Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionretinoid binding

UGT1A4 UGT1A3 UGT1A5 RHO

3.72e-0648444GO:0005501
GeneOntologyMolecularFunctionisoprenoid binding

UGT1A4 UGT1A3 UGT1A5 RHO

4.04e-0649444GO:0019840
GeneOntologyMolecularFunctionlow voltage-gated calcium channel activity

CACNA1I CACNA1H

1.42e-053442GO:0008332
GeneOntologyMolecularFunctionretinoic acid binding

UGT1A4 UGT1A3 UGT1A5

3.15e-0528443GO:0001972
GeneOntologyMolecularFunctionglucuronosyltransferase activity

UGT1A4 UGT1A3 UGT1A5

6.22e-0535443GO:0015020
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1I CACNA1H

4.25e-0414442GO:0008331
GeneOntologyBiologicalProcesscellular glucuronidation

UGT1A4 UGT1A3 UGT1A5

1.17e-0521443GO:0052695
GeneOntologyBiologicalProcessglucuronate metabolic process

UGT1A4 UGT1A3 UGT1A5

2.28e-0526443GO:0019585
GeneOntologyBiologicalProcessuronic acid metabolic process

UGT1A4 UGT1A3 UGT1A5

2.28e-0526443GO:0006063
GeneOntologyBiologicalProcessvitamin D3 metabolic process

UGT1A4 UGT1A3

1.59e-049442GO:0070640
GeneOntologyCellularComponentrod photoreceptor outer segment

GUCY2F RHO

1.54e-049442GO:0120200
DomainUDPGT

UGT1A4 UGT1A3 UGT1A5

1.47e-0521433PS00375
DomainUDPGT

UGT1A4 UGT1A3 UGT1A5

1.47e-0521433PF00201
DomainUDP_glucos_trans

UGT1A4 UGT1A3 UGT1A5

1.47e-0521433IPR002213
DomainVDCC_T_a1

CACNA1I CACNA1H

1.55e-053432IPR005445
DomainVDCCAlpha1

CACNA1I CACNA1H

2.30e-0410432IPR002077
DomainChannel_four-helix_dom

CACNA1I CACNA1H

7.63e-0357432IPR027359
Domain-

CACNA1I CACNA1H

7.63e-03574321.20.120.350
PathwayREACTOME_ATORVASTATIN_ADME

UGT1A4 UGT1A3 UGT1A5

6.25e-0615353MM15697
PathwayREACTOME_HEME_DEGRADATION

UGT1A4 UGT1A3 UGT1A5

1.55e-0520353MM14721
PathwayREACTOME_PREDNISONE_ADME

UGT1A4 UGT1A3 UGT1A5

2.40e-0523353MM16639
PathwayREACTOME_GLUCURONIDATION

UGT1A4 UGT1A3 UGT1A5

2.74e-0524353MM14599
PathwayREACTOME_GLUCURONIDATION

UGT1A4 UGT1A3 UGT1A5

3.11e-0525353M17787
PathwayWP_GLUCURONIDATION

UGT1A4 UGT1A3 UGT1A5

3.11e-0525353MM15820
PathwayKEGG_ASCORBATE_AND_ALDARATE_METABOLISM

UGT1A4 UGT1A3 UGT1A5

3.11e-0525353M605
PathwayWP_GLUCURONIDATION

UGT1A4 UGT1A3 UGT1A5

3.51e-0526353M39404
PathwayKEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS

UGT1A4 UGT1A3 UGT1A5

4.40e-0528353M19580
PathwayREACTOME_METABOLISM_OF_PORPHYRINS

UGT1A4 UGT1A3 UGT1A5

6.62e-0532353MM14719
PathwayKEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM

UGT1A4 UGT1A3 UGT1A5

1.40e-0441353M7399
PathwayREACTOME_ASPIRIN_ADME

UGT1A4 UGT1A3 UGT1A5

1.73e-0444353M45014
PathwayREACTOME_ASPIRIN_ADME

UGT1A4 UGT1A3 UGT1A5

1.85e-0445353MM15694
PathwayKEGG_DRUG_METABOLISM_OTHER_ENZYMES

UGT1A4 UGT1A3 UGT1A5

2.69e-0451353M17726
PathwayKEGG_STARCH_AND_SUCROSE_METABOLISM

UGT1A4 UGT1A3 UGT1A5

2.85e-0452353M14171
PathwayKEGG_STEROID_HORMONE_BIOSYNTHESIS

UGT1A4 UGT1A3 UGT1A5

3.37e-0455353M14933
PathwayKEGG_RETINOL_METABOLISM

UGT1A4 UGT1A3 UGT1A5

5.27e-0464353M9488
PathwayKEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450

UGT1A4 UGT1A3 UGT1A5

6.85e-0470353M16794
PathwayKEGG_DRUG_METABOLISM_CYTOCHROME_P450

UGT1A4 UGT1A3 UGT1A5

7.44e-0472353M9257
PathwayWP_ESTROGEN_METABOLISM

UGT1A3 UGT1A5

1.34e-0322352MM15888
PathwayPID_RHODOPSIN_PATHWAY

GUCY2F RHO

1.47e-0323352M204
PathwayKEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1I CACNA1H

1.47e-0323352M47666
PathwayKEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL

CACNA1I CACNA1H

1.73e-0325352M47948
PathwayWP_DISORDERS_OF_BILE_ACID_SYNTHESIS_AND_BILIARY_TRANSPORT

ABCD3 ATP8B1

2.33e-0329352M45551
PathwayREACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS

UGT1A4 UGT1A3 UGT1A5

2.33e-03107353MM14595
PathwayREACTOME_DRUG_ADME

UGT1A4 UGT1A3 UGT1A5

2.46e-03109353M45012
PathwayREACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS

UGT1A4 UGT1A3 UGT1A5

2.46e-03109353M18788
PathwayWP_CONSTITUTIVE_ANDROSTANE_RECEPTOR_PATHWAY

UGT1A4 NCOA6

2.66e-0331352M39476
PathwayREACTOME_THE_PHOTOTRANSDUCTION_CASCADE

GUCY2F RHO

2.66e-0331352MM14896
PathwayREACTOME_DRUG_ADME

UGT1A4 UGT1A3 UGT1A5

3.15e-03119353MM15692
PathwayREACTOME_THE_PHOTOTRANSDUCTION_CASCADE

GUCY2F RHO

3.20e-0334352M27183
Pubmed

A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study.

UGT1A4 UGT1A3 UGT1A5

1.69e-07945322511988
Pubmed

A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini.

UGT1A4 UGT1A3 UGT1A5

1.69e-0794531339448
Pubmed

Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study.

UGT1A4 UGT1A3 UGT1A5

2.41e-071045323642732
Pubmed

UDP-glucuronosyltransferases.

UGT1A4 UGT1A3 UGT1A5

2.41e-071045311465080
Pubmed

A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population.

UGT1A4 UGT1A3 UGT1A5

2.41e-071045323371916
Pubmed

A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia.

UGT1A4 UGT1A3 UGT1A5

2.41e-071045322558097
Pubmed

Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.

UGT1A4 UGT1A3 UGT1A5

4.42e-071245319419973
Pubmed

Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus.

UGT1A4 UGT1A3 UGT1A5

4.42e-071245311434514
Pubmed

UGT1A1 is a major locus influencing bilirubin levels in African Americans.

UGT1A4 UGT1A3 UGT1A5

5.74e-071345322085899
Pubmed

Genome-wide analysis of hepatic lipid content in extreme obesity.

UGT1A4 UGT1A3 UGT1A5

5.74e-071345325246029
Pubmed

Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels.

UGT1A4 UGT1A3 UGT1A5

7.29e-071445321646302
Pubmed

Human UDP-glucuronosyltransferases: metabolism, expression, and disease.

UGT1A4 UGT1A3 UGT1A5

7.29e-071445310836148
Pubmed

Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation.

UGT1A4 UGT1A3 UGT1A5

7.29e-071445314672974
Pubmed

The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.

UGT1A4 UGT1A3 UGT1A5

7.29e-07144539295054
Pubmed

Genome-wide association meta-analysis for total serum bilirubin levels.

UGT1A4 UGT1A3 UGT1A5

1.12e-061645319414484
Pubmed

Genome-wide association of serum bilirubin levels in Korean population.

UGT1A4 UGT1A3 UGT1A5

1.36e-061745320639394
Pubmed

A T-type calcium channel required for normal function of a mammalian mechanoreceptor.

CACNA1I CACNA1H

1.64e-06245212808460
Pubmed

Cloning and characterization of cDNAs encoding mouse Ugt1.6 and rabbit UGT1.6: differential induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

UGT1A3 UGT1A5

1.64e-0624528068691
Pubmed

Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice.

CACNA1I CACNA1H

1.64e-06245225071191
Pubmed

Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: metabolite structure, kinetics, inducibility, and interindividual variability.

UGT1A4 UGT1A3

1.64e-06245224641623
Pubmed

Whole Exome Sequencing of Hemiplegic Migraine Patients Shows an Increased Burden of Missense Variants in CACNA1H and CACNA1I Genes.

CACNA1I CACNA1H

1.64e-06245236786913
Pubmed

N-glucuronidation of nicotine and cotinine by human liver microsomes and heterologously expressed UDP-glucuronosyltransferases.

UGT1A4 UGT1A3

1.64e-06245214570768
Pubmed

A genome-wide assessment of variability in human serum metabolism.

UGT1A4 UGT1A3 UGT1A5

1.93e-061945323281178
Pubmed

Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.

PUM1 AKAP17A ANAPC1 RRP12 SEC24B

3.83e-0618245532239614
Pubmed

Genetic determinants influencing human serum metabolome among African Americans.

UGT1A4 UGT1A3 UGT1A5

4.02e-062445324625756
Pubmed

Ethanol inhibition of a T-type Ca²+ channel through activity of protein kinase C.

CACNA1I CACNA1H

4.91e-06345223488970
Pubmed

T-type channels: release a brake, engage a gear.

CACNA1I CACNA1H

4.91e-06345226488564
Pubmed

Differential interactions of Na+ channel toxins with T-type Ca2+ channels.

CACNA1I CACNA1H

4.91e-06345218591418
Pubmed

Identification of the t-type calcium channel (Ca(v)3.1d) in developing mouse heart.

CACNA1I CACNA1H

4.91e-06345211230107
Pubmed

Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice.

CACNA1I CACNA1H

4.91e-06345211897840
Pubmed

Prognostic relevance of a T-type calcium channels gene signature in solid tumours: A correlation ready for clinical validation.

CACNA1I CACNA1H

4.91e-06345228846697
Pubmed

Homeostatic plasticity and burst activity are mediated by hyperpolarization-activated cation currents and T-type calcium channels in neuronal cultures.

CACNA1I CACNA1H

4.91e-06345233547341
Pubmed

Calmodulin regulates Cav3 T-type channels at their gating brake.

CACNA1I CACNA1H

4.91e-06345228972185
Pubmed

Isolation and characterization of a UDP-glucuronosyltransferase (UGT1A01) cloned from female rhesus monkey.

UGT1A3 UGT1A5

4.91e-06345212051676
Pubmed

Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability.

CACNA1I CACNA1H

4.91e-06345211927664
Pubmed

Human UDP-glucuronosyltransferase (UGT) 2B10 in drug N-glucuronidation: substrate screening and comparison with UGT1A3 and UGT1A4.

UGT1A4 UGT1A3

4.91e-06345223611809
Pubmed

A role for UDP-glucose glycoprotein glucosyltransferase in expression and quality control of MHC class I molecules.

UGT1A3 UGT1A5

4.91e-06345221383159
Pubmed

Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor.

UGT1A3 UGT1A5

9.81e-06445212644700
Pubmed

Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8.

UGT1A4 UGT1A3

9.81e-0644529535849
Pubmed

Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue.

UGT1A4 UGT1A3

9.81e-0644529271343
Pubmed

Genetic variations and haplotypes of UDP-glucuronosyltransferase 1A locus in a Korean population.

UGT1A4 UGT1A5

9.81e-06445218223459
Pubmed

Pharmacogenetics of antiepileptic drug efficacy in childhood absence epilepsy.

CACNA1I CACNA1H

9.81e-06445228165634
Pubmed

Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4.

UGT1A4 UGT1A3

1.63e-05545215057901
Pubmed

Isolation of cDNAs for mouse phenol and bilirubin UDP-glucuronosyltransferases and mapping of the mouse gene for phenol UDP-glucuronosyltransferase (Ugtla1) to chromosome 1 by restriction fragment length variations.

UGT1A3 UGT1A5

1.63e-0554527677729
Pubmed

Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population.

UGT1A4 UGT1A3

2.45e-05645219204906
Pubmed

Three ways to make a vesicle.

TXNDC5 PUM1 SEC24B

2.58e-054445311252894
Pubmed

Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37.

UGT1A4 UGT1A5

3.42e-0574528467709
Pubmed

Molecular cloning of two cDNAs encoding the mouse bilirubin/phenol family of UDP-glucuronosyltransferases (mUGTBr/p).

UGT1A3 UGT1A5

3.42e-0574528464825
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

ABCD3 PRPF19 SMPDL3B TXNDC5 PUM1 POLDIP3 HNRNPH3 RRP12

4.50e-05102445824711643
Pubmed

Simultaneous evaluation of six human glucuronidation activities in liver microsomes using liquid chromatography-tandem mass spectrometry.

UGT1A4 UGT1A3

4.56e-05845222579593
Pubmed

Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.

CACNA1I CACNA1H

4.56e-05845228330839
Pubmed

Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation.

UGT1A4 UGT1A3

4.56e-05845217179145
Pubmed

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro.

UGT1A4 UGT1A3

4.56e-05845220610558
Pubmed

Involvement of human UGT2B7 and 2B15 in rofecoxib metabolism.

UGT1A4 UGT1A3

4.56e-05845212695355
Pubmed

Neuroepithelial progenitors generate and propagate non-neuronal action potentials across the spinal cord.

CACNA1I CACNA1H

4.56e-05845234478646
Pubmed

Intracellular calcium plays an essential role in cardiac development.

CACNA1I CACNA1H

4.56e-05845212761855
Pubmed

Human metabolic individuality in biomedical and pharmaceutical research.

UGT1A4 UGT1A3 UGT1A5

5.64e-055745321886157
Pubmed

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

CACNA1I CACNA1H

5.86e-05945216382099
Pubmed

Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage.

CACNA1I CACNA1H

7.32e-051045224778262
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

MAP3K20 RPF1 PUM1 AKAP17A POLDIP3 HNRNPH3 RRP12

7.43e-0580745722681889
Pubmed

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.

UGT1A4 UGT1A3 UGT1A5

8.75e-056645319898482
Pubmed

Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans.

UGT1A4 UGT1A3

1.07e-041245220308471
Pubmed

Detoxification enzyme polymorphisms are not involved in duodenal adenomatosis in familial adenomatous polyposis.

UGT1A4 UGT1A3

1.07e-041245218161889
Pubmed

Directed proteomic analysis of the human nucleolus.

RPF1 PRPF19 HNRNPH3 RRP12

1.53e-0420845411790298
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

ABCD3 PRPF19 NCOA6 SMPDL3B TXNDC5 POLDIP3 HNRNPH3 SEC24B

1.77e-04124745827684187
Pubmed

Secretory protein trafficking and organelle dynamics in living cells.

TXNDC5 PUM1 SEC24B

1.86e-048545311031247
Pubmed

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.

ABCD3 PRPF19 TXNDC5 PUM1 POLDIP3 RRP12

1.90e-0465545635819319
Pubmed

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.

PRPF19 HECA HNRNPH3 MAN1B1 RRP12

1.99e-0441745536537216
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

MAP3K20 ABCD3 PRPF19 PUM1 POLDIP3 HNRNPH3 RRP12 SEC24B

3.07e-04135345829467282
Pubmed

OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer.

PRPF19 POLDIP3

3.38e-042145230662561
Pubmed

Functional proteomic analysis of human nucleolus.

RPF1 PRPF19 RRP12

3.56e-0410645312429849
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

RPF1 PRPF19 AKAP17A POLDIP3 HNRNPH3 RRP12

4.18e-0475945635915203
Pubmed

Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.

PRPF19 ANAPC1 RGS3 POLDIP3

4.24e-0427245431010829
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

ABCD3 PRPF19 TXNDC5 PUM1 ANAPC1 POLDIP3 HNRNPH3 RRP12

4.34e-04142545830948266
Pubmed

Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.

PRPF19 PUM1 HNRNPH3

4.40e-0411445331553912
Pubmed

Human transcription factor protein interaction networks.

ABCD3 PRPF19 NCOA6 PUM1 POLDIP3 HNRNPH3 RRP12 SEC24B

4.42e-04142945835140242
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

DPYSL5 ABCD3 PRPF19 AKAP17A POLDIP3 HNRNPH3 RRP12

4.47e-04108245738697112
Pubmed

A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.

ABCD3 PRPF19 AKAP17A POLDIP3 HNRNPH3 RRP12

5.02e-0478645629128334
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

DPYSL5 MAP3K20 NCOA6 PUM1 PIK3C2B SEC24B

8.09e-0486145636931259
Pubmed

ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.

ABCD3 PRPF19 HNRNPH3 RRP12

8.73e-0433045433301849
Pubmed

Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport.

ST3GAL2 MAN1B1

1.06e-03374522542563
Pubmed

Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1.

ST3GAL2 MAN1B1

1.06e-03374522541446
Pubmed

Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis.

ST3GAL2 MAN1B1

1.12e-03384522829950
Pubmed

Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1.

ST3GAL2 MAN1B1

1.12e-03384522187500
Pubmed

Ubiquitin-assisted phase separation of dishevelled-2 promotes Wnt signalling.

ABCD3 PRPF19 POLDIP3

1.20e-0316145336398662
Pubmed

A protein-RNA interaction atlas of the ribosome biogenesis factor AATF.

PRPF19 PUM1 RRP12

1.22e-0316245331363146
Pubmed

Exome sequencing supports a de novo mutational paradigm for schizophrenia.

UGT1A3 SLC26A7

1.24e-034045221822266
InteractionKDF1 interactions

PUM1 AKAP17A ANAPC1 RRP12 SEC24B

3.74e-05192405int:KDF1
InteractionUGT1A3 interactions

UGT1A3 UGT1A5

3.83e-055402int:UGT1A3
Cytoband2q37

UGT1A4 UGT1A3 UGT1A5

3.88e-06314532q37
Cytoband11p15.4

OR52E1 OR52H1 OR52E8

1.01e-0320045311p15.4
CytobandEnsembl 112 genes in cytogenetic band chr2q37

UGT1A4 UGT1A3 UGT1A5

1.43e-03226453chr2q37
GeneFamilyUDP glucuronosyltransferases

UGT1A4 UGT1A3 UGT1A5

2.19e-0532313363
GeneFamilyOlfactory receptors, family 52

OR52E1 OR52H1 OR52E8

7.97e-0549313165
GeneFamilyCalcium voltage-gated channel subunits

CACNA1I CACNA1H

9.01e-0426312253
CoexpressionLANDIS_ERBB2_BREAST_TUMORS_65_DN

UGT1A3 HEPH UGT1A5 ADIPOR2

5.52e-0741424MM1093
Drugalmokalant

UGT1A4 UGT1A3 HEPH UGT1A5

4.19e-0819434CID003033962
DrugAC1MRQNQ

UGT1A4 UGT1A3 UGT1A5

5.23e-079433CID003522271
DrugDHPASiU

UGT1A4 UGT1A3 UGT1A5

5.23e-079433CID000197602
DrugChebi:32663

UGT1A4 UGT1A3 UGT1A5

5.23e-079433CID005460873
Drug3-iodophenol

UGT1A4 UGT1A3 UGT1A5

5.23e-079433CID000012272
DrugAC1L4J7U

UGT1A4 UGT1A3 UGT1A5

5.23e-079433CID000186631
Drug4-nitrophenyl)imidazole

UGT1A4 UGT1A3 UGT1A5

1.02e-0611433CID000123155
DrugAC1O5XMV

UGT1A4 UGT1A3 UGT1A5

1.02e-0611433CID006442661
DrugN-OH-DABZ

UGT1A4 UGT1A3 UGT1A5

1.36e-0612433CID000051366
Drug1-O-beta-D-glucopyranosyl-D-mannitol

UGT1A4 UGT1A3 UGT1A5

1.36e-0612433CID000088735
Drug2,4,6-TCB

UGT1A4 UGT1A3 UGT1A5

1.36e-0612433CID000037247
Drug7,7,7-triphenylheptanoic acid

UGT1A4 UGT1A3 UGT1A5

1.36e-0612433CID000276709
Drugnonanoyl-N-methylglucamide

UGT1A4 UGT1A3 UGT1A5

1.36e-0612433CID000160090
DrugMS-222

UGT1A4 UGT1A3 UGT1A5 RHO

1.42e-0644434CID000011400
Drugtritanol

UGT1A4 UGT1A3 UGT1A5

1.77e-0613433CID000006457
Drug5-azido-UDP-glucuronic acid

UGT1A4 UGT1A3 UGT1A5

1.77e-0613433CID003081279
Drugcotinine-N-glucuronide

UGT1A4 UGT1A3 UGT1A5

1.77e-0613433CID000000411
Drugpropranolol glucuronide

UGT1A4 UGT1A3 UGT1A5

2.25e-0614433CID000119515
DrugPCB-61

UGT1A4 UGT1A3 UGT1A5

2.25e-0614433CID000036401
Druglamotrigine

UGT1A4 UGT1A3 CACNA1I CACNA1H UGT1A5

2.60e-06116435CID000003878
Drug2,2',3,5,5'-pentachlorobiphenyl

UGT1A4 UGT1A3 UGT1A5

2.81e-0615433CID000040469
Drugcoumarin-3-carboxylic acid

UGT1A4 UGT1A3 UGT1A5

2.81e-0615433CID000010752
Drugsulforaphane nitrile

UGT1A4 UGT1A3 UGT1A5

2.81e-0615433CID000543743
Drugafloqualone

UGT1A4 UGT1A3 UGT1A5

2.81e-0615433CID000002040
Drugnaphthyl sulphate

UGT1A4 UGT1A3 UGT1A5

2.81e-0615433CID000114775
DrugHCG 004

UGT1A4 UGT1A3 UGT1A5 ADIPOR2

3.26e-0654434CID000064928
Drugquercetin-3,4'-diglucoside

UGT1A4 UGT1A3 UGT1A5

3.45e-0616433CID005320835
Drug1'-hydroxyestragole

UGT1A4 UGT1A3 UGT1A5

3.45e-0616433CID000040003
Drugbilirubin-phosphate

UGT1A4 UGT1A3 UGT1A5

3.45e-0616433CID005497144
Drugafloqualone

UGT1A4 UGT1A3

3.48e-062432ctd:C033541
Drug3 beta,5 alpha,25R)- 3-hydroxyspirostan-12-one

UGT1A4 UGT1A3 UGT1A5

4.19e-0617433CID000003573
Drug6-hydroxychrysene

UGT1A4 UGT1A3 UGT1A5

4.19e-0617433CID000037766
Drugethyl-beta-D-6-glucosiduronic acid

UGT1A4 UGT1A3 UGT1A5

5.02e-0618433CID000152226
DrugBr 2

UGT1A4 UGT1A3 UGT1A5

5.02e-0618433CID003060900
DrugSureCN12722713

UGT1A4 UGT1A3 UGT1A5

5.02e-0618433CID005488034
Drug2,3,7-trichlorodibenzo-p-dioxin

UGT1A4 UGT1A3 UGT1A5

5.02e-0618433CID000036614
DrugApApG

UGT1A4 UGT1A3 UGT1A5

5.02e-0618433CID003081975
DrugC1 11-32

UGT1A4 UGT1A3 UGT1A5

5.02e-0618433CID000443077
DrugC11131

UGT1A4 UGT1A3 UGT1A5

5.02e-0618433CID000443076
Drug9-OH-risperidone

UGT1A4 UGT1A3 UGT1A5

5.95e-0619433CID000475100
Drug5alpha-spirostan-3beta-ol

UGT1A4 UGT1A3 UGT1A5

5.95e-0619433CID000091433
Drugtectochrysin

UGT1A4 UGT1A3 UGT1A5

6.99e-0620433CID005281954
DrugAC1L1OBF

UGT1A4 UGT1A3 UGT1A5

6.99e-0620433CID000032736
Drug4'-hydroxydiclofenac

UGT1A4 UGT1A3 UGT1A5

6.99e-0620433CID000116545
Drugestriol-16-glucuronide

UGT1A4 UGT1A3 UGT1A5

8.15e-0621433CID000122281
Drugdulcin

UGT1A4 UGT1A3 UGT1A5

8.15e-0621433CID000009013
DrugBenzamidoxime hydrochloride

UGT1A4 UGT1A3 UGT1A5

8.15e-0621433CID000069186
Drugamonafide

UGT1A4 UGT1A3 UGT1A5

9.42e-0622433CID000050515
DrugN-methylpiperazine

UGT1A4 UGT1A3 UGT1A5

9.42e-0622433CID000053167
DrugSureCN2398996

CACNA1I CACNA1H

1.04e-053432CID010220069
DrugN-desmethylmethsuximide

CACNA1I CACNA1H

1.04e-053432CID000092154
Drug1,3-dioxoisoindoline-5-carboxamide

CACNA1I CACNA1H

1.04e-053432CID010679219
Drugamidoxime

UGT1A4 UGT1A3 UGT1A5

1.08e-0523433CID000465967
Drugestradiol-3-glucuronide

UGT1A4 UGT1A3 UGT1A5

1.08e-0523433CID000066651
Drugphenanthridine

UGT1A4 UGT1A3 UGT1A5

1.08e-0523433CID000009189
Drug2,2,2-trichloroethanol

UGT1A4 UGT1A3 P2RY4 UGT1A5

1.09e-0573434CID000008259
DrugAS-3201

UGT1A4 UGT1A3 UGT1A5

1.24e-0524433CID000153948
Drug5-MOP

UGT1A4 UGT1A3 UGT1A5

1.40e-0525433CID000002355
DrugAzMC

UGT1A4 UGT1A3 UGT1A5

1.40e-0525433CID000064986
DrugN-acetylbenzidine

UGT1A4 UGT1A3 UGT1A5

1.40e-0525433CID000018787
Drug5,6-benzoquinoline

UGT1A4 UGT1A3 UGT1A5

1.40e-0525433CID000006796
DrugN-phenylmaleimide

UGT1A4 UGT1A3 UGT1A5

1.40e-0525433CID000013662
Drugciprofibrate

UGT1A4 ABCD3 UGT1A3 NCOA6 UGT1A5

1.67e-05170435CID000002763
DrugDiMeIQx

UGT1A4 UGT1A3 UGT1A5

1.78e-0527433CID000104739
Drugdiflunisal

UGT1A4 UGT1A3 UGT1A5

1.78e-0527433CID000003059
Drugphenylbutazone

UGT1A4 UGT1A3 NCOA6 UGT1A5

1.82e-0583434CID000004781
Drug5 alpha-androstane

UGT1A4 UGT1A3 NCOA6 UGT1A5

1.91e-0584434CID000094144
DrugN-hydroxy-4-aminobiphenyl

UGT1A4 UGT1A3 UGT1A5

1.99e-0528433CID000081261
DrugCARMINE

UGT1A4 UGT1A3 UGT1A5

1.99e-0528433CID000014749
Drugerucin

UGT1A4 UGT1A3 UGT1A5

1.99e-0528433CID000078160
DrugH-Ni

UGT1A4 UGT1A3 UGT1A5

1.99e-0528433CID000445665
Drugmethsuximide

CACNA1I CACNA1H

2.09e-054432CID000006476
DrugAC1L1JAL

UGT1A4 UGT1A3 UGT1A5

2.22e-0529433CID000004954
Drug7-hydroxy-4-trifluoromethylcoumarin

UGT1A4 UGT1A3 UGT1A5

2.22e-0529433CID005375667
Drugtrans-3'-hydroxycotinine

UGT1A4 UGT1A3 UGT1A5

2.22e-0529433CID000000414
Drug7-hydroxycoumarin glucuronide

UGT1A4 UGT1A3 UGT1A5

2.22e-0529433CID000125641
Drugiberin

UGT1A4 UGT1A3 UGT1A5

2.22e-0529433CID000010455
Drugtolcapone

UGT1A4 UGT1A3 UGT1A5

2.46e-0530433CID004659569
Drugparicalcitol

UGT1A4 UGT1A3 UGT1A5

2.46e-0530433CID005281104
DrugAC1L9E0Q

UGT1A4 UGT1A3 UGT1A5

2.46e-0530433CID000443095
Drugdihydroartemisinin

UGT1A4 UGT1A3 UGT1A5

2.46e-0530433CID000107770
Drug4-ethylphenol

UGT1A4 UGT1A3 UGT1A5

2.72e-0531433CID000031242
DrugPCB 156

UGT1A4 UGT1A3 UGT1A5

2.72e-0531433CID000038019
Drug4'-HPPH

UGT1A4 UGT1A3 UGT1A5

2.72e-0531433CID000017732
Drugindole-2-carboxylic acid

UGT1A4 UGT1A3 UGT1A5

3.00e-0532433CID000072899
DrugNNAL

UGT1A4 UGT1A3 UGT1A5

3.00e-0532433CID000104856
DrugMuracein C

UGT1A4 UGT1A3 UGT1A5

3.00e-0532433CID003086323
DrugTCPOBOP

UGT1A4 UGT1A3 NCOA6 UGT1A5

3.10e-0595434CID000005382
Drugcox-2 inhibitor I; Up 200; 10uM; MCF7; HG-U133A

CACNA1I CACNA1H ST3GAL2 RRP12 HHIPL2

3.24e-05195435207_UP
DrugAC1Q6OQG

UGT1A4 UGT1A3 UGT1A5

3.29e-0533433CID000009686
DrugR(-)-Denopamine

UGT1A4 UGT1A3 UGT1A5

3.29e-0533433CID000003818
Drug6-methylsalicylic acid

UGT1A4 UGT1A3 UGT1A5

3.29e-0533433CID000011279
DrugBP-3,6-quinol

UGT1A4 UGT1A3 UGT1A5

3.29e-0533433CID000119292
Drugnorbuprenorphine

UGT1A4 UGT1A3 UGT1A5

3.29e-0533433CID000114976
Druggeniposide

UGT1A4 UGT1A3 UGT1A5

3.29e-0533433CID000107848
DrugAC1O7G5C

CACNA1I CACNA1H

3.47e-055432CID006603942
Drugphensuximide

CACNA1I CACNA1H

3.47e-055432CID000006839
DrugFlunarizine

CACNA1I CACNA1H

3.47e-055432DB04841
Drugestragole

UGT1A4 UGT1A3 UGT1A5

3.60e-0534433CID000008815
DrugAcetopromazine maleate salt [3598-37-6]; Up 200; 9uM; MCF7; HT_HG-U133A

CACNA1I SPAG8 RGS3 POLDIP3 RHO

3.65e-052004352769_UP
DiseaseX-11793--oxidized bilirubin measurement

UGT1A4 UGT1A3 UGT1A5

1.29e-078403EFO_0021260
DiseaseSuccinimide measurement

UGT1A4 UGT1A3 UGT1A5

1.29e-078403EFO_0022118
DiseaseX-24849 measurement

UGT1A4 UGT1A3 UGT1A5

1.29e-078403EFO_0800909
DiseaseX-11530 measurement

UGT1A4 UGT1A3 UGT1A5

1.29e-078403EFO_0021249
Diseasesulfate of piperine metabolite C16H19NO3 (2) measurement

UGT1A4 UGT1A3 UGT1A5

1.29e-078403EFO_0801034
Diseasecholelithiasis, bilirubin measurement

UGT1A4 UGT1A3 UGT1A5

1.29e-078403EFO_0004570, EFO_0004799
DiseaseX-11522 measurement

UGT1A4 UGT1A3 UGT1A5

1.29e-078403EFO_0800696
DiseaseX-10458 measurement

UGT1A4 UGT1A3 UGT1A5

1.29e-078403EFO_0800692
Diseasemembrane-associated progesterone receptor component 1 measurement

UGT1A4 UGT1A3 UGT1A5

1.29e-078403EFO_0802740
DiseaseX-16946 measurement

UGT1A4 UGT1A3 UGT1A5

1.29e-078403EFO_0800766
DiseaseX-11442 measurement

UGT1A4 UGT1A3 UGT1A5

1.93e-079403EFO_0021236
DiseaseX-11441 measurement

UGT1A4 UGT1A3 UGT1A5

1.93e-079403EFO_0021235
Diseasecirculating cell free DNA measurement

UGT1A4 UGT1A3 UGT1A5

1.93e-079403EFO_0004739
Diseasesulfate of piperine metabolite C18H21NO3 (3) measurement

UGT1A4 UGT1A3 UGT1A5

1.93e-079403EFO_0801037
Diseasetestis-specific chromodomain protein Y 1 measurement

UGT1A4 UGT1A3 UGT1A5

1.93e-079403EFO_0802127
Diseasesulfate of piperine metabolite C18H21NO3 (1) measurement

UGT1A4 UGT1A3 UGT1A5

1.93e-079403EFO_0801036
Diseasebilirubin measurement, response to xenobiotic stimulus

UGT1A4 UGT1A3 UGT1A5

1.93e-079403EFO_0004570, GO_0009410
DiseaseX-11880 measurement

UGT1A4 UGT1A3 UGT1A5

1.93e-079403EFO_0800698
Diseaseprotein-tyrosine kinase 6 measurement

UGT1A4 UGT1A3 UGT1A5

1.93e-079403EFO_0020691
DiseaseX-21448 measurement

UGT1A4 UGT1A3 UGT1A5

2.75e-0710403EFO_0800816
DiseaseUDP-glucuronosyltransferase 1-6 measurement

UGT1A4 UGT1A3 UGT1A5

2.75e-0710403EFO_0802185
Diseasebilirubin measurement, response to tenofovir

UGT1A4 UGT1A3 UGT1A5

2.75e-0710403EFO_0004570, EFO_0009279
DiseaseX-23974 measurement

UGT1A4 UGT1A3 UGT1A5

2.75e-0710403EFO_0800867
Diseasegallstones

UGT1A4 UGT1A3 ATP8B1 UGT1A5 RRP12

3.56e-07108405EFO_0004210
Diseaseinsomnia, bilirubin measurement

UGT1A4 UGT1A3 UGT1A5

3.78e-0711403EFO_0004570, EFO_0004698
Diseasehistidine betaine (hercynine) measurement

UGT1A4 UGT1A3 UGT1A5

3.78e-0711403EFO_0800972
Diseasealdosterone measurement

UGT1A4 UGT1A3 UGT1A5

3.78e-0711403EFO_0010219
DiseaseX-21796 measurement

UGT1A4 UGT1A3 UGT1A5

3.78e-0711403EFO_0800825
Diseasebiliverdin measurement

UGT1A4 UGT1A3 UGT1A5

5.03e-0712403EFO_0021033
Diseasep-cresol glucuronide measurement

UGT1A4 UGT1A3 UGT1A5

5.03e-0712403EFO_0800079
Diseaseretinol dehydrogenase 16 measurement

UGT1A4 UGT1A3 UGT1A5

6.54e-0713403EFO_0802007
Diseaselow density lipoprotein cholesterol measurement, body fat percentage

UGT1A4 UGT1A3 UGT1A5

1.55e-0617403EFO_0004611, EFO_0007800
Diseaseangiopoietin-related protein 1 measurement

UGT1A4 UGT1A3 UGT1A5

1.86e-0618403EFO_0801382
Diseasetissue factor measurement

UGT1A4 UGT1A3 UGT1A5

3.02e-0621403EFO_0010623
Diseasecholelithiasis

UGT1A4 UGT1A3 ATP8B1 UGT1A5

6.22e-0688404EFO_0004799
Diseasexanthurenate measurement

UGT1A4 UGT1A3 UGT1A5

8.23e-0629403EFO_0010551
Diseaseresponse to dolutegravir

UGT1A4 UGT1A3 UGT1A5

9.13e-0630403EFO_0600017
Diseaseurate measurement, spine bone mineral density

UGT1A4 UGT1A3 UGT1A5

6.76e-0558403EFO_0004531, EFO_0007701
Diseasepregnenetriol sulfate measurement

UGT1A4 UGT1A5

9.78e-0511402EFO_0800586
Diseaseplasma N-desmethylclozapine measurement

UGT1A4 UGT1A5

9.78e-0511402EFO_0600039
Diseasepregnenetriol disulfate measurement

UGT1A4 UGT1A5

1.38e-0413402EFO_0800587
Diseasethyroxine measurement

UGT1A4 UGT1A3 UGT1A5

1.97e-0483403EFO_0005130
Diseasehormone measurement

UGT1A4 UGT1A3 UGT1A5

2.04e-0484403EFO_0004730
DiseaseX-21441 measurement

UGT1A4 UGT1A5

2.41e-0417402EFO_0800814

Protein segments in the cluster

PeptideGeneStartEntry
MTRAFITHAGSHGVY

UGT1A3

366

P35503
FGIMFDFHSAGIHVL

ATP8B1

1111

O43520
AFTIAHESGHNFGMI

ADAMTS18

431

Q8TE60
VHFHGVSNLQEFRFM

ADIPOR2

361

Q86V24
LGRNGGSMHHLSLFF

RGS3

986

P49796
FRFGENHAIMGVAFT

RHO

146

P08100
GQTGFMHHPSFFTSE

ANAPC1

826

Q9H1A4
SFMTHRFGRNIPHFI

OR52E1

256

Q8NGJ3
MAGGHVFRNAHFDYS

HECA

311

Q9UBI9
AGQFFGHHHTDSFRM

SMPDL3B

271

Q92485
DASSGFHGGHFVHMR

HNRNPH3

186

P31942
MFINTHSGLFTHLGV

MAN1B1

441

Q9UKM7
HMQALHFSFALGAFL

MFSD4B

121

Q5TF39
GHIMEFSQDQHGSRF

PUM1

851

Q14671
TGHMFHIDFGRFLGH

PIK3C2B

1206

O00750
HYVHFSSAVMGLLFG

P2RY4

196

P51582
ASGNHFSGHGMSFNA

NCOA6

841

Q14686
VAFGHHAKFIASTGM

PRPF19

481

Q9UMS4
SRHATFENFGMAFLT

CACNA1I

1656

Q9P0X4
SSFISHHQMASGFIG

GUCY2F

111

P51841
RQLMFHFTSKHHFGF

MT-CO3

221

P00414
DFGASRFHNHTTHMS

MAP3K20

151

Q9NYL2
MHNRSQGFFFSSCHP

KRTAP25-1

1

Q3LHN0
SMVHAGDGTHRFFVA

HHIPL2

221

Q6UWX4
SRHATFSNFGMAFLT

CACNA1H

1786

O95180
GLSMHTFHGNFFVRS

SEC24B

931

O95487
GGIDTSTHFHQTFMN

DPYSL5

61

Q9BPU6
FAASGGFLHHMAGLS

POLDIP3

201

Q9BY77
VLFSIFSMHSGEGRH

OR5F1

221

O95221
FSMHSGEGRHRAFST

OR5F1

226

O95221
GGCLSHMFFIHFFTA

OR52E8

101

Q6IFG1
RFGHNVSRTFHIMFA

OR52H1

271

Q8NGJ2
SFFFRHGHRGLLTMQ

SPAG8

306

Q99932
AFFHGQMLTTRGHHT

HEPH

306

Q9BQS7
GFEQDVGSRTTHHFM

ST3GAL2

186

Q16842
GHIIHIDFGFMFESS

PI4KAP2

456

A4QPH2
HGYHRFMHSVGRVFS

OSM

196

P13725
MQAFHSLFHARPGLS

RRP12

346

Q5JTH9
EHLHNFILFRFSMGF

ABCD3

301

P28288
REEMTGRNFHTFSFG

AKAP17A

196

Q02040
GHSIGRMFASLFPHN

RPF1

256

Q9H9Y2
VQRGHSSMFVFFNGI

SPATA31D1

521

Q6ZQQ2
MTRAFITHAGSHGVY

UGT1A5

366

P35504
MAFNGFASFTRHVRT

ZNF57

231

Q68EA5
AFTSSRAFQGHLRMH

ZNF57

456

Q68EA5
FTHGIQSAAHFVMFF

TXNDC5

71

Q8NBS9
AIFGMGHHVATGTFA

SLC26A7

91

Q8TE54
MTRAFITHAGSHGVY

UGT1A4

366

P22310