Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessintraciliary retrograde transport

DYNC2H1 BBS1 DYNC2I1 WDR35

5.40e-06151684GO:0035721
GeneOntologyCellularComponentpericentriolar material

TUBG2 DYNC2I1 TUBG1 NEK1 AKAP9

2.45e-06281655GO:0000242
GeneOntologyCellularComponentH zone

DST ATP2A1

6.19e-0521652GO:0031673
GeneOntologyCellularComponentpolymeric cytoskeletal fiber

KRT8 KRT14 RPGRIP1L KRT15 KRT18 TUBG2 DYNC2H1 KRT27 CHMP1B NUMA1 AKNA CRHBP TUBG1 MYO3A DST DLC1 DNAH17 FHDC1 MX2

9.16e-0589916519GO:0099513
GeneOntologyCellularComponentnuclear matrix

KRT8 KRT18 AHCTF1 NUMA1 LGALS13 SMARCE1 ALOX5

1.25e-041401657GO:0016363
GeneOntologyCellularComponentpresynaptic active zone

PPFIA4 PPFIA2 PPFIA1 ZZEF1 KCNJ8 SCN8A BSN

1.31e-041411657GO:0048786
GeneOntologyCellularComponentsupramolecular fiber

KRT8 KRT14 RPGRIP1L KRT15 KRT18 TUBG2 DYNC2H1 KRT27 CHMP1B NUMA1 AKNA CRHBP TUBG1 MYO3A DST DLC1 KCNJ8 DNAH17 SCN8A FHDC1 ATP2A1 MX2

1.53e-04117916522GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

KRT8 KRT14 RPGRIP1L KRT15 KRT18 TUBG2 DYNC2H1 KRT27 CHMP1B NUMA1 AKNA CRHBP TUBG1 MYO3A DST DLC1 KCNJ8 DNAH17 SCN8A FHDC1 ATP2A1 MX2

1.69e-04118716522GO:0099081
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN8A SCN10A CACNA1G

3.03e-04171653GO:0001518
GeneOntologyCellularComponentnuclear periphery

KRT8 KRT18 AHCTF1 NUMA1 LGALS13 SMARCE1 ALOX5

4.26e-041711657GO:0034399
GeneOntologyCellularComponentdendrite

INPP5A ANXA3 PPFIA2 PPFIA1 LRRK2 NUMA1 MPDZ NFASC INPP5F GRM5 CRHBP OPRK1 AKAP9 SCN8A CACNA1G BSN ALOX5

4.60e-0485816517GO:0030425
GeneOntologyCellularComponentdendritic tree

INPP5A ANXA3 PPFIA2 PPFIA1 LRRK2 NUMA1 MPDZ NFASC INPP5F GRM5 CRHBP OPRK1 AKAP9 SCN8A CACNA1G BSN ALOX5

4.72e-0486016517GO:0097447
GeneOntologyCellularComponentcytoplasmic region

RPGRIP1L DYNC2H1 LRRK2 NUMA1 BBS1 DST WDR11 DNAH17 WDR35 BSN

5.98e-0436016510GO:0099568
GeneOntologyCellularComponentplasma membrane bounded cell projection cytoplasm

RPGRIP1L DYNC2H1 LRRK2 BBS1 DST WDR11 DNAH17 WDR35 BSN

9.61e-043171659GO:0032838
GeneOntologyCellularComponentmicrotubule

RPGRIP1L TUBG2 DYNC2H1 CHMP1B NUMA1 AKNA CRHBP TUBG1 DST DNAH17 FHDC1 MX2

1.11e-0353316512GO:0005874
GeneOntologyCellularComponentsodium channel complex

SCN8A SCN10A CACNA1G

1.52e-03291653GO:0034706
HumanPhenoAbnormal epiglottis morphology

KRT14 DYNC2H1 DYNC2I1 NEK1 WDR35

3.54e-0623555HP:0005483
HumanPhenoPostaxial hand polydactyly

RPGRIP1L DYNC2H1 BBS1 DYNC2I1 KIAA0753 NEK1 KIAA0825 WDR35

6.44e-0695558HP:0001162
HumanPhenoPostaxial foot polydactyly

RPGRIP1L DYNC2H1 BBS1 DYNC2I1 KIAA0753 NEK1 KIAA0825

9.91e-0672557HP:0001830
HumanPhenoUrethrovaginal fistula

DYNC2H1 DYNC2I1 WDR35

2.33e-056553HP:0008716
HumanPhenoThoracic dysplasia

DYNC2I1 NEK1 WDR35

2.33e-056553HP:0006644
HumanPhenoBifid epiglottis

DYNC2H1 DYNC2I1 WDR35

4.04e-057553HP:0010564
HumanPhenoAbnormal fifth toe morphology

RPGRIP1L DYNC2H1 BBS1 DYNC2I1 KIAA0753 NEK1 KIAA0825

5.74e-0594557HP:0010322
HumanPhenoUrethral fistula

DYNC2H1 DYNC2I1 WDR35

6.42e-058553HP:0010480
HumanPhenoDystrophic toenail

KRT14 ITGB4 DST SMARCE1

7.70e-0522554HP:0001810
HumanPhenoBifid tongue

DYNC2H1 DYNC2I1 NEK1 WDR35

1.30e-0425554HP:0010297
HumanPhenoLethal skeletal dysplasia

DYNC2H1 DYNC2I1 WDR35

1.36e-0410553HP:0005716
HumanPhenoDuplication involving bones of the feet

RPGRIP1L DYNC2H1 BBS1 DYNC2I1 KIAA0753 NEK1 SEC24C KIAA0825

1.53e-04147558HP:0009136
HumanPhenoFoot polydactyly

RPGRIP1L DYNC2H1 BBS1 DYNC2I1 KIAA0753 NEK1 SEC24C KIAA0825

1.53e-04147558HP:0001829
HumanPhenoPostaxial polydactyly

RPGRIP1L DYNC2H1 BBS1 DYNC2I1 KIAA0753 NEK1 KIAA0825 WDR35

1.61e-04148558HP:0100259
HumanPhenoAbnormal dermoepidermal hemidesmosome morphology

KRT14 ITGB4 DST

1.85e-0411553HP:0032449
HumanPhenoUterus didelphys

DYNC2H1 DYNC2I1 WDR35

2.45e-0412553HP:0003762
HumanPhenoAbnormal dermoepidermal junction morphology

KRT14 ITGB4 DST

2.45e-0412553HP:0031538
MousePhenoabnormal esophagus morphology

MGAT4D KRT14 KRT15 DYNC2H1 ITGB4 WDR35 MMP15

2.40e-06661297MP:0000467
DomainCOE

EBF3 EBF1 EBF2

2.45e-0641603PS01345
DomainTranscription_factor_COE

EBF3 EBF1 EBF2

2.45e-0641603IPR003523
DomainCOE_HLH

EBF3 EBF1 EBF2

2.45e-0641603IPR032201
DomainCOE_DBD

EBF3 EBF1 EBF2

2.45e-0641603IPR032200
DomainTranscription_factor_COE_CS

EBF3 EBF1 EBF2

2.45e-0641603IPR018350
DomainCOE1_HLH

EBF3 EBF1 EBF2

2.45e-0641603PF16423
DomainCOE1_DBD

EBF3 EBF1 EBF2

2.45e-0641603PF16422
DomainLiprin

PPFIA4 PPFIA2 PPFIA1

1.21e-0561603IPR029515
DomainKeratin_I

KRT8 KRT14 KRT15 KRT18 KRT27

3.59e-05441605IPR002957
DomainGamma_tubulin

TUBG2 TUBG1

7.29e-0521602IPR002454
DomainIg_E-set

EBF3 CD109 EBF1 EBF2 KCNJ8 ASCC3

2.73e-041041606IPR014756
DomainHelicase_C

TDRD9 CHD9 BTAF1 ZRANB3 HFM1 ASCC3

3.19e-041071606PF00271
DomainHELICc

TDRD9 CHD9 BTAF1 ZRANB3 HFM1 ASCC3

3.19e-041071606SM00490
DomainHelicase_C

TDRD9 CHD9 BTAF1 ZRANB3 HFM1 ASCC3

3.35e-041081606IPR001650
DomainHELICASE_CTER

TDRD9 CHD9 BTAF1 ZRANB3 HFM1 ASCC3

3.52e-041091606PS51194
DomainHELICASE_ATP_BIND_1

TDRD9 CHD9 BTAF1 ZRANB3 HFM1 ASCC3

3.52e-041091606PS51192
DomainDEXDc

TDRD9 CHD9 BTAF1 ZRANB3 HFM1 ASCC3

3.52e-041091606SM00487
DomainFilament

KRT8 KRT14 KRT15 KRT18 KRT27

3.58e-04711605SM01391
DomainHelicase_ATP-bd

TDRD9 CHD9 BTAF1 ZRANB3 HFM1 ASCC3

3.70e-041101606IPR014001
DomainIF

KRT8 KRT14 KRT15 KRT18 KRT27

3.82e-04721605PS00226
DomainFilament

KRT8 KRT14 KRT15 KRT18 KRT27

4.07e-04731605PF00038
DomainSec63

HFM1 ASCC3

4.33e-0441602PF02889
DomainSec63

HFM1 ASCC3

4.33e-0441602SM00973
DomainSec63-dom

HFM1 ASCC3

4.33e-0441602IPR004179
DomainIF

KRT8 KRT14 KRT15 KRT18 KRT27

4.90e-04761605IPR001664
DomainSAM_2

PPFIA4 PPFIA2 PPFIA1 DLC1

4.93e-04431604PF07647
Pubmed

Overexpression of Flii during Murine Embryonic Development Increases Symmetrical Division of Epidermal Progenitor Cells.

KRT14 KRT15 TUBG2 TUBG1 TLN1

5.55e-0914173534361001
Pubmed

Ebf factors and MyoD cooperate to regulate muscle relaxation via Atp2a1.

EBF3 EBF1 EBF2 ATP2A1

2.05e-087173424786561
Pubmed

Huntingtin regulates mammary stem cell division and differentiation.

KRT8 KRT14 TUBG2 NUMA1 TUBG1

2.34e-0818173524749073
Pubmed

Expression of testicular germ cell genes identified by differential display analysis.

ANKRD20A3P ANKRD20A8P ANKRD20A4P ANKRD20A1

4.08e-088173412634303
Pubmed

Type II keratins precede type I keratins during early embryonic development.

KRT8 KRT14 KRT15 KRT18

7.31e-089173416180309
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

MAP7D3 TTC28 PPFIA1 MPDZ NEK1 VPS13D DST ARHGAP29 ASCC3 VCPIP1

1.07e-072091731036779422
Pubmed

The characterization of the Olf-1/EBF-like HLH transcription factor family: implications in olfactory gene regulation and neuronal development.

EBF3 EBF1 EBF2

1.21e-07317339151732
Pubmed

Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis.

KRT8 KRT14 KRT15 KRT18

1.21e-0710173410852826
Pubmed

Interaction of plectin with keratins 5 and 14: dependence on several plectin domains and keratin quaternary structure.

KRT8 KRT14 KRT15 KRT18

1.21e-0710173424940650
Pubmed

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation.

KRT8 KRT14 KRT15 KRT18 ITGB4

2.12e-0727173527807348
Pubmed

ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis.

KRT8 KRT14 KRT18 ITGB4

2.84e-0712173421127502
Pubmed

Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development.

EBF3 EBF1 EBF2

4.82e-07417339151733
Pubmed

Cloning of a novel Olf-1/EBF-like gene, O/E-4, by degenerate oligo-based direct selection.

EBF3 EBF1 EBF2

4.82e-074173312139918
Pubmed

Identification of a new sweat gland progenitor population in mice and the role of their niche in tissue development.

KRT8 KRT15 KRT18

4.82e-074173327693698
Pubmed

Treasure or artifact: a decade of p63 research speaks for itself.

KRT8 KRT14 KRT18

4.82e-074173319876067
Pubmed

Conversion of columnar to stratified squamous epithelium in the developing mouse oesophagus.

KRT8 KRT14 KRT18

4.82e-074173315992795
Pubmed

Developmental changes in cellular and extracellular structural macromolecules in the secondary palate and in the nasal cavity of the mouse.

KRT8 KRT14 KRT15 KRT18

5.69e-0714173420572855
Pubmed

RPGRIP1L is required for stabilizing epidermal keratinocyte adhesion through regulating desmoglein endocytosis.

KRT14 RPGRIP1L TUBG2 TUBG1

1.03e-0616173430689641
Pubmed

Formation of whisker-related principal sensory nucleus-based lemniscal pathway requires a paired homeodomain transcription factor, Drg11.

EBF3 EBF1 EBF2

1.20e-065173312917357
Pubmed

The mouse and human Liprin-alpha family of scaffolding proteins: genomic organization, expression profiling and regulation by alternative splicing.

PPFIA4 PPFIA2 PPFIA1

1.20e-065173319013515
Pubmed

Expression patterns of the coe/ebf transcription factor genes during chicken and mouse limb development.

EBF3 EBF1 EBF2

1.20e-065173315261831
Pubmed

Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD.

KRT8 KRT14 KRT18

1.20e-065173311684708
Pubmed

The ciliopathy gene Rpgrip1l is essential for hair follicle development.

KRT14 RPGRIP1L TUBG2 TUBG1

1.34e-0617173425398052
Pubmed

Characterization of human epiplakin: RNAi-mediated epiplakin depletion leads to the disruption of keratin and vimentin IF networks.

KRT8 KRT14 KRT18

2.39e-066173315671067
Pubmed

Family of Ebf/Olf-1-related genes potentially involved in neuronal differentiation and regional specification in the central nervous system.

EBF3 EBF1 EBF2

2.39e-06617339389446
Pubmed

Onset of keratin 17 expression coincides with the definition of major epithelial lineages during skin development.

KRT8 KRT14 KRT18

2.39e-06617339786956
Pubmed

Analyses of the spatiotemporal expression and subcellular localization of liprin-α proteins.

PPFIA4 PPFIA2 PPFIA1

2.39e-066173321618221
Pubmed

Human plasma proteome analysis by multidimensional chromatography prefractionation and linear ion trap mass spectrometry identification.

KRT8 KRT18 DNAH17

2.39e-066173315822942
Pubmed

mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking.

PPFIA4 PPFIA2 PPFIA1 BSN

2.69e-0620173423791195
Pubmed

AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis.

KRT8 KRT14 KRT18 ITGB4

3.31e-0621173418824566
Pubmed

Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting.

PPFIA4 PPFIA2 PPFIA1

4.17e-067173311931740
Pubmed

Mammalian RanBP1 regulates centrosome cohesion during mitosis.

TUBG2 TUBG1 AKAP9

4.17e-067173312840069
Pubmed

The ciliary protein RPGRIP1L governs autophagy independently of its proteasome-regulating function at the ciliary base in mouse embryonic fibroblasts.

RPGRIP1L TUBG2 TUBG1

4.17e-067173329372668
Pubmed

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

GEMIN2 DYNC2H1 MCC MPDZ EBF1 PKD1L2 ITGB4 DST TLN1 SCN10A

5.40e-063221731026514267
Pubmed

Identification of trichoplein, a novel keratin filament-binding protein.

KRT8 KRT14 KRT18

6.65e-068173315731013
Pubmed

Proteomic analysis of mammalian primary cilia.

DYNC2I1 WDR11 WDR35

6.65e-068173322326026
Pubmed

Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling.

TUBG2 BBS1 TUBG1

6.65e-068173326540106
Pubmed

Induced multipotency in adult keratinocytes through down-regulation of ΔNp63 or DGCR8.

KRT8 KRT14 KRT18

6.65e-068173324449888
Pubmed

Lessons from keratin transgenic and knockout mice.

KRT8 KRT14 KRT18

6.65e-06817339932492
Pubmed

Genetic disruptions of O/E2 and O/E3 genes reveal involvement in olfactory receptor neuron projection.

EBF3 EBF1 EBF2

6.65e-068173314993187
Pubmed

A ciliopathy complex builds distal appendages to initiate ciliogenesis.

TUBG2 TUBG1 KIAA0753

6.65e-068173334241634
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

KRT8 MAP7D3 KRT18 TTC28 DOCK11 PPFIA1 MPDZ INPP5F KIAA0753 NEK1 VPS13D DST DLC1 AKAP9 DOP1A VCPIP1

7.03e-068611731636931259
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

NCOA3 TTC28 L3MBTL2 GEMIN2 INPP4A PPFIA1 INPP5F NEK1 DST ASCC3 VCPIP1

8.76e-064181731134709266
Pubmed

Integrin β4 regulation of PTHrP underlies its contribution to mammary gland development.

KRT14 LAMA1 ITGB4

9.94e-069173326432258
Pubmed

Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules.

TUBG2 NUMA1 TUBG1

9.94e-069173311956313
Pubmed

Dynamic changes of NuMA during the cell cycle and possible appearance of a truncated form of NuMA during apoptosis.

TUBG2 NUMA1 TUBG1

9.94e-06917338838651
Pubmed

Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting.

PPFIA4 PPFIA2 PPFIA1

9.94e-069173312629171
Pubmed

Disruption of reelin signaling alters mammary gland morphogenesis.

KRT8 KRT14 KRT18

9.94e-069173321266412
Pubmed

Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins.

PPFIA4 PPFIA2 PPFIA1

9.94e-069173312923177
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

NCOA3 RPGRIP1L MAP7D3 RB1 EBF3 DYNC2H1 MCC BBS1 DYNC2I1 NDUFA9 CLOCK TUBG1 ESF1 NEK1 TRAP1 SBNO1 PIK3R1 PTPRQ WDR35 VSIG8

1.03e-0513211732027173435
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

PRKD2 MCM8 TTC28 RB1 PPFIA1 AHCTF1 PER1 MCC CHD9 CRACR2B ZZEF1 TUBG1 DNTTIP2 DROSHA PIK3R1 SMARCE1 ASCC3 ARMC6

1.27e-0511161731831753913
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

CTNNAL1 MAP7D3 TTC28 PPFIA1 AHCTF1 NUMA1 MPDZ PTPN11 DST SEC24C TLN1 ARHGAP29 ASCC3 VCPIP1

1.36e-057081731439231216
Pubmed

Ontogeny of the mouse vocal fold epithelium.

KRT8 KRT14 KRT18

1.41e-0510173325601450
Pubmed

Spatiotemporal expression pattern of keratins in skin of AP-2alpha-deficient mice.

KRT14 KRT15 KRT18

1.41e-0510173310571739
Pubmed

LGN plays distinct roles in oral epithelial stratification, filiform papilla morphogenesis and hair follicle development.

KRT8 KRT14 ITGB4

1.41e-0510173327317810
Pubmed

Immunolocalization patterns of cytokeratins during salivary acinar cell development in mice.

KRT8 KRT14 KRT18

1.41e-0510173329181608
Pubmed

A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.

KRT8 KRT14 KRT18 NDUFA9 ITGB4

1.48e-0562173526644517
Pubmed

New consensus nomenclature for mammalian keratins.

KRT8 KRT14 KRT15 KRT18 KRT27

1.60e-0563173516831889
Pubmed

The synaptic vesicle cycle.

PPFIA4 PPFIA2 PPFIA1 BSN

1.68e-0531173415217342
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

DTD1 KRT8 KRT14 KRT15 MAP7D3 KRT18 ANXA3 AHCTF1 CD109 NUMA1 NDUFA9 ITGB4 DNTTIP2 ESF1 DST WDR11 DNAJC11 GAPDHS ASCC3

1.77e-0512571731936526897
Pubmed

Control of hindbrain motor neuron differentiation by the homeobox gene Phox2b.

EBF3 EBF1 EBF2

1.94e-0511173310704382
Pubmed

Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival.

KRT14 ITGB4 DST

1.94e-051117338707838
Pubmed

Antigen expression of human eccrine sweat glands.

KRT8 KRT14 KRT18

1.94e-0511173319032382
Pubmed

Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus.

KRT14 ITGB4 DST

1.94e-0511173312802069
Pubmed

Current insights into the formation and breakdown of hemidesmosomes.

KRT14 ITGB4 DST

1.94e-0511173316757171
Pubmed

The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signaling.

TUBG2 DYNC2H1 TUBG1

1.94e-0511173328291807
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

RB1 DOCK11 PPFIA2 LAMA1 IGDCC3 NFASC ANKRD20A3P ZZEF1 DST ZBED4 DROSHA TLN1 SCN8A ALOX5

2.08e-057361731429676528
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

MAP7D3 TTC28 AHCTF1 NUMA1 MPDZ ESF1 NEK1 PTPN11 TLN1 SMARCE1 ASCC3 VCPIP1

2.17e-055491731238280479
Pubmed

Cytokeratins 18 and 8 are poor prognostic markers in patients with squamous cell carcinoma of the oesophagus.

KRT8 KRT18

2.46e-052173219755983
Pubmed

Formation of Mallory body-like inclusions and cell death induced by deregulated expression of keratin 18.

KRT8 KRT18

2.46e-052173212388748
Pubmed

A disease- and phosphorylation-related nonmechanical function for keratin 8.

KRT8 KRT18

2.46e-052173216818723
Pubmed

Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies.

KRT8 KRT18

2.46e-052173212724528
Pubmed

Absence of keratin 8 or 18 promotes antimitochondrial autoantibody formation in aging male mice.

KRT8 KRT18

2.46e-052173226399787
Pubmed

Keratins regulate colonic epithelial cell differentiation through the Notch1 signalling pathway.

KRT8 KRT18

2.46e-052173228475172
Pubmed

The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors.

PTPN11 PIK3R1

2.46e-052173211593409
Pubmed

O-GlcNAcylation determines the solubility, filament organization, and stability of keratins 8 and 18.

KRT8 KRT18

2.46e-052173220729549
Pubmed

Genetic background effects of keratin 8 and 18 in a DDC-induced hepatotoxicity and Mallory-Denk body formation mouse model.

KRT8 KRT18

2.46e-052173222449798
Pubmed

Sialylation of MUC4β N-glycans by ST6GAL1 orchestrates human airway epithelial cell differentiation associated with type-2 inflammation.

ST6GAL1 MUC4

2.46e-052173230730306
Pubmed

Keratins as susceptibility genes for end-stage liver disease.

KRT8 KRT18

2.46e-052173216143128
Pubmed

The basal keratin network of stratified squamous epithelia: defining K15 function in the absence of K14.

KRT14 KRT15

2.46e-05217327539810
Pubmed

Keratins 8 and 18 are type II acute-phase responsive genes overexpressed in human liver disease.

KRT8 KRT18

2.46e-052173224930437
Pubmed

Keratins modulate the shape and function of hepatocyte mitochondria: a mechanism for protection from apoptosis.

KRT8 KRT18

2.46e-052173219825937
Pubmed

NEK1 and DYNC2H1 are both involved in short rib polydactyly Majewski type but not in Beemer Langer cases.

DYNC2H1 NEK1

2.46e-052173222499340
Pubmed

Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near human KRT8/18.

KRT8 KRT18

2.46e-052173232031521
Pubmed

Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2.

PTPN11 PIK3R1

2.46e-052173212024020
Pubmed

Ectopic coexpression of keratin 8 and 18 promotes invasion of transformed keratinocytes and is induced in patients with cutaneous squamous cell carcinoma.

KRT8 KRT18

2.46e-052173220659422
Pubmed

Intestinal cell barrier function in vitro is severely compromised by keratin 8 and 18 mutations identified in patients with inflammatory bowel disease.

KRT8 KRT18

2.46e-052173224915158
Pubmed

Insights into the mechanical properties of epithelial cells: the effects of shear stress on the assembly and remodeling of keratin intermediate filaments.

KRT8 KRT18

2.46e-052173219246484
Pubmed

Absence of keratins 8 and 18 in rodent epithelial cell lines associates with keratin gene mutation and DNA methylation: Cell line selective effects on cell invasion.

KRT8 KRT18

2.46e-052173225882495
Pubmed

MTOC reorientation occurs during FcgammaR-mediated phagocytosis in macrophages.

TUBG2 TUBG1

2.46e-052173217442887
Pubmed

Keratin 8 and 18 expression in mesenchymal progenitor cells of regenerating limbs is associated with cell proliferation and differentiation.

KRT8 KRT18

2.46e-05217329415422
Pubmed

Early B Cell Factor Activity Controls Developmental and Adaptive Thermogenic Gene Programming in Adipocytes.

EBF1 EBF2

2.46e-052173232130892
Pubmed

Understanding the role of keratins 8 and 18 in neoplastic potential of breast cancer derived cell lines.

KRT8 KRT18

2.46e-052173223341946
Pubmed

Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the carbon tetrachloride and thioacetamide models.

KRT8 KRT18

2.46e-052173218395095
Pubmed

No circadian rhythms in testis: Period1 expression is clock independent and developmentally regulated in the mouse.

PER1 CLOCK

2.46e-052173212511614
Pubmed

Changes in keratin 8/18 expression in human granulosa cell lineage are associated to cell death/survival events: potential implications for the maintenance of the ovarian reserve.

KRT8 KRT18

2.46e-052173229401296
Pubmed

Cytokeratin 8/18 is a useful immunohistochemical marker for hepatocellular proliferative lesions in mice.

KRT8 KRT18

2.46e-052173220035116
Pubmed

Overexpression of γ-tubulin in non-small cell lung cancer.

TUBG2 TUBG1

2.46e-052173222806905
Pubmed

Recruitment of the tyrosine phosphatase Src homology 2 domain tyrosine phosphatase-2 to the p85 subunit of phosphatidylinositol-3 (PI-3) kinase is required for insulin-like growth factor-I-dependent PI-3 kinase activation in smooth muscle cells.

PTPN11 PIK3R1

2.46e-052173216306077
Pubmed

Keratin variants predispose to acute liver failure and adverse outcome: race and ethnic associations.

KRT8 KRT18

2.46e-052173220538000
InteractionTTC23 interactions

KRT14 KRT15 RB1 KRT27 PPFIA4 TRIM10 TRAP1 DST KIAA1328 VCPIP1

8.60e-0620816510int:TTC23
InteractionKRT72 interactions

KRT8 KRT14 KRT15 KRT18 KRT27 NUMA1

8.65e-06591656int:KRT72
InteractionANKRD20A4P interactions

ANKRD20A2P ANKRD20A4P ANKRD20A1

1.06e-0561653int:ANKRD20A4P
InteractionANKRD20A2P interactions

ANKRD20A2P ANKRD20A4P ANKRD20A1

1.84e-0571653int:ANKRD20A2P
Cytoband12p12.2

SLCO1B7 GYS2

1.40e-045173212p12.2
CytobandEnsembl 112 genes in cytogenetic band chr10q26

MTG1 EBF3 INPP5A INPP5F PSTK WDR11

1.43e-042071736chr10q26
CytobandEnsembl 112 genes in cytogenetic band chr17q21

KRT14 KRT15 TUBG2 KRT27 IFI35 TUBG1 SMARCE1 CACNA1G

4.60e-044731738chr17q21
GeneFamilyKeratins, type I

KRT14 KRT15 KRT18 KRT27

3.23e-05281194608
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

NCOA3 TTC28 RB1 PPFIA1 AHCTF1 CHD9 BTAF1 INPP5F ZZEF1 CLOCK NEK1 PPP2R3A PTPN9 PTPRA DST DLC1 AKAP9 ARHGAP29 ASCC3

3.51e-0685617119M4500
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN

NCOA3 RB1 PPFIA1 CHD9 INPP5F CLOCK PPP2R3A PTPRA DST DLC1 AKAP9 ARHGAP29 ASCC3

1.27e-0546617113M13522
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

TTC28 DOCK11 PPFIA2 GPR141 MPDZ EBF2 NEK1 PLXDC2 NRK

4.58e-08184173967164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCellcellseq-Epithelial-Epithelial_Glandular-SMG_Basal/Duct|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KRT8 KRT14 KRT18 ANXA3 ST6GAL1 CRACR2B NAALADL2 SLCO1B7 MUC4

6.31e-08191173930e7cc5f7eadf90ab0900a73fdfe48f9a1adcbfb
ToppCellcellseq-Epithelial-Epithelial_Glandular-SMG_Basal/Duct-SMG_Basal/Duct|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KRT8 KRT14 KRT18 ANXA3 ST6GAL1 CRACR2B NAALADL2 SLCO1B7 MUC4

6.31e-08191173941d2f5278f6d5f52a5bdf4f3df70969481c00162
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

DOCK11 PPFIA2 NFASC EBF1 GPR183 EBF2 MYO3A KCNJ8 ARHGAP29

6.59e-08192173955f95454399fd533df75db06584eaa48d6ee3830
ToppCell3'-Broncho-tracheal|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT8 KRT14 KRT15 KRT18 ITGB4 DST RASSF6 AOPEP MUC4

8.22e-0819717395d33f8a6940431093e927b186fb9b630a89d8ec1
ToppCell3'-Broncho-tracheal-Epithelial|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT8 KRT14 KRT15 KRT18 ITGB4 DST RASSF6 AOPEP MUC4

8.58e-081981739aa6e7218ee6230902854e66c444b544218b30c0e
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-mature_NK_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TDRD9 PPFIA2 DYNC2I1 EPS8L1 TXK PTPRQ TIGD3 MX2

2.10e-0715917384000ed0d3b7d488722bcd0042fa2ff4405aaab82
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-Natural_Killer_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TDRD9 PPFIA2 DYNC2I1 EPS8L1 TXK PTPRQ TIGD3 MX2

2.10e-0715917387619d0d49738dd08daf01b42664691a5323aa793
ToppCellfacs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l22|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TDRD9 PPFIA2 DYNC2I1 EPS8L1 TXK PTPRQ TIGD3 MX2

2.92e-071661738bcdaab49bde5beba750b76fdcc3781a3c12c4fff
ToppCellfacs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TDRD9 PPFIA2 DYNC2I1 EPS8L1 TXK PTPRQ TIGD3 MX2

2.92e-0716617385e3b998d740b24f790fad37350d704ca0ea10b77
ToppCellBAL-Severe-Epithelial-Epithelial-undefined_Epi-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

KRT8 KRT15 KRT18 ANXA3 EPS8L1 ITGB4 ARHGAP29 MUC4

4.97e-0717817389a3ef66814dfca7b37024e7f79e86ea8c72ae10f
ToppCellBAL-Severe-Epithelial-Epithelial-undefined_Epi|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

KRT8 KRT15 KRT18 ANXA3 EPS8L1 ITGB4 ARHGAP29 MUC4

4.97e-07178173819b5432aa1d7f616d58a106543c18cf2d7ca840c
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT8 KRT14 KRT15 KRT18 LRRC72 CD109 VILL UPK2

5.64e-071811738a5e770b5b5d57cbac18560828e89f7c96b687743
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT8 KRT14 KRT15 KRT18 LRRC72 CD109 VILL UPK2

5.64e-071811738504b1af1951a7a20ef5db69d84c20630ec64095b
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT8 KRT14 KRT15 KRT18 LRRC72 CD109 VILL UPK2

5.64e-071811738a55ec36d2393f7a376feb42b22aee75dfdf4c383
ToppCellfacs-BAT-Fat-24m-Epithelial-Epcam+|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT15 MCM8 KRT18 CD109 ITGB4 RASSF6 FHDC1 MUC4

6.93e-071861738b18d7398279a2d42414318aeb70514fd402f5a0a
ToppCellSevere_COVID-19-Epithelial-undefined_Epi|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

KRT8 KRT15 KRT18 ANXA3 EPS8L1 ITGB4 ARHGAP29 MUC4

7.82e-0718917388cbd35320c7e7ff013ef0c0f13f8d875db1c53cd
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

DOCK11 PPFIA2 NFASC EBF1 EBF2 MYO3A KCNJ8 ARHGAP29

8.80e-0719217385000440dc1ed17e7474d340921bdff945646f27e
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT8 KRT18 RB1 CRACR2B MRPL14 VILL MMP15 MUC4

9.15e-0719317381526f51b589a7dc7a28f35f0e788dc38d338d2bc
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RPGRIP1L DYNC2H1 DYNC2I1 MPDZ CCDC175 ZBBX AKAP9 KIAA0825

1.07e-06197173874a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT8 KRT14 KRT15 KRT18 ITGB4 DST RASSF6 AOPEP

1.11e-061981738240e1aa0594ee6de530b2f97d5e392c5fcbf278b
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT8 KRT14 KRT15 KRT18 ITGB4 DST RASSF6 AOPEP

1.11e-0619817389a229167d4da4abf8c336dfe5cfdf57db756fc8b
ToppCellBronchial_Biopsy|World / Tissue, Lineage and Cell class of Lung Cells from 10X

KRT8 KRT15 KRT18 ITGB4 DST AKAP9 RASSF6 AOPEP

1.11e-061981738f5b7013045b61fc56894f80092f799770dde1c8f
ToppCellcellseq-Epithelial-Epithelial_Airway-Basal/Suprabasal|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KRT8 KRT14 KRT15 KRT18 ITGB4 RASSF6 AOPEP MUC4

1.15e-061991738974f71b56f66243c78f2f297a1540e0e186df530
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT8 KRT14 KRT15 KRT18 ITGB4 DST RASSF6 MUC4

1.15e-061991738c88a28a73f54dc571f2ff1e4b55073f83cbead2c
ToppCellproximal-3-Epithelial-Basal|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KRT8 KRT15 KRT18 ANXA3 ITGB4 DST RASSF6 AOPEP

1.20e-0620017388083047c213488e40b975013e3c5c43f7c0c15b2
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_basal-Basal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

KRT8 KRT14 KRT15 KRT18 ITGB4 DST RASSF6 MUC4

1.20e-0620017389da214f756a03516eaafde00289b90f69623b9f3
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-Basal_1-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KRT8 KRT14 KRT15 KRT18 ITGB4 DST RASSF6 AOPEP

1.20e-0620017388cfbde43c5e66269ad128aa5398b1517667d7d36
ToppCellproximal-Epithelial-Basal-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KRT8 KRT15 KRT18 ANXA3 ITGB4 DST RASSF6 AOPEP

1.20e-062001738f5d48f521abbd1e07de05f2b3768ad2f9675f1e1
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-Basal_1|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

KRT8 KRT14 KRT15 KRT18 ITGB4 DST RASSF6 AOPEP

1.20e-06200173861811380d9252f12f27b7ad4752380b52692677f
ToppCellcontrol|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

KRT8 KRT18 ITGB4 DST AKAP9 RASSF6 AOPEP MUC4

1.20e-06200173897f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCellParenchyma_COVID-19-Epithelial-TX-Basal_1|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

KRT8 KRT14 KRT15 KRT18 ITGB4 DST RASSF6 AOPEP

1.20e-062001738592c7c3ded409a9957cbcdc62fcc213fa8eae598
ToppCellproximal-Epithelial-Basal|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KRT8 KRT15 KRT18 ANXA3 ITGB4 DST RASSF6 AOPEP

1.20e-062001738c6a491d3e2dae6618f25dc3c9aac08f657348168
ToppCell10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_dendritic-CD141-positive_myeloid_dendritic_cell|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

KRT18 CD109 MPDZ CCDC175 NAALADL2 CRHBP RASSF6

2.88e-0615817374f3ea658e032555c2098d016475381c8d1071699
ToppCellASK428-Epithelial-Secretory|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

KRT15 MCM8 ITGB4 ALKBH1 RASSF6 UPK2 MUC4

4.67e-0617017379e275c4a70f9866f770fbdb0fe14a577287fe290
ToppCellwk_15-18-Epithelial-Proximal_epithelial-SMG_basal_1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

KRT8 ABCA3 KRT14 KRT18 CRACR2B RASSF6 C12orf54

5.44e-061741737aceca0a22bb1e380835e792681cfc9b752fb5496
ToppCellfacs-Trachea-nan-18m-Epithelial-basal_epithelial_cell_of_tracheobronchial_tree|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT8 KRT14 KRT15 KRT18 KRT27 ITGB4 RASSF6

5.65e-061751737eb87275da6f61ecb4fbc89421dfd27bead1e0f48
ToppCellnucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KRT14 KRT15 MCC ITGB4 RASSF6 PTPRQ MUC4

6.09e-061771737cbad1a23851151dbef01ea2af960e6f0944f838b
ToppCellnucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KRT14 KRT15 MCC ITGB4 RASSF6 PTPRQ MUC4

6.09e-061771737ce86dfaeb74d995a19aea62f0fb15c4c0bb854b0
ToppCellBAL-Severe-Epithelial-Epithelial-undefined_Epi|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KRT8 KRT15 KRT18 ANXA3 EPS8L1 ITGB4 MUC4

6.32e-06178173749a2271718637522f74334068d252963ee13b1ce
ToppCellBAL-Severe-Epithelial-Epithelial-undefined_Epi-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KRT8 KRT15 KRT18 ANXA3 EPS8L1 ITGB4 MUC4

6.32e-061781737b413a634283550fa224db7d0d05956e3f64694a1
ToppCellTCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-1|TCGA-Liver / Sample_Type by Project: Shred V9

RPGRIP1L ANXA3 EPS8L1 ITGB4 KIAA0753 UNC5A PPP2R3A

6.32e-06178173751c59dabf2d7aef1b1964f6f766d5ec07ef90f5a
ToppCell15-Airway-Epithelial-Submucosal_gland|Airway / Age, Tissue, Lineage and Cell class

KRT8 KRT14 KRT18 ANXA3 LAMA1 CRACR2B RASSF6

6.79e-061801737283bb0d58811947bfda4e286b9ec87d869c8e29e
ToppCellwk_15-18-Epithelial-Proximal_epithelial-basal_late|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

KRT8 KRT15 KRT18 UBD ANXA3 ITGB4 RASSF6

6.79e-061801737255097d8eb244a32eb2ecd0e7e48e1a20bafb5cd
ToppCellCOPD-Epithelial-Basal|World / Disease state, Lineage and Cell class

KRT8 KRT15 KRT18 MCC ITGB4 PTPRQ MUC4

7.05e-0618117376d8a886b4afe729f8a05b9c0f4ea9375de735da4
ToppCellBasal|World / shred by cell class for mouse tongue

KRT14 CTNNAL1 KRT15 ITGB4 DST AOPEP TLN1

7.57e-061831737c6729a207526ff4aa48176207b9353176f631fea
ToppCellControl-Myeloid-cDC1|Myeloid / Disease state, Lineage and Cell class

GPR141 ANKRD20A2P ANKRD20A3P ANKRD20A8P INPP5F ANKRD20A4P ANKRD20A1

7.84e-061841737c6affa0b12510363258f65e46bf2d47bf4a8e75f
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT8 KRT18 UBD ST6GAL1 EPS8L1 CRACR2B VILL

7.84e-061841737c2ca984551baf4becbefbe58bd1889828542b045
ToppCellControl-Epithelial-Basal|Epithelial / Disease state, Lineage and Cell class

KRT15 MCC ITGB4 DST PLXDC2 RASSF6 PTPRQ

8.13e-061851737d5d6d13e2f20b54ca55645b9a757b8599f4fd897
ToppCellControl-Myeloid-cDC1|Control / Disease state, Lineage and Cell class

GPR141 ANKRD20A2P ANKRD20A3P ANKRD20A8P INPP5F ANKRD20A4P ANKRD20A1

8.42e-061861737b05c394aa3573ba855abc3066739ca193883b0c3
ToppCellCOVID-19-Fibroblasts-Airway_smooth_muscle|COVID-19 / group, cell type (main and fine annotations)

TTC28 PPFIA2 NFASC EBF1 ADCY5 DST AOPEP

8.72e-061871737464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DYNC2H1 ANXA3 EPS8L1 NAALADL2 DST NRK ARHGAP29

8.72e-061871737f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCell15-Distal-Epithelial-Secretory_progenitor|Distal / Age, Tissue, Lineage and Cell class

KRT8 KRT15 KRT18 ANXA3 CRACR2B OPRK1 UPK2

9.02e-0618817379a64fb07de611de38d6f24673feb3b81a5e85384
ToppCell15-Distal-Mesenchymal-Pericyte|Distal / Age, Tissue, Lineage and Cell class

PPFIA2 NFASC EBF1 GPR183 EBF2 MYO3A KCNJ8

9.02e-0618817374963382e54aac06bf5047c7d725393db70667ee7
ToppCellfacs-Trachea-3m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_trachea|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KRT8 KRT15 KRT18 ITGB4 RASSF6 FHDC1 MUC4

9.02e-061881737137ed9958044fab7a13648affb469585d1c48cf6
ToppCellfacs-Trachea-3m-Epithelial-airway_epithelial-respiratory_basal_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KRT8 KRT15 KRT18 ITGB4 RASSF6 FHDC1 MUC4

9.02e-0618817378ffb5394f7b00ea483a5fe4df894d22fda935e5c
ToppCellCTRL-Lymphoid-B_cell|Lymphoid / Disease state, Lineage and Cell class

PRKD2 NCOA3 RB1 LRRK2 ST6GAL1 EBF1 INPP5F

9.34e-06189173714f3a8c0f4f057ad4e6839b4c3eeaf956d6dc92e
ToppCellTCGA-Cervix-Primary_Tumor-Cervical_Carcinoma|TCGA-Cervix / Sample_Type by Project: Shred V9

KRT14 KRT15 CD109 MCC PPP2R3A C12orf54 STX6

9.34e-061891737533c302df467d13ab639232daf4f8cafb808260b
ToppCell5'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT8 KRT15 KRT18 UBD EPS8L1 CRACR2B RASSF6

9.34e-061891737453b2acfa89e7279540109244cf986df34635df8
ToppCellIPF-Epithelial-Basal|IPF / Disease state, Lineage and Cell class

KRT8 KRT14 KRT15 KRT18 MCC ITGB4 RASSF6

9.67e-061901737ea19e9ce954f2dfde97388db9695325cd92ab88f
ToppCellIPF-Epithelial-Basal|Epithelial / Disease state, Lineage and Cell class

KRT14 KRT15 CD109 MCC ITGB4 DST PLXDC2

9.67e-0619017374f15842b424eefadbfe451875e517cf70e29607f
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial-luminal_progenitor_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT8 KRT18 CRACR2B MRPL14 WDR89 MMP15 MUC4

9.67e-0619017370bad41d19dc515e6bc61e699f4d56664cf2e72fd
ToppCell10x5'-bone_marrow-Lymphocytic_B-Memory_B_cells|bone_marrow / Manually curated celltypes from each tissue

NCOA3 KLF8 ST6GAL1 EBF1 GPR183 RASSF6 ALOX5

1.00e-05191173767479df0ca4c5a792fd604aded3f75609fec0888
ToppCellHippocampus-Endothelial|Hippocampus / BrainAtlas - Mouse McCarroll V32

ANXA3 LAMA1 EBF1 CRACR2B IFI35 KCNJ8 ARHGAP29

1.03e-05192173736deadab892d3e639a71f33697bb2d3cbbaa5372
ToppCellIPF-Epithelial-Basal|World / Disease state, Lineage and Cell class

KRT8 KRT14 KRT15 KRT18 MCC ITGB4 RASSF6

1.03e-0519217379b91e0b162e6f3ce86dd15cc33c2e745d069581f
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NUP210L OPRK1 MYO3A NRK PTPRQ BPIFB4 GAPDHS

1.07e-051931737315840bc48899f3a36d57b19197509de19716e3d
ToppCellcellseq-Epithelial-Epithelial_Glandular-Goblet|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KRT8 KRT18 ST6GAL1 EPS8L1 CRACR2B VILL MUC4

1.07e-05193173771bf8fb5314b79cb30f4eb9c8459b21f10cd6d35
ToppCellcellseq-Epithelial-Epithelial_Glandular-Goblet-Goblet|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KRT8 KRT18 ST6GAL1 EPS8L1 CRACR2B VILL MUC4

1.07e-051931737b05e110b13d35d34294357c8e1c4fd23bf4b6c92
ToppCellASK440-Epithelial-Secretory|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

KRT8 KRT15 KRT18 ANXA3 CRACR2B PTPRQ MUC4

1.07e-05193173750e98d91697c7af6a3de39e52edde6dd2b67b512
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

KLF8 CTNNAL1 DYNC2I1 ITGB4 ESF1 DST AKAP9

1.11e-0519417378985095f291c1b54e45f4edece49aa26e8c8b732
ToppCell11.5-Distal-Mesenchymal-Pericyte|Distal / Age, Tissue, Lineage and Cell class

KRT18 EBF1 GPR183 EBF2 MYO3A KCNJ8 ARHGAP29

1.11e-05194173708701590496cf85ff790e54a81493c61177e76ff
ToppCelldroplet-Mammary_Gland-nan-18m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT8 KRT18 CRACR2B MRPL14 VILL UPK2 MMP15

1.14e-05195173718220efbd2d6ce6aa7501744fe430b6b46f2fc30
ToppCelldroplet-Bladder-Unstain-18m-Epithelial-bladder_urothelial_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT8 KRT14 KRT15 KRT18 ITGB4 ACSBG1 MMP15

1.14e-051951737dde7a4e84f476d0cf8df240dae6290220c9cdcc9
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT8 KRT18 CRACR2B MRPL14 VILL MMP15 MUC4

1.14e-05195173725703e3c2e0512ef12e7aa389fad3968c3f13905
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-mesothelial_cell|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KRT8 KRT14 KRT18 DOCK11 ANXA3 EPS8L1 PTPRQ

1.14e-0519517378a9d05f7a5397836b7dfb8ae4f7c4896042ac0fe
ToppCelltumor_Lymph_Node_/_Brain|World / Location, Cell class and cell subclass

KRT8 KRT18 EPS8L1 CRACR2B AOPEP UPK2 MUC4

1.18e-051961737b39f938cbef54f08c53035738b97c76e7295733a
ToppCellBronchial-NucSeq-Epithelial-Epi_submucosal-gland-Myoepithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KRT14 KRT15 PPFIA2 LAMA1 NFASC ITGB4 ADCY5

1.18e-051961737a58bdf9de05d13d84211e09a933679d485bf8ab4
ToppCellBasal_cells-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

KRT14 KRT15 CD109 ITGB4 DST RASSF6 AOPEP

1.18e-0519617373b66f3a79b3f2ebacb4ad646f179e505ab38d6f0
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KRT8 KRT14 KRT18 DOCK11 ANXA3 EPS8L1 PTPRQ

1.18e-051961737147dc1ca5942df48a083cce39a9a7541430f8365
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT8 KRT18 UBD ST6GAL1 EPS8L1 VILL MUC4

1.18e-05196173760ea673ed887fe3890c5cf4ff4165384b76d7361
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT8 KRT18 ST6GAL1 EPS8L1 CRACR2B VILL MUC4

1.22e-051971737ec08a971e8dd9ad69359896c60ad77ff8af08fd0
ToppCellBasal_cells|World / lung cells shred on cell class, cell subclass, sample id

KRT14 KRT15 MCC ITGB4 DST RASSF6 AOPEP

1.22e-05197173724360b660000bdfb999d58fbf4e29585a97e1785
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ABCA3 EPS8L1 NAALADL2 MYO3A AOPEP C12orf54 PTPRQ

1.22e-051971737b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_basal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

KRT8 KRT15 KRT18 ITGB4 RASSF6 C12orf54 MUC4

1.22e-051971737de772bd2b4cda843777ac879b1087e6444199dfb
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PPFIA2 NFASC EBF1 ADCY5 EBF2 MYO3A DLC1

1.26e-0519817377dd874b09c81cc512ccc1e9b65f290a5f94d736e
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT8 KRT14 KRT15 KRT18 ITGB4 RASSF6 MUC4

1.26e-05198173789ec1e760a193441092571475cc66a3b425f232e
ToppCellmLN-(5)_Dendritic_cell-(53)_Lymphoid_DC|mLN / shred on region, Cell_type, and subtype

UBD ANKRD20A2P ANKRD20A3P ANKRD20A4P UPK2 MMP15 ANKRD20A1

1.26e-051981737da84c76afe835aeee39da04b63c03549218b5d91
ToppCellmLN-Dendritic_cell-Lymphoid_DC|mLN / Region, Cell class and subclass

UBD ANKRD20A2P ANKRD20A3P ANKRD20A4P UPK2 MMP15 ANKRD20A1

1.26e-0519817373965a9f1e8a51a196e5349aaca5fa5ed1cd8ee92
ToppCellBAL-Severe-Epithelial-Epithelial-Basal/Club|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KRT8 KRT15 KRT18 EPS8L1 CRACR2B ITGB4 MUC4

1.31e-051991737d04062d86643e5712cc2f519f4f36e643d404a16
ToppCellproximal-Epithelial-Differentiating_Basal-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KRT8 KRT15 KRT18 CRACR2B VILL RASSF6 MUC4

1.31e-051991737c607346f60e5997e757e5a31cab412ab3734377b
ToppCell(5)_Epi_suprabasal|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

KRT8 KRT14 CTNNAL1 KRT15 ITGB4 DST PIK3R1

1.31e-051991737e1d0fd71b2f3925d02638413f2155db009f103d9
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT8 KRT15 KRT18 ITGB4 DST RASSF6 MUC4

1.31e-0519917374099df3c052a9536d72ba01492317be7d83a79ad
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Neuronal-Intermediate|GW10 / Sample Type, Dataset, Time_group, and Cell type.

PPFIA4 OPRK1 PPP2R3A KIAA0825 KCNJ8 PTPRQ WDR89

1.31e-051991737cf592d93612023a13de21e0fb8c6b13714f9af71
ToppCell15-Trachea-Epithelial-Club-like_secretory|Trachea / Age, Tissue, Lineage and Cell class

KRT8 KRT18 ANXA3 EPS8L1 CRACR2B UPK2 MUC4

1.31e-05199173701bc88d9da528e5842b415a32b519b7f53e4cbab
ToppCellSevere_COVID-19-Epithelial-Basal/Club|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

KRT8 KRT15 KRT18 EPS8L1 CRACR2B ITGB4 MUC4

1.31e-0519917372a0aebcfadff4e2dfc8244ad8a87c338ecccacfd
ToppCellBAL-Severe-Epithelial-Epithelial-Basal/Club-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KRT8 KRT15 KRT18 EPS8L1 CRACR2B ITGB4 MUC4

1.31e-051991737fd364f43859b2e7a3e91ce6a1c430cc42ad26a49
ToppCellASK428-Epithelial|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

KRT8 ABCA3 KRT18 ANXA3 LRRK2 DLC1 MRPL14

1.31e-051991737ba2aaaeb4d9b448a6b9660b152fcac1a0e3fcfe7
ToppCellproximal-3-Epithelial-Differentiating_Basal|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KRT8 KRT15 KRT18 CRACR2B VILL RASSF6 MUC4

1.31e-05199173712e07084fc2d5d4c418df564ccc0e132b056e549
ToppCellproximal-Epithelial-Differentiating_Basal|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KRT8 KRT15 KRT18 CRACR2B VILL RASSF6 MUC4

1.31e-05199173796a89a2578fad9a99c52d2cf9e26e06516a96568
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-Basal_3-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KRT8 KRT14 KRT15 KRT18 ITGB4 DST RASSF6

1.35e-05200173741705bbba40eb5ddca0b223191aac1bce00163b8
ComputationalGenes in the cancer module 68.

KRT8 KRT14 KRT15 KRT18

8.66e-0526994MODULE_68
ComputationalKeratin.

KRT8 KRT14 KRT15 KRT18

8.66e-0526994MODULE_298
ComputationalGenes in the cancer module 418.

KRT14 DYNC2H1 INPP5F PACS2 MX2

2.19e-0460995MODULE_418
DrugApomorphine hydrochloride hemihydrate [41372-20-7]; Down 200; 6.4uM; PC3; HG-U133A

CTNNAL1 ST20 GEMIN2 INPP5F ESF1 KIAA0753 ATF6 PTPN11 PTPRA DOP1A

2.39e-06197170101923_DN
Druglight yellow

KRT8 KRT14 KRT18 SIAE MX2

5.11e-06341705CID000221491
DiseaseShort Rib-Polydactyly Syndrome

DYNC2H1 DYNC2I1 NEK1 WDR35

5.88e-07131614C0036996
DiseaseSaldino-Noonan Syndrome

DYNC2H1 DYNC2I1 NEK1 WDR35

8.19e-07141614C0036069
DiseaseMajewski Syndrome

DYNC2H1 DYNC2I1 NEK1 WDR35

8.19e-07141614C0024507
DiseaseEpidermolysis Bullosa Simplex

KRT14 ITGB4 DST

1.58e-0651613C0079298
DiseaseShort rib-polydactyly syndrome, Verma-Naumoff type

DYNC2H1 DYNC2I1 WDR35

1.58e-0651613C0432197
Diseaseasphyxiating thoracic dystrophy (is_implicated_in)

DYNC2H1 KIAA0753 NEK1

5.49e-0671613DOID:0050592 (is_implicated_in)
Diseasebilirubin measurement

MGAT4D KRT8 EBF1 PKD1L2 PGAP6 SLCO1B7 PPP2R3A PTPN11 WDR11 GYS2 USP40 ARMC6

6.13e-0644216112EFO_0004570
DiseaseShort rib-polydactyly syndrome, Majewski type

DYNC2H1 NEK1

2.96e-0521612cv:CN305384
DiseaseCirrhosis, Familial

KRT8 KRT18

2.96e-0521612C1861556
Diseasecomplex cortical dysplasia with other brain malformations 4 (implicated_via_orthology)

TUBG2 TUBG1

2.96e-0521612DOID:0090138 (implicated_via_orthology)
DiseaseEPIDERMOLYSIS BULLOSA SIMPLEX, AUTOSOMAL RECESSIVE (disorder)

KRT14 DST

8.84e-0531612C1832926
DiseaseEpidermolysis Bullosa Herpetiformis Dowling-Meara

KRT14 ITGB4

8.84e-0531612C0079295
DiseaseEpidermolysis Bullosa Simplex Kobner

KRT14 ITGB4

8.84e-0531612C0079299
DiseaseWeber-Cockayne Syndrome

KRT14 ITGB4

8.84e-0531612C0080333
DiseaseProfound Mental Retardation

INPP4A LAMA1 MCC SCN8A CACNA1G ASCC3

1.19e-041391616C0020796
DiseaseMental Retardation, Psychosocial

INPP4A LAMA1 MCC SCN8A CACNA1G ASCC3

1.19e-041391616C0025363
DiseaseMental deficiency

INPP4A LAMA1 MCC SCN8A CACNA1G ASCC3

1.19e-041391616C0917816
Diseaseaspartate aminotransferase measurement

DTD1 PRKD2 KRT8 TTC28 UBD HECTD4 AKNA INPP5F TXK PTPN11 WDR11 PIK3R1 ARHGAP29 MMP15 ARMC6

1.36e-0490416115EFO_0004736
Diseaseserum gamma-glutamyl transferase measurement

KRT8 DOCK11 NUP210L ANXA3 HECTD4 MCC CHD9 EBF1 PGAP6 SLCO1B7 SBNO1 PIK3R1 TLN1 GYS2 MMP15

1.54e-0491416115EFO_0004532
DiseaseEpidermolysis Bullosa

KRT14 ITGB4

1.76e-0441612C0014527
DiseaseIschemic stroke, fibrinogen measurement

HECTD4 CHD9 PPP2R3A GYS2

2.34e-04551614EFO_0004623, HP_0002140
DiseaseBrugada Syndrome (disorder)

AKAP9 KCNJ8 SCN10A

2.97e-04241613C1142166
DiseaseCiliopathies

RPGRIP1L DYNC2H1 BBS1 NEK1 WDR35

3.51e-041101615C4277690
DiseasePolydactyly

RPGRIP1L DYNC2H1 BBS1 DYNC2I1 NEK1

4.66e-041171615C0152427
Diseaseepidermolysis bullosa simplex (is_implicated_in)

KRT14 DST

6.10e-0471612DOID:4644 (is_implicated_in)
DiseaseVentricular Fibrillation

KCNJ8 SCN10A

8.11e-0481612C0042510
Diseasesick sinus syndrome

KRT8 SCN10A

8.11e-0481612MONDO_0001823
Diseasefamilial sick sinus syndrome

KRT8 SCN10A

8.11e-0481612MONDO_0012061
DiseaseIntellectual Disability

KLF8 MAP7D3 INPP4A LAMA1 MCC SCN8A PACS2 CACNA1G ASCC3

8.16e-044471619C3714756
DiseaseMalignant neoplasm of breast

NCOA3 KRT8 ABCA3 KRT14 KRT18 RB1 UBD DYNC2H1 CD109 PER1 CASP7 AKAP9 SBNO1 ARHGAP29 DOP1A

8.30e-04107416115C0006142
DiseaseDisproportionate short stature

DYNC2H1 NEK1 PTPN11 WDR35

8.48e-04771614C0878659
Diseasegestational age

INPP5A EBF1 NAALADL2 ADCY5 DLC1

9.83e-041381615EFO_0005112
Diseaselifestyle measurement, systolic blood pressure

OPRK1 EBF2

1.04e-0391612EFO_0006335, EFO_0010724
Diseasewaist-hip ratio

TTC28 DYNC2H1 HECTD4 MCC EBF1 ZZEF1 CLOCK ADCY5 EBF2 PPP2R3A DLC1 WDR11 DNAH17 KIAA1328 WDR35 ATP2A1

1.14e-03122616116EFO_0004343
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN8A SCN10A

1.29e-03101612DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN8A SCN10A

1.29e-03101612DOID:0080422 (implicated_via_orthology)
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

KRT8 LRRK2 MYO3A MUC4 ALOX5

1.34e-031481615C0279702
Diseaseciliopathy (implicated_via_orthology)

RPGRIP1L KIAA0753 WDR11

1.36e-03401613DOID:0060340 (implicated_via_orthology)
Diseasemean platelet volume

TTC28 DOCK11 NUP210L LRRK2 NUMA1 DYNC2I1 NFASC CHD9 EBF1 TXK MRPL14 ZBED4 GYS2 ANKDD1A

1.46e-03102016114EFO_0004584
DiseaseOther specified cardiac arrhythmias

KCNJ8 SCN10A

1.58e-03111612C0348626
DiseaseJeune thoracic dystrophy

DYNC2H1 DYNC2I1

1.58e-03111612C0265275
DiseaseNodal rhythm disorder

KCNJ8 SCN10A

1.58e-03111612C0264893
DiseaseEctopic rhythm

KCNJ8 SCN10A

1.58e-03111612C1399226
DiseaseShortened QT interval

KCNJ8 SCN10A

1.58e-03111612C0151879
DiseaseCARDIAC CONDUCTION DEFECT, NONSPECIFIC (disorder)

KCNJ8 SCN10A

1.58e-03111612C2748542
Diseaseserum albumin measurement

MCC EBF1 ZZEF1 CLOCK PTPN11 SBNO1 RASSF6 PIK3R1 GAPDHS BSN

1.59e-0359216110EFO_0004535
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN8A SCN10A

1.88e-03121612DOID:0060170 (implicated_via_orthology)
DiseaseAtrial Fibrillation

PPFIA4 PPP2R3A AOPEP KCNJ8 SCN10A

1.89e-031601615C0004238
DiseaseAdenocarcinoma of large intestine

MCC DLC1 PIK3R1 NRK

1.92e-03961614C1319315
Diseaseresponse to angiotensin-converting enzyme inhibitor, Cough

PKD1L2 NAALADL2 GYS2

2.04e-03461613EFO_0005325, HP_0012735
Diseaseglycochenodeoxycholate glucuronide (1) measurement

SLCO1B7 CACNA1G

2.22e-03131612EFO_0800474
DiseaseBrugada Syndrome 1

KCNJ8 SCN10A

2.22e-03131612C4551804
DiseaseMammary Carcinoma, Human

NCOA3 KRT8 KRT14 KRT18 RB1 UBD DYNC2H1 CD109 CASP7

2.46e-035251619C4704874
DiseaseMammary Neoplasms, Human

NCOA3 KRT8 KRT14 KRT18 RB1 UBD DYNC2H1 CD109 CASP7

2.46e-035251619C1257931
DiseaseMammary Neoplasms

NCOA3 KRT8 KRT14 KRT18 RB1 UBD DYNC2H1 CD109 CASP7

2.52e-035271619C1458155
Diseasebody weights and measures, parental genotype effect measurement

EBF1 ADCY5

2.58e-03141612EFO_0004324, EFO_0005939
DiseaseBreast Carcinoma

NCOA3 KRT8 KRT14 KRT18 RB1 UBD DYNC2H1 CD109 CASP7

2.89e-035381619C0678222
DiseaseSinus Node Dysfunction (disorder)

KCNJ8 SCN10A

2.97e-03151612C0428908
DiseaseEarly Pregnancy Loss

IFI35 ITGB4 MMP15 MUC4

3.05e-031091614C3830362
DiseaseSpontaneous abortion

IFI35 ITGB4 MMP15 MUC4

3.05e-031091614C0000786
DiseaseMiscarriage

IFI35 ITGB4 MMP15 MUC4

3.05e-031091614C4552766
DiseaseAbortion, Tubal

IFI35 ITGB4 MMP15 MUC4

3.05e-031091614C0000822
Diseasecreatinine measurement

PRKD2 KLF8 KRT18 INPP4A PPFIA2 CHD9 BTAF1 PTPN9 DLC1 PLXDC2 PIK3R1 ASCC3 BSN

3.27e-0399516113EFO_0004518
DiseaseNeuralgia, Supraorbital

GRM5 SCN10A

3.38e-03161612C0038870
DiseaseNeuralgia

GRM5 SCN10A

3.38e-03161612C0027796
DiseaseRomano-Ward Syndrome

AKAP9 SCN10A

3.38e-03161612C0035828
DiseaseNeuralgia, Atypical

GRM5 SCN10A

3.38e-03161612C0234247
DiseaseNeuralgia, Stump

GRM5 SCN10A

3.38e-03161612C0234249
DiseaseNeuralgia, Iliohypogastric Nerve

GRM5 SCN10A

3.38e-03161612C0423712
DiseaseNeuralgia, Perineal

GRM5 SCN10A

3.38e-03161612C0423711
Diseasephosphatidylcholine 38:6 measurement

AHCTF1 PTPRA

3.38e-03161612EFO_0010388
DiseaseParoxysmal Nerve Pain

GRM5 SCN10A

3.38e-03161612C0751373
DiseaseNerve Pain

GRM5 SCN10A

3.38e-03161612C0751372
DiseaseNeuralgia, Ilioinguinal

GRM5 SCN10A

3.38e-03161612C0751371
DiseaseNeuralgia, Vidian

GRM5 SCN10A

3.38e-03161612C0042656
Diseasecathepsin L1 measurement

LRRK2 PLXDC2

3.38e-03161612EFO_0010619
DiseaseAlcoholic Intoxication, Chronic

MPDZ CLOCK ADCY5 CRHBP OPRK1 PIK3R1

3.62e-032681616C0001973
DiseaseCarcinoma, Granular Cell

NCOA3 KRT8 PTPN11 ALOX5

3.81e-031161614C0205644
DiseaseAdenocarcinoma, Tubular

NCOA3 KRT8 PTPN11 ALOX5

3.81e-031161614C0205645
DiseaseAdenocarcinoma, Oxyphilic

NCOA3 KRT8 PTPN11 ALOX5

3.81e-031161614C0205642
DiseaseCarcinoma, Cribriform

NCOA3 KRT8 PTPN11 ALOX5

3.81e-031161614C0205643
DiseaseAdenocarcinoma, Basal Cell

NCOA3 KRT8 PTPN11 ALOX5

3.81e-031161614C0205641
DiseaseAdenocarcinoma

NCOA3 KRT8 PTPN11 ALOX5

3.81e-031161614C0001418
DiseaseVitiligo

CASP7 PIK3R1

3.81e-03171612C0042900
Diseasebreast carcinoma

PRKD2 MCM8 TTC28 L3MBTL2 CASP7 EBF1 TXK EBF2 PTPN9 AKAP9 WDR11 AOPEP PIK3R1

4.00e-03101916113EFO_0000305
Diseaseportal hypertension (implicated_via_orthology)

PIK3R1 ALOX5

4.76e-03191612DOID:10762 (implicated_via_orthology)
DiseaseSquamous cell carcinoma

NCOA3 KRT14 INPP5A PTPN11

4.82e-031241614C0007137
Diseasereticulocyte count

HECTD4 ST6GAL1 RGS9 EBF1 TRIM10 PTPN11 PTPRA ACSBG1 PIK3R1 DNAH17 FHDC1 BSN ALOX5

4.92e-03104516113EFO_0007986
Diseasereticulocyte measurement

HECTD4 PER1 ST6GAL1 RGS9 EBF1 TRIM10 PTPRA ACSBG1 PIK3R1 DNAH17 FHDC1 BSN ALOX5

5.24e-03105316113EFO_0010700
Diseaseanti-Mullerian hormone measurement

MCM8 TTC28

5.27e-03201612EFO_0004769
DiseaseSarcomatoid Renal Cell Carcinoma

KRT8 LRRK2 MUC4 ALOX5

5.39e-031281614C1266043
DiseaseChromophobe Renal Cell Carcinoma

KRT8 LRRK2 MUC4 ALOX5

5.39e-031281614C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

KRT8 LRRK2 MUC4 ALOX5

5.39e-031281614C1266044
DiseasePapillary Renal Cell Carcinoma

KRT8 LRRK2 MUC4 ALOX5

5.39e-031281614C1306837
DiseaseRenal Cell Carcinoma

KRT8 LRRK2 MUC4 ALOX5

5.39e-031281614C0007134

Protein segments in the cluster

PeptideGeneStartEntry
RTRDVSVQVEMSSAI

ANKRD20A1

636

Q5TYW2
AKVTQTELMRESFRQ

AKAP9

1871

Q99996
RTQDVSVQVEMSSAI

ANKRD20A8P

636

Q5CZ79
RSRVTQMSKKVHTQD

CATSPER1

371

Q8NEC5
EVNITAKVRLTMDRT

BPIFB4

271

P59827
TARVNMTVRQVLATD

ALKBH1

336

Q13686
RTQDVSVQVEMSSAI

ANKRD20A4P

636

Q4UJ75
STQAKMVSKRIAQET

ARMC6

21

Q6NXE6
TIMKRAIFSTQRQSL

GYS2

426

P54840
NKEVSTIQDTRVMTF

ADGRE4P

371

Q86SQ3
TIQDTRVMTFKAISQ

ADGRE4P

376

Q86SQ3
ILTTRTSRQMKDISQ

ANXA3

116

P12429
QMQETHTETKRTTFI

C17orf78

46

Q8N4C9
DMRRFQVVLSTTVNV

EBF2

206

Q9HAK2
KTVTETVRRALVINM

ABCA3

91

Q99758
TATRSRKTAQKTAMQ

DOP1A

661

Q5JWR5
ISVMRAETVIQTVKE

DOP1A

1866

Q5JWR5
RTKEQMDRSSAQVVA

AOPEP

801

Q8N6M6
EVERTKSRRMTNNQQ

ATF6

491

P18850
QTLSRKIVRSKMNST

ADCY5

821

O95622
RTLARNGSTVKMETV

ARMCX4

36

Q5H9R4
TTLVEKMNVFNTDVR

ATP2A1

446

O14983
KFQQKLAEMTSTRTR

RB1

896

P06400
SETKVRVNSNMRTEE

RASSF6

231

Q6ZTQ3
ETGVRMQNQRVLVTS

RGS9

31

O75916
TVSRMRTQRAFSIQT

PTPN9

546

P43378
NTRSVTTMAVINLVV

GPR141

46

Q7Z602
IMDLRNVTFKVTQAT

INPP4A

736

Q96PE3
RRTKTEISEMNRNIS

KRT8

301

P05787
RTRDVSVQVEMSSAI

ANKRD20A2P

636

Q5SQ80
RVDAVAARVQTAVTM

CHMP1B

71

Q7LBR1
VRTLTASENESMRKV

FHDC1

891

Q9C0D6
TAAISRMAQTQRTRT

MUC4

901

Q99102
IQSAMNTSIVRDTKT

DNAJC11

276

Q9NVH1
QKFQERVTITRDMST

IGHV1-58

81

A0A0C4DH39
SMQTIQKTTTRRIVD

KRT18

401

P05783
RNVRSAFTTSTVVRM

GRM5

831

P41594
RKSMIISASVRIQVV

KCNJ8

216

Q15842
VVSRKARIQAATMSD

IGDCC3

126

Q8IVU1
KDTVQQIVSVMSSRR

KIAA0825

911

Q8IV33
SKQQMRSVISVTSAL

NEK1

666

Q96PY6
KQRTISSATVARMNS

MCM8

616

Q9UJA3
STTRTMKSRQAVSRV

RPGRIP1L

31

Q68CZ1
SIVSRMNQATVTSVL

GEMIN2

181

O14893
VVDKSQVSRTRMAVV

L3MBTL2

331

Q969R5
VTSSSRQIRTKVMDV

KRT14

441

P02533
IDRIRASNVASIKTM

DST

986

Q03001
QKFQGRVTMTRDTST

IGHV1-46

81

P01743
ERSLRMTVVKRQAQS

PPFIA4

126

O75335
SRVVVQMEEVARTVN

MMP15

611

P51511
LQTSQSIVRMRQASS

BSN

1261

Q9UPA5
SLHTSRVQRQMVVSV

DYNC2I1

646

Q8WVS4
IECSKTRREMQSVVQ

ESF1

201

Q9H501
QKFQGRVTMTRNTSI

IGHV1-8

81

P0DP01
GITRAVMSKIQVSER

MTG1

181

Q9BT17
SEQSARARTQKELMT

PER1

126

O15534
TMQTVRAADTNEVVK

INPP5A

251

Q14642
VTTIQMSSQLSGRRV

IFI35

121

P80217
ILVTVRNRSSASMAK

OR4K15

221

Q8NH41
SMQVFKQVTASVRNR

KLF8

21

O95600
ATTSARNELIEMKRT

KRT27

296

Q7Z3Y8
LMRVVQSVRHTTRKS

PRKD2

381

Q9BZL6
RVTMITRKEIITQKS

MYOCOS

26

A0A1B0GUC4
ERSLRMTVVKRQAQS

PPFIA1

136

Q13136
KQTNIASTLARMVIR

LRRK2

831

Q5S007
QTSKTEITDLRRTMQ

KRT15

316

P19012
TISLRANKTEMRNET

PGAP6

401

Q9HCN3
FQENSRVIVMTTKEV

PTPN11

346

Q06124
RRSIVRTTSMTRQQN

PACS2

236

Q86VP3
TRTSQEIQMKRTAIE

PIK3R1

471

P27986
DTKVTVMNRVLNATV

HECTD4

3561

Q9Y4D8
LRTEVTSKMFQKTRT

ITGB4

381

P16144
KTIMTERSAAVFIQA

IQCF5

6

A8MTL0
QSRVVRVLSMSRSAI

NDUFA9

6

Q16795
RTLKAVQVQSQSLTM

PPP2R3A

386

Q06190
ARMQEQQVSSRKSTL

KIAA1328

186

Q86T90
VSRMTLSQEKDSVVI

MGAT4D

156

A6NG13
VTAQRQVTVRDKMET

PKD1L2

331

Q7Z442
QVTVRDKMETLSVTA

PKD1L2

336

Q7Z442
IITQYMVTVERNSTK

PTPRQ

1411

Q9UMZ3
EVVVSRMKTVQSVSQ

HFM1

426

A2PYH4
RMKTVQSVSQTLKNT

HFM1

431

A2PYH4
VKMVQVSRDISLTSV

LGALS13

121

Q9UHV8
EVKVRVMNSTAISLQ

NFASC

831

O94856
STRNMVKLAEATRTN

ARHGAP29

236

Q52LW3
NIARSSQRMISSQVI

DYNC2H1

4001

Q8NCM8
MKAVVQRVTRASVTV

DTD1

1

Q8TEA8
RTRDVSVQVEMSSAI

ANKRD20A3P

636

Q5VUR7
TYTKLQNTQVRVMSE

CHD9

496

Q3L8U1
ALMNTERTNIQVTVT

CD109

1196

Q6YHK3
VEEQKEQRMRSLSST

MCC

671

P23508
NVNSTITVTMKVFKR

DOCK11

176

Q5JSL3
QIITSRNKVLATMER

CTNNAL1

166

Q9UBT7
LDSKRQQVQMTVTET

BTAF1

831

O14981
TQFSETKQRESQLMR

CACNA1G

396

O43497
EINTIKMRITRTENE

CCDC175

131

P0C221
VVRMVSSGKHVNRVT

CRHBP

281

P24387
SVSMAIQRISSQLVA

DNAH17

2616

Q9UFH2
TQRDVVAVSRNMQKE

CRACR2B

316

Q8N4Y2
QESRQDMIVRTTQEK

ACSBG1

26

Q96GR2
NSMFQEVRAIVRISK

ADGRF2

636

Q8IZF7
VQAAESVRSTTRQMR

AKNA

1406

Q7Z591
RDMRRFQVVVSTTVN

EBF1

206

Q9UH73
KNVTMRSIKTTRDRV

CASP7

41

P55210
DSVQQSITMVRSKID

MCEMP1

141

Q8IX19
TSIQEVVSRPSSKRM

MAP7D3

821

Q8IWC1
MNVSQVDDVVSSKTR

AHCTF1

1726

Q8WYP5
RDMRRFQVVVSTTVN

EBF3

206

Q9H4W6
QRKRYSTVVMADVSQ

EPS8L1

21

Q8TE68
MSKRDIVLTNVTVVQ

GAPDHS

1

O14556
SNSIKRQTVITTMTT

BBS1

191

Q8NFJ9
VRQLVTSMDVTETNV

SEC24C

931

P53992
FAKIRSSMVQVASIT

INPP5F

1071

Q9Y2H2
SGTNVKMQIVRLRTE

SBNO1

1326

A3KN83
RNQVTEKERRSMITI

LRRC72

171

A6NJI9
QSRKMTTDVASSRLQ

PPFIA2

1231

O75334
VLTSQSEAVVVRAMK

NUP210L

1776

Q5VU65
QNTATIVMVTNLKER

PTPRA

331

P18433
SARRRTTQIINITMT

NUMA1

1806

Q14980
RMERQSTSRVRNTVQ

OPRK1

351

P41145
SVTDVVRMTSNQSLK

NRK

136

Q7Z2Y5
MVKVRRSRNAQVAVT

RPUSD4

231

Q96CM3
KNTMRREVTVELSSQ

DROSHA

831

Q9NRR4
DTTQRNMERTTIKKQ

TMCO5B

221

A8MYB1
VVPDVRSVVTTARMQ

SMARCE1

211

Q969G3
RSVVTTARMQVLKRQ

SMARCE1

216

Q969G3
AIQKMTRVRVVDNSA

MRPL14

31

Q6P1L8
TNSRFVKVVLMSATI

TDRD9

276

Q8NDG6
IFVKISNTISERVMN

ALOX5

211

P09917
MLASTQKVNRATERI

LAMA1

1636

P25391
RMLKRQVSVSISSAV

GPR183

321

P32249
RVTKGMEVVQRISNV

PPWD1

611

Q96BP3
KVVNIDTNSLRSSMR

NCOA3

276

Q9Y6Q9
RVELQMSKITNISAV

PLXDC2

306

Q6UX71
TVTVTLRQGQETIMK

SIAE

56

Q9HAT2
KTTIRLMNSQLVTTE

ST6GAL1

226

P15907
FITSTRQVVRDMKDQ

STX6

91

O43752
MKISTTQIERRFEIS

SLCO1B7

1

G3V0H7
KSRVQQTTVSSRLKM

KIAA0753

531

Q2KHM9
VPMVRKRSVSNSTQT

DLC1

726

Q96QB1
LVSSQKTRVVVTMQH

OXCT2

426

Q9BYC2
RSQLTATSASRVQMI

ANKDD1A

501

Q495B1
NATVRTAMSLIERAK

ASCC3

726

Q8N3C0
EKMVQRRSSFSSQSI

CLOCK

471

O15516
VTSVLGRQTMLTQSV

CILP

16

O75339
TSKQQRSTSIEETMR

C12orf54

16

Q6X4T0
MVVTRSARAKASIQA

DNTTIP2

1

Q5QJE6
ESKMSQSEVARRFQV

TIGD3

26

Q6B0B8
VRRSSSVAQVKAMIE

UBD

106

O15205
TTMATRKVIVTVQAR

VSIG8

131

P0DPA2
STISVTNAQARAMLR

MPDZ

1061

O75970
SVASVRKTTVLDVMR

TUBG1

281

P23258
MARSRLTATSVSQVQ

ST20

1

Q9HBF5
RAQRAMSVVSIITSV

SCN10A

606

Q9Y5Y9
TMVRTAKAIAVTVQE

TLN1

1856

Q9Y490
TDQTLRRIVSQTMKE

PSTK

276

Q8IV42
RINSIMSVVTNTLVE

SCN8A

696

Q9UQD0
KIRITTNDGRQSMVT

VCPIP1

776

Q96JH7
TMEVRINVSRQQVEK

UNC5A

101

Q6ZN44
EMARVVVTVISRKNE

VILL

561

O15195
VQKRQMRTQISLSTD

TXK

21

P42681
SVATKERVMSALTQA

TTC28

1526

Q96AY4
MVRRANDSKVVTSSF

UPK2

61

O00526
MRNVLGSRVTNVKVT

TRAP1

586

Q12931
RENKRMQVLLTQVST

TRIM10

166

Q9UDY6
TESAFQVTQIRIMVR

ZZEF1

576

O43149
SVASVRKTTVLDVMR

TUBG2

281

Q9NRH3
ESMKIASSVHQRVRV

WDR89

361

Q96FK6
QLATREAMARQTVVS

WDR11

631

Q9BZH6
EVQMVSSLRSGRNVT

WDR11

781

Q9BZH6
IEEMINNRNKSVVRS

WDR35

106

Q9P2L0
VKISATVNTMVFDIR

USP40

766

Q9NVE5
ETSRQRKMTQVEQEL

WDR87

1991

Q6ZQQ6
SSSEVEITTMKRAQR

ZBBX

226

A8MT70
NVIQNKTDVRRMSTS

ZRANB3

111

Q5FWF4
TVNLIVSEAIKSQRM

ZBED4

831

O75132
VTMEGSARKVITVRS

VPS13D

3036

Q5THJ4
RGTEKSVMNVVRNLT

MX2

301

P20592
NEIRVVSMQVQTVTK

NAALADL2

411

Q58DX5
ATRHARETTNMKTQT

MYO3A

911

Q8NEV4