Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	NELF complex	NELFE NELFCD	2.03e-05	4	39	2	GO:0032021
Domain	OTU	OTUD4 OTUD5	3.27e-04	13	39	2	PF02338
Domain	OTU	OTUD4 OTUD5	4.39e-04	15	39	2	PS50802
Domain	OTU_dom	OTUD4 OTUD5	4.39e-04	15	39	2	IPR003323
Domain	ABC_transporter_CS	ABCF3 ABCC10	3.47e-03	42	39	2	IPR017871
Domain	ABC_TRANSPORTER_2	ABCF3 ABCC10	4.51e-03	48	39	2	PS50893
Domain	ABC_tran	ABCF3 ABCC10	4.51e-03	48	39	2	PF00005
Domain	ABC_TRANSPORTER_1	ABCF3 ABCC10	4.70e-03	49	39	2	PS00211
Domain	ABC_transporter-like	ABCF3 ABCC10	4.89e-03	50	39	2	IPR003439
Domain	SAM_1	SASH1 SCMH1	8.87e-03	68	39	2	PF00536
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	NELFE XRN1 RALGAPA1 FMN2 ACACA SASH1 MAP7D3 NCKAP1 NELFCD SEC24B	2.72e-08	861	39	10	36931259
Pubmed	Proximity labeling reveals dynamic changes in the SQSTM1 protein network.	XRN1 OTUD4 TNRC6B PLAA MAP7D3 MEIOC SEC24B	6.52e-08	322	39	7	39098523
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	NELFE XRN1 OTUD4 TNRC6B ABCF3 ACACA TBRG1 MAP7D3	1.18e-06	724	39	8	36232890
Pubmed	The XRN1-regulated RNA helicase activity of YTHDC2 ensures mouse fertility independently of m6A recognition.	XRN1 MEIOC	3.67e-06	3	39	2	35305312
Pubmed	Regulation of m6A Transcripts by the 3'→5' RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline.	XRN1 MEIOC	3.67e-06	3	39	2	29033321
Pubmed	Negative elongation factor NELF represses human immunodeficiency virus transcription by pausing the RNA polymerase II complex.	NELFE NELFCD	7.34e-06	4	39	2	17442680
Pubmed	Architecture and RNA binding of the human negative elongation factor.	NELFE NELFCD	7.34e-06	4	39	2	27282391
Pubmed	Translational Initiation at a Non-AUG Start Codon for Human and Mouse Negative Elongation Factor-B.	NELFE NELFCD	7.34e-06	4	39	2	26010750
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	XRN1 TNRC6B MAP7D3 MEIOC SEC24B	1.11e-05	263	39	5	34702444
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	XRN1 TNRC6B MEIOC PRPF40B MAML3 NUP35	1.13e-05	457	39	6	32344865
Pubmed	Cellular dynamics of the negative transcription elongation factor NELF.	NELFE NELFCD	1.22e-05	5	39	2	19245807
Pubmed	Distinct patterns of RNA polymerase II and transcriptional elongation characterize mammalian genome activation.	NELFE NELFCD	1.22e-05	5	39	2	36577375
Pubmed	NELF interacts with CBC and participates in 3' end processing of replication-dependent histone mRNAs.	NELFE NELFCD	2.56e-05	7	39	2	17499042
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	NELFE XRN1 TNRC6B ACACA MAP7D3 SEC24B	3.16e-05	549	39	6	38280479
Pubmed	Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex.	NELFE NELFCD	3.42e-05	8	39	2	12612062
Pubmed	NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation.	NELFE NELFCD	3.42e-05	8	39	2	10199401
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	XRN1 TNRC6B ACACA MAP7D3 MEIOC NCKAP1 SEC24B	4.04e-05	853	39	7	28718761
Pubmed	HIV-1 chromatin, transcription, and the regulatory protein Tat.	NELFE NELFCD	4.39e-05	9	39	2	24158816
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	XRN1 OTUD4 ACACA SEC24B	5.17e-05	182	39	4	32239614
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	XRN1 TNRC6B MAP7D3 SEC24B	5.40e-05	184	39	4	32908313
Pubmed	BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.	XRN1 ABCF3 MAP7D3 NCKAP1	1.00e-04	216	39	4	31519766
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	XRN1 RALGAPA1 TNRC6B MAP7D3 NCKAP1 SEC24B	1.28e-04	708	39	6	39231216
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	NELFE TNRC6B ABCF3 ACACA SEC24B	1.33e-04	444	39	5	34795231
Pubmed	OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.	OTUD4 OTUD5	2.07e-04	19	39	2	23827681
Pubmed	The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention.	NELFE NELFCD	2.07e-04	19	39	2	16838299
Pubmed	DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation.	NELFE NELFCD	2.30e-04	20	39	2	11112772
Pubmed	Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.	XRN1 TNRC6B MAP7D3	2.39e-04	107	39	3	30995489
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	XRN1 TNRC6B HK2 PLAA ACACA NCKAP1 PDK2	2.44e-04	1139	39	7	36417873
Pubmed	Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.	ABCF3 ABCC10	2.79e-04	22	39	2	8894702
Pubmed	Defining the membrane proteome of NK cells.	XRN1 HK2 ABCF3 MAP7D3 NELFCD ALG1 GRK6	2.84e-04	1168	39	7	19946888
Pubmed	Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus.	ABCF3 ABCC10	3.05e-04	23	39	2	10708515
Pubmed	GGPP depletion initiates metaflammation through disequilibrating CYB5R3-dependent eicosanoid metabolism.	HK2 PDK2	3.62e-04	25	39	2	32913122
Pubmed	Hypoxic regulation of hand1 controls the fetal-neonatal switch in cardiac metabolism.	HK2 ACACA	4.23e-04	27	39	2	24086110
Pubmed	A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.	AADAT SASH1	5.58e-04	31	39	2	23408906
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	NELFE XRN1 TNRC6B ACACA MAP7D3 SEC24B	5.65e-04	934	39	6	33916271
Pubmed	The RNA polymerase II elongation complex.	NELFE NELFCD	6.33e-04	33	39	2	12676794
Pubmed	MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.	ALG1 GRK6 NUP35	6.41e-04	150	39	3	22678362
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	XRN1 HK2 ABCF3 PLAA ACACA NCKAP1 SEC24B	6.85e-04	1353	39	7	29467282
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	FMN2 RIMBP2 NCKAP1 ABCC10	7.80e-04	371	39	4	15747579
Pubmed	A RECQ5-RNA polymerase II association identified by targeted proteomic analysis of human chromatin.	NELFE NELFCD	7.96e-04	37	39	2	18562274
Pubmed	A long non-coding RNA specifically expressed in early embryos programs the metabolic balance in adult mice.	HK2 ACACA	8.84e-04	39	39	2	33059001
Pubmed	Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.	XRN1 TNRC6B MAP7D3	9.06e-04	169	39	3	31462741
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	OTUD4 TNRC6B RIMBP2 NCKAP1	1.10e-03	407	39	4	12693553
Interaction	MAML3 interactions	SCMH1 MAML3 NUP35	7.47e-06	20	39	3	int:MAML3
Interaction	PATL1 interactions	XRN1 OTUD4 TNRC6B ACACA SEC24B	2.23e-05	177	39	5	int:PATL1
GeneFamily	OTU domain containing	OTUD4 OTUD5	1.41e-04	17	19	2	669
GeneFamily	Ataxins\|Trinucleotide repeat containing	TNRC6B MAML3	3.09e-04	25	19	2	775
GeneFamily	Sterile alpha motif domain containing	SASH1 SCMH1	3.80e-03	88	19	2	760
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	RIMBP2 TMEM132D	1.52e-02	181	19	2	694
GeneFamily	EF-hand domain containing	PLCZ1 RYR3	2.18e-02	219	19	2	863
ToppCell	droplet-Lung-3m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2-17-52\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLAA NELFCD D2HGDH SEC24B	1.33e-05	166	39	4	de319c960b0cd90b294f677d1ea1b013a2ce2d53
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Classical_Monocyte-Mono_c1-CD14-CCL3\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FMN2 ZSCAN25 HK2 PDK2	1.64e-05	175	39	4	5a29323d4a848ea544cdd78a0a4b73f9c122dc5e
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	TNRC6B ACACA SCMH1 MAML3	2.71e-05	199	39	4	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
Disease	Epileptic encephalopathy	PLAA RYR3	6.16e-04	30	36	2	C0543888
Disease	serum metabolite measurement	RALGAPA1 OTUD4 ZSCAN25 NELFCD D2HGDH GRK6	9.09e-04	945	36	6	EFO_0005653
Disease	pyruvate measurement	OTUD4 SASH1 TMEM132D	4.24e-03	268	36	3	EFO_0010117
Disease	Neurodevelopmental Disorders	TNRC6B NCKAP1	5.77e-03	93	36	2	C1535926
Disease	cognitive function measurement	RIMBP2 PLAA PRPF40B SCMH1 MAML3 RYR3	7.25e-03	1434	36	6	EFO_0008354
Disease	diet measurement	TNRC6B PRPF40B SCMH1 MAML3 GRK6	8.49e-03	1049	36	5	EFO_0008111

Protein segments in the cluster

Peptide	Gene	Start	Entry
LAGGLPNPNMFPFKT	AADAT	36	Q8N5Z0
MLFQPSLAGSTQPGL	ACTL7B	301	Q9Y614
QMLFSNFPDPAGKLN	ALG1	421	Q9BT22
LAGLGFTPKMQQQPT	ABCF3	311	Q9NUQ8
LLLKNGIAFMGPPSQ	ACACA	221	Q13085
QMLFSNFPDPAGKLN	ALG1L	116	Q6GMV1
LSGKNMFPQPSFGPN	OTUD4	831	Q01804
AKKPAGGVSLFFMPN	DZIP1L	686	Q8IYY4
MGLFSPQLLLFSPGN	ABCC10	931	Q5T3U5
PAFLDLFMQSLFKPG	NELFCD	331	Q8IXH7
MTPTLLRGAFSPFGN	NELFE	271	P18615
GPGFLGSQPQAAIMK	MAML3	726	Q96JK9
MKGVSLPLGFTFSFP	HK2	591	P52789
PGLLGPKALFVFMAL	NCKAP1	361	Q9Y2A7
FSPSPLSMKQFLDFG	PDK2	26	Q15119
GPGPASLFLAMFQSR	NPAS4	206	Q8IUM7
NGTGSPTKFKMPFNN	MAP7D3	766	Q8IWC1
LNFKRLGAGMLEPPF	GRK6	451	P43250
PLPSGLFGLGMNQDK	FMN2	1266	Q9NZ56
GPALQAAFKLMSPTG	SEC24B	791	O95487
LGYSKPPGALQLMQQ	D2HGDH	486	Q8N465
GLPSFKPGFAEQSLM	OTUD5	351	Q96G74
PKPGVNAQFLPGFLM	NUP35	26	Q8NFH5
FSGLMPTFGFQRPIK	MEIOC	731	A2RUB1
SKPFPQFMNGLATSL	RIMBP2	86	O15034
MLPSNPFGFTNKFSL	TMEM132D	111	Q14C87
QTPGLPMDLQNGKFL	PLCZ1	436	Q86YW0
GMLQPPLGFRLNASS	SCMH1	121	Q96GD3
SPQFFSLGLPGATML	RALGAPA1	1196	Q6GYQ0
GNFDPKPINTMNFSL	RYR3	2596	Q15413
MTAKDLGLPGFFPSQ	TEX37	76	Q96LM6
LGFKATLPPFMHNTG	SSX7	61	Q7RTT5
SQGLGPFKDMALAFP	ZSCAN25	226	Q6NSZ9
KGQMLGLGNPSFSDP	PLAA	456	Q9Y263
ALQQLGSLGMNFPLP	XRN1	1501	Q8IZH2
NQLGNYPTLPLMKSG	SASH1	761	O94885
NMLGQPGSTPLDLFK	PRPF40B	531	Q6NWY9
GNFFMLLPTSGIPSS	ZNF621	396	Q6ZSS3
AGLPAFLAMPFNSLV	TMEM187	46	Q14656
KLMPNLLPAGADFFG	TBRG1	281	Q3YBR2
MLKQFPNSGLSPGLF	TNRC6B	1241	Q9UPQ9