Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	SHPRH CHD8 CHD7	1.44e-04	37	55	3	GO:0140658
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase III	SF3B1 MTOR RPTOR CHD8	2.12e-07	20	55	4	GO:0045945
GeneOntologyBiologicalProcess	regulation of transcription by RNA polymerase III	SF3B1 MTOR RPTOR CHD8	1.54e-06	32	55	4	GO:0006359
GeneOntologyBiologicalProcess	in utero embryonic development	SF3B1 SPEG CHD8 CHD7 PCDH12 NMT1 HECTD1 UTY VCAM1 PPP4R4	3.41e-06	596	55	10	GO:0001701
GeneOntologyBiologicalProcess	chordate embryonic development	SFRP1 SF3B1 SPEG POLR1B CHD8 CHD7 PCDH12 NMT1 HECTD1 UTY VCAM1 PPP4R4	3.67e-06	906	55	12	GO:0043009
GeneOntologyBiologicalProcess	embryo development ending in birth or egg hatching	SFRP1 SF3B1 SPEG POLR1B CHD8 CHD7 PCDH12 NMT1 HECTD1 UTY VCAM1 PPP4R4	4.75e-06	929	55	12	GO:0009792
GeneOntologyBiologicalProcess	peptidyl-threonine phosphorylation	ADCY10 HIPK4 MTOR RPTOR EIF4G1	1.37e-05	115	55	5	GO:0018107
GeneOntologyBiologicalProcess	peptidyl-threonine modification	ADCY10 HIPK4 MTOR RPTOR EIF4G1	2.06e-05	125	55	5	GO:0018210
GeneOntologyBiologicalProcess	transcription by RNA polymerase III	SF3B1 MTOR RPTOR CHD8	2.40e-05	63	55	4	GO:0006383
GeneOntologyBiologicalProcess	positive regulation of cell differentiation	ADCY10 SFRP1 MTOR IL20 RPTOR CIP2A SOCS5 EIF4G1 BRINP1 SUCO IL4R MFN1	3.72e-05	1141	55	12	GO:0045597
GeneOntologyBiologicalProcess	positive regulation of pentose-phosphate shunt	MTOR RPTOR	4.17e-05	4	55	2	GO:1905857
GeneOntologyBiologicalProcess	social behavior	MTOR RPTOR CHD8 BRINP1	4.53e-05	74	55	4	GO:0035176
GeneOntologyBiologicalProcess	biological process involved in intraspecies interaction between organisms	MTOR RPTOR CHD8 BRINP1	5.03e-05	76	55	4	GO:0051703
GeneOntologyBiologicalProcess	T-helper 1 cell differentiation	MTOR SOCS5 IL4R	6.24e-05	29	55	3	GO:0045063
GeneOntologyBiologicalProcess	regulation of cell development	ADCY10 SFRP1 MTOR IL20 RPTOR CIP2A SOCS5 BRINP1 CHD7 IL4R MFN1	1.25e-04	1095	55	11	GO:0060284
GeneOntologyBiologicalProcess	regulation of pentose-phosphate shunt	MTOR RPTOR	1.45e-04	7	55	2	GO:0043456
GeneOntologyBiologicalProcess	positive regulation of cell development	ADCY10 MTOR IL20 RPTOR CIP2A SOCS5 IL4R MFN1	2.09e-04	614	55	8	GO:0010720
GeneOntologyBiologicalProcess	leukocyte differentiation	SFRP1 MTOR IL20 RPTOR SOCS5 CHD7 HECTD1 IL4R VCAM1	2.20e-04	789	55	9	GO:0002521
GeneOntologyBiologicalProcess	peptidyl-amino acid modification	ADCY10 SFRP1 HIPK4 MTOR IL20 RPTOR SOCS5 EIF4G1 OGFOD1 NMT1	2.26e-04	976	55	10	GO:0018193
GeneOntologyBiologicalProcess	cytoplasmic translational initiation	MTOR EIF4G1 EIF3A	2.35e-04	45	55	3	GO:0002183
GeneOntologyBiologicalProcess	positive regulation of cell growth	ADCY10 SFRP1 MTOR RPTOR EIF4G1	2.56e-04	213	55	5	GO:0030307
GeneOntologyBiologicalProcess	regulation of osteoclast differentiation	SFRP1 MTOR IL20 RPTOR	2.60e-04	116	55	4	GO:0045670
GeneOntologyBiologicalProcess	positive regulation of growth	ADCY10 SFRP1 MTOR RPTOR EIF4G1 CHD7	2.77e-04	339	55	6	GO:0045927
GeneOntologyBiologicalProcess	positive regulation of ATP metabolic process	ADCY10 MTOR RPTOR	2.85e-04	48	55	3	GO:1903580
GeneOntologyBiologicalProcess	regulation of NADP metabolic process	MTOR RPTOR	3.10e-04	10	55	2	GO:1902031
GeneOntologyBiologicalProcess	negative regulation of fibroblast apoptotic process	SFRP1 CHD8	3.10e-04	10	55	2	GO:2000270
GeneOntologyBiologicalProcess	embryo development	SFRP1 SF3B1 SPEG POLR1B CHD8 CHD7 PCDH12 NMT1 HECTD1 UTY VCAM1 PPP4R4	3.31e-04	1437	55	12	GO:0009790
GeneOntologyBiologicalProcess	regulation of peptidyl-threonine phosphorylation	ADCY10 RPTOR EIF4G1	3.61e-04	52	55	3	GO:0010799
GeneOntologyBiologicalProcess	positive regulation of nucleotide metabolic process	ADCY10 MTOR RPTOR	4.27e-04	55	55	3	GO:0045981
GeneOntologyBiologicalProcess	positive regulation of purine nucleotide metabolic process	ADCY10 MTOR RPTOR	4.27e-04	55	55	3	GO:1900544
GeneOntologyBiologicalProcess	T-helper 1 type immune response	MTOR SOCS5 IL4R	4.99e-04	58	55	3	GO:0042088
GeneOntologyBiologicalProcess	cellular response to L-leucine	MTOR RPTOR	5.34e-04	13	55	2	GO:0071233
GeneOntologyBiologicalProcess	lymphocyte differentiation	SFRP1 MTOR SOCS5 CHD7 HECTD1 IL4R VCAM1	5.36e-04	537	55	7	GO:0030098
GeneOntologyBiologicalProcess	regulation of T-helper 2 cell differentiation	SOCS5 IL4R	6.22e-04	14	55	2	GO:0045628
GeneOntologyBiologicalProcess	regulation of T-helper 1 cell differentiation	SOCS5 IL4R	6.22e-04	14	55	2	GO:0045625
GeneOntologyBiologicalProcess	response to L-leucine	MTOR RPTOR	8.18e-04	16	55	2	GO:0043201
GeneOntologyBiologicalProcess	regulation of cellular response to heat	MTOR DNAJC7	8.18e-04	16	55	2	GO:1900034
GeneOntologyBiologicalProcess	negative regulation of lymphocyte differentiation	SFRP1 SOCS5 IL4R	8.65e-04	70	55	3	GO:0045620
GeneOntologyBiologicalProcess	osteoclast differentiation	SFRP1 MTOR IL20 RPTOR	9.16e-04	162	55	4	GO:0030316
GeneOntologyBiologicalProcess	neural crest formation	SFRP1 POLR1B	9.25e-04	17	55	2	GO:0014029
GeneOntologyBiologicalProcess	cellular response to osmotic stress	LRRC8E MTOR RPTOR	9.39e-04	72	55	3	GO:0071470
GeneOntologyBiologicalProcess	regulation of leukocyte differentiation	SFRP1 MTOR IL20 RPTOR SOCS5 IL4R	9.58e-04	429	55	6	GO:1902105
GeneOntologyCellularComponent	TORC1 complex	MTOR RPTOR	1.01e-04	6	55	2	GO:0031931
GeneOntologyCellularComponent	TOR complex	MTOR RPTOR	4.41e-04	12	55	2	GO:0038201
Domain	ARM-type_fold	ARFGEF3 SF3B1 PIK3C2A MTOR RPTOR CIP2A EIF4G1 HSF2BP IPO13 HECTD1 PPP4R4	2.86e-09	339	54	11	IPR016024
Domain	-	SF3B1 MTOR RPTOR CIP2A HSF2BP IPO13 HECTD1 PPP4R4	2.28e-07	222	54	8	1.25.10.10
Domain	ARM-like	SF3B1 MTOR RPTOR CIP2A HSF2BP IPO13 HECTD1 PPP4R4	1.01e-06	270	54	8	IPR011989
Domain	HEAT	SF3B1 MTOR RPTOR IPO13	2.36e-05	58	54	4	IPR000357
Domain	HEAT_REPEAT	SF3B1 MTOR IPO13 PPP4R4	4.97e-05	70	54	4	PS50077
Domain	TPR-like_helical_dom	ADCY10 MTOR CSTF3 SMG5 DNAJC7 UTY	5.53e-05	233	54	6	IPR011990
Domain	SNF2_N	SHPRH CHD8 CHD7	1.07e-04	32	54	3	IPR000330
Domain	SNF2_N	SHPRH CHD8 CHD7	1.07e-04	32	54	3	PF00176
Domain	BRK	CHD8 CHD7	1.22e-04	6	54	2	SM00592
Domain	BRK_domain	CHD8 CHD7	1.22e-04	6	54	2	IPR006576
Domain	BRK	CHD8 CHD7	1.22e-04	6	54	2	PF07533
Domain	SUN_dom	SUCO HECTD1	1.71e-04	7	54	2	IPR012919
Domain	Sad1_UNC	SUCO HECTD1	1.71e-04	7	54	2	PF07738
Domain	-	ADCY10 MTOR CSTF3 DNAJC7 UTY	3.24e-04	207	54	5	1.25.40.10
Domain	PI3/4_kinase_CS	PIK3C2A MTOR	8.41e-04	15	54	2	IPR018936
Domain	-	PIK3C2A MTOR	9.59e-04	16	54	2	1.10.1070.11
Domain	PI3Kc	PIK3C2A MTOR	9.59e-04	16	54	2	SM00146
Domain	PI3/4_kinase_cat_dom	PIK3C2A MTOR	1.22e-03	18	54	2	IPR000403
Domain	PI3_PI4_kinase	PIK3C2A MTOR	1.22e-03	18	54	2	PF00454
Domain	PI3_4_KINASE_3	PIK3C2A MTOR	1.22e-03	18	54	2	PS50290
Domain	PI3_4_KINASE_1	PIK3C2A MTOR	1.22e-03	18	54	2	PS00915
Domain	PI3_4_KINASE_2	PIK3C2A MTOR	1.22e-03	18	54	2	PS00916
Domain	Chromo_domain	CHD8 CHD7	2.17e-03	24	54	2	IPR023780
Domain	Chromo	CHD8 CHD7	2.55e-03	26	54	2	PF00385
Domain	CHROMO_1	CHD8 CHD7	2.96e-03	28	54	2	PS00598
Domain	CHROMO_2	CHD8 CHD7	2.96e-03	28	54	2	PS50013
Domain	Helicase_C	SHPRH CHD8 CHD7	3.67e-03	107	54	3	PF00271
Domain	HELICc	SHPRH CHD8 CHD7	3.67e-03	107	54	3	SM00490
Domain	Helicase_C	SHPRH CHD8 CHD7	3.76e-03	108	54	3	IPR001650
Domain	Chromodomain-like	CHD8 CHD7	3.85e-03	32	54	2	IPR016197
Domain	HELICASE_CTER	SHPRH CHD8 CHD7	3.86e-03	109	54	3	PS51194
Domain	HELICASE_ATP_BIND_1	SHPRH CHD8 CHD7	3.86e-03	109	54	3	PS51192
Domain	DEXDc	SHPRH CHD8 CHD7	3.86e-03	109	54	3	SM00487
Domain	Helicase_ATP-bd	SHPRH CHD8 CHD7	3.96e-03	110	54	3	IPR014001
Domain	Chromo/shadow_dom	CHD8 CHD7	4.09e-03	33	54	2	IPR000953
Domain	CHROMO	CHD8 CHD7	4.09e-03	33	54	2	SM00298
Domain	DNA/RNA_helicase_DEAH_CS	CHD8 CHD7	4.59e-03	35	54	2	IPR002464
Domain	DEAH_ATP_HELICASE	CHD8 CHD7	5.40e-03	38	54	2	PS00690
Pathway	BIOCARTA_MTOR_PATHWAY	MTOR EIF4G1 EIF3A	3.14e-05	22	40	3	M16563
Pathway	REACTOME_MTORC1_MEDIATED_SIGNALLING	MTOR RPTOR EIF4G1	4.11e-05	24	40	3	M3492
Pathway	REACTOME_MTORC1_MEDIATED_SIGNALLING	MTOR RPTOR EIF4G1	4.66e-05	25	40	3	MM14650
Pathway	WP_CAMKK2_PATHWAY	MTOR RPTOR VCAM1	1.09e-04	33	40	3	M40047
Pathway	BIOCARTA_IRES_PATHWAY	EIF4G1 EIF3A	1.63e-04	7	40	2	M22028
Pathway	REACTOME_MTOR_SIGNALLING	MTOR RPTOR EIF4G1	2.09e-04	41	40	3	M27000
Pathway	REACTOME_MTOR_SIGNALLING	MTOR RPTOR EIF4G1	2.25e-04	42	40	3	MM14638
Pathway	WP_TRANSLATION_INHIBITORS_IN_CHRONICALLY_ACTIVATED_PDGFRA_CELLS	MTOR RPTOR EIF4G1	2.95e-04	46	40	3	M39805
Pathway	KEGG_MEDICUS_REFERENCE_TSC1_2_MTORC1_SIGNALING_PATHWAY	MTOR RPTOR	4.25e-04	11	40	2	M47915
Pathway	REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING	SOCS5 IL4R	6.99e-04	14	40	2	MM15321
Pathway	KEGG_MEDICUS_REFERENCE_FLCN_MTORC1_SIGNALING_PATHWAY	MTOR RPTOR	6.99e-04	14	40	2	M47922
Pathway	KEGG_MEDICUS_REFERENCE_GATOR1_MTORC1_SIGNALING_PATHWAY	MTOR RPTOR	6.99e-04	14	40	2	M47918
Pathway	PID_IL4_2PATHWAY	MTOR SOCS5 IL4R	7.82e-04	64	40	3	M28
Pathway	BIOCARTA_EIF_PATHWAY	EIF4G1 EIF3A	9.19e-04	16	40	2	M7721
Pathway	KEGG_MEDICUS_REFERENCE_AUTOPHAGY_VESICLE_NUCLEATION_ELONGATION_MATURATION_MTORC1_PI3KC3_C1	MTOR RPTOR	9.19e-04	16	40	2	M47457
Pubmed	Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation.	MTOR RPTOR EIF4G1	7.88e-08	6	56	3	18955708
Pubmed	eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy.	MTOR RPTOR EIF4G1	7.88e-08	6	56	3	18426977
Pubmed	mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin.	MTOR EIF4G1 EIF3A	2.20e-07	8	56	3	16541103
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	LRRC8E CTC1 MTOR RPTOR SPEG EIF4G1 CHD8 SMG5 MED13L HECTD1 IL4R	1.27e-06	1105	56	11	35748872
Pubmed	mTOR kinase-dependent, but raptor-independent regulation of downstream signaling is important for cell cycle exit and myogenic differentiation.	MTOR RPTOR	2.55e-06	2	56	2	25486193
Pubmed	The mTORC1 component RPTOR is required for maintenance of the foundational spermatogonial stem cell pool in mice†.	MTOR RPTOR	2.55e-06	2	56	2	30202948
Pubmed	Investigation of Novel Regulation of N-myristoyltransferase by Mammalian Target of Rapamycin in Breast Cancer Cells.	MTOR NMT1	2.55e-06	2	56	2	30154572
Pubmed	CHD8 interacts with CHD7, a protein which is mutated in CHARGE syndrome.	CHD8 CHD7	2.55e-06	2	56	2	20453063
Pubmed	eIF4G-driven translation initiation of downstream ORFs in mammalian cells.	MTOR EIF4G1	2.55e-06	2	56	2	32941651
Pubmed	Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking.	MTOR RPTOR	2.55e-06	2	56	2	17301289
Pubmed	Hepatic overexpression of a dominant negative form of raptor enhances Akt phosphorylation and restores insulin sensitivity in K/KAy mice.	MTOR RPTOR	2.55e-06	2	56	2	18270303
Pubmed	Colorectal carcinomas with CpG island methylator phenotype 1 frequently contain mutations in chromatin regulators.	CHD8 CHD7	2.55e-06	2	56	2	24211491
Pubmed	Conditional Knockout of Raptor/mTORC1 Results in Dentin Malformation.	MTOR RPTOR	2.55e-06	2	56	2	30984011
Pubmed	Hepatic peroxisomal β-oxidation suppresses lipophagy via RPTOR acetylation and MTOR activation.	MTOR RPTOR	2.55e-06	2	56	2	32687428
Pubmed	Human cytomegalovirus infection induces rapamycin-insensitive phosphorylation of downstream effectors of mTOR kinase.	MTOR EIF4G1	2.55e-06	2	56	2	15452223
Pubmed	Deletion of mTORC1 Activity in CD4+ T Cells Is Associated with Lung Fibrosis and Increased γδ T Cells.	MTOR RPTOR	2.55e-06	2	56	2	27649073
Pubmed	mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors.	MTOR RPTOR	2.55e-06	2	56	2	29786082
Pubmed	Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning.	MTOR RPTOR	2.55e-06	2	56	2	27018708
Pubmed	The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity.	MTOR RPTOR	2.55e-06	2	56	2	16847060
Pubmed	Mitotic raptor promotes mTORC1 activity, G(2)/M cell cycle progression, and internal ribosome entry site-mediated mRNA translation.	MTOR RPTOR	2.55e-06	2	56	2	20439490
Pubmed	Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells.	MTOR RPTOR	7.63e-06	3	56	2	20233713
Pubmed	Distribution and association of mTOR with its cofactors, raptor and rictor, in cumulus cells and oocytes during meiotic maturation in mice.	MTOR RPTOR	7.63e-06	3	56	2	23440873
Pubmed	Oligodendrocyte precursor survival and differentiation requires chromatin remodeling by Chd7 and Chd8.	CHD8 CHD7	7.63e-06	3	56	2	30108144
Pubmed	Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1.	MTOR RPTOR	7.63e-06	3	56	2	21471201
Pubmed	mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition.	MTOR RPTOR	7.63e-06	3	56	2	25385646
Pubmed	The Potential Role of BRCA1-Associated ATM Activator-1 (BRAT1) in Regulation of mTOR.	MTOR RPTOR	7.63e-06	3	56	2	25657994
Pubmed	Expression of the mTOR pathway regulators in human pituitary adenomas indicates the clinical course.	MTOR RPTOR	7.63e-06	3	56	2	23898069
Pubmed	mTOR has a developmental stage-specific role in mitochondrial fitness independent of conventional mTORC1 and mTORC2 and the kinase activity.	MTOR RPTOR	7.63e-06	3	56	2	28813526
Pubmed	Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1.	MTOR RPTOR	7.63e-06	3	56	2	12912989
Pubmed	Localization of Rheb to the endomembrane is critical for its signaling function.	MTOR RPTOR	7.63e-06	3	56	2	16631613
Pubmed	Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function.	MTOR RPTOR	7.63e-06	3	56	2	22143799
Pubmed	Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility.	MTOR RPTOR	7.63e-06	3	56	2	19724909
Pubmed	mTOR Signaling in Growth, Metabolism, and Disease.	MTOR RPTOR	7.63e-06	3	56	2	28283069
Pubmed	Interferon-gamma induces human vascular smooth muscle cell proliferation and intimal expansion by phosphatidylinositol 3-kinase dependent mammalian target of rapamycin raptor complex 1 activation.	MTOR RPTOR	7.63e-06	3	56	2	17656678
Pubmed	Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy.	MTOR RPTOR	7.63e-06	3	56	2	20008564
Pubmed	Conditional Disruption of Raptor Reveals an Essential Role for mTORC1 in B Cell Development, Survival, and Metabolism.	MTOR RPTOR	7.63e-06	3	56	2	27521345
Pubmed	mTORC1 Signaling is a Critical Regulator of Postnatal Tendon Development.	MTOR RPTOR	7.63e-06	3	56	2	29215029
Pubmed	Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1.	MTOR RPTOR	7.63e-06	3	56	2	18614546
Pubmed	mTORC1 pathway disruption ameliorates brain inflammation following stroke via a shift in microglia phenotype from M1 type to M2 type.	MTOR RPTOR	7.63e-06	3	56	2	27342766
Pubmed	Intestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTORC1) through phosphorylation of Raptor Thr-908.	MTOR RPTOR	7.63e-06	3	56	2	22356909
Pubmed	Parkin ubiquitinates mTOR to regulate mTORC1 activity under mitochondrial stress.	MTOR RPTOR	7.63e-06	3	56	2	25007995
Pubmed	Cutting edge: mTORC1 in intestinal CD11c+ CD11b+ dendritic cells regulates intestinal homeostasis by promoting IL-10 production.	MTOR RPTOR	7.63e-06	3	56	2	22504639
Pubmed	The human myometrium differentially expresses mTOR signalling components before and during pregnancy: evidence for regulation by progesterone.	MTOR RPTOR	7.63e-06	3	56	2	23541542
Pubmed	Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.	MTOR RPTOR	7.63e-06	3	56	2	12408816
Pubmed	GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling.	MTOR RPTOR	7.63e-06	3	56	2	26348909
Pubmed	mTORC1 directly phosphorylates and activates ERα upon estrogen stimulation.	MTOR RPTOR	7.63e-06	3	56	2	26522726
Pubmed	Increase of microRNA-210, decrease of raptor gene expression and alteration of mammalian target of rapamycin regulated proteins following mithramycin treatment of human erythroid cells.	MTOR RPTOR	7.63e-06	3	56	2	25849663
Pubmed	The Rapamycin-Sensitive Complex of Mammalian Target of Rapamycin Is Essential to Maintain Male Fertility.	MTOR RPTOR	7.63e-06	3	56	2	26683665
Pubmed	Leucine regulates autophagy via acetylation of the mTORC1 component raptor.	MTOR RPTOR	7.63e-06	3	56	2	32561715
Pubmed	Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation.	MTOR RPTOR	7.63e-06	3	56	2	19864431
Pubmed	Reconstitution of leucine-mediated autophagy via the mTORC1-Barkor pathway in vitro.	MTOR RPTOR	7.63e-06	3	56	2	22258093
Pubmed	TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function.	MTOR RPTOR	7.63e-06	3	56	2	12747827
Pubmed	Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells.	MTOR RPTOR	7.63e-06	3	56	2	24567410
Pubmed	mTOR has distinct functions in generating versus sustaining humoral immunity.	MTOR RPTOR	7.63e-06	3	56	2	27760048
Pubmed	Essential role of D1R in the regulation of mTOR complex1 signaling induced by cocaine.	MTOR RPTOR	7.63e-06	3	56	2	26314207
Pubmed	Langerhans cell homeostasis in mice is dependent on mTORC1 but not mTORC2 function.	MTOR RPTOR	7.63e-06	3	56	2	23212520
Pubmed	Genetic variations of mTORC1 genes and risk of gastric cancer in an Eastern Chinese population.	MTOR RPTOR	7.63e-06	3	56	2	23423739
Pubmed	The ATP-dependent chromatin remodeling enzymes CHD6, CHD7, and CHD8 exhibit distinct nucleosome binding and remodeling activities.	CHD8 CHD7	7.63e-06	3	56	2	28533432
Pubmed	Reduced juvenile long-term depression in tuberous sclerosis complex is mitigated in adults by compensatory recruitment of mGluR5 and Erk signaling.	MTOR RPTOR	7.63e-06	3	56	2	23966835
Pubmed	mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress.	MTOR RPTOR	7.63e-06	3	56	2	24958889
Pubmed	Architecture of human mTOR complex 1.	MTOR RPTOR	7.63e-06	3	56	2	26678875
Pubmed	Hexokinase-II positively regulates glucose starvation-induced autophagy through TORC1 inhibition.	MTOR RPTOR	7.63e-06	3	56	2	24462113
Pubmed	Autism-linked CHD gene expression patterns during development predict multi-organ disease phenotypes.	CHD8 CHD7	7.63e-06	3	56	2	30277262
Pubmed	Stress and mTORture signaling.	MTOR RPTOR	7.63e-06	3	56	2	17041623
Pubmed	mLST8 Promotes mTOR-Mediated Tumor Progression.	MTOR RPTOR	7.63e-06	3	56	2	25906254
Pubmed	mTOR phosphorylated at S2448 binds to raptor and rictor.	MTOR RPTOR	7.63e-06	3	56	2	19145465
Pubmed	Collybistin binds and inhibits mTORC1 signaling: a potential novel mechanism contributing to intellectual disability and autism.	MTOR EIF3A	7.63e-06	3	56	2	25898924
Pubmed	mTOR/Raptor signaling is critical for skeletogenesis in mice through the regulation of Runx2 expression.	MTOR RPTOR	7.63e-06	3	56	2	28686577
Pubmed	VHL suppresses RAPTOR and inhibits mTORC1 signaling in clear cell renal cell carcinoma.	MTOR RPTOR	7.63e-06	3	56	2	34290272
Pubmed	mTOR inhibition rescues osteopenia in mice with systemic sclerosis.	MTOR IL4R	7.63e-06	3	56	2	25534817
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	SF3B1 MTOR CIP2A EIF4G1 CSTF3 EIF3A DNAJC7 HECTD1	8.03e-06	638	56	8	33239621
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ARFGEF3 ARHGEF28 HIPK4 PIK3C2A MTOR RPTOR EIF4G1 HECTD1 PPP4R4	8.95e-06	861	56	9	36931259
Pubmed	Vinculin: a novel marker for quiescent and activated hepatic stellate cells in human and rat livers.	MTOR RPTOR	1.52e-05	4	56	2	12719976
Pubmed	A conserved role of IQGAP1 in regulating TOR complex 1.	MTOR RPTOR	1.52e-05	4	56	2	22328503
Pubmed	mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s.	MTOR RPTOR	1.52e-05	4	56	2	16919458
Pubmed	Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins.	MTOR RPTOR	1.52e-05	4	56	2	18504440
Pubmed	Dual Roles of Mammalian Target of Rapamycin in Regulating Liver Injury and Tumorigenesis in Autophagy-Defective Mouse Liver.	MTOR RPTOR	1.52e-05	4	56	2	31095752
Pubmed	Transient exposure to calcium ionophore enables in vitro fertilization in sterile mouse models.	ADCY10 KCNU1	1.52e-05	4	56	2	27627854
Pubmed	mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.	MTOR RPTOR	1.52e-05	4	56	2	12150925
Pubmed	The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif.	MTOR RPTOR	1.52e-05	4	56	2	12604610
Pubmed	mTOR disruption causes intestinal epithelial cell defects and intestinal atrophy postinjury in mice.	MTOR RPTOR	1.52e-05	4	56	2	26631481
Pubmed	Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21.	MTOR RPTOR	1.52e-05	4	56	2	26554817
Pubmed	Characterization of the Raptor/4E-BP1 interaction by chemical cross-linking coupled with mass spectrometry analysis.	MTOR RPTOR	1.52e-05	4	56	2	24403073
Pubmed	The tight junction protein TJP1 regulates the feeding-modulated hepatic circadian clock.	MTOR RPTOR	1.52e-05	4	56	2	32001717
Pubmed	Ribavirin enhances interferon signaling via stimulation of mTOR and p53 activities.	MTOR RPTOR	1.52e-05	4	56	2	19619545
Pubmed	Identification and characterization of FAM124B as a novel component of a CHD7 and CHD8 containing complex.	CHD8 CHD7	1.52e-05	4	56	2	23285124
Pubmed	Characterization of p70 S6 kinase 1 in early development of mouse embryos.	MTOR RPTOR	1.52e-05	4	56	2	19877273
Pubmed	Loss of mTOR signaling affects cone function, cone structure and expression of cone specific proteins without affecting cone survival.	MTOR RPTOR	1.52e-05	4	56	2	25887293
Pubmed	Distinct roles of Rheb and Raptor in activating mTOR complex 1 for the self-renewal of hematopoietic stem cells.	MTOR RPTOR	1.52e-05	4	56	2	29175333
Pubmed	E2F1 regulates cellular growth by mTORC1 signaling.	MTOR RPTOR	1.52e-05	4	56	2	21283628
Pubmed	Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.	MTOR RPTOR	1.52e-05	4	56	2	16603397
Pubmed	Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency.	MTOR RPTOR	1.52e-05	4	56	2	31636454
Pubmed	Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function.	MTOR RPTOR	1.52e-05	4	56	2	24516149
Pubmed	Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis.	MTOR RPTOR	1.52e-05	4	56	2	23429704
Pubmed	Role of mTOR in podocyte function and diabetic nephropathy in humans and mice.	MTOR RPTOR	1.52e-05	4	56	2	21606591
Pubmed	mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.	MTOR RPTOR	1.52e-05	4	56	2	21179166
Pubmed	Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling.	MTOR RPTOR	1.52e-05	4	56	2	26831088
Pubmed	Signaling by target of rapamycin proteins in cell growth control.	MTOR RPTOR	1.52e-05	4	56	2	15755954
Pubmed	GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor.	MTOR RPTOR	1.52e-05	4	56	2	31112131
Pubmed	Different roles for the TOS and RAIP motifs of the translational regulator protein 4E-BP1 in the association with raptor and phosphorylation by mTOR in the regulation of cell size.	MTOR RPTOR	1.52e-05	4	56	2	16824195
Interaction	EIF4EBP2 interactions	MTOR RPTOR EIF4G1 EIF3A	3.42e-06	38	55	4	int:EIF4EBP2
Interaction	UBAP2L interactions	SF3B1 PIK3C2A MTOR RPTOR SMG5 HECTD1 VCAM1	1.59e-05	298	55	7	int:UBAP2L
Interaction	TACSTD2 interactions	ARFGEF3 MTOR RPTOR CIP2A IPO13	2.68e-05	129	55	5	int:TACSTD2
Interaction	NPY2R interactions	ARFGEF3 MTOR CIP2A IPO13	3.16e-05	66	55	4	int:NPY2R
Interaction	YWHAZ interactions	SF3B1 ARHGEF28 PIK3C2A PTPRO MTOR RPTOR SPEG EIF3A DNAJC7 SUCO HECTD1 VCAM1 PPP4R4	4.16e-05	1319	55	13	int:YWHAZ
Interaction	GDI2P1 interactions	MTOR RPTOR	4.37e-05	4	55	2	int:GDI2P1
Interaction	CD40 interactions	ARFGEF3 MTOR CIP2A IPO13 IL4R	6.05e-05	153	55	5	int:CD40
Cytoband	1q24	ADCY10 SUCO	2.74e-04	20	56	2	1q24
GeneFamily	MTOR complex 1\|MTOR complex 2	MTOR RPTOR	2.44e-05	4	37	2	1332
CoexpressionAtlas	DevelopingGonad_e18.5_epididymis_emap-13166_k-means-cluster#1_top-relative-expression-ranked_1000	SFRP1 SF3B1 EIF3A REEP5 UTY	5.80e-06	105	52	5	gudmap_developingGonad_e18.5_epididymis_1000_k1
CoexpressionAtlas	DevelopingGonad_e16.5_epididymis_emap-29702_k-means-cluster#1_top-relative-expression-ranked_1000	SFRP1 SF3B1 EIF3A REEP5 UTY	1.31e-05	124	52	5	gudmap_developingGonad_e16.5_epididymis_1000_k1
CoexpressionAtlas	DevelopingGonad_e14.5_ epididymis_emap-29141_top-relative-expression-ranked_1000	SFRP1 SF3B1 WASHC4 EIF4G1 CSTF3 CHD8 EIF3A REEP5 PRDM5 UTY	2.07e-05	801	52	10	gudmap_developingGonad_e14.5_ epididymis_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_top-relative-expression-ranked_500	SFRP1 PIK3C2A PTPRO RPTOR EIF4G1 SHPRH BRINP1	6.59e-05	416	52	7	gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_500
CoexpressionAtlas	DevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#2_top-relative-expression-ranked_1000	SFRP1 SF3B1 EIF3A REEP5 UTY	8.64e-05	184	52	5	gudmap_developingGonad_e14.5_ epididymis_1000_k2
CoexpressionAtlas	DevelopingGonad_e14.5_ ovary_emap-6699_top-relative-expression-ranked_1000	SF3B1 EXD1 CIP2A EIF4G1 SHPRH HSF2BP CHD8 EIF3A REEP5	9.97e-05	776	52	9	gudmap_developingGonad_e14.5_ ovary_1000
CoexpressionAtlas	DevelopingGonad_e18.5_ovary_emap-12283_top-relative-expression-ranked_1000	SF3B1 WASHC4 EXD1 CIP2A EIF4G1 HSF2BP CHD8 EIF3A REEP5	1.02e-04	778	52	9	gudmap_developingGonad_e18.5_ovary_1000
CoexpressionAtlas	DevelopingGonad_e16.5_epididymis_emap-29702_top-relative-expression-ranked_1000	SFRP1 SF3B1 WASHC4 EIF4G1 CHD8 EIF3A REEP5 PRDM5 UTY	1.14e-04	790	52	9	gudmap_developingGonad_e16.5_epididymis_1000
CoexpressionAtlas	DevelopingKidney_e15.5_anlage of loop of Henle_emap-31283_top-relative-expression-ranked_1000	SFRP1 WASHC4 PIK3C2A PTPRO RPTOR SLCO1A2 SHPRH CHD7 SUCO	1.20e-04	795	52	9	gudmap_developingKidney_e15.5_anlage of loop of Henle_1000
CoexpressionAtlas	DevelopingGonad_e12.5_ovary_emap-28876_top-relative-expression-ranked_1000	SFRP1 SF3B1 CIP2A EIF4G1 SHPRH CSTF3 CHD8 EIF3A REEP5	1.30e-04	804	52	9	gudmap_developingGonad_e12.5_ovary_1000
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_2500_k-means-cluster#1	NR2C1 PIK3C2A SLCO1A2 CHD7 EIF3A NMT1 HECTD1	1.39e-04	469	52	7	Facebase_RNAseq_e8.5_Floor Plate_2500_K1
CoexpressionAtlas	DevelopingGonad_e11.5_ovary + mesonephros_emap-3226_top-relative-expression-ranked_1000	SFRP1 SF3B1 CIP2A EIF4G1 CSTF3 CHD8 CHD7 EIF3A REEP5	1.44e-04	815	52	9	gudmap_developingGonad_e11.5_ovary + mesonephros_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#2_top-relative-expression-ranked_500	SFRP1 PIK3C2A RPTOR EIF4G1 SHPRH	1.57e-04	209	52	5	gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_500_k2
CoexpressionAtlas	DevelopingGonad_e12.5_epididymis_emap-29139_k-means-cluster#3_top-relative-expression-ranked_500	SF3B1 EIF3A REEP5 UTY	1.75e-04	114	52	4	gudmap_developingGonad_e12.5_epididymis_k3_500
CoexpressionAtlas	DevelopingGonad_P2_epididymis_emap-30199_k-means-cluster#4_top-relative-expression-ranked_500	SFRP1 EIF3A REEP5	2.98e-04	53	52	3	gudmap_developingGonad_P2_epididymis_500_k4
CoexpressionAtlas	DevelopingGonad_P2_epididymis_emap-30199_k-means-cluster#1_top-relative-expression-ranked_1000	SFRP1 SF3B1 EIF3A REEP5	3.43e-04	136	52	4	gudmap_developingGonad_P2_epididymis_1000_k1
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_k-means-cluster#5_top-relative-expression-ranked_1000	SFRP1 PIK3C2A RPTOR EIF4G1 SHPRH SUCO	4.05e-04	397	52	6	gudmap_developingLowerUrinaryTract_e14.5_ bladder_1000_k5
CoexpressionAtlas	DevelopingGonad_e12.5_ovary_emap-28876_k-means-cluster#4_top-relative-expression-ranked_500	SF3B1 EIF3A REEP5	4.30e-04	60	52	3	gudmap_developingGonad_e12.5_ovary_k4_500
CoexpressionAtlas	DevelopingGonad_e12.5_epididymis_emap-29139_top-relative-expression-ranked_500	SF3B1 EIF4G1 CHD8 EIF3A REEP5 UTY	4.38e-04	403	52	6	gudmap_developingGonad_e12.5_epididymis_500
CoexpressionAtlas	DevelopingGonad_e12.5_ovary_emap-28876_k-means-cluster#4_top-relative-expression-ranked_1000	SFRP1 SF3B1 EIF3A REEP5	4.98e-04	150	52	4	gudmap_developingGonad_e12.5_ovary_k4_1000
CoexpressionAtlas	DevelopingGonad_e11.5_ovary + mesonephros_emap-3226_k-means-cluster#4_top-relative-expression-ranked_1000	SFRP1 SF3B1 EIF3A REEP5	5.77e-04	156	52	4	gudmap_developingGonad_e11.5_ovary + mesonephros_k4_1000
CoexpressionAtlas	DevelopingGonad_e16.5_ovary_emap-9563_top-relative-expression-ranked_1000	SF3B1 EXD1 EIF4G1 SHPRH HSF2BP CHD8 EIF3A REEP5	6.52e-04	795	52	8	gudmap_developingGonad_e16.5_ovary_1000
CoexpressionAtlas	DevelopingGonad_e18.5_epididymis_emap-13166_top-relative-expression-ranked_1000	SFRP1 SF3B1 WASHC4 EIF4G1 CHD8 EIF3A REEP5 UTY	6.73e-04	799	52	8	gudmap_developingGonad_e18.5_epididymis_1000
CoexpressionAtlas	DevelopingKidney_e15.5_cortic collect duct_emap-28132_k-means-cluster#4_top-relative-expression-ranked_500	WASHC4 PIK3C2A CSTF3 SUCO	6.80e-04	163	52	4	gudmap_developingKidney_e15.5_cortic collect duct_500_k4
CoexpressionAtlas	DevelopingGonad_e12.5_testes_emap-29069_top-relative-expression-ranked_200	SFRP1 SF3B1 CHD8 REEP5	7.12e-04	165	52	4	gudmap_developingGonad_e12.5_testes_200
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_top-relative-expression-ranked_1000	LRRC8E SFRP1 PIK3C2A RPTOR EIF4G1 SHPRH SUCO VCAM1	7.42e-04	811	52	8	gudmap_developingLowerUrinaryTract_e14.5_ bladder_1000
CoexpressionAtlas	DevelopingGonad_e14.5_ testes_emap-6710_k-means-cluster#3_top-relative-expression-ranked_1000	EXD1 HSF2BP CHD8	7.94e-04	74	52	3	gudmap_developingGonad_e14.5_ testes_1000_k3
Computational	Neighborhood of RAP1A	NR2C1 PIK3C2A CSTF3 NMT1 MFN1	9.51e-05	140	36	5	MORF_RAP1A
Computational	Neighborhood of PPP5C	NR2C1 CSTF3 NMT1 MFN1	2.30e-04	91	36	4	MORF_PPP5C
Drug	monastrol; Down 200; 100uM; PC3; HG-U133A	LRRC8E ARHGEF28 RRP1B SOCS5 OGFOD1 EIF3A PMEL NMT1 UTY	1.32e-09	199	56	9	668_DN
Drug	Azathymine, 6 [932-53-6]; Down 200; 31.4uM; MCF7; HT_HG-U133A	WASHC4 MTOR TOP6BL MED13L CFAP44 UTY	8.56e-06	196	56	6	2827_DN
Disease	interstitial cystitis (is_marker_for)	MTOR VCAM1	3.52e-05	5	56	2	DOID:13949 (is_marker_for)
Disease	CHARGE syndrome (implicated_via_orthology)	CHD8 CHD7	7.38e-05	7	56	2	DOID:0050834 (implicated_via_orthology)
Disease	blood cobalt measurement	SFRP1 RPTOR PRDM5	9.46e-04	101	56	3	EFO_0007577
Disease	chronic kidney disease (biomarker_via_orthology)	VCAM1 MFN1	1.30e-03	28	56	2	DOID:784 (biomarker_via_orthology)
Disease	lysophosphatidylethanolamine 20:4 measurement	SFRP1 SLCO1A2	1.39e-03	29	56	2	EFO_0010370
Disease	Ovarian Mucinous Adenocarcinoma	MTOR SPEG	1.59e-03	31	56	2	C1335167
Disease	lysophosphatidylethanolamine measurement	SFRP1 SLCO1A2	2.77e-03	41	56	2	EFO_0010225
Disease	autism spectrum disorder (implicated_via_orthology)	CHD8 BRINP1 CHD7	3.04e-03	152	56	3	DOID:0060041 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
RNCKLLDSLKHMDLE	CHD8	956	Q9HCK8
RLFLLCHKEALMKRN	CTC1	731	Q2NKJ3
QLDLFSCMLKHRLKL	BRINP1	716	O60477
LLKEKMEHLIGACRD	ANKRD35	911	Q8N283
RKAMHLKCARFLEED	ADCY10	946	Q96PN6
LKHHCNKVLLRVRML	CHD7	1731	Q9P2D1
RHMNKCILSLRDLKV	CFAP44	1211	Q96MT7
RRKLLMEHIFKLQEF	NR2C1	471	P13056
DVCDLAFSLKKMLIR	PRDM5	576	Q9NQX1
LILALFMSICRTEKK	PCDH12	731	Q9NPG4
LHMDKDLKAGCLVRV	MFN1	146	Q8IWA4
DLRKALCLIKDMIAT	ARHGEF28	1026	Q8N1W1
LKECMKLFRSEALFL	OGFOD1	341	Q8N543
LLFKAIHNLLERCLM	MED13L	121	Q71F56
KMVEINFLCVHKKLR	NMT1	241	P30419
IIKNELKLLHCMRGL	HIPK4	51	Q8NE63
MILEDKRILKVIHDC	EXD1	146	Q8NHP7
LKEGLDLRMVIFKCL	PIK3C2A	1161	O00443
KLFQRCLMKVLHIDL	CSTF3	86	Q12996
EVARLCFLKMHLLLI	KCNU1	541	A8MYU2
FLRDHLKVMRVKCEE	LRRC8E	481	Q6NSJ5
LIILRKKHLQMAREC	PTPRO	841	Q16827
RKASLALIRKMIHFC	HECTD1	541	Q9ULT8
ALIRKMIHFCSEALL	HECTD1	546	Q9ULT8
LTKLLPCFLEHNMKR	IL4R	306	P24394
MLKYLELCVDLRKSH	EIF3A	51	Q14152
KAEFRKLCDNLRMHL	EIF3A	191	Q14152
MLKDLFELLVACVAK	ARFGEF3	1561	Q5TH69
LTEAIMHDCVVKLLK	EIF4G1	911	Q04637
HRFKILKAECLAMLG	DNAJC7	176	Q99615
FLTIKKDLRLCHAHM	IL20	116	Q9NYY1
KEMVKEFTLLCRGLH	IPO13	941	O94829
QELHKLMARCFLKLG	MTOR	1741	P42345
LLLICSLCKHLKKMR	TAS2R19	196	P59542
LEQLKMDCEHFKARL	HSF2BP	71	O75031
CRAKEIHLRLGLMFK	UTY	161	O14607
KKMFCEVDRSLLCLL	TRIM48	116	Q8IWZ4
KVLVCRAKLHIDEMD	VCAM1	191	P19320
HLKKFLLDRMFLVAK	TEX47	41	Q8TBZ9
RIKVFLDVLMKEVLC	RRP1B	141	Q14684
DKHLLQQLEMCVRKL	PPP4R4	641	Q6NUP7
RNKLRELCVKLMFLH	SMG5	56	Q9UPR3
RKIHLSELMLEKCPF	SOCS5	206	O75159
TDCLVIKHFLRKIIM	TOP6BL	121	Q8N6T0
SLLKRMLKCLIFEGL	SHPRH	481	Q149N8
HRIRCLSKLKMFLLA	SLCO1A2	11	P46721
RFLHEKNCMTDLLAK	REEP5	11	Q00765
MDLVLKRCLLHLAVI	PMEL	1	P40967
HLCASEFALRMKIKE	SFRP1	201	Q8N474
LPLAFMKKRHCEKIE	RPTOR	26	Q8N122
LCGDDTLKMHIAKIL	CIP2A	426	Q8TCG1
MALKLIHKEFLELAR	UBE2DNL	1	Q8IWF7
RLLQPALLKCKMHFD	SPEG	1006	Q15772
MRICFELLELLKAHK	SF3B1	1056	O75533
MKKHRRALALVSCLF	SUCO	1	Q9UBS9
LKCMLEKYERHLAEI	TSGA10	36	Q9BZW7
LCRLVELLKAIEHMF	WASHC4	476	Q2M389
LCLMTRKLFALAKGE	POLR1B	346	Q9H9Y6