Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	DH_1	MCF2 RASGRF2 PLEKHG4	1.86e-04	63	33	3	PS00741
Domain	RhoGEF	MCF2 RASGRF2 PLEKHG4	2.33e-04	68	33	3	SM00325
Domain	DH_2	MCF2 RASGRF2 PLEKHG4	2.54e-04	70	33	3	PS50010
Domain	RhoGEF	MCF2 RASGRF2 PLEKHG4	2.54e-04	70	33	3	PF00621
Domain	DH-domain	MCF2 RASGRF2 PLEKHG4	2.65e-04	71	33	3	IPR000219
Domain	-	MCF2 RASGRF2 PLEKHG4	2.65e-04	71	33	3	1.20.900.10
Domain	CRAL-TRIO_dom	MCF2 PLEKHG4	1.11e-03	28	33	2	IPR001251
Domain	-	CHD3 ABCF1 PFKFB2 DNAH12 DYNC2LI1 YLPM1	1.75e-03	746	33	6	3.40.50.300
Domain	GDS_CDC24_CS	MCF2 PLEKHG4	2.15e-03	39	33	2	IPR001331
Domain	P-loop_NTPase	CHD3 ABCF1 PFKFB2 DNAH12 DYNC2LI1 YLPM1	3.33e-03	848	33	6	IPR027417
Domain	-	APBA1 MCF2 RASGRF2 PLEKHG4	4.79e-03	391	33	4	2.30.29.30
Domain	PH_dom-like	APBA1 MCF2 RASGRF2 PLEKHG4	6.47e-03	426	33	4	IPR011993
Domain	PH	MCF2 RASGRF2 PLEKHG4	7.57e-03	229	33	3	PF00169
Domain	PHD	CHD3 UHRF2	7.75e-03	75	33	2	PF00628
Domain	Znf_PHD-finger	CHD3 UHRF2	8.57e-03	79	33	2	IPR019787
Domain	PHD	CHD3 UHRF2	1.08e-02	89	33	2	SM00249
Domain	Znf_PHD	CHD3 UHRF2	1.12e-02	91	33	2	IPR001965
Domain	ZF_PHD_2	CHD3 UHRF2	1.22e-02	95	33	2	PS50016
Pathway	REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING	MCF2 RELA PSEN2 RASGRF2	5.03e-05	97	30	4	M9400
Pubmed	Nuclear RPSA senses viral nucleic acids to promote the innate inflammatory response.	RPSA RELA	2.78e-06	3	34	2	38114488
Pubmed	Ubiquitination of ECSIT is crucial for the activation of p65/p50 NF-κBs in Toll-like receptor 4 signaling.	RELA ECSIT	5.56e-06	4	34	2	25355951
Pubmed	Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms.	APBA1 PSEN2	1.39e-05	6	34	2	12196555
Pubmed	Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR).	MCF2 PSEN2 RASGRF2	2.81e-05	60	34	3	12787561
Pubmed	Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways.	PLD3 TMEM127	3.33e-05	9	34	2	21752829
Pubmed	Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability.	RELA PSEN2	4.15e-05	10	34	2	12843241
Pubmed	A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels.	APBA1 KCNJ4	4.15e-05	10	34	2	14960569
Pubmed	Metalloproteases and gamma-secretase: new membrane partners regulating p75 neurotrophin receptor signaling?	RELA PSEN2	5.07e-05	11	34	2	17986144
Pubmed	Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin.	RELA CHD3	8.38e-05	14	34	2	17827154
Pubmed	Genetic pathway-based hierarchical clustering analysis of older adults with cognitive complaints and amnestic mild cognitive impairment using clinical and neuroimaging phenotypes.	APBA1 PSEN2	9.66e-05	15	34	2	20468060
Pubmed	Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs.	COL5A1 ABCF1 SLCO2B1	1.29e-04	100	34	3	26073538
Pubmed	Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.	CHCHD4 PLD3 ECSIT POLA2 DOP1B	1.36e-04	515	34	5	31617661
Pubmed	Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins.	APBA1 KCNJ4	1.57e-04	19	34	2	15024025
Pubmed	Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.	COL5A1 RELA PSEN2 TMEM127	1.64e-04	283	34	4	18854154
Pubmed	RP58 Represses Transcriptional Programs Linked to Nonneuronal Cell Identity and Glioblastoma Subtypes in Developing Neurons.	COL5A1 CILP	2.12e-04	22	34	2	33903225
Pubmed	Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort.	DNAH12 LCT	2.12e-04	22	34	2	19174780
Pubmed	MxA interacts with and is modified by the SUMOylation machinery.	RELA CHD3	3.21e-04	27	34	2	25447205
Pubmed	Genetic risk profiling and prediction of disease course in Crohn's disease patients.	DNAH12 LCT	3.45e-04	28	34	2	19422935
Pubmed	Use of comparative physical and sequence mapping to annotate mouse chromosome 16 and human chromosome 21.	DOP1B BRWD1	3.97e-04	30	34	2	11374901
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	CHD3 EAPP POLA2 UHRF2 METTL14 YLPM1	4.05e-04	1014	34	6	32416067
Pubmed	DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy.	RELA CHD3 PLEKHG4 BRWD1	4.27e-04	364	34	4	31391242
Pubmed	Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.	MCF2 RASGRF2	6.38e-04	38	34	2	11756498
Pubmed	Bioinformatics and cellular signaling.	MCF2 RELA ECSIT	7.49e-04	182	34	3	15102471
Pubmed	NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.	MCF2 RASGRF2	8.17e-04	43	34	2	12376548
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	CHD3 ABCF1 POLA2 USP42 YLPM1	8.78e-04	774	34	5	15302935
Pubmed	USP48 Is Upregulated by Mettl14 to Attenuate Hepatocellular Carcinoma via Regulating SIRT6 Stabilization.	RELA METTL14	9.75e-04	47	34	2	33903120
Cytoband	21q22.2	DOP1B BRWD1	2.77e-04	33	34	2	21q22.2
Cytoband	22q13.1	CACNA1I KCNJ4	1.83e-03	85	34	2	22q13.1
Cytoband	16q22.1	PLEKHG4 CDH5	3.04e-03	110	34	2	16q22.1
Cytoband	11q13	RELA SLCO2B1	3.48e-03	118	34	2	11q13
Cytoband	Ensembl 112 genes in cytogenetic band chr11q13	RELA POLA2 SLCO2B1	4.58e-03	454	34	3	chr11q13
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	MCF2 RASGRF2 PLEKHG4	1.14e-04	66	26	3	722
GeneFamily	PHD finger proteins	CHD3 UHRF2	7.37e-03	90	26	2	88
Computational	Genes in the cancer module 111.	APBA1 POLA2 CDH5 KCNJ4	2.83e-04	153	23	4	MODULE_111
Disease	Secondary Biliary Cholangitis	RELA CDH5	1.08e-03	42	34	2	C0238065
Disease	Biliary Cirrhosis, Primary, 1	RELA CDH5	1.08e-03	42	34	2	C4551595
Disease	Biliary cirrhosis	RELA CDH5	1.08e-03	42	34	2	C0023892
Disease	colitis (biomarker_via_orthology)	RELA LCT	1.08e-03	42	34	2	DOID:0060180 (biomarker_via_orthology)
Disease	Primary biliary cirrhosis	RELA CDH5	1.35e-03	47	34	2	C0008312
Disease	behavioural disinhibition measurement	CACNA1I RELA	3.39e-03	75	34	2	EFO_0006946
Disease	pulmonary hypertension (biomarker_via_orthology)	RELA CDH5	3.85e-03	80	34	2	DOID:6432 (biomarker_via_orthology)
Disease	creatinine measurement	PFKFB2 SHF PSEN2 UHRF2 DYNC2LI1	5.33e-03	995	34	5	EFO_0004518
Disease	sciatic neuropathy (biomarker_via_orthology)	CACNA1I RPSA	5.83e-03	99	34	2	DOID:11446 (biomarker_via_orthology)
Disease	pancreatic cancer (is_marker_for)	RELA SLCO2B1	6.06e-03	101	34	2	DOID:1793 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
PDYPERNRENVMEDF	PFKFB2	176	O60825
QYAEQLRMEETPTEY	ABCF1	696	Q8NE71
TRPNEPDDYMVDYFR	AGBL3	681	Q8NEM8
PDDYMVDYFRRQLPN	AGBL3	686	Q8NEM8
MNRLPDDYDPYAVEE	EAPP	1	Q56P03
FVEDPDEPQNRMTKY	CDH5	281	P33151
PYMTQEGEYLPLDQR	KCNJ4	226	P48050
PRFYDTRYNQETPME	PLD3	266	Q8IV08
MQQDEENLPYEEEIY	METTL14	86	Q9HCE5
ECMQKYPDLYPQEDE	CHCHD4	96	Q8N4Q1
MDPEEQELLNDYRYR	DOP1B	1	Q9Y3R5
PARDPQYAENEVDEM	DYNC2LI1	311	Q8TCX1
DYMNPDLEGDDRVYI	DNAH12	2186	Q6ZR08
LNPPSYEDDQEMAEE	LCT	1221	P09848
YQRKNDMDEPPPLDY	CHD3	581	Q12873
VALPPYYQPEEDDEM	CACNA1I	251	Q9P0X4
APYPRMDSYEQEEDI	APBA1	256	Q02410
DEEMSYDNNPYIRAL	COL5A1	1771	P20908
EYPDYRDIIDTPMDF	BRWD1	1346	Q9NSI6
YPTYDENEEENRPLM	MCF2	901	P10911
PEEWNLYYPMQLDLE	ECSIT	321	Q9BQ95
EVMPDLYFYRDPEEI	RPSA	196	P08865
VDYKNIPREDMPIDY	GMNC	231	A6NCL1
LEYTMENYFPELDRP	PLEKHG4	751	Q58EX7
RMRPYQSNQEDEDPD	RASGRF2	191	O14827
LYPPQEDMAIDYESF	POLA2	511	Q14181
RYDYNTVPFNEDDPM	CILP	921	O75339
IQYDEYPESGTLEMN	UHRF2	211	Q96PU4
VPENDGYMEPYEAQK	SHF	131	Q7M4L6
EYLDIRPYMSQPNGE	USP42	336	Q9H9J4
PYRYDNTSPEDMPQD	SLCO2B1	141	O94956
QLPYDPEMEEDSYDS	PSEN2	316	P49810
RMEDYLQLPDDYDTR	YLPM1	2076	P49750
SEPMEFQYLPDTDDR	RELA	281	Q04206
LSEMEENEPYPAEYE	TMEM127	211	O75204