Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nuclear retinoic acid receptor binding	PRAMEF14 NSD1 PRAMEF1 PRAMEF2 PRAMEF13	3.44e-06	55	84	5	GO:0042974
GeneOntologyBiologicalProcess	oocyte differentiation	PRAMEF14 ATM PRAMEF1 PRAMEF2 LGR5 PRAMEF13	4.56e-06	103	86	6	GO:0009994
GeneOntologyBiologicalProcess	oogenesis	PRAMEF14 ATM PRAMEF1 PRAMEF2 LGR5 PRAMEF13	4.85e-05	156	86	6	GO:0048477
GeneOntologyBiologicalProcess	oocyte development	PRAMEF14 ATM PRAMEF1 PRAMEF2 PRAMEF13	5.89e-05	99	86	5	GO:0048599
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	PRAMEF14 PRAMEF1 PRAMEF2 PRAMEF13	4.16e-05	47	86	4	GO:0031462
MousePheno	abnormal kidney weight	GAK EFEMP1 CASKIN2 PRAMEF14 PRAMEF1 PRAMEF2 PRAMEF13	4.89e-05	208	65	7	MP:0002707
MousePheno	increased kidney weight	GAK CASKIN2 PRAMEF14 PRAMEF1 PRAMEF2 PRAMEF13	5.61e-05	145	65	6	MP:0003917
MousePheno	abnormal spermatogonia proliferation	PRAMEF14 PRAMEF1 PRAMEF2 PRAMEF13	6.53e-05	47	65	4	MP:0002685
MousePheno	abnormal palate bone morphology	PDS5B GLG1 FOXN3 PDGFC	9.03e-05	51	65	4	MP:0009891
Domain	KRAB	ZNF7 ZNF141 ZNF732 ZNF816 ZNF195 ZNF534 ZNF480 ZNF799 ZNF519 ZNF595 ZNF443	5.18e-07	358	83	11	PS50805
Domain	KRAB	ZNF7 ZNF141 ZNF732 ZNF816 ZNF195 ZNF534 ZNF480 ZNF799 ZNF519 ZNF595 ZNF443	5.18e-07	358	83	11	PF01352
Domain	KRAB	ZNF7 ZNF141 ZNF732 ZNF816 ZNF195 ZNF534 ZNF480 ZNF799 ZNF519 ZNF595 ZNF443	6.98e-07	369	83	11	SM00349
Domain	KRAB	ZNF7 ZNF141 ZNF732 ZNF816 ZNF195 ZNF534 ZNF480 ZNF799 ZNF519 ZNF595 ZNF443	7.17e-07	370	83	11	IPR001909
Domain	RGM_C	RGMA RGMB	5.84e-05	3	83	2	IPR009496
Domain	RGM_N	RGMA RGMB	5.84e-05	3	83	2	IPR010536
Domain	RGM_C	RGMA RGMB	5.84e-05	3	83	2	PF06534
Domain	RGM_N	RGMA RGMB	5.84e-05	3	83	2	PF06535
Domain	PRAME_family	PRAMEF1 PRAMEF2 PRAMEF13	7.79e-05	19	83	3	IPR026271
Domain	zf-C2H2	ZNF7 ZNF141 ZNF732 ZNF816 ZNF195 ZNF534 ZNF480 ZNF799 ZNF519 ZNF595 ZNF443	2.41e-04	693	83	11	PF00096
Domain	zf-C2H2_6	ZNF141 ZNF732 ZNF816 ZNF195 ZNF480 ZNF799 ZNF443	4.94e-04	314	83	7	PF13912
Domain	-	CMIP TLR2 PRAMEF1 PRAMEF2 LGR5 PRAMEF13 LRRC15	5.64e-04	321	83	7	3.80.10.10
Domain	ZINC_FINGER_C2H2_2	ZNF7 ZNF141 ZNF732 ZNF816 ZNF195 ZNF534 ZNF480 ZNF799 ZNF519 ZNF595 ZNF443	6.19e-04	775	83	11	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF7 ZNF141 ZNF732 ZNF816 ZNF195 ZNF534 ZNF480 ZNF799 ZNF519 ZNF595 ZNF443	6.32e-04	777	83	11	PS00028
Domain	L_dom-like	CMIP TLR2 PRAMEF1 PRAMEF2 LGR5 PRAMEF13 LRRC15	6.40e-04	328	83	7	IPR032675
Domain	-	ZNF7 ZNF141 ZNF732 ZNF816 ZNF195 ZNF534 ZNF480 ZNF799 ZNF519 ZNF443	8.39e-04	679	83	10	3.30.160.60
Domain	Znf_C2H2	ZNF7 ZNF141 ZNF732 ZNF816 ZNF195 ZNF534 ZNF480 ZNF799 ZNF519 ZNF595 ZNF443	8.46e-04	805	83	11	IPR007087
Domain	ZnF_C2H2	ZNF7 ZNF141 ZNF732 ZNF816 ZNF195 ZNF534 ZNF480 ZNF799 ZNF519 ZNF595 ZNF443	8.72e-04	808	83	11	SM00355
Domain	Znf_C2H2/integrase_DNA-bd	ZNF7 ZNF141 ZNF732 ZNF816 ZNF195 ZNF534 ZNF480 ZNF799 ZNF519 ZNF443	9.91e-04	694	83	10	IPR013087
Domain	Dynein_heavy_dom-2	DNHD1 DNAH12	1.72e-03	14	83	2	IPR013602
Domain	DHC_N2	DNHD1 DNAH12	1.72e-03	14	83	2	PF08393
Domain	DHC_fam	DNHD1 DNAH12	1.97e-03	15	83	2	IPR026983
Domain	Dynein_heavy_dom	DNHD1 DNAH12	1.97e-03	15	83	2	IPR004273
Domain	Dynein_heavy	DNHD1 DNAH12	1.97e-03	15	83	2	PF03028
Domain	Znf_C2H2-like	ZNF7 ZNF141 ZNF732 ZNF816 ZNF195 ZNF534 ZNF480 ZNF799 ZNF519 ZNF443	2.73e-03	796	83	10	IPR015880
Domain	ARM-type_fold	PDS5B CAND2 NBEAL1 AP3B2 ATM RSPRY1	4.00e-03	339	83	6	IPR016024
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TGM4 NRDE2 CAND2 ATRX ANLN GLG1 PRAMEF14 POLG MYPN NSD1 ALS2 ACCSL PRAMEF1 PRAMEF2 ESPL1 PRAMEF13 ZNF595 TRIM37	1.39e-10	1084	86	18	11544199
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF14 NSD1 PRAMEF1 PRAMEF2 PRAMEF13	2.52e-08	35	86	5	19389355
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF14 PRAMEF1 PRAMEF2 PRAMEF13	1.04e-07	18	86	4	23894331
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF14 PRAMEF1 PRAMEF2 PRAMEF13	1.04e-07	18	86	4	12890732
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF14 PRAMEF1 PRAMEF2 PRAMEF13	1.04e-07	18	86	4	29731491
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF14 PRAMEF1 PRAMEF2 PRAMEF13	1.04e-07	18	86	4	14675769
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF14 PRAMEF1 PRAMEF2 PRAMEF13	1.31e-07	19	86	4	28604677
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF14 PRAMEF1 PRAMEF2 PRAMEF13	1.64e-07	20	86	4	26694250
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF14 PRAMEF1 PRAMEF2 PRAMEF13	1.64e-07	20	86	4	16580637
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF14 PRAMEF1 PRAMEF2 PRAMEF13	1.64e-07	20	86	4	21425410
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF14 PRAMEF1 PRAMEF2 PRAMEF13	2.46e-07	22	86	4	31729367
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF14 PRAMEF1 PRAMEF2 PRAMEF13	2.98e-07	23	86	4	19480014
Pubmed	Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.	PRAMEF14 PRAMEF1 PRAMEF2 PRAMEF13	4.24e-07	25	86	4	12620990
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF14 PRAMEF1 PRAMEF2 PRAMEF13	4.24e-07	25	86	4	37451217
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF14 PRAMEF1 PRAMEF2 PRAMEF13	5.00e-07	26	86	4	18500982
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	TRMT10C GAK CAND2 ATRX CASKIN2 GLG1 OBSL1 EHMT1 TTC17 ATM UPF1 VARS2 ESPL1 TIMM44 TOP2B STT3B	6.57e-07	1487	86	16	33957083
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF14 PRAMEF1 PRAMEF2 PRAMEF13	6.82e-07	28	86	4	25089626
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF14 PRAMEF1 PRAMEF2 PRAMEF13	9.09e-07	30	86	4	38786026
Pubmed	LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.	PRAMEF14 PRAMEF1 PRAMEF2 PRAMEF13	1.19e-06	32	86	4	37889087
Pubmed	Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.	PRAMEF14 PRAMEF1 PRAMEF2 PRAMEF13	5.25e-06	46	86	4	17287250
Pubmed	Bacillus subtilis programs the differentiation of intestinal secretory lineages to inhibit Salmonella infection.	TLR2 LGR5	6.04e-06	2	86	2	36170821
Pubmed	Macrophage proinflammatory response to Francisella tularensis live vaccine strain requires coordination of multiple signaling pathways.	IFNB1 TLR2	6.04e-06	2	86	2	18453609
Pubmed	NAD+ dependent UPRmt activation underlies intestinal aging caused by mitochondrial DNA mutations.	POLG LGR5	6.04e-06	2	86	2	38228611
Pubmed	Loss of ATRX suppresses ATM dependent DNA damage repair by modulating H3K9me3 to enhance temozolomide sensitivity in glioma.	ATRX ATM	6.04e-06	2	86	2	29378238
Pubmed	Effects of maternal lead exposure on RGMa and RGMb expression in the hippocampus and cerebral cortex of mouse pups.	RGMA RGMB	6.04e-06	2	86	2	27545491
Pubmed	Age-associated mitochondrial complex I deficiency is linked to increased stem cell proliferation rates in the mouse colon.	POLG LGR5	6.04e-06	2	86	2	33626245
Pubmed	Potential prognostic value of repulsive guidance molecules in breast cancer.	RGMA RGMB	6.04e-06	2	86	2	21617229
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF7 EHMT1 ZNF195 ZNF480 ZNF799 ZNF595	6.09e-06	181	86	6	37372979
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	PRAMEF14 PRAMEF1 PRAMEF2 PRAMEF13	7.36e-06	50	86	4	31806660
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF1 PRAMEF2 PRAMEF13	9.68e-06	17	86	3	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF1 PRAMEF2 PRAMEF13	9.68e-06	17	86	3	37781892
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF1 PRAMEF2 PRAMEF13	1.16e-05	18	86	3	39181896
Pubmed	Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.	ZNF7 ZNF195 ZNF595	1.61e-05	20	86	3	7479878
Pubmed	Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.	ZNF7 ZNF195 ZNF595	1.61e-05	20	86	3	2542606
Pubmed	Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci.	ZNF7 EPOR ZNF195 ZNF595	1.63e-05	61	86	4	8662221
Pubmed	Repulsive guidance molecules, novel bone morphogenetic protein co-receptors, are key regulators of the growth and aggressiveness of prostate cancer cells.	RGMA RGMB	1.81e-05	3	86	2	22076499
Pubmed	Phagosomal signaling by Borrelia burgdorferi in human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-beta.	IFNB1 TLR2	1.81e-05	3	86	2	21321205
Pubmed	Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice.	EPOR POLG	1.81e-05	3	86	2	25411424
Pubmed	Supervillin binding to myosin II and synergism with anillin are required for cytokinesis.	ANLN SVIL	1.81e-05	3	86	2	24088567
Pubmed	Molecular basis of functional exchangeability between ezrin and other actin-membrane associated proteins during cytokinesis.	ANLN SVIL	1.81e-05	3	86	2	33862101
Pubmed	Type I interferons promote severe disease in a mouse model of lethal ehrlichiosis.	IFNB1 TLR2	1.81e-05	3	86	2	24491580
Pubmed	TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: a critical role of IFN-beta as a decision maker.	IFNB1 TLR2	1.81e-05	3	86	2	15879150
Pubmed	Expression pattern of the repulsive guidance molecules RGM A, B and C during mouse development.	RGMA RGMB	1.81e-05	3	86	2	15053976
Pubmed	Both TLR2 and TRIF contribute to interferon-β production during Listeria infection.	IFNB1 TLR2	3.61e-05	4	86	2	22432012
Pubmed	Elevated HMGN4 expression potentiates thyroid tumorigenesis.	ATRX ATM	3.61e-05	4	86	2	28186538
Pubmed	The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells.	ATM UPF1	3.61e-05	4	86	2	15175154
Pubmed	DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties.	RGMA RGMB	3.61e-05	4	86	2	14985445
Pubmed	Gene expression of the repulsive guidance molecules/neogenin in the developing and mature mouse visual system: C57BL/6J vs. the glaucoma model DBA/2J.	RGMA RGMB	3.61e-05	4	86	2	17942375
Pubmed	ATM binds to beta-adaptin in cytoplasmic vesicles.	AP3B2 ATM	3.61e-05	4	86	2	9707615
Pubmed	Isolation and expression pattern of three mouse homologues of chick Rgm.	RGMA RGMB	6.01e-05	5	86	2	14678836
Pubmed	Cell based assay identifies TLR2 and TLR4 stimulating impurities in Interferon beta.	IFNB1 TLR2	6.01e-05	5	86	2	28874687
Pubmed	Specific engagement of TLR4 or TLR3 does not lead to IFN-beta-mediated innate signal amplification and STAT1 phosphorylation in resident murine alveolar macrophages.	IFNB1 TLR2	6.01e-05	5	86	2	15240691
Pubmed	Gene expression of the repulsive guidance molecules during development of the mouse intestine.	RGMA RGMB	6.01e-05	5	86	2	16032658
Pubmed	ASB16-AS1 up-regulated and phosphorylated TRIM37 to activate NF-κB pathway and promote proliferation, stemness, and cisplatin resistance of gastric cancer.	ATM TRIM37	6.01e-05	5	86	2	32572790
Pubmed	Reprogramming of murine macrophages through TLR2 confers viral resistance via TRAF3-mediated, enhanced interferon production.	IFNB1 TLR2	6.01e-05	5	86	2	23853595
Pubmed	Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1.	ATM UPF1	6.01e-05	5	86	2	16086026
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	PDS5B CAND2 ANLN AHCY EHMT1 ZNF195 UPF1 TIMM44 TOP2B	6.22e-05	704	86	9	29955894
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	NRDE2 GAK NCALD ATRX ANLN EML4 AHCY OBSL1 ESPL1 STT3B	8.42e-05	910	86	10	36736316
Pubmed	Cys2His2 zinc finger protein family: classification, functions, and major members.	ZNF732 ZNF595	9.01e-05	6	86	2	22803940
Pubmed	SCFβ-TrCP-mediated degradation of TOP2β promotes cancer cell survival in response to chemotherapeutic drugs targeting topoisomerase II.	ATM TOP2B	9.01e-05	6	86	2	32015321
Pubmed	Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.	RGMA RGMB	9.01e-05	6	86	2	33740419
Pubmed	Human INT6/eIF3e is required for nonsense-mediated mRNA decay.	EIF3A UPF1	9.01e-05	6	86	2	17468741
Pubmed	Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein.	RGMA RGMB	9.01e-05	6	86	2	25938661
Pubmed	Chlamydia trachomatis induces expression of IFN-gamma-inducible protein 10 and IFN-beta independent of TLR2 and TLR4, but largely dependent on MyD88.	IFNB1 TLR2	9.01e-05	6	86	2	15972679
Pubmed	Transient receptor potential channels and their role in modulating radial glial-neuronal interaction: a signaling pathway involving mGluR5.	TRPC3 GRM5	9.01e-05	6	86	2	25347706
Pubmed	Repulsive guidance molecule (RGM) gene function is required for neural tube closure but not retinal topography in the mouse visual system.	RGMA RGMB	1.26e-04	7	86	2	14749425
Pubmed	DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity.	IFNB1 ATM	1.26e-04	7	86	2	25692705
Pubmed	IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment.	IL17RE LGR5	1.26e-04	7	86	2	35081371
Pubmed	Variants in several genomic regions associated with asperger disorder.	RGMB NTM	1.26e-04	7	86	2	21182207
Pubmed	Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.	PRAMEF14 EHMT1 ALS2 PRAMEF1 PRAMEF2 PRAMEF13	1.62e-04	326	86	6	17015433
Pubmed	TGFβ Induces a SAMHD1-Independent Post-Entry Restriction to HIV-1 Infection of Human Epithelial Langerhans Cells.	IFNB1 TLR2	1.68e-04	8	86	2	27375111
Pubmed	MyD88 and STING signaling pathways are required for IRF3-mediated IFN-β induction in response to Brucella abortus infection.	IFNB1 TLR2	1.68e-04	8	86	2	21829705
Pubmed	Murine toll-like receptor 2 activation induces type I interferon responses from endolysosomal compartments.	IFNB1 TLR2	1.68e-04	8	86	2	20422028
Pubmed	Identification of potential nuclear reprogramming and differentiation factors by a novel selection method for cloning chromatin-binding proteins.	ATRX NSD1	1.68e-04	8	86	2	15522233
Pubmed	TLR agonists induce regulatory dendritic cells to recruit Th1 cells via preferential IP-10 secretion and inhibit Th1 proliferation.	IFNB1 TLR2	1.68e-04	8	86	2	17170125
Pubmed	Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα.	LGR5 PCK1	1.68e-04	8	86	2	34857752
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	DNHD1 PDS5B TRMT10C ATRX AHCY EHMT1 EIF3A ATM UPF1 TIMM44 TOP2B STT3B	1.98e-04	1425	86	12	30948266
Pubmed	Substrate specificity analysis and novel substrates of the protein lysine methyltransferase NSD1.	ATRX NSD1	2.15e-04	9	86	2	24412544
Pubmed	Spatiotemporal expression of repulsive guidance molecules (RGMs) and their receptor neogenin in the mouse brain.	RGMA RGMB	2.15e-04	9	86	2	23457482
Pubmed	Role of Gadd45a in Wip1-dependent regulation of intestinal tumorigenesis.	ATM LGR5	2.15e-04	9	86	2	22555459
Pubmed	The human RNA surveillance factor UPF1 is required for S phase progression and genome stability.	POLG UPF1	2.15e-04	9	86	2	16488880
Pubmed	A Map of Toll-like Receptor Expression in the Intestinal Epithelium Reveals Distinct Spatial, Cell Type-Specific, and Temporal Patterns.	TLR2 LGR5	2.15e-04	9	86	2	30170812
Pubmed	Comparative analysis of KRAB zinc finger proteins in rodents and man: evidence for several evolutionarily distinct subfamilies of KRAB zinc finger genes.	ZNF195 ZNF595	2.15e-04	9	86	2	10360839
Pubmed	Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint.	EPOR GAK CMIP RSPRY1	2.37e-04	121	86	4	26354767
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	ATRX PRAMEF14 MYPN TLR2 ACCSL PRAMEF1 PRAMEF2 PRAMEF13	2.68e-04	674	86	8	37196079
Pubmed	Interferon b drives intestinal regeneration after radiation.	IFNB1 LGR5	2.68e-04	10	86	2	34613772
Pubmed	Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay.	EIF3A UPF1	2.68e-04	10	86	2	18423202
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	NRDE2 PRAMEF14 ALS2 PRAMEF1 PRAMEF2 PRAMEF13	2.89e-04	363	86	6	14691545
Pubmed	Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN.	IFNB1 TLR2	3.28e-04	11	86	2	31293597
Pubmed	Conventional dendritic cells mount a type I IFN response against Candida spp. requiring novel phagosomal TLR7-mediated IFN-β signaling.	IFNB1 TLR2	3.28e-04	11	86	2	21282509
Pubmed	A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.	FOXN3 PDGFC SFMBT2	3.49e-04	55	86	3	22581228
Pubmed	ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.	PRAMEF1 PRAMEF2 PRAMEF13	4.08e-04	58	86	3	31598710
Pubmed	An abundance of X-linked genes expressed in spermatogonia.	PRAMEF1 PRAMEF2 PRAMEF13	4.29e-04	59	86	3	11279525
Pubmed	Dysregulated Lung Commensal Bacteria Drive Interleukin-17B Production to Promote Pulmonary Fibrosis through Their Outer Membrane Vesicles.	IL17RE TLR2	4.63e-04	13	86	2	30824326
Pubmed	An ATM/TRIM37/NEMO Axis Counteracts Genotoxicity by Activating Nuclear-to-Cytoplasmic NF-κB Signaling.	ATM TRIM37	4.63e-04	13	86	2	30254148
Pubmed	A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2.	NBEAL1 ALS2	4.63e-04	13	86	2	11586298
Pubmed	DEC1 represses cardiomyocyte hypertrophy by recruiting PRP19 as an E3 ligase to promote ubiquitination-proteasome-mediated degradation of GATA4.	EML4 UPF1	4.63e-04	13	86	2	35659652
Pubmed	MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates.	ZNF7 TOP2B	4.63e-04	13	86	2	9155018
Pubmed	RGMB and neogenin control cell differentiation in the developing olfactory epithelium.	RGMA RGMB	4.63e-04	13	86	2	27143755
Pubmed	Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development.	ANLN ATM ESPL1	4.74e-04	61	86	3	27694478
Interaction	TRIM28 interactions	ZNF7 PDS5B CAND2 ATRX ZNF732 ANLN AHCY OBSL1 EHMT1 ZNF816 ZNF195 ZNF480 ZNF799 ATM UPF1 TIMM44 ZNF595 ZNF443 TOP2B	5.39e-06	1474	82	19	int:TRIM28
Cytoband	1p36.21	PRAMEF14 PRAMEF1 PRAMEF2 PRAMEF13	6.28e-06	63	86	4	1p36.21
Cytoband	4q32	TLR2 PDGFC	5.18e-05	6	86	2	4q32
Cytoband	19p13.3-p13.2	EPOR TIMM44	3.11e-04	14	86	2	19p13.3-p13.2
Cytoband	19q13.41	ZNF816 ZNF534 ZNF480	4.36e-04	78	86	3	19q13.41
Cytoband	4p16.3	ZNF141 ZNF732 ZNF595	5.61e-04	85	86	3	4p16.3
Cytoband	Ensembl 112 genes in cytogenetic band chr4p16	GAK ZNF141 ZNF732 ZNF595	8.29e-04	222	86	4	chr4p16
GeneFamily	PRAME family	PRAMEF14 PRAMEF1 PRAMEF2 PRAMEF13	1.03e-06	24	59	4	686
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF7 ZNF141 ZNF732 ZNF816 ZNF195 ZNF534 ZNF480 ZNF799 ZNF519 ZNF595 ZNF443	1.76e-05	718	59	11	28
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	FLT1 NTM MYPN OBSL1	1.88e-03	161	59	4	593
Coexpression	BYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_TRANS	PRAMEF14 AHCY NSD1 TTC17 PRAMEF1 PRAMEF2 PRAMEF13	2.18e-06	180	86	7	MM612
Coexpression	KUMAR_TARGETS_OF_MLL_AF9_FUSION	IFNB1 GLG1 PRAMEF14 ATM PRAMEF1 PRAMEF2 LGR5 PRAMEF13 SFMBT2	2.14e-05	463	86	9	MM1011
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ILDR2 EFEMP1 ANLN IL17RE NTM SFMBT2	1.27e-06	178	86	6	c77a1d1a9aef0ab51b4408b9e84f201219788ca2
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL3A1 ILDR2 NRDE2 EFEMP1 IL17RE SFMBT2	1.40e-06	181	86	6	330d4322f4c4373f706273c1f4e218b59051b7fd
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL3A1 ILDR2 NRDE2 EFEMP1 IL17RE SFMBT2	1.40e-06	181	86	6	3f4d5d79c1286614514b0e8134079d6128a2a23e
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL3A1 NCALD EFEMP1 NTM SVIL MYPN	1.98e-06	192	86	6	20ede290e01ad574afd122d72b59dbc52c595fad
ToppCell	facs-Aorta-Heart-3m\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CMIP BNIP2 ATRX GLG1 EIF3A TOP2B	1.98e-06	192	86	6	1ccc47792edf9ee23501c8e2165d11271636b66a
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Stem_cells-stem_cells_1\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	NRDE2 IL17RE UPF1 ZNF519 PCK1	1.15e-05	152	86	5	375c9ef88c7703a002e868645a722c35e046ef1e
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL3A1 NTM SVIL PDGFC LRRC15	1.47e-05	160	86	5	8624f101828efd32cdd38a65df8d94d690720a63
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL3A1 NTM SVIL PDGFC LRRC15	1.47e-05	160	86	5	9de3dd6b9d4b51314d60b3b01f4132bcfa2dfc18
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_A2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TLR2 OBSL1 SERINC2 ESPL1 SFMBT2	1.52e-05	161	86	5	8ec923c230a7a3cce5edf2a736b3a00d607c698a
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ILDR2 ANLN AP3B2 TM4SF4 VARS2	1.92e-05	169	86	5	96a2aec9acf8a6f966973c035e5ade456cf47772
ToppCell	droplet-Kidney-KIDNEY-1m-Myeloid-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDS5B ANLN TLR2 ALS2 ESPL1	2.03e-05	171	86	5	d9ad6a3bce3556abd24af1630bf4a99594437c3a
ToppCell	droplet-Fat-Scat-21m-Endothelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGM4 FLT1 CASKIN2 NBEAL1 PCK1	2.15e-05	173	86	5	f13124b4cf2ac1dc2895f90f5487d6ac681b0ba4
ToppCell	10x5'v1-week_12-13-Lymphocytic_NK-T_NK-ILC_precursor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ILDR2 RGMB NCALD IL17RE NTM	2.53e-05	179	86	5	bc95c3e7edc5fc6fc913b09f087d221df64c6f48
ToppCell	droplet-Marrow-nan-3m-Hematologic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATRX EML4 NSD1 TESPA1 TOP2B	2.74e-05	182	86	5	e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCell	droplet-Marrow-nan-3m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATRX EML4 NSD1 TESPA1 TOP2B	2.74e-05	182	86	5	1710eab3037a87609d21838be2d2d29c3bc36651
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATRX EML4 NSD1 EIF3A TOP2B	2.89e-05	184	86	5	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL3A1 RGMA RNF150 CMIP SVIL	3.20e-05	188	86	5	879de94924de978478696fc7838e05a4d795b905
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-myocytic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL3A1 RGMA RNF150 CMIP SVIL	3.28e-05	189	86	5	ab7ece0a517499b70b7754720d3e434765363af6
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CMIP ATRX NBEAL1 EML4 TOP2B	3.45e-05	191	86	5	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ILDR2 FLT1 NCALD CASKIN2 LGR5	3.45e-05	191	86	5	f229abf69a1217194f74b0502486907e07dba989
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CMIP ATRX NBEAL1 EML4 TOP2B	3.45e-05	191	86	5	09db184cb90fe282a14474d7217068c58092c6f8
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CMIP ATRX NBEAL1 EML4 TOP2B	3.45e-05	191	86	5	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	droplet-Limb_Muscle-MUSCLE\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 FLT1 ATRX NSD1 FOXN3	3.71e-05	194	86	5	e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCell	droplet-Marrow-nan-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDS5B ATRX EML4 LGR5 TOP2B	3.71e-05	194	86	5	8ef0b71fef5b84cfd04973f891215333e7035d1d
ToppCell	(1)_Osterolineage_cells-(11)_OLC-2\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	COL3A1 RGMB PDGFC LGR5 LRRC15	3.81e-05	195	86	5	78978d85273e5463a7f43e4c121e647fa6aba42b
ToppCell	Sepsis-ICU-SEP-Myeloid-cDC1\|ICU-SEP / Disease, condition lineage and cell class	ILDR2 NCALD AHCY OBSL1 TSSK4	4.00e-05	197	86	5	e3174e90ea6136f1aa3a4a185b86458e35d51fd4
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-Myofibroblasts\|Fibroblasts / Location, Cell class and cell subclass	COL3A1 NTM SVIL PDGFC LRRC15	4.29e-05	200	86	5	eabb7d4aa92ace7d970bcd3fae2c7cb5400a43b4
ToppCell	LPS_IL1RA\|World / Treatment groups by lineage, cell group, cell type	FLT1 CMIP SVIL EIF3A LRRC15	4.29e-05	200	86	5	a02fa5b3c4723a6eaa3c685588666c710478dd25
Disease	tumor necrosis factor-alpha measurement, chronic obstructive pulmonary disease	RNF150 NTM	7.40e-05	5	81	2	EFO_0000341, EFO_0004684
Disease	mortality	GAK POP4 POLG SVIL SFMBT2	1.17e-04	173	81	5	EFO_0004352
Disease	Adenoid Cystic Carcinoma	ATRX NSD1 ATM ESPL1	1.69e-04	100	81	4	C0010606
Disease	retinopathy of prematurity (biomarker_via_orthology)	EPOR FLT1	4.83e-04	12	81	2	DOID:13025 (biomarker_via_orthology)
Disease	chronic obstructive pulmonary disease	FLT1 NCALD EML4 NTM SVIL MYPN VARS2 TOP2B	6.04e-04	688	81	8	EFO_0000341
Disease	Kuhnt-Junius degeneration (is_marker_for)	FLT1 TLR2	6.63e-04	14	81	2	DOID:10873 (is_marker_for)
Disease	proliferative diabetic retinopathy (is_marker_for)	FLT1 TIMM44	8.71e-04	16	81	2	DOID:13207 (is_marker_for)
Disease	filaggrin gene expression measurement	RNF150 NTM	8.71e-04	16	81	2	EFO_0020899
Disease	Hepatitis	PDS5B NTM	1.66e-03	22	81	2	HP_0012115
Disease	S-6-hydroxywarfarin to S-warfarin ratio measurement	RNF150 MYPN PCK1	1.85e-03	88	81	3	EFO_0803332
Disease	FEV/FEC ratio	FLT1 NCALD EFEMP1 DNAH12 EML4 NTM SVIL NSD1 MEAK7 TOP2B	1.93e-03	1228	81	10	EFO_0004713
Disease	pseudotumor cerebri	RGMA FOXN3	2.32e-03	26	81	2	EFO_1001132
Disease	Adenocarcinoma of lung (disorder)	FLT1 EML4 AHCY ATM	2.52e-03	206	81	4	C0152013
Disease	Pancreatic Neoplasm	EFEMP1 ATRX ATM	2.66e-03	100	81	3	C0030297
Disease	prostate carcinoma in situ (is_marker_for)	FLT1 ATM	2.69e-03	28	81	2	DOID:8634 (is_marker_for)
Disease	lung small cell carcinoma (is_implicated_in)	ATRX ATM	2.69e-03	28	81	2	DOID:5409 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
CIEDTLLQYPDWRGQ	ACCSL	196	Q4AC99
LPQGQYLREGECWLD	ADGRF3	906	Q8IZF5
EDIYWECVLRLNKQP	ALS2	1501	Q96Q42
LQEIWPGCEIRYLEG	ABHD18	386	Q0P651
DVQLLSWENAPKYCL	CMIP	116	Q8IY22
RPQCKLNQEAWYILA	ADRA2B	161	P18089
EQWRIGLCYLQSPDL	FAM187A	186	A6NFU0
SWLPQELDRCYELLD	DNHD1	421	Q96M86
DDCYLTNRLWQDLKP	C5orf38	76	Q86SI9
YRKLCNLLIDVEEWG	AP3B2	221	Q13367
KAIQLYLTCERGPWA	NBEAL1	1776	Q6ZS30
ELASQNKPLWQCYLG	PDS5B	306	Q9NTI5
RECLNIDIPEGNWYC	NSD1	1731	Q96L73
KYDNCWLALTDPRDV	PCK1	71	P35558
DLEDLYRPTWQLLGK	PDGFC	211	Q9NRA1
WLREGAELCPGDKYE	OBSL1	1841	O75147
VDWGDLNLVLPCLEY	KIAA0100	2136	Q14667
DLTGCDLIPVQYLRW	GRM5	561	P41594
YAGNDKWCLDPRVVL	NTM	76	Q9P121
LVDIRLWQPDACYKP	ANLN	1106	Q9NQW6
GWYVLEKVDLHPQLC	IL17RE	326	Q8NFR9
LQNCPWAKVLYLDAV	NRDE2	1116	Q9H7Z3
WLNSLKGPLCEPEYQ	DNAH12	1691	Q6ZR08
CQLLSGERYKEDPWL	POLG	471	P54098
LLGPQWLDYDCDRAV	MEAK7	181	Q6P9B6
TDLLEWLCALGLPQY	CASKIN2	561	Q8WXE0
DEICLRYKGDLAPLW	UPF1	371	Q92900
GEKQDIWALGCILYL	GAK	241	O14976
DWKLDPVLYRKCQGD	GLG1	556	Q92896
LKGLDYENKDWCPEL	ATM	2081	Q13315
PWCLQLDYISKENKG	ATRX	1886	P46100
RLQELLQDCGWKYPD	ESPL1	1821	Q14674
LQDCGWKYPDRTLLK	ESPL1	1826	Q14674
YNWLEVEFNPLKLCE	EIF3A	391	Q14152
GSLWCIDPEYRQNLI	FOXN3	186	O00409
LLWQLNGRLEYCLKD	IFNB1	41	P01574
PSLGWLRKCYQQIDR	BNIP2	221	Q12982
YQLEDEPWKLCRLHQ	EPOR	81	P19235
EYWVDPNQGCKLDAI	COL3A1	1276	P02461
LYWDIPNGCKLIRNR	EML4	746	Q9HC35
LCGKNWERLENLYDA	DHRS7C	66	A6NNS2
KPYAEDIWALLFQRC	CAND2	931	O75155
LWCIEQTLYFKDGPL	AHCY	111	P23526
RCWYDKDGRLLPEFN	EHMT1	1081	Q9H9B1
EIQEWYKGFLRDCPS	NCALD	26	P61601
KLYCNLDKGDLENIW	LGR5	746	O75473
KEIPQDECLRYLFQW	PRAMEF13	156	Q5VWM6
NWIALIPKGNCTYRD	RNF150	116	Q9ULK6
DGYEWDPVRQQCKDI	EFEMP1	31	Q12805
NLCDVYLEAVKPVLW	VARS2	816	Q5ST30
CKVEGAWPLIDNNYL	RGMB	181	Q6NW40
LQVSGLCWRLKVYPD	TRIM37	301	O94972
PRGQCLLYNWEEERA	SPAG8	276	Q99932
DPDYLKRQVGFCAQW	RSPRY1	281	Q96DX4
ARYWPGQRIKADCQL	SSPOP	1876	A2VEC9
WACKLPNYDAREIVN	TOP2B	881	Q02880
DDDYWGKIPKCSLLQ	SVIL	1576	O95425
HLGKLCELRLYDNPW	LRRC15	411	Q8TF66
KEIPQDECLRYLFQW	PRAMEF14	156	Q5SWL7
WKQYIRDLCSGLKPD	POP4	106	O95707
KEIPQDECLRYLFQW	PRAMEF1	156	O95521
ENILYLLFNPWCKED	TGM4	131	P49221
KEIPQDECLRYLFQW	PRAMEF2	156	O60811
CKVQGAWPLIDNNYL	RGMA	181	Q96B86
EEWKCLDPAQQNLYR	ZNF595	16	Q8IYB9
LEWIQRYGACSEPLA	TSSK4	111	Q6SA08
EEWKCLDPAQQNLYR	ZNF519	16	Q8TB69
SKRNLEWDPYLDCLD	ILDR2	81	Q71H61
PAGLWFCIKNINDER	STT3B	426	Q8TCJ2
LDYRLRPVGWCQENK	SFMBT2	236	Q5VUG0
EEWALLGPCQKNLYK	ZNF799	16	Q96GE5
EWKCLDPGQKALYRD	ZNF534	21	Q76KX8
KRDYQRLGWPSPDEC	TTC17	891	Q96AE7
EEWKCLDPDQQNLYR	ZNF141	16	Q15928
WKCLDPAQRALYKDV	ZNF480	41	Q8WV37
CRDQDELNPYAAWRL	TIMM44	426	O43615
EEWALLGPCQKNLYK	ZNF443	16	Q9Y2A4
NPINKIEDWLQDCGY	TESPA1	56	A2RU30
EEWKCLDPAQQNLYR	ZNF732	16	B4DXR9
LDEQCERLPYDASKW	FLT1	806	P17948
LAKVLIDWPANYLCD	TLR2	551	O60603
LATECLPLDKYLQWE	TRMT10C	331	Q7L0Y3
YLNDEALWNKCREPL	TM4SF4	136	P48230
VESQLYKLPWVCEEG	SERINC2	61	Q96SA4
GNCGLDNLYLRKDWE	ZNF195	176	O14628
EEWKCLNPAQRALYR	ZNF816	36	Q0VGE8
EEWQCLDPGQRALYR	ZNF7	16	P17097
CKELWLEGPREYILQ	TRPC3	441	Q13507
RWYCEGKELENSPDI	MYPN	301	Q86TC9