Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	FA58C	CNTNAP3B CNTNAP3 CNTNAP4	9.17e-05	21	79	3	SM00231
Domain	FA58C_3	CNTNAP3B CNTNAP3 CNTNAP4	9.17e-05	21	79	3	PS50022
Domain	FA58C_1	CNTNAP3B CNTNAP3 CNTNAP4	9.17e-05	21	79	3	PS01285
Domain	FA58C_2	CNTNAP3B CNTNAP3 CNTNAP4	9.17e-05	21	79	3	PS01286
Domain	F5_F8_type_C	CNTNAP3B CNTNAP3 CNTNAP4	1.38e-04	24	79	3	PF00754
Domain	FA58C	CNTNAP3B CNTNAP3 CNTNAP4	1.38e-04	24	79	3	IPR000421
Domain	Pkinase_Tyr	JAK3 KSR1 CSK TEX14 PLK4	2.18e-04	129	79	5	PF07714
Domain	Xpo1	IPO13 TNPO3	2.62e-04	6	79	2	PF08389
Domain	Exportin-1/Importin-b-like	IPO13 TNPO3	2.62e-04	6	79	2	IPR013598
Domain	Ser-Thr/Tyr_kinase_cat_dom	JAK3 KSR1 CSK TEX14 PLK4	2.98e-04	138	79	5	IPR001245
Domain	FIBRINOGEN_C_1	CNTNAP3B CNTNAP3 CNTNAP4	3.31e-04	32	79	3	PS00514
Domain	Fibrinogen_a/b/g_C_dom	CNTNAP3B CNTNAP3 CNTNAP4	3.31e-04	32	79	3	IPR002181
Domain	FIBRINOGEN_C_2	CNTNAP3B CNTNAP3 CNTNAP4	3.31e-04	32	79	3	PS51406
Domain	LAM_G_DOMAIN	CNTNAP3B CNTNAP3 CNTNAP4	5.52e-04	38	79	3	PS50025
Domain	Laminin_G_2	CNTNAP3B CNTNAP3 CNTNAP4	6.43e-04	40	79	3	PF02210
Domain	Galactose-bd-like	CNTNAP3B CNTNAP3 CNTNAP4 NGLY1	6.77e-04	94	79	4	IPR008979
Domain	LamG	CNTNAP3B CNTNAP3 CNTNAP4	8.51e-04	44	79	3	SM00282
Domain	Laminin_G	CNTNAP3B CNTNAP3 CNTNAP4	1.90e-03	58	79	3	IPR001791
Domain	VWD	MUC6 VWDE	2.04e-03	16	79	2	SM00216
Domain	VWF_type-D	MUC6 VWDE	2.04e-03	16	79	2	IPR001846
Domain	VWFD	MUC6 VWDE	2.04e-03	16	79	2	PS51233
Domain	VWD	MUC6 VWDE	2.04e-03	16	79	2	PF00094
Domain	-	IPO13 ULK4 TTI1 PSMD2 TNPO3	2.50e-03	222	79	5	1.25.10.10
Domain	ARM-type_fold	USP34 IPO13 ULK4 TTI1 PSMD2 TNPO3	3.13e-03	339	79	6	IPR016024
Domain	Prot_kinase_dom	JAK3 KSR1 CSK ULK4 TEX14 MELK PLK4	4.62e-03	489	79	7	IPR000719
Domain	PROTEIN_KINASE_DOM	JAK3 KSR1 CSK ULK4 TEX14 MELK PLK4	4.83e-03	493	79	7	PS50011
Domain	ARM-like	IPO13 ULK4 TTI1 PSMD2 TNPO3	5.75e-03	270	79	5	IPR011989
Domain	FBG	CNTNAP3 CNTNAP4	6.66e-03	29	79	2	SM00186
Domain	-	CNTNAP3 CNTNAP4	7.12e-03	30	79	2	3.90.215.10
Domain	Fibrinogen_a/b/g_C_1	CNTNAP3 CNTNAP4	7.12e-03	30	79	2	IPR014716
Domain	Kinase-like_dom	JAK3 KSR1 CSK ULK4 TEX14 MELK PLK4	7.99e-03	542	79	7	IPR011009
Domain	PROTEIN_KINASE_TYR	JAK3 CSK PLK4	8.08e-03	97	79	3	PS00109
Domain	Tyr_kinase_AS	JAK3 CSK PLK4	8.08e-03	97	79	3	IPR008266
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PCNX2 JAK3 USP34 TKFC GAREM2 ATP13A1 DGKQ ULK4 TNPO3 ABTB2 ABCC10 TIAM2 CABLES1	1.83e-06	1105	82	13	35748872
Pubmed	The critical role of ASD-related gene CNTNAP3 in regulating synaptic development and social behavior in mice.	CNTNAP3B CNTNAP3	5.49e-06	2	82	2	31150793
Pubmed	Caspr3-Deficient Mice Exhibit Low Motor Learning during the Early Phase of the Accelerated Rotarod Task.	CNTNAP3B CNTNAP3	5.49e-06	2	82	2	26807827
Pubmed	Cell adhesion molecule contactin-associated protein 3 is expressed in the mouse basal ganglia during early postnatal stages.	CNTNAP3B CNTNAP3 CNTNAP4	8.39e-06	17	82	3	26389685
Pubmed	Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease.	DDX60L ST8SIA1 PZP	1.63e-05	21	82	3	20708005
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	CSK PSMB7 TTI1 GNB2 TNPO3 RCC2 HNRNPD KDM1A	2.36e-05	498	82	8	36634849
Pubmed	Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.	JAK3 KSR1 CSK GRM2 HNRNPD KDM1A	5.00e-05	276	82	6	28319085
Pubmed	Caspr3 and caspr4, two novel members of the caspr family are expressed in the nervous system and interact with PDZ domains.	CNTNAP3 CNTNAP4	5.47e-05	5	82	2	12093160
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	IPO13 RNF213 TTI1 PSMD2 TNPO3	7.51e-05	183	82	5	23956138
Pubmed	In trans neuregulin3-Caspr3 interaction controls DA axonal bassoon cluster development.	CNTNAP3B CNTNAP3	8.19e-05	6	82	2	34143959
Pubmed	SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis.	TUBA8 KIF22	1.14e-04	7	82	2	11146551
Pubmed	FBXL2 is a ubiquitin E3 ligase subunit that triggers mitotic arrest.	FBXL2 PLK4	1.52e-04	8	82	2	22024926
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	USP34 CNTNAP3B TKFC PDPR ATP13A1 CNTNAP3 IPO13 RNF213 TTI1 ABCC10	1.96e-04	1061	82	10	33845483
Pubmed	Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.	PCNX2 MARF1 TTI1	2.57e-04	52	82	3	9455477
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	USP34 PDPR IPO13 MELK RCC2 KDM1A TIAM2	2.57e-04	529	82	7	14621295
Pubmed	Recapitulation of two genomewide association studies on blood pressure and essential hypertension in the Korean population.	CSK ULK4	3.57e-04	12	82	2	20414254
Pubmed	Coordinated regulation of the ribosome and proteasome by PRMT1 in the maintenance of neural stemness in cancer cells and neural stem cells.	PSMD2 KDM1A	4.21e-04	13	82	2	34619150
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	USP34 CSK PSMB7 PSMD2 NGLY1 TNPO3 RCC2 ABTB2 KDM1A	4.81e-04	974	82	9	28675297
Pubmed	Alternative exon skipping biases substrate preference of the deubiquitylase USP15 for mysterin/RNF213, the moyamoya disease susceptibility factor.	PSMB7 RNF213 PSMD2	4.97e-04	65	82	3	28276505
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	IGSF8 USP34 PSMB7 IPO13 RNF213 PSMD2 DDX60L GNB2 TNPO3 RCC2 HNRNPD	5.57e-04	1440	82	11	30833792
Pubmed	p62-Dependent Phase Separation of Patient-Derived KEAP1 Mutations and NRF2.	PSMD2 PALB2	5.65e-04	15	82	2	30126895
Pubmed	A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias.	JAK3 CSK	6.45e-04	16	82	2	19464057
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	USP34 TKFC ATP13A1 PSMB7 KYAT3 TNPO3	7.51e-04	457	82	6	32344865
Pubmed	Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study.	CSK ULK4	8.20e-04	18	82	2	21045733
Pubmed	Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.	JAK3 TATDN2 TTI1 PSMD2 LARGE1	8.86e-04	313	82	5	20800603
Pubmed	Genome-wide association study of blood pressure and hypertension.	CSK ULK4	9.15e-04	19	82	2	19430479
Pubmed	The N6-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2.	IGSF8 TKFC TTC28 CTHRC1 KIF22	1.05e-03	325	82	5	36168628
Pubmed	FoxP1 orchestration of ASD-relevant signaling pathways in the striatum.	CNTNAP3B CNTNAP3	1.23e-03	22	82	2	26494785
Pubmed	Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity.	PSMB7 RNF213 PSMD2	1.54e-03	96	82	3	34599178
Pubmed	A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.	CSK TNPO3	1.86e-03	27	82	2	23740937
Pubmed	A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes.	PSMB7 PSMD2	1.86e-03	27	82	2	16990800
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	USP34 KDM1A LARGE1	1.99e-03	105	82	3	9628581
Pubmed	The protein kinase complement of the human genome.	ULK4 TEX14	1.99e-03	28	82	2	12471243
Pubmed	Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins.	PSMB7 DGKQ	1.99e-03	28	82	2	20736409
Pubmed	A protein-protein interaction network of transcription factors acting during liver cell proliferation.	CSK GNB2	2.14e-03	29	82	2	18255255
Pubmed	Zfhx3 is required for the differentiation of late born D1-type medium spiny neurons.	CNTNAP3B CNTNAP3	2.14e-03	29	82	2	31491374
Pubmed	A genetic approach to Mammalian glycan function.	ST8SIA1 LARGE1	2.29e-03	30	82	2	12676797
Pubmed	Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.	GAREM2 ARFIP2 KDM1A	2.33e-03	111	82	3	22558309
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like-AT1_Progenitor\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BTG2 SCMH1 CD300LG FBXL2 ABCC10 KIF22	4.61e-07	157	82	6	a93866f051472506f1468f379c0d5313e02c9731
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma-5\|TCGA-Brain / Sample_Type by Project: Shred V9	GAREM2 CD300LG MCMDC2 USH1C ABTB2	5.50e-06	137	82	5	a7c76201b8901b2ef7ebbb4dfe0cec0dc4534ef5
Disease	autosomal recessive intellectual developmental disorder (implicated_via_orthology)	CNTNAP3B CNTNAP3 CNTNAP4	9.11e-07	8	76	3	DOID:0060308 (implicated_via_orthology)
Disease	pappalysin-1 measurement	USP34 PSMD2	9.75e-05	6	76	2	EFO_0802845
Disease	breast ductal carcinoma (is_marker_for)	EBAG9 PLK4	1.81e-04	8	76	2	DOID:3007 (is_marker_for)
Disease	proteoglycan 3 measurement	USP34 PSMD2	1.81e-04	8	76	2	EFO_0802970
Disease	non-alcoholic fatty liver disease, cirrhosis of liver	DDX60L ST8SIA1 PZP	3.51e-04	53	76	3	EFO_0001422, EFO_0003095
Disease	Sjogren syndrome	MEI4 DGKQ TNPO3	5.06e-04	60	76	3	EFO_0000699
Disease	Paroxysmal atrial fibrillation	USP34 SCMH1 PSMB7 TUBA8	7.17e-04	156	76	4	C0235480
Disease	familial atrial fibrillation	USP34 SCMH1 PSMB7 TUBA8	7.17e-04	156	76	4	C3468561
Disease	Persistent atrial fibrillation	USP34 SCMH1 PSMB7 TUBA8	7.17e-04	156	76	4	C2585653
Disease	Atrial Fibrillation	USP34 SCMH1 PSMB7 TUBA8	7.89e-04	160	76	4	C0004238
Disease	pulse pressure measurement	USP34 PDPR TTC28 PSMB7 RNF213 ULK4 KYAT3 MYEOV GNB2 ABCC10 KDM1A	8.46e-04	1392	76	11	EFO_0005763
Disease	limited scleroderma	DGKQ TNPO3	1.09e-03	19	76	2	EFO_1001017
Disease	cardiovascular disease	USP34 MEI4 CSK KYAT3 MYEOV ABCC10	1.17e-03	457	76	6	EFO_0000319
Disease	systemic scleroderma	CSK DGKQ TNPO3	1.39e-03	85	76	3	EFO_0000717
Disease	Dwarfism	AMMECR1 PLK4	1.89e-03	25	76	2	C0013336
Disease	Calcium channel blocker use measurement	USP34 CSK RNF213 ABCC10	2.26e-03	213	76	4	EFO_0009930

Protein segments in the cluster

Peptide	Gene	Start	Entry
KVFISLVGSRGLGCS	USH1C	211	Q9Y6N9
RCDAAFIIGSGRKSL	URB2	701	Q14146
TATRQRGFLGCIRSL	CNTNAP3	921	Q9BZ76
ALRVLFSGSLRLKCR	CTHRC1	136	Q96CG8
GLLLAGCFLFISRSK	ATP13A1	1021	Q9HD20
VCTLRRLGLGTAFSV	GRM2	631	Q14416
TATRQRGFLGCIRSL	CNTNAP4	921	Q9C0A0
KSGGLKGRDLLCSFR	DGKQ	596	P52824
RGKSARCGLTFSVGR	BTBD11	201	A6QL63
RGRSVLGGDCLLKFS	CSK	281	P41240
CTKQLLSERFGRGSR	ARFIP2	106	P53365
ATVFSFLKRLICRSG	EBAG9	16	O00559
RIRSLACGKSSIIVA	RCC2	431	Q9P258
GLATVSLCRKLSRVL	PZP	261	P20742
KGCLIRRSPTGTFLL	JAK3	426	P52333
RLGRYRCEKGTTAVL	PSMB7	241	Q99436
RGKPVRLRLSSFSCG	MELK	326	Q14680
GVTCSRAIKIFLGGL	MUC6	921	Q6W4X9
RTGSGKSSLLLVLFR	ABCC10	1281	Q5T3U5
NISKRCGGFLRKLSL	FBXL2	71	Q9UKC9
ALRKVLGRCGSSQSI	OR2T2	301	Q6IF00
RGRRKFLAASLSLLC	LARGE1	6	O95461
RIRTGSVCGSKLSAS	MCMDC2	571	Q4G0Z9
SKCGGQTRSRDRSLL	NGLY1	251	Q96IV0
RFTKTLPAGRTLCGA	DDX60L	811	Q5H9U9
RKLSRTGLVGLGLSC	MFSD6L	426	Q8IWD5
LVTLSFALCTLGRRA	PCNX2	1626	A6NKB5
FALCTLGRRALGTAA	PCNX2	1631	A6NKB5
SIGSLRGLRTKCAVS	KSR1	51	Q8IVT5
RVKSTAGRRKAFGTC	OR2Y1	226	Q8NGV0
ILIGVRCRSSSGSSK	OR4K1	221	Q8NGD4
AISGAGRCRLSKIGA	KIF22	21	Q14807
RLAAGSTRFCAGILS	PDPR	76	Q8NCN5
LTAARKLAGATGRRC	DECR2	66	Q9NUI1
SKAGRSRGRLCLSQA	MYEOV	71	Q96EZ4
CGITSVAFSRSGRLL	GNB2	271	P62879
GSFVALLSKCLRGAA	PCDHGC4	706	Q9Y5F7
FGEICLLTRGRRTAS	HCN3	491	Q9P1Z3
DCVFGTDSLRLSGKR	PALB2	161	Q86YC2
SFGLKTLLARGAIVR	PPT2	261	Q9UMR5
CLAKAYVRGSGTRLR	IGSF8	406	Q969P0
RCLAILKGIFGSSAV	KDM1A	726	O60341
TRFSLLAAAERGGCI	CABLES1	106	Q8TDN4
GRIVLISGRRSFCSI	CABLES1	336	Q8TDN4
FVSKRRFILKTCGTT	AMD1	71	P17707
GKVLSITGCSAILRF	MARF1	541	Q9Y4F3
KRLTLSGICAFISGR	FOXD4L1	126	Q9NU39
TSILQRGCSKFRLLG	HGSNAT	326	Q68CP4
RRSLTAKTLACLLVG	B3GNT6	6	Q6ZMB0
RGSLLGCFIDTRSAA	CAPN9	226	O14815
RFASGSKIVLTRLCV	IPO13	111	O94829
RSLCSLSGRAKFLKT	KYAT3	6	Q6YP21
TATRQRGFLGCIRSL	CNTNAP3B	921	Q96NU0
GRTESRSSGLKLAAC	RP1	371	P56715
CTLKLDPITGRSRGF	HNRNPD	126	Q14103
FTTLLRKLGRAGALA	GAREM2	171	Q75VX8
LRQKLLVSRLCSGSF	MEI4	61	A8MW99
AASKGCLIRNTRGFL	TATDN2	96	Q93075
RLTGLKRLSSFIGAG	TEX14	1281	Q8IWB6
SALLRCALGVFRKFS	PSMD2	246	Q13200
KRLSTGLFLVSAALG	ST8SIA1	271	Q92185
SISGSLFDKRRLLIG	PLK4	301	O00444
SAVRRLCSRGVLKGS	SCMH1	541	Q96GD3
VIGFLGCLCGVSKRR	TM4SF20	211	Q53R12
DGLRRGKSARCGLTF	ABTB2	191	Q8N961
GRIGCKVLSFIRLTS	BRS3	116	P32247
AVGFLSSLLRTRGCV	BTG2	16	P78543
IGRDKRLRGCIGTFS	AMMECR1	166	Q9Y4X0
CRKGGILFSRCSGTI	CD300LG	51	Q6UXG3
VNRCLFIKSSLLGSG	RNF213	476	Q63HN8
NSSIGRLCLAFLGKR	VWDE	816	Q8N2E2
KLALGRLGILSVSSF	TIAM2	721	Q8IVF5
TCVVRFAKTGALRGA	SPRED3	236	Q2MJR0
LCSNGTFRELRLVKG	SCART1	126	Q4G0T1
CSGLVILLIFRRTSG	TRAV18	6	A0A075B6X5
LRFAVRCVGKGSAAL	TNPO3	666	Q9Y5L0
KRCGRAFSVSSSLRI	ZNF442	296	Q9H7R0
GTCSLKLRGSVFSAL	TTC28	226	Q96AY4
IGGRSCVTRFVRTLL	USP34	2411	Q70CQ2
SAFTVLKKAGRRGLC	TKFC	141	Q3LXA3
KECGRAFSRGSELTL	ZNF571	561	Q7Z3V5
RIRKLTDACSGLQGF	TUBA8	121	Q9NY65
GRRKGTINFVAILCT	ULK4	21	Q96C45
KVLRTLGSKCGDFLR	TTI1	931	O43156
DASRRLCGFLKSLGV	NARF	116	Q9UHQ1