Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	NAD+ nucleotidase, cyclic ADP-ribose generating	IL1RAPL2 TLR2	3.13e-04	16	33	2	GO:0061809
GeneOntologyMolecularFunction	ATP hydrolysis activity	ABCC2 IQCA1 DNAH7 DDX60 MCM9	7.32e-04	441	33	5	GO:0016887
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	RAB12 ABCC2 IQCA1 DNAH7 DDX60 MCM9	1.51e-03	775	33	6	GO:0017111
GeneOntologyMolecularFunction	hydrolase activity, hydrolyzing N-glycosyl compounds	IL1RAPL2 TLR2	2.09e-03	41	33	2	GO:0016799
GeneOntologyMolecularFunction	pyrophosphatase activity	RAB12 ABCC2 IQCA1 DNAH7 DDX60 MCM9	2.26e-03	839	33	6	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	RAB12 ABCC2 IQCA1 DNAH7 DDX60 MCM9	2.28e-03	840	33	6	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	RAB12 ABCC2 IQCA1 DNAH7 DDX60 MCM9	2.28e-03	840	33	6	GO:0016818
GeneOntologyMolecularFunction	ATP-dependent activity	ABCC2 IQCA1 DNAH7 DDX60 MCM9	3.15e-03	614	33	5	GO:0140657
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	FER MAP3K15 CHKA PANK3 PIK3CB	5.79e-03	709	33	5	GO:0016773
Domain	TIR	IL1RAPL2 TLR2	6.23e-04	21	33	2	SM00255
Domain	TIR	IL1RAPL2 TLR2	6.84e-04	22	33	2	PF01582
Domain	-	IL1RAPL2 TLR2	7.48e-04	23	33	2	3.40.50.10140
Domain	TIR	IL1RAPL2 TLR2	8.15e-04	24	33	2	PS50104
Domain	TIR_dom	IL1RAPL2 TLR2	8.85e-04	25	33	2	IPR000157
Domain	-	RAB12 ABCC2 IQCA1 DNAH7 DDX60 MCM9	1.75e-03	746	33	6	3.40.50.300
Domain	AAA+_ATPase	ABCC2 DNAH7 MCM9	2.07e-03	144	33	3	IPR003593
Domain	AAA	ABCC2 DNAH7 MCM9	2.07e-03	144	33	3	SM00382
Domain	BTB-kelch_protein	KLHL25 KLHL7	2.61e-03	43	33	2	IPR017096
Domain	-	KLHL25 KLHL7	3.25e-03	48	33	2	2.120.10.80
Domain	P-loop_NTPase	RAB12 ABCC2 IQCA1 DNAH7 DDX60 MCM9	3.33e-03	848	33	6	IPR027417
Domain	Kelch-typ_b-propeller	KLHL25 KLHL7	4.24e-03	55	33	2	IPR015915
Domain	Kelch	KLHL25 KLHL7	4.70e-03	58	33	2	SM00612
Domain	BACK	KLHL25 KLHL7	5.03e-03	60	33	2	SM00875
Domain	BACK	KLHL25 KLHL7	5.19e-03	61	33	2	PF07707
Domain	BACK	KLHL25 KLHL7	5.19e-03	61	33	2	IPR011705
Domain	Kelch_1	KLHL25 KLHL7	6.78e-03	70	33	2	PF01344
Domain	Kelch_1	KLHL25 KLHL7	6.78e-03	70	33	2	IPR006652
Domain	NA-bd_OB-fold	DIS3 MCM9	9.42e-03	83	33	2	IPR012340
Domain	Kinase-like_dom	FER MAP3K15 CHKA PIK3CB	1.47e-02	542	33	4	IPR011009
Pubmed	Identification of a TLR2-regulated gene signature associated with tumor cell growth in gastric cancer.	IL6ST TLR2	9.28e-07	2	34	2	28481875
Pubmed	Trypanosoma cruzi, the causative agent of Chagas disease, modulates interleukin-6-induced STAT3 phosphorylation via gp130 cleavage in different host cells.	IL6ST TLR2	2.78e-06	3	34	2	23253440
Pubmed	STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation.	IL6ST TLR2	9.26e-06	5	34	2	23079657
Pubmed	Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia.	PIK3CB TLR2	2.32e-04	23	34	2	19047410
Pubmed	Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein.	RAB12 AHNAK	4.52e-04	32	34	2	28656962
Pubmed	Tandem immunoprecipitation of phosphotyrosine-mass spectrometry (TIPY-MS) indicates C19ORF19 becomes tyrosine-phosphorylated and associated with activated epidermal growth factor receptor.	FER DDX60	4.81e-04	33	34	2	18271526
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	FER TDRD3 KLHL7 DDX60 AHNAK	6.51e-04	724	34	5	36232890
Pubmed	Update on the Kelch-like (KLHL) gene family.	KLHL25 KLHL7	7.43e-04	41	34	2	23676014
GeneFamily	Kelch like\|BTB domain containing	KLHL25 KLHL7	1.92e-03	42	28	2	617
GeneFamily	CD molecules\|I-set domain containing\|Immunoglobulin like domain containing\|Interleukin receptors\|TIR domain containing	IL1RAPL2 IL6ST	1.92e-03	42	28	2	602
Disease	Eosinophilia	IL6ST TLR2	3.18e-05	8	32	2	C0014457
Disease	creatinine measurement, chronic kidney disease	CERS2 PDILT	6.63e-04	35	32	2	EFO_0003884, EFO_0004518
Disease	Rheumatoid Arthritis	ABCC2 IL6ST TLR2	8.81e-04	174	32	3	C0003873
Disease	severe acute respiratory syndrome (is_marker_for)	SERPINA3 TLR2	1.19e-03	47	32	2	DOID:2945 (is_marker_for)
Disease	Liver Cirrhosis, Experimental	STARD13 MAGEE1 ABCC2 RBL2 AHNAK	1.37e-03	774	32	5	C0023893
Disease	Colorectal Neoplasms	ABCC2 IL6ST TLR2	3.32e-03	277	32	3	C0009404
Disease	S-7-hydroxywarfarin to S-warfarin ratio measurement	STARD13 IQCA1	3.50e-03	81	32	2	EFO_0803334
Disease	Drug toxicity	ABCC2 TLR2	3.76e-03	84	32	2	C0013221
Disease	Adverse reaction to drug	ABCC2 TLR2	3.76e-03	84	32	2	C0041755
Disease	Reperfusion Injury	IL6ST TLR2	4.21e-03	89	32	2	C0035126
Disease	status epilepticus (biomarker_via_orthology)	ABCC2 IL6ST	5.28e-03	100	32	2	DOID:1824 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FYLSKKKWVMVPMMS	SERPINA3	231	P01011
DWSLKIPKMKMPKFS	AHNAK	1121	Q09666
NGKWKTPKFKMPDMH	AHNAK	2366	Q09666
GKWKSPKFKMPEMHF	AHNAK	2816	Q09666
DWHLKMPKVKMPKFS	AHNAK	4311	Q09666
MAVIVDKPWFYDMKK	CERS2	151	Q96G23
DEKWKMSPSLFLPAM	IQCA1	381	Q86XH1
DDLPKWMKMIDKYAS	RAB12	131	Q6IQ22
KMKKWEDMANLPPHF	RBL2	131	Q08999
FMAKIYNKDPMDWPE	MAGEE1	671	Q9HCI5
MKPLLQMKKWCEYFI	DDX60	341	Q8IY21
PMKMKNYNKPWEPKW	MT-ATP8	41	P03928
PKSWLMKALFKTFYM	ABCC2	306	Q92887
YDIKLNEWKMVSPMP	KLHL7	501	Q8IXQ5
MKIKDAKKPSFPWFG	PANK3	1	Q9H999
PVMDLKAFPKDNMLW	IL6ST	426	P40189
KYDPGANKWMMVAPL	KLHL25	416	Q9H0H3
KIMMKCWDYKPENRP	FER	791	P16591
HGMKMPFNKEPKWLF	CHKA	236	P35790
KIPEMWMGKSYPSLK	DNAH7	3831	Q8WXX0
PAADMKYMIWDKGLA	GLIPR1L1	51	Q6UWM5
KWGPMKEPTIKFYTK	MAP3K15	741	Q6ZN16
YPSKSEKLWSMEKMK	MCM9	511	Q9NXL9
MFYAPWSKKCKMLFP	PDILT	411	Q8N807
KFYLFPLKMITWTMP	TAS2R60	191	P59551
WSVPKFMKRMKVPDY	STARD13	641	Q9Y3M8
SSIPMEYAKMWKPGD	TDRD3	546	Q9H7E2
DKYQAWPMPRMFSKA	SAXO1	276	Q8IYX7
MMDADPKWPYFIQYK	FER1L5	1856	A0AVI2
GPMIYWMKGEKFIEE	IL1RAPL2	276	Q9NP60
CKYMDSKMKPLWLVY	PIK3CB	776	P42338
MPLFGWMKWPKNDSY	RD3L	1	P0DJH9
FLPKMPWSITEKDMK	DIS3	451	Q9Y2L1
MYWYKQKAKKPPELM	TRBV4-1	51	A0A577
MNDWMPIAKEYDPLK	SNRNP35	1	Q16560
LQMLWFKYLSPPKLM	VN1R5	331	Q7Z5H4
HSMPETCQWPEKMKY	TLR2	426	O60603
EPWMMEKKLSKAYPF	ZNF302	61	Q9NR11