Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	actin filament binding	NRAP SYNE1 SPTAN1 PLEC MYO18B NEB IQGAP3	1.09e-05	227	67	7	GO:0051015
GeneOntologyMolecularFunction	cytoskeletal protein binding	APPBP2 NRAP ALMS1 SMC3 SYNE1 SPTAN1 NCKIPSD GNAS PLEC MYO18B NEB IQGAP3 EML3 KPNB1	1.36e-05	1099	67	14	GO:0008092
GeneOntologyMolecularFunction	group III metabotropic glutamate receptor activity	GRM4 GRM6	6.63e-05	4	67	2	GO:0001642
GeneOntologyMolecularFunction	G protein-coupled glutamate receptor activity	GRM4 GRM6	3.93e-04	9	67	2	GO:0098988
GeneOntologyMolecularFunction	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	GRM4 GRM6	3.93e-04	9	67	2	GO:0001640
GeneOntologyMolecularFunction	cytoskeletal motor activity	APPBP2 SMC3 MYO18B DYNC1H1	6.67e-04	118	67	4	GO:0003774
GeneOntologyMolecularFunction	actin binding	NRAP SYNE1 SPTAN1 PLEC MYO18B NEB IQGAP3	1.10e-03	479	67	7	GO:0003779
GeneOntologyBiologicalProcess	organelle assembly	NRAP ALMS1 TCHP SMC3 CFAP97D1 SYNE1 PLEC NEB BBS9 EML3 DYNC1H1 VPS13B IQUB DHX30 KPNB1	2.81e-06	1138	67	15	GO:0070925
GeneOntologyBiologicalProcess	ultradian rhythm	ENOX1 ENOX2	1.04e-05	2	67	2	GO:0007624
GeneOntologyBiologicalProcess	membraneless organelle assembly	NRAP ALMS1 SMC3 PLEC NEB EML3 DYNC1H1 DHX30 KPNB1	2.21e-05	475	67	9	GO:0140694
GeneOntologyBiologicalProcess	cardiac muscle thin filament assembly	NRAP NEB	3.11e-05	3	67	2	GO:0071691
GeneOntologyBiologicalProcess	actomyosin contractile ring assembly actin filament organization	PLEC IQGAP3	6.21e-05	4	67	2	GO:2000689
GeneOntologyBiologicalProcess	actomyosin structure organization	NRAP ALMS1 PLEC MYO18B NEB IQGAP3	1.26e-04	239	67	6	GO:0031032
GeneOntologyBiologicalProcess	cellular anatomical entity morphogenesis	NRAP MIOS PLEC NEB VPS13B	1.54e-04	156	67	5	GO:0032989
GeneOntologyBiologicalProcess	cellular component assembly involved in morphogenesis	NRAP MIOS PLEC NEB VPS13B	1.54e-04	156	67	5	GO:0010927
GeneOntologyCellularComponent	sarcomere	NRAP SYNE1 SPTAN1 STYXL2 PLEC MYO18B NEB	1.48e-05	249	67	7	GO:0030017
GeneOntologyCellularComponent	myofibril	NRAP SYNE1 SPTAN1 STYXL2 PLEC MYO18B NEB	2.67e-05	273	67	7	GO:0030016
GeneOntologyCellularComponent	contractile muscle fiber	NRAP SYNE1 SPTAN1 STYXL2 PLEC MYO18B NEB	3.93e-05	290	67	7	GO:0043292
GeneOntologyCellularComponent	Z disc	NRAP SPTAN1 PLEC MYO18B NEB	1.24e-04	151	67	5	GO:0030018
GeneOntologyCellularComponent	muscle tendon junction	NRAP HMCN1	1.51e-04	6	67	2	GO:0005927
GeneOntologyCellularComponent	I band	NRAP SPTAN1 PLEC MYO18B NEB	1.93e-04	166	67	5	GO:0031674
GeneOntologyCellularComponent	supramolecular fiber	APPBP2 NRAP TCHP SYNE1 SPTAN1 NCKIPSD STYXL2 PLEC MYO18B NEB EML3 DYNC1H1	3.29e-04	1179	67	12	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	APPBP2 NRAP TCHP SYNE1 SPTAN1 NCKIPSD STYXL2 PLEC MYO18B NEB EML3 DYNC1H1	3.50e-04	1187	67	12	GO:0099081
GeneOntologyCellularComponent	fascia adherens	NRAP SPTAN1	7.72e-04	13	67	2	GO:0005916
GeneOntologyCellularComponent	cell cortex	ITCH HMCN1 TCHP SPTAN1 IQGAP3 DYNC1H1	1.20e-03	371	67	6	GO:0005938
HumanPheno	Abnormal palm morphology	KMT2D ITCH SMC3 OTUD5 MMP1 PLEC SMC5 BCR DYNC1H1 VPS13B DHX30	8.33e-06	521	24	11	HP:0100871
HumanPheno	Hyperostosis frontalis interna	ALMS1 GNAS	2.13e-05	2	24	2	HP:0004438
HumanPheno	Truncal obesity	ALMS1 SMC3 GNAS BBS9 VPS13B	3.20e-05	82	24	5	HP:0001956
HumanPheno	Motor delay	KMT2D ITCH ALMS1 SMC3 SYNE1 SPTAN1 NBEA PLEC MYO18B NEB SMC5 DYNC1H1 VPS13B DHX30	3.88e-05	1018	24	14	HP:0001270
HumanPheno	Hirsutism	FRMD4A KMT2D ALMS1 SMC3 OTUD5 GNAS BBS9	4.18e-05	216	24	7	HP:0001007
HumanPheno	Abnormal skin morphology of the palm	KMT2D ITCH SMC3 OTUD5 MMP1 PLEC SMC5 VPS13B DHX30	6.03e-05	413	24	9	HP:0040211
HumanPheno	Bilateral facial palsy	SYNE1 PLEC	6.36e-05	3	24	2	HP:0430025
HumanPheno	Abnormality of the palmar creases	KMT2D ITCH SMC3 OTUD5 SMC5 VPS13B DHX30	1.36e-04	260	24	7	HP:0010490
HumanPheno	Abnormal pinna morphology	FRMD4A KMT2D ITCH ALMS1 SMC3 OTUD5 SYNE1 PLEC MYO18B NEB SMC5 BCR BBS9 VPS13B DHX30	1.37e-04	1299	24	15	HP:0000377
HumanPheno	Abnormal palmar dermatoglyphics	KMT2D ITCH SMC3 OTUD5 SMC5 VPS13B DHX30	1.53e-04	265	24	7	HP:0001018
HumanPheno	Thoracic scoliosis	KMT2D ITCH ALMS1 VPS13B	1.55e-04	60	24	4	HP:0002943
HumanPheno	Abnormality of the outer ear	FRMD4A KMT2D ITCH ALMS1 SMC3 OTUD5 SYNE1 PLEC MYO18B NEB SMC5 BCR BBS9 VPS13B DHX30	1.95e-04	1337	24	15	HP:0000356
HumanPheno	Abnormal joint physiology	KMT2D ITCH SMC3 OTUD5 SYNE1 SPTAN1 MMP1 GNAS PLEC MYO18B NEB BCR BBS9 VPS13B DHX30	2.36e-04	1358	24	15	HP:0034430
HumanPheno	Abnormality of joint mobility	KMT2D ITCH SMC3 OTUD5 SYNE1 SPTAN1 MMP1 GNAS PLEC MYO18B NEB BCR BBS9 VPS13B DHX30	2.36e-04	1358	24	15	HP:0011729
HumanPheno	Ankyloglossia	KMT2D MMP1 BCR	3.10e-04	29	24	3	HP:0010296
HumanPheno	Upper eyelid edema	FRMD4A DHX30	3.15e-04	6	24	2	HP:0012724
HumanPheno	Elevated circulating thyroid-stimulating hormone concentration	ALMS1 GNAS SMC5	3.43e-04	30	24	3	HP:0002925
HumanPheno	Single transverse palmar crease	KMT2D ITCH SMC3 SMC5 VPS13B DHX30	3.74e-04	215	24	6	HP:0000954
HumanPheno	Abnormal dermatoglyphics	KMT2D ITCH SMC3 OTUD5 SMC5 VPS13B DHX30	4.39e-04	314	24	7	HP:0007477
HumanPheno	Decreased cervical spine flexion due to contractures of posterior cervical muscles	SYNE1 PLEC	4.40e-04	7	24	2	HP:0004631
HumanPheno	Facial hyperostosis	ALMS1 GNAS	4.40e-04	7	24	2	HP:0005465
HumanPheno	Hyperlordosis	ITCH SYNE1 PLEC NEB BCR VPS13B	4.45e-04	222	24	6	HP:0003307
HumanPheno	Lordosis	ITCH SYNE1 PLEC NEB BCR VPS13B	4.45e-04	222	24	6	HP:0002939
HumanPheno	Regional abnormality of skin	KMT2D ITCH SMC3 OTUD5 MMP1 PLEC SMC5 VPS13B DHX30	4.85e-04	541	24	9	HP:0011356
HumanPheno	Obesity	SEMA3A KMT2D ALMS1 SMC3 SYNE1 GNAS BBS9 VPS13B	4.88e-04	425	24	8	HP:0001513
HumanPheno	Hypertrichosis	FRMD4A KMT2D ALMS1 SMC3 OTUD5 GNAS BBS9 DHX30	4.88e-04	425	24	8	HP:0000998
HumanPheno	Abnormal hair pattern	FRMD4A KMT2D ALMS1 SMC3 OTUD5 GNAS MYO18B BBS9 VPS13B DHX30	5.38e-04	676	24	10	HP:0010720
HumanPheno	Nasolacrimal duct obstruction	KMT2D SMC3 SMC5	5.93e-04	36	24	3	HP:0000579
Domain	KRAB	ZNF773 ZNF544 ZNF559 ZNF846 ZNF92 ZNF727 ZNF736 ZIM3	2.93e-05	358	64	8	PS50805
Domain	KRAB	ZNF773 ZNF544 ZNF559 ZNF846 ZNF92 ZNF727 ZNF736 ZIM3	2.93e-05	358	64	8	PF01352
Domain	KRAB	ZNF773 ZNF544 ZNF559 ZNF846 ZNF92 ZNF727 ZNF736 ZIM3	3.63e-05	369	64	8	SM00349
Domain	KRAB	ZNF773 ZNF544 ZNF559 ZNF846 ZNF92 ZNF727 ZNF736 ZIM3	3.70e-05	370	64	8	IPR001909
Domain	NEBU	NRAP NEB	6.90e-05	4	64	2	SM00227
Domain	Nebulin	NRAP NEB	6.90e-05	4	64	2	PF00880
Domain	Nebulin	NRAP NEB	6.90e-05	4	64	2	IPR013998
Domain	NEBULIN	NRAP NEB	6.90e-05	4	64	2	PS51216
Domain	Nebulin_repeat	NRAP NEB	6.90e-05	4	64	2	IPR000900
Domain	Spectrin_repeat	SYNE1 SPTAN1 PLEC	1.32e-04	29	64	3	IPR002017
Domain	Spectrin/alpha-actinin	SYNE1 SPTAN1 PLEC	1.77e-04	32	64	3	IPR018159
Domain	SPEC	SYNE1 SPTAN1 PLEC	1.77e-04	32	64	3	SM00150
Domain	IQ	LRRIQ3 MYO18B IQGAP3 IQUB	2.91e-04	93	64	4	PS50096
Domain	RecF/RecN/SMC_N	SMC3 SMC5	3.19e-04	8	64	2	IPR003395
Domain	SMC_N	SMC3 SMC5	3.19e-04	8	64	2	PF02463
Domain	GPCR_3_mtglu_rcpt	GRM4 GRM6	3.19e-04	8	64	2	IPR000162
Domain	zf-C2H2_6	ZNF773 ZNF846 ZNF92 ZNF727 ZNF736 ZIM3	7.12e-04	314	64	6	PF13912
Domain	NCD3G	GRM4 GRM6	8.80e-04	13	64	2	PF07562
Domain	GPCR_3_9-Cys_dom	GRM4 GRM6	8.80e-04	13	64	2	IPR011500
Domain	IMPORTIN_B_NT	XPO6 KPNB1	1.02e-03	14	64	2	PS50166
Domain	GPCR_3_CS	GRM4 GRM6	1.02e-03	14	64	2	IPR017979
Domain	IBN_N	XPO6 KPNB1	1.18e-03	15	64	2	PF03810
Domain	Post-SET_dom	SETMAR KMT2D	1.34e-03	16	64	2	IPR003616
Domain	PostSET	SETMAR KMT2D	1.34e-03	16	64	2	SM00508
Domain	IBN_N	XPO6 KPNB1	1.34e-03	16	64	2	SM00913
Domain	POST_SET	SETMAR KMT2D	1.34e-03	16	64	2	PS50868
Domain	CH	SYNE1 PLEC IQGAP3	1.44e-03	65	64	3	SM00033
Domain	Importin-beta_N	XPO6 KPNB1	1.52e-03	17	64	2	IPR001494
Domain	Pept_M10A_stromelysin-type	MMP28 MMP1	1.71e-03	18	64	2	IPR016293
Domain	CH	SYNE1 PLEC IQGAP3	1.78e-03	70	64	3	PF00307
Domain	-	SYNE1 PLEC IQGAP3	1.86e-03	71	64	3	1.10.418.10
Domain	CH	SYNE1 PLEC IQGAP3	2.01e-03	73	64	3	PS50021
Domain	PG_binding_1	MMP28 MMP1	2.11e-03	20	64	2	PF01471
Domain	Peptidoglycan-bd-like	MMP28 MMP1	2.11e-03	20	64	2	IPR002477
Domain	-	ZNF773 ZNF544 ZNF559 ZNF846 ZNF92 ZNF727 ZNF736 ZIM3	2.15e-03	679	64	8	3.30.160.60
Domain	CH-domain	SYNE1 PLEC IQGAP3	2.17e-03	75	64	3	IPR001715
Domain	GPCR_3	GRM4 GRM6	2.33e-03	21	64	2	IPR000337
Domain	SH3_1	SPTAN1 NCKIPSD PLCG1 NEB	2.42e-03	164	64	4	PF00018
Domain	zf-C2H2	ZNF773 ZNF544 ZNF559 ZNF846 ZNF92 ZNF727 ZNF736 ZIM3	2.44e-03	693	64	8	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF773 ZNF544 ZNF559 ZNF846 ZNF92 ZNF727 ZNF736 ZIM3	2.46e-03	694	64	8	IPR013087
Domain	7tm_3	GRM4 GRM6	2.55e-03	22	64	2	PF00003
Domain	G_PROTEIN_RECEP_F3_2	GRM4 GRM6	2.55e-03	22	64	2	PS00980
Domain	G_PROTEIN_RECEP_F3_3	GRM4 GRM6	2.55e-03	22	64	2	PS00981
Domain	G_PROTEIN_RECEP_F3_1	GRM4 GRM6	2.55e-03	22	64	2	PS00979
Domain	G_PROTEIN_RECEP_F3_4	GRM4 GRM6	2.55e-03	22	64	2	PS50259
Domain	GPCR_3_C	GRM4 GRM6	2.55e-03	22	64	2	IPR017978
Domain	IQ	LRRIQ3 MYO18B IQGAP3	2.71e-03	81	64	3	SM00015
Domain	Actinin_actin-bd_CS	SYNE1 PLEC	2.79e-03	23	64	2	IPR001589
Domain	Hemopexin-like_dom	MMP28 MMP1	2.79e-03	23	64	2	IPR000585
Domain	Hemopexin-like_repeat	MMP28 MMP1	2.79e-03	23	64	2	IPR018487
Domain	Spectrin	SYNE1 SPTAN1	2.79e-03	23	64	2	PF00435
Domain	M10A_MMP	MMP28 MMP1	2.79e-03	23	64	2	IPR033739
Domain	Hemopexin	MMP28 MMP1	2.79e-03	23	64	2	PF00045
Domain	HEMOPEXIN	MMP28 MMP1	2.79e-03	23	64	2	PS00024
Domain	ACTININ_2	SYNE1 PLEC	2.79e-03	23	64	2	PS00020
Domain	-	MMP28 MMP1	2.79e-03	23	64	2	2.110.10.10
Domain	HEMOPEXIN_2	MMP28 MMP1	2.79e-03	23	64	2	PS51642
Domain	ACTININ_1	SYNE1 PLEC	2.79e-03	23	64	2	PS00019
Domain	HX	MMP28 MMP1	2.79e-03	23	64	2	SM00120
Domain	Pept_M10A	MMP28 MMP1	2.79e-03	23	64	2	IPR021190
Domain	Peptidase_M10	MMP28 MMP1	3.04e-03	24	64	2	PF00413
Domain	IQ_motif_EF-hand-BS	LRRIQ3 MYO18B IQGAP3	3.65e-03	90	64	3	IPR000048
Domain	ZnMc	MMP28 MMP1	4.42e-03	29	64	2	SM00235
Domain	Peptidase_Metallo	MMP28 MMP1	4.42e-03	29	64	2	IPR006026
Domain	ZINC_PROTEASE	TRHDE MMP28 MMP1	4.63e-03	98	64	3	PS00142
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	ALMS1 ZNF544 SYNE1 ZNF92 SPTAN1 PLCG1 DYNC1H1 KPNB1	9.86e-11	120	68	8	31413325
Pubmed	NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.	TRHDE ZNF717 SYNE1 SPTAN1 PLEC BCR DYNC1H1 DHX30 KPNB1	1.82e-08	333	68	9	32665550
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	RCOR1 TCHP SMC3 XPO6 CD2BP2 MIOS STYXL2 PLEC BCR BBS9 IQGAP3 DYNC1H1 DHX30 KPNB1 SRSF12	3.05e-08	1321	68	15	27173435
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	ITCH ENOX1 OTUD5 TNIP2 SPTAN1 NIPSNAP2 GNAS IQGAP3 ABHD17C DHX30 KPNB1 ENOX2	2.09e-07	922	68	12	27609421
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	FRMD4A SMC3 SYNE1 SPTAN1 NBEA DYNC1H1	5.31e-07	151	68	6	17043677
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	ITCH NRAP ALMS1 SYNE1 NIPSNAP2 PLEC MYO18B NEB KPNB1	5.40e-07	497	68	9	23414517
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	RCOR1 SMC3 SYNE1 CD2BP2 GNAS SMC5 IQGAP3 EML3 DYNC1H1 VPS13B DHX30 KPNB1	2.23e-06	1155	68	12	20360068
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	SPTAN1 PLCG1 PLEC HNRNPLL DYNC1H1 PLD4 KPNB1	5.03e-06	344	68	7	30333137
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SETMAR ITCH SYNE1 ZNF92 SPTAN1 CUL9 NBEA PLCG1 PLEC DYNC1H1 DHX30 KPNB1	6.61e-06	1285	68	12	35914814
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	KMT2D SYNE1 PLEC NEB VPS13B DHX30	6.72e-06	234	68	6	36243803
Pubmed	Identification of novel spartin-interactors shows spartin is a multifunctional protein.	ITCH DYNC1H1 KPNB1	6.77e-06	19	68	3	19765186
Pubmed	DDX39B facilitates the malignant progression of hepatocellular carcinoma via activation of SREBP1-mediated de novo lipid synthesis.	SPTAN1 PLEC DHX30 KPNB1	7.30e-06	63	68	4	37052853
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KMT2D XPO6 CD2BP2 CUL9 PLCG1 PLEC BCR IQGAP3 EML3 DYNC1H1 DHX30	9.26e-06	1105	68	11	35748872
Pubmed	Nuclear import and subnuclear localization of the proto-oncoprotein ETO (MTG8).	RUNX1T1 KPNB1	1.13e-05	3	68	2	10951564
Pubmed	The E3 ubiquitin ligase Itch regulates tumor suppressor protein RASSF5/NORE1 stability in an acetylation-dependent manner.	ITCH KPNB1	1.13e-05	3	68	2	23538446
Pubmed	Homologs of Drosophila Fushi-Tarazu factor 1 map to mouse chromosome 2 and human chromosome 9q33.	SPTAN1 NEB	1.13e-05	3	68	2	7789992
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	HMCN1 SYNE1 PLEC RUNX1T1 NEB	1.25e-05	152	68	5	34299191
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	APPBP2 SYNE1 CUL9 SMC5 DYNC1H1 VPS13B DHX30	1.50e-05	407	68	7	12693553
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	RCOR1 ITCH SYNE1 SPTAN1 MIOS NBEA GRM4 BCR DYNC1H1 KPNB1	1.72e-05	963	68	10	28671696
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	SMC3 XPO6 SPTAN1 GNAS PLEC HNRNPLL DYNC1H1 KPNB1	1.79e-05	582	68	8	20467437
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	ALMS1 TCHP OTUD5 ZNF92 CD2BP2 CUL9 GNAS BCR	1.93e-05	588	68	8	38580884
Pubmed	Nucleolin-Mediated RNA Localization Regulates Neuron Growth and Cycling Cell Size.	DYNC1H1 KPNB1	2.25e-05	4	68	2	27477284
Pubmed	TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade.	GNAS GRM6	2.25e-05	4	68	2	19966281
Pubmed	Distribution of group-III metabotropic glutamate receptors in the retina.	GRM4 GRM6	2.25e-05	4	68	2	17311335
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FRMD4A RCOR1 XPO6 NBEA	2.63e-05	87	68	4	12465718
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	ITCH MIOS CUL9 GNAS BCR DHX30	3.47e-05	313	68	6	38270169
Pubmed	Plectin and IFAP-300K are homologous proteins binding to microtubule-associated proteins 1 and 2 and to the 240-kilodalton subunit of spectrin.	SPTAN1 PLEC	3.75e-05	5	68	2	3027087
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	SMC3 SPTAN1 PLEC HNRNPLL EML3 DYNC1H1	4.81e-05	332	68	6	32786267
Pubmed	Pias1 interaction and sumoylation of metabotropic glutamate receptor 8.	GRM4 GRM6	5.62e-05	6	68	2	16144832
Pubmed	Cutting edge: integration of human T lymphocyte cytoskeleton by the cytolinker plectin.	SPTAN1 PLEC	5.62e-05	6	68	2	11441066
Pubmed	TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.	SYNE1 PLEC	5.62e-05	6	68	2	18827015
Pubmed	Dysregulation of NRAP degradation by KLHL41 contributes to pathophysiology in nemaline myopathy.	NRAP NEB	5.62e-05	6	68	2	30986853
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	ZNF559 SYNE1 CUL9 PLEC NEB	6.40e-05	214	68	5	22199357
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	ITCH SPTAN1 CD2BP2 PLEC SMC5 DYNC1H1	7.52e-05	360	68	6	33111431
Pubmed	Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion.	GRM4 GRM6	7.86e-05	7	68	2	9920659
Pubmed	A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction.	PLCG1 BCR	7.86e-05	7	68	2	1383690
Pubmed	The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells.	DYNC1H1 KPNB1	7.86e-05	7	68	2	26195665
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	ALMS1 XPO6 SYNE1 SMC5 NDRG4	8.11e-05	225	68	5	12168954
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	RCOR1 CD2BP2 PLEC HNRNPLL DYNC1H1 DHX30	8.74e-05	370	68	6	22922362
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	SMC3 SYNE1 SPTAN1 PLCG1 GNAS MYO18B HNRNPLL IQGAP3 DYNC1H1 DHX30 KPNB1	9.41e-05	1425	68	11	30948266
Pubmed	Human transcription factor protein interaction networks.	RCOR1 KMT2D ALMS1 MRS2 SMC3 TNIP2 SPTAN1 CD2BP2 CUL9 DYNC1H1 DHX30	9.65e-05	1429	68	11	35140242
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	SYNE1 SPTAN1 NCKIPSD MIOS NIPSNAP2 NBEA PLEC BCR DYNC1H1 DHX30 KPNB1	9.77e-05	1431	68	11	37142655
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	ALMS1 XPO6 SPTAN1 GNAS HNRNPLL	1.14e-04	242	68	5	34011540
Pubmed	The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling.	PLCG1 BCR	1.34e-04	9	68	2	8995379
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	ITCH SMC3 SPTAN1 CD2BP2 GNAS PLEC IQGAP3 DYNC1H1 DHX30 KPNB1	1.59e-04	1257	68	10	36526897
Pubmed	Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl.	SMC3 SMC5	1.68e-04	10	68	2	22751501
Pubmed	Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.	GRM4 GRM6	1.68e-04	10	68	2	9069281
Pubmed	K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.	RCOR1 KMT2D ITCH OTUD5 TNIP2 NIPSNAP2 IQGAP3	1.78e-04	604	68	7	38803224
Pubmed	Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.	TRHDE LRRIQ3 ALMS1	1.84e-04	56	68	3	23934736
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	SMC3 SPTAN1 CD2BP2 PLEC DYNC1H1	1.97e-04	272	68	5	31010829
Pubmed	Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.	SPTAN1 PLEC BCR DYNC1H1	2.02e-04	147	68	4	16959763
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	SMC3 SPTAN1 PLEC DHX30 KPNB1	2.03e-04	274	68	5	34244482
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	SYNE1 SPTAN1 NBEA GNAS DYNC1H1	2.29e-04	281	68	5	28706196
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	ALMS1 TCHP SMC3 SPTAN1 NCKIPSD NIPSNAP2	2.41e-04	446	68	6	24255178
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	SYNE1 SPTAN1 CD2BP2 MIOS PLEC HNRNPLL DYNC1H1 DHX30 KPNB1	2.51e-04	1082	68	9	38697112
Pubmed	Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.	SPTAN1 BCR DHX30 KPNB1	2.54e-04	156	68	4	22952844
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	APPBP2 MRS2 OTUD5 SPTAN1 NIPSNAP2 PLEC	3.60e-04	481	68	6	28190767
Pubmed	Interspecific backcross mice show sex-specific differences in allelic inheritance.	SPTAN1 NEB	3.89e-04	15	68	2	1916246
Pubmed	The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.	KMT2D SMC3	3.89e-04	15	68	2	17925232
Pubmed	The protein interaction landscape of the human CMGC kinase group.	ALMS1 TNIP2 SPTAN1 NEB KPNB1 SRSF12 ENOX2	4.16e-04	695	68	7	23602568
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	SMC3 GNAS NEB DYNC1H1 KPNB1	4.27e-04	322	68	5	26514267
Pubmed	Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.	ITCH SMC3 PLCG1 GNAS KPNB1	4.33e-04	323	68	5	24797263
Pubmed	KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy.	NRAP NEB	4.44e-04	16	68	2	24960163
Pubmed	Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins.	SPTAN1 PLEC	4.44e-04	16	68	2	16944923
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	NCKIPSD CUL9 NBEA PLCG1 MYO18B	4.70e-04	329	68	5	17474147
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	SPTAN1 PLEC DYNC1H1 PLD4 KPNB1	4.90e-04	332	68	5	37433992
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	ALMS1 SYNE1 SPTAN1 PLEC	5.04e-04	187	68	4	26460568
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	SMC3 SYNE1 SPTAN1 GNAS PLEC DYNC1H1 DHX30 KPNB1	5.19e-04	949	68	8	36574265
Pubmed	TRIM24 is an insulin-responsive regulator of P-bodies.	SMC3 SPTAN1 DHX30	5.27e-04	80	68	3	35803934
Pubmed	Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability.	ITCH SPTAN1 PLEC DYNC1H1	5.46e-04	191	68	4	33762435
Pubmed	The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization.	NCKIPSD PLEC BCR	5.47e-04	81	68	3	20697350
Pubmed	The nuclear import of the small GTPase Rac1 is mediated by the direct interaction with karyopherin alpha2.	IQGAP3 KPNB1	5.65e-04	18	68	2	19961560
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	RCOR1 KMT2D SMC3	5.87e-04	83	68	3	28794006
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	SMC3 SYNE1 SPTAN1 KPNB1	6.13e-04	197	68	4	20811636
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	SMC3 SPTAN1 MYO18B DYNC1H1 DHX30 KPNB1	6.48e-04	538	68	6	28524877
Pubmed	Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip.	ALMS1 GRM6 BBS9	6.74e-04	87	68	3	20801516
Pubmed	MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination.	NRAP NEB	7.00e-04	20	68	2	15967462
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	RCOR1 ITCH SMC3 SPTAN1 GNAS HNRNPLL DYNC1H1 DHX30 KPNB1	7.00e-04	1247	68	9	27684187
Pubmed	USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c.	TCHP PLEC DYNC1H1	7.44e-04	90	68	3	35654790
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	ITCH SMC3 OTUD5 CD2BP2 MIOS NIPSNAP2 PLEC BCR	7.54e-04	1005	68	8	19615732
Pubmed	ARRDC1 and ARRDC3 act as tumor suppressors in renal cell carcinoma by facilitating YAP1 degradation.	ITCH KPNB1	7.72e-04	21	68	2	29416926
Pubmed	Quantitative analysis of PPT1 interactome in human neuroblastoma cells.	SPTAN1 PLEC DYNC1H1 KPNB1	7.78e-04	210	68	4	26217791
Pubmed	Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.	BCR IQGAP3 DYNC1H1 KPNB1	7.91e-04	211	68	4	17314511
Pubmed	Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.	PLCG1 MMP1 GNAS RUNX1T1 BCR	8.08e-04	371	68	5	25241761
Pubmed	Functional interactions between matrix metalloproteinases and glycosaminoglycans.	MMP28 MMP1	8.48e-04	22	68	2	23421805
Pubmed	The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart.	SEMA3A MYO18B	8.48e-04	22	68	2	36877136
Pubmed	HEY1 functions are regulated by its phosphorylation at Ser-68.	SYNE1 PLEC HNRNPLL	8.70e-04	95	68	3	27129302
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	FRMD4A APPBP2 MRS2 ZNF559 ZNF92 SPTAN1 PLEC NEB SRSF12	9.05e-04	1293	68	9	15342556
Pubmed	Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.	SMC3 SPTAN1 PLEC HNRNPLL	9.09e-04	219	68	4	31353912
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	SYNE1 SPTAN1 GNAS PLEC IQGAP3 DYNC1H1 KPNB1	1.00e-03	807	68	7	30575818
Pubmed	Glutamate can act as a signaling molecule in mouse preimplantation embryos†.	GRM4 GRM6	1.01e-03	24	68	2	35746896
Pubmed	A proteomics approach for the identification of cullin-9 (CUL9) related signaling pathways in induced pluripotent stem cell models.	CUL9 DYNC1H1	1.01e-03	24	68	2	33705438
Pubmed	Functional proteomics mapping of a human signaling pathway.	KMT2D CCDC127 PLEC DYNC1H1 DHX30 KPNB1	1.05e-03	591	68	6	15231748
Pubmed	An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.	SMC3 SPTAN1 PLEC DYNC1H1 KPNB1	1.09e-03	397	68	5	21319273
Pubmed	NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy.	SPTAN1 PLEC	1.10e-03	25	68	2	30309841
Pubmed	Holoprosencephaly Overview	KMT2D SMC3	1.10e-03	25	68	2	20301702
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	ALMS1 XPO6 DYNC1H1	1.13e-03	104	68	3	9205841
Pubmed	Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.	NIPSNAP2 EML3	1.19e-03	26	68	2	24067654
Pubmed	The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.	SMC3 PLCG1 SMC5 DYNC1H1	1.22e-03	237	68	4	29564676
Pubmed	Histone methylation mediated by NSD1 is required for the establishment and maintenance of neuronal identities.	NRAP MYO18B	1.28e-03	27	68	2	37995181
Interaction	MECOM interactions	APPBP2 RCOR1 SMC3 TNIP2 PLEC NEB IQGAP3 DYNC1H1 KPNB1	3.12e-06	358	68	9	int:MECOM
Interaction	NUDCD2 interactions	TRHDE ZNF717 SYNE1 SPTAN1 PLEC BCR DYNC1H1 DHX30 KPNB1	1.22e-05	424	68	9	int:NUDCD2
Interaction	DISC1 interactions	SEMA3A ITCH ALMS1 SMC3 SYNE1 SPTAN1 PLCG1 SMC5 DYNC1H1	1.34e-05	429	68	9	int:DISC1
Interaction	MYO18B interactions	CUL9 PLEC MYO18B	1.62e-05	15	68	3	int:MYO18B
Interaction	ENOX1 interactions	ENOX1 TNIP2 ENOX2	4.02e-05	20	68	3	int:ENOX1
Interaction	DYNLL1 interactions	RCOR1 TNIP2 NCKIPSD PLCG1 SMC5 BCR EML3 DYNC1H1 IQUB	5.19e-05	510	68	9	int:DYNLL1
Interaction	SUZ12 interactions	RCOR1 KMT2D ALMS1 SMC3 SYNE1 PLEC SMC5 DYNC1H1 DHX30 KPNB1	5.66e-05	644	68	10	int:SUZ12
Interaction	ACTB interactions	RCOR1 NRAP ALMS1 TCHP SMC3 XPO6 TNIP2 SPTAN1 PLEC MYO18B NEB SMC5 DYNC1H1	5.76e-05	1083	68	13	int:ACTB
Interaction	GFI1 interactions	RCOR1 TNIP2 RUNX1T1	7.07e-05	24	68	3	int:GFI1
Interaction	AGAP2 interactions	SYNE1 SPTAN1 NBEA PLCG1 GNAS DYNC1H1	7.62e-05	210	68	6	int:AGAP2
Interaction	CDCA5 interactions	SMC3 SPTAN1 CD2BP2 CUL9 SMC5	1.10e-04	140	68	5	int:CDCA5
Interaction	RABL2A interactions	ALMS1 SPTAN1 SMC5	1.13e-04	28	68	3	int:RABL2A
Cytoband	7q11.21	ZNF92 ZNF727 ZNF736	2.62e-04	83	68	3	7q11.21
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF717 ZNF773 ZNF544 ZNF559 ZNF846 ZNF92 ZNF727 ZNF736 ZIM3	9.75e-05	718	48	9	28
GeneFamily	Structural maintenance of chromosomes proteins\|Cohesin complex	SMC3 SMC5	1.44e-04	7	48	2	761
GeneFamily	Glutamate metabotropic receptors\|Protein phosphatase 1 regulatory subunits	GRM4 GRM6	1.91e-04	8	48	2	281
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP28 MMP1	1.84e-03	24	48	2	891
GeneFamily	RNA binding motif containing	ENOX1 HNRNPLL SRSF12 ENOX2	2.43e-03	213	48	4	725
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ITCH BCR	4.10e-03	36	48	2	823
GeneFamily	Phospholipases	PLCG1 PLD4	5.55e-03	42	48	2	467
Coexpression	PARENT_MTOR_SIGNALING_UP	SEMA3A XPO6 SYNE1 NCKIPSD CUL9 PLCG1 GNAS EML3 DHX30	1.54e-05	567	68	9	M16909
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	KMT2D SMC3 OTUD5 XPO6 SYNE1 SPTAN1 PLCG1 GNAS SMC5 HNRNPLL EML3 DYNC1H1 VPS13B KPNB1	2.40e-05	1492	68	14	M40023
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FRMD4A SYNE1 SPTAN1 NBEA GNAS NDRG4	5.87e-07	198	68	6	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	facs-Lung-nan-3m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRMD4A NRAP MMP28 BCR NDRG4	6.24e-06	170	68	5	67d7e1da3ebd2d14cb2e67799e94d655027ed5c4
ToppCell	facs-Lung-nan-3m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRMD4A NRAP MMP28 BCR NDRG4	6.24e-06	170	68	5	8e1f757ed62218c0fb6525f49d142dd2cd29acf9
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TRHDE FRMD4A ENOX1 HMCN1 RUNX1T1	1.18e-05	194	68	5	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SYNE1 MUC16 ECT2L NBEA IQUB	1.18e-05	194	68	5	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TRHDE HMCN1 ZNF559 SYNE1 RUNX1T1	1.27e-05	197	68	5	0dd71e399f253787fa546a7e90c5373180b89ffd
ToppCell	Control_saline\|World / Treatment groups by lineage, cell group, cell type	HMCN1 SPTAN1 GNAS PLEC NDRG4	1.34e-05	199	68	5	11c9c1779caceb725ecccf3f23b7d4e6dbd1af64
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Vein\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	HMCN1 MMP28 SPTAN1 PLEC BCR	1.34e-05	199	68	5	cfb624c7728046fc7f3ef071f57e4d7b013f3fef
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Vein\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	HMCN1 MMP28 SPTAN1 PLEC BCR	1.37e-05	200	68	5	7eb366b2c5394af7c77650bde6261e7dac67154e
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TRHDE ENOX1 HMCN1 SYNE1 RUNX1T1	1.37e-05	200	68	5	3dd022e974fec7013ba18f333da63f58fbf2dd7c
ToppCell	LPS_only-Endothelial-Endothelial-Artery\|LPS_only / Treatment groups by lineage, cell group, cell type	HMCN1 SPTAN1 GNAS BCR NDRG4	1.37e-05	200	68	5	b17eb1587ca86c3d40515128a00a8d8fd787fccf
ToppCell	Control_saline-Endothelial-Endothelial-Vein\|Control_saline / Treatment groups by lineage, cell group, cell type	FRMD4A HMCN1 MMP28 SPTAN1 PLEC	1.37e-05	200	68	5	e5f876910bc8cb390d9b46a48d9b6d4d57235551
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Artery\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	HMCN1 MMP28 SPTAN1 GNAS NDRG4	1.37e-05	200	68	5	77ae679c35d3b9e2b620f34129f3a8d47e922c65
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TRHDE ENOX1 HMCN1 SYNE1 RUNX1T1	1.37e-05	200	68	5	58b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCell	LPS-IL1RA+antiTNF-Unknown-Endothelial\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NCKIPSD MIOS MYO18B NDRG4	4.98e-05	132	68	4	46c80eab16a70da9f363a9fbdf50bccab0b287d7
ToppCell	LPS-IL1RA+antiTNF-Unknown\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NCKIPSD MIOS MYO18B NDRG4	4.98e-05	132	68	4	a022c3c41654166cb106f27dc54fa88e8c40f898
ToppCell	367C-Myeloid-Macrophage-SPP1+_Macrophage_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	ZNF773 MUC16 IQUB PLD4	6.99e-05	144	68	4	38ff324366ad5be626e3657c1e33277fc36ddd4c
ToppCell	pdx-Tumor_cells-T9\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	KMT2D SPTAN1 HNRNPLL DYNC1H1	6.99e-05	144	68	4	0b94d978262a826c9254145aa98c6c30240243f9
Drug	Ethotoin [86-35-1]; Down 200; 19.6uM; PC3; HT_HG-U133A	ITCH ALMS1 SMC3 PLCG1 GNAS SMC5 BBS9	1.34e-06	188	67	7	4545_DN
Drug	plakin	SYNE1 SPTAN1 GNAS PLEC DYNC1H1	4.34e-06	82	67	5	CID000018752
Drug	Myosmine [532-12-7]; Down 200; 27.4uM; PC3; HT_HG-U133A	SYNE1 SPTAN1 MIOS PLCG1 BBS9 KPNB1	2.36e-05	195	67	6	3737_DN
Drug	Isoconazole [27523-40-6]; Down 200; 9.6uM; PC3; HT_HG-U133A	SETMAR CUL9 GNAS BCR NDRG4 DHX30	2.43e-05	196	67	6	2056_DN
Drug	Meglumine [6284-40-8]; Up 200; 20.4uM; MCF7; HT_HG-U133A	SPTAN1 CUL9 PLCG1 BBS9 EML3 VPS13B	2.50e-05	197	67	6	5285_UP
Drug	1-amino-2-phosphonomethylcyclopropanecarboxylic acid	GRM4 GRM6	2.55e-05	3	67	2	ctd:C523415
Drug	Sulfasalazine [599-79-1]; Down 200; 10uM; PC3; HT_HG-U133A	ALMS1 SPTAN1 CD2BP2 BBS9 EML3 NDRG4	2.57e-05	198	67	6	6346_DN
Drug	2-Chloropyrazine [14508-49-7]; Down 200; 35uM; PC3; HT_HG-U133A	FRMD4A ALMS1 PLCG1 BBS9 NDRG4 ENOX2	2.72e-05	200	67	6	5750_DN
Disease	unipolar depression, alcohol dependence	TRHDE SEMA3A NEB	7.21e-04	78	66	3	EFO_0003761, MONDO_0007079
Disease	Sezary Syndrome	KMT2D PLCG1	1.67e-03	27	66	2	C0036920
Disease	Myopia	TRHDE ENOX1 ZNF92 GNAS VPS13B	1.72e-03	385	66	5	HP_0000545
Disease	Drug habituation	FRMD4A XPO6 SYNE1	2.21e-03	115	66	3	C0013170
Disease	Substance-Related Disorders	FRMD4A XPO6 SYNE1	2.21e-03	115	66	3	C0236969
Disease	Drug abuse	FRMD4A XPO6 SYNE1	2.21e-03	115	66	3	C0013146
Disease	Drug Use Disorders	FRMD4A XPO6 SYNE1	2.21e-03	115	66	3	C0013222
Disease	Drug Dependence	FRMD4A XPO6 SYNE1	2.21e-03	115	66	3	C1510472
Disease	Substance Dependence	FRMD4A XPO6 SYNE1	2.21e-03	115	66	3	C0038580
Disease	Substance Use Disorders	FRMD4A XPO6 SYNE1	2.21e-03	115	66	3	C0038586
Disease	Organic Mental Disorders, Substance-Induced	FRMD4A XPO6 SYNE1	2.21e-03	115	66	3	C0029231
Disease	Prescription Drug Abuse	FRMD4A XPO6 SYNE1	2.21e-03	115	66	3	C4316881

Protein segments in the cluster

Peptide	Gene	Start	Entry
VNYDLRNWRLLIDQL	TRHDE	691	Q9UKU6
DYERAEWRENIREQQ	BCR	851	P11274
RTLDNNRRNIWFAEF	GRM4	351	Q14833
VSLNELWNKYRERQR	ALMS1	3596	Q8TCU4
NRQFLDNLRDRLQEW	ECT2L	626	Q008S8
YHNVLSNWNRLRDRQ	APPBP2	536	Q92624
SNWNRLRDRQYSVTD	APPBP2	541	Q92624
RWQDRSSRENYLEEN	DHX30	951	Q7L2E3
NYRRRFNIDEVLQEW	RCOR1	426	Q9UKL0
LWAYRDLQTREDIRN	NIPSNAP2	236	O75323
RLNVIRNDNDSWDYT	HNRNPLL	246	Q8WVV9
LNRERLYWELSQLTN	MUC16	12471	Q8WXI7
NLSDARYKESWRNLR	NRAP	1266	Q86VF7
CQEADREELNYWIRR	RUNX1T1	381	Q06455
EENDSLRWQLDAYRN	ENOX2	416	Q16206
ILDYRNLNLEQWLFR	MRS2	151	Q9HD23
VRRDFADWYLEQLNS	IQGAP3	326	Q86VI3
SQRYRIQSEQFEDLW	BBS9	596	Q3SYG4
AVDYNLTWQRNDRDV	HMCN1	546	Q96RW7
QLRQLFERDWSSRYA	PLD4	476	Q96BZ4
QEIDLNDWQRHAIYR	ITCH	786	Q96J02
NYFLNRDAQIRDSWL	CD2BP2	106	O95400
RAAVSDELRQWYQRS	FRMD4A	921	Q9P2Q2
RSLENNRRNIWFAEF	GRM6	346	O15303
YLSCLQREENWQRRA	CCDC127	141	Q96BQ5
RAQQWRRARHNYNDL	GNAS	6	O95467
LSERADWQYSQRELD	ABHD17C	91	Q6PCB6
SEIDWQNSRRYIRNT	CFAP97D1	141	B2RV13
YQQRWLAIDANARRE	KPNB1	76	Q14974
LYNALEFWRQEELTR	IQUB	406	Q8NA54
EYLSNADERLRWQAS	DYNC1H1	3551	Q14204
WLLDQYLEQRETSRN	CUL9	1396	Q8IWT3
QLKNRYESRDREWAT	EML3	761	Q32P44
QEELRRQRYWLGEEQ	CROCCP3	96	Q8IVE0
EENDSLRWQLDAYRN	ENOX1	431	Q8TC92
QVARESYLQWLRDQE	OTUD5	401	Q96G74
RDDRYWRLDQAKLQA	MMP28	481	Q9H239
QSERNYLWREENAEQ	SMC3	466	Q9UQE7
RQDWQAYQHRLSETR	SYNE1	3576	Q8NF91
ERWTNNFREYNLHRV	MMP1	201	P03956
TQRWQRREISNFEYL	NBEA	2286	Q8NFP9
DEKWILYDNRRRSAQ	SETMAR	496	Q53H47
LYDNRRRSAQWLDQE	SETMAR	501	Q53H47
FWNMYNSRRDLDINR	NDRG4	201	Q9ULP0
SQRALVYWQFQRRNE	SEMA3A	601	Q14563
RRKDDAQQRSWALYE	NCKIPSD	391	Q9NZQ3
VRDAEDALYNLNRKW	SRSF12	61	Q8WXF0
EDLNAKWQRYNASRD	TNIP2	221	Q8NFZ5
EEWECLDSAQQRLYR	ZNF727	16	A8MUV8
EWQRLNPEQRNLYRD	ZIM3	21	Q96PE6
EEWQCLDTAQRNLYR	ZNF92	16	Q03936
EWTLLDQAQRDLYRD	ZNF846	21	Q147U1
ERVQYWIENYRNLLD	MIOS	691	Q9NXC5
RIIQEWQSRNERYQA	STYXL2	391	Q5VZP5
ALLELWELRRQQYEQ	SPTAN1	451	Q13813
WLRKQFYSVDRNRED	PLCG1	156	P19174
QEARLRQQWEQNSRY	TCHP	26	Q9BT92
ANELQLRWQEYRELV	PLEC	411	Q15149
QRAYWALLNQRRDQS	MYO18B	641	Q8IUG5
QEEWRLLDDAQRLLY	ZNF773	26	Q6PK81
WQDLDDAQRTLYRDV	ZNF717	36	Q9BY31
EEWEQLDLAQRTLYR	ZNF544	26	Q6NX49
EHYNRQEEWRRQLPE	VPS13B	3731	Q7Z7G8
DQQTEWQRYLRQSLE	XPO6	481	Q96QU8
RDTYDAVLWLRNNRD	SMC5	461	Q8IY18
EEWTLLDQTQRNLYR	ZNF559	26	Q9BR84
EEWECLDSAQQRLYR	ZNF736	16	B4DX44
LSYNQRSLQRWEKDE	KMT2D	1996	O14686
VWQNRFNYLEKARER	LRRIQ3	486	A6PVS8
NAKNRSDRLYREAWD	NEB	2471	P20929