Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1C CACNA1D CACNA1F CACNA1G	1.69e-07	14	74	4	GO:0008331
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in cardiac muscle cell action potential	CACNA1C CACNA1D CACNA1G	4.86e-07	5	74	3	GO:0086007
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved SA node cell action potential	CACNA1D CACNA1G	1.35e-05	2	74	2	GO:0086059
GeneOntologyMolecularFunction	ATP-dependent activity	KATNAL2 FBH1 ATRX SHPRH ATP1A4 DNAH5 DNAH6 ATP4A DYNC1I1 ABCC10 DYNC1I2	1.53e-05	614	74	11	GO:0140657
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1C CACNA1D CACNA1F CACNA1G	2.52e-05	46	74	4	GO:0005245
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in AV node cell action potential	CACNA1C CACNA1G	4.05e-05	3	74	2	GO:0086056
GeneOntologyMolecularFunction	cytoskeletal motor activity	GPR88 DNAH5 DNAH6 DYNC1I1 DYNC1I2	7.70e-05	118	74	5	GO:0003774
GeneOntologyMolecularFunction	microtubule motor activity	DNAH5 DNAH6 DYNC1I1 DYNC1I2	1.32e-04	70	74	4	GO:0003777
GeneOntologyMolecularFunction	DNA translocase activity	FBH1 ATRX	1.35e-04	5	74	2	GO:0015616
GeneOntologyMolecularFunction	ATP hydrolysis activity	KATNAL2 FBH1 ATRX ATP1A4 DNAH5 DNAH6 ATP4A ABCC10	2.24e-04	441	74	8	GO:0016887
GeneOntologyMolecularFunction	P-type sodium transporter activity	ATP1A4 ATP4A	5.98e-04	10	74	2	GO:0008554
GeneOntologyMolecularFunction	P-type sodium:potassium-exchanging transporter activity	ATP1A4 ATP4A	5.98e-04	10	74	2	GO:0005391
GeneOntologyMolecularFunction	P-type potassium transmembrane transporter activity	ATP1A4 ATP4A	7.29e-04	11	74	2	GO:0008556
GeneOntologyMolecularFunction	dynein light chain binding	DYNC1I1 DYNC1I2	8.73e-04	12	74	2	GO:0045503
GeneOntologyMolecularFunction	calcium channel activity	CACNA1C CACNA1D CACNA1F CACNA1G	1.35e-03	129	74	4	GO:0005262
GeneOntologyMolecularFunction	dynein heavy chain binding	DYNC1I1 DYNC1I2	1.78e-03	17	74	2	GO:0045504
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH5 DNAH6	1.99e-03	18	74	2	GO:0008569
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	KATNAL2 FBH1 ATRX ATP1A4 RAP2C DNAH5 DNAH6 ATP4A ABCC10	2.21e-03	775	74	9	GO:0017111
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNA1C CACNA1D CACNA1F CACNA1G	2.40e-03	151	74	4	GO:0015085
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	CACNA1C CACNA1D CACNA1F CACNA1G	2.46e-03	152	74	4	GO:0022843
GeneOntologyMolecularFunction	pyrophosphatase activity	KATNAL2 FBH1 ATRX ATP1A4 RAP2C DNAH5 DNAH6 ATP4A ABCC10	3.75e-03	839	74	9	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	KATNAL2 FBH1 ATRX ATP1A4 RAP2C DNAH5 DNAH6 ATP4A ABCC10	3.78e-03	840	74	9	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	KATNAL2 FBH1 ATRX ATP1A4 RAP2C DNAH5 DNAH6 ATP4A ABCC10	3.78e-03	840	74	9	GO:0016818
GeneOntologyBiologicalProcess	inorganic ion import across plasma membrane	CACNA1C CACNA1D CACNA1F CACNA1G ATP1A4 ATP4A	1.12e-05	142	73	6	GO:0099587
GeneOntologyBiologicalProcess	inorganic cation import across plasma membrane	CACNA1C CACNA1D CACNA1F CACNA1G ATP1A4 ATP4A	1.12e-05	142	73	6	GO:0098659
GeneOntologyBiologicalProcess	calcium ion import across plasma membrane	CACNA1C CACNA1D CACNA1F CACNA1G	2.50e-05	48	73	4	GO:0098703
GeneOntologyBiologicalProcess	calcium ion import into cytosol	CACNA1C CACNA1D CACNA1F CACNA1G	2.50e-05	48	73	4	GO:1902656
GeneOntologyBiologicalProcess	regulation of membrane depolarization	CACNA1C CACNA1D NEDD4L CACNA1G	6.47e-05	61	73	4	GO:0003254
GeneOntologyBiologicalProcess	cardiac muscle cell action potential involved in contraction	CACNA1C CACNA1D NEDD4L CACNA1G	6.90e-05	62	73	4	GO:0086002
GeneOntologyBiologicalProcess	membrane depolarization	CACNA1C CACNA1D NEDD4L CACNA1G CHRNE	6.98e-05	121	73	5	GO:0051899
GeneOntologyBiologicalProcess	membrane depolarization during cardiac muscle cell action potential	CACNA1C CACNA1D CACNA1G	7.16e-05	23	73	3	GO:0086012
GeneOntologyBiologicalProcess	membrane depolarization during SA node cell action potential	CACNA1D CACNA1G	1.23e-04	5	73	2	GO:0086046
GeneOntologyBiologicalProcess	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	CACNA1C CACNA1D	1.23e-04	5	73	2	GO:1904879
GeneOntologyBiologicalProcess	import across plasma membrane	CACNA1C CACNA1D CACNA1F CACNA1G ATP1A4 ATP4A	1.64e-04	230	73	6	GO:0098739
GeneOntologyBiologicalProcess	membrane depolarization during AV node cell action potential	CACNA1C CACNA1G	1.84e-04	6	73	2	GO:0086045
GeneOntologyBiologicalProcess	cell-cell signaling involved in cardiac conduction	CACNA1C CACNA1D CACNA1G	2.35e-04	34	73	3	GO:0086019
GeneOntologyBiologicalProcess	cardiac muscle cell action potential	CACNA1C CACNA1D NEDD4L CACNA1G	2.57e-04	87	73	4	GO:0086001
GeneOntologyBiologicalProcess	membrane depolarization during action potential	CACNA1C CACNA1D CACNA1G	2.79e-04	36	73	3	GO:0086010
GeneOntologyBiologicalProcess	cardiac muscle cell contraction	CACNA1C CACNA1D NEDD4L CACNA1G	3.32e-04	93	73	4	GO:0086003
GeneOntologyBiologicalProcess	calcium ion import	CACNA1C CACNA1D CACNA1F CACNA1G	4.06e-04	98	73	4	GO:0070509
GeneOntologyBiologicalProcess	regulation of heart rate by cardiac conduction	CACNA1C CACNA1D CACNA1G	4.12e-04	41	73	3	GO:0086091
GeneOntologyBiologicalProcess	SA node cell to atrial cardiac muscle cell signaling	CACNA1D CACNA1G	5.46e-04	10	73	2	GO:0086018
GeneOntologyBiologicalProcess	SA node cell action potential	CACNA1D CACNA1G	5.46e-04	10	73	2	GO:0086015
GeneOntologyCellularComponent	voltage-gated calcium channel complex	CACNA1C CACNA1D CACNA1F CACNA1G	2.11e-05	46	74	4	GO:0005891
GeneOntologyCellularComponent	microtubule associated complex	KATNAL2 HAUS5 DNAH5 DNAH6 DYNC1I1 DYNC1I2	2.29e-05	161	74	6	GO:0005875
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	ZSWIM5 ZSWIM4 PRAMEF26 PRAMEF6	2.30e-05	47	74	4	GO:0031462
GeneOntologyCellularComponent	dynein complex	DNAH5 DNAH6 DYNC1I1 DYNC1I2	4.00e-05	54	74	4	GO:0030286
GeneOntologyCellularComponent	axonemal dynein complex	DNAH5 DNAH6 DYNC1I2	9.26e-05	25	74	3	GO:0005858
GeneOntologyCellularComponent	calcium channel complex	CACNA1C CACNA1D CACNA1F CACNA1G	1.31e-04	73	74	4	GO:0034704
GeneOntologyCellularComponent	L-type voltage-gated calcium channel complex	CACNA1C CACNA1D	7.97e-04	12	74	2	GO:1990454
GeneOntologyCellularComponent	outer dynein arm	DNAH5 DYNC1I2	7.97e-04	12	74	2	GO:0036157
GeneOntologyCellularComponent	cullin-RING ubiquitin ligase complex	FBH1 ZSWIM5 ZSWIM4 PRAMEF26 PRAMEF6	9.34e-04	212	74	5	GO:0031461
GeneOntologyCellularComponent	presynaptic active zone	CACNA1D CELSR3 TRIO ZZEF1	1.58e-03	141	74	4	GO:0048786
Domain	VDCCAlpha1	CACNA1C CACNA1D CACNA1F CACNA1G	4.19e-08	10	72	4	IPR002077
Domain	CAC1F_C	CACNA1C CACNA1D CACNA1F	5.49e-08	3	72	3	IPR031688
Domain	CAC1F_C	CACNA1C CACNA1D CACNA1F	5.49e-08	3	72	3	PF16885
Domain	VDCC_L_a1su	CACNA1C CACNA1D CACNA1F	2.19e-07	4	72	3	IPR005446
Domain	VDCC_a1su_IQ	CACNA1C CACNA1D CACNA1F	1.90e-06	7	72	3	IPR014873
Domain	GPHH	CACNA1C CACNA1D CACNA1F	1.90e-06	7	72	3	PF16905
Domain	GPHH_dom	CACNA1C CACNA1D CACNA1F	1.90e-06	7	72	3	IPR031649
Domain	Ca_chan_IQ	CACNA1C CACNA1D CACNA1F	1.90e-06	7	72	3	SM01062
Domain	Ca_chan_IQ	CACNA1C CACNA1D CACNA1F	1.90e-06	7	72	3	PF08763
Domain	DYNC1I1/DYNC1I2	DYNC1I1 DYNC1I2	1.47e-05	2	72	2	IPR025956
Domain	Dynein_IC2	DYNC1I1 DYNC1I2	1.47e-05	2	72	2	PF11540
Domain	Channel_four-helix_dom	CACNA1C CACNA1D CACNA1F CACNA1G	6.87e-05	57	72	4	IPR027359
Domain	-	CACNA1C CACNA1D CACNA1F CACNA1G	6.87e-05	57	72	4	1.20.120.350
Domain	P-type_ATPase_IIC	ATP1A4 ATP4A	2.18e-04	6	72	2	IPR005775
Domain	APC_su10/DOC_dom	HERC2 ZZEF1	3.04e-04	7	72	2	IPR004939
Domain	DOC	HERC2 ZZEF1	3.04e-04	7	72	2	PS51284
Domain	SWIM	ZSWIM5 ZSWIM4	3.04e-04	7	72	2	PF04434
Domain	APC10	HERC2 ZZEF1	3.04e-04	7	72	2	SM01337
Domain	ANAPC10	HERC2 ZZEF1	3.04e-04	7	72	2	PF03256
Domain	Znf_SWIM	ZSWIM5 ZSWIM4	5.18e-04	9	72	2	IPR007527
Domain	ZF_SWIM	ZSWIM5 ZSWIM4	5.18e-04	9	72	2	PS50966
Domain	Ion_trans_dom	CACNA1C CACNA1D CACNA1F CACNA1G	9.84e-04	114	72	4	IPR005821
Domain	Ion_trans	CACNA1C CACNA1D CACNA1F CACNA1G	9.84e-04	114	72	4	PF00520
Domain	Dynein_heavy_chain_D4_dom	DNAH5 DNAH6	1.29e-03	14	72	2	IPR024317
Domain	Dynein_HC_stalk	DNAH5 DNAH6	1.29e-03	14	72	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH5 DNAH6	1.29e-03	14	72	2	IPR013602
Domain	DHC_N2	DNAH5 DNAH6	1.29e-03	14	72	2	PF08393
Domain	MT	DNAH5 DNAH6	1.29e-03	14	72	2	PF12777
Domain	AAA_8	DNAH5 DNAH6	1.29e-03	14	72	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH5 DNAH6	1.29e-03	14	72	2	IPR011704
Domain	AAA_5	DNAH5 DNAH6	1.29e-03	14	72	2	PF07728
Domain	DHC_fam	DNAH5 DNAH6	1.49e-03	15	72	2	IPR026983
Domain	Dynein_heavy_dom	DNAH5 DNAH6	1.49e-03	15	72	2	IPR004273
Domain	Dynein_heavy	DNAH5 DNAH6	1.49e-03	15	72	2	PF03028
Domain	-	ATP1A4 ATP4A	1.70e-03	16	72	2	1.20.1110.10
Domain	ATPase_P-typ_TM_dom	ATP1A4 ATP4A	1.70e-03	16	72	2	IPR023298
Domain	PH	TRIO PLEKHG4 SPTBN2 OSBPL8 FERMT3	1.90e-03	229	72	5	PF00169
Domain	ATPase_P-typ_cation-transptr_C	ATP1A4 ATP4A	1.92e-03	17	72	2	IPR006068
Domain	Cation_ATPase_C	ATP1A4 ATP4A	1.92e-03	17	72	2	PF00689
Domain	ZZ	HERC2 ZZEF1	2.15e-03	18	72	2	PF00569
Domain	Cation_ATPase_N	ATP1A4 ATP4A	2.15e-03	18	72	2	PF00690
Domain	Cation_ATPase_N	ATP1A4 ATP4A	2.15e-03	18	72	2	SM00831
Domain	ZF_ZZ_2	HERC2 ZZEF1	2.15e-03	18	72	2	PS50135
Domain	ZF_ZZ_1	HERC2 ZZEF1	2.15e-03	18	72	2	PS01357
Domain	-	KATNAL2 FBH1 ATRX SHPRH RAP2C DNAH5 DNAH6 ABCC10 NLRP13	2.21e-03	746	72	9	3.40.50.300
Domain	AAA+_ATPase	KATNAL2 DNAH5 DNAH6 ABCC10	2.32e-03	144	72	4	IPR003593
Domain	AAA	KATNAL2 DNAH5 DNAH6 ABCC10	2.32e-03	144	72	4	SM00382
Domain	Znf_ZZ	HERC2 ZZEF1	2.40e-03	19	72	2	IPR000433
Domain	ATPase_P-typ_cation-transptr_N	ATP1A4 ATP4A	2.40e-03	19	72	2	IPR004014
Domain	ZnF_ZZ	HERC2 ZZEF1	2.40e-03	19	72	2	SM00291
Domain	-	EPHA2 HERC2 ZZEF1	2.82e-03	73	72	3	2.60.120.260
Domain	Spectrin	TRIO SPTBN2	3.52e-03	23	72	2	PF00435
Domain	WD40_repeat	WDR87 HERC2 WDFY4 DYNC1I1 DYNC1I2	3.99e-03	272	72	5	IPR001680
Domain	PH	TRIO PLEKHG4 SPTBN2 OSBPL8 FERMT3	4.38e-03	278	72	5	SM00233
Domain	WD_REPEATS_1	WDR87 HERC2 WDFY4 DYNC1I1 DYNC1I2	4.38e-03	278	72	5	PS00678
Domain	WD_REPEATS_2	WDR87 HERC2 WDFY4 DYNC1I1 DYNC1I2	4.44e-03	279	72	5	PS50082
Domain	WD_REPEATS_REGION	WDR87 HERC2 WDFY4 DYNC1I1 DYNC1I2	4.44e-03	279	72	5	PS50294
Domain	PH_DOMAIN	TRIO PLEKHG4 SPTBN2 OSBPL8 FERMT3	4.44e-03	279	72	5	PS50003
Domain	PH_domain	TRIO PLEKHG4 SPTBN2 OSBPL8 FERMT3	4.51e-03	280	72	5	IPR001849
Domain	HECT	NEDD4L HERC2	4.83e-03	27	72	2	PF00632
Domain	HECTc	NEDD4L HERC2	4.83e-03	27	72	2	SM00119
Domain	HECT_dom	NEDD4L HERC2	4.83e-03	27	72	2	IPR000569
Domain	HECT	NEDD4L HERC2	4.83e-03	27	72	2	PS50237
Domain	P-loop_NTPase	KATNAL2 FBH1 ATRX SHPRH RAP2C DNAH5 DNAH6 ABCC10 NLRP13	5.15e-03	848	72	9	IPR027417
Domain	CRAL-TRIO_dom	TRIO PLEKHG4	5.19e-03	28	72	2	IPR001251
Domain	Spectrin_repeat	TRIO SPTBN2	5.56e-03	29	72	2	IPR002017
Domain	Galactose-bd-like	EPHA2 HERC2 ZZEF1	5.73e-03	94	72	3	IPR008979
Domain	PH_dom-like	TRIO PLEKHG4 SPTBN2 OSBPL8 WDFY4 FERMT3	5.98e-03	426	72	6	IPR011993
Domain	SNF2_N	ATRX SHPRH	6.75e-03	32	72	2	IPR000330
Domain	Spectrin/alpha-actinin	TRIO SPTBN2	6.75e-03	32	72	2	IPR018159
Domain	-	ATP1A4 ATP4A	6.75e-03	32	72	2	3.40.1110.10
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1C CACNA1D CACNA1F	7.84e-07	6	49	3	M47762
Pathway	KEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1C CACNA1D CACNA1F CACNA1G	1.09e-06	23	49	4	M47666
Pathway	KEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL	CACNA1C CACNA1D CACNA1F CACNA1G	1.54e-06	25	49	4	M47948
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_VGCC_CA2_APOPTOTIC_PATHWAY_N01004	CACNA1C CACNA1D CACNA1F	1.40e-05	14	49	3	M47692
Pathway	REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH	CACNA1C CACNA1D SPTBN2 CACNA1G	6.60e-05	63	49	4	M11187
Pathway	KEGG_CARDIAC_MUSCLE_CONTRACTION	CACNA1C CACNA1D CACNA1F ATP1A4	1.60e-04	79	49	4	M17673
Pathway	REACTOME_NCAM1_INTERACTIONS	CACNA1C CACNA1D CACNA1G	4.12e-04	42	49	3	M7169
Pubmed	Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.	CACNA1C CACNA1D CACNA1F CACNA1G	7.33e-10	7	76	4	12900400
Pubmed	Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response.	CACNA1C CACNA1D CACNA1F	4.00e-08	4	76	3	20937870
Pubmed	Multiple mouse chromosomal loci for dynein-based motility.	NEB DNAH5 DNAH6 DYNC1I1 DYNC1I2	6.22e-08	47	76	5	8812413
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	TRIO HAUS5 SHPRH CCDC85C HERC2 ZZEF1 TRRAP	4.33e-07	212	76	7	33853758
Pubmed	Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.	CACNA1D CACNA1F CACNA1G	5.57e-07	8	76	3	28330839
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1C CACNA1F CACNA1G	8.34e-07	9	76	3	16382099
Pubmed	Transport of the outer dynein arm complex to cilia requires a cytoplasmic protein Lrrc6.	DNAH5 DYNC1I1 DYNC1I2	8.34e-07	9	76	3	27353389
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	CACNA1C CACNA1D CACNA1F CACNA1G	1.47e-06	38	76	4	30786075
Pubmed	NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth.	CACNA1C CACNA1D CACNA1F	1.63e-06	11	76	3	18809727
Pubmed	Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.	CACNA1C CACNA1D CACNA1F	4.48e-06	15	76	3	20188150
Pubmed	Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.	CACNA1C CACNA1D CACNA1F	4.48e-06	15	76	3	24453333
Pubmed	Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human.	DYNC1I1 DYNC1I2	4.71e-06	2	76	2	10049579
Pubmed	Deletion of the L-type calcium channel Ca(V) 1.3 but not Ca(V) 1.2 results in a diminished sAHP in mouse CA1 pyramidal neurons.	CACNA1C CACNA1D	4.71e-06	2	76	2	20014384
Pubmed	Role of putative voltage-sensor countercharge D4 in regulating gating properties of CaV1.2 and CaV1.3 calcium channels.	CACNA1C CACNA1D	4.71e-06	2	76	2	30001160
Pubmed	Rescue and worsening of congenital heart block-associated electrocardiographic abnormalities in two transgenic mice.	CACNA1C CACNA1D	4.71e-06	2	76	2	21352396
Pubmed	Different roles attributed to Cav1 channel subtypes in spontaneous action potential firing and fine tuning of exocytosis in mouse chromaffin cells.	CACNA1C CACNA1D	4.71e-06	2	76	2	21054386
Pubmed	Molecular nature of anomalous L-type calcium channels in mouse cerebellar granule cells.	CACNA1C CACNA1D	4.71e-06	2	76	2	17409250
Pubmed	Neuronal L-type calcium channels open quickly and are inhibited slowly.	CACNA1C CACNA1D	4.71e-06	2	76	2	16267232
Pubmed	Concomitant genetic ablation of L-type Cav1.3 (α1D) and T-type Cav3.1 (α1G) Ca2+ channels disrupts heart automaticity.	CACNA1D CACNA1G	4.71e-06	2	76	2	33144668
Pubmed	The role of L-type voltage-gated calcium channels Cav1.2 and Cav1.3 in normal and pathological brain function.	CACNA1C CACNA1D	4.71e-06	2	76	2	24996399
Pubmed	Voltage-Gated Cav1 Channels in Disorders of Vision and Hearing.	CACNA1D CACNA1F	4.71e-06	2	76	2	25966695
Pubmed	An improved targeted cAMP sensor to study the regulation of adenylyl cyclase 8 by Ca2+ entry through voltage-gated channels.	CACNA1C CACNA1D	4.71e-06	2	76	2	24086669
Pubmed	Genetic, cellular, and functional evidence for Ca2+ inflow through Cav1.2 and Cav1.3 channels in murine spiral ganglion neurons.	CACNA1C CACNA1D	4.71e-06	2	76	2	24849370
Pubmed	Differential zinc permeation and blockade of L-type Ca2+ channel isoforms Cav1.2 and Cav1.3.	CACNA1C CACNA1D	4.71e-06	2	76	2	26049024
Pubmed	Divide and conquer: an L-type voltage-gated calcium channel subtype finds a role in conditioned fear.	CACNA1C CACNA1D	4.71e-06	2	76	2	17015854
Pubmed	Genetic polymorphisms of L-type calcium channel alpha1C and alpha1D subunit genes are associated with sensitivity to the antihypertensive effects of L-type dihydropyridine calcium-channel blockers.	CACNA1C CACNA1D	4.71e-06	2	76	2	19225208
Pubmed	Ca1.2 and CaV1.3 neuronal L-type calcium channels: differential targeting and signaling to pCREB.	CACNA1C CACNA1D	4.71e-06	2	76	2	16706838
Pubmed	Temperature-sensitive Cav1.2 calcium channels support intrinsic firing of pyramidal neurons and provide a target for the treatment of febrile seizures.	CACNA1C CACNA1D	4.71e-06	2	76	2	23761887
Pubmed	Non-voltage-gated L-type Ca2+ channels in human T cells: pharmacology and molecular characterization of the major alpha pore-forming and auxiliary beta-subunits.	CACNA1C CACNA1D	4.71e-06	2	76	2	14981074
Pubmed	CaV1.2 and CaV1.3 channel hyperactivation in mouse islet β cells exposed to type 1 diabetic serum.	CACNA1C CACNA1D	4.71e-06	2	76	2	25292336
Pubmed	Ca(v)1.3 channels produce persistent calcium sparklets, but Ca(v)1.2 channels are responsible for sparklets in mouse arterial smooth muscle.	CACNA1C CACNA1D	4.71e-06	2	76	2	17526649
Pubmed	Mettl3 deficiency leads to the upregulation of Cav1.2 and increases arrhythmia susceptibility in mice.	CACNA1C METTL3	4.71e-06	2	76	2	35130614
Pubmed	Ligand-activated signal transduction in the 2-cell embryo.	CACNA1C CACNA1D	4.71e-06	2	76	2	12606379
Pubmed	Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca2+ channel activators.	CACNA1C CACNA1D	4.71e-06	2	76	2	24941892
Pubmed	Cav1.2 and Cav1.3 L-type calcium channels regulate dopaminergic firing activity in the mouse ventral tegmental area.	CACNA1C CACNA1D	4.71e-06	2	76	2	24848473
Pubmed	Equal sensitivity of Cav1.2 and Cav1.3 channels to the opposing modulations of PKA and PKG in mouse chromaffin cells.	CACNA1C CACNA1D	4.71e-06	2	76	2	22826131
Pubmed	C-terminal modulator controls Ca2+-dependent gating of Ca(v)1.4 L-type Ca2+ channels.	CACNA1D CACNA1F	4.71e-06	2	76	2	16921373
Pubmed	Transcriptional regulation of L-type calcium channel subtypes Cav1.2 and Cav1.3 by nicotine and their potential role in nicotine sensitization.	CACNA1C CACNA1D	4.71e-06	2	76	2	24470632
Pubmed	Cav1.2 and Cav1.3 L-type calcium channels operate in a similar voltage range but show different coupling to Ca(2+)-dependent conductances in hippocampal neurons.	CACNA1C CACNA1D	4.71e-06	2	76	2	24760982
Pubmed	Mouse cytoplasmic dynein intermediate chains: identification of new isoforms, alternative splicing and tissue distribution of transcripts.	DYNC1I1 DYNC1I2	4.71e-06	2	76	2	20657784
Pubmed	Calcium handling precedes cardiac differentiation to initiate the first heartbeat.	CACNA1C CACNA1D CACNA1G	6.67e-06	17	76	3	27725084
Pubmed	Loss of the neurodevelopmental gene Zswim6 alters striatal morphology and motor regulation.	ZSWIM5 GPR88 ZSWIM4	9.47e-06	19	76	3	28433741
Pubmed	p53 prevents entry into mitosis with uncapped telomeres.	CDKN1A TERF1	1.41e-05	3	76	2	20226664
Pubmed	The intracellular II-III loops of Cav1.2 and Cav1.3 uncouple L-type voltage-gated Ca2+ channels from glucagon-like peptide-1 potentiation of insulin secretion in INS-1 cells via displacement from lipid rafts.	CACNA1C CACNA1D	1.41e-05	3	76	2	19351867
Pubmed	Truncation of murine CaV1.2 at Asp-1904 results in heart failure after birth.	CACNA1C CACNA1D	1.41e-05	3	76	2	21832054
Pubmed	Angiotensin II suppresses long-term depression in the lateral amygdala of mice via L-type calcium channels.	CACNA1C CACNA1D	1.41e-05	3	76	2	17289261
Pubmed	Differential effect of T-type voltage-gated Ca2+ channel disruption on renal plasma flow and glomerular filtration rate in vivo.	CACNA1D CACNA1G	1.41e-05	3	76	2	24966091
Pubmed	Functional roles of Ca(v)1.3, Ca(v)3.1 and HCN channels in automaticity of mouse atrioventricular cells: insights into the atrioventricular pacemaker mechanism.	CACNA1D CACNA1G	1.41e-05	3	76	2	21406960
Pubmed	Potent inhibition of L-type Ca2+ currents by a Rad variant associated with congestive heart failure.	CACNA1C CACNA1D	1.41e-05	3	76	2	23973784
Pubmed	Impairment of hippocampal gamma-frequency oscillations in vitro in mice overexpressing human amyloid precursor protein (APP).	CACNA1C CACNA1D	1.41e-05	3	76	2	17767505
Pubmed	MicroRNA-1976 regulates degeneration of the sinoatrial node by targeting Cav1.2 and Cav1.3 ion channels.	CACNA1C CACNA1D	1.41e-05	3	76	2	31302118
Pubmed	Distinct localization and modulation of Cav1.2 and Cav1.3 L-type Ca2+ channels in mouse sinoatrial node.	CACNA1C CACNA1D	1.41e-05	3	76	2	23045342
Pubmed	Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice.	CACNA1C CACNA1G	1.41e-05	3	76	2	22133878
Pubmed	Inhibition of G protein-gated K+ channels by tertiapin-Q rescues sinus node dysfunction and atrioventricular conduction in mouse models of primary bradycardia.	CACNA1D CACNA1G	1.41e-05	3	76	2	32555258
Pubmed	Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes.	CACNA1C CACNA1D	1.41e-05	3	76	2	2173707
Pubmed	Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons.	CACNA1C CACNA1D	1.41e-05	3	76	2	24934288
Pubmed	T-type, but not L-type, voltage-gated calcium channels are dispensable for lymphatic pacemaking and spontaneous contractions.	CACNA1C CACNA1G	1.41e-05	3	76	2	31919478
Pubmed	G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block.	CACNA1C CACNA1D	1.41e-05	3	76	2	26831068
Pubmed	METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke.	METTL3 NEDD4L	1.41e-05	3	76	2	38302612
Pubmed	DNAH6 and Its Interactions with PCD Genes in Heterotaxy and Primary Ciliary Dyskinesia.	DNAH5 DNAH6	1.41e-05	3	76	2	26918822
Pubmed	Electric field stimulation unmasks a subtle role for T-type calcium channels in regulating lymphatic contraction.	CACNA1C CACNA1G	1.41e-05	3	76	2	37739992
Pubmed	Truncation of murine CaV1.2 at Asp 1904 increases CaV1.3 expression in embryonic atrial cardiomyocytes.	CACNA1C CACNA1D	1.41e-05	3	76	2	23338940
Pubmed	Genetic dissection of horizontal cell inhibitory signaling in mice in complete darkness in vivo.	CACNA1D CACNA1F	1.41e-05	3	76	2	26024096
Pubmed	Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2.	CACNA1C CACNA1D	2.82e-05	4	76	2	17110593
Pubmed	Functional importance of L- and P/Q-type voltage-gated calcium channels in human renal vasculature.	CACNA1C CACNA1G	2.82e-05	4	76	2	21788606
Pubmed	NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation.	CDKN1A METTL3	2.82e-05	4	76	2	28247949
Pubmed	Poly-ADP ribosylation of p21 by tankyrases promotes p21 degradation and regulates cell cycle progression.	CDKN1A TERF1	2.82e-05	4	76	2	36383218
Pubmed	Interaction of SQSTM1 with the motor protein dynein--SQSTM1 is required for normal dynein function and trafficking.	DYNC1I1 DYNC1I2	4.69e-05	5	76	2	25015291
Pubmed	Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma.	DYNC1I1 DYNC1I2	4.69e-05	5	76	2	30250299
Pubmed	Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.	CACNA1C CACNA1D	4.69e-05	5	76	2	15451373
Pubmed	Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons.	CACNA1C CACNA1D	4.69e-05	5	76	2	31663850
Pubmed	Developmental expression patterns of alpha1H T-type Ca2+ channels during spermatogenesis and organogenesis in mice.	CACNA1D CACNA1G	4.69e-05	5	76	2	12060068
Pubmed	Estrogen receptor-dependent proteasomal degradation of the glucocorticoid receptor is coupled to an increase in mdm2 protein expression.	CDKN1A TRRAP	4.69e-05	5	76	2	12897156
Pubmed	Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.	CACNA1C CACNA1D	4.69e-05	5	76	2	11296258
Pubmed	K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.	USP5 KATNAL2 TRMT2A SPOCK1 OSBPL8 DMBT1 HERC2 QSOX2	5.28e-05	604	76	8	38803224
Pubmed	Voltage-gated calcium channels in developing GnRH-1 neuronal system in the mouse.	CACNA1C CACNA1D	7.03e-05	6	76	2	16029198
Pubmed	The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit.	ATP1A4 ATP4A	7.03e-05	6	76	2	3036582
Pubmed	Animal models of lysosomal disease: an overview.	DYNC1I1 DYNC1I2	7.03e-05	6	76	2	9728334
Pubmed	Functional roles of a C-terminal signaling complex of CaV1 channels and A-kinase anchoring protein 15 in brain neurons.	CACNA1C CACNA1D	7.03e-05	6	76	2	21224388
Pubmed	The HERC2 ubiquitin ligase is essential for embryonic development and regulates motor coordination.	CDKN1A HERC2	7.03e-05	6	76	2	27528230
Pubmed	Vimentin-dependent spatial translocation of an activated MAP kinase in injured nerve.	DYNC1I1 KPNA1	7.03e-05	6	76	2	15748847
Pubmed	L-type calcium channels play a critical role in maintaining lens transparency by regulating phosphorylation of aquaporin-0 and myosin light chain and expression of connexins.	CACNA1C CACNA1D	7.03e-05	6	76	2	23734214
Pubmed	Temporal profiles of the subcellular localization of Bim, a BH3-only protein, during middle cerebral artery occlusion in mice.	DYNC1I1 DYNC1I2	9.83e-05	7	76	2	12142566
Pubmed	A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins.	DYNC1I1 DYNC1I2	9.83e-05	7	76	2	11751894
Pubmed	A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system.	DYNC1I1 DYNC1I2	9.83e-05	7	76	2	11163259
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	FBH1 CELSR3 ATRX TRIO SPTBN2 OSBPL8 HERC2 SIM2 TERF1 DYNC1I1 KPNA1	1.06e-04	1285	76	11	35914814
Pubmed	Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.	CAD ZZEF1 ATP4A QSOX2	1.13e-04	113	76	4	30352685
Pubmed	Neuronal calcium sensor-1 promotes immature heart function and hypertrophy by enhancing Ca2+ signals.	CACNA1C CACNA1G	1.31e-04	8	76	2	21737792
Pubmed	Repurposing Brigatinib for the Treatment of Colorectal Cancer Based on Inhibition of ER-phagy.	USP5 OSBPL8	1.31e-04	8	76	2	31410188
Pubmed	Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33.	USP5 HERC2	1.31e-04	8	76	2	22451720
Pubmed	Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study.	DNAH5 WDFY4	1.31e-04	8	76	2	17903303
Pubmed	Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m6A Methylation.	USP5 METTL3	1.31e-04	8	76	2	33217317
Pubmed	HIV-1 uncoating is facilitated by dynein and kinesin 1.	DYNC1I1 DYNC1I2	1.31e-04	8	76	2	25231297
Pubmed	HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus.	DYNC1I1 DYNC1I2	1.31e-04	8	76	2	25818806
Pubmed	Intracellular calcium plays an essential role in cardiac development.	CACNA1C CACNA1G	1.31e-04	8	76	2	12761855
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	CACNA1C CACNA1D SHPRH MED12L HERC2 ABCC10	1.65e-04	371	76	6	15747579
Pubmed	Krox-20 is a key regulator of rhombomere-specific gene expression in the developing hindbrain.	EPHA2 FST	1.68e-04	9	76	2	9256343
Pubmed	Modulation of activin/bone morphogenetic protein signaling by follistatin is required for the morphogenesis of mouse molar teeth.	CDKN1A FST	1.68e-04	9	76	2	15305290
Pubmed	Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage.	CACNA1C CACNA1G	2.10e-04	10	76	2	24778262
Pubmed	Tel2 regulates the stability of PI3K-related protein kinases.	TERF1 TRRAP	2.10e-04	10	76	2	18160036
GeneFamily	Calcium voltage-gated channel subunits	CACNA1C CACNA1D CACNA1F CACNA1G	1.45e-06	26	59	4	253
GeneFamily	Zinc fingers SWIM-type\|Mitogen-activated protein kinase kinase kinases	ZSWIM5 ZSWIM4	3.71e-04	9	59	2	90
GeneFamily	Dyneins, cytoplasmic	DYNC1I1 DYNC1I2	7.98e-04	13	59	2	538
GeneFamily	Dyneins, axonemal	DNAH5 DNAH6	1.38e-03	17	59	2	536
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	HERC2 ZZEF1	1.55e-03	18	59	2	91
GeneFamily	PRAME family	PRAMEF26 PRAMEF6	2.76e-03	24	59	2	686
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHG4 SPTBN2 OSBPL8 FERMT3	4.57e-03	206	59	4	682
GeneFamily	WD repeat domain containing	WDR87 WDFY4 DYNC1I1 DYNC1I2	1.05e-02	262	59	4	362
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DMGDH CACNA1D KATNAL2 NEDD4L PXDNL SORCS2 SIM2	2.73e-08	182	76	7	041bc819e6cf2618bf86bce8dfe2df673f392ba3
ToppCell	Control-B_activate-7\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	OTOA ZSWIM9 SPTBN2 SORCS2 MED12L ZNF683	4.62e-08	115	76	6	cc2f8fb0cbb72b241b65a69195aac0507bddf2e2
ToppCell	TCGA-Colorectal-Primary_Tumor\|TCGA-Colorectal / Sample_Type by Project: Shred V9	CAD SPTBN2 HAUS5 SIM2 ZSWIM4 QSOX2	1.17e-06	199	76	6	c7d6a8398f2419b726a0461585d1ee0561654e3b
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma\|TCGA-Colorectal / Sample_Type by Project: Shred V9	CAD SPTBN2 HAUS5 SIM2 ZSWIM4 QSOX2	1.17e-06	199	76	6	85b3b1ad01368dae4adbc9da7efc148e49992f69
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	OTOA CACNA1C CACNA1D PXDNL CPZ	2.41e-06	125	76	5	b162a5bfbb8ac5e65e13578fef9de442a9e4fd8b
ToppCell	Control-B_activate-7\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	OTOA SPTBN2 SORCS2 MED12L ZNF683	2.92e-06	130	76	5	d3343c19d61928f18e7d707eda5dec6e0fd2a9a2
ToppCell	wk_15-18-Epithelial-Airway_epithelial_progenitor-epi-prox-progenitor_intermediate_\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CACNA1F NEDD4L SPTBN2 MED12L SIM2	9.35e-06	165	76	5	f6887c64af0f26e33316bc5587487e24d76ece2a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DMGDH KATNAL2 PXDNL SORCS2 SIM2	1.14e-05	172	76	5	1565f38266891c3acf49778838de134c5dee5460
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA CACNA1F NEB ATP1A4 DNAH5	1.58e-05	184	76	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	Control-Myeloid-cDC1\|Myeloid / Disease state, Lineage and Cell class	TRAV5 PNMA1 MED12L IRAK2 WDFY4	1.58e-05	184	76	5	c6affa0b12510363258f65e46bf2d47bf4a8e75f
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA CACNA1F NEB ATP1A4 DNAH5	1.58e-05	184	76	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA CACNA1F NEB ATP1A4 DNAH5	1.58e-05	184	76	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DMGDH CACNA1D KATNAL2 PXDNL SIM2	1.67e-05	186	76	5	1850583d23903d08226aeb0edb3e07b0994330e4
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DMGDH CACNA1D KATNAL2 PXDNL SIM2	1.67e-05	186	76	5	4dafc215c42e7949f932a3627359c107943b5d6b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1D KATNAL2 PXDNL SIM2 RAP2C	1.89e-05	191	76	5	963f4f2e852bbb4faf070aafb0d368297abacd3b
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1C CACNA1D OSBPL8 DYNC1I1 DYNC1I2	2.25e-05	198	76	5	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	Sepsis-Bac-SEP-Myeloid-tDC\|Bac-SEP / Disease, condition lineage and cell class	CACNA1F CAD TRMT2A TRIO HAUS5	2.30e-05	199	76	5	a2be40d367338d32348a6906c8475aa3b544a0f7
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr-Excitatory_Neuron.Slc17a7.Nptxr-Deptor_(Deep_layer_pyramidal_cells--Layer_5a)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	OTOA GPR27 NEB FST	3.53e-05	108	76	4	514dfc3f7ac303311ae599f981f3f3c7eb6801b8
Drug	Cinnarizine	CACNA1C CACNA1D CACNA1F CACNA1G	1.21e-08	9	73	4	DB00568
Drug	Mibefradil	CACNA1C CACNA1D CACNA1F CACNA1G	3.15e-08	11	73	4	DB01388
Drug	Verapamil	CACNA1C CACNA1D CACNA1F CACNA1G	1.72e-07	16	73	4	DB00661
Drug	KW-3049	CACNA1C CACNA1D CACNA1F CACNA1G FST	5.58e-07	50	73	5	CID000002324
Drug	Nimodipine	CACNA1C CACNA1D CACNA1F	2.62e-06	9	73	3	DB00393
Drug	(cis-) Nanophine [5072-45-7]; Up 200; 26.8uM; MCF7; HT_HG-U133A	CACNA1C NEDD4L TRIO HAUS5 DMBT1 SIM2 DYNC1I1	3.17e-06	196	73	7	3889_UP
Drug	CNS 1145	CACNA1C CACNA1D CACNA1F CACNA1G	3.71e-06	33	73	4	CID000190902
Drug	IHC-64	CACNA1C CACNA1D CACNA1F CACNA1G	3.71e-06	33	73	4	CID000162753
Drug	nicardipine	CACNA1C CACNA1D CACNA1F PNMA1 CACNA1G CHRNE	7.21e-06	145	73	6	CID000004473
Drug	isotetrandrine	CDKN1A CACNA1C CACNA1D CACNA1F CACNA1G	1.51e-05	97	73	5	CID000005422
Drug	prochloraz	TMEM150B CACNA1C CACNA1D TRMT2A SPTBN2 CACNA1G DYNC1I1	2.43e-05	268	73	7	ctd:C045362
Drug	Podophyllotoxin [518-28-5]; Up 200; 9.6uM; PC3; HT_HG-U133A	CDKN1A TRIO HAUS5 DMBT1 NEB FST	3.05e-05	187	73	6	5841_UP
Drug	Cinildipine	CACNA1C CACNA1D CACNA1F CACNA1G	3.15e-05	56	73	4	CID000002752
Drug	guanethidine	CDKN1A DMGDH GALE FST CHRNE	3.16e-05	113	73	5	CID000003518
Drug	AC1NBU2S	CDKN1A CACNA1C CACNA1D CACNA1F CACNA1G	3.74e-05	117	73	5	CID004473765
Drug	Sulfinpyrazone [57-96-5]; Down 200; 9.8uM; MCF7; HT_HG-U133A	USP5 NEDD4L CELSR3 HAUS5 CCDC85C ABCC10	4.09e-05	197	73	6	6230_DN
Drug	nilvadipine	CACNA1C CACNA1D CACNA1F CACNA1G	4.14e-05	60	73	4	CID000004494
Drug	Bucladesine sodium salt [16980-89-5]; Up 200; 7.8uM; PC3; HT_HG-U133A	USP5 CCDC85C CACNA1G DMBT1 NEB ZZEF1	4.21e-05	198	73	6	5886_UP
Drug	IAA-94	CACNA1C CACNA1D CACNA1F CACNA1G	4.42e-05	61	73	4	CID000003667
Drug	Tolfenamic acid [13710-19-5]; Up 200; 15.2uM; MCF7; HT_HG-U133A	NEDD4L SPTBN2 CCDC85C DMBT1 ZZEF1 TTC38	4.45e-05	200	73	6	5454_UP
Drug	lercanidipine	CACNA1C CACNA1D CACNA1F CACNA1G	5.02e-05	63	73	4	CID000065866
Drug	Linuron	CDKN1A CACNA1C CACNA1D SPTBN2 CACNA1G	5.74e-05	128	73	5	ctd:D008044
Drug	enzacamene	CACNA1C CACNA1D CACNA1F SPTBN2 CACNA1G	5.96e-05	129	73	5	ctd:C038939
Drug	AC1L1TJF	CACNA1C CACNA1D CACNA1F CACNA1G	6.03e-05	66	73	4	CID000003377
Drug	NSC-686960	CACNA1C CACNA1D	6.06e-05	4	73	2	CID000192816
Drug	sparfosic acid	CDKN1A CAD	6.06e-05	4	73	2	ctd:C013195
Drug	gallopamil	CACNA1C CACNA1D CACNA1F CACNA1G	6.40e-05	67	73	4	CID000001234
Drug	AC1L2AC7	CACNA1C CACNA1D CACNA1F CACNA1G	7.18e-05	69	73	4	CID000068733
Drug	Barium	CACNA1C CACNA1D CACNA1F CACNA1G	8.48e-05	72	73	4	ctd:D001464
Drug	octylmethoxycinnamate	CACNA1C CACNA1D CACNA1F SPTBN2 CACNA1G	8.49e-05	139	73	5	ctd:C118580
Drug	CAS 298-57-7	CACNA1C CACNA1D CACNA1F CACNA1G	8.95e-05	73	73	4	CID000002761
Drug	ethosuximide	CACNA1C CACNA1D CACNA1F CACNA1G	9.44e-05	74	73	4	CID000003291
Drug	Nilvadipine	CACNA1C CACNA1D	1.01e-04	5	73	2	DB06712
Drug	Nisoldipine	CACNA1C CACNA1D	1.01e-04	5	73	2	DB00401
Drug	B 874-67	CACNA1C CACNA1D	1.01e-04	5	73	2	CID000195466
Drug	methyl beta-aminocrotonate	CACNA1C CACNA1D	1.01e-04	5	73	2	CID000084253
Drug	nemadipine-A	CACNA1C CACNA1D	1.01e-04	5	73	2	CID002856102
Drug	nimodipine	CACNA1C CACNA1D CACNA1F PNMA1 CACNA1G	1.04e-04	145	73	5	CID000004497
Drug	nisoldipine	CACNA1C CACNA1D CACNA1F CACNA1G	1.16e-04	78	73	4	CID000004499
Drug	N-cyclopentyl-N-cyclobutylformamide	CACNA1C CACNA1D CACNA1F CACNA1G	1.22e-04	79	73	4	CID005287890
Drug	procaine	CACNA1C CACNA1D CACNA1F CACNA1G CHRNE	1.33e-04	153	73	5	CID000004914
Drug	butylparaben	CACNA1C CACNA1D CACNA1F SPTBN2 CACNA1G	1.51e-04	157	73	5	ctd:C038091
Drug	CPU-23	CACNA1C CACNA1D	1.51e-04	6	73	2	CID003036051
Drug	thiacloprid	MED12L FST CHRNE	1.76e-04	34	73	3	CID000115224
Drug	Amlodipine	CACNA1C CACNA1D	2.11e-04	7	73	2	DB00381
Drug	Isradipine	CACNA1C CACNA1D	2.11e-04	7	73	2	DB00270
Disease	Timothy syndrome (implicated_via_orthology)	CACNA1C CACNA1D CACNA1F	5.80e-08	4	73	3	DOID:0060173 (implicated_via_orthology)
Disease	Spinocerebellar Ataxia Type 4	PLEKHG4 SPTBN2 SCYL1 CACNA1G	1.70e-06	35	73	4	C0752122
Disease	Antihypertensive use measurement	CACNA1C CACNA1D NEDD4L PXDNL PDP2 ABCC10	5.10e-05	265	73	6	EFO_0009927
Disease	response to bevacizumab, Proteinuria	TRIO DNAH5	6.01e-05	5	73	2	EFO_0005943, HP_0000093
Disease	Spinocerebellar Ataxia Type 2	SPTBN2 SCYL1 CACNA1G	8.23e-05	34	73	3	C0752121
Disease	Spinocerebellar Ataxia Type 1	SPTBN2 SCYL1 CACNA1G	8.23e-05	34	73	3	C0752120
Disease	Spinocerebellar Ataxia Type 5	SPTBN2 SCYL1 CACNA1G	8.23e-05	34	73	3	C0752123
Disease	Spinocerebellar Ataxia Type 7	SPTBN2 SCYL1 CACNA1G	8.23e-05	34	73	3	C0752125
Disease	Spinocerebellar Ataxia Type 6 (disorder)	SPTBN2 SCYL1 CACNA1G	8.23e-05	34	73	3	C0752124
Disease	Ataxia, Spinocerebellar	SPTBN2 SCYL1 CACNA1G	8.23e-05	34	73	3	C0087012
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	CACNA1C CACNA1D CACNA1F	9.78e-05	36	73	3	DOID:11723 (implicated_via_orthology)
Disease	familial hemiplegic migraine (implicated_via_orthology)	ATP1A4 ATP4A	1.26e-04	7	73	2	DOID:0060178 (implicated_via_orthology)
Disease	chemotherapy-induced alopecia, methylcobalamin deficiency type cblE	TRIO DNAH5	1.67e-04	8	73	2	EFO_0005400, MONDO_0009354
Disease	Anemia, Sickle Cell	CACNA1C CAD	2.68e-04	10	73	2	C0002895
Disease	nervous system disease (implicated_via_orthology)	ATP1A4 ATP4A	3.92e-04	12	73	2	DOID:863 (implicated_via_orthology)
Disease	Intellectual Disability	GALE TRIO MED12L CACNA1G TRRAP DYNC1I2	8.45e-04	447	73	6	C3714756
Disease	selenium measurement, response to dietary selenium supplementation	TRIO DNAH5	1.11e-03	20	73	2	EFO_0006331, EFO_0600021
Disease	palmitoylcarnitine measurement	SPOCK1 ATP1A4	1.23e-03	21	73	2	EFO_0021044
Disease	cerebellar cortex volume measurement	PXDNL SIM2	1.23e-03	21	73	2	EFO_0010291
Disease	Agents acting on the renin-angiotensin system use measurement	CACNA1C CACNA1D RASSF10 ABCC10 FERMT3	1.46e-03	335	73	5	EFO_0009931
Disease	energy expenditure	RASSF10 DYNC1I1	2.04e-03	27	73	2	EFO_0005109

Protein segments in the cluster

Peptide	Gene	Start	Entry
FLWLQLDCMSRGEDV	TRAV5	11	A0A0B4J249
WRLLAQEEAAMDAGA	USHBP1	386	Q8N6Y0
ALMAGCIQEARERWN	CDKN1A	36	P38936
DWVRMGNALDNICFW	CHRNE	446	Q04844
QACADMWVDQARGLA	RASSF10	461	A6NK89
VMSSEGRALAQEWGC	RAP2C	126	Q9Y3L5
WASAIRVAALDCMEE	QSOX2	111	Q6ZRP7
GCGLDRLQWENVSAM	OARD1	121	Q9Y530
AEANACWALEDLRCM	OTOA	841	Q7RTW8
LFRCATGEAWQEIML	CACNA1F	1376	O60840
MERLLAQLCGSSAAW	ABCC10	1	Q5T3U5
VNGCAADLSVCALWM	GPR88	71	Q9GZN0
MRGLRCDGNADDIWT	MED12L	1206	Q86YW9
WVLDDLCRNMDALSE	IRAK2	11	O43187
AFTRDGLCGLWNEMV	HERC2	26	O95714
REMCNVVWRKLGDAA	CCDC85C	386	A6NKD9
ALFACVDGMGRLDLW	DYNC1I1	546	O14576
ACVDGMGRLDLWNLN	DYNC1I2	541	Q13409
AMLVCAAWALALAAA	GPR27	141	Q9NS67
VLAASNLPWELDCAM	KATNAL2	396	Q8IYT4
FMEDRSAQAGNCWLR	FST	21	P19883
MELAQEARELGCWAV	HAUS5	1	O94927
WVTGRAMELGRECLN	METTL3	431	Q86U44
SDGRCWMDALELALK	OSBPL8	251	Q9BZF1
DCRAILGVQEDNGMW	PDP2	286	Q9P2J9
RLDSNALVCDCDLMW	PXDNL	176	A1KZ92
EELGWTAALGLDRMC	GALE	316	Q14376
TAALGLDRMCEDLWR	GALE	321	Q14376
MDEQCRWCAEGGNLI	ATRX	216	P46100
WDIDLDNCVARMALS	DNAH6	1416	Q9C0G6
EASRLWDNMRKLGEC	FBH1	601	Q8NFZ0
REVCQPAFDAIDMAW	CPZ	126	Q66K79
LLFRCATGEAWQDIM	CACNA1C	1456	Q13936
GDNWNGIMKDTLRDC	CACNA1G	1801	O43497
MELQAARACFALLWG	EPHA2	1	P29317
MAARQIWARTGAALC	C1orf53	1	Q5VUE5
EKAFRAWGLEMNCDT	DMGDH	721	Q9UI17
FCVLNADARAAWMPA	CELSR3	2771	Q9NYQ7
DANVVCRQLGCGWAM	DMBT1	1026	Q9UGM3
LEDWCRGMDVNSQRA	PNMA1	6	Q8ND90
VWSEAMARGCFLNAK	PRAMEF26	21	H0Y7S4
QLAGGLQCLMWVAAA	ATP4A	106	P20648
RCATGEAWQEIMLAC	CACNA1D	1401	Q01668
RANKGWALDNMVLCN	DNAH5	4501	Q8TE73
DWAQLDAGSMVLDVC	TRMT2A	426	Q8IZ69
SQVLNMGAALAAWIC	TMEM150B	56	A6NC51
NVCMAAVFVDRAGEW	SCYL1	141	Q96KG9
LAQDLCWELLASGMA	PLEKHG4	181	Q58EX7
WALGNIAGDSTMCRD	KPNA1	191	P52294
SWELSNLQGDRCIMG	SORCS2	656	Q96PQ0
WGQNEAADAMSRLAR	POLR3A	671	O14802
MDKLECGQLGNWRAS	SIM2	396	Q14190
AAEMAQRLSGINRWC	SHPRH	831	Q149N8
WCIEAAARIREGMAA	ACADVL	606	P49748
WFMLARIAGLCNRAD	ATP1A4	426	Q13733
VWLSAAMGFGNCVEL	CLEC18B	406	Q6UXF7
WSEAMARGCFLNAKR	PRAMEF6	116	Q5VXH4
MTDKCRQLWDELGAL	ZSWIM5	406	Q9P217
CLRDLVAMQWADAAG	ZSWIM9	426	Q86XI8
LVFGRDAGMAEAWLC	SPTBN2	2016	O15020
MTFENLAAWGRCLCA	WDFY4	2926	Q6ZS81
MPAIAVLAAAAAAWC	SPOCK1	1	Q08629
DEQQYARWMAGCRLA	FERMT3	441	Q86UX7
EAVAAGWMLDFLCLS	TERF1	71	P54274
EALWENMAVIDCFAS	CAD	1671	P27708
MAAASPLRDCQAWKD	TTC38	1	Q5R3I4
VCLDSRVGLDWACSM	ZZEF1	2191	O43149
APCWEEAMAAAFQLA	TMEM204	131	Q9BSN7
AGDGSSWRDDLCRLM	WDR87	1236	Q6ZQQ6
AANSLDNLCRMDPAW	TRRAP	3841	Q9Y4A5
KCDMRENLWLNLTDG	USP5	201	P45974
ACLAQWHQGALDLMA	ZNF683	466	Q8IZ20
MADQGRLLDCVVRWG	TRIO	2871	O75962
MTDKCRQLWDELGAL	ZSWIM4	326	Q9H7M6
RALCSLAIEGLWSMN	NLRP13	481	Q86W25
GWDEMKAGCDVRLDA	NEB	3976	P20929
LMCGLGDVDVNDWRQ	NEDD4L	851	Q96PU5