Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	inward rectifier potassium channel activity	KCNJ2 KCNJ12 KCNJ18	7.24e-05	28	58	3	GO:0005242
GeneOntologyBiologicalProcess	cardiac muscle thin filament assembly	NRAP NEB	2.33e-05	3	58	2	GO:0071691
GeneOntologyCellularComponent	Z disc	NRAP KRT19 PPP1R12A FBP2 NEB	6.19e-05	151	58	5	GO:0030018
GeneOntologyCellularComponent	I band	NRAP KRT19 PPP1R12A FBP2 NEB	9.70e-05	166	58	5	GO:0031674
GeneOntologyCellularComponent	contractile muscle fiber	NRAP KRT19 PPP1R12A CST1 FBP2 NEB	1.50e-04	290	58	6	GO:0043292
GeneOntologyCellularComponent	sarcomere	NRAP KRT19 PPP1R12A FBP2 NEB	6.31e-04	249	58	5	GO:0030017
Domain	K_chnl_inward-rec_Kir_N	KCNJ2 KCNJ12 KCNJ18	2.84e-08	3	58	3	IPR013673
Domain	IRK_N	KCNJ2 KCNJ12 KCNJ18	2.84e-08	3	58	3	PF08466
Domain	K_chnl_inward-rec_Kir2.2	KCNJ12 KCNJ18	9.48e-06	2	58	2	IPR003272
Domain	K_chnl_inward-rec_Kir_cyto	KCNJ2 KCNJ12 KCNJ18	1.55e-05	16	58	3	IPR013518
Domain	IRK	KCNJ2 KCNJ12 KCNJ18	1.55e-05	16	58	3	PF01007
Domain	-	KCNJ2 KCNJ12 KCNJ18	1.55e-05	16	58	3	2.60.40.1400
Domain	K_chnl_inward-rec_Kir	KCNJ2 KCNJ12 KCNJ18	1.55e-05	16	58	3	IPR016449
Domain	NEBU	NRAP NEB	5.66e-05	4	58	2	SM00227
Domain	Nebulin	NRAP NEB	5.66e-05	4	58	2	PF00880
Domain	Nebulin	NRAP NEB	5.66e-05	4	58	2	IPR013998
Domain	NEBULIN	NRAP NEB	5.66e-05	4	58	2	PS51216
Domain	Nebulin_repeat	NRAP NEB	5.66e-05	4	58	2	IPR000900
Domain	Interfer-bind	IL22RA2 IL20RA	4.20e-04	10	58	2	PF09294
Domain	Interferon/interleukin_rcp_dom	IL22RA2 IL20RA	4.20e-04	10	58	2	IPR015373
Domain	Tissue_fac	IL22RA2 IL20RA	6.13e-04	12	58	2	PF01108
Domain	Tissue_factor	IL22RA2 IL20RA	6.13e-04	12	58	2	IPR001187
Domain	ATPase_dyneun-rel_AAA	MDN1 DNAH8	8.42e-04	14	58	2	IPR011704
Domain	AAA_5	MDN1 DNAH8	8.42e-04	14	58	2	PF07728
Domain	-	NLRP12 MDN1 MPP4 SEPTIN14 DDX18 CHD1 AK9 DNAH8	2.04e-03	746	58	8	3.40.50.300
Domain	Pept_cys_AS	CTSC DNAH8	3.40e-03	28	58	2	IPR000169
Domain	Ig_E-set	KCNJ2 KCNJ12 KCNJ18	4.14e-03	104	58	3	IPR014756
Domain	P-loop_NTPase	NLRP12 MDN1 MPP4 SEPTIN14 DDX18 CHD1 AK9 DNAH8	4.48e-03	848	58	8	IPR027417
Pathway	REACTOME_PHASE_4_RESTING_MEMBRANE_POTENTIAL	KCNJ2 KCNJ12 KCNJ18	3.46e-05	19	48	3	MM15194
Pubmed	Low-affinity spermine block mediating outward currents through Kir2.1 and Kir2.2 inward rectifier potassium channels.	KCNJ2 KCNJ12 KCNJ18	4.40e-09	3	58	3	17640933
Pubmed	The consequences of disrupting cardiac inwardly rectifying K(+) current (I(K1)) as revealed by the targeted deletion of the murine Kir2.1 and Kir2.2 genes.	KCNJ2 KCNJ12 KCNJ18	4.40e-09	3	58	3	11410627
Pubmed	Targeted disruption of Kir2.1 and Kir2.2 genes reveals the essential role of the inwardly rectifying K(+) current in K(+)-mediated vasodilation.	KCNJ2 KCNJ12 KCNJ18	4.40e-09	3	58	3	10904001
Pubmed	Functional characterization of inward rectifier potassium ion channel in murine fetal ventricular cardiomyocytes.	KCNJ2 KCNJ12 KCNJ18	1.76e-08	4	58	3	20798526
Pubmed	The inward rectifier potassium channel family.	KCNJ2 KCNJ12 KCNJ18	8.77e-08	6	58	3	7580148
Pubmed	Functional consequences of Kir2.1/Kir2.2 subunit heteromerization.	KCNJ2 KCNJ12	2.73e-06	2	58	2	20676672
Pubmed	Direct and specific activation of human inward rectifier K+ channels by membrane phosphatidylinositol 4,5-bisphosphate.	KCNJ2 KCNJ12	2.73e-06	2	58	2	20921230
Pubmed	Dual-mode phospholipid regulation of human inward rectifying potassium channels.	KCNJ2 KCNJ12	2.73e-06	2	58	2	21281576
Pubmed	Plasticity of KIR channels in human smooth muscle cells from internal thoracic artery.	KCNJ2 KCNJ12	2.73e-06	2	58	2	12598232
Pubmed	Further association analysis of chr 6q22-24 suggests a role of IL-20RA polymorphisms in psoriasis.	IL22RA2 IL20RA	2.73e-06	2	58	2	19926456
Pubmed	Role of Kir2.2 in hypercapnic ventilatory response during postnatal development of mouse.	KCNJ12 KCNJ18	2.73e-06	2	58	2	15705530
Pubmed	Structural Basis for Differences in Dynamics Induced by Leu Versus Ile Residues in the CD Loop of Kir Channels.	KCNJ2 KCNJ12	2.73e-06	2	58	2	26520451
Pubmed	The clinical and genetic features in a cohort of mainland Chinese patients with thyrotoxic periodic paralysis.	KCNJ2 KCNJ18	2.73e-06	2	58	2	25885757
Pubmed	PITX2 insufficiency leads to atrial electrical and structural remodeling linked to arrhythmogenesis.	KCNJ2 KCNJ12 KCNJ18	3.53e-06	18	58	3	21511879
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	WDR19 NEO1 OXA1L MDN1 SUPT6H SLC20A1 DDX18 PIK3R3 ASNS CHD1 ADI1 PIBF1	5.13e-06	1487	58	12	33957083
Pubmed	Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.	IQGAP2 PPP1R12A ZFHX3 ERLIN1	6.22e-06	71	58	4	23400010
Pubmed	Regulation of cardiac inwardly rectifying potassium current IK1 and Kir2.x channels by endothelin-1.	KCNJ2 KCNJ12	8.19e-06	3	58	2	16258766
Pubmed	Nav1.5 N-terminal domain binding to α1-syntrophin increases membrane density of human Kir2.1, Kir2.2 and Nav1.5 channels.	KCNJ2 KCNJ12	8.19e-06	3	58	2	26786162
Pubmed	Differential polyamine sensitivity in inwardly rectifying Kir2 potassium channels.	KCNJ2 KCNJ12	8.19e-06	3	58	2	16373386
Pubmed	Disruption of the ERLIN-TM6SF2-APOB complex destabilizes APOB and contributes to non-alcoholic fatty liver disease.	APOB ERLIN1	8.19e-06	3	58	2	32776921
Pubmed	Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome.	KCNJ2 KCNJ12	8.19e-06	3	58	2	12032359
Pubmed	Molecular cloning and functional expression of cDNA encoding a second class of inward rectifier potassium channels in the mouse brain.	KCNJ12 KCNJ18	8.19e-06	3	58	2	8083233
Pubmed	Assignment of the murine inward rectifier potassium channel Irk2 (Kir2.2) gene to the central region of mouse chromosome 11.	KCNJ12 KCNJ18	1.64e-05	4	58	2	8921409
Pubmed	A Soluble Epoxide Hydrolase Inhibitor Upregulated KCNJ12 and KCNIP2 by Downregulating MicroRNA-29 in a Mouse Model of Myocardial Infarction.	KCNJ12 KCNJ18	1.64e-05	4	58	2	32990585
Pubmed	Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2.	KCNJ2 KCNJ12	1.64e-05	4	58	2	15958527
Pubmed	Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria.	KCNJ2 KCNJ12 KCNJ18	1.91e-05	31	58	3	17473172
Pubmed	Loss-of-Function Variants in PPP1R12A: From Isolated Sex Reversal to Holoprosencephaly Spectrum and Urogenital Malformations.	PPP1R12A CHD1	2.72e-05	5	58	2	31883643
Pubmed	Dendritic excitability of mouse frontal cortex pyramidal neurons is shaped by the interaction among HCN, Kir2, and Kleak channels.	KCNJ12 KCNJ18	2.72e-05	5	58	2	16177047
Pubmed	Kir2.1 Interactome Mapping Uncovers PKP4 as a Modulator of the Kir2.1-Regulated Inward Rectifier Potassium Currents.	KCNJ2 KCNJ18	2.72e-05	5	58	2	32541000
Pubmed	Inward Rectifier Potassium Channels (Kir2.x) and Caveolin-3 Domain-Specific Interaction: Implications for Purkinje Cell-Dependent Ventricular Arrhythmias.	KCNJ2 KCNJ12	2.72e-05	5	58	2	29326130
Pubmed	Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97.	KCNJ2 KCNJ12	2.72e-05	5	58	2	11181181
Pubmed	Genetic mapping refines DFNB3 to 17p11.2, suggests multiple alleles of DFNB3, and supports homology to the mouse model shaker-2.	KCNJ12 KCNJ18	4.08e-05	6	58	2	9529344
Pubmed	Dysregulation of NRAP degradation by KLHL41 contributes to pathophysiology in nemaline myopathy.	NRAP NEB	4.08e-05	6	58	2	30986853
Pubmed	Gamma motor neurons survive and exacerbate alpha motor neuron degeneration in ALS.	KCNJ12 KCNJ18	7.60e-05	8	58	2	27930290
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	NR2C1 DTWD1 MDN1 CSTF3 KAT2A TOPORS	1.08e-04	453	58	6	29656893
Pubmed	A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels.	KCNJ12 KCNJ18	1.22e-04	10	58	2	14960569
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	MDN1 IQGAP2 KRT19 PPP1R12A APOB RIMS1 KAT2A NEB DNAH8 ERLIN1	1.24e-04	1442	58	10	35575683
Pubmed	Salivary protein profiles are linked to bitter taste acceptance in infants.	CST1 CA6	1.49e-04	11	58	2	24248522
Pubmed	A physical map of the mouse shaker-2 region contains many of the genes commonly deleted in Smith-Magenis syndrome (del17p11.2p11.2).	KCNJ12 KCNJ18	2.11e-04	13	58	2	10049592
Pubmed	Intestinal maturation in mice lacking CCAAT/enhancer-binding protein alpha (C/EPBalpha).	APOB LCT	2.11e-04	13	58	2	9494081
Pubmed	SIRT1 regulates cardiomyocyte alignment during maturation.	PIK3R3 PLCB1	2.11e-04	13	58	2	35260907
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	MDN1 SUPT6H DDX18 ASNS ARIH2 CSTF3 CHD1 KAT2A	2.68e-04	1014	58	8	32416067
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	OXA1L CCDC73 PLCB1 DNAH8	2.74e-04	187	58	4	26460568
Pubmed	International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels.	KCNJ2 KCNJ12	2.83e-04	15	58	2	16382105
Pubmed	Molecular variation at functional genes and the history of human populations--data on candidate genes for cardiovascular risk in the Mediterranean.	PLAT APOB	2.83e-04	15	58	2	14746139
Pubmed	KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy.	NRAP NEB	3.23e-04	16	58	2	24960163
Pubmed	Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins.	KCNJ2 KCNJ12	4.59e-04	19	58	2	15024025
Pubmed	Hypoxia-Regulated lncRNA USP2-AS1 Drives Head and Neck Squamous Cell Carcinoma Progression.	CTSC ARIH2	4.59e-04	19	58	2	36359803
Pubmed	Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved.	IQGAP2 ASNS ARIH2 ERLIN1	4.80e-04	217	58	4	30619736
Pubmed	MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination.	NRAP NEB	5.09e-04	20	58	2	15967462
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	MDN1 SUPT6H DDX18 CHD1	5.23e-04	222	58	4	37071664
Pubmed	Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons.	ASNS APOB	6.18e-04	22	58	2	17983586
Pubmed	Rare independent mutations in renal salt handling genes contribute to blood pressure variation.	KCNJ2 KCNJ12	6.18e-04	22	58	2	18391953
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	MDN1 PPP1R12A NEB UTY	6.37e-04	234	58	4	36243803
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	WDR19 MDN1 PLCB1 COLGALT2 NEB UTY	6.71e-04	638	58	6	31182584
Pubmed	Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor.	KRT19 CHD1	6.76e-04	23	58	2	19841136
Pubmed	A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.	PCGF1 KRT19 SLC20A1 PLCB1 KAT2A	7.63e-04	431	58	5	33660365
Pubmed	Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins.	KCNJ2 KCNJ12	8.00e-04	25	58	2	17185339
Pubmed	SSRI treatment modifies the effects of maternal inflammation on in utero physiology and offspring neurobiology.	CHD1 UTY	8.00e-04	25	58	2	36343752
Pubmed	Localization of somatostatin receptor genes on mouse chromosomes 2, 11, 12, 15, and 17: correlation with growth QTLs.	KCNJ2 CST1	8.66e-04	26	58	2	9226367
Pubmed	Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.	PLCB1 DNAH8	9.34e-04	27	58	2	18649358
Pubmed	Penetrance of craniofacial anomalies in mouse models of Smith-Magenis syndrome is modified by genomic sequence surrounding Rai1: not all null alleles are alike.	KCNJ12 KCNJ18	9.34e-04	27	58	2	17273973
Pubmed	Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.	NEB ERLIN1	9.34e-04	27	58	2	18468998
Pubmed	Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer.	PPP1R12A DDX18	1.00e-03	28	58	2	20689807
Pubmed	Identification of ventricular-side-enriched molecules regulated in a stage-dependent manner during cerebral cortical development.	CKS1B CST1	1.15e-03	30	58	2	16420439
Pubmed	An inter-species protein-protein interaction network across vast evolutionary distance.	MLX KRT19 ARIH2 ZFHX3 ERLIN1	1.27e-03	483	58	5	27107014
Pubmed	Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages.	SUPT6H ZNF267	1.31e-03	32	58	2	26142281
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	MDN1 ARIH2 RMC1	1.33e-03	129	58	3	23022380
Pubmed	Genetic mapping of the human and mouse phospholipase C genes.	PLCB1 PLAT	1.40e-03	33	58	2	8672127
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	ZDHHC15 OXA1L CHD1 APOB ERLIN1	1.42e-03	496	58	5	31343991
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	NEO1 NRAP MLX SUPT6H NEB	1.44e-03	497	58	5	23414517
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	MDN1 SUPT6H SLC20A1 DDX18 CSTF3 CHD1 ERLIN1	1.53e-03	1024	58	7	24711643
GeneFamily	Potassium voltage-gated channel subfamily J	KCNJ2 KCNJ12 KCNJ18	6.39e-06	16	42	3	276
CoexpressionAtlas	parathyroid gland	SGSM1 IQGAP2 KCNJ2 KCNJ12 PLCB1 ZFHX3 PLAT TMC3	4.41e-06	347	58	8	parathyroid gland
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT19 CTSC CST1 ADI1 SLC51A	5.39e-06	194	58	5	40251e6415a62fa55d86f2e8609bf0402e1c1abb
ToppCell	COVID-19-kidney-Epithelial_(EC)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SEPTIN14 PLCB1 PLAT KCNJ18	2.74e-05	133	58	4	a8abb6b54862123961ae6defbf251ee6e9575258
ToppCell	3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT19 CTSC CST1 SLC51A	6.05e-05	163	58	4	22fa5d017ff796394394d952ec151e2d1beb8248
ToppCell	C_02\|World / shred on cell type and cluster	KRT19 SLC20A1 APOB SLC51A	6.34e-05	165	58	4	a456c2c9ffe8dc91e17cac84ba87b88e016f8e6d
ToppCell	356C-Fibroblasts-Fibroblast-H-\|356C / Donor, Lineage, Cell class and subclass (all cells)	MPP4 KCNJ12 PLAT FBP2	6.80e-05	168	58	4	b5d74500bdac0d680ce7eb7afa0b867b8d85e6a4
ToppCell	356C-Fibroblasts-Fibroblast-H\|356C / Donor, Lineage, Cell class and subclass (all cells)	MPP4 KCNJ12 PLAT FBP2	6.80e-05	168	58	4	838ce47d4958ba12047882f97925eddd02f081c7
ToppCell	Adult-Endothelial-endothelial_cell_of_bronchial_vessel\|Adult / Lineage, Cell type, age group and donor	MPP4 PIK3R3 PLCB1 PLAT	7.45e-05	172	58	4	ad4ffdb3fc0c560a9cbaa2bc048476cbc43e8fd6
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NRAP KRT19 CST1 RIMS1	7.79e-05	174	58	4	42f2ba54b4ea4c62482582b0ccdadffae0a5eb4a
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NRAP KRT19 CST1 RIMS1	7.79e-05	174	58	4	3f0a5ce074675d57d479fa069385a1b3071e884e
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-skeletal_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRAP KCNJ12 FBP2 NEB	8.51e-05	178	58	4	69f68eeab11b088fcb1f963c92eff0f1cd0e711a
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-4_VIP_DSEL\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	IQGAP2 KCNJ2 IL20RA PLAT	9.07e-05	181	58	4	70eff83dd85691e977972c660731394d2fcf5cdf
ToppCell	droplet-Marrow-nan-3m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IQGAP2 CTSC PLCB1 ERLIN1	9.27e-05	182	58	4	bc8d621be57f76d718d9b0f11e023b0f4dcb668d
ToppCell	3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT19 CTSC CST1 SLC51A	9.67e-05	184	58	4	c2ca984551baf4becbefbe58bd1889828542b045
ToppCell	NS-critical-LOC-Epithelial-Basal\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	KRT19 PIK3R3 CSTF3 RIMS1	1.01e-04	186	58	4	c28f62524637c7eb9c43c9ec38fb12dfec6f5566
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	IQGAP2 KCNJ2 IL20RA PLAT	1.05e-04	188	58	4	c66fccdfe68760b8c3efca77e3c25966dc9a8a5f
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	NEO1 IQGAP2 PLAT COLGALT2	1.12e-04	191	58	4	156b467187331ac6ca390d6ca861d9670bb7b956
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	SLC20A1 CTSC PLCB1 COLGALT2	1.14e-04	192	58	4	60b1312e84f6d6448365a952469c506c00b5fe93
ToppCell	cellseq-Epithelial-Epithelial_Glandular-Goblet\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KRT19 CST1 RIMS1 SLC51A	1.16e-04	193	58	4	71bf8fb5314b79cb30f4eb9c8459b21f10cd6d35
ToppCell	cellseq-Epithelial-Epithelial_Glandular-Goblet-Goblet\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KRT19 CST1 RIMS1 SLC51A	1.16e-04	193	58	4	b05e110b13d35d34294357c8e1c4fd23bf4b6c92
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM1_(8)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	KCNJ2 CTSC ZFHX3 RIMS1	1.16e-04	193	58	4	e2b455387d1de7812305200a2041a0f4759a6f54
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)-Goblet_(bronchial)_L.0.4.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT19 CST1 RIMS1 SLC51A	1.23e-04	196	58	4	2c3fbfbb08cd327cd97b3fa5a6f83b6d50771fb7
ToppCell	saliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-ciliated_cell\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	KRT19 PIK3R3 IL20RA RIMS1	1.23e-04	196	58	4	d9426eba69047166ffa8179f1654e011c1020328
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT19 CTSC CST1 RIMS1	1.23e-04	196	58	4	8e909c31733762646359fe78b645cbd60237459e
ToppCell	saliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-ciliated_cell-Epi-Ciliated\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	KRT19 PIK3R3 IL20RA RIMS1	1.23e-04	196	58	4	7e19919eafd6ddf547dd4e8aa532a050e182c5cc
ToppCell	critical-Epithelial-Secretory\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CTSC PIK3R3 RIMS1 ADI1	1.23e-04	196	58	4	dbf14f5851c2b779a8b35e820c4584ea9096e49d
ToppCell	suprabasal_cell\|World / shred by cell class for bronchial biopsy	KRT19 CTSC PLAT ADI1	1.23e-04	196	58	4	3c1fa7ec1c7e02b45b2c5843d2c5b2063cd13be8
ToppCell	COVID-19-Epithelial-Club,_Basal_cells\|Epithelial / Condition, Lineage and Cell class	KRT19 CTSC PIK3R3 RIMS1	1.26e-04	197	58	4	78ed2810e5a765327e7a6da0ca5d4854bf7a0b6f
ToppCell	Enterocyte\|World / shred on cell type and cluster	KRT19 SLC20A1 APOB SLC51A	1.26e-04	197	58	4	1dd980fd066aef21694395a4b69df938501d9631
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-mature_enterocytic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KRT19 APOB SLC51A LCT	1.28e-04	198	58	4	686d973483d027a3ffa2ad4430ba6e50f3d1378e
ToppCell	IPF-Endothelial-VE_Peribronchial\|Endothelial / Disease state, Lineage and Cell class	MDN1 ZNF267 PLCB1 CHD1	1.28e-04	198	58	4	b8bd1ba268480f54451648e01631b615a3401144
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KRT19 APOB SLC51A LCT	1.28e-04	198	58	4	a76366611f3561fc8aca7d62d1f0a0ea2bef7792
ToppCell	control-Epithelial-Secretory\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CTSC PIK3R3 RIMS1 ADI1	1.31e-04	199	58	4	3d01f90ffd271ca00129192787e4921bdca7e01e
ToppCell	control-Epithelial-Secretory\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CTSC PIK3R3 RIMS1 ADI1	1.31e-04	199	58	4	262e5b8a52c8ddb0b47048c786e8bdb7158e1b9a
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_2-SERPINF1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	IQGAP2 KCNJ2 IL20RA PLAT	1.33e-04	200	58	4	c4e08cf539c12bb7c61be6d44b4f074bb460f526
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	IQGAP2 KCNJ2 IL20RA PLAT	1.33e-04	200	58	4	913487e065dd580c9cbcbb3c3fc76a8d446f8856
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_2-SERPINF1-L2-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	IQGAP2 KCNJ2 IL20RA PLAT	1.33e-04	200	58	4	f922f9f223cbfed71b8e3115b16b51dc4d7b66b8
Computational	Neighborhood of PHB	PCGF1 DDX18 ARIH2 CSTF3 KAT2A	7.24e-05	125	38	5	MORF_PHB
Disease	protein-tyrosine kinase 2-beta measurement	NLRP12 APOB	2.12e-05	4	56	2	EFO_0801969
Disease	probable ATP-dependent RNA helicase DDX58 measurement	NLRP12 TOPORS	2.12e-05	4	56	2	EFO_0801913
Disease	fructose-1,6-bisphosphatase 1 measurement	NLRP12 FBP2	5.28e-05	6	56	2	EFO_0801606
Disease	trimethyllysine measurement	IL22RA2 IL20RA	1.92e-04	11	56	2	EFO_0009134
Disease	schizophrenia (implicated_via_orthology)	CTSC PLCB1 RIMS1	2.97e-04	68	56	3	DOID:5419 (implicated_via_orthology)
Disease	amenorrhea, response to antineoplastic agent	APOB RIMS1	3.66e-04	15	56	2	EFO_0010269, GO_0097327
Disease	phosphatidylinositol measurement	SUPT6H PLCB1 APOB	7.92e-04	95	56	3	EFO_0010230
Disease	low density lipoprotein cholesterol measurement, response to escitalopram, response to citalopram	ZFHX3 RIMS1	9.51e-04	24	56	2	EFO_0004611, EFO_0006329, EFO_0007871
Disease	Ciliopathies	WDR19 TOPORS DNAH8	1.21e-03	110	56	3	C4277690

Protein segments in the cluster

Peptide	Gene	Start	Entry
KTKEGYYYRQVFERH	ASNS	511	P08243
DAEYYAAHKYATSNK	ERLIN1	261	O75477
KTHGSEYYECSRYKE	ARIH2	331	O95376
EIHIVHYNSKYKSYD	CA6	136	P23280
HYNSKYKSYDIAQDA	CA6	141	P23280
YKQDSRYYSDREKHR	CHD1	1591	O14646
EKAYVEFQDYITKTY	NR2C1	526	P13056
VHKEEDTDTKQVYFY	KAT2A	186	Q92830
FEEKHYYKVDYSRFH	KCNJ2	331	P63252
DYHQEAYKESYKDRR	MLX	116	Q9UH92
FQHKDSYIEYKRADS	OVOS1	1136	Q6IE37
DYSHYYTTIQDLRDK	KRT19	126	P08727
YEDKYYKEVQTVSEH	MDN1	2766	Q9NU22
NQYKIDYSHFHKTYE	KCNJ12	336	Q14500
NVAYKADYKHDIVDY	NRAP	441	Q86VF7
ANDRENYDIIKTYHY	FEM1B	261	Q9UK73
YAKYFDAATTEYVQK	FBP2	216	O00757
YADYEESRMKYEKVH	CSTF3	346	Q12996
YYVAELDATKKLYHS	DNAH8	486	Q96JB1
KKSYEMNGREYHYVS	MPP4	466	Q96JB8
SDAHRKAYEIYHESY	LCT	196	P09848
HARVYHTYDEKYRQE	LCT	1101	P09848
RYQKEKNVSIEDYYE	IL22RA2	186	Q969J5
DHIEYYKASSEMALY	OXA1L	191	Q15070
HKSAQEAYKSYIRAY	DDX18	576	Q9NVP1
TSDYEHQYYAKVKAI	IL20RA	101	Q9UHF4
REQYSKYNIHKDQYR	RIMS1	1316	Q86UR5
YYRRKDHKVGYETFS	SLC51A	316	Q86UW1
SQYQEKSKEYDRLYE	PIK3R3	186	Q92569
FKHLRKYTYNYEAES	APOB	46	P04114
DYHKQLSEIEKYYAT	CCDC73	156	Q6ZRK6
EKYSNRLYKYDHNFV	CTSC	161	P53634
AISEYNKATKDDYYR	CST1	51	P01037
NKHPVAEYKEYYESR	COLGALT2	531	Q8IYK4
YQYHTVHKDSGLYKE	SLC20A1	376	Q8WUM9
YHTDILKEKYRGQYD	DTWD1	261	Q8N5C7
DHSKAHYYRYDEQLN	PCGF1	156	Q9BSM1
NQYKIDYSHFHKTYE	KCNJ18	336	B7U540
TEEAAKYREKIYYFS	AK9	951	Q5TCS8
LYETQRKYHSAKEAY	UTY	211	O14607
RYYVINECDSYKKKH	TMC3	886	Q7Z5M5
LKEKTHTQHYECYRY	SEPTIN14	296	Q6ZU15
HKKYDYYYNTDSKES	IQGAP2	606	Q13576
KYTEYSFRVVAYNKH	NEO1	601	Q92859
HAQTIKVDYKQRYYT	NEO1	781	Q92859
YDDDKVYTYVFHKDT	WDR19	576	Q8NEZ3
MSHKQIYYSDKYDDE	CKS1B	1	P61024
KDVDEAHYAYSFKYL	SUPT6H	626	Q7KZ85
KYIVHKEFDDDTYDN	PLAT	391	P00750
LNHEYKKYLDAEQSY	RMC1	416	Q96DM3
RENSYSYNKYDKDLS	ZNF267	291	Q14586
EEMYEKYVASRDHYK	PIBF1	356	Q8WXW3
KYVASRDHYKTEYEN	PIBF1	361	Q8WXW3
DKIVHYLVENSSKYY	SGSM1	141	Q2NKQ1
QEQYYSEKYQKREHI	PLCB1	1021	Q9NQ66
EHRSYEYHKYGEKSY	ZNF709	126	Q8N972
RKKNNHSERKYYYYE	TOPORS	751	Q9NS56
SQYFEKFDVKESSYH	UHRF1BP1	311	Q6BDS2
KFHLSYTDKERYENE	ZDHHC15	86	Q96MV8
ERFAKQYRDHYDKLY	ZFHX3	2016	Q15911
IYHRFTVDEKNYTKA	ADI1	131	Q9BV57
SEAERKEYFYKYFHN	NLRP12	366	P59046
EDEYKQKYSRTYDET	PPP1R12A	751	O14974
SRDIASDYKYKEAYR	NEB	3271	P20929
ASRDIASDYKYKEAY	NEB	3756	P20929