Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	complement component C3b binding	CR1 ITGB2	2.06e-04	12	36	2	GO:0001851
GeneOntologyBiologicalProcess	negative regulation of complement activation, classical pathway	CD46 CR1 SVEP1	2.96e-07	8	37	3	GO:0045959
GeneOntologyBiologicalProcess	regulation of complement activation, classical pathway	CD46 CR1 SVEP1	6.32e-07	10	37	3	GO:0030450
GeneOntologyBiologicalProcess	negative regulation of humoral immune response mediated by circulating immunoglobulin	CD46 CR1 SVEP1	1.16e-06	12	37	3	GO:0002924
GeneOntologyBiologicalProcess	negative regulation of complement activation	CD46 CR1 SVEP1	1.91e-06	14	37	3	GO:0045916
GeneOntologyBiologicalProcess	negative regulation of immunoglobulin mediated immune response	CD46 CR1 SVEP1	2.93e-06	16	37	3	GO:0002890
GeneOntologyBiologicalProcess	negative regulation of B cell mediated immunity	CD46 CR1 SVEP1	2.93e-06	16	37	3	GO:0002713
GeneOntologyBiologicalProcess	negative regulation of humoral immune response	CD46 CR1 SVEP1	5.05e-06	19	37	3	GO:0002921
GeneOntologyBiologicalProcess	regulation of humoral immune response mediated by circulating immunoglobulin	CD46 CR1 SVEP1	7.99e-06	22	37	3	GO:0002923
GeneOntologyBiologicalProcess	regulation of complement activation	CD46 CR1 SVEP1	1.51e-05	27	37	3	GO:0030449
GeneOntologyBiologicalProcess	complement activation, classical pathway	CD46 CR1 SVEP1	6.69e-05	44	37	3	GO:0006958
GeneOntologyBiologicalProcess	cerebral cortex GABAergic interneuron development	RAC1 RAC3	8.71e-05	8	37	2	GO:0021894
GeneOntologyBiologicalProcess	regulation of humoral immune response	CD46 CR1 SVEP1	1.69e-04	60	37	3	GO:0002920
GeneOntologyBiologicalProcess	cerebral cortex GABAergic interneuron differentiation	RAC1 RAC3	1.70e-04	11	37	2	GO:0021892
GeneOntologyBiologicalProcess	regulation of cell shape	ITGB2 RAC1 RAC3 GAS2	1.84e-04	159	37	4	GO:0008360
GeneOntologyBiologicalProcess	humoral immune response mediated by circulating immunoglobulin	CD46 CR1 SVEP1	1.87e-04	62	37	3	GO:0002455
GeneOntologyBiologicalProcess	negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	CD46 CR1 SVEP1	2.25e-04	66	37	3	GO:0002823
GeneOntologyBiologicalProcess	phagocytosis, engulfment	ITGB2 RAC1 RAC3	2.57e-04	69	37	3	GO:0006911
GeneOntologyBiologicalProcess	complement activation	CD46 CR1 SVEP1	2.68e-04	70	37	3	GO:0006956
GeneOntologyBiologicalProcess	negative regulation of adaptive immune response	CD46 CR1 SVEP1	2.79e-04	71	37	3	GO:0002820
GeneOntologyBiologicalProcess	positive regulation of platelet activation	JAK2 SVEP1	2.81e-04	14	37	2	GO:0010572
GeneOntologyBiologicalProcess	engulfment of apoptotic cell	RAC1 RAC3	3.24e-04	15	37	2	GO:0043652
GeneOntologyBiologicalProcess	plasma membrane invagination	ITGB2 RAC1 RAC3	3.68e-04	78	37	3	GO:0099024
GeneOntologyBiologicalProcess	regulation of immunoglobulin mediated immune response	CD46 CR1 SVEP1	3.83e-04	79	37	3	GO:0002889
GeneOntologyBiologicalProcess	regulation of B cell mediated immunity	CD46 CR1 SVEP1	3.83e-04	79	37	3	GO:0002712
GeneOntologyBiologicalProcess	negative regulation of lymphocyte mediated immunity	CD46 CR1 SVEP1	4.42e-04	83	37	3	GO:0002707
GeneOntologyBiologicalProcess	regulation of neuron maturation	RAC1 RAC3	4.70e-04	18	37	2	GO:0014041
GeneOntologyBiologicalProcess	membrane invagination	ITGB2 RAC1 RAC3	5.08e-04	87	37	3	GO:0010324
GeneOntologyBiologicalProcess	positive regulation of cell adhesion	JAK2 CD46 CR1 ITGB2 RAC1 RAC3	5.28e-04	579	37	6	GO:0045785
GeneOntologyBiologicalProcess	negative regulation of leukocyte mediated immunity	CD46 CR1 SVEP1	6.77e-04	96	37	3	GO:0002704
GeneOntologyBiologicalProcess	regulation of nitric oxide biosynthetic process	JAK2 ITGB2 RAC1	6.98e-04	97	37	3	GO:0045428
GeneOntologyBiologicalProcess	regulation of nitric oxide metabolic process	JAK2 ITGB2 RAC1	7.62e-04	100	37	3	GO:0080164
GeneOntologyBiologicalProcess	cell-substrate adhesion	JAK2 ITGB2 SVEP1 RAC1 RAC3	7.82e-04	410	37	5	GO:0031589
GeneOntologyBiologicalProcess	regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	JAK2 CD46 CR1 SVEP1	8.07e-04	235	37	4	GO:0002822
GeneOntologyBiologicalProcess	GABAergic neuron differentiation	RAC1 RAC3	8.43e-04	24	37	2	GO:0097154
GeneOntologyBiologicalProcess	regulation of adaptive immune response	JAK2 CD46 CR1 SVEP1	1.05e-03	252	37	4	GO:0002819
GeneOntologyBiologicalProcess	nitric oxide biosynthetic process	JAK2 ITGB2 RAC1	1.06e-03	112	37	3	GO:0006809
GeneOntologyBiologicalProcess	cerebral cortex neuron differentiation	RAC1 RAC3	1.23e-03	29	37	2	GO:0021895
GeneOntologyBiologicalProcess	nitric oxide metabolic process	JAK2 ITGB2 RAC1	1.32e-03	121	37	3	GO:0046209
GeneOntologyBiologicalProcess	reactive nitrogen species metabolic process	JAK2 ITGB2 RAC1	1.39e-03	123	37	3	GO:2001057
GeneOntologyBiologicalProcess	postsynaptic actin cytoskeleton organization	RAC1 RAC3	1.41e-03	31	37	2	GO:0098974
GeneOntologyBiologicalProcess	positive regulation of regulatory T cell differentiation	CD46 CR1	1.41e-03	31	37	2	GO:0045591
GeneOntologyBiologicalProcess	neutrophil migration	ITGB2 RAC1 RAC3	1.63e-03	130	37	3	GO:1990266
GeneOntologyBiologicalProcess	T cell proliferation	JAK2 CD46 CR1 ITGB2	1.71e-03	288	37	4	GO:0042098
GeneOntologyBiologicalProcess	postsynaptic cytoskeleton organization	RAC1 RAC3	1.79e-03	35	37	2	GO:0099188
GeneOntologyBiologicalProcess	motor neuron axon guidance	RAC1 RAC3	1.79e-03	35	37	2	GO:0008045
GeneOntologyCellularComponent	focal adhesion	JAK2 TNS2 CD46 IGF2R ITGB2 RAC1	1.00e-04	431	37	6	GO:0005925
GeneOntologyCellularComponent	cell-substrate junction	JAK2 TNS2 CD46 IGF2R ITGB2 RAC1	1.17e-04	443	37	6	GO:0030055
GeneOntologyCellularComponent	ficolin-1-rich granule membrane	CR1 ITGB2 RAC1	1.71e-04	61	37	3	GO:0101003
GeneOntologyCellularComponent	secretory granule membrane	CD46 IGF2R CR1 ITGB2 RAC1	2.70e-04	329	37	5	GO:0030667
GeneOntologyCellularComponent	NADPH oxidase complex	RAC1 RAC3	4.58e-04	18	37	2	GO:0043020
Domain	Sushi	CD46 CR1 SVEP1	1.48e-04	52	37	3	PF00084
Domain	CCP	CD46 CR1 SVEP1	1.66e-04	54	37	3	SM00032
Domain	SUSHI	CD46 CR1 SVEP1	1.85e-04	56	37	3	PS50923
Domain	Sushi_SCR_CCP_dom	CD46 CR1 SVEP1	1.95e-04	57	37	3	IPR000436
Domain	RHO	RAC1 RAC3	7.09e-04	20	37	2	PS51420
Pathway	KEGG_MEDICUS_REFERENCE_ALTERNATIVE_PATHWAY_OF_COMPLEMENT_CASCADE_C3B_BREAKDOWN	CD46 CR1	3.26e-05	5	26	2	M47875
Pathway	WP_MICROGLIA_PATHOGEN_PHAGOCYTOSIS_PATHWAY	ITGB2 RAC1 RAC3	5.26e-05	40	26	3	M39695
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_GH_TO_ITGA_B_RHOA_SIGNALING_PATHWAY	RAC1 RAC3	6.83e-05	7	26	2	M47538
Pathway	WP_MICROGLIA_PATHOGEN_PHAGOCYTOSIS_PATHWAY	ITGB2 RAC1 RAC3	8.02e-05	46	26	3	MM15837
Pathway	WP_TROP2_REGULATORY_SIGNALING	JAK2 IGF2R RAC1	9.70e-05	49	26	3	M46458
Pathway	KEGG_MEDICUS_REFERENCE_IGG_FCGR_RAC_SIGNALING_PATHWAY	RAC1 RAC3	1.46e-04	10	26	2	M47727
Pathway	WP_RALA_DOWNSTREAM_REGULATED_GENES	RAC1 RAC3	2.13e-04	12	26	2	M39408
Pathway	WP_IL5_SIGNALING_PATHWAY	JAK2 ITGB2 RAC1	2.58e-04	68	26	3	MM15930
Pathway	KEGG_VIRAL_MYOCARDITIS	ITGB2 RAC1 RAC3	2.81e-04	70	26	3	M12294
Pathway	BIOCARTA_BLYMPHOCYTE_PATHWAY	CR1 ITGB2	2.94e-04	14	26	2	M1473
Pathway	KEGG_LEISHMANIA_INFECTION	JAK2 CR1 ITGB2	3.05e-04	72	26	3	M3126
Pathway	WP_COMPLEMENT_SYSTEM	CD46 CR1 ITGB2	7.10e-04	96	26	3	M39581
Pathway	WP_INTEGRINMEDIATED_CELL_ADHESION	ITGB2 RAC1 RAC3	8.47e-04	102	26	3	M39577
Pathway	WP_INTEGRINMEDIATED_CELL_ADHESION	ITGB2 RAC1 RAC3	8.47e-04	102	26	3	MM15830
Pathway	WP_COMPLEMENT_SYSTEM_IN_NEURONAL_DEVELOPMENT_AND_PLASTICITY	CD46 CR1 ITGB2	9.47e-04	106	26	3	M42535
Pathway	KEGG_MEDICUS_REFERENCE_CXCR4_GNB_G_RAC_SIGNALING_PATHWAY	RAC1 RAC3	1.03e-03	26	26	2	M47561
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNB_G_RAC_SIGNALING_PATHWAY	RAC1 RAC3	1.03e-03	26	26	2	M47562
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_RHOG_RAC_SIGNALING_PATHWAY	RAC1 RAC3	1.20e-03	28	26	2	M47655
Pathway	REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION	JAK2 KIF2B RAC1	1.23e-03	116	26	3	MM15715
Pathway	PID_S1P_S1P3_PATHWAY	JAK2 RAC1	1.29e-03	29	26	2	M55
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_FAK_RAC_SIGNALING_PATHWAY	RAC1 RAC3	1.38e-03	30	26	2	M47718
Pubmed	Rac-deficient cerebellar granule neurons die before they migrate to the internal granule layer.	RAC1 RAC3	1.10e-06	2	37	2	36050459
Pubmed	Rac1 and Rac3 have opposite functions in Schwann cells during developmental myelination.	RAC1 RAC3	1.10e-06	2	37	2	33812927
Pubmed	Identification of a Protein Network Driving Neuritogenesis of MGE-Derived GABAergic Interneurons.	RAC1 RAC3	1.10e-06	2	37	2	28066185
Pubmed	Rac-Dependent Signaling from Keratinocytes Promotes Differentiation of Intradermal White Adipocytes.	RAC1 RAC3	1.10e-06	2	37	2	31351086
Pubmed	Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion.	RAC1 RAC3	1.10e-06	2	37	2	16027728
Pubmed	Dispensable role of Rac1 and Rac3 after cochlear hair cell specification.	RAC1 RAC3	1.10e-06	2	37	2	37204479
Pubmed	Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells.	RAC1 RAC3	1.10e-06	2	37	2	16280046
Pubmed	Rac1 and Rac3 GTPases differently influence the morphological maturation of dendritic spines in hippocampal neurons.	RAC1 RAC3	1.10e-06	2	37	2	31369617
Pubmed	RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells.	RAC1 RAC3	1.10e-06	2	37	2	36599922
Pubmed	Absence of Rac1 and Rac3 GTPases in the nervous system hinders thymic, splenic and immune-competence development.	RAC1 RAC3	1.10e-06	2	37	2	21469092
Pubmed	Rac1 and Rac3 have opposing functions in cell adhesion and differentiation of neuronal cells.	RAC1 RAC3	1.10e-06	2	37	2	17244648
Pubmed	Perivascular deletion of murine Rac reverses the ratio of marrow arterioles and sinusoid vessels and alters hematopoiesis in vivo.	RAC1 RAC3	1.10e-06	2	37	2	25824687
Pubmed	Rac1 and Rac3 GTPases regulate the development of hilar mossy cells by affecting the migration of their precursors to the hilus.	RAC1 RAC3	1.10e-06	2	37	2	21949760
Pubmed	Natural IgM mediates complement-dependent uptake of Francisella tularensis by human neutrophils via complement receptors 1 and 3 in nonimmune serum.	CR1 ITGB2	1.10e-06	2	37	2	22888138
Pubmed	Loss of Either Rac1 or Rac3 GTPase Differentially Affects the Behavior of Mutant Mice and the Development of Functional GABAergic Networks.	RAC1 RAC3	1.10e-06	2	37	2	26582364
Pubmed	Monoclonal antibodies that recognize lacto-N-fucopentaose III (CD15) react with the adhesion-promoting glycoprotein family (LFA-1/HMac-1/gp 150,95) and CR1 on human neutrophils.	CR1 ITGB2	3.30e-06	3	37	2	3305706
Pubmed	Isoform-specific membrane targeting mechanism of Rac during Fc gamma R-mediated phagocytosis: positive charge-dependent and independent targeting mechanism of Rac to the phagosome.	RAC1 RAC3	3.30e-06	3	37	2	16081809
Pubmed	Signaling and cytoskeletal requirements in erythroblast enucleation.	RAC1 RAC3	3.30e-06	3	37	2	22461493
Pubmed	Protein tyrosine phosphatase receptor type γ is a JAK phosphatase and negatively regulates leukocyte integrin activation.	JAK2 ITGB2	3.30e-06	3	37	2	25624455
Pubmed	Altered Expression of Complement Regulatory Proteins CD35, CD46, CD55, and CD59 on Leukocyte Subsets in Individuals Suffering From Coronary Artery Disease.	CD46 CR1	3.30e-06	3	37	2	31555286
Pubmed	Novel role of Rac-Mid1 signaling in medial cerebellar development.	RAC1 RAC3	3.30e-06	3	37	2	28512198
Pubmed	RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways.	RAC1 RAC3	3.30e-06	3	37	2	33879799
Pubmed	JAK2-V617F promotes venous thrombosis through β1/β2 integrin activation.	JAK2 ITGB2	3.30e-06	3	37	2	30024857
Pubmed	rac, a novel ras-related family of proteins that are botulinum toxin substrates.	RAC1 RAC3	3.30e-06	3	37	2	2674130
Pubmed	Down-regulation of Rac activity during beta 2 integrin-mediated adhesion of human neutrophils.	ITGB2 RAC1	3.30e-06	3	37	2	12676940
Pubmed	Cucurbitacin I inhibits Rac1 activation in breast cancer cells by a reactive oxygen species-mediated mechanism and independently of Janus tyrosine kinase 2 and P-Rex1.	JAK2 RAC1	3.30e-06	3	37	2	23478800
Pubmed	Rho family GTPases, Rac and Cdc42, control the localization of neonatal dentate granule cells during brain development.	RAC1 RAC3	3.30e-06	3	37	2	30387892
Pubmed	Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic development.	RAC1 RAC3	3.30e-06	3	37	2	22123845
Pubmed	The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18.	RAC1 RAC3	3.30e-06	3	37	2	16982419
Pubmed	Pathophysiological Mechanisms in Neurodevelopmental Disorders Caused by Rac GTPases Dysregulation: What's behind Neuro-RACopathies.	RAC1 RAC3	3.30e-06	3	37	2	34943902
Pubmed	Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study.	CD46 CR1 ITGB2	5.38e-06	32	37	3	18842294
Pubmed	PAK is required for the disruption of E-cadherin adhesion by the small GTPase Rac.	RAC1 RAC3	6.60e-06	4	37	2	18319303
Pubmed	The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport.	IGF2R RAC1	6.60e-06	4	37	2	18596235
Pubmed	Use of complement regulators, CD35, CD46, CD55, and CD59, on leukocytes as markers for diagnosis of viral and bacterial infections.	CD46 CR1	6.60e-06	4	37	2	23376460
Pubmed	Gnb isoforms control a signaling pathway comprising Rac1, Plcβ2, and Plcβ3 leading to LFA-1 activation and neutrophil arrest in vivo.	ITGB2 RAC1	1.10e-05	5	37	2	26468229
Pubmed	Rac1 and rac3 GTPases control synergistically the development of cortical and hippocampal GABAergic interneurons.	RAC1 RAC3	1.10e-05	5	37	2	23258346
Pubmed	PTEN negatively regulates engulfment of apoptotic cells by modulating activation of Rac GTPase.	RAC1 RAC3	1.10e-05	5	37	2	22043008
Pubmed	Rac1 and Rac3 GTPases and TPC2 are required for axonal outgrowth and migration of cortical interneurons.	RAC1 RAC3	1.65e-05	6	37	2	36744839
Pubmed	Linkage analysis of the genetic determinants of T-cell IL-4 secretion, and identification of Flj20274 as a putative candidate gene.	JAK2 ZFAND5	1.65e-05	6	37	2	15815685
Pubmed	The regulation of the complement system: insights from genetically-engineered mice.	CD46 CR1	2.30e-05	7	37	2	12914820
Pubmed	Generation and characterization of Rac3 knockout mice.	RAC1 RAC3	3.07e-05	8	37	2	15964829
Pubmed	Role of the Rho GTPase Rac in the activation of the phagocyte NADPH oxidase: outsourcing a key task.	RAC1 RAC3	3.07e-05	8	37	2	24598074
Pubmed	Identification of potential nuclear reprogramming and differentiation factors by a novel selection method for cloning chromatin-binding proteins.	NSD1 SVEP1	3.07e-05	8	37	2	15522233
Pubmed	Negligible role of antibodies and C5 in pregnancy loss associated exclusively with C3-dependent mechanisms through complement alternative pathway.	CD46 CR1	3.07e-05	8	37	2	14670299
Pubmed	Vav GEFs are required for beta2 integrin-dependent functions of neutrophils.	ITGB2 RAC1	3.07e-05	8	37	2	15249579
Pubmed	CYBA encoding p22(phox), the cytochrome b558 alpha polypeptide: gene structure, expression, role and physiopathology.	RAC1 RAC3	3.07e-05	8	37	2	27048830
Pubmed	Regulation of lymphatic-blood vessel separation by endothelial Rac1.	RAC1 RAC3	4.93e-05	10	37	2	19906871
Pubmed	The human formin FHOD1 contains a bipartite structure of FH3 and GTPase-binding domains required for activation.	RAC1 RAC3	6.02e-05	11	37	2	18786395
Pubmed	Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling.	TNS2 ITGB2	7.22e-05	12	37	2	12606711
Pubmed	Several genes contribute to the production of autoreactive B and T cells in the murine lupus susceptibility locus Sle1c.	CD46 CR1	8.53e-05	13	37	2	16002709
Pubmed	Differential distribution of Rac1 and Rac3 GTPases in the developing mouse brain: implications for a role of Rac3 in Purkinje cell differentiation.	RAC1 RAC3	8.53e-05	13	37	2	14622142
Pubmed	Rac-GTPases Regulate Microtubule Stability and Axon Growth of Cortical GABAergic Interneurons.	RAC1 RAC3	8.53e-05	13	37	2	24626607
Pubmed	Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons.	RAC1 RAC3	9.94e-05	14	37	2	17409253
Pubmed	Essential role of Rac1 and Rac3 GTPases in neuronal development.	RAC1 RAC3	9.94e-05	14	37	2	19126596
Pubmed	CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration.	ITGB2 RAC1	2.07e-04	20	37	2	23620790
Pubmed	Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.	TNS2 CD46 IGF2R RAC1	2.36e-04	285	37	4	21423176
Pubmed	Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring.	RAC1 RAC3	3.52e-04	26	37	2	39152101
Pubmed	Redundant functions of Rac GTPases in inner ear morphogenesis.	RAC1 RAC3	3.52e-04	26	37	2	22182523
Pubmed	The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present.	MRPS30 MRPS18C	5.02e-04	31	37	2	11279123
Pubmed	Risk of non-Hodgkin lymphoma in association with germline variation in complement genes.	CD46 CR1	5.02e-04	31	37	2	19344414
Pubmed	Lacrimal gland budding requires PI3K-dependent suppression of EGF signaling.	IGF2R RAC1	5.35e-04	32	37	2	34193412
Pubmed	Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.	NSD1 KDM4A	5.69e-04	33	37	2	26864203
Pubmed	DNA sequence and analysis of human chromosome 9.	C9orf85 JAK2 ZFAND5 ADAMTSL1	6.31e-04	370	37	4	15164053
GeneFamily	Complement system\|Sushi domain containing	CD46 CR1 ITGB2	2.56e-05	36	29	3	492
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CD46 CR1 SVEP1	1.02e-04	57	29	3	1179
GeneFamily	Rho family GTPases	RAC1 RAC3	4.64e-04	20	29	2	390
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	CD46 IGF2R CR1 ITGB2	3.43e-03	394	29	4	471
GeneFamily	Mitochondrial ribosomal proteins	MRPS30 MRPS18C	7.09e-03	79	29	2	646
GeneFamily	SH2 domain containing	JAK2 TNS2	1.14e-02	101	29	2	741
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TNS2 ADAMTSL1 SVEP1 PCOLCE	1.51e-05	181	37	4	6d1f1ad35778a2a227f966f11f6edd8e89452576
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTSL1 SVEP1 LGI1 PCOLCE	1.90e-05	192	37	4	c3707243c5590d852c9f28429c96f50a1fa6b0dc
ToppCell	severe-Myeloid-Neutrophils_3\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CD46 IGF2R CR1 ITGB2	1.94e-05	193	37	4	f4d43dfbf4115dd0f843ea5cf08049220342a047
ToppCell	severe-Myeloid-Neutrophils_3\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CD46 IGF2R CR1 ITGB2	1.98e-05	194	37	4	1f8edab1c8ba48bc0114429ea47aab378b5830b7
ToppCell	(05)_Secretory-(2)_GFP_FOXI1\|(05)_Secretory / shred by cell type by condition	COX17 ZFAND5 CD46 RAC1	2.19e-05	199	37	4	d72d87e1e530ed894c0ad5e7b5b2b1d6b59fa098
ToppCell	10x3'2.3-week_12-13-Mesenchymal_fibro-stroma-arteriolar_fibroblast\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	TNS2 ADAMTSL1 GAS2 PCOLCE	2.23e-05	200	37	4	fee22a6a6c7b93af204b5b56f2c34f1411500e18
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_26.46.91\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTSL1 TRHR SVEP1	1.67e-04	129	37	3	6abdba987c8528f7cb90b32dc01796e02c7352c9
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTSL1 SVEP1 HEATR9	2.30e-04	144	37	3	cf9f049ab6cd80521598124f057c2debdde24788
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_104\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTSL1 SVEP1 HEATR9	2.30e-04	144	37	3	41eaeca54b3c39de417597267cbdb1f195dd885a
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KCNK18 ZNF69 FSIP2	2.65e-04	151	37	3	16fc903fc71e25717b9908416f0bcd29c0a65a61
ToppCell	367C-Fibroblasts-Fibroblast-D-\|367C / Donor, Lineage, Cell class and subclass (all cells)	ADAM29 SVEP1 PCOLCE	2.81e-04	154	37	3	dd3d34f065820e706515a13619f19a5b12734c8e
ToppCell	367C-Fibroblasts-Fibroblast-D\|367C / Donor, Lineage, Cell class and subclass (all cells)	ADAM29 SVEP1 PCOLCE	2.81e-04	154	37	3	4bfda1c41efbb86d829b3797d1168bf2587c3c97
ToppCell	facs-Aorta-Heart-18m-Mesenchymal-fibrocyte\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNT14 ITGB2 LGI1	2.91e-04	156	37	3	5b56217336771baf57d791efcb4e206c6aea83b1
ToppCell	frontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Spp1_Col15a1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TNS2 SVEP1 PCOLCE	3.08e-04	159	37	3	34c90711c5857cf6ada7b3acff99f1d48c7caf29
ToppCell	Adult-Mesenchymal-chondrocyte\|Adult / Lineage, Cell type, age group and donor	TNS2 SVEP1 PCOLCE	3.08e-04	159	37	3	3f7305ee76447064b5c846c4f576360a2f7e0b7c
ToppCell	368C-Fibroblasts-Fibroblast-E\|368C / Donor, Lineage, Cell class and subclass (all cells)	RNF217 SVEP1 PCOLCE	3.25e-04	162	37	3	e17632778a57c71d6005d3abca3a0443a92040e7
ToppCell	droplet-Lung-nan-3m-Lymphocytic-NK_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGB2 RAC3 HEATR9	3.25e-04	162	37	3	4b490989005bb03d4e7bbea01580f8548eff150f
ToppCell	368C-Fibroblasts-Fibroblast-E-\|368C / Donor, Lineage, Cell class and subclass (all cells)	RNF217 SVEP1 PCOLCE	3.25e-04	162	37	3	ac4a80fd72c9311ea2b3e574c6284bbce4f2756c
ToppCell	droplet-Lung-nan-3m-Lymphocytic-Natural_Killer\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGB2 RAC3 HEATR9	3.25e-04	162	37	3	e4a09bf1a51710f6c57e6e01edf8b4619459d96d
ToppCell	droplet-Spleen-nan-3m-Lymphocytic-NK_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGB2 RAC3 HEATR9	3.31e-04	163	37	3	2e1c1193c04620cc187b1567dfba025beef1e4e1
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MEIOSIN ADAMTSL1 PCOLCE	3.56e-04	167	37	3	d50311b1f66f143bae4c4cf50e2e9b13c85d6920
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MEIOSIN ADAMTSL1 PCOLCE	3.56e-04	167	37	3	7abc785e688a384672d7fb5a62d32538fe7e5a51
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_104\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TNS2 SVEP1 PCOLCE	3.68e-04	169	37	3	6ff1172da690ca17f7108f1617b255b766971a57
ToppCell	(07)_Ionocytes-(2)_GFP_FOXI1\|(07)_Ionocytes / shred by cell type by condition	COX17 CD46 RAC1	3.88e-04	172	37	3	5776b638b845d054f6e884e7df0412477f48517d
ToppCell	PND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_DCN\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	ADAMTSL1 LGI1 PCOLCE	4.15e-04	176	37	3	08f94b78b27feeb113dbfadbfa7fe34d08b2809b
ToppCell	356C-Fibroblasts-Fibroblast-E-\|356C / Donor, Lineage, Cell class and subclass (all cells)	ADAMTSL1 SVEP1 PCOLCE	4.29e-04	178	37	3	a493a277d175e5e153410a745b26ebe2e0839ea0
ToppCell	356C-Fibroblasts-Fibroblast-E\|356C / Donor, Lineage, Cell class and subclass (all cells)	ADAMTSL1 SVEP1 PCOLCE	4.29e-04	178	37	3	371218babddfd3d8a7bb82a46ce65327ee3fcf12
ToppCell	facs-Pancreas-Endocrine-24m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 SVEP1 PCOLCE	4.36e-04	179	37	3	6f51a4580c06fc55cc764052c9b26f7c55660282
ToppCell	facs-Pancreas-Endocrine-24m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 SVEP1 PCOLCE	4.36e-04	179	37	3	a6ce1fa338d4905bd6afef00763ac83e916a0b37
ToppCell	E15.5-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IGF2R SVEP1 PCOLCE	4.36e-04	179	37	3	b559f5a72cc9e3e35d05cb539b5c2e006e56e652
ToppCell	facs-Pancreas-Endocrine-24m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 SVEP1 PCOLCE	4.36e-04	179	37	3	f14440f6ce9b4fcdd4bcb2488b949f9a0e17bc23
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CD46 TRHR ATP2C2	4.50e-04	181	37	3	576da14ab3107f89e1f44a4a439d1bef5bb42370
ToppCell	facs-Pancreas-Exocrine-18m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 SVEP1 PCOLCE	4.50e-04	181	37	3	269b39ac65790061d54eab47a8eeb024403f0348
ToppCell	facs-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 SVEP1 PCOLCE	4.50e-04	181	37	3	cd4f744b6b64ba6c22ec07afd1d3058a2546909d
ToppCell	facs-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 SVEP1 PCOLCE	4.50e-04	181	37	3	c8395ae872aa80b3ae1ab7c53e57b3ca15aeb0e2
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 SVEP1 PCOLCE	4.79e-04	185	37	3	3cd0686a14e734a0f243070ab939adcb4c454478
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 SVEP1 PCOLCE	4.79e-04	185	37	3	00258f458cbf6d36449db95528a6b5038d731d2d
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 SVEP1 PCOLCE	4.79e-04	185	37	3	a94694e226856bc5b168464f52d76004145717a5
ToppCell	facs-Thymus-Epithelium-24m-Mesenchymal-fibroblast\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNS2 SVEP1 PCOLCE	4.79e-04	185	37	3	eaa54b76743628c89b4310be57b87fa92b75fd37
ToppCell	facs-Thymus-Epithelium-24m-Mesenchymal-fibroblast\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNS2 SVEP1 PCOLCE	4.79e-04	185	37	3	f7f4c921d248c637351e2e882589b99ba7f04b66
ToppCell	facs-Skin-nan-24m-Mesenchymal\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SVEP1 LGI1 PCOLCE	4.79e-04	185	37	3	8433a337625ff8398520e223ef92bf9bb0beb14c
ToppCell	facs-Skin-nan-24m-Mesenchymal-fibroblast\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SVEP1 LGI1 PCOLCE	4.79e-04	185	37	3	049d793d043d5d434f143025de49dd210d18756c
ToppCell	facs-Thymus-Epithelium-24m-Mesenchymal\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNS2 SVEP1 PCOLCE	4.79e-04	185	37	3	ff38a15af3dec36d9993f06623591872b5d1da9a
ToppCell	facs-Skin-nan-24m-Mesenchymal-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SVEP1 LGI1 PCOLCE	4.79e-04	185	37	3	63200c42565eea596f9b00728e70e544b8d50a7f
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 SVEP1 PCOLCE	4.95e-04	187	37	3	4e553721fa5598cb211f44e3226280b7e6885484
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 SVEP1 PCOLCE	4.95e-04	187	37	3	d36e7fc6125e7a4310499365022d38f34b757a73
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 SVEP1 PCOLCE	4.95e-04	187	37	3	827eae63fabf6892a82ce7779b5f395958d3d628
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ZFAND5 IGF2R CR1	5.02e-04	188	37	3	5f6ad5d693145d846ca561c2fa55465a88e40b90
ToppCell	E16.5-samps-Mesenchymal\|E16.5-samps / Age Group, Lineage, Cell class and subclass	IGF2R SVEP1 PCOLCE	5.02e-04	188	37	3	3f0f662be684e3a4c6652e636cc135a39a1d2790
ToppCell	facs-Skin-nan-18m-Mesenchymal-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 SVEP1 PCOLCE	5.10e-04	189	37	3	29287525120be2953b76881ba3cfc4379c265e7a
ToppCell	facs-Skin-nan-18m-Mesenchymal-fibroblast\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 SVEP1 PCOLCE	5.10e-04	189	37	3	7150dad9a92a715487c2d8130fa01b752ea69663
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAMTSL1 SVEP1 PCOLCE	5.10e-04	189	37	3	d531399749409d614adca13d181830c6e3287508
ToppCell	E18.5-samps-Mesenchymal\|E18.5-samps / Age Group, Lineage, Cell class and subclass	IGF2R SVEP1 PCOLCE	5.10e-04	189	37	3	0c18d3de4720759cf802eefb4d0ddde2a9246a1a
ToppCell	facs-Skin-nan-18m-Mesenchymal\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 SVEP1 PCOLCE	5.10e-04	189	37	3	6e4c0effd5192fd00052abc048fdb87a74fb6554
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTSL1 SVEP1 GAS2	5.18e-04	190	37	3	bb3b396d78887d5d6f93a05c8ed4d703591bf33f
ToppCell	5'-Adult-LymphNode-Mesenchymal\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZFAND5 SVEP1 PCOLCE	5.26e-04	191	37	3	054e9a79bd1486fd812bc7418fb091664fe3a646
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZFAND5 RNF217 SVEP1	5.26e-04	191	37	3	2c51850f5c559d665b8a27a12b75af9ed58dffe1
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 SVEP1 PCOLCE	5.34e-04	192	37	3	ac1477433704573f95111eee6263b93668d2845e
ToppCell	facs-Lung-nan-3m-Mesenchymal-Adventitial_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 SVEP1 PCOLCE	5.34e-04	192	37	3	a2c31390da4962bda9a936470b0b68fa1f5d47d1
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADAMTSL1 SVEP1 PCOLCE	5.34e-04	192	37	3	e0f4e4470a71bfa81d9dcd8594e5f82aafc24f81
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-adventitial_fibroblast\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTSL1 SVEP1 PCOLCE	5.34e-04	192	37	3	f9fb24457999dc9e751a099d7f995543b9330ad4
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 SVEP1 PCOLCE	5.34e-04	192	37	3	8937a59f6bbe07f671bdabbd3707dc9c17a14cd9
ToppCell	Mesenchymal-matrix_fibroblast_2_cell\|World / Lineage, Cell type, age group and donor	ADAMTSL1 SVEP1 PCOLCE	5.34e-04	192	37	3	a769158c49d2b208c4224d85e7ae68c85cc372ed
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTSL1 SVEP1 PCOLCE	5.34e-04	192	37	3	7b48df661f61ce494bf6f0b9a74b0422e29c24bf
ToppCell	facs-Lung-nan-3m-Mesenchymal-adventitial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 SVEP1 PCOLCE	5.34e-04	192	37	3	eeab1cef7c36ae824381952c5b2c982368c379fd
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 SVEP1 PCOLCE	5.34e-04	192	37	3	e4a7f2673f801b008ca67291db2fb2b9fd2955b8
ToppCell	3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TNS2 ZFAND5 SVEP1	5.34e-04	192	37	3	11867f30f0b420c18cb0b34d3990237aa737a0e8
ToppCell	facs-Lung-EPCAM-18m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGB2 SVEP1 PCOLCE	5.42e-04	193	37	3	b9ac74357435f2f24aaede62b2a1d31b5d96a12c
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADAMTSL1 SVEP1 PCOLCE	5.42e-04	193	37	3	9ab47b360bee1d4f1092c2269e58acebe9584021
ToppCell	Children_(3_yrs)-Immune-monocyte-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	JAK2 CR1 ITGB2	5.42e-04	193	37	3	58e1930a1d80ad3729ab9604ac8ebf7308232a3d
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTSL1 SVEP1 PCOLCE	5.42e-04	193	37	3	9d0b966d13cbce97beb43de6dc77f006c363a181
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	WFDC8 SVEP1 PCOLCE	5.51e-04	194	37	3	79baee8b35b7707bbeb07c73b5e17b68bcd7bbc2
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibro-meso\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	WFDC8 SVEP1 PCOLCE	5.51e-04	194	37	3	f6e348f1f35c526cad6c349f1fdd0bd92d18aa3c
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ZFAND5 CR1 ITGB2	5.51e-04	194	37	3	5022c85ad3b137dae4b9ff11f9c23bb3bf4c0f5a
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell-Mesothelium-Mesothelium_L.2.6.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	WFDC8 SVEP1 PCOLCE	5.51e-04	194	37	3	421344cc4b601d9745fa72d0af3124dab11d1d27
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell-Mesothelium\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	WFDC8 SVEP1 PCOLCE	5.51e-04	194	37	3	ce599ed0dc181aea0584e426636de5098f34ebe6
ToppCell	facs-GAT-Fat-3m-Mesenchymal-mesenchymal_progenitor\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 SVEP1 PCOLCE	5.59e-04	195	37	3	69a29d03e664b72f32d41876510c62345c3aed31
ToppCell	343B-Myeloid-Monocyte\|343B / Donor, Lineage, Cell class and subclass (all cells)	ZFAND5 CR1 ITGB2	5.59e-04	195	37	3	169b4952118ca5ded55de928a1cf08721cdac193
ToppCell	facs-GAT-Fat-3m-Mesenchymal\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 SVEP1 PCOLCE	5.59e-04	195	37	3	1cffae2b08dbfa1c633ce24023e89b66d28b5431
ToppCell	facs-GAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 SVEP1 PCOLCE	5.59e-04	195	37	3	9cef6f18664518060af7c192310dddce6d70345a
ToppCell	mild-Myeloid-Neutrophils_3\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CD46 IGF2R CR1	5.67e-04	196	37	3	9c351306b6aae68ed47d4cb1911957bf67f9e1ae
ToppCell	COVID-19_Mild-Classical_Monocyte-cMono_3\|COVID-19_Mild / Disease condition and Cell class	IGF2R CR1 ITGB2	5.67e-04	196	37	3	f245e929a286cb097130572e1027b4f01be8b04d
ToppCell	droplet-Limb_Muscle-nan-24m-Mesenchymal-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SVEP1 GAS2 PCOLCE	5.67e-04	196	37	3	61bee32ca299219f31a30b57124e44e85b798e9f
ToppCell	IPF-Stromal-Fibroblast\|IPF / Disease state, Lineage and Cell class	ADAMTSL1 SVEP1 PCOLCE	5.67e-04	196	37	3	f7ae604ba32b322d86d68b2b54892e7c6ab06c49
ToppCell	COVID-19_Mild-Classical_Monocyte-cMono_3\|Classical_Monocyte / Disease condition and Cell class	IGF2R CR1 ITGB2	5.67e-04	196	37	3	15397ec27167bb2fb6fec120b68bf38fc71b2670
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IGF2R SVEP1 PCOLCE	5.67e-04	196	37	3	97e26622d9582b092c18ff5b7e957818f99d9631
ToppCell	droplet-Limb_Muscle-nan-18m-Mesenchymal-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SVEP1 GAS2 PCOLCE	5.67e-04	196	37	3	fcb275746bf51269ed8ba4cf93edb054a45f1ccd
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IGF2R SVEP1 PCOLCE	5.67e-04	196	37	3	f429f045ba45e24717963315832150b12a115bfa
ToppCell	BL\|World / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	IGF2R CR1 ITGB2	5.76e-04	197	37	3	1acf0191fa0a25cd20bfd9ea7bf727a1555986a1
ToppCell	10x3'2.3-week_17-19-Mesenchymal_adipo-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	TNS2 SVEP1 PCOLCE	5.76e-04	197	37	3	b9745e382baa2725dfcae060701fb53f6c8a31fa
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TNS2 SVEP1 PCOLCE	5.76e-04	197	37	3	17344464fdcc5ba0c03959696b97c195f11e644c
ToppCell	10x3'2.3-week_14-16-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	TNS2 SVEP1 PCOLCE	5.76e-04	197	37	3	c165c6fd12dc649b39e920d8528e2eb65c61956b
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal-mesenchymal_stem_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TNS2 SVEP1 PCOLCE	5.76e-04	197	37	3	3bb92dd8a94e2be3b7fe51c9a21b241215477ac7
ToppCell	10x3'2.3-week_17-19-Mesenchymal_adipo\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	TNS2 SVEP1 PCOLCE	5.76e-04	197	37	3	5afddde4e2b5cd55abe11e9b9efae02dbdc3da3a
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMTSL1 GAS2 PCOLCE	5.76e-04	197	37	3	5f6fce382f273e789ffbb75b63e9b4e87519918e
ToppCell	10x3'2.3-week_17-19-Mesenchymal_adipo-stroma-adipo-CAR\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	TNS2 SVEP1 PCOLCE	5.76e-04	197	37	3	1baffd087ca194a7355fefbb3bf67befb14fe2de
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TNS2 SVEP1 PCOLCE	5.76e-04	197	37	3	5b8d0d7116b20d8e27541e88ec80c9f1f477e384
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TNS2 SVEP1 PCOLCE	5.76e-04	197	37	3	ad6c200a193a15360d17463e18a465ce1b90b8da
ToppCell	severe-Others-Megakaryocytes\|Others / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	IGF2R CR1 ITGB2	5.76e-04	197	37	3	fc0864e2de2d9f99084586b467551b6da535d933
ToppCell	10x3'2.3-week_14-16-Mesenchymal_adipo-stroma-adipo-CAR\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	RNF217 SVEP1 PCOLCE	5.84e-04	198	37	3	a8c21f4db6730d0aa05b61fbe72bf9f7571a9015
Drug	Josamycin	CR1 ITGB2	2.57e-06	2	37	2	ctd:D015570
Drug	H-89, Dihydrochloride; Up 200; 0.5uM; PC3; HT_HG-U133A	JAK2 KDM4A IGF2R ITGB2 ATP2C2	1.49e-05	194	37	5	6921_UP
Disease	autosomal dominant intellectual developmental disorder 48 (implicated_via_orthology)	RAC1 RAC3	4.34e-06	3	36	2	DOID:0080235 (implicated_via_orthology)
Disease	colon adenocarcinoma (is_marker_for)	JAK2 RAC1	4.27e-04	25	36	2	DOID:234 (is_marker_for)
Disease	response to perphenazine	MRPS30 LGI1	4.62e-04	26	36	2	GO_0097334
Disease	Heart valve disease	JAK2 ITGB2	4.62e-04	26	36	2	C0018824
Disease	colon adenocarcinoma (is_implicated_in)	JAK2 RAC1	4.62e-04	26	36	2	DOID:234 (is_implicated_in)
Disease	multiple myeloma (is_marker_for)	CD46 IGF2R	8.88e-04	36	36	2	DOID:9538 (is_marker_for)
Disease	epilepsy (implicated_via_orthology)	KCNK18 RAC1 LGI1	1.03e-03	163	36	3	DOID:1826 (implicated_via_orthology)
Disease	complement factor H-related protein 3 measurement	DIP2C KIF2B RAC1	1.15e-03	169	36	3	EFO_0600056
Disease	kidney disease (implicated_via_orthology)	RAC1 RAC3	1.15e-03	41	36	2	DOID:557 (implicated_via_orthology)
Disease	Microcalcification	JAK2 ITGB2	1.21e-03	42	36	2	C0521174
Disease	Calcinosis	JAK2 ITGB2	1.21e-03	42	36	2	C0006663
Disease	Tumoral calcinosis	JAK2 ITGB2	1.21e-03	42	36	2	C0263628
Disease	nasopharynx carcinoma (is_marker_for)	JAK2 RAC1	1.27e-03	43	36	2	DOID:9261 (is_marker_for)
Disease	dimethylglycine measurement	GALNT14 ADAMTSL1	1.45e-03	46	36	2	EFO_0010476
Disease	oropharynx cancer	JAK2 GALNT14	1.45e-03	46	36	2	EFO_1001931
Disease	smoking status measurement, carotid artery intima media thickness	DIP2C KIF2B	1.58e-03	48	36	2	EFO_0006527, EFO_0007117
Disease	Premature atrial contractions	ZNF69 ZNF440	2.06e-03	55	36	2	HP_0006699
Disease	response to paliperidone, schizophrenia symptom severity measurement	ADAMTSL1 CR1 KIF2B	2.31e-03	216	36	3	EFO_0007925, EFO_0007927
Disease	breast carcinoma (is_marker_for)	CD46 IGF2R	2.96e-03	66	36	2	DOID:3459 (is_marker_for)
Disease	parental longevity	GALNT14 CD46 IGF2R KIF2B	2.99e-03	494	36	4	EFO_0007796
Disease	Alzheimer disease, educational attainment	MRPS30 MEIOSIN CR1	3.37e-03	247	36	3	EFO_0011015, MONDO_0004975

Protein segments in the cluster

Peptide	Gene	Start	Entry
PPPKRKKKKKFCYLC	ADAM29	666	Q9UKF5
EKKPLKPCCACPETK	COX17	16	Q14061
EKKVTALPPKEACKC	ATP2C2	46	O75185
ELPFCQPKKKSTPLK	NSD1	306	Q96L73
KFYVPCKQCPPMKKG	PCOLCE	381	Q15113
VLCPPPVKKPGKKCT	RAC3	176	P60763
VLCPPPVKKRKRKCL	RAC1	176	P63000
IIFQFTKCCPPKPKD	JAK2	491	O60674
TKCCPPKPKDKSNLL	JAK2	496	O60674
CPKSLFKKKPDPKPA	KCNK18	181	Q7Z418
ICEKVLCTPPPKIKN	CD46	156	P15529
TCFECKRNIKPPTKP	FSIP2	1041	Q5CZC0
KPKPKLQECNLDPCP	ADAMTSL1	346	Q8N6G6
IPLPRFKLKCIFCKK	KDM4A	821	O75164
KKGPCPPQMKKKCVN	MEIOSIN	531	C9JSJ3
PDDCKQLIKLPKVKC	GALNT14	156	Q96FL9
KLRNPCPNKEKECQP	ITGB2	186	P05107
KDVCKRKSCKTPPDP	CR1	546	P17927
KDVCKRKSCKTPPDP	CR1	996	P17927
DLPKKRPAQICKPCN	DIP2C	1116	Q9Y2E4
YKPLSKPKKCVKCLQ	C9orf85	61	Q96MD7
PSKPCLMKQKKSPCL	KIF2B	136	Q8N4N8
VKRISEDPPCKCPNK	GAS2	206	O43903
VCPPKKLECKFVQKH	IGF2R	1986	P11717
IPTIKCKPDKLPLFK	MRPS30	261	Q9NP92
FRKLCNCKQKPTEKP	TRHR	331	P34981
CLEDKPIKPLPCCKK	RNF217	266	Q8TC41
PIKPLPCCKKAVCEE	RNF217	271	Q8TC41
NKKSNPKCMPAKCPE	SVEP1	2311	Q4LDE5
NPYKEPLKKCILCGK	MRPS18C	56	Q9Y3D5
VKKGFCPRKPLLCTK	WFDC8	196	Q8IUA0
CPRKPLLCTKIDKPK	WFDC8	201	Q8IUA0
PKPCKCQQPKKAFRY	ZNF440	141	Q8IYI8
EKAPELPKPKKNRCF	ZFAND5	141	O76080
KTKDPCAPQVKKQCP	SPRR4	41	Q96PI1
KKTPAFPPCCSKPRK	HEATR9	531	A2RTY3
PVCPLCKKPFKKENI	TRIM26	51	Q12899
PKPCKCQQPKKAFRY	ZNF69	161	Q9UC07
KVFKQEKGKQPPCPK	ZNF330	201	Q9Y3S2
EKVFRKKPPVCAVCK	TNS2	36	Q63HR2
KPAKPKCPAVCTCTK	LGI1	36	O95970