Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	acetylcholine receptor regulator activity	SPDYE2B SPDYE6 SPDYE2	1.28e-05	27	34	3	GO:0030548
GeneOntologyMolecularFunction	neurotransmitter receptor regulator activity	SPDYE2B SPDYE6 SPDYE2	1.44e-05	28	34	3	GO:0099602
GeneOntologyMolecularFunction	modification-dependent protein binding	ABRAXAS2 SETD5 PHIP CDY1	4.00e-04	206	34	4	GO:0140030
GeneOntologyMolecularFunction	transcription corepressor activity	CDY2A SPEN SETD5 CDY1	5.96e-04	229	34	4	GO:0003714
GeneOntologyBiologicalProcess	positive regulation of cyclin-dependent protein serine/threonine kinase activity	SPDYE2B SPDYE6 SPDYE2	1.00e-05	25	35	3	GO:0045737
GeneOntologyBiologicalProcess	positive regulation of cyclin-dependent protein kinase activity	SPDYE2B SPDYE6 SPDYE2	1.42e-05	28	35	3	GO:1904031
GeneOntologyBiologicalProcess	nuclear migration	CDC42BPA SUN2 FHOD1	2.58e-05	34	35	3	GO:0007097
GeneOntologyBiologicalProcess	nucleus localization	CDC42BPA SUN2 FHOD1	5.65e-05	44	35	3	GO:0051647
GeneOntologyBiologicalProcess	actin filament-based process	TENM1 IQSEC1 CDC42BPA MYO15A SUN2 KCNJ8 FHOD1 IQSEC2	1.15e-04	912	35	8	GO:0030029
GeneOntologyBiologicalProcess	transcription by RNA polymerase III	TENM1 POLR3E SETD5	1.66e-04	63	35	3	GO:0006383
GeneOntologyBiologicalProcess	positive regulation of protein serine/threonine kinase activity	TENM1 SPDYE2B SPDYE6 SPDYE2	3.10e-04	193	35	4	GO:0071902
Domain	Speedy	SPDYE2B SPDYE6 SPDYE2	9.85e-07	11	35	3	IPR020984
Domain	Spy1	SPDYE2B SPDYE6 SPDYE2	9.85e-07	11	35	3	PF11357
Domain	TFSII	TCEA2 TCEA3	1.02e-05	3	35	2	IPR006289
Domain	IQ_SEC7_PH	IQSEC1 IQSEC2	1.02e-05	3	35	2	PF16453
Domain	IQSEC_PH	IQSEC1 IQSEC2	1.02e-05	3	35	2	IPR033742
Domain	TF_IIS-rel	TCEA2 TCEA3	2.04e-05	4	35	2	IPR016492
Domain	Znf_TFIIS	TCEA2 TCEA3	5.09e-05	6	35	2	IPR001222
Domain	ZnF_C2C2	TCEA2 TCEA3	5.09e-05	6	35	2	SM00440
Domain	ZF_TFIIS_1	TCEA2 TCEA3	5.09e-05	6	35	2	PS00466
Domain	ZF_TFIIS_2	TCEA2 TCEA3	5.09e-05	6	35	2	PS51133
Domain	TFIIS_C	TCEA2 TCEA3	5.09e-05	6	35	2	PF01096
Domain	TFS2M	TCEA2 TCEA3	7.12e-05	7	35	2	SM00510
Domain	TFIIS_M	TCEA2 TCEA3	7.12e-05	7	35	2	PF07500
Domain	TFIIS_cen_dom	TCEA2 TCEA3	9.49e-05	8	35	2	IPR003618
Domain	-	TCEA2 TCEA3	9.49e-05	8	35	2	1.10.472.30
Domain	TFIIS_CENTRAL	TCEA2 TCEA3	9.49e-05	8	35	2	PS51321
Domain	TFIIS/CRSP70_N_sub	TCEA2 TCEA3	1.52e-04	10	35	2	IPR003617
Domain	TFS2N	TCEA2 TCEA3	1.52e-04	10	35	2	SM00509
Domain	Chromo_dom_subgr	CDY2A CDY1	1.52e-04	10	35	2	IPR017984
Domain	PH_DOMAIN	IQSEC1 CDC42BPA ARHGEF16 IQSEC2 PHLPP2	1.61e-04	279	35	5	PS50003
Domain	-	TCEA2 TCEA3	2.63e-04	13	35	2	1.20.930.10
Domain	TFIIS_N	TCEA2 TCEA3	2.63e-04	13	35	2	PS51319
Domain	Med26	TCEA2 TCEA3	2.63e-04	13	35	2	PF08711
Domain	TFIIS_N	TCEA2 TCEA3	3.06e-04	14	35	2	IPR017923
Domain	IQ	IQSEC1 MYO15A IQSEC2	3.16e-04	71	35	3	PF00612
Domain	Sec7	IQSEC1 IQSEC2	3.53e-04	15	35	2	PF01369
Domain	Sec7_alpha_orthog	IQSEC1 IQSEC2	3.53e-04	15	35	2	IPR023394
Domain	-	IQSEC1 IQSEC2	3.53e-04	15	35	2	1.10.1000.11
Domain	Sec7	IQSEC1 IQSEC2	4.03e-04	16	35	2	SM00222
Domain	Sec7_dom	IQSEC1 IQSEC2	4.03e-04	16	35	2	IPR000904
Domain	SEC7	IQSEC1 IQSEC2	4.03e-04	16	35	2	PS50190
Domain	Crotonase_core_superfam	CDY2A CDY1	4.56e-04	17	35	2	IPR001753
Domain	ECH_1	CDY2A CDY1	4.56e-04	17	35	2	PF00378
Domain	IQ_motif_EF-hand-BS	IQSEC1 MYO15A IQSEC2	6.33e-04	90	35	3	IPR000048
Domain	IQ	IQSEC1 MYO15A IQSEC2	6.97e-04	93	35	3	PS50096
Domain	-	IQSEC1 CDC42BPA ARHGEF16 IQSEC2 PHLPP2	7.59e-04	391	35	5	2.30.29.30
Domain	Chromo	CDY2A CDY1	1.08e-03	26	35	2	PF00385
Domain	PH_dom-like	IQSEC1 CDC42BPA ARHGEF16 IQSEC2 PHLPP2	1.11e-03	426	35	5	IPR011993
Domain	CHROMO_2	CDY2A CDY1	1.25e-03	28	35	2	PS50013
Domain	CHROMO_1	CDY2A CDY1	1.25e-03	28	35	2	PS00598
Domain	Chromodomain-like	CDY2A CDY1	1.63e-03	32	35	2	IPR016197
Domain	CHROMO	CDY2A CDY1	1.74e-03	33	35	2	SM00298
Domain	Chromo/shadow_dom	CDY2A CDY1	1.74e-03	33	35	2	IPR000953
Domain	PH	IQSEC1 CDC42BPA ARHGEF16 IQSEC2	1.75e-03	278	35	4	SM00233
Domain	PH_domain	IQSEC1 CDC42BPA ARHGEF16 IQSEC2	1.80e-03	280	35	4	IPR001849
Pubmed	Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene.	SPDYE2B SPDYE6 SPDYE2	7.81e-08	9	35	3	36272447
Pubmed	Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.	SPDYE2B SPDYE6 SPDYE2	2.65e-07	13	35	3	15611625
Pubmed	Characterization of a new family of cyclin-dependent kinase activators.	SPDYE2B SPDYE6 SPDYE2	6.29e-07	17	35	3	15574121
Pubmed	A tandem duplication of BRCA1 exons 1-19 through DHX8 exon 2 in four families with hereditary breast and ovarian cancer syndrome.	BRCA1 DHX8	9.84e-07	2	35	2	30191368
Pubmed	Transcription factor genes and the developing eye: a genetic perspective.	TCEA2 TCEA3	9.84e-07	2	35	2	8875254
Pubmed	Association of muscarinic M₃ receptors and Kir6.1 with caveolae in human detrusor muscle.	CHRM3 KCNJ8	9.84e-07	2	35	2	22410194
Pubmed	Evolution of the Cdk-activator Speedy/RINGO in vertebrates.	SPDYE6 SPDYE2	2.95e-06	3	35	2	22763696
Pubmed	The BRCA1-interacting protein Abraxas is required for genomic stability and tumor suppression.	ABRAXAS2 BRCA1	2.95e-06	3	35	2	25066119
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	ABRAXAS2 AMBRA1 EIF3D BRCA1 POLR3E SUN2 DHX8 PHLPP2	5.56e-06	1005	35	8	19615732
Pubmed	Subunit-selective N-Methyl-d-aspartate (NMDA) Receptor Signaling through Brefeldin A-resistant Arf Guanine Nucleotide Exchange Factors BRAG1 and BRAG2 during Synapse Maturation.	IQSEC1 IQSEC2	5.90e-06	4	35	2	26884337
Pubmed	A long-range restriction map of deletion interval 6 of the human Y chromosome: a region frequently deleted in azoospermic males.	CDY2A CDY1	5.90e-06	4	35	2	9806824
Pubmed	Identification and characterization of the cynomolgus monkey chromodomain gene cynCDY, an orthologue of the human CDY gene family.	CDY2A CDY1	5.90e-06	4	35	2	12149400
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	IQSEC1 EIF3D KIDINS220 CDC42BPA SPEN SUN2 DHX8 CFAP45	9.53e-06	1082	35	8	38697112
Pubmed	Heterogeneity and tissue-specific expression of eukaryotic transcription factor S-II-related protein mRNA.	TCEA2 TCEA3	9.82e-06	5	35	2	1917889
Pubmed	Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome.	CDY2A CDY1	9.82e-06	5	35	2	10192397
Pubmed	Transcription elongation factor Tcea3 regulates the pluripotent differentiation potential of mouse embryonic stem cells via the Lefty1-Nodal-Smad2 pathway.	TCEA2 TCEA3	9.82e-06	5	35	2	23169579
Pubmed	AMPA receptor signaling through BRAG2 and Arf6 critical for long-term synaptic depression.	IQSEC1 IQSEC2	1.47e-05	6	35	2	20547133
Pubmed	Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.	ABRAXAS2 BRCA1	1.47e-05	6	35	2	17525340
Pubmed	NBA1/MERIT40 and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36-containing complexes.	ABRAXAS2 BRCA1	2.06e-05	7	35	2	21282113
Pubmed	Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.	ABRAXAS2 BRCA1	2.06e-05	7	35	2	31253574
Pubmed	Mammalian chromodomain proteins: their role in genome organisation and expression.	CDY2A CDY1	2.74e-05	8	35	2	10655032
Pubmed	Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis.	CDY2A CDY1	2.74e-05	8	35	2	12072557
Pubmed	NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control.	ABRAXAS2 BRCA1	4.40e-05	10	35	2	19261749
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	IQSEC1 CDC42BPA NETO2 IQSEC2	4.56e-05	197	35	4	36604605
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	EIF3D KIDINS220 CDC42BPA BRCA1 SPEN SETD5 SUN2 DHX8	9.62e-05	1497	35	8	31527615
Pubmed	Y Chromosome Infertility	CDY2A CDY1	1.17e-04	16	35	2	20301513
Pubmed	HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors.	TCEA2 TCEA3	1.33e-04	17	35	2	1559613
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	TENM1 KIDINS220 CDC42BPA NETO2 SUN2	1.42e-04	504	35	5	34432599
Pubmed	A crucial role for Arf6 in the response of commissural axons to Slit.	IQSEC1 IQSEC2	1.66e-04	19	35	2	30674481
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	TENM1 CDC42BPA LMO7 PHIP SPDYE2	2.17e-04	552	35	5	10737800
Pubmed	Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.	KIDINS220 CHRM3	2.24e-04	22	35	2	21507922
Pubmed	Functional coherence of the human Y chromosome.	CDY2A CDY1	2.91e-04	25	35	2	9381176
Pubmed	HERC2 Facilitates BLM and WRN Helicase Complex Interaction with RPA to Suppress G-Quadruplex DNA.	EIF3D BRCA1	4.49e-04	31	35	2	30279242
Pubmed	The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor.	TCEA2 TCEA3	5.09e-04	33	35	2	9765201
Pubmed	SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.	ABRAXAS2 KIDINS220 LMO7 SUN2	5.51e-04	378	35	4	34315543
Pubmed	A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.	AMBRA1 PHIP	6.41e-04	37	35	2	16949367
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	EIF3D BRCA1 SPEN LMO7 DHX8	7.46e-04	724	35	5	36232890
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	IQSEC1 AMBRA1 BRCA1 SETD5 PHIP SUN2	7.88e-04	1116	35	6	31753913
Pubmed	Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.	MYO15A CHRM3	9.06e-04	44	35	2	27534441
Cytoband	7q22.1	SPDYE2B SPDYE6 SPDYE2	8.97e-05	113	35	3	7q22.1
Cytoband	14q23.1	GPR135 ARMH4	5.97e-04	47	35	2	14q23.1
Cytoband	Ensembl 112 genes in cytogenetic band chr7q22	SPDYE2B SPDYE6 SPDYE2	6.26e-04	219	35	3	chr7q22
Cytoband	22q13.1	EIF3D SUN2	1.94e-03	85	35	2	22q13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr14q23	GPR135 ARMH4	4.45e-03	130	35	2	chr14q23
Cytoband	Ensembl 112 genes in cytogenetic band chr3p25	IQSEC1 SETD5	6.26e-03	155	35	2	chr3p25
Cytoband	Ensembl 112 genes in cytogenetic band chr16q22	FHOD1 PHLPP2	8.62e-03	183	35	2	chr16q22
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	TCEA3 SPEN ARHGEF16	1.50e-02	681	35	3	chr1p36
GeneFamily	Speedy/RINGO cell cycle regulator family	SPDYE2B SPDYE6 SPDYE2	3.42e-07	12	22	3	756
GeneFamily	WD repeat domain containing\|DDB1 and CUL4 associated factors	AMBRA1 PHIP	2.14e-04	18	22	2	498
Coexpression	THUM_SYSTOLIC_HEART_FAILURE_DN	CDC42BPA POLR3E LMO7 KCNJ8 ARMH4	1.22e-05	227	35	5	M18441
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-enterocyte_of_epithelium_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LMO7 SUN2 SEMA4G PHLPP2	8.97e-06	168	35	4	03896466698a79f7f1ad862cb7e05585260e2a5a
ToppCell	droplet-Fat-Scat-21m-Endothelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCEA2 CDC42BPA LMO7 SEMA4G	1.01e-05	173	35	4	f13124b4cf2ac1dc2895f90f5487d6ac681b0ba4
Drug	Naltrexone hydrochloride dihydrate [16676-29-2]; Down 200; 9.6uM; MCF7; HT_HG-U133A	KIDINS220 SPEN SEMA4G IQSEC2 DHX8 PHLPP2	3.79e-07	193	34	6	2209_DN
Drug	Proparacaine hydrochloride [5875-06-9]; Up 200; 12uM; PC3; HT_HG-U133A	KIDINS220 CDC42BPA ARHGEF16 LMO7 SEMA4G CFAP45	4.40e-07	198	34	6	6332_UP
Drug	ICI 182,780; Up 200; 1uM; MCF7; HT_HG-U133A	TENM1 ADM CDC42BPA CHRM3 SUN2	9.95e-06	195	34	5	1630_UP
Drug	cobalt(II) chloride hexahydrate; Up 200; 100uM; MCF7; HG-U133A	IQSEC1 ADM AMBRA1 CDC42BPA DHX8	1.02e-05	196	34	5	379_UP
Drug	Benzonatate [104-31-4]; Up 200; 6.6uM; MCF7; HT_HG-U133A	SEMA4G FHOD1 IQSEC2 PHLPP2 CFAP45	1.05e-05	197	34	5	5435_UP
Drug	Edrophonium chloride [116-38-1]; Down 200; 19.8uM; PC3; HT_HG-U133A	TENM1 AMBRA1 KIDINS220 ARHGEF16 SEMA4G	1.10e-05	199	34	5	6655_DN
Drug	Lycorine hydrochloride [2188-68-3]; Up 200; 12.4uM; MCF7; HT_HG-U133A	ABRAXAS2 ADM AMBRA1 LMO7	1.12e-04	168	34	4	4365_UP
Drug	Trichostatin A, Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA	SPEN NETO2 POLR3E PHIP	1.39e-04	178	34	4	1112_DN
Drug	5707885; Down 200; 50uM; PC3; HT_HG-U133A	GPR135 CDC42BPA KCNJ8 PHLPP2	1.83e-04	191	34	4	6390_DN
Drug	pioglitazone HCl; Up 200; 10uM; PC3; HT_HG-U133A	ADM AMBRA1 SEMA4G PHLPP2	1.83e-04	191	34	4	5977_UP
Drug	Y-27632; Up 200; 3uM; MCF7; HT_HG-U133A_EA	AMBRA1 CDC42BPA CHRM3 FHOD1	1.90e-04	193	34	4	948_UP
Drug	0173570-0000 [211245-44-2]; Up 200; 10uM; MCF7; HT_HG-U133A	CDC42BPA MYO15A CHRM3 CFAP45	1.90e-04	193	34	4	4712_UP
Drug	troglitazone; Up 200; 10uM; MCF7; HT_HG-U133A	ADM CDC42BPA ARHGEF16 IQSEC2	1.90e-04	193	34	4	1657_UP
Drug	LY 294002; Down 200; 10uM; MCF7; HT_HG-U133A	IQSEC1 ADM CDC42BPA FHOD1	1.94e-04	194	34	4	5599_DN
Drug	Benfluorex hydrochloride [23642-66-2]; Up 200; 10.4uM; MCF7; HT_HG-U133A	CDC42BPA MYO15A CHRM3 CFAP45	1.94e-04	194	34	4	2621_UP
Drug	Phentolamine hydrochloride [73-05-2]; Down 200; 12.6uM; PC3; HT_HG-U133A	CDC42BPA BRCA1 CHRM3 CFAP45	1.94e-04	194	34	4	3779_DN
Drug	Tiapride hydrochloride [51012-33-0]; Up 200; 11uM; MCF7; HT_HG-U133A	ADM KIDINS220 CDC42BPA CHRM3	1.98e-04	195	34	4	4686_UP
Drug	Clomiphene citrate (Z,E) [50-41-9]; Down 200; 6.6uM; PC3; HT_HG-U133A	TENM1 AMBRA1 ARHGEF16 LMO7	1.98e-04	195	34	4	6648_DN
Drug	Thiocolchicoside [602-41-5]; Up 200; 7uM; MCF7; HT_HG-U133A	CDC42BPA FHOD1 IQSEC2 CFAP45	1.98e-04	195	34	4	2875_UP
Drug	Quinic acid [86-68-0]; Down 200; 19.6uM; PC3; HT_HG-U133A	TENM1 ARHGEF16 KCNJ8 FHOD1	2.02e-04	196	34	4	7317_DN
Drug	Trimipramine maleate salt [521-78-8]; Down 200; 9.8uM; PC3; HT_HG-U133A	IQSEC1 CDC42BPA ARHGEF16 LMO7	2.02e-04	196	34	4	4083_DN
Drug	Ascorbic acid [50-81-7]; Up 200; 22.4uM; MCF7; HT_HG-U133A	TENM1 CHRM3 FHOD1 PHLPP2	2.02e-04	196	34	4	3225_UP
Drug	Clofilium tosylate [92953-10-1]; Down 200; 7.8uM; MCF7; HT_HG-U133A	AMBRA1 KIDINS220 CDC42BPA SEMA4G	2.02e-04	196	34	4	3187_DN
Drug	Ethoxyquin [91-53-2]; Up 200; 18.4uM; PC3; HT_HG-U133A	KIDINS220 IQSEC2 PHLPP2 CFAP45	2.02e-04	196	34	4	4321_UP
Drug	Chlorpropamide [94-20-2]; Up 200; 14.4uM; MCF7; HT_HG-U133A	GPR135 CDC42BPA FHOD1 PHLPP2	2.02e-04	196	34	4	3210_UP
Drug	Fluocinonide [356-12-7]; Down 200; 8uM; MCF7; HT_HG-U133A	ADM GPR135 SEMA4G IQSEC2	2.06e-04	197	34	4	3933_DN
Drug	Oxolinic acid [14698-29-4]; Up 200; 15.4uM; MCF7; HT_HG-U133A	KIDINS220 CDC42BPA SEMA4G IQSEC2	2.06e-04	197	34	4	5519_UP
Drug	Zaprinast [37762-06-4]; Down 200; 14.8uM; MCF7; HT_HG-U133A	ADM CDC42BPA IQSEC2 CFAP45	2.06e-04	197	34	4	3226_DN
Drug	Phenindione [83-12-5]; Up 200; 18uM; PC3; HT_HG-U133A	GPR135 AMBRA1 PHLPP2 CFAP45	2.06e-04	197	34	4	7289_UP
Drug	Canrenoic acid potassium salt [2181-04-6]; Up 200; 10uM; PC3; HT_HG-U133A	AMBRA1 ARHGEF16 KCNJ8 CFAP45	2.10e-04	198	34	4	2065_UP
Drug	Mephenesin [59-47-2]; Up 200; 22uM; MCF7; HT_HG-U133A	ADM MYO15A CHRM3 SEMA4G	2.10e-04	198	34	4	4698_UP
Drug	Cefotiam hydrochloride; Down 200; 7.2uM; HL60; HT_HG-U133A	KIDINS220 CDC42BPA SEMA4G IQSEC2	2.10e-04	198	34	4	2458_DN
Drug	Mianserine hydrochloride [21535-47-7]; Down 200; 13.2uM; PC3; HT_HG-U133A	ARHGEF16 LMO7 KCNJ8 FHOD1	2.10e-04	198	34	4	5786_DN
Drug	Evoxine [522-11-2]; Up 200; 11.6uM; MCF7; HT_HG-U133A	ADM GPR135 KCNJ8 CFAP45	2.10e-04	198	34	4	4704_UP
Drug	Bucladesine sodium salt [16980-89-5]; Up 200; 7.8uM; PC3; HT_HG-U133A	TENM1 ARHGEF16 LMO7 CFAP45	2.10e-04	198	34	4	5886_UP
Drug	Mimosine [500-44-7]; Up 200; 20.2uM; MCF7; HT_HG-U133A	TENM1 GPR135 SPEN IQSEC2	2.10e-04	198	34	4	2638_UP
Drug	Hydroquinine hydrobromide hydrate [304695-81-6]; Up 200; 9.4uM; HL60; HG-U133A	IQSEC1 MYO15A SUN2 SEMA4G	2.10e-04	198	34	4	1775_UP
Drug	Naftifine hydrochloride [65473-14-5]; Down 200; 12.4uM; MCF7; HT_HG-U133A	IQSEC1 CDC42BPA ARHGEF16 FHOD1	2.10e-04	198	34	4	7032_DN
Drug	Moxonidine [75438-57-2]; Up 200; 16.6uM; HL60; HT_HG-U133A	KIDINS220 CDC42BPA PHLPP2 CFAP45	2.14e-04	199	34	4	2923_UP
Drug	Propylthiouracil [51-52-5]; Down 200; 23.4uM; PC3; HT_HG-U133A	CDC42BPA ARHGEF16 IQSEC2 CFAP45	2.18e-04	200	34	4	4076_DN
Drug	Propantheline bromide [50-34-0]; Up 200; 9uM; MCF7; HT_HG-U133A	TENM1 GPR135 KIDINS220 MYO15A	2.18e-04	200	34	4	3352_UP
Disease	Spermatogenic failure, Y-linked, 2	CDY2A CDY1	1.44e-04	16	33	2	cv:C1839071
Disease	Spermatogenic Failure, Nonobstructive, Y-Linked	CDY2A CDY1	1.44e-04	16	33	2	C1839071
Disease	SPERMATOGENIC FAILURE, Y-LINKED, 2	CDY2A CDY1	1.44e-04	16	33	2	415000
Disease	L-Selectin measurement	TENM1 POLR3E	5.53e-04	31	33	2	EFO_0008202
Disease	esophagus squamous cell carcinoma (is_implicated_in)	BRCA1 SPEN	1.17e-03	45	33	2	DOID:3748 (is_implicated_in)
Disease	Salivary Gland Neoplasms	SPEN NETO2	1.27e-03	47	33	2	C0036095
Disease	prostate carcinoma	SPEN LMO7 PHIP SUN2 PHLPP2	2.92e-03	891	33	5	EFO_0001663
Disease	aspartate aminotransferase measurement	TCEA2 BRCA1 MYO15A CHRM3 PHIP	3.11e-03	904	33	5	EFO_0004736
Disease	neutrophil count	IQSEC1 KIDINS220 CDC42BPA BRCA1 IQSEC2 CFAP45	3.90e-03	1382	33	6	EFO_0004833
Disease	Neurodevelopmental Disorders	SETD5 IQSEC2	4.87e-03	93	33	2	C1535926
Disease	obsessive-compulsive disorder	GPR135 LMO7	5.61e-03	100	33	2	EFO_0004242
Disease	Adenoid Cystic Carcinoma	BRCA1 NETO2	5.61e-03	100	33	2	C0010606
Disease	pancreatic cancer (is_implicated_in)	ADM BRCA1	6.98e-03	112	33	2	DOID:1793 (is_implicated_in)
Disease	lymphocyte measurement	IQSEC1 ABRAXAS2	7.60e-03	117	33	2	EFO_0803546

Protein segments in the cluster

Peptide	Gene	Start	Entry
NNARRRTSRSTKANY	CDY1	76	Q9Y6F8
NNARRRTSRSTKANY	CDY2A	76	Q9Y6F7
RFRRNTQQQMSYREQ	ABRAXAS2	96	Q15018
ALYSIKVMNRRRRNG	ARMH4	731	Q86TY3
QQQSMKRSNRRKYGR	CHRM3	296	P20309
RRNLRNQSYRAAMKG	ARHGEF16	146	Q5VV41
SRRDSIRQRSMRYQQ	AMBRA1	736	Q9C0C7
IRQRSMRYQQNRLRS	AMBRA1	741	Q9C0C7
DAARIRVKRYRQSMN	ADM	86	P35318
TALNRRDTYRRRQMQ	KIDINS220	896	Q9ULH0
SMRRNNSIRRNNSSL	KCNJ8	391	Q15842
ARQRYQQMRRSLVKF	MYO15A	1941	Q9UKN7
RQYQMNKNFERLRSS	IQSEC1	146	Q6DN90
ARTIQTAFRQYRMNK	IQSEC2	351	Q5JU85
SNRSRNKARYRTKAV	CFAP45	16	Q9UL16
YSLRNRDMKAALRRQ	OR14L1P	291	Q8NHC6
QNQKSTVPSRRRMYS	LMO7	791	Q8WWI1
QSMGYRNRAKRLLQS	BRCA1	126	P38398
RNRYANRLGACNRMS	GPR135	431	Q8IZ08
ARTQKTAYQRNRMRF	EIF3D	86	O15371
TAYQRNRMRFAQRNL	EIF3D	91	O15371
QATYRERNKTRGRMI	FHOD1	1001	Q9Y613
IFSKNYRVRRNMIQS	POLR3E	656	Q9NVU0
NKVKSRYRSRSRSQS	DHX8	216	Q14562
RYRTSSAQRLKRQKQ	SETD5	621	Q9C0A6
QELRMNYNSQSRKRK	TENM1	51	Q9UKZ4
NYQKMRRSSTASRCI	NETO2	421	Q8NC67
RKQMVRNINNKRRYS	CDC42BPA	1531	Q5VT25
KRRFQLYRSMNSRAR	SPDYE2B	336	A6NHP3
LYRSMNSRARKNRSQ	SPDYE2B	341	A6NHP3
SRLRRMNGNSYVLLR	SEMA4G	786	Q9NTN9
TQSYRKQMEQSRRKQ	SPEN	1166	Q96T58
MRTRNQGRRTAFYNE	PHIP	1766	Q8WWQ0
MSRRSQRLTRYSQGD	SUN2	1	Q9UH99
MKRNGSRNCLNRRSR	PHLPP2	1	Q6ZVD8
KRRFQLYRSMNSRAR	SPDYE2	336	Q495Y8
LYRSMNSRARKNRSQ	SPDYE2	341	Q495Y8
LYRSMNSRARKNRSQ	SPDYE6	341	P0CI01
DMKYRNRVRSRISNL	TCEA3	231	O75764
TDMKYKNRVRSRISN	TCEA2	181	Q15560