Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ferroxidase activity	HEPHL1 HEPH	2.35e-04	6	80	2	GO:0004322
GeneOntologyMolecularFunction	oxidoreductase activity, acting on metal ions, oxygen as acceptor	HEPHL1 HEPH	2.35e-04	6	80	2	GO:0016724
HumanPheno	Abnormal electrophysiology of sinoatrial node origin	TRPM4 AKAP9 HEPHL1 FH GNB2 RYR1	5.87e-06	81	30	6	HP:0011702
Domain	MULTICOPPER_OXIDASE2	HEPHL1 HEPH	5.42e-05	3	80	2	PS00080
Domain	Cu-oxidase_2	HEPHL1 HEPH	1.08e-04	4	80	2	IPR011706
Domain	Cu-oxidase_2	HEPHL1 HEPH	1.08e-04	4	80	2	PF07731
Domain	EGF_extracell	ATRN NELL1 ADAM19 ATRNL1	1.27e-04	60	80	4	IPR013111
Domain	EGF_2	ATRN NELL1 ADAM19 ATRNL1	1.27e-04	60	80	4	PF07974
Domain	Cu-oxidase_3	HEPHL1 HEPH	1.80e-04	5	80	2	IPR011707
Domain	MULTICOPPER_OXIDASE1	HEPHL1 HEPH	1.80e-04	5	80	2	PS00079
Domain	Cu_oxidase_CS	HEPHL1 HEPH	1.80e-04	5	80	2	IPR033138
Domain	Cu-oxidase_3	HEPHL1 HEPH	1.80e-04	5	80	2	PF07732
Domain	Cu_oxidase_Cu_BS	HEPHL1 HEPH	2.69e-04	6	80	2	IPR002355
Domain	-	HEPHL1 HEPH	1.59e-03	14	80	2	2.60.40.420
Domain	EGF_3	ATRN NELL1 ADAM19 ATRNL1 LTBP3	3.38e-03	235	80	5	PS50026
Domain	Cupredoxin	HEPHL1 HEPH	3.96e-03	22	80	2	IPR008972
Domain	EPHD	BRPF3 TCF20	3.96e-03	22	80	2	PS51805
Domain	EGF-like_dom	ATRN NELL1 ADAM19 ATRNL1 LTBP3	4.32e-03	249	80	5	IPR000742
Domain	EGF_1	ATRN NELL1 ADAM19 ATRNL1 LTBP3	4.77e-03	255	80	5	PS00022
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TRIL TCF20 AKAP9 KIAA0513 MAST1 TNRC6C MED13L SLC25A25 PDZD2	5.20e-07	407	82	9	12693553
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	MDN1 PPIL4 SLTM DLAT YTHDC2 APOB MSH2 EIF3D FH ALDH3A2 NEK9 TBL3 HNRNPD PRDM2 STAU1	1.08e-06	1425	82	15	30948266
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	COL4A5 MDN1 ZGRF1 SLTM LRCH4 OSBPL9 EP300 MOCS1	2.37e-06	363	82	8	14691545
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	SP3 TTLL9 PPIL4 SLTM MSH2 EIF3D NEK9 HNRNPD EP300 STAU1	3.23e-06	653	82	10	33742100
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MDN1 TCF20 SLTM DLAT YTHDC2 MSH2 EIF3D FH TBL3 STAU1	3.23e-06	653	82	10	22586326
Pubmed	Identification of PAX6 and NFAT4 as the Transcriptional Regulators of the Long Noncoding RNA Mrhl in Neuronal Progenitors.	NFATC3 PAX6	5.49e-06	2	82	2	36317923
Pubmed	Genetic analysis of attractin homologs.	ATRN ATRNL1	5.49e-06	2	82	2	18064672
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	PLIN4 AKAP9 PVR PPIL4 OSBPL9 DLAT LTBP3 GNB2 ALDH3A2 CR1 CARS2 EP300 MOCS1 SBSN	7.01e-06	1451	82	14	30550785
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ATRN NELL1 ADAM19 ATRNL1 FUZ MAST1 DLAT LTBP3 EIF3D PAX6 MED13L CARS2 EP300	9.40e-06	1285	82	13	35914814
Pubmed	Pax6 represses androgen receptor-mediated transactivation by inhibiting recruitment of the coactivator SPBP.	TCF20 PAX6	1.64e-05	3	82	2	21935435
Pubmed	[Ceruloplasmin, hephaestin and zyklopen: the three multicopper oxidases important for human iron metabolism].	HEPHL1 HEPH	1.64e-05	3	82	2	24988611
Pubmed	Regulation of transcription of the Dnmt1 gene by Sp1 and Sp3 zinc finger proteins.	SP3 EP300	1.64e-05	3	82	2	12071960
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	MDN1 DLAT MSH2 EIF3D ALDH3A2 NEK9 TBL3 HNRNPD STAU1	1.98e-05	638	82	9	33239621
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	MDN1 TCF20 PPIL4 SLTM DLAT MSH2 EIF3D TBL3 HNRNPD SBSN STAU1	2.06e-05	989	82	11	36424410
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	ATRNL1 UNK LTBP3 MED13L	2.47e-05	71	82	4	33541421
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	ATF7 HINT1 MDN1 TCF20 PTGR1 PPIL4 SLTM MSH2 MED13L TBL3 EP300	2.59e-05	1014	82	11	32416067
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	TCF20 AKAP9 EML5 DLAT EP300	3.11e-05	152	82	5	34299191
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	MDN1 AKAP9 TNRC6C NEK9	3.24e-05	76	82	4	27542412
Pubmed	Glucagon gene transcription activation mediated by synergistic interactions of pax-6 and cdx-2 with the p300 co-activator.	PAX6 EP300	3.28e-05	4	82	2	10506141
Pubmed	ORP10, a cholesterol binding protein associated with microtubules, regulates apolipoprotein B-100 secretion.	OSBPL9 APOB	3.28e-05	4	82	2	22906437
Pubmed	Butyrate, a histone deacetylase inhibitor, activates the human IGF binding protein-3 promoter in breast cancer cells: molecular mechanism involves an Sp1/Sp3 multiprotein complex.	SP3 EP300	3.28e-05	4	82	2	11517158
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	HINT1 MDN1 AKAP9 OSBPL9 DLAT YTHDC2 TNRC6C ALDH3A2 CARS2 SLC25A25 TBL3 HNRNPD STAU1	4.60e-05	1496	82	13	32877691
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	PPIL4 DLAT YTHDC2 EIF3D FH NEK9 HNRNPD STAU1	4.81e-05	551	82	8	34728620
Pubmed	Flotillin-2 regulates epidermal growth factor receptor activation, degradation by Cbl-mediated ubiquitination, and cancer growth.	COL4A5 CLCN3 DLAT MSH2 ALDH3A2	5.30e-05	170	82	5	36470425
Pubmed	Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation.	SP3 EP300	5.47e-05	5	82	2	10362258
Pubmed	A histone methyltransferase is required for maximal response to female sex hormones.	EP300 PRDM2	5.47e-05	5	82	2	15282304
Pubmed	Trichostatin A, a histone deacetylase inhibitor, activates the IGFBP-3 promoter by upregulating Sp1 activity in hepatoma cells: alteration of the Sp1/Sp3/HDAC1 multiprotein complex.	SP3 EP300	5.47e-05	5	82	2	12200149
Pubmed	Genetic and phenotypic studies of the dark-like mutant mouse.	ATRN ATRNL1	5.47e-05	5	82	2	18821597
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	MDN1 AKAP9 PVR UNK YTHDC2 EIF3D TNRC6C NEK9 TBL3	7.21e-05	754	82	9	33060197
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	MDN1 TCF20 PPIL4 SLTM DLAT MSH2 EIF3D GNB2 NEK9 TBL3 HNRNPD STAU1	7.66e-05	1353	82	12	29467282
Pubmed	Regulation of T cell activation by HIV-1 accessory proteins: Vpr acts via distinct mechanisms to cooperate with Nef in NFAT-directed gene expression and to promote transactivation by CREB.	NFATC3 EP300	8.19e-05	6	82	2	12788643
Pubmed	Small eyes (Sey): a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse.	ATRN PAX6	8.19e-05	6	82	2	3794606
Pubmed	Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.	CACNA1B GNB2	8.19e-05	6	82	2	9238069
Pubmed	Sp1 family of transcription factors regulates the human alpha2 (XI) collagen gene (COL11A2) in Saos-2 osteoblastic cells.	SP3 EP300	8.19e-05	6	82	2	16734381
Pubmed	UTX Affects Neural Stem Cell Proliferation and Differentiation through PTEN Signaling.	PAX6 UTY	1.14e-04	7	82	2	29551674
Pubmed	The toll-like receptor 3-mediated antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice.	TICAM1 PVR	1.14e-04	7	82	2	22072781
Pubmed	Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development.	MSH2 PAX6	1.14e-04	7	82	2	8575305
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	ATRN LZTS3 KIAA0513 ATRNL1	1.14e-04	105	82	4	9628581
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	MDN1 TCF20 TTLL9 UTY ZFAND4 TBL3 EP300 RYR1	1.33e-04	638	82	8	31182584
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	CACNA1B YTHDC2 MSH2 RYR1 PRDM2	1.37e-04	208	82	5	33230847
Pubmed	Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.	TRPM4 PPIL4 MSH2 EIF3D GNB2 HNRNPD SBSN STAU1	1.37e-04	641	82	8	36057605
Pubmed	The TLR3/TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection.	TICAM1 PVR	1.52e-04	8	82	2	21998457
Pubmed	Toll-like receptor ligands induce expression of the costimulatory molecule CD155 on antigen-presenting cells.	TICAM1 PVR	1.52e-04	8	82	2	23349877
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	TCF20 SLTM YTHDC2 ALDH3A2 TBL3 STAU1	1.80e-04	349	82	6	25665578
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ATRN COL4A5 ATF7 TRPM4 PVR OSBPL9 KNDC1 MAST1 TNRC6C NEK9 EP300 PDZD2	1.88e-04	1489	82	12	28611215
Pubmed	TCF20 dysfunction leads to cortical neurogenesis defects and autistic-like behaviors in mice.	TCF20 PAX6	1.96e-04	9	82	2	32510763
Pubmed	HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.	MED13L EP300	2.44e-04	10	82	2	23746844
Pubmed	CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder.	PAX6 EP300	2.98e-04	11	82	2	36385105
Pubmed	Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300.	PAX6 EP300	2.98e-04	11	82	2	24038357
Pubmed	MARCKS-like protein, a membrane protein identified for its expression in developing neural retina, plays a role in regulating retinal cell proliferation.	PAX6 GNB2	2.98e-04	11	82	2	17688421
Pubmed	ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing.	APOB MSH2 RYR1	3.37e-04	57	82	3	23788249
Pubmed	PCP effector proteins inturned and fuzzy play nonredundant roles in the patterning but not convergent extension of mammalian neural tube.	FUZ PAX6	3.57e-04	12	82	2	21761479
Pubmed	Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis.	PAX6 STAU1	3.57e-04	12	82	2	29374155
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	HINT1 MDN1 DLAT YTHDC2 HNRNPD STAU1	3.74e-04	400	82	6	35013556
Pubmed	Applying gene expression, proteomics and single-nucleotide polymorphism analysis for complex trait gene identification.	ATRNL1 FH	4.21e-04	13	82	2	18245842
Pubmed	Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes.	LRCH4 GNB2	4.91e-04	14	82	2	9799793
Pubmed	Human transcription factor protein interaction networks.	TCF20 NFATC3 PPIL4 DLAT UNK EIF3D PAX6 TNRC6C EP300 PRDM2 STAU1	5.22e-04	1429	82	11	35140242
Pubmed	In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix.	TRPM4 RYR1	5.65e-04	15	82	2	32883967
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	MDN1 EIF3D GNB2 TBL3 HNRNPD SBSN STAU1	5.74e-04	605	82	7	28977666
Pubmed	EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.	HINT1 SLTM DLAT EIF3D FH GNB2 ALDH3A2 HNRNPD	6.18e-04	803	82	8	36517590
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	MDN1 AKAP9 SLTM FH GNB2 HNRNPD RYR1 STAU1	6.38e-04	807	82	8	30575818
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	MIER2 ATF7 SP3 TCF20 SLTM UNK PAX6 UTY	6.43e-04	808	82	8	20412781
Pubmed	Spatially distinct functions of PAX6 and NKX2.2 during gliogenesis in the ventral spinal cord.	SULF2 PAX6	6.45e-04	16	82	2	19258013
Pubmed	Loss of RNA-Binding Protein HuR Leads to Defective Ependymal Cells and Hydrocephalus.	CFAP52 PAX6	6.45e-04	16	82	2	34815315
Pubmed	Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation.	SP3 PAX6	6.45e-04	16	82	2	10868931
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	MDN1 TCF20 SLTM YTHDC2 MSH2 EIF3D TBL3 HNRNPD STAU1	6.88e-04	1024	82	9	24711643
Pubmed	A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons.	HNRNPD STAU1	7.30e-04	17	82	2	12388589
Pubmed	A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice.	AKAP9 STAU1	7.30e-04	17	82	2	20808911
Pubmed	Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube.	PAX6 EP300	7.30e-04	17	82	2	18003640
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	KRT24 UNK SLC25A25 TBL3 HNRNPD STAU1	7.95e-04	462	82	6	31138677
Pubmed	Calcineurin signaling regulates neural induction through antagonizing the BMP pathway.	NFATC3 PAX6	8.20e-04	18	82	2	24698271
Pubmed	Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/β-catenin, and mTOR signaling during corticogenesis.	PAX6 EP300	8.20e-04	18	82	2	33323119
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	TRPM4 ADIPOR1 HINT1 MDN1 PTGR1 PVR APOB FH NEK9	8.83e-04	1061	82	9	33845483
Pubmed	TRIM24 is an insulin-responsive regulator of P-bodies.	YTHDC2 TNRC6C STAU1	9.11e-04	80	82	3	35803934
Pubmed	Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations.	MAST1 PAX6	9.15e-04	19	82	2	30449657
Pubmed	Dioxin receptor is a ligand-dependent E3 ubiquitin ligase.	TBL3 EP300	9.15e-04	19	82	2	17392787
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	ATF7 MDN1 TCF20 SLTM MSH2 PAX6 TBL3 HNRNPD EP300 PRDM2	9.24e-04	1294	82	10	30804502
Pubmed	Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair.	ATF7 SP3 TCF20 AKAP9 STAU1	9.91e-04	321	82	5	32098917
Pubmed	Proteomic analysis of the mitochondrial glucocorticoid receptor interacting proteins reveals pyruvate dehydrogenase and mitochondrial 60 kDa heat shock protein as potent binding partners.	DLAT HNRNPD SBSN	1.01e-03	83	82	3	35124280
Pubmed	Molecular characterization of a novel transcription factor that controls stromelysin expression.	TCF20 PAX6	1.01e-03	20	82	2	7760812
Pubmed	The N6-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2.	HINT1 OSBPL9 EIF3D NEK9 STAU1	1.05e-03	325	82	5	36168628
Pubmed	Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes.	NFATC3 MSH2 EP300	1.09e-03	85	82	3	16051665
Pubmed	Partners of wild type Grb7 and a mutant lacking its calmodulin-binding domain.	PPIL4 STAU1	1.12e-03	21	82	2	32360748
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	CACNA1B NELL1 SLTM DLAT APOB TBL3	1.15e-03	496	82	6	31343991
Pubmed	Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling.	OSBPL9 UNK MSH2 HNRNPD STAU1	1.15e-03	332	82	5	29053956
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	ATF7 TCF20 BICRAL MSH2 MED13L HNRNPD EP300 PRDM2 STAU1	1.16e-03	1103	82	9	34189442
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	HINT1 MSH2 EIF3D GNB2 CARS2 HNRNPD	1.17e-03	498	82	6	36634849
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	COL4A5 TRPM4 MDN1 KIAA0513 LTBP3 TNRC6C MED13L EP300 RYR1	1.17e-03	1105	82	9	35748872
Pubmed	m6A epitranscriptomic modification regulates neural progenitor-to-glial cell transition in the retina.	SULF2 PAX6	1.23e-03	22	82	2	36459087
Pubmed	Huntingtin interacting proteins are genetic modifiers of neurodegeneration.	PLIN4 SP3 DLAT GNB2	1.24e-03	197	82	4	17500595
Pubmed	Cullin-3/KCTD10 complex is essential for K27-polyubiquitination of EIF3D in human hepatocellular carcinoma HepG2 cells.	PVR DLAT EIF3D	1.28e-03	90	82	3	31280863
Pubmed	Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.	APOB HEPH	1.35e-03	23	82	2	20932654
Pubmed	The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins.	SLTM DLAT FH STAU1	1.38e-03	203	82	4	35012549
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	PPIL4 SLTM TNRC6C HNRNPD STAU1	1.40e-03	347	82	5	16033648
Pubmed	Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly.	MAST1 PAX6	1.47e-03	24	82	2	33220177
Pubmed	Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.	CACNA1B CLCN3	1.47e-03	24	82	2	22534482
Pubmed	P300 Interacted With N-Myc and Regulated Its Protein Stability via Altering Its Post-Translational Modifications in Neuroblastoma.	DLAT EP300	1.59e-03	25	82	2	36708875
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	MSH2 EIF3D FH CARS2 NEK9 TBL3	1.67e-03	534	82	6	35032548
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	UNK TNRC6C GNB2 NEK9	1.79e-03	218	82	4	33378226
Pubmed	Circular RNA FOXP1 promotes tumor progression and Warburg effect in gallbladder cancer by regulating PKLR expression.	DLAT HNRNPD STAU1	1.83e-03	102	82	3	31623628
Interaction	GPBP1 interactions	SLTM UNK TNRC6C HEPHL1 HNRNPD EP300	6.07e-07	75	82	6	int:GPBP1
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_k-means-cluster#4_top-relative-expression-ranked_500	HORMAD2 EML5 ZGRF1 YTHDC2 CARS2 ZFAND4	9.30e-06	129	80	6	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_k4_500
ToppCell	PSB-critical-LOC-Epithelial-Squamous\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CAPN14 KRT24 TICAM1 PAX6 HEPHL1 SBSN	1.13e-06	183	82	6	2cf798a2371c61322484ea16fdfae0acfa94f102
Drug	Chlorambucil [305-03-3]; Down 200; 13.2uM; PC3; HT_HG-U133A	CLCN3 SIGLEC6 PVR BICRAL NEK9 MOCS1 PRDM2	4.63e-06	189	80	7	3788_DN
Drug	Levopropoxyphene napsylate [5714-90-9]; Down 200; 7.4uM; MCF7; HT_HG-U133A	ATRN KRT24 LZTS3 NFATC3 SIGLEC6 PVR MOCS1	6.08e-06	197	80	7	5503_DN
Disease	cerebellar ataxia, mental retardation and dysequlibrium syndrome (implicated_via_orthology)	ATP8A2 TUBB8B	4.83e-04	12	81	2	DOID:0050997 (implicated_via_orthology)
Disease	Colorectal Carcinoma	NELL1 ADAM19 AKAP9 MMRN2 APOB MSH2 UGT3A2 EP300	6.89e-04	702	81	8	C0009402
Disease	Endometrial Carcinoma	MSH2 FH EP300	1.04e-03	72	81	3	C0476089
Disease	uridine diphosphate measurement	MIER2 YTHDC2	1.37e-03	20	81	2	EFO_0010545
Disease	Intellectual Disability	CACNA1B TCF20 ATP8A2 PAX6 MED13L ALDH3A2	1.46e-03	447	81	6	C3714756
Disease	Brugada Syndrome (disorder)	TRPM4 AKAP9	1.98e-03	24	81	2	C1142166
Disease	Alzheimer disease, high density lipoprotein cholesterol measurement	PVR APOB	2.32e-03	26	81	2	EFO_0004612, MONDO_0004975
Disease	congestive heart failure (is_implicated_in)	EP300 RYR1	2.50e-03	27	81	2	DOID:6000 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
VTPVAQGMGSGAHTA	EP300	316	Q09472
GTIQSGSTTQFHAGM	AKAP9	3891	Q99996
QGGVASGMKHVETNT	AVIL	116	O75366
DNAQLITGMSFHGTT	ADAM19	296	Q9H013
GGVNMDHSENAIGVA	ADAM19	326	Q9H013
FQTSVQGLGHMQTGV	CCNJ	321	Q5T5M9
TGMTNGFGKHTESGS	BRPF3	996	Q9ULD4
GGVTGNDVIMHFTLN	ALDH3A2	381	P51648
HQVSSINGGCGMVVG	ATF7	266	P17544
HGIESQGGVSKGMFS	CACNA1B	671	Q00975
DGANDVGMIQTAHVG	ATP8A2	821	Q9NTI2
TAHVGVGISGNEGMQ	ATP8A2	831	Q9NTI2
GGVTMTINLAEAHGN	CAPN14	206	A8MX76
SLTGMQSSHFVGVDG	PCDHGA2	731	Q9Y5H1
KGTVSMVNNGSDQHG	PPIL4	91	Q8WUA2
GMSIGVHNIGQGCVS	OSBPL9	531	Q96SU4
ENITFGQLGTFTHNM	KIAA0513	356	O60268
VVGGAAAVSTQAMHN	LRCH4	441	O75427
MQNSHSGVNQLGGVF	PAX6	1	P26367
MSSHKGSVVAQGNGA	ADIPOR1	1	Q96A54
QAFQHVGQTLGDMAG	MDN1	3171	Q9NU22
GMQSAASHLVSQDGG	MED13L	341	Q71F56
AMGSVGSGVAHAQEF	LZTS3	36	O60299
GGQQVGMHSKGTQTA	NEK9	936	Q8TD19
GQGSGSTATVFAMAE	MMRN2	901	Q9H8L6
INVQVGFVSTGFHSM	HORMAD2	216	Q8N7B1
IVSGTMLVFGGNTHN	ATRN	561	O75882
GSINGMDITQEGVHF	CFAP52	546	Q8N1V2
MDITQEGVHFVTGGN	CFAP52	551	Q8N1V2
HEFQGGTFTISNLGM	DLAT	556	P10515
HRVFSQGAASQEGTM	PDZD2	2651	O15018
QGSSGGEVTVEMNAA	KRT24	291	Q2M2I5
QTVGFAGHSGDVMSL	GNB2	176	P62879
MVVNEGSDGGQSVYH	HINT1	96	P49773
TTLGVAQVSGMHNAS	NELL1	41	Q92832
HQSVQTEDGTGGMAR	MAST1	1391	Q9Y2H9
GFQGQISFITSMSEH	MOCS1	296	Q9NZB8
RSGVQMNTNFFHESG	APOB	896	P04114
APFTMTIDAHTNGNG	APOB	1901	P04114
SFASNTVGVQHGFMQ	BICRAL	176	Q6AI39
TVGVQHGFMQHVGIS	BICRAL	181	Q6AI39
GMVHINTDTQFGSTV	CR1	1466	P17927
QVMGNHVAVTVGGSN	FH	386	P07954
EHDGVMTGANGEVSF	EIF3D	376	O15371
MHTSAGAEGSGQALA	COL4A5	1601	P29400
GAMLIFGGNTHNDTS	ATRNL1	531	Q5VV63
QGSNMTLIGENGHST	LTBP3	86	Q9NS15
GTDTDMHGIVFQGNT	HEPHL1	651	Q6MZM0
HIQQLETGGFTMTNG	KNDC1	1651	Q76NI1
TIQGAHAAGIFSMNA	EML5	231	Q05BV3
EKVFNGLSNMGSHTG	SBSN	66	Q6UWP8
VMTAGNCGNTSVHHG	RXYLT1	356	Q9Y2B1
VTVTMGDEQGNVHSS	RYR1	1471	P21817
FGNNDMSASIGVVGV	MSH2	136	P43246
SVIGSLNGVHMFGQN	FUZ	41	Q9BT04
TTAVVSMGSGDHQFN	MIER2	31	Q8N344
MGIGVTATNFTTHNI	PRDM2	1311	Q13029
MVNAAAGAVGSVVGQ	PTGR1	146	Q14914
DNVGGEFSNTVIGQM	PTGR1	216	Q14914
GSAGEQEGAMVAATQ	HNRNPD	21	Q14103
MGSGNVATGATHTGL	PLIN4	1021	Q96Q06
ESGSMAVFHQTQGPS	PVR	71	P15151
HTATSGGQQGIMFTK	UTY	651	O14607
ASMVFGSQLDIHSGG	CARS2	261	Q9HA77
MATGSAQGNFTGHTK	TNRC6C	1	Q9HCJ0
TETDVHGVMFQGNTV	HEPH	651	Q9BQS7
DGRAGAGMITQHSSN	SLTM	986	Q9NWH9
MVSGSRGHQHQFQTG	SIGLEC6	391	O43699
SDVVAEMSGVHQGGN	CCT8L1P	461	A6NM43
TAVGTHYTMTNGGSI	CLCN3	51	P51790
VHASRSNNMGIVGGF	SLC25A25	216	Q6KCM7
MQVKVGNHTAEGTGT	STAU1	321	O95793
GSSQTMTAGINADGH	SP3	281	Q02447
QLQVAFGSHMSFGTG	TICAM1	586	Q8IUC6
VMCVAQGSGHTHSVG	TBL3	411	Q12788
MGTGVSADFSGFQSH	TRIL	751	Q7L0X0
GTMDSVHSGPFGQVF	TUBB8B	71	A6NNZ2
SVNGGHEMVVTGSNF	NFATC3	611	Q12968
STQEHQGMAGSLEGT	TCF20	771	Q9UGU0
VQGSGHFQGFSRMSS	YTHDC2	1336	Q9H6S0
DLSGMGNFVTNTHLG	TTLL9	401	Q3SXZ7
VEFQGHQVKGSATSG	ZGRF1	936	Q86YA3
FVTHGGQNSIMEAIQ	UGT3A2	366	Q3SY77
GVFLSTHGVGMNGNN	ZFAND4	621	Q86XD8
GSIEGQSAGAASHAM	UNK	181	Q9C0B0
MEQGGAHFINAFVTT	SULF2	71	Q8IWU5
VGVAVRDHQMASTGG	TRPM4	166	Q8TD43
IQMIGSHNGGEVSDV	ZNF266	66	Q14584