Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbitter taste receptor activity

TAS2R33 TAS2R31 TAS2R43 TAS2R46

7.42e-0727534GO:0033038
GeneOntologyMolecularFunctiontaste receptor activity

TAS2R33 TAS2R31 TAS2R43 TAS2R46

1.71e-0633534GO:0008527
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of bitter taste

TAS2R33 TAS2R31 TAS2R43 TAS2R46

5.27e-0644544GO:0001580
GeneOntologyBiologicalProcesssensory perception of bitter taste

TAS2R33 TAS2R31 TAS2R43 TAS2R46

7.49e-0648544GO:0050913
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of taste

TAS2R33 TAS2R31 TAS2R43 TAS2R46

8.84e-0650544GO:0050912
GeneOntologyBiologicalProcessNLS-bearing protein import into nucleus

RGPD2 RGPD8 RGPD5

1.87e-0520543GO:0006607
GeneOntologyBiologicalProcesssensory perception of taste

TAS2R33 TAS2R31 TAS2R43 TAS2R46

3.38e-0570544GO:0050909
GeneOntologyBiologicalProcesspositive regulation of glucokinase activity

RGPD2 RGPD8

2.39e-049542GO:0033133
GeneOntologyBiologicalProcesspositive regulation of hexokinase activity

RGPD2 RGPD8

2.99e-0410542GO:1903301
GeneOntologyCellularComponentcytoplasmic periphery of the nuclear pore complex

RGPD2 RGPD8

1.82e-048542GO:1990723
GeneOntologyCellularComponentnuclear pore cytoplasmic filaments

RGPD2 RGPD8

2.91e-0410542GO:0044614
GeneOntologyCellularComponentmotile cilium

MET ROPN1L DNAH17 TAS2R31 TAS2R43 TAS2R46

2.99e-04355546GO:0031514
GeneOntologyCellularComponentannulate lamellae

RGPD2 RGPD8

5.84e-0414542GO:0005642
GeneOntologyCellularComponentnuclear pore nuclear basket

RGPD2 RGPD8

9.76e-0418542GO:0044615
GeneOntologyCellularComponentnuclear inclusion body

RGPD2 RGPD8

1.21e-0320542GO:0042405
GeneOntologyCellularComponentSUMO ligase complex

RGPD2 RGPD8

1.33e-0321542GO:0106068
DomainGrip

RGPD2 RGPD8 RGPD5

3.31e-0611523SM00755
DomainGRIP

RGPD2 RGPD8 RGPD5

3.31e-0611523PF01465
DomainRan_BP1

RGPD2 RGPD8 RGPD5

4.40e-0612523PF00638
DomainGRIP_dom

RGPD2 RGPD8 RGPD5

4.40e-0612523IPR000237
DomainGRIP

RGPD2 RGPD8 RGPD5

4.40e-0612523PS50913
DomainRANBD1

RGPD2 RGPD8 RGPD5

4.40e-0612523PS50196
DomainRanBD

RGPD2 RGPD8 RGPD5

5.71e-0613523SM00160
DomainRan_bind_dom

RGPD2 RGPD8 RGPD5

5.71e-0613523IPR000156
DomainTAS2R

TAS2R31 TAS2R43 TAS2R46

5.06e-0526523PF05296
DomainT2R

TAS2R31 TAS2R43 TAS2R46

5.06e-0526523IPR007960
DomainGCC2_Rab_bind

RGPD2 RGPD8

1.58e-047522IPR032023
DomainRab_bind

RGPD2 RGPD8

1.58e-047522PF16704
Domain-

RGPD2 RGPD8

3.37e-04105221.10.220.60
DomainTPR-contain_dom

RGPD2 RGPD8 UTY RGPD5

8.02e-04150524IPR013026
DomainTPR_REGION

RGPD2 RGPD8 UTY RGPD5

1.14e-03165524PS50293
DomainTPR

RGPD2 RGPD8 UTY RGPD5

1.14e-03165524PS50005
DomainTPR_1

RGPD8 UTY RGPD5

2.02e-0390523PF00515
DomainTPR_1

RGPD8 UTY RGPD5

2.02e-0390523IPR001440
DomainTPR-like_helical_dom

RGPD2 RGPD8 UTY RGPD5

4.00e-03233524IPR011990
DomainTPR

RGPD2 RGPD8 UTY

5.56e-03129523SM00028
DomainTPR_repeat

RGPD2 RGPD8 UTY

6.05e-03133523IPR019734
DomainPH_dom-like

RGPD2 SHC2 RGPD8 PLEKHA8 RGPD5

6.50e-03426525IPR011993
PathwayREACTOME_SENSORY_PERCEPTION_OF_TASTE

TAS2R31 TAS2R43 TAS2R46

8.34e-0531393MM15691
PathwayREACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS

TAS2R31 TAS2R43 TAS2R46

1.43e-0437393MM15067
PathwayREACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS

TAS2R31 TAS2R43 TAS2R46

1.67e-0439393M793
PathwayREACTOME_SENSORY_PERCEPTION_OF_TASTE

TAS2R31 TAS2R43 TAS2R46

2.92e-0447393M42524
PathwayKEGG_TASTE_TRANSDUCTION

TAS2R31 TAS2R43 TAS2R46

3.94e-0452393M5785
Pubmed

Complex genomic rearrangements lead to novel primate gene function.

RGPD2 RGPD8 RGPD5

1.23e-07754315710750
Pubmed

The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.

TAS2R31 TAS2R43 TAS2R46

7.71e-071254312379855
Pubmed

Identification and characterization of human taste receptor genes belonging to the TAS2R family.

TAS2R31 TAS2R43 TAS2R46

1.00e-061354312584440
Pubmed

Haplotypes at the Tas2r locus on distal chromosome 6 vary with quinine taste sensitivity in inbred mice.

TAS2R31 TAS2R43 TAS2R46

1.00e-061354315938754
Pubmed

Bitter taste receptors for saccharin and acesulfame K.

TAS2R31 TAS2R43

2.37e-06254215537898
Pubmed

Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin.

TAS2R31 TAS2R43

2.37e-06254217702579
Pubmed

MondoA Is an Essential Glucose-Responsive Transcription Factor in Human Pancreatic β-Cells.

MLXIPL MLXIP

2.37e-06254229282201
Pubmed

Glucose-dependent transcriptional regulation by an evolutionarily conserved glucose-sensing module.

MLXIPL MLXIP

2.37e-06254216644671
Pubmed

Contrasting Patterns in the Evolution of Vertebrate MLX Interacting Protein (MLXIP) and MLX Interacting Protein-Like (MLXIPL) Genes.

MLXIPL MLXIP

2.37e-06254226910886
Pubmed

A novel family of mammalian taste receptors.

TAS2R31 TAS2R43 TAS2R46

4.61e-062154310761934
Pubmed

Evolutionary relationships of the Tas2r receptor gene families in mouse and human.

TAS2R31 TAS2R43 TAS2R46

5.34e-062254312734386
Pubmed

The molecular receptive ranges of human TAS2R bitter taste receptors.

TAS2R31 TAS2R43 TAS2R46

6.13e-062354320022913
Pubmed

TXNIP induced by MondoA, rather than ChREBP, suppresses cervical cancer cell proliferation, migration and invasion.

MLXIPL MLXIP

7.09e-06354231782782
Pubmed

FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver.

MLXIPL KLB

7.09e-06354226724858
Pubmed

Receptors for bitter and sweet taste.

TAS2R31 TAS2R43 TAS2R46

7.94e-062554312139982
Pubmed

Molecular mechanisms of bitter and sweet taste transduction.

TAS2R31 TAS2R43 TAS2R46

8.97e-062654311696554
Pubmed

Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.

TAS2R31 TAS2R43 TAS2R46

1.01e-052754312581520
Pubmed

Adaptive diversification of bitter taste receptor genes in Mammalian evolution.

TAS2R31 TAS2R43 TAS2R46

1.39e-053054312679530
Pubmed

Mapping of QTLs for oral alcohol self-administration in B6.C and B6.I quasi-congenic RQI strains.

TAS2R31 TAS2R43 TAS2R46

1.39e-053054317273929
Pubmed

Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12.

RGPD8 RGPD5

1.42e-0545429480752
Pubmed

Evolution of bitter taste receptors in humans and apes.

TAS2R31 TAS2R43 TAS2R46

2.05e-053454315496549
Pubmed

MondoA-Mlx transcriptional activity is limited by mTOR-MondoA interaction.

MLXIPL MLXIP

2.36e-05554225332233
Pubmed

Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.

RGPD2 RGPD8

4.94e-05754230944974
Pubmed

Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.

RGPD2 RGPD8

4.94e-05754238838144
Pubmed

Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.

RGPD2 RGPD8

4.94e-05754221205196
Pubmed

Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.

RGPD2 RGPD8

4.94e-05754218949001
Pubmed

QTL analysis of dietary obesity in C57BL/6byj X 129P3/J F2 mice: diet- and sex-dependent effects.

MRPL28 MMUT

4.94e-05754223922663
Pubmed

Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.

RGPD2 RGPD8

4.94e-05754225187515
Pubmed

Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.

RGPD2 RGPD8

4.94e-0575429037092
Pubmed

Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.

RGPD2 RGPD8

4.94e-05754223536549
Pubmed

Expression of P2Y(6) receptors in the developing mouse skeletal muscle and after injury and repair.

MET P2RY13

4.94e-05754221413988
Pubmed

Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.

RGPD2 RGPD8

4.94e-0575428603673
Pubmed

Retina-specifically expressed novel subtypes of bovine cyclophilin.

RGPD2 RGPD8

4.94e-0575427559465
Pubmed

Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).

RGPD2 RGPD8

4.94e-05754226632511
Pubmed

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.

RGPD2 RGPD8

4.94e-05754217372272
Pubmed

Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.

RGPD2 RGPD8

4.94e-05754224403063
Pubmed

Classification and evolutionary analysis of the basic helix-loop-helix gene family in the green anole lizard, Anolis carolinensis.

MLXIPL MLXIP

4.94e-05754223756994
Pubmed

Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.

RGPD2 RGPD8

4.94e-05754223818861
Pubmed

Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.

RGPD2 RGPD8

4.94e-05754238657106
Pubmed

Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.

RGPD2 RGPD8

4.94e-05754211353387
Pubmed

Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.

RGPD2 RGPD8

4.94e-05754212191015
Pubmed

Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

RGPD2 RGPD8

4.94e-05754222821000
Pubmed

Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.

RGPD2 RGPD8

4.94e-05754220682751
Pubmed

The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.

RGPD2 RGPD8

6.59e-05854222262462
Pubmed

The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.

RGPD2 RGPD8

6.59e-05854221670213
Pubmed

Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.

RGPD2 RGPD8

6.59e-05854228745977
Pubmed

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.

RGPD2 RGPD8

6.59e-05854227412403
Pubmed

Mice lacking Ran binding protein 1 are viable and show male infertility.

RGPD2 RGPD8

6.59e-05854221310149
Pubmed

The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.

RGPD2 RGPD8

8.46e-0595429733766
Pubmed

Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.

RGPD2 RGPD8

8.46e-05954228100513
Pubmed

Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.

RGPD2 RGPD8

8.46e-05954218394993
Pubmed

Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.

RGPD2 RGPD8

8.46e-05954228877029
Pubmed

The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.

RGPD2 RGPD8

8.46e-05954211553612
Pubmed

Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.

RGPD2 RGPD8

8.46e-05954217887960
Pubmed

The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.

RGPD2 RGPD8

8.46e-05954210601307
Pubmed

The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.

RGPD2 RGPD8

1.06e-041054227160050
Pubmed

Parkin ubiquitinates and promotes the degradation of RanBP2.

RGPD2 RGPD8

1.06e-041054216332688
Pubmed

Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.

RGPD2 RGPD8

1.06e-04105428857542
Pubmed

Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.

RGPD2 RGPD8

1.06e-041054221859863
Pubmed

An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.

RGPD2 RGPD8

1.29e-041154235771867
Pubmed

RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.

RGPD2 RGPD8

1.29e-041154217069463
Pubmed

T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.

RGPD2 RGPD8

1.29e-041154234110283
Pubmed

Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.

RGPD2 RGPD8

1.83e-041354231427429
Pubmed

Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.

RGPD2 RGPD8

2.45e-041554214697343
Pubmed

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.

RGPD2 RGPD8 ARFGEF1 RGPD5

3.53e-0421554435973513
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

FNBP1 RAPGEF5 RRP12 MLXIP AQR

4.23e-0440754512693553
Pubmed

Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

FNBP1 RGPD2 RGPD8 BCAS1

4.62e-0423154416452087
Pubmed

Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.

RGPD2 RGPD8

5.36e-042254227717094
Pubmed

Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.

TAS2R43 TAS2R46

8.72e-042854215744053
Cytoband12p13.2

TAS2R31 TAS2R43 TAS2R46

1.99e-054553312p13.2
Cytoband2q13

RGPD8 RGPD5

2.84e-03685322q13
GeneFamilyTaste 2 receptors

TAS2R33 TAS2R31 TAS2R43 TAS2R46

1.04e-06393641162
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

RGPD2 RGPD8 UTY RGPD5

7.82e-05115364769
Diseaseserum gamma-glutamyl transferase measurement

MET MLXIPL RAPGEF5 ITGA1 USP3 PIWIL3 KLB

7.39e-04914497EFO_0004532
Diseasecups of coffee per day measurement

MLXIPL CYP11A1

2.02e-0340492EFO_0006782
Diseaseuric acid measurement

MLXIPL NAALAD2 BCAS1 MLXIP KLB

3.35e-03610495EFO_0004761
Diseasetriacylglycerol 52:2 measurement

MLXIPL PTPRO

3.79e-0355492EFO_0010414
Diseaseprotein-glutamine gamma-glutamyltransferase e measurement

MLXIPL ITGA1

4.50e-0360492EFO_0020690
Diseaseoral squamous cell carcinoma (is_marker_for)

MET ATP6V1C1

4.95e-0363492DOID:0050866 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
LWKAGFKGKSKPNLL

ARFGEF1

1706

Q9Y6D6
ELKKTPKLRKFWNLI

AQR

186

O60306
YWKKVLPLLKIIKKN

RGPD5

606

Q99666
YWKKVLPLLKIIKKN

RGPD8

606

O14715
IPGLKWLNKEKKIFQ

IRF2

21

P14316
KDWKISKNLKLVPLQ

LRRC69

311

Q6ZNQ3
GPKCNKLNSKFWKRL

IL1RAPL1

541

Q9NZN1
SVGAKQKKWKPLEFL

GPR153

31

Q6NV75
KSAQKLKPVLEKWLN

POU6F1

196

Q14863
KGKLSTIGKIFKPWK

PHACTR2

31

O75167
LWLKRGLKFLKGFLT

PLEKHA8

406

Q96JA3
KSTWKKKVKSLPNIL

NOL10

466

Q9BSC4
LALWKIGFFKRPLKK

ITGA1

1161

P56199
KKKPVINLKSNALWD

KIZ

631

Q2M2Z5
INPWSKNGLKKRKLT

PTPRO

901

Q16827
VKKCASLKGPLGLKW

P2RY13

191

Q9BPV8
LVSPKWKNFKGLKLQ

MLXIP

141

Q9HAP2
LPLIWKKKCLVQATK

CCN6

201

O95389
ASIVLKFKPDKWSKL

DNAH17

16

Q9UFH2
KSKGKLWPFIKKNKL

FNBP1

316

Q96RU3
PNLKKLWLGKAVEDK

FAM120C

721

Q9NX05
PIGVLLKKSAAWKKD

CYP11A1

136

P05108
EGQGTPKLKLKWKCK

DNAJC17

166

Q9NVM6
KKKKLFAPWRGLQEL

IQCB1

436

Q15051
WKAKNLQHIPLKKGK

KLB

1026

Q86Z14
LPLGKLFWKKSVKED

BCAS1

371

O75363
VKKQPLLVSQGRWKK

PIWIL3

371

Q7Z3Z3
LLLLGFFLWLKKRKQ

MET

946

P08581
FFLWLKKRKQIKDLG

MET

951

P08581
PFILIWGNKKLKQTF

TAS2R31

276

P59538
PFILIWGNKKLKQTF

TAS2R33

276

P0DSN6
PFILIWGNKKLKQTF

TAS2R43

276

P59537
PFILIWGNKKLKQTF

TAS2R46

276

P59540
KKWKLQLHELTKLPA

UTY

1041

O14607
DKKKQFGPLVRWLKV

ATP6V1C1

271

P21283
WKKVLPLLKIIKKNS

RGPD2

606

P0DJD1
LAPLKGFWQKKKKQR

NEXMIF

581

Q5QGS0
LSQTWEKIPGKFKKL

RAPGEF5

451

Q92565
LKLKDKWLGVWKTNP

SHCBP1L

151

Q9BZQ2
PNLLGSKWFIKILKR

RMND1

111

Q9NWS8
KWKRVLPSLLKKSQA

SPATA31E1

576

Q6ZUB1
AKSLIKSWKKLLDGP

TCEA1

66

P23193
FWKSHLKKVQKPLLQ

RHOBTB1

216

O94844
LVSPKWKNFKGLKLL

MLXIPL

101

Q9NP71
KLPSGVSAKLKRWKK

RRP12

6

Q5JTH9
WKNLCLPKEKFKALL

ROPN1L

101

Q96C74
SWKKKAPNKALASVL

SHC2

196

P98077
LETLLKAKWLTPKKN

ZNF558

116

Q96NG5
KLSKRLKKVWKPQLF

MRPL28

96

Q13084
LWNILKPLISHKFGK

ARHGAP8

151

P85298
KKFWIQKLPKVLCLH

USP3

396

Q9Y6I4
LLWKPGAIEKTFTKK

WDR89

346

Q96FK6
WLVVQKGNLKKKPKG

XRRA1

36

Q6P2D8
LLAKKIQTQWKKFGL

NAALAD2

81

Q9Y3Q0
PEWAALAKKQLKGKN

MMUT

41

P22033