of neurogenesis	MYCN HEYL TIAM1 HEY1 PTPRS TRPC5 ASPM ARHGEF2 CUX1	4.68e-05	515	68	9	GO:0050767
Domain	TMEM191C	TMEM191B TMEM191C	1.35e-05	2	69	2	PF15194
Domain	TMEM191B/C	TMEM191B TMEM191C	1.35e-05	2	69	2	IPR028186
Domain	-	MYCN TCF23 HEYL BHLHE23 HEY1	5.15e-05	109	69	5	4.10.280.10
Domain	HLH	MYCN TCF23 HEYL BHLHE23 HEY1	5.62e-05	111	69	5	PF00010
Domain	HLH	MYCN TCF23 HEYL BHLHE23 HEY1	6.94e-05	116	69	5	SM00353
Domain	BHLH	MYCN TCF23 HEYL BHLHE23 HEY1	7.23e-05	117	69	5	PS50888
Domain	bHLH_dom	MYCN TCF23 HEYL BHLHE23 HEY1	7.52e-05	118	69	5	IPR011598
Domain	CH	SPTBN5 SYNE2 ASPM SPECC1L	9.75e-05	65	69	4	SM00033
Domain	CH	SPTBN5 SYNE2 ASPM SPECC1L	1.30e-04	70	69	4	PF00307
Domain	-	SPTBN5 SYNE2 ASPM SPECC1L	1.38e-04	71	69	4	1.10.418.10
Domain	CH	SPTBN5 SYNE2 ASPM SPECC1L	1.53e-04	73	69	4	PS50021
Domain	CH-domain	SPTBN5 SYNE2 ASPM SPECC1L	1.70e-04	75	69	4	IPR001715
Domain	ORANGE	HEYL HEY1	4.76e-04	9	69	2	SM00511
Domain	Hairy_orange	HEYL HEY1	8.67e-04	12	69	2	PF07527
Domain	Orange_dom	HEYL HEY1	8.67e-04	12	69	2	IPR003650
Domain	ORANGE	HEYL HEY1	1.02e-03	13	69	2	PS51054
Domain	PDZ	TIAM1 SIPA1L1 DVL2 AHNAK2	1.84e-03	141	69	4	PF00595
Domain	PDZ	TIAM1 SIPA1L1 DVL2 AHNAK2	2.20e-03	148	69	4	SM00228
Domain	-	TIAM1 SIPA1L1 DVL2 AHNAK2	2.31e-03	150	69	4	2.30.42.10
Domain	PDZ	TIAM1 SIPA1L1 DVL2 AHNAK2	2.36e-03	151	69	4	PS50106
Domain	PDZ	TIAM1 SIPA1L1 DVL2 AHNAK2	2.42e-03	152	69	4	IPR001478
Domain	Actinin_actin-bd_CS	SPTBN5 SYNE2	3.24e-03	23	69	2	IPR001589
Domain	Spectrin	SPTBN5 SYNE2	3.24e-03	23	69	2	PF00435
Domain	ACTININ_2	SPTBN5 SYNE2	3.24e-03	23	69	2	PS00020
Domain	ACTININ_1	SPTBN5 SYNE2	3.24e-03	23	69	2	PS00019
Domain	BRCT	ENGASE MDC1	4.13e-03	26	69	2	PS50172
Domain	HECT	UBE3B HACE1	4.45e-03	27	69	2	PF00632
Domain	HECTc	UBE3B HACE1	4.45e-03	27	69	2	SM00119
Domain	HECT_dom	UBE3B HACE1	4.45e-03	27	69	2	IPR000569
Domain	HECT	UBE3B HACE1	4.45e-03	27	69	2	PS50237
Domain	BRCT_dom	ENGASE MDC1	4.78e-03	28	69	2	IPR001357
Domain	Spectrin_repeat	SPTBN5 SYNE2	5.12e-03	29	69	2	IPR002017
Domain	Ig_I-set	BOC HMCN2 PTPRS SPEG	5.36e-03	190	69	4	IPR013098
Domain	I-set	BOC HMCN2 PTPRS SPEG	5.36e-03	190	69	4	PF07679
Domain	Spectrin/alpha-actinin	SPTBN5 SYNE2	6.21e-03	32	69	2	IPR018159
Domain	SPEC	SPTBN5 SYNE2	6.21e-03	32	69	2	SM00150
Domain	Ank_2	TRPC5 HACE1 DAPK1 PPP1R16A	8.24e-03	215	69	4	PF12796
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TYK2 ENGASE SETD1A HEYL ARAP3 PTPRS SPEG UBE3B ATG2A ARHGEF2 CABLES1 AHNAK2 PPP1R16A	3.30e-07	1105	71	13	35748872
Pubmed	Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation.	MYCN TCF23 HEYL BHLHE23 HEY1	1.80e-06	98	71	5	18557763
Pubmed	Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy.	MYCN HEYL HEY1	9.06e-06	20	71	3	23314057
Pubmed	Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis.	HEYL HEY1	1.23e-05	3	71	2	10415358
Pubmed	Hesr, a mediator of the Notch signaling, functions in heart and vessel development.	HEYL HEY1	1.23e-05	3	71	2	16165016
Pubmed	CYP1B1 promotes tumorigenesis via altered expression of CDC20 and DAPK1 genes in renal cell carcinoma.	CYP1B1 DAPK1	1.23e-05	3	71	2	26626260
Pubmed	HES and HERP families: multiple effectors of the Notch signaling pathway.	HEYL HEY1	1.23e-05	3	71	2	12548545
Pubmed	Clinical manifestations of hyper IgE syndromes.	TYK2 DOCK8	1.23e-05	3	71	2	21178271
Pubmed	Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors.	TIAM1 ARHGEF2	2.46e-05	4	71	2	11595749
Pubmed	Regulation of sphingosine 1-phosphate-induced endothelial cytoskeletal rearrangement and barrier enhancement by S1P1 receptor, PI3 kinase, Tiam1/Rac1, and alpha-actinin.	TIAM1 S1PR1	2.46e-05	4	71	2	16195373
Pubmed	Differential effects of the HESR/HEY transcription factor family on dopamine transporter reporter gene expression via variable number of tandem repeats.	HEYL HEY1	2.46e-05	4	71	2	21290414
Pubmed	Cell-autonomous and redundant roles of Hey1 and HeyL in muscle stem cells: HeyL requires Hes1 to bind diverse DNA sites.	HEYL HEY1	2.46e-05	4	71	2	30745427
Pubmed	Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism.	HEYL HEY1	2.46e-05	4	71	2	15485867
Pubmed	Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family.	HEYL HEY1	2.46e-05	4	71	2	10860664
Pubmed	Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle.	HEYL HEY1	2.46e-05	4	71	2	31545169
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	SETD1A MDC1 RECQL4 SPECC1L MIDEAS SLX4 EZHIP	3.94e-05	453	71	7	29656893
Pubmed	The basic helix-loop-helix gene hesr2 promotes gliogenesis in mouse retina.	HEYL HEY1	4.09e-05	5	71	2	11160397
Pubmed	Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors.	HEYL HEY1	4.09e-05	5	71	2	21454491
Pubmed	Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling.	HEYL HEY1	4.09e-05	5	71	2	11095750
Pubmed	Sox9 Inhibits Cochlear Hair Cell Fate by Upregulating Hey1 and HeyL Antagonists of Atoh1.	HEYL HEY1	4.09e-05	5	71	2	37681879
Pubmed	HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments.	HEYL HEY1	4.09e-05	5	71	2	10588864
Pubmed	Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning.	RFX4 CUX1	4.09e-05	5	71	2	24531968
Pubmed	A genome-wide association study identifies susceptibility loci for Wilms tumor.	MYCN NHS	6.13e-05	6	71	2	22544364
Pubmed	HeyL promotes neuronal differentiation of neural progenitor cells.	HEYL HEY1	6.13e-05	6	71	2	21259317
Pubmed	Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes.	HEYL HEY1	8.57e-05	7	71	2	10964718
Pubmed	MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC.	TRPC5 MX1	8.57e-05	7	71	2	15757897
Pubmed	Homozygous ARHGEF2 mutation causes intellectual disability and midbrain-hindbrain malformation.	ARHGEF2 CUX1	8.57e-05	7	71	2	28453519
Pubmed	Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts.	HEYL HEY1	8.57e-05	7	71	2	16199874
Pubmed	The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function.	HEYL HEY1	8.57e-05	7	71	2	10924525
Pubmed	Direct cDNA selection with DNA microdissected from mouse chromosome 16: isolation of novel clones and construction of a partial transcription map of the C3-C4 region.	TIAM1 MX1	8.57e-05	7	71	2	8858343
Pubmed	Hey bHLH Proteins Interact with a FBXO45 Containing SCF Ubiquitin Ligase Complex and Induce Its Translocation into the Nucleus.	HEYL HEY1	8.57e-05	7	71	2	26068074
Pubmed	A census of human transcription factors: function, expression and evolution.	MYCN TCF23 HEYL BHLHE23 HOXC12 HEY1 MIDEAS RFX4 ZC3H3	9.48e-05	908	71	9	19274049
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	MYCN BHLHE23 HOXC12 HEY1 ZNF75A RFX4 CUX1	1.23e-04	544	71	7	28473536
Pubmed	SORBS2 is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients.	HEYL HEY1	1.47e-04	9	71	2	34099102
Pubmed	Polycystic kidneys caused by sustained expression of Cux1 isoform p75.	MYCN CUX1	1.47e-04	9	71	2	18356167
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	PTPRS SIPA1L1 SYNE2 DVL2 GRIA1 DAPK1 SPECC1L ARHGEF2 CUX1	1.48e-04	963	71	9	28671696
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	CYP1B1 BHLHE23 SIPA1L1 SYNE2 MDC1 DGKE SPECC1L ARHGEF2 CUX1 MX1 AHNAK2	1.54e-04	1440	71	11	30833792
Pubmed	Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.	CCP110 SIPA1L1 ATG2A	1.68e-04	52	71	3	9455477
Pubmed	Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochlea.	HEYL HEY1	1.83e-04	10	71	2	18291358
Pubmed	Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons.	TIAM1 DVL2	1.83e-04	10	71	2	23109420
Pubmed	Wnt signaling and its downstream target N-myc regulate basal progenitors in the developing neocortex.	MYCN CUX1	1.83e-04	10	71	2	20215343
Pubmed	Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2.	HEYL HEY1	1.83e-04	10	71	2	25733872
Pubmed	Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization.	GRIA1 CUX1	2.23e-04	11	71	2	25232112
Pubmed	Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development.	MYCN HEY1	2.23e-04	11	71	2	25848000
Pubmed	HeyL regulates the number of TrkC neurons in dorsal root ganglia.	HEYL HEY1	2.23e-04	11	71	2	19631204
Pubmed	Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers.	HEYL HEY1	2.23e-04	11	71	2	21989910
Pubmed	Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer.	HEYL HEY1	2.23e-04	11	71	2	17611704
Pubmed	Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening.	TCF23 BHLHE23	2.68e-04	12	71	2	14516699
Pubmed	Perivascular cells support folliculogenesis in the developing ovary.	HEYL HEY1	2.68e-04	12	71	2	36194632
Pubmed	Myocardial Notch1-Rbpj deletion does not affect NOTCH signaling, heart development or function.	HEYL HEY1	2.68e-04	12	71	2	30596653
Pubmed	Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial.	TYK2 MX1	3.16e-04	13	71	2	19434718
Pubmed	Genome-wide and candidate gene association study of cigarette smoking behaviors.	TRPC5 CABLES1	3.16e-04	13	71	2	19247474
Pubmed	Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome.	TIAM1 MX1	3.16e-04	13	71	2	8812055
Pubmed	HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development.	HEYL HEY1	3.16e-04	13	71	2	27160681
Pubmed	The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability.	GRIA1 CUX1	3.16e-04	13	71	2	31841517
Pubmed	Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate.	ASPM CUX1	3.68e-04	14	71	2	27974163
Pubmed	SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.	SYNE2 CUX1	3.68e-04	14	71	2	19874786
Pubmed	Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells.	MYCN HEY1	3.68e-04	14	71	2	21349854
Pubmed	The murine ortholog of Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc.	UBE3B CUX1	3.68e-04	14	71	2	32249816
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	SELENOS SYNE2 DDRGK1 DGKE ATG2A GRAMD1C	3.93e-04	468	71	6	31056421
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	SETD1A ARAP3 MDC1 RECQL4 NIPSNAP1 ASPM DDX51 ARHGEF2 MIDEAS AHNAK2	4.10e-04	1353	71	10	29467282
Pubmed	Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants.	HEYL HEY1	4.24e-04	15	71	2	17194759
Pubmed	Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.	HEYL HEY1	4.24e-04	15	71	2	14672936
Pubmed	Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development.	HEYL HEY1	4.24e-04	15	71	2	12971992
Pubmed	LKB1 and Notch Pathways Interact and Control Biliary Morphogenesis.	HEYL HEY1	4.24e-04	15	71	2	26689699
Pubmed	Notch pathway targets proangiogenic regulator Sox17 to restrict angiogenesis.	HEYL HEY1	4.24e-04	15	71	2	24755984
Pubmed	Notch signaling regulates remodeling and vessel diameter in the extraembryonic yolk sac.	HEYL HEY1	4.84e-04	16	71	2	21352545
Pubmed	Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling.	HEY1 DAPK1	4.84e-04	16	71	2	16061358
Pubmed	Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo.	HEYL HEY1	4.84e-04	16	71	2	22069191
Pubmed	Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development.	HEYL HEY1	4.84e-04	16	71	2	21300049
Pubmed	An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.	HEYL HEY1	4.84e-04	16	71	2	17273555
Pubmed	Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.	MDC1 SLX4	4.84e-04	16	71	2	27760317
Pubmed	Persistent expression of activated Notch inhibits corticotrope and melanotrope differentiation and results in dysfunction of the HPA axis.	HEYL HEY1	5.48e-04	17	71	2	21781958
Pubmed	Segmental expression of Notch and Hairy genes in nephrogenesis.	HEYL HEY1	5.48e-04	17	71	2	15821257
Pubmed	Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1.	HEYL HEY1	5.48e-04	17	71	2	22457635
Pubmed	Notch signalling in the paraxial mesoderm is most sensitive to reduced Pofut1 levels during early mouse development.	HEYL HEY1	5.48e-04	17	71	2	19161597
Pubmed	ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination.	ASPM CUX1	5.48e-04	17	71	2	26581405
Pubmed	RBPJ in mouse Sertoli cells is required for proper regulation of the testis stem cell niche.	HEYL HEY1	5.48e-04	17	71	2	25406395
Pubmed	Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors.	HEYL HEY1	5.48e-04	17	71	2	22615585
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	SPTBN5 DNHD1 SYNE2 CUX1	5.94e-04	187	71	4	26460568
Pubmed	GSK-3 signaling in developing cortical neurons is essential for radial migration and dendritic orientation.	DVL2 CUX1	6.16e-04	18	71	2	25073924
Pubmed	Chloride intracellular channel 4 is required for maturation of the cerebral collateral circulation.	HEY1 S1PR1	6.16e-04	18	71	2	26276819
Pubmed	Presenilin enhancer 2 is crucial for the transition of apical progenitors into neurons but into not basal progenitors in the developing hippocampus.	HEY1 CUX1	6.87e-04	19	71	2	35575074
Pubmed	RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development.	HEYL HEY1	6.87e-04	19	71	2	20335360
Pubmed	Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves.	HEYL HEY1	6.87e-04	19	71	2	25691540
Pubmed	The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration.	DOCK8 MDC1 GRIA1 DAPK1	7.49e-04	199	71	4	36688959
Pubmed	Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas.	HEYL HEY1	7.62e-04	20	71	2	19501159
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SYNE2 SPECC1L ARHGEF2	7.64e-04	87	71	3	12465718
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	ARAP3 TIAM1 SPECC1L ARHGEF2	7.92e-04	202	71	4	33005030
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	CCP110 PDE7A PTPRS RECQL4 HACE1 DAPK1 SPECC1L ARHGEF2 PPP1R16A	8.01e-04	1215	71	9	15146197
Pubmed	The Schizophrenia Susceptibility Gene OPCML Regulates Spine Maturation and Cognitive Behaviors through Eph-Cofilin Signaling.	GRIA1 CUX1	8.41e-04	21	71	2	31577955
Pubmed	Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition.	HEYL HEY1	8.41e-04	21	71	2	17303760
Pubmed	The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain.	MYCN CUX1	8.41e-04	21	71	2	19686682
Pubmed	Ephrin-B2 governs morphogenesis of endolymphatic sac and duct epithelia in the mouse inner ear.	HEYL HEY1	8.41e-04	21	71	2	24583262
Pubmed	Disruption of sorting nexin 5 causes respiratory failure associated with undifferentiated alveolar epithelial type I cells in mice.	HEYL HEY1	8.41e-04	21	71	2	23526992
Pubmed	The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.	HACE1 DGKE CABLES1	8.71e-04	91	71	3	20546612
Pubmed	Impaired fetal muscle development and JAK-STAT activation mark disease onset and progression in a mouse model for merosin-deficient congenital muscular dystrophy.	HEYL HEY1	9.24e-04	22	71	2	28334989
Pubmed	The rho GTPase Rac1 is required for proliferation and survival of progenitors in the developing forebrain.	MYCN CUX1	9.24e-04	22	71	2	20506362
Pubmed	Sequential Notch activation regulates ventricular chamber development.	HEYL HEY1	9.24e-04	22	71	2	26641715
Pubmed	The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.	BHLHE23 HEY1 TRPC5 ASPM	9.47e-04	212	71	4	19521566
Interaction	TOP3B interactions	TYK2 ENGASE MYCN SETD1A HEYL ARAP3 PTPRS SPEG UBE3B MDC1 NIPSNAP1 DVL2 DDRGK1 ATG2A ARHGEF2 CABLES1 AHNAK2 PPP1R16A	7.22e-07	1470	66	18	int:TOP3B
Interaction	ZNF333 interactions	TYK2 RECQL4 DVL2 ASPM	1.06e-06	24	66	4	int:ZNF333
Interaction	GTF3C5 interactions	MDC1 RECQL4 NIPSNAP1 DVL2 DDRGK1 SLX4	1.45e-05	161	66	6	int:GTF3C5
Interaction	CEP78 interactions	CCP110 RECQL4 DVL2 ASPM DDRGK1	1.57e-05	96	66	5	int:CEP78
Interaction	ZNF207 interactions	MYCN SETD1A MDC1 RECQL4 DDRGK1	3.17e-05	111	66	5	int:ZNF207
Interaction	ZNF251 interactions	MDC1 DVL2 MX1	4.28e-05	21	66	3	int:ZNF251
Interaction	YWHAQ interactions	MYCN CCP110 REM1 TIAM1 SPEG SIPA1L1 RECQL4 DVL2 DDRGK1 NHS DAPK1 SPECC1L ARHGEF2	5.76e-05	1118	66	13	int:YWHAQ
GeneFamily	Basic helix-loop-helix proteins	MYCN TCF23 HEYL BHLHE23 HEY1	1.06e-05	110	48	5	420
GeneFamily	PDZ domain containing	TIAM1 SIPA1L1 DVL2 AHNAK2	7.01e-04	152	48	4	1220
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	BOC HMCN2 PTPRS SPEG	8.69e-04	161	48	4	593
GeneFamily	Ankyrin repeat domain containing	ARAP3 HACE1 DAPK1 PPP1R16A	3.84e-03	242	48	4	403
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	TIAM1 ARHGEF2	1.33e-02	66	48	2	722
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BOC HEYL REM1 HMCN2 LONRF2	9.40e-06	177	71	5	bd602db857f37869ef76d14c05ef522c509f08ee
ToppCell	3'_v3-lymph-node_spleen-Hematopoietic_progenitors-Progenitor_pre-Lymphocytic-T\|lymph-node_spleen / Manually curated celltypes from each tissue	ENGASE MYCN CCP110 AZU1 MDC1	1.10e-05	183	71	5	6c55fd737ed31f5b1aa41dc4dba7240521c19022
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D231\|Adult / Lineage, Cell type, age group and donor	BOC CYP1B1 HMCN2 PTPRS PODN	1.16e-05	185	71	5	fb6bd7e849ecf4ed9cd9c4e2a946a2d12d62f804
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BOC CYP1B1 HMCN2 PTPRS PODN	1.26e-05	188	71	5	ce85a56ac27a6432421dde93a1bafa8b943244b9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BOC CYP1B1 HMCN2 PTPRS PODN	1.32e-05	190	71	5	efb757f11c2809e66ddb48a5c84f5433f111cb7c
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BOC PTPRS SPEG GRIA1 LONRF2	1.36e-05	191	71	5	b133ee1c0e58d00ddd2e4e05b01fd04947524c18
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	PDE7A SIPA1L1 SYNE2 NHS CUX1	1.39e-05	192	71	5	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	COVID-19-kidney-Glomerular_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	BOC ARAP3 F2RL3 SYNE2 DGKE	1.46e-05	194	71	5	660535b492445063d965095a50e1e299ce04c50a
ToppCell	3'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYCN CYP1B1 FUT11 TIAM1 DAPK1	1.50e-05	195	71	5	6a0460d949ccda7c9fe76870d3ee6c2f60677d61
ToppCell	droplet-Bladder-nan-24m-Endothelial\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEYL ARAP3 HEY1 SPEG S1PR1	1.54e-05	196	71	5	9a90dd26e7a43e3fd55e7c5d8354cfa4cdd5a6cc
ToppCell	COPD-Stromal-Fibroblast\|Stromal / Disease state, Lineage and Cell class	CYP1B1 SH3TC2 TIAM1 PODN LONRF2	1.54e-05	196	71	5	4930eeb303d174c28fd91021723e26fdf1af9170
ToppCell	droplet-Bladder-nan-24m-Endothelial-endothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEYL ARAP3 HEY1 SPEG S1PR1	1.54e-05	196	71	5	04dfef1bd4ebb0e9469ae80024dc177e469a2560
ToppCell	droplet-Bladder-nan-24m-Endothelial-endothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEYL ARAP3 HEY1 SPEG S1PR1	1.58e-05	197	71	5	488e85991c5e668afb7672942726d9295b8fc7d8
ToppCell	LPS-antiTNF-Epithelial_alveolar-Mes-Like-Differentiating_AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ACP6 HMCN2 SPEG LONRF2	5.24e-05	128	71	4	2cf0384240a4a663869cf6b27d954236f6214a9a
ToppCell	Endothelial-B-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	MYCN ARAP3 F2RL3 S1PR1	1.40e-04	165	71	4	b6893882472aeb0d18e26f47eaec9d53688afcde
ToppCell	facs-Spleen-nan-18m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3TC2 REM1 ASPM HMBS	1.43e-04	166	71	4	8d535fab019356894b4dad3fbdbc4d2ad3e16082
ToppCell	facs-Spleen-nan-18m-Hematologic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3TC2 REM1 ASPM HMBS	1.43e-04	166	71	4	f56b1c0d6cb5353a16a2598bda905287f16d2c39
ToppCell	facs-Spleen-nan-18m-Hematologic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3TC2 REM1 ASPM HMBS	1.43e-04	166	71	4	a5074c96c6561273029aceb93402a7e038140f50
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ARAP3 HEY1 F2RL3 S1PR1	1.50e-04	168	71	4	55c9de7b3a1d6cf7b02b020ff92ab4ede8d195cc
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-8\|TCGA-Thryoid / Sample_Type by Project: Shred V9	FUT11 ARAP3 TRPC5 LONRF2	1.50e-04	168	71	4	00646601548b0fee42ae16bfa5e93603bc7c5129
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARAP3 HMCN2 SPEG S1PR1	1.53e-04	169	71	4	c7fc3a8c44f07c557b60d469717b66e2f5863d38
ToppCell	droplet-Lung-1m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l21\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	F2RL3 RECQL4 NHS GRAMD1C	1.64e-04	172	71	4	30f4979abf0218618a56afb06aa6afc23ad838ec
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-early_pro_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEYL SH3TC2 HEY1 NHS	1.79e-04	176	71	4	7292e014b8f697f0c2e9f47c48333de95cb44a69
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-early_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEYL SH3TC2 HEY1 NHS	1.79e-04	176	71	4	88ca2f83d8301633232735f39b0683efe49d0b86
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARAP3 HEY1 DGKE S1PR1	1.87e-04	178	71	4	5f779a66aa42d1d8e8af17b4a08d5dcc733efd4c
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ARAP3 HEY1 ASPM S1PR1	1.95e-04	180	71	4	b35a8c6169f4b548b912af005e92ae7c6596f376
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASPM GRIA1 PODN RFX4	2.04e-04	182	71	4	904804813849b7f7f716ba1554d33b07bc0a701e
ToppCell	E18.5-samps-Endothelial-Mature_fetal_endothelial-endothelial_cells_A\|E18.5-samps / Age Group, Lineage, Cell class and subclass	ARAP3 HEY1 PODN S1PR1	2.04e-04	182	71	4	ea4f6c8f600ffe9f8e0609637b3371a5ac48ca03
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BOC SH3TC2 DOCK8 DAPK1	2.04e-04	182	71	4	5e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ENGASE HMCN2 ASPM NHS	2.04e-04	182	71	4	08aff7112c9dac0ef5540300516a604782b21169
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASPM GRIA1 PODN RFX4	2.04e-04	182	71	4	5d8b7fe18286e27f0f50c5d2d9be56850e2cb8f4
ToppCell	3'-Adult-SmallIntestine-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CYP1B1 HEY1 F2RL3 S1PR1	2.08e-04	183	71	4	858682df5592c6856487487a7baabd6e60e63a38
ToppCell	3'-Adult-SmallIntestine-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CYP1B1 HEY1 F2RL3 S1PR1	2.08e-04	183	71	4	f8212bf8a8b8312434ae030261c558c147f61747
ToppCell	3'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CYP1B1 HEY1 S1PR1 AHNAK2	2.17e-04	185	71	4	fa94c4a1660967f211ba095606cd0aa37d38e17a
ToppCell	COVID-19_Moderate-NK_activated\|World / disease group, cell group and cell class	FUT11 SYNE2 PODN MX1	2.21e-04	186	71	4	ff8f32f69516bf785224fa12f8139a95359b0279
ToppCell	5'-GW_trimst-2-LymphNode-Mesenchymal-Pericytes\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TCF23 HEYL BHLHE23 REM1	2.21e-04	186	71	4	1e3ab663e4756975db6d802b2c6c054a94a79393
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TIAM1 TRPC5 ASPM NHS	2.21e-04	186	71	4	6379609b7ace80683f5754b16aa77f11b43766ae
ToppCell	3'-Adult-Appendix-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CYP1B1 HEY1 S1PR1 AHNAK2	2.26e-04	187	71	4	37d8ee5c8bd6324749e5a2adef1d0482c75da80c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BOC SPTBN5 ARAP3 F2RL3	2.26e-04	187	71	4	35c382c0aabd46906113e5db30ea24bb8e658899
ToppCell	droplet-Pancreas-Exocrine-24m-Endothelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCN ARAP3 HEY1 S1PR1	2.26e-04	187	71	4	a178b1fed80a0bf83aedb6262493ee17374734b5
ToppCell	3'-Adult-Appendix-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CYP1B1 HEY1 S1PR1 AHNAK2	2.26e-04	187	71	4	ec98d5e480b08854dfd0ba6b1dc6610455f90640
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BOC CYP1B1 HEYL PODN	2.26e-04	187	71	4	ed7ab4cf4629d96dad5c74d536fc428d0a8d4eb9
ToppCell	droplet-Pancreas-Exocrine-24m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCN ARAP3 HEY1 S1PR1	2.26e-04	187	71	4	e60cbccf5842f25123fd34b9475759b7424b32e9
ToppCell	droplet-Pancreas-Exocrine-24m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCN ARAP3 HEY1 S1PR1	2.26e-04	187	71	4	2b8eda2812be0be68a6f01aa4038925d3d5b1e65
ToppCell	COVID-19-Heart-Fib_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	BOC CYP1B1 HEYL HMCN2	2.31e-04	188	71	4	fe361215f4ba841aa5e1e581fb56f2f4d3ccd201
ToppCell	droplet-Pancreas-Endocrine-21m-Endothelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	REM1 ARAP3 F2RL3 S1PR1	2.35e-04	189	71	4	37ce47abd6f96df04d35a4a6189d007bef5ccc94
ToppCell	droplet-Pancreas-Endocrine-21m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	REM1 ARAP3 F2RL3 S1PR1	2.35e-04	189	71	4	b55324cb365a827d071952709bbf0e8ef8c313de
ToppCell	droplet-Pancreas-Endocrine-21m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	REM1 ARAP3 F2RL3 S1PR1	2.35e-04	189	71	4	62e46d59d3b89d4566b595c704d8b02f1ea9060b
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BOC PTPRS SPEG LONRF2	2.35e-04	189	71	4	45e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARAP3 HEY1 DGKE S1PR1	2.40e-04	190	71	4	bf9bc57a605c7e3979bc4f7260e6fb92c3eb8690
ToppCell	facs-SCAT-Fat-24m-Mesenchymal-mesenchymal_progenitor\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC CYP1B1 PODN DAPK1	2.40e-04	190	71	4	dc7e92f1b18d0f5efec11d09d56ba954d4f8b3bd
ToppCell	facs-SCAT-Fat-24m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC CYP1B1 PODN DAPK1	2.40e-04	190	71	4	0bb06df3d5a50416854370f234718c6cec3d773b
ToppCell	facs-SCAT-Fat-24m-Mesenchymal\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC CYP1B1 PODN DAPK1	2.40e-04	190	71	4	008290bb5c79446681dd6bf354336c57ad0d6f13
ToppCell	PND01-03-samps-Endothelial\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	ARAP3 HEY1 PODN S1PR1	2.40e-04	190	71	4	1357bd4527399d7013ee33272bda7453f472999a
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	ARAP3 HEY1 PODN S1PR1	2.40e-04	190	71	4	5130fb325f80f591b9b36beacb8072c4472304f2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CYP1B1 TCF23 HEYL PODN	2.40e-04	190	71	4	7f6dafd5418764d67f6d5ec2153233b791910e81
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BOC CYP1B1 HEYL PODN	2.45e-04	191	71	4	b51e0f5d1b93f526160c904e9091313a5364f3a7
ToppCell	5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CYP1B1 HEY1 SYNE2 S1PR1	2.45e-04	191	71	4	adb2e3efcad02889d8229325080da5e7830fd3ae
ToppCell	PND01-03-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	BOC REM1 PTPRS SPECC1L	2.45e-04	191	71	4	e7c605b56934d1383237c1f946dbccef25d91368
ToppCell	facs-Aorta-Heart-18m\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP1B1 HEYL SELENOS PODN	2.45e-04	191	71	4	6242f83acaf1714e9c1771a832cb67674b19e96d
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYP1B1 HEYL PODN AHNAK2	2.45e-04	191	71	4	9f478f36a0b895e607e3bb77fa0f9f03cc0f33fc
ToppCell	5'-Adult-LymphNode-Mesenchymal\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BOC HEYL PODN LONRF2	2.45e-04	191	71	4	054e9a79bd1486fd812bc7418fb091664fe3a646
ToppCell	facs-Aorta-Heart-18m-Mesenchymal\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP1B1 HEYL SELENOS PODN	2.50e-04	192	71	4	6d4fe7ea278efa4b9d43f8a3c282bc0e0e9abaea
ToppCell	RV-08._Macrophage\|World / Chamber and Cluster_Paper	DOCK8 SIPA1L1 ASPM DAPK1	2.50e-04	192	71	4	a1b5dc5beb97a23729b97b54fb4574d10d8fbfb3
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC CYP1B1 REM1 PODN	2.50e-04	192	71	4	8937a59f6bbe07f671bdabbd3707dc9c17a14cd9
ToppCell	facs-Aorta-Heart-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP1B1 HEYL SELENOS PODN	2.50e-04	192	71	4	2c6406bc97c3224099b94a43f2890f057b528fa6
ToppCell	H1299-infected\|H1299 / Cell line, Condition and Strain	RECQL4 ASPM DDX51 AHNAK2	2.50e-04	192	71	4	9cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC CYP1B1 REM1 PODN	2.50e-04	192	71	4	e4a7f2673f801b008ca67291db2fb2b9fd2955b8
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC CYP1B1 REM1 PODN	2.50e-04	192	71	4	ac1477433704573f95111eee6263b93668d2845e
ToppCell	droplet-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SH3TC2 ARAP3 HEY1 S1PR1	2.50e-04	192	71	4	6b69bb8fab9b470850eba1a070a500435ec233cd
ToppCell	facs-Aorta-Heart-18m-Mesenchymal-nan\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP1B1 HEYL SELENOS PODN	2.50e-04	192	71	4	47aed7c8e6f5ce1084821212a04f568319e65fd6
ToppCell	droplet-Lung-nan-3m-Endothelial-Capillary_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3TC2 ARAP3 HEY1 S1PR1	2.55e-04	193	71	4	7cff1e859b296b1032eebcfc0f99a504f3bda2c9
ToppCell	droplet-Lung-3m-Endothelial-capillary_endothelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SH3TC2 ARAP3 HEY1 S1PR1	2.55e-04	193	71	4	1b6317b740cad2439f08b9e9895426d861e7a161
ToppCell	RV-08._Macrophage\|RV / Chamber and Cluster_Paper	DOCK8 SIPA1L1 ASPM DAPK1	2.55e-04	193	71	4	12bf98a280f87e4d8f0c6887dfc855da72e47ac1
ToppCell	droplet-Bladder-nan-3m-Endothelial-endothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEYL ARAP3 HEY1 S1PR1	2.55e-04	193	71	4	8be24713f8ba2545b7647d1994e9e993623ddaa3
ToppCell	droplet-Bladder-nan-3m-Endothelial-endothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEYL ARAP3 HEY1 S1PR1	2.55e-04	193	71	4	19dfc4a2c91fcea4f5991e7c44df46faeecb06b8
ToppCell	droplet-Bladder-nan-3m-Endothelial\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEYL ARAP3 HEY1 S1PR1	2.55e-04	193	71	4	351e0acd411a9eb0dbc0e358d0d1e3759753fa40
ToppCell	droplet-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SH3TC2 ARAP3 HEY1 S1PR1	2.55e-04	193	71	4	f5861cfa4401b476229a7c61cd64abad79a4bbfc
ToppCell	droplet-Lung-3m-Endothelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SH3TC2 ARAP3 HEY1 S1PR1	2.55e-04	193	71	4	95c9c63bddfed1a84393ccd3578cfe65bc0c1c05
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-10\|TCGA-Colorectal / Sample_Type by Project: Shred V9	BOC CYP1B1 HEYL S1PR1	2.55e-04	193	71	4	194e7fa00a50cc4e026987b715323d125d79594e
ToppCell	RV-10._Endothelium_II\|World / Chamber and Cluster_Paper	CYP1B1 ARAP3 SYNE2 DAPK1	2.55e-04	193	71	4	2531266bc57339d4e2b22a88817008e32b8c1598
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BOC HEYL REM1 PODN	2.60e-04	194	71	4	7826fe5eb254ac032de0d978f39585a40e0b3ee4
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Mesenchymal-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC CYP1B1 REM1 PODN	2.60e-04	194	71	4	da926441053b499cb5107ccb116fb1b3844d82b7
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-3\|TCGA-Stomach / Sample_Type by Project: Shred V9	BOC CYP1B1 HEYL PODN	2.60e-04	194	71	4	2260cd817a6661e5eb6645b0c6786e18fd58371e
ToppCell	IPF-Stromal-Fibroblast\|Stromal / Disease state, Lineage and Cell class	SH3TC2 TIAM1 PODN LONRF2	2.60e-04	194	71	4	da3e1d39575969a069ef43e552afe94b2f441d0b
ToppCell	Endothelial-A-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	ARAP3 HEY1 DGKE S1PR1	2.60e-04	194	71	4	e656ac5539e59e321b46706cb8cc423b2c3358a0
ToppCell	Mesenchymal_cells-Arteriolar_fibro.\|World / Lineage and Cell class	BOC HMCN2 PODN AHNAK2	2.60e-04	194	71	4	c1e8923a50b4138a1e4c054c0c17b7f7122aa8a9
ToppCell	IPF-Endothelial-VE_Capillary_B\|IPF / Disease state, Lineage and Cell class	ARAP3 HEY1 F2RL3 S1PR1	2.60e-04	194	71	4	169a304d5c13f08c39fad4116f093bc4a0765e9d
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Mesenchymal\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC CYP1B1 REM1 PODN	2.60e-04	194	71	4	54a7f693966b5c02f6b248950ddb5fa32af3ae67
ToppCell	COPD-Endothelial-VE_Capillary_B\|COPD / Disease state, Lineage and Cell class	ARAP3 HEY1 F2RL3 S1PR1	2.60e-04	194	71	4	18b7f901c12ca4f21f9a1eafd092aefe4d668b6d
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC CYP1B1 REM1 PODN	2.60e-04	194	71	4	f34b3bbdebf56f66ff499e390e5515a4a4093f90
ToppCell	moderate-Epithelial-FOXN4+\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CCP110 AZU1 RECQL4 ASPM	2.60e-04	194	71	4	dff3fb10372053951d41e0ccd41aac3ece6009bd
ToppCell	COVID-19-kidney-PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	BOC ARAP3 F2RL3 S1PR1	2.65e-04	195	71	4	a436483fec137584611f86b7a498a4dc2aa19cd3
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD8+_T-MAIT\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ACP6 PDE7A SYNE2 LPCAT4	2.65e-04	195	71	4	c7b54b210cc2c8ddaefebfba74381adb2ca698b8
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD8+_T-MAIT-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ACP6 PDE7A SYNE2 LPCAT4	2.65e-04	195	71	4	a8fd42ff6c2bd80d0e3f20fe3bbf7d113b399df1
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARAP3 HEY1 DGKE S1PR1	2.70e-04	196	71	4	ae46d4b00be92e64e46252dcc156161b171eded4
ToppCell	COVID-19-lung-Capillary_Aerocytes\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ARAP3 F2RL3 SYNE2 S1PR1	2.70e-04	196	71	4	49cc0a2b9739abad61dff7292ea0b14d28ff35c4
ToppCell	Children_(3_yrs)-Mesenchymal\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BOC PTPRS GRIA1 PODN	2.70e-04	196	71	4	bc94909f9b2dc08a59eef1914148b69720569c8f
ToppCell	COVID-19-lung-Capillary_Aerocytes\|lung / Disease (COVID-19 only), tissue and cell type	ARAP3 F2RL3 SYNE2 S1PR1	2.70e-04	196	71	4	4ac4073380d939a73cec7413e9f3f5ef616d2924
ToppCell	ILEUM-inflamed-(7)_Endothelial_cell-(7)_CD36+_endothelial_cells\|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	HEY1 F2RL3 SYNE2 DGKE	2.75e-04	197	71	4	66339b5aae3952f5c484c9dcb0cfb4fbd828d4cb
Disease	Malignant neoplasm of breast	BOC CYP1B1 HEYL ARAP3 HEY1 SIPA1L1 SYNE2 NHS ZNF75A DGKE CUX1	2.80e-05	1074	67	11	C0006142
Disease	Neural crest tumor	MYCN HACE1	1.06e-04	7	67	2	C2931189
Disease	Neuroblastoma	MYCN DOCK8 HACE1	1.69e-04	47	67	3	C0027819
Disease	Colorectal Carcinoma	BOC CYP1B1 ARAP3 TIAM1 PTPRS LONRF2 CUX1 CABLES1	1.87e-04	702	67	8	C0009402
Disease	hematologic cancer (implicated_via_orthology)	TYK2 CUX1	3.90e-04	13	67	2	DOID:2531 (implicated_via_orthology)
Disease	MYELODYSPLASTIC SYNDROME	DAPK1 SLX4 CUX1	4.83e-04	67	67	3	C3463824
Disease	Leukemia, Myelocytic, Acute	DAPK1 SLX4 CUX1 MX1	6.56e-04	173	67	4	C0023467
Disease	nevus count	CYP1B1 DOCK8	7.59e-04	18	67	2	EFO_0004632
Disease	X-24309 measurement	ACP6 MIDEAS	9.40e-04	20	67	2	EFO_0800872
Disease	nevus count, cutaneous melanoma	CYP1B1 DOCK8 SYNE2	1.18e-03	91	67	3	EFO_0000389, EFO_0004632
Disease	Fanconi Anemia	SLX4 MX1	1.47e-03	25	67	2	C0015625
Disease	Adenoid Cystic Carcinoma	MYCN ASPM DAPK1	1.55e-03	100	67	3	C0010606
Disease	heart rate	ARAP3 SIPA1L1 RFX4 CUX1	1.73e-03	225	67	4	EFO_0004326
Disease	cardiovascular age measurement	SIPA1L1 ZC3H3	1.98e-03	29	67	2	EFO_0803380
Disease	Developmental Disabilities	SETD1A DOCK8	2.12e-03	30	67	2	C0008073
Disease	immature platelet fraction	DOCK8 CUX1 CABLES1	2.25e-03	114	67	3	EFO_0009187

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLRSFFRRRRPRLSS	DAPK1	711	P53355
LTGLRRRRRTFNRTA	GRAMD1C	506	Q8IYS0
ARARSLRLLAEFRRD	ARAP3	946	Q8WWN8
REQRSLRLSINARER	BHLHE23	96	Q8NDY6
TRFLSQLLERRRQAL	ARHGEF2	291	Q92974
RRQRLSHSRRAELQF	H2AL3	11	A0A3B3IU63
STRERLRERTRLNQS	SPECC1L	121	Q69YQ0
LRRQSRALLSALQRS	DNHD1	4406	Q96M86
RRRDLGSRLQAQRRA	DDRGK1	66	Q96HY6
QSSASRLLKRHRRRR	DVL2	226	O14641
RLNRLRRAACRLFTS	ASPM	761	Q8IZT6
ATLIQSRFRSLLVRR	ASPM	2411	Q8IZT6
SRFRSLLVRRRFISL	ASPM	2416	Q8IZT6
SRSLQDKRSARRLRR	ATG2A	1826	Q2TAZ0
ELSRRFSQILRRQTS	RFX4	311	Q33E94
RTNRTTFRNRRSLLL	PABIR3	51	Q6P4D5
QLRELYLTSNRLRSR	PODN	476	Q7Z5L7
RQRRRELSDRLNLSD	HOXC12	241	P31275
FSLQDALSRARERRL	MDC1	1981	Q14676
FLRIRVRGQRASRLQ	LPCAT4	106	Q643R3
RILERSLSRRSQAIA	HMCN2	61	Q8NDA2
RSRSTQQRSALLSRR	EZHIP	346	Q86X51
LLSIISSQRERFRAR	CUX1	501	Q13948
RNIRRLLSFQRYLRS	PDE7A	106	Q13946
EQLNRLTRSLRRART	HACE1	6	Q8IYU2
RDRINSSLSELRRLV	HEYL	56	Q9NQ87
RLRRLAGQARSLQRQ	LONRF2	196	Q1L5Z9
QDISRLQRRSLRHSR	PTPRS	1186	Q13332
LTLQRQTFRLARSDR	F2RL3	211	Q96RI0
SQRLRLSRRALRVLS	BOC	366	Q9BWV1
RRTLAQSRRLSERAL	DOCK8	436	Q8NF50
EQLQRSRRRLISQRS	CABLES1	276	Q8TDN4
ARALLERLQSRARER	DDX51	31	Q8N8A6
SRNRRALRDSRTRAL	FUT11	106	Q495W5
REQSRRSLRGSINRI	CCP110	241	O43303
RRRRASQEANLLTLA	MIDEAS	456	Q6PJG2
RRDRINNSLSELRRL	HEY1	61	Q9Y5J3
GQRLLRQRRRQLRSA	CYP1B1	36	Q16678
SATRRRRRQLQGLAA	ENGASE	11	Q8NFI3
SLQRSRRQLHRRDIF	DGKE	41	P52429
LEFRSIRGNLNTRLR	HMBS	161	P08397
SLRRQRIDISRRGNA	GRIA1	306	P42261
LRRRERQSRQTFSIS	AZU1	86	P20160
SLVRTRSRRLTFRKN	S1PR1	226	P21453
RLRRASETALQSSRR	LRRC72	16	A6NJI9
QRARRFLARLTARSA	REM1	266	O75628
FLARLTARSARRRAL	REM1	271	O75628
RRLRSLSLQANRVRA	NYX	206	Q9GZU5
FRRERSQMLLSRRNQ	NIPSNAP1	151	Q9BPW8
RRLARENRTDTASRL	SYNE2	6201	Q8WXH0
QDLSERERSLLRRRS	TMEM191B	91	P0C7N4
QDLSERERSLLRRRS	TMEM191C	91	A6NGB0
RQSLQALRREHRSRS	NHS	231	Q6T4R5
ARERQALARLRRTFQ	RECQL4	1061	O94761
RAQSRQRSLLRRRTS	PPP1R16A	326	Q96I34
ALRRIRQRSNSDITI	SIPA1L1	166	O43166
YRNLNTARSLRRSLT	SH3TC2	1011	Q8TF17
RVLSERRSEQRRLLS	SETD1A	1531	O15047
RAQLERARLLARFRT	SPTBN5	1936	Q9NRC6
LQLRRRLREFRGNSA	SPTBN5	2291	Q9NRC6
RQNGLRVSSRRLLDF	SLX4	1786	Q8IY92
GSQRRRKFLNLRFRT	AHNAK2	316	Q8IVF2
LSARLRALRQRQLDR	SELENOS	51	Q9BQE4
MDSSRARQQLRRRFL	TMEM128	1	Q5BJH2
RRLSLSRSLVLNRLR	ZC3H3	566	Q8IXZ2
RRRRLARNRFTIDSD	TIAM1	1446	Q13009
RQRRNDLRSSFLTLR	MYCN	391	P04198
RLSFTLERLSSRLQR	SPEG	2456	Q15772
LRQRTRGRRQTASLQ	ACP6	211	Q9NPH0
RSFLCRSRLQRDIRR	UBE3B	41	Q7Z3V4
RRRRNLRSFTERNAD	TRPC5	691	Q9UL62
RSRVRTLRQAFLALQ	TCF23	86	Q7RTU1
SICRRNFSRRSSLLR	ZNF75A	276	Q96N20
HSALTRLRLRNVFRR	TYK2	226	P29597
RLARLTQARRRLAQF	MX1	646	P20591