Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionandrosterone dehydrogenase (B-specific) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.68e-0941824GO:0047042
GeneOntologyMolecularFunctionketoreductase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.68e-0941824GO:0045703
GeneOntologyMolecularFunctionchlordecone reductase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.68e-0941824GO:0047743
GeneOntologyMolecularFunctiontrans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.32e-0851824GO:0047115
GeneOntologyMolecularFunction15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.32e-0851824GO:0047020
GeneOntologyMolecularFunction17-beta-ketosteroid reductase (NADPH) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.32e-0851824GO:0072555
GeneOntologyMolecularFunction17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.32e-0851824GO:0047006
GeneOntologyMolecularFunctionlithocholic acid binding

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.32e-0851824GO:1902121
GeneOntologyMolecularFunctionketosteroid monooxygenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.32e-0851824GO:0047086
GeneOntologyMolecularFunctionDelta4-3-oxosteroid 5beta-reductase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.32e-0851824GO:0047787
GeneOntologyMolecularFunctiongeranylgeranyl reductase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.88e-0861824GO:0045550
GeneOntologyMolecularFunction17-beta-hydroxysteroid dehydrogenase (NADP+) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.29e-0771824GO:0072582
GeneOntologyMolecularFunction5alpha-androstane-3beta,17beta-diol dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.54e-0781824GO:0047024
GeneOntologyMolecularFunctionandrosterone dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.54e-0781824GO:0047023
GeneOntologyMolecularFunctionenone reductase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.54e-0781824GO:0035671
GeneOntologyMolecularFunctionandrostan-3-alpha,17-beta-diol dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.12e-0791824GO:0047044
GeneOntologyMolecularFunctionNADP+ binding

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.12e-0791824GO:0070401
GeneOntologyMolecularFunctiontestosterone 17-beta-dehydrogenase (NADP+) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.34e-06101824GO:0047045
GeneOntologyMolecularFunctionbile acid binding

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.34e-06101824GO:0032052
GeneOntologyMolecularFunctionheparan sulfate proteoglycan binding

SEMA5A ITGA2 APOE SLIT2 HRG

5.92e-06291825GO:0043395
GeneOntologyMolecularFunctionaldose reductase (NADPH) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.22e-06141824GO:0004032
GeneOntologyMolecularFunctionretinal dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.22e-06141824GO:0001758
GeneOntologyMolecularFunctionproteoglycan binding

SEMA5A ITGA2 APOE SLIT2 NF1 HRG

6.76e-06511826GO:0043394
GeneOntologyMolecularFunctionaldo-keto reductase (NADPH) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3 KCNAB3

9.82e-06321825GO:0004033
GeneOntologyMolecularFunctionNADP binding

AKR1C4 H6PD AKR1C1 AKR1C2 AKR1C3 NOS3

2.13e-05621826GO:0050661
GeneOntologyMolecularFunctionestradiol 17-beta-dehydrogenase [NAD(P)+] activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.89e-05201824GO:0004303
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

AKR1C4 AKR1C1 AKR1C2 AKR1C3 NOS3

3.02e-05401825GO:0016709
GeneOntologyMolecularFunctionall-trans-retinol dehydrogenase (NAD+) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.15e-05241824GO:0004745
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

AKR1C4 AKR1C1 AKR1C2 AKR1C3 FAR1

7.42e-05481825GO:0016620
GeneOntologyMolecularFunctionalcohol dehydrogenase (NAD+) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.53e-05261824GO:0004022
GeneOntologyMolecularFunctionNADPH binding

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.53e-05261824GO:0070402
GeneOntologyMolecularFunctionalcohol dehydrogenase (NADP+) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.95e-05271824GO:0008106
GeneOntologyMolecularFunctiontestosterone dehydrogenase [NAD(P)+] activity

AKR1C4 AKR1C1 AKR1C3

1.16e-04111823GO:0030283
GeneOntologyMolecularFunctionorganic acid binding

L1CAM GLRA3 SHMT1 AKR1C4 AKR1C1 AKR1C2 RYR2 AKR1C3 SIGLEC11 NOS3

1.17e-0425418210GO:0043177
GeneOntologyMolecularFunctionalcohol dehydrogenase [NAD(P)+] activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.52e-04301824GO:0018455
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors

AKR1C4 AKR1C1 AKR1C2 AKR1C3 FAR1

1.56e-04561825GO:0016903
GeneOntologyMolecularFunctionaxon guidance receptor activity

L1CAM SEMA5A HMCN2

1.99e-04131823GO:0008046
GeneOntologyMolecularFunctionsteroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.22e-04331824GO:0033764
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.50e-04341824GO:0016628
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-CH group of donors

AKR1C4 ACAD10 AKR1C1 AKR1C2 AKR1C3

2.53e-04621825GO:0016627
GeneOntologyMolecularFunctioncarboxylic acid binding

L1CAM GLRA3 SHMT1 AKR1C4 AKR1C1 AKR1C2 AKR1C3 SIGLEC11 NOS3

3.57e-042391829GO:0031406
GeneOntologyMolecularFunctionsteroid dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.28e-04391824GO:0016229
GeneOntologyMolecularFunctionryanodine-sensitive calcium-release channel activity

RYR1 RYR2

4.90e-0441822GO:0005219
GeneOntologyMolecularFunctionindanol dehydrogenase activity

AKR1C1 AKR1C2

4.90e-0441822GO:0047718
GeneOntologyMolecularFunctionvery-low-density lipoprotein particle receptor binding

RELN APOE

4.90e-0441822GO:0070326
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH3 DNAH10 DNAH11

5.49e-04181823GO:0008569
GeneOntologyMolecularFunctionNAD transmembrane transporter activity

SLC25A51 SLC25A52

8.11e-0451822GO:0051724
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

AKR1C4 H6PD AKR1C1 AKR1C2 AKR1C3 KCNAB3

1.10e-031271826GO:0016616
GeneOntologyMolecularFunctioncalcium-induced calcium release activity

RYR1 RYR2

1.21e-0361822GO:0048763
GeneOntologyMolecularFunctionATP-dependent activity

DNAH3 ABCA2 DNAH10 YTHDC2 CHD4 INO80 ABCA7 ABCC6 UBA7 MYH14 DQX1 ATP6V0A4 DHX35 DNAH11

1.54e-0361418214GO:0140657
GeneOntologyMolecularFunctionoxidoreductase activity, acting on CH-OH group of donors

AKR1C4 H6PD AKR1C1 AKR1C2 AKR1C3 KCNAB3

1.68e-031381826GO:0016614
GeneOntologyMolecularFunctionoxidoreductase activity, acting on NAD(P)H

DUOX2 AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.78e-03951825GO:0016651
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH3 DNAH10 DNAH11

2.06e-03281823GO:0051959
GeneOntologyMolecularFunctionoxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.19e-03601824GO:0016655
GeneOntologyMolecularFunctionchemorepellent activity

SEMA5A SLIT2 SEMA3E

2.29e-03291823GO:0045499
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

DOCK1 ARHGAP15 DOCK10 ARHGAP9 TBC1D8B FARP2 SLIT2 NF1 SRGAP3 ARHGAP12 TNK2 SEC23A

2.44e-0350718212GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

DOCK1 ARHGAP15 DOCK10 ARHGAP9 TBC1D8B FARP2 SLIT2 NF1 SRGAP3 ARHGAP12 TNK2 SEC23A

2.44e-0350718212GO:0030695
GeneOntologyMolecularFunctionATP hydrolysis activity

DNAH3 ABCA2 DNAH10 YTHDC2 CHD4 INO80 ABCA7 ABCC6 DQX1 DHX35 DNAH11

2.46e-0344118211GO:0016887
GeneOntologyMolecularFunctiontestosterone dehydrogenase (NAD+) activity

AKR1C4 AKR1C3

2.85e-0391822GO:0047035
GeneOntologyMolecularFunctionarmadillo repeat domain binding

AXIN1 CNOT1

2.85e-0391822GO:0070016
GeneOntologyMolecularFunctionsyndecan binding

SEMA5A NF1

2.85e-0391822GO:0045545
GeneOntologyMolecularFunctionlncRNA binding

POU1F1 SUZ12 KDM1A

3.93e-03351823GO:0106222
GeneOntologyMolecularFunctionmonooxygenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3 NOS3

4.08e-031151825GO:0004497
GeneOntologyMolecularFunctionGTPase activator activity

DOCK1 ARHGAP15 ARHGAP9 TBC1D8B NF1 SRGAP3 ARHGAP12 SEC23A

4.16e-032791828GO:0005096
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH3 DNAH10 DNAH11

4.61e-03371823GO:0045505
GeneOntologyBiologicalProcessresponse to jasmonic acid

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.00e-0941834GO:0009753
GeneOntologyBiologicalProcessprogesterone catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.00e-0941834GO:0006709
GeneOntologyBiologicalProcessC21-steroid hormone catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.00e-0941834GO:0008208
GeneOntologyBiologicalProcesscellular response to jasmonic acid stimulus

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.00e-0941834GO:0071395
GeneOntologyBiologicalProcesssesquiterpenoid catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.98e-0851834GO:0016107
GeneOntologyBiologicalProcessolefinic compound catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.98e-0851834GO:0120256
GeneOntologyBiologicalProcessfarnesol metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.98e-0851834GO:0016487
GeneOntologyBiologicalProcessfarnesol catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.98e-0851834GO:0016488
GeneOntologyBiologicalProcessnegative regulation of isoprenoid metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.98e-0851834GO:0045827
GeneOntologyBiologicalProcessnegative regulation of retinoic acid biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.98e-0851834GO:1900053
GeneOntologyBiologicalProcesssesquiterpenoid metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.87e-0861834GO:0006714
GeneOntologyBiologicalProcesspolyprenol catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.87e-0861834GO:0016095
GeneOntologyBiologicalProcessresponse to prostaglandin D

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.06e-0771834GO:0071798
GeneOntologyBiologicalProcesscellular response to prostaglandin D stimulus

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.06e-0771834GO:0071799
GeneOntologyBiologicalProcessregulation of retinoic acid biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.06e-0771834GO:1900052
GeneOntologyBiologicalProcessdaunorubicin metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.30e-0791834GO:0044597
GeneOntologyBiologicalProcessregulation of retinoic acid receptor signaling pathway

AKR1C4 AKR1C1 AKR1C2 AKR1C3 CNOT1

9.44e-07211835GO:0048385
GeneOntologyBiologicalProcessregulation of isoprenoid metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.21e-06101834GO:0019747
GeneOntologyBiologicalProcessdoxorubicin metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.21e-06101834GO:0044598
GeneOntologyBiologicalProcessnegative regulation of vitamin metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.21e-06101834GO:0046137
GeneOntologyBiologicalProcesspolyketide metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.21e-06101834GO:0030638
GeneOntologyBiologicalProcessaminoglycoside antibiotic metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.21e-06101834GO:0030647
GeneOntologyBiologicalProcesstertiary alcohol metabolic process

AKR1C4 H6PD AKR1C1 AKR1C2 AKR1C3

1.21e-06221835GO:1902644
GeneOntologyBiologicalProcessregulation of testosterone biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.88e-06111834GO:2000224
GeneOntologyBiologicalProcessterpenoid catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.88e-06111834GO:0016115
GeneOntologyBiologicalProcessregulation of ketone biosynthetic process

AKR1C4 H6PD AKR1C1 AKR1C2 AKR1C3

2.94e-06261835GO:0010566
GeneOntologyBiologicalProcessretinoic acid biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.60e-06141834GO:0002138
GeneOntologyBiologicalProcessisoprenoid catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.60e-06141834GO:0008300
GeneOntologyBiologicalProcessditerpenoid biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-06151834GO:0016102
GeneOntologyBiologicalProcesstestosterone biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.00e-05161834GO:0061370
GeneOntologyBiologicalProcessnegative regulation of hormone metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.00e-05161834GO:0032351
GeneOntologyBiologicalProcesssynapse organization

DOCK1 RELN CTTNBP2 SPTBN2 L1CAM DOCK10 NBEA CHD4 PLXND1 APOE YWHAZ NEFH SLIT2 SRPX2 NF1 HMCN2 SRGAP3 ADGRL2 SEMA3E

1.17e-0568518319GO:0050808
GeneOntologyBiologicalProcesssteroid catabolic process

AKR1C4 APOE AKR1C1 AKR1C2 AKR1C3

1.18e-05341835GO:0006706
GeneOntologyBiologicalProcessolefinic compound biosynthetic process

AKR1C4 H6PD AKR1C1 AKR1C2 AKR1C3

1.36e-05351835GO:0120255
GeneOntologyBiologicalProcessregulation of vitamin metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.66e-05181834GO:0030656
GeneOntologyBiologicalProcesscell junction organization

DOCK1 RELN CTTNBP2 ANK2 SPTBN2 L1CAM DOCK10 NBEA CHD4 ITGA2 PLXND1 APOE YWHAZ NEFH SLIT2 CCM2 SRPX2 NF1 HMCN2 SRGAP3 HRG ADGRL2 SEMA3E

1.84e-0597418323GO:0034330
GeneOntologyBiologicalProcessretinoic acid receptor signaling pathway

AKR1C4 AKR1C1 AKR1C2 AKR1C3 CNOT1

2.06e-05381835GO:0048384
GeneOntologyBiologicalProcesshormone catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.19e-05211834GO:0042447
GeneOntologyBiologicalProcessterpenoid biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.19e-05211834GO:0016114
GeneOntologyBiologicalProcessketone catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.19e-05211834GO:0042182
GeneOntologyBiologicalProcessretinal metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.19e-05211834GO:0042574
GeneOntologyBiologicalProcessglycoside metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.87e-05221834GO:0016137
GeneOntologyBiologicalProcessprogesterone metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.87e-05221834GO:0042448
GeneOntologyBiologicalProcessparturition

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.87e-05221834GO:0007567
GeneOntologyBiologicalProcessregulation of synapse organization

DOCK1 RELN CTTNBP2 L1CAM DOCK10 CHD4 APOE YWHAZ SLIT2 SRPX2 NF1 SRGAP3 ADGRL2

4.42e-0538718313GO:0050807
GeneOntologyBiologicalProcessregulation of steroid biosynthetic process

ABCA2 AKR1C4 H6PD APOE AKR1C1 AKR1C2 AKR1C3

4.49e-051061837GO:0050810
GeneOntologyBiologicalProcesscellular response to prostaglandin stimulus

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.65e-05231834GO:0071379
GeneOntologyBiologicalProcessprimary alcohol catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.65e-05231834GO:0034310
GeneOntologyBiologicalProcessregulation of synapse structure or activity

DOCK1 RELN CTTNBP2 L1CAM DOCK10 CHD4 APOE YWHAZ SLIT2 SRPX2 NF1 SRGAP3 ADGRL2

5.45e-0539518313GO:0050803
GeneOntologyBiologicalProcessalcohol catabolic process

AKR1C4 APOE AKR1C1 AKR1C2 AKR1C3

5.90e-05471835GO:0046164
GeneOntologyBiologicalProcessameboidal-type cell migration

DOCK1 FNDC3B EPPK1 NCKAP1 SEMA5A ITGA2 PLXND1 APOE SLIT2 PTP4A3 SRPX2 NF1 HRG EMP2 NOS3 SEMA3E

5.92e-0557718316GO:0001667
GeneOntologyBiologicalProcessmitochondrial NAD transmembrane transport

SLC25A51 SLC25A52

7.83e-0521832GO:1990549
GeneOntologyBiologicalProcesssmall GTPase-mediated signal transduction

DOCK1 RELN ARHGAP15 NCKAP1 DOCK10 ARHGAP9 SIAH2 APOE RAB6C FARP2 SLIT2 NF1 SRGAP3 ARHGAP12 TNK2

9.54e-0553818315GO:0007264
GeneOntologyBiologicalProcesssemaphorin-plexin signaling pathway

NCAM1 SEMA5A PLXND1 FARP2 SEMA3E

9.65e-05521835GO:0071526
GeneOntologyBiologicalProcesssynapse assembly

DOCK1 RELN SPTBN2 L1CAM DOCK10 CHD4 PLXND1 SLIT2 SRPX2 SRGAP3 ADGRL2

1.01e-0430818311GO:0007416
GeneOntologyBiologicalProcessnegative regulation of mRNA splicing, via spliceosome

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.04e-04281834GO:0048025
GeneOntologyBiologicalProcesspolyprenol metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.20e-04291834GO:0016093
GeneOntologyBiologicalProcessnegative regulation of mRNA processing

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.20e-04291834GO:0050686
GeneOntologyBiologicalProcessepithelial cell migration

DOCK1 EPPK1 SEMA5A ITGA2 PLXND1 APOE SLIT2 PTP4A3 SRPX2 NF1 HRG EMP2 NOS3

1.34e-0443218313GO:0010631
GeneOntologyBiologicalProcessepithelium migration

DOCK1 EPPK1 SEMA5A ITGA2 PLXND1 APOE SLIT2 PTP4A3 SRPX2 NF1 HRG EMP2 NOS3

1.43e-0443518313GO:0090132
GeneOntologyBiologicalProcessketone biosynthetic process

AKR1C4 H6PD AKR1C1 AKR1C2 AKR1C3

1.50e-04571835GO:0042181
GeneOntologyBiologicalProcessdiencephalon development

POU1F1 DUOX2 NCAM1 SEMA5A KDM1A SEMA3E

1.51e-04901836GO:0021536
GeneOntologyBiologicalProcessnegative regulation of lipid biosynthetic process

ABCA2 AKR1C4 APOE AKR1C1 AKR1C2 AKR1C3

1.60e-04911836GO:0051055
GeneOntologyBiologicalProcessregulation of hormone metabolic process

AKR1C4 H6PD AKR1C1 AKR1C2 AKR1C3

1.63e-04581835GO:0032350
GeneOntologyBiologicalProcesstissue migration

DOCK1 EPPK1 SEMA5A ITGA2 PLXND1 APOE SLIT2 PTP4A3 SRPX2 NF1 HRG EMP2 NOS3

1.64e-0444118313GO:0090130
GeneOntologyBiologicalProcessneuron recognition

L1CAM NCAM1 SEMA5A PLXND1 YWHAZ

1.77e-04591835GO:0008038
GeneOntologyBiologicalProcesspositive regulation of endothelial cell apoptotic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.78e-04321834GO:2000353
GeneOntologyBiologicalProcessnegative regulation of RNA splicing

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.01e-04331834GO:0033119
GeneOntologyBiologicalProcessregulation of steroid metabolic process

ABCA2 AKR1C4 H6PD APOE AKR1C1 AKR1C2 AKR1C3

2.06e-041351837GO:0019218
GeneOntologyBiologicalProcesspositive regulation of low-density lipoprotein particle receptor catabolic process

ABCA2 APOE

2.33e-0431832GO:0032805
GeneOntologyBiologicalProcesssynaptic target recognition

PLXND1 YWHAZ

2.33e-0431832GO:0008039
GeneOntologyBiologicalProcessregulation of SA node cell action potential

ANK2 RYR2

2.33e-0431832GO:0098907
GeneOntologyBiologicalProcessregulation of epithelial cell migration

DOCK1 EPPK1 SEMA5A ITGA2 APOE SLIT2 SRPX2 NF1 HRG EMP2 NOS3

2.63e-0434418311GO:0010632
GeneOntologyBiologicalProcessresponse to prostaglandin

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.83e-04361834GO:0034694
GeneOntologyBiologicalProcessisoprenoid biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.83e-04361834GO:0008299
GeneOntologyBiologicalProcessretinoic acid metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.27e-04401834GO:0042573
GeneOntologyBiologicalProcessregulation of synapse assembly

DOCK1 L1CAM DOCK10 CHD4 SLIT2 SRPX2 SRGAP3 ADGRL2

4.57e-042021838GO:0051963
GeneOntologyBiologicalProcessregulation of phospholipid efflux

APOE ABCA7

4.64e-0441832GO:1902994
GeneOntologyBiologicalProcesspositive regulation of phospholipid efflux

APOE ABCA7

4.64e-0441832GO:1902995
GeneOntologyBiologicalProcessregulation of atrial cardiac muscle cell action potential

ANK2 RYR2

4.64e-0441832GO:0098910
GeneOntologyBiologicalProcessorganic hydroxy compound catabolic process

AKR1C4 APOE AKR1C1 AKR1C2 AKR1C3

4.80e-04731835GO:1901616
GeneOntologyBiologicalProcessregulation of endothelial cell apoptotic process

SEMA5A AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.11e-04741835GO:2000351
GeneOntologyBiologicalProcesscellular response to fatty acid

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.16e-04421834GO:0071398
GeneOntologyBiologicalProcessregulation of actin filament-based process

ANK2 NCKAP1 SPTBN2 SEMA5A RICTOR RYR2 SLIT2 RHPN2 RHPN2P1 HRG GRHL3 FCHSD1

5.62e-0443818312GO:0032970
GeneOntologyBiologicalProcesscell junction assembly

DOCK1 RELN ANK2 SPTBN2 L1CAM DOCK10 CHD4 ITGA2 PLXND1 SLIT2 SRPX2 SRGAP3 HRG ADGRL2

5.76e-0456918314GO:0034329
GeneOntologyBiologicalProcessC21-steroid hormone metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.72e-04451834GO:0008207
GeneOntologyBiologicalProcessendothelial cell apoptotic process

SEMA5A AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.90e-04791835GO:0072577
GeneOntologyBiologicalProcesspositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

RELN SEMA5A RICTOR AKR1C4 AKR1C1 AKR1C2 AKR1C3 SEMA3E

7.31e-042171838GO:0051897
GeneOntologyBiologicalProcessregulation of AV node cell action potential

ANK2 RYR2

7.69e-0451832GO:0098904
GeneOntologyBiologicalProcessNAD transmembrane transport

SLC25A51 SLC25A52

7.69e-0451832GO:0035352
GeneOntologyBiologicalProcessendothelial cell migration

SEMA5A PLXND1 APOE SLIT2 PTP4A3 SRPX2 NF1 HRG EMP2 NOS3

7.74e-0433118310GO:0043542
GeneOntologyBiologicalProcesssupramolecular fiber organization

EPPK1 KRT15 NCKAP1 SPTBN2 SIAH1 SEMA5A SIAH2 RICTOR APOE AXIN1 NEFH SLIT2 NF1 RHPN2 ARHGAP12 CST3 RHPN2P1 EMP2 FCHSD1

8.87e-0495718319GO:0097435
GeneOntologyBiologicalProcessaxon guidance

RELN B4GAT1 L1CAM NCAM1 SIAH1 SEMA5A SLIT2 HMCN2 SEMA3E

1.04e-032851839GO:0007411
GeneOntologyBiologicalProcessneuron projection guidance

RELN B4GAT1 L1CAM NCAM1 SIAH1 SEMA5A SLIT2 HMCN2 SEMA3E

1.06e-032861839GO:0097485
GeneOntologyBiologicalProcesscellular response to calcium ion

AKR1C4 AKR1C1 AKR1C2 RYR1 AKR1C3

1.12e-03881835GO:0071277
GeneOntologyBiologicalProcessNAD transport

SLC25A51 SLC25A52

1.15e-0361832GO:0043132
GeneOntologyBiologicalProcessNMDA glutamate receptor clustering

RELN APOE

1.15e-0361832GO:0097114
GeneOntologyBiologicalProcesspositive regulation of reactive oxygen species metabolic process

AKR1C4 AKR1C1 AKR1C2 SYK AKR1C3

1.18e-03891835GO:2000379
GeneOntologyBiologicalProcessactin filament-based process

CTTNBP2 ANK2 NCKAP1 SPTBN2 SEMA5A RICTOR RYR2 FARP2 SLIT2 NF1 RHPN2 MYH14 ARHGAP12 RHPN2P1 HRG EMP2 GRHL3 FCHSD1

1.30e-0391218318GO:0030029
GeneOntologyCellularComponentglutamatergic synapse

DOCK1 CTTNBP2 VPS26B SPTBN2 L1CAM ANKS1B DOCK10 NCAM1 NBEA CHD4 GRIK4 PLXND1 APOE PDE10A YWHAZ NCDN NF1 SRGAP3 ADGRL2

8.45e-0581718019GO:0098978
GeneOntologyCellularComponentcell body

PITPNM2 RELN SPTBN2 L1CAM GLRA3 NCAM1 SIAH2 GRIK4 PLXND1 APOE PDE10A NCDN NEFH SLIT2 HMCN2 CST3 MTNR1A TNK2 WDFY3 FCHSD1

1.55e-0492918020GO:0044297
GeneOntologyCellularComponentneuronal cell body

RELN SPTBN2 L1CAM GLRA3 NCAM1 SIAH2 GRIK4 APOE PDE10A NCDN NEFH SLIT2 HMCN2 CST3 MTNR1A TNK2 WDFY3 FCHSD1

3.30e-0483518018GO:0043025
GeneOntologyCellularComponentsomatodendritic compartment

RELN CTTNBP2 SPTBN2 L1CAM GLRA3 ANKS1B DOCK10 NCAM1 SIAH2 GRIK4 APOE LMTK3 PDE10A NCDN NEFH SLIT2 NF1 HMCN2 CST3 MTNR1A TNK2 WDFY3 FCHSD1

3.72e-04122818023GO:0036477
MousePhenoincreased circulating progesterone level

AKR1C4 AKR1C1 AKR1C2 AKR1C3 NOS3

2.99e-07151445MP:0005186
MousePhenoparturition failure

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.16e-06101444MP:0012010
MousePhenohypermyelination

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.37e-06111444MP:0010050
MousePhenodecreased vocalization

CTTNBP2 ANK2 AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.18e-06461446MP:0020351
MousePhenoincreased oligodendrocyte number

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.18e-06131444MP:0010160
MousePhenoectopic neuron

RELN B4GAT1 ACP2 POU1F1 YWHAZ WDFY3

9.25e-06481446MP:0011723
MousePhenoprolonged diestrus

AKR1C4 AKR1C1 AKR1C2 AKR1C3 NOS3

1.25e-05301445MP:0009011
MousePhenolong stride length

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.35e-05151444MP:0010540
MousePhenolong gestation period

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.35e-05151444MP:0002293
MousePhenoabnormal diestrus

AKR1C4 AKR1C1 AKR1C2 AKR1C3 NOS3

2.74e-05351445MP:0009010
MousePhenoabnormal social/conspecific interaction behavior

RELN CTTNBP2 ANK2 L1CAM BBS1 NBEA AKR1C4 APOE LMTK3 PDE10A AKR1C1 AKR1C2 SRPX2 SRGAP3 AKR1C3

2.91e-0542114415MP:0002557
MousePhenoabnormal gestational length

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.95e-05181444MP:0002292
MousePhenoabnormal vocalization

CTTNBP2 ANK2 INTS7 NOXA1 AKR1C4 INO80 AKR1C1 AKR1C2 ZC3H7A SRPX2 AKR1C3

3.40e-0523714411MP:0001529
MousePhenoenhanced coordination

ABCA2 AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.13e-05381445MP:0003858
MousePhenodysmyelination

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.60e-05201444MP:0013438
MousePhenoprolonged estrous cycle

AKR1C4 AKR1C1 AKR1C2 AKR1C3 NOS3

4.70e-05391445MP:0009006
MousePhenodecreased oligodendrocyte number

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.15e-04251444MP:0009808
MousePhenoabnormal circulating progesterone level

AKR1C4 AKR1C1 AKR1C2 AKR1C3 NOS3

1.58e-04501445MP:0005184
MousePhenoabnormal heart septum morphology

DOCK1 CHD4 PLXND1 RYR1 RYR2 SLIT2 NF1 DHX35 WDFY3 ADGRL2 NOS3 KDM1A DNAH11

1.87e-0438814413MP:0006113
MousePhenoabnormal neurite morphology

SH3TC2 ABCA2 ANK2 ACP2 SPTBN2 L1CAM BBS1 BCL2L2 APOE YWHAZ NEFH SLIT2 KIDINS220 SRGAP3

1.89e-0444214414MP:0008415
MousePhenoincreased stereotypic behavior

ANKS1B AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.09e-04531445MP:0001409
MousePhenoabnormal interventricular septum morphology

DOCK1 CHD4 PLXND1 RYR2 SLIT2 NF1 DHX35 WDFY3 ADGRL2 NOS3 KDM1A DNAH11

2.18e-0434214412MP:0000281
MousePhenoabnormal progesterone level

AKR1C4 AKR1C1 AKR1C2 AKR1C3 NOS3

2.28e-04541445MP:0011384
MousePhenoabnormal tectorial membrane morphology

SLC26A4 POU1F1 DUOX2 APOE

3.10e-04321444MP:0003149
MousePhenorenal glomerulus lipidosis

APOE NOS3

3.14e-0431442MP:0011561
MousePhenoabnormal parturition

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.50e-04331444MP:0002907
MousePhenoventricular septal defect

DOCK1 CHD4 PLXND1 SLIT2 NF1 DHX35 WDFY3 NOS3 KDM1A DNAH11

3.71e-0426114410MP:0010402
MousePhenostereotypic behavior

SLC26A4 ANKS1B AKR1C4 AKR1C1 AKR1C2 AXIN1 ATP6V0A4 AKR1C3 GRHL3

3.73e-042141449MP:0001408
Domain-

AKR1C4 AKR1C1 AKR1C2 AKR1C3 KCNAB3

3.07e-071617953.20.20.100
DomainNADP_OxRdtase_dom

AKR1C4 AKR1C1 AKR1C2 AKR1C3 KCNAB3

4.31e-07171795IPR023210
DomainAldo_ket_red

AKR1C4 AKR1C1 AKR1C2 AKR1C3 KCNAB3

4.31e-07171795PF00248
DomainAldo/ket_red/Kv-b

AKR1C4 AKR1C1 AKR1C2 AKR1C3 KCNAB3

4.31e-07171795IPR001395
DomainALDOKETO_REDUCTASE_1

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.64e-06101794PS00798
DomainALDOKETO_REDUCTASE_2

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.64e-06101794PS00062
DomainALDOKETO_REDUCTASE_3

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.64e-06101794PS00063
DomainAldo/ket_reductase_CS

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.64e-06101794IPR018170
DomainAldo/keto_reductase

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.64e-06101794IPR020471
DomainRho_GTPase_act

ARHGAP15 ARHGAP9 ARHGAP12

3.44e-0641793IPR015767
DomainDUF4704

NBEA WDFY3 LRBA

8.54e-0651793IPR031570
DomainDUF4704

NBEA WDFY3 LRBA

8.54e-0651793PF15787
DomainPH_BEACH

NBEA WDFY3 LRBA

1.70e-0561793PF14844
DomainSH3_1

DOCK1 SH3TC2 AHI1 NOXA1 ARHGAP9 SRGAP3 ARHGAP12 TNK2 FCHSD1

2.96e-051641799PF00018
DomainSH3

DOCK1 SH3TC2 AHI1 NOXA1 ARHGAP9 SRGAP3 ZDHHC6 ARHGAP12 TNK2 FCHSD1

4.58e-0521617910SM00326
DomainPH-BEACH_dom

NBEA WDFY3 LRBA

4.68e-0581793IPR023362
Domain-

NBEA WDFY3 LRBA

4.68e-05817932.30.29.40
DomainPH_BEACH

NBEA WDFY3 LRBA

4.68e-0581793PS51783
DomainSH3_domain

DOCK1 SH3TC2 AHI1 NOXA1 ARHGAP9 SRGAP3 ZDHHC6 ARHGAP12 TNK2 FCHSD1

5.35e-0522017910IPR001452
DomainBEACH

NBEA WDFY3 LRBA

6.97e-0591793PS50197
DomainBeach

NBEA WDFY3 LRBA

6.97e-0591793PF02138
Domain-

NBEA WDFY3 LRBA

6.97e-05917931.10.1540.10
DomainBeach

NBEA WDFY3 LRBA

6.97e-0591793SM01026
DomainBEACH_dom

NBEA WDFY3 LRBA

6.97e-0591793IPR000409
DomainDUF1088

NBEA LRBA

9.13e-0521792IPR010508
DomainDUF1088

NBEA LRBA

9.13e-0521792PF06469
Domain-

ANKRD31 CTTNBP2 ANK2 ANKS1B YTHDC2 RNASEL KIDINS220 ASB5 ASB7 ABTB2

1.44e-04248179101.25.40.20
DomainANK

ANKRD31 CTTNBP2 ANK2 ANKS1B YTHDC2 RNASEL KIDINS220 ASB5 ASB7 ABTB2

1.59e-0425117910SM00248
DomainANK_REPEAT

ANKRD31 CTTNBP2 ANK2 ANKS1B YTHDC2 RNASEL KIDINS220 ASB5 ASB7 ABTB2

1.70e-0425317910PS50088
DomainAnkyrin_rpt-contain_dom

ANKRD31 CTTNBP2 ANK2 ANKS1B YTHDC2 RNASEL KIDINS220 ASB5 ASB7 ABTB2

1.75e-0425417910IPR020683
DomainANK_REP_REGION

ANKRD31 CTTNBP2 ANK2 ANKS1B YTHDC2 RNASEL KIDINS220 ASB5 ASB7 ABTB2

1.75e-0425417910PS50297
DomainRho_GTPase_activation_prot

ARHGAP15 ARHGAP9 PLXND1 NF1 SRGAP3 ARHGAP12

2.02e-04881796IPR008936
DomainAnkyrin_rpt

ANKRD31 CTTNBP2 ANK2 ANKS1B YTHDC2 RNASEL KIDINS220 ASB5 ASB7 ABTB2

2.25e-0426217910IPR002110
DomainAnk_2

ANKRD31 CTTNBP2 ANK2 ANKS1B RNASEL KIDINS220 ASB5 ASB7 ABTB2

2.35e-042151799PF12796
DomainSH3

DOCK1 SH3TC2 AHI1 NOXA1 ARHGAP9 SRGAP3 ARHGAP12 TNK2 FCHSD1

2.43e-042161799PS50002
DomainRyanodine_rcpt

RYR1 RYR2

2.72e-0431792IPR003032
DomainRyanrecept_TM4-6

RYR1 RYR2

2.72e-0431792IPR009460
DomainElf-1_N

ELF1 ELF2

2.72e-0431792PF12310
Domain7-in-absentia-prot_TRAF-dom

SIAH1 SIAH2

2.72e-0431792IPR018121
DomainRyR

RYR1 RYR2

2.72e-0431792PF02026
DomainRR_TM4-6

RYR1 RYR2

2.72e-0431792PF06459
DomainTF_Elf_N

ELF1 ELF2

2.72e-0431792IPR022084
DomainSina

SIAH1 SIAH2

2.72e-0431792PF03145
DomainRyan_recept

RYR1 RYR2

2.72e-0431792IPR013333
DomainDynein_heavy_chain_D4_dom

DNAH3 DNAH10 DNAH11

2.92e-04141793IPR024317
DomainDynein_HC_stalk

DNAH3 DNAH10 DNAH11

2.92e-04141793IPR024743
DomainDynein_heavy_dom-2

DNAH3 DNAH10 DNAH11

2.92e-04141793IPR013602
DomainDHC_N2

DNAH3 DNAH10 DNAH11

2.92e-04141793PF08393
DomainATPase_dyneun-rel_AAA

DNAH3 DNAH10 DNAH11

2.92e-04141793IPR011704
Domain-

SIAH1 SIAH2 MEP1B

2.92e-041417932.60.210.10
DomainMT

DNAH3 DNAH10 DNAH11

2.92e-04141793PF12777
DomainAAA_8

DNAH3 DNAH10 DNAH11

2.92e-04141793PF12780
DomainAAA_5

DNAH3 DNAH10 DNAH11

2.92e-04141793PF07728
DomainDHC_fam

DNAH3 DNAH10 DNAH11

3.62e-04151793IPR026983
DomainDynein_heavy

DNAH3 DNAH10 DNAH11

3.62e-04151793PF03028
DomainDynein_heavy_dom

DNAH3 DNAH10 DNAH11

3.62e-04151793IPR004273
DomainAnk

ANKRD31 CTTNBP2 ANK2 ANKS1B RNASEL KIDINS220 ASB5 ASB7 ABTB2

3.62e-042281799PF00023
DomainDUF1605

YTHDC2 DQX1 DHX35

5.33e-04171793IPR011709
DomainOB_NTP_bind

YTHDC2 DQX1 DHX35

5.33e-04171793PF07717
DomainSINA-like

SIAH1 SIAH2

5.41e-0441792IPR004162
DomainZnf_SIAH

SIAH1 SIAH2

5.41e-0441792IPR013010
DomainHA2

YTHDC2 DQX1 DHX35

6.35e-04181793SM00847
DomainHA2

YTHDC2 DQX1 DHX35

6.35e-04181793PF04408
DomainHelicase-assoc_dom

YTHDC2 DQX1 DHX35

6.35e-04181793IPR007502
DomainZF_SIAH

SIAH1 SIAH2

8.96e-0451792PS51081
DomainTPR_REGION

SH3TC2 DNAH10 NOXA1 TTC27 ZC3H7A FANCG TTC23

1.08e-031651797PS50293
DomainTPR

SH3TC2 DNAH10 NOXA1 TTC27 ZC3H7A FANCG TTC23

1.08e-031651797PS50005
DomainARM-like

INTS7 DOCK10 RICTOR NBEA API5 RANBP17 NF1 WDFY3 LRBA

1.21e-032701799IPR011989
DomainRIH_assoc-dom

RYR1 RYR2

1.34e-0361792IPR013662
DomainIns145_P3_rec

RYR1 RYR2

1.34e-0361792PF08709
DomainRIH_assoc

RYR1 RYR2

1.34e-0361792PF08454
DomainRIH_dom

RYR1 RYR2

1.34e-0361792IPR000699
DomainIns145_P3_rcpt

RYR1 RYR2

1.34e-0361792IPR014821
DomainRyanodine_recept-rel

RYR1 RYR2

1.34e-0361792IPR015925
Domain-

RYR1 RYR2

1.34e-03617921.25.10.30
DomainRYDR_ITPR

RYR1 RYR2

1.34e-0361792PF01365
DomainTRAF-like

SIAH1 SIAH2 MEP1B

1.51e-03241793IPR008974
DomainARM-type_fold

DOCK1 INTS7 RICTOR NBEA API5 NCDN RANBP17 NF1 WDFY3 LRBA

1.64e-0333917910IPR016024
DomainDHC_N1

DNAH10 DNAH11

2.46e-0381792PF08385
DomainDynein_heavy_dom-1

DNAH10 DNAH11

2.46e-0381792IPR013594
DomainAAA

DNAH3 ABCA2 DNAH10 ABCA7 ABCC6 DNAH11

2.67e-031441796SM00382
DomainAAA+_ATPase

DNAH3 ABCA2 DNAH10 ABCA7 ABCC6 DNAH11

2.67e-031441796IPR003593
DomainPH_dom-like

ARHGAP15 SPTBN2 ANKS1B DOCK10 ARHGAP9 NBEA FARP2 CCM2 ARHGAP12 WDFY3 LRBA

2.76e-0342617911IPR011993
DomainRhoGAP

ARHGAP15 ARHGAP9 SRGAP3 ARHGAP12

2.95e-03621794SM00324
DomainRhoGAP

ARHGAP15 ARHGAP9 SRGAP3 ARHGAP12

3.13e-03631794PF00620
DomainSemap_dom

SEMA5A PLXND1 SEMA3E

3.19e-03311793IPR001627
DomainSEMA

SEMA5A PLXND1 SEMA3E

3.19e-03311793PS51004
DomainSema

SEMA5A PLXND1 SEMA3E

3.19e-03311793SM00630
DomainSema

SEMA5A PLXND1 SEMA3E

3.19e-03311793PF01403
DomainRhoGAP_dom

ARHGAP15 ARHGAP9 SRGAP3 ARHGAP12

3.31e-03641794IPR000198
DomainRHOGAP

ARHGAP15 ARHGAP9 SRGAP3 ARHGAP12

3.31e-03641794PS50238
Domain-

ARHGAP15 ARHGAP9 SRGAP3 ARHGAP12

3.31e-036417941.10.555.10
DomainHelicase_C

YTHDC2 CHD4 INO80 DQX1 DHX35

3.85e-031081795IPR001650
DomainMIR

RYR1 RYR2

3.91e-03101792PF02815
DomainMIR_motif

RYR1 RYR2

3.91e-03101792IPR016093
DomainMIR

RYR1 RYR2

3.91e-03101792PS50919
DomainMIR

RYR1 RYR2

3.91e-03101792SM00472
DomainHELICASE_CTER

YTHDC2 CHD4 INO80 DQX1 DHX35

4.00e-031091795PS51194
DomainHELICASE_ATP_BIND_1

YTHDC2 CHD4 INO80 DQX1 DHX35

4.00e-031091795PS51192
DomainDEXDc

YTHDC2 CHD4 INO80 DQX1 DHX35

4.00e-031091795SM00487
PathwayWP_BENZOAPYRENE_METABOLISM

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.04e-0691374M39344
PathwayKEGG_MEDICUS_ENV_FACTOR_METALS_TO_KEAP1_NRF2_SIGNALIG_PATHWAY

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.04e-0691374M47817
PathwayKEGG_MEDICUS_ENV_FACTOR_BENZO_A_PYRENRE_TO_CYP_MEDIATED_METABOLISM

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.67e-06111374M47812
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.70e-06131374M17842
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.70e-06131374MM14747
PathwayWP_GLUCOCORTICOID_BIOSYNTHESIS

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.92e-06141374M46449
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.92e-06141374M27074
PathwayWP_MINERALOCORTICOID_BIOSYNTHESIS

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.92e-06141374M46453
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.92e-06141374MM14748
PathwayREACTOME_SYNTHESIS_OF_PROSTAGLANDINS_PG_AND_THROMBOXANES_TX

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.07e-05151374MM14870
PathwayREACTOME_RAC1_GTPASE_CYCLE

DOCK1 ARHGAP15 NCKAP1 NOXA1 DOCK10 ARHGAP9 FARP2 SRGAP3 ARHGAP12

5.24e-051751379MM15599
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.55e-05231374M1926
PathwayREACTOME_PREDNISONE_ADME

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.55e-05231374MM16639
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.55e-05231374MM14741
PathwayREACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS

AKR1C4 APOE AKR1C1 AKR1C2 AKR1C3

7.20e-05451375MM15344
PathwayREACTOME_RAC1_GTPASE_CYCLE

DOCK1 ARHGAP15 NCKAP1 NOXA1 DOCK10 ARHGAP9 FARP2 SRGAP3 ARHGAP12

7.72e-051841379M41809
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

DOCK1 RELN ANK2 SPTBN2 L1CAM NCAM1 SIAH1 SEMA5A SIAH2 ITGA2 PLXND1 FARP2 SLIT2 MYH14 SRGAP3 SEMA3E

1.45e-0457513716M29853
PathwayREACTOME_RA_BIOSYNTHESIS_PATHWAY

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.46e-04281374MM15188
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.81e-04331374M5967
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.81e-04331374MM14737
PathwayREACTOME_OTHER_SEMAPHORIN_INTERACTIONS

SEMA5A PLXND1 SEMA3E

3.02e-04141373MM15047
PathwayREACTOME_SEMAPHORIN_INTERACTIONS

SEMA5A PLXND1 FARP2 MYH14 SEMA3E

3.88e-04641375M7923
PathwayREACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS

SHMT1 AKR1C4 APOE NFS1 AKR1C1 AKR1C2 AKR1C3 NOS3

5.16e-041891378MM14772
PathwayREACTOME_OTHER_SEMAPHORIN_INTERACTIONS

SEMA5A PLXND1 SEMA3E

7.76e-04191373M10959
PathwayREACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.57e-04441374M499
PathwayREACTOME_NETRIN_1_SIGNALING

DOCK1 SIAH1 SIAH2 SLIT2

8.57e-04441374M875
PathwayREACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.34e-04451374MM14751
Pubmed

The Steroidogenic Enzyme AKR1C3 Regulates Stability of the Ubiquitin Ligase Siah2 in Prostate Cancer Cells.

SIAH2 AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.17e-117184526160177
Pubmed

Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to human chromosome bands 10p15-->p14 and mouse chromosome 13 region A2 by in situ hybridization: identification of a new syntenic relationship.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184410393440
Pubmed

Mouse Akr1cl gene product is a prostaglandin D2 11-ketoreductase with strict substrate specificity.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184431479646
Pubmed

Identification of an interleukin-3-regulated aldoketo reductase gene in myeloid cells which may function in autocrine regulation of myelopoiesis.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184410702227
Pubmed

Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184417442338
Pubmed

Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184428329705
Pubmed

Crystallization and preliminary X-ray diffraction analysis of mouse 3(17)alpha-hydroxysteroid dehydrogenase.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184416511129
Pubmed

Characterization and functional analysis of the 5'-flanking region of the mouse 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184415222881
Pubmed

Cloning and characterization of two novel aldo-keto reductases (AKR1C12 and AKR1C13) from mouse stomach.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184410526179
Pubmed

Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184421521174
Pubmed

Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-10418448274401
Pubmed

Identification of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of rat Leydig cells as type II retinol dehydrogenase.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184410803568
Pubmed

AKR1C1 alleviates LPS‑induced ALI in mice by activating the JAK2/STAT3 signaling pathway.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184434590152
Pubmed

Structure and activity of the murine type 5 17beta-hydroxysteroid dehydrogenase gene(1).

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184410500239
Pubmed

AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184419487289
Pubmed

Cloning and chromosomal localization of mouse 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184414967952
Pubmed

Localization of 20alpha-hydroxysteroid dehydrogenase mRNA in mouse brain by in situ hybridization.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184415193432
Pubmed

Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184416191478
Pubmed

Characterization of two isoforms of mouse 3(17)alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase family.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184415577209
Pubmed

Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184417034817
Pubmed

RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184429764944
Pubmed

Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184417888864
Pubmed

Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184419237748
Pubmed

Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184428259989
Pubmed

Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-10418447789999
Pubmed

Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184420124700
Pubmed

Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184416508162
Pubmed

Several distinct enzymes catalyze 20alpha-hydroxysteroid dehydrogenase activity in mouse liver and kidney.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184417629694
Pubmed

Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17alpha-HSD) and its involvement in the biosynthesis of epitestosterone.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184416018803
Pubmed

Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184417272929
Pubmed

Involvement of 20alpha-hydroxysteroid dehydrogenase in the maintenance of pregnancy in mice.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-104184418667791
Pubmed

Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.78e-09518447737980
Pubmed

Pregnane X receptor (PXR) deficiency promotes hepatocarcinogenesis via induction of Akr1c18 expression and prostaglandin F2α (PGF2α) levels.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.78e-095184438788959
Pubmed

Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.78e-095184418003893
Pubmed

Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.78e-095184421851338
Pubmed

Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.78e-095184416984997
Pubmed

Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.78e-095184417872381
Pubmed

Mouse 3alpha-hydroxysteroid dehydrogenase mRNA: a marker of lung maturity.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.78e-095184417064890
Pubmed

Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.78e-095184410672042
Pubmed

The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion.

SIAH1 AKR1C4 APOE AKR1C1 AKR1C2 AKR1C3

6.91e-0928184629212953
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

DMXL2 CTTNBP2 ANK2 NCKAP1 SPTBN2 ANKS1B NCAM1 NBEA CHD4 LMTK3 YWHAZ NCDN RCOR2 NEFH RCOR1 NF1 SRGAP3 ELAVL3 WDFY3 CNOT1 KDM1A SEC23A

9.88e-099631842228671696
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

PITPNM2 DMXL2 CTTNBP2 ANK2 NCKAP1 SPTBN2 L1CAM COX6C ANKS1B NCAM1 YTHDC2 NBEA ITGA2 APOE YWHAZ NCDN NEFH KIDINS220 NF1 MYH14 SRGAP3 HRG ELAVL3 SLC25A11 CNOT1 SEC23A DNAH11

1.05e-0814311842737142655
Pubmed

Expression analysis of the aldo-keto reductases involved in the novel biosynthetic pathway of tetrahydrobiopterin in human and mouse tissues.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.13e-086184419273550
Pubmed

Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.13e-086184415471942
Pubmed

MEF2 and NR2F2 cooperate to regulate Akr1c14 gene expression in mouse MA-10 Leydig cells.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.13e-086184426748576
Pubmed

Adrenal 20alpha-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.13e-086184417122075
Pubmed

The Gαq/11-provoked induction of Akr1c18 in murine luteal cells is mediated by phospholipase C.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.13e-086184429107092
Pubmed

Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.13e-086184415860270
Pubmed

Decidual prolactin silences the expression of genes detrimental to pregnancy.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.13e-086184417255200
Pubmed

A phosphodiesterase 11 (Pde11a) knockout mouse expressed functional but reduced Pde11a: Phenotype and impact on adrenocortical function.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.62e-087184433127481
Pubmed

A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.62e-087184412562828
Pubmed

MicroRNA-200a serves a key role in the decline of progesterone receptor function leading to term and preterm labor.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.62e-087184422529366
Pubmed

Aldo-ketoreductase 1c19 ablation does not affect insulin secretion in murine islets.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.62e-087184434843575
Pubmed

17Beta-HSD type 5 expression and the emergence of differentiated epithelial Type II cells in fetal lung: a novel role for androgen during the surge of surfactant.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.62e-087184416337335
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

PITPNM2 DMXL2 ANK2 NCKAP1 SPTBN2 ANKS1B NCAM1 NBEA YWHAZ NCDN NF1 SRGAP3

3.89e-082811841228706196
Pubmed

Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.22e-088184420837989
Pubmed

Androgen Receptor Is Dispensable for X-Zone Regression in the Female Adrenal but Regulates Post-Partum Corticosterone Levels and Protects Cortex Integrity.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.22e-088184433584538
Pubmed

Cloning of mouse 17beta-hydroxysteroid dehydrogenase type 2, and analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in mouse embryos and adult tissues.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.22e-08818449224647
Pubmed

Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues.

CADM3 L1CAM NCAM1 APOE PDE10A YWHAZ

9.05e-0842184615146195
Pubmed

Decrease in the T-box1 gene expression in embryonic brain and adult hippocampus of down syndrome mouse models.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.36e-089184433348080
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

DMXL2 CTTNBP2 ANK2 NCKAP1 SPTBN2 ANKS1B NCAM1 NBEA YWHAZ NCDN NEFH

1.12e-072511841127507650
Pubmed

Aldo-keto reductase 1C subfamily genes in skin are UV-inducible: possible role in keratinocytes survival.

AKR1C1 AKR1C2 AKR1C3

1.46e-073184319320734
Pubmed

Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1).

RCOR2 RCOR1 KDM1A

1.46e-073184321876670
Pubmed

Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis.

AKR1C1 AKR1C2 AKR1C3

1.46e-073184321232532
Pubmed

Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis.

AKR1C1 AKR1C2 AKR1C3

1.46e-073184331780644
Pubmed

Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes.

AKR1C1 AKR1C2 AKR1C3

1.46e-073184313678667
Pubmed

Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans.

AKR1C4 AKR1C1 AKR1C3

1.46e-07318437626489
Pubmed

Lack of placental neurosteroid alters cortical development and female somatosensory function.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.55e-0710184436313771
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

DMXL2 RELN ABCA2 VSNL1 ANK2 B4GAT1 SPTBN2 RTL10 ANKS1B TTC27 SIAH1 NBEA CHD4 APOE CFAP298 YWHAZ UBA7 MYH14 AKR1C3 DHX35 WDFY3 LRBA KLHL4

3.63e-0712851842335914814
Pubmed

Endogenous biotin as a marker of adrenocortical cells with steroidogenic potential.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.63e-0712184421256921
Pubmed

Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.63e-0712184428893949
Pubmed

A Novel Population of Inner Cortical Cells in the Adrenal Gland That Displays Sexually Dimorphic Expression of Thyroid Hormone Receptor-β1.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.63e-0712184425774556
Pubmed

The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.22e-0713184411682476
Pubmed

Ontogeny of adrenal-like glucocorticoid synthesis pathway and of 20α-hydroxysteroid dehydrogenase in the mouse lung.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.22e-0713184424580729
Pubmed

A link between lung androgen metabolism and the emergence of mature epithelial type II cells.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.22e-0713184415117747
Pubmed

Genetic determinants modulate susceptibility to pregnancy-associated tumourigenesis in a recombinant line of Min mice.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.22e-0713184417062636
Pubmed

SFMBT1 functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors.

RCOR2 RCOR1 KDM1A

5.80e-074184323592795
Pubmed

The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis.

PTP4A1 CNNM3 PTP4A3

5.80e-074184324632616
Pubmed

Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.28e-0714184419955443
Pubmed

Placental endocrine function shapes cerebellar development and social behavior.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.28e-0714184434400844
Pubmed

CoREST/LSD1 control the development of pyramidal cortical neurons.

RCOR2 RCOR1 KDM1A

1.45e-065184321878487
Pubmed

Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma.

AKR1C1 AKR1C2 AKR1C3

1.45e-065184315212687
Pubmed

Mutations in the Reelin pathway are associated with abnormal expression of microglial IgG FC receptors in the cerebellar cortex.

RELN ACP2 APOE

1.45e-065184332594343
Pubmed

The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation.

SIAH1 SIAH2 AXIN1

1.45e-065184328546513
Pubmed

Neuroimmune guidance cue Semaphorin 3E is expressed in atherosclerotic plaques and regulates macrophage retention.

PLXND1 APOE SEMA3E

1.45e-065184323430613
Pubmed

An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells.

AKR1C4 APOE AKR1C1 AKR1C2 AKR1C3

1.49e-0637184521362171
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

PITPNM2 INTS7 YTHDC2 ACAD10 INO80 LMTK3 YWHAZ SLIT2 CCM2 NF1 ARHGAP12 ELAVL3 SLC25A11

1.70e-064751841331040226
Pubmed

Targeted Disruption of Lats1 and Lats2 in Mice Impairs Adrenal Cortex Development and Alters Adrenocortical Cell Fate.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.71e-0617184432243503
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PITPNM2 ABCA2 EPPK1 L1CAM SIAH2 PIGG PLXND1 INO80 LARS2 ABCA7 RYR1 CLCN7 KCNG1 TNK2 TNFAIP2 WDFY3 UBE3C LRBA ABTB2 HOXB13

1.88e-0611051842035748872
Pubmed

LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis.

CHD4 RCOR2 RCOR1 KDM1A

2.19e-0618184419497860
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

FNDC3B DMXL2 NOL6 DOCK10 RICTOR YTHDC2 FHIP2A MAP3K6 NCDN FAM111B FARP2 RHPN2 SLC25A11 TNFAIP2 SEMA3E

2.20e-066501841538777146
Pubmed

Functional dynamics of H3K9 methylation during meiotic prophase progression.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.76e-0619184417599069
Pubmed

The chromatin modifying complex CoREST/LSD1 negatively regulates notch pathway during cerebral cortex development.

RCOR2 RCOR1 KDM1A

2.88e-066184327112428
Pubmed

SIAH ubiquitin ligases target the nonreceptor tyrosine kinase ACK1 for ubiquitinylation and proteasomal degradation.

SIAH1 SIAH2 TNK2

2.88e-066184323208506
Pubmed

Antagonistic actions of Rcor proteins regulate LSD1 activity and cellular differentiation.

RCOR2 RCOR1 KDM1A

2.88e-066184324843136
Pubmed

Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A.

RCOR2 RCOR1 KDM1A

2.88e-066184323576758
Pubmed

A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.44e-0620184423636947
Pubmed

WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.44e-0620184424135228
Pubmed

USP45 and Spindly are part of the same complex implicated in cell migration.

DOCK1 EPPK1 CTTNBP2 ARHGAP9 PLXND1 MYH14 MRPS2 SNRPD3 KCNAB3

4.94e-06235184930258100
Pubmed

Genetic variation in the progesterone receptor and metabolism pathways and hormone therapy in relation to breast cancer risk.

AKR1C1 AKR1C2 AKR1C3

5.02e-067184319846565
InteractionAKR1C4 interactions

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.38e-0781824int:AKR1C4
Cytoband10p15-p14

AKR1C1 AKR1C2 AKR1C3

1.26e-066184310p15-p14
Cytoband13q13

NBEA ELF1

1.59e-045184213q13
CytobandEnsembl 112 genes in cytogenetic band chr10p15

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.88e-04901844chr10p15
GeneFamilyAldo-keto reductases

AKR1C4 AKR1C1 AKR1C2 AKR1C3 KCNAB3

5.24e-08151315399
GeneFamilyWD repeat domain containing|BEACH domain containing

NBEA WDFY3 LRBA

3.02e-05913131230
GeneFamilyAnkyrin repeat domain containing

ANKRD31 CTTNBP2 ANK2 ANKS1B RNASEL KIDINS220 ASB5 ASB7 ABTB2

6.81e-052421319403
GeneFamilyProtein tyrosine phosphatases type IVA

PTP4A1 PTP4A3

1.56e-0431312899
GeneFamilyRyanodine receptors|Protein phosphatase 1 regulatory subunits

RYR1 RYR2

1.56e-0431312287
GeneFamilyDyneins, axonemal

DNAH3 DNAH10 DNAH11

2.35e-04171313536
GeneFamilyRho GTPase activating proteins|BCH domain containing

ARHGAP15 ARHGAP9 SRGAP3 ARHGAP12

4.68e-04501314721
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_C_DN

AHI1 AKR1C4 AKR1C1 AKR1C2 AKR1C3 KLHL4

1.75e-08251846MM480
CoexpressionRAY_TUMORIGENESIS_BY_ERBB2_CDC25A_UP

ABCA2 NCAM1 NBEA CDHR5 AKR1C4 AKR1C1 AKR1C2 SLIT2 RCOR1 AKR1C3

3.64e-0621918410MM1237
CoexpressionIRITANI_MAD1_TARGETS_UP

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.21e-06171844MM826
CoexpressionMCBRYAN_PUBERTAL_BREAST_5_6WK_UP

TLCD4 SIAH2 AKR1C4 CFAP298 AKR1C1 AKR1C2 AKR1C3 ELF1

8.03e-061431848MM989
CoexpressionLIN_TUMOR_ESCAPE_FROM_IMMUNE_ATTACK

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.24e-05241844MM766
CoexpressionBLANCO_MELO_BRONCHIAL_EPITHELIAL_CELLS_INFLUENZA_A_INFECTION_DN

NOXA1 LMTK3 RCOR2 FAM111B EMP2 GRHL3

2.31e-05811846M34025
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

CADM3 RELN VSNL1 ANK2 L1CAM ANKS1B NCAM1 RICTOR NBEA AKR1C1 AKR1C2 NCDN PXK RCOR2 RYR2 FSIP2 SRGAP3 ELAVL3 TNK2 C2CD6 SEMA3E

3.54e-05110618421M39071
CoexpressionIVANOVA_HEMATOPOIESIS_STEM_CELL_LONG_TERM

ANKS1B NBEA AKR1C4 AKR1C1 AKR1C2 C9orf152 SRGAP3 AKR1C3 AK1

3.56e-052281849MM1014
CoexpressionGSE7218_IGM_VS_IGG_SIGNAL_THGOUGH_ANTIGEN_BCELL_UP

DOCK1 INTS7 L1CAM NOL6 NBEA PLXND1 DPP8 SLC30A9

5.54e-051871848M6807
CoexpressionBYSTRYKH_HEMATOPOIESIS_STEM_CELL_SCP2_QTL_TRANS

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.58e-05301844MM853
CoexpressionEIF4E_DN

DOCK1 FNDC3B FHIP2A UBA7 WDFY3 LRBA

7.61e-051001846M2790
CoexpressionFOSTER_KDM1A_TARGETS_UP

RELN ANK2 SLC26A4 SPTBN2 AKR1C4 H6PD AKR1C1 AKR1C2 AKR1C3 ERICH6

8.71e-0531718410MM956
CoexpressionGSE15750_WT_VS_TRAF6KO_DAY6_EFF_CD8_TCELL_DN

CTTNBP2 NBEA ITIH2 C9orf152 HRG ELF2 SUZ12 GRHL3

8.87e-052001848M3571
CoexpressionGSE21379_TFH_VS_NON_TFH_SAP_KO_CD4_TCELL_UP

SH3TC2 NFS1 TBC1D8B STRADB TNK2 TNFAIP2 WDFY3 HOXB13

8.87e-052001848M7516
CoexpressionGSE5679_PPARG_LIGAND_ROSIGLITAZONE_VS_RARA_AGONIST_AM580_TREATED_DC_DN

DOCK10 FHIP2A RYR1 CCM2 RNASEL CCDC87 TNK2 ELF1

8.87e-052001848M6563
CoexpressionDESCARTES_ORGANOGENESIS_INTERMEDIATE_MESODERM

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.16e-04361844MM3660
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HNBML5

VSNL1 ANK2 L1CAM ANKS1B NCAM1 NBEA LMTK3 AKR1C1 NCDN RCOR2 RYR2 ELAVL3

1.18e-0446518412M39066
CoexpressionGOLDRATH_IMMUNE_MEMORY

NCKAP1 AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.26e-04691845MM621
CoexpressionWOOD_EBV_EBNA1_TARGETS_UP

NCKAP1 AKR1C1 AKR1C2 NEFH AKR1C3 EMP2

1.29e-041101846M1696
CoexpressionWANG_IMMORTALIZED_BY_HOXA9_AND_MEIS1_UP

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.30e-04371844MM630
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

CADM3 VSNL1 ANK2 L1CAM NBEA AKR1C1 AKR1C2 KIDINS220 ELAVL3

1.45e-0719918395de2a32bc2e9c752eb19a013b1807949153728fc
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal-neurons_B|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CADM3 ANK2 SPTBN2 L1CAM ANKS1B GRIK4 ELAVL3 LIX1

6.98e-0717618383c78dee7e1111a579fde6d401b9ecb4d5b8e782f
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CADM3 ANK2 SPTBN2 L1CAM ANKS1B GRIK4 ELAVL3 LIX1

6.98e-071761838bfea433544c6d6b8ad55e50ca94c5574460c2e0b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC26A4 SPTBN2 PXK SLIT2 SRGAP3 ATP6V0A4 SYK ABTB2

1.02e-0618518383d73b3e0bceb192257e5cfbe64b7ccb379b6e22d
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CADM3 NCAM1 SEMA5A AKR1C1 AKR1C3 TNK2 EMP2 SEMA3E

1.24e-0619018386c7e1086c0a274cd5527c3104106e372811c9905
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC26A4 SPTBN2 APOE PXK SLIT2 PTP4A3 ATP6V0A4 MINDY1

1.29e-061911838feec8617678b778475747ad406c80231e07fd6f7
ToppCellSevere_COVID-19-Epithelial-transitional_Epi|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

EPPK1 KRT15 NCKAP1 ITGA2 LMTK3 AKR1C1 SRPX2 MYH14

1.63e-0619718385ad3cd4c77016e862041baac3076f8cc0f75c417
ToppCellBAL-Severe-Epithelial-Epithelial-transitional_Epi-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

EPPK1 KRT15 NCKAP1 ITGA2 LMTK3 AKR1C1 SRPX2 MYH14

1.63e-06197183808b371309cd790b171ed76cabc7d910e71cd2835
ToppCellBAL-Severe-Epithelial-Epithelial-transitional_Epi|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

EPPK1 KRT15 NCKAP1 ITGA2 LMTK3 AKR1C1 SRPX2 MYH14

1.63e-0619718389f49feee38647bbf964974aac96fa75602186b5c
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

FNDC3B AHI1 ANK2 SEMA5A APOE RYR2 SLIT2 TNFAIP2

1.75e-0619918388b86c69aaf60feff53aa782559cfece7342a23de
ToppCellNS-moderate-d_07-13-Epithelial|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DUOX2 ITGA2 AKR1C1 AKR1C2 MYH14 AKR1C3 AK1 EMP2

1.82e-06200183885940b4bf7971b872469dea8b8d7a45bdeb2a909
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-Neuronal|GW26 / Sample Type, Dataset, Time_group, and Cell type.

L1CAM NBEA AKR1C1 AKR1C2 NCDN SLIT2 KIDINS220 ELAVL3

1.82e-062001838306926cb7a847871641f02e03d52dc56fd55711c
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Neuronal|5w / Sample Type, Dataset, Time_group, and Cell type.

RELN L1CAM NCAM1 AKR1C1 AKR1C2 KIDINS220 ELAVL3 AK1

1.82e-0620018389b5753726c17dda98d7384a60f26a5eaf4f6c4d6
ToppCellBrain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Cortical_neuron|3m / Sample Type, Dataset, Time_group, and Cell type.

CADM3 CTTNBP2 ANK2 L1CAM NCAM1 NBEA KIDINS220 ELAVL3

1.82e-062001838c248233b004f8ef0bab3c65ecfe295887966f2ee
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HYAL4 SPTBN2 SLIT2 SRGAP3 ATP6V0A4 SYK ABTB2

2.47e-061461837e887e9de895fd453faa703997ef372cc6410fc49
ToppCelldroplet-Marrow-nan-18m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CADM3 L1CAM APOE RYR1 KIDINS220 CST3 CYB561

4.72e-0616118373f3a2148c8d65e6a06f8d8116a3aa58dda17d618
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|kidney / Disease (COVID-19 only), tissue and cell type

DNAH3 RELN ARHGAP15 GLRA3 GRIK4 RYR1 RYR2

5.12e-06163183719c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCell5'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT15 SEMA5A ITGA2 LMTK3 AKR1C1 RHPN2 SRGAP3

5.33e-0616418378d1d0424943d3e98c8b6399dbf702e0035d0db7b
ToppCellRA-01._Fibroblast_I|RA / Chamber and Cluster_Paper

DUOX2 AKR1C1 AKR1C2 SLIT2 SRPX2 SIGLEC11 ABTB2

6.50e-0616918376373562ab3b1765060212a6a53d6543e7e942e80
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell-Papillary_Tip_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DUOX2 AKR1C2 MYH14 DQX1 EMP2 GRHL3 SEMA3E

7.02e-06171183759b9dbaa05b6e5740edc633c9ce1181565550d5b
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DUOX2 AKR1C2 MYH14 DQX1 EMP2 GRHL3 SEMA3E

7.02e-061711837a5b9dd2b6a54db7962beeb5a9ceb9dacfb613fa7
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC26A4 SPTBN2 DOCK10 PXK SLIT2 ATP6V0A4 SYK

8.47e-06176183725ebc8716aa44e44fce577701e3e82c6745a75ab
ToppCellASK428-Epithelial-Secretory|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

VSNL1 KRT15 TLR7 SLC25A51 SRPX2 SRGAP3 C2CD6

8.79e-06177183766074a288501c136b4e83b883db5f0d8269ee326
ToppCell10x5'-lymph-node_spleen-Myeloid_Mac-Intestinal_macrophages|lymph-node_spleen / Manually curated celltypes from each tissue

DMXL2 CTTNBP2 APOE CST3 SIGLEC11 TNFAIP2 WDFY3

9.80e-0618018377be7d7a6906fff6dbdecd9cb013d855aba4eda2a
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CADM3 RELN VSNL1 SPTBN2 ARHGAP9 KCNK12 RYR1

9.80e-0618018376ac62bf1251978c8c12e715f7b73144fca619794
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-4|TCGA-Thryoid / Sample_Type by Project: Shred V9

CTTNBP2 NCKAP1 SPTBN2 PABPC4L AXIN1 FAM111B MYH14

1.13e-051841837d9659d1e4465fec68f48a22edef443f354f6c7cf
ToppCellfacs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RELN POU1F1 DUOX2 RCOR2 DHX35 NOS3 KLHL4

1.17e-05185183759acaf025353405948dc34ccccf37ec5c08ea903
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK1 SH3TC2 ABCA2 DOCK10 ITGA2 PXK ABTB2

1.17e-0518518371d731d69d8db8aef4a11439b8abd1030c7e6ac4c
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK1 SH3TC2 ABCA2 DOCK10 ITGA2 PXK ABTB2

1.17e-051851837b8d02c9426740ffcb69d2e6f95473b388149d297
ToppCelldroplet-Kidney-nan-21m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

L1CAM COX6C RYR2 SLIT2 ELAVL3 AK1 LRBA

1.21e-0518618378eafd4bea692f7ef33de27dd53f9d1fe67deaad8
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK1 SH3TC2 ABCA2 DOCK10 ITGA2 PXK ABTB2

1.30e-05188183714072d0b82df55711d5356b2209f4f0bdd90dc27
ToppCellCOVID-19-Epithelial-Ionocytes|COVID-19 / Condition, Lineage and Cell class

CTTNBP2 ANK2 SPTBN2 NCAM1 SEMA5A C9orf152 ATP6V0A4

1.30e-051881837a581cb9528d0febbf3addbb4f6bc140f91a584e6
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK1 SH3TC2 ABCA2 DOCK10 ITGA2 PXK ABTB2

1.35e-051891837b60c8a29d3169c4830fe63b01db90c57660fc239
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Gpr149_Islr|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NEFH SLIT2 SRPX2 MYH14 GRHL3 KCNAB3

1.37e-0512618363539a8fdbb52d191f36dce68c38798ad4d2b491a
ToppCellBL-critical-LOC-Epithelial-Secretory|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CTTNBP2 SPTBN2 LMTK3 AKR1C1 AKR1C2 SRPX2 EMP2

1.39e-051901837f2abe4bc28e934287e2dcd7b9399d5af78c5c8cf
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-Capillary_Aerocyte_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCAM1 ITGA2 MAP3K6 PTP4A3 EMP2 ADGRL2 DNAH11

1.44e-051911837df8cdbc26443e55a203cbafa21b0952a2a55b9bf
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CTTNBP2 GRIK4 RYR2 SLIT2 SRPX2 ADGRL2 SEMA3E

1.44e-051911837fa380a8752de158974b2ae5e741573439719cc0d
ToppCellLV-01._Fibroblast_I|LV / Chamber and Cluster_Paper

FNDC3B ANKS1B AKR1C1 AKR1C2 SLIT2 SRPX2 ABTB2

1.54e-051931837dc17f3b9758936d428cf17f77a1ce6d4c479b165
ToppCellRV-02._Fibroblast_II|RV / Chamber and Cluster_Paper

FNDC3B ANKS1B PDE10A AKR1C1 SLIT2 SRPX2 ABTB2

1.59e-05194183711c79a8c56ece42713b04b321982e41e239f07a5
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC26A4 COX6C APOE PXK SLIT2 ATP6V0A4 MINDY1

1.59e-0519418376165c00ec06a8393f23b0c62f679c143839b03b1
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA2 ANK2 ANKS1B NCAM1 PDE10A LARS2 ELAVL3

1.59e-051941837ba529c051f248d29f4222f4bc9801ba233859093
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPTBN2 L1CAM NBEA ITGA2 MYH14 EMP2 ABTB2

1.59e-0519418374579b4a44f7c731553a284843c296866027d7c0e
ToppCellLV-02._Fibroblast_II|LV / Chamber and Cluster_Paper

FNDC3B APOE AKR1C1 SLIT2 SRPX2 CST3 ABTB2

1.59e-051941837014d2feb5db2a6a35ef759761a41e466e108c3c1
ToppCell3'-Child04-06-SmallIntestine-Neuronal|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CADM3 RELN ANK2 ARHGAP15 L1CAM NCAM1 EMP2

1.65e-0519518378d286622f86c844d1b06a106ee4a3f813eba05bb
ToppCell3'-Child04-06-SmallIntestine-Neuronal-Glial_mature-Adult_Glia|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CADM3 RELN ANK2 ARHGAP15 L1CAM NCAM1 EMP2

1.65e-051951837359b9d791e26844675c3c60cf69d8ab69c2cf400
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPTBN2 L1CAM NBEA ITGA2 MYH14 EMP2 ABTB2

1.65e-0519518373d6d3de8ada6dce3dc789c15b50cc066e7100496
ToppCell3'-Child04-06-SmallIntestine-Neuronal-Glial_mature|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CADM3 RELN ANK2 ARHGAP15 L1CAM NCAM1 EMP2

1.65e-0519518374193e58788e90c3d1049ef5cf9800a8c4d8ac354
ToppCellBAL-Severe-Epithelial-Epithelial-transitional_Epi|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KRT15 NCKAP1 ITGA2 LMTK3 AKR1C1 SRPX2 MYH14

1.70e-0519618373e99a367b7d817e1f1221450fcec20ad7a7c7a2a
ToppCellBAL-Severe-Epithelial-Epithelial-transitional_Epi-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KRT15 NCKAP1 ITGA2 LMTK3 AKR1C1 SRPX2 MYH14

1.70e-0519618371efacc37bbfbd05b5d4db3dd10f6d9a238d23e31
ToppCell10x5'-GI_small-bowel-Myeloid_Mac-Intestinal_macrophages|GI_small-bowel / Manually curated celltypes from each tissue

DMXL2 CTTNBP2 TLR7 CST3 SIGLEC11 TNFAIP2 EMP2

1.70e-051961837075e5746fa5cb121115a1d51b823c0fbf8d54305
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 NCKAP1 SPTBN2 DUOX2 AKR1C2 MYH14 ATP6V0A4

1.76e-0519718375c4cee914baf7cb43e9cb99cc9e3ae823856dc15
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_basal-Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

VSNL1 KRT15 ANKS1B SEMA5A ITGA2 SRGAP3 ADGRL2

1.76e-0519718371e915957ea6a4550ecb9d6ee4b232aa5800faf20
ToppCell3'-Broncho-tracheal|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

VSNL1 KRT15 SEMA5A ITGA2 AKR1C1 AKR1C2 SRGAP3

1.76e-0519718375d33f8a6940431093e927b186fb9b630a89d8ec1
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Basal_1-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SH3TC2 VSNL1 KRT15 SPTBN2 ITGA2 SRGAP3 KCNAB3

1.76e-05197183758d809ccb8cc4b1e76acf0b8f996cd0e2637290c
ToppCellControl-Stromal-Fibroblast|Stromal / Disease state, Lineage and Cell class

FNDC3B SH3TC2 ANK2 AKR1C1 AKR1C2 CST3 TNFAIP2

1.76e-05197183764cc5f61c88e9560b0f8f6f3151255dffb5c3d66
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Basal_1|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

SH3TC2 VSNL1 KRT15 SPTBN2 ITGA2 SRGAP3 KCNAB3

1.76e-051971837751f19b00f92e1334f653b870d3f7c0c149ff41a
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_A-Branch_A2_(IPAN/IN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CADM3 ANK2 L1CAM NCAM1 NBEA ELAVL3 LIX1

1.76e-05197183727c044833e471a312a572e0b1c83e4bc8a36e896
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal-midbrain/hindbrain_cells|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

CADM3 ANK2 L1CAM NCAM1 AKR1C1 AKR1C2 ELAVL3

1.76e-051971837c7078f6fcf27319ba8c5ebe700bcae7f1e7e39c1
ToppCellParenchyma_Control_(B.)-Epithelial-TX-Basal_1|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

SH3TC2 VSNL1 KRT15 SPTBN2 ITGA2 SRGAP3 KCNAB3

1.76e-0519718372701864e49878c5f323f5133e2c4b0a5a7fff7f5
ToppCellTracheal-NucSeq-Stromal-Schwann|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CADM3 SH3TC2 RELN ANK2 L1CAM NCAM1 CST3

1.76e-051971837c1b2a3fbd5f4aeb3555d8c372efc86f1052e7c65
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

CADM3 L1CAM NCAM1 AKR1C1 AKR1C2 KIDINS220 ELAVL3

1.76e-0519718372d92b0483d57541aee382dda80e42cf66e813d6b
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CTTNBP2 DOCK10 GRIK4 SLIT2 SRPX2 SRGAP3 ADGRL2

1.76e-0519718370034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCellNS-critical-d_07-13|critical / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NCKAP1 DUOX2 NBEA AKR1C2 SRPX2 CST3 EMP2

1.82e-051981837a6e11c87b31beffb6af190c64b4ef3ee1d9dab8d
ToppCell5'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_A-Branch_A2_(IPAN/IN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CADM3 L1CAM NBEA AKR1C1 AKR1C2 ELAVL3 LIX1

1.82e-0519818377b9c7ce5d6b7df8db85943b65da1a2c202a8bb53
ToppCell3'-Broncho-tracheal-Epithelial|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

VSNL1 KRT15 SEMA5A ITGA2 AKR1C1 AKR1C2 SRGAP3

1.82e-051981837aa6e7218ee6230902854e66c444b544218b30c0e
ToppCellBAL-Severe-Epithelial-Epithelial-Basal/Club|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KRT15 NCKAP1 LMTK3 AKR1C1 AKR1C2 SRPX2 MYH14

1.88e-051991837d04062d86643e5712cc2f519f4f36e643d404a16
ToppCellproximal-Epithelial-Differentiating_Basal-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KRT15 ITGA2 LMTK3 AKR1C1 C9orf152 SRPX2 SRGAP3

1.88e-051991837c607346f60e5997e757e5a31cab412ab3734377b
ToppCellBAL-Severe-Epithelial-Epithelial-Basal/Club-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

KRT15 NCKAP1 LMTK3 AKR1C1 AKR1C2 SRPX2 MYH14

1.88e-051991837a3f83fe5c3c557cd3ef8f5632f7fba5cf1859937
ToppCellBronchus_Control_(B.)-Epithelial-TX-Transitional_AT2|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

CTTNBP2 ANK2 NCAM1 C9orf152 PTP4A3 ASB5 ATP6V0A4

1.88e-051991837cd581d7330b471431ef427f8a4f5be553f70e068
ToppCellNS-moderate-d_16-33-Epithelial|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NCKAP1 AKR1C1 AKR1C2 MYH14 AKR1C3 AK1 EMP2

1.88e-051991837aa2b51940115c22768c0d7493b4b60d41df3f376
ToppCellSevere_COVID-19-Epithelial-Basal/Club|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

KRT15 NCKAP1 LMTK3 AKR1C1 AKR1C2 SRPX2 MYH14

1.88e-0519918372a0aebcfadff4e2dfc8244ad8a87c338ecccacfd
ToppCellBAL-Severe-Epithelial-Epithelial-Basal/Club-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KRT15 NCKAP1 LMTK3 AKR1C1 AKR1C2 SRPX2 MYH14

1.88e-051991837fd364f43859b2e7a3e91ce6a1c430cc42ad26a49
ToppCell5'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CADM3 ANK2 L1CAM NBEA AKR1C1 ELAVL3 LIX1

1.88e-051991837b4824d3683a4e3025b8e74a0f1755b331b2a0ba7
ToppCellBAL-Severe-Epithelial-Epithelial-Basal/Club|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

KRT15 NCKAP1 LMTK3 AKR1C1 AKR1C2 SRPX2 MYH14

1.88e-051991837644197ff7e3299587881dd678836262e670ed4a8
ToppCellPSB-critical-LOC-Epithelial|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NCKAP1 NBEA MYH14 AKR1C3 AK1 EMP2 CYB561

1.88e-05199183758dcb0eedafa8629585dc99e53147e2287f49689
ToppCellproximal-3-Epithelial-Differentiating_Basal|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KRT15 ITGA2 LMTK3 AKR1C1 C9orf152 SRPX2 SRGAP3

1.88e-05199183712e07084fc2d5d4c418df564ccc0e132b056e549
ToppCellproximal-Epithelial-Differentiating_Basal|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KRT15 ITGA2 LMTK3 AKR1C1 C9orf152 SRPX2 SRGAP3

1.88e-05199183796a89a2578fad9a99c52d2cf9e26e06516a96568
ToppCellNeuron-Postmitotic-Excitatory_Neuron_|World / Primary Cells by Cluster

CTTNBP2 ANK2 NCAM1 NBEA YWHAZ KIDINS220 ELAVL3

1.88e-051991837058373b4ac3cec2108cb24265628ff0a50646e33
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-Basal_2|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

VSNL1 KRT15 ITGA2 AKR1C1 AKR1C2 SRGAP3 AKR1C3

1.94e-052001837c7668e26c6b8cfa6d174b0634e43c230425faba9
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal|GW16 / Sample Type, Dataset, Time_group, and Cell type.

CTTNBP2 L1CAM NCAM1 AKR1C1 AKR1C2 YWHAZ KIDINS220

1.94e-05200183784e4565d28a02700bf7f6730d1b3a58744ca0aea
ToppCellParenchyma_COVID-19-Epithelial-TX-Basal_2|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

VSNL1 KRT15 ITGA2 AKR1C1 AKR1C2 SRGAP3 AKR1C3

1.94e-052001837bce9bce9eb622bc6514708d49ca4a6604043c22a
ToppCellSevere-Epithelial-Epithelial-|Severe / Condition, Lineage, Cell class and cell subclass

KRT15 NCKAP1 LMTK3 AKR1C1 AKR1C2 MYH14 EMP2

1.94e-0520018378669ce08f93eefb8ac970e30cdc4b1f908023c54
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Cortical_neuron|5w / Sample Type, Dataset, Time_group, and Cell type.

RELN NCAM1 AKR1C1 AKR1C2 KIDINS220 ELAVL3 AK1

1.94e-052001837085060d148158f7d9e938b6c4a3700ccbb3bca15
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_alveolar-AT1|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

KRT15 SEMA5A ABCA7 RANBP17 MYH14 EMP2 SEMA3E

1.94e-0520018373d51aebf626dd4656ab4aac8a20d761b8062c42d
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal-Cortical_neuron|GW16 / Sample Type, Dataset, Time_group, and Cell type.

CTTNBP2 L1CAM NCAM1 AKR1C1 AKR1C2 YWHAZ KIDINS220

1.94e-05200183719055194a5e0ea122f1b8fc62df44813f6843c95
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW16-Neuronal|GW16 / Sample Type, Dataset, Time_group, and Cell type.

CTTNBP2 L1CAM NCAM1 AKR1C1 AKR1C2 YWHAZ KIDINS220

1.94e-0520018371decf1d2cba5ebfd3e5cd4bcd637db8f193033ce
ToppCellmoderate-Epithelial|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DUOX2 AKR1C1 AKR1C2 MYH14 AKR1C3 AK1 EMP2

1.94e-052001837095783c9b75113ae350c2d5fb1195d71b41fa695
ToppCellNS-moderate-d_0-4-Epithelial|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

AHI1 CFAP298 AKR1C1 MYH14 SRGAP3 AKR1C3 EMP2

1.94e-05200183764462a18afca3c1a8548a857924b8166058bf958
ToppCellSevere-Epithelial|Severe / Condition, Lineage, Cell class and cell subclass

KRT15 NCKAP1 LMTK3 AKR1C1 AKR1C2 MYH14 EMP2

1.94e-0520018376ead9db88568bb829d564a6d8e85f71fd765bac0
ToppCellBrain_organoid-organoid_Tanaka_cellReport-3m-Neuronal|3m / Sample Type, Dataset, Time_group, and Cell type.

CADM3 CTTNBP2 ANK2 NCAM1 NBEA KIDINS220 ELAVL3

1.94e-052001837af99d90070e2933fd2e9512590c6cf3bd6e15539
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-Basal_2-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

VSNL1 KRT15 ITGA2 AKR1C1 AKR1C2 SRGAP3 AKR1C3

1.94e-052001837621dd6438ef6e71811d3644b75209535b7c0f8f7
ToppCellBronchus_Control_(B.)-Epithelial-TX-Basal_2|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

ITGA2 LMTK3 AKR1C1 AKR1C2 AKR1C3 EMP2 GRHL3

1.94e-0520018370fa3340d945f00ef55c7603476d51bd8346e82c2
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Interneuron|5w / Sample Type, Dataset, Time_group, and Cell type.

RELN VSNL1 L1CAM NCAM1 AKR1C1 AKR1C2 KIDINS220

1.94e-052001837c7e33057466915d4e2b34f2062b22d9cdffa69dc
ToppCellSevere-Epithelial-Epithelial|Severe / Condition, Lineage, Cell class and cell subclass

KRT15 NCKAP1 LMTK3 AKR1C1 AKR1C2 MYH14 EMP2

1.94e-0520018373bd1ce2793651c9badd69f011d2531183594e5f4
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Bcl6|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SLC26A4 KCNK12 RYR1 NEFH KCNG1 CCDC87

2.92e-05144183608005be9e3367f78ef27e125d9cce5ca53f4bd2d
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPTBN2 PXK SLIT2 SRGAP3 ATP6V0A4 ABTB2

3.67e-05150183687968ce885a4959616f0321f58517fe8029ba1b1
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell-Schwann_Cell_/_Neural-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GLRA3 NCAM1 GRIK4 HMCN2 ASB5 KCNG1

4.25e-05154183630cb4bb297fa815adb829f3b5cafca56fcbcb810
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GLRA3 NCAM1 GRIK4 HMCN2 ASB5 KCNG1

4.25e-05154183642bd8f88fd075a2d4edde394785decad88a2660a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GLRA3 NCAM1 GRIK4 HMCN2 ASB5 KCNG1

4.25e-0515418366425d9861148586466febd6eceae1b1f9b9a14c1
ToppCellE16.5-samps-Epithelial-Alveolar_epithelial_precursor-Noncycling_AT1_Precursor|E16.5-samps / Age Group, Lineage, Cell class and subclass

KRT15 TLCD4 NOXA1 ITIH2 MYH14 SEMA3E

4.25e-0515418368a643d91896af9b630a715fb284c1523d01ad1a3
Drugcloxazolam

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.04e-0941834ctd:C005522
DrugPregnanes

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.04e-0941834ctd:D011278
Drugtetralol

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.04e-0941834ctd:C019106
Drug3',3'',5',5''-tetrabromophenolphthalein

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.04e-0941834ctd:C018156
Drugoctyl gallate

AKR1C4 AKR1C1 AKR1C2 NEFH AKR1C3

7.75e-09101835ctd:C016627
DrugHydroxysteroids

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.01e-0851834ctd:D006914
Drugcresolphthalein

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.01e-0851834ctd:C010092
DrugMedazepam

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.98e-0861834ctd:D008472
DrugNitrazepam

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.76e-0781834ctd:D009567
DrugChrysenes

AKR1C4 AKR1C1 AKR1C2 AKR1C3 NOS3

4.46e-07201835ctd:D002911
Drug4-hydroxybenzoic acid

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.93e-0791834ctd:C038193
Drug20-alpha-Dihydroprogesterone

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.93e-0791834ctd:D004092
Drugcyclopentanol

AKR1C1 AKR1C2 AKR1C3

5.11e-0731833ctd:C016327
Drugcyclopentanone

AKR1C1 AKR1C2 AKR1C3

5.11e-0731833ctd:C007201
Drug5-dihydrodeoxycorticosterone

AKR1C4 AKR1C1 AKR1C2

5.11e-0731833ctd:C454687
Drug4-benzoylbenzoic acid

AKR1C1 AKR1C2 AKR1C3

5.11e-0731833ctd:C058818
Drugdichloro(4-cymene)ruthenium(II)

AKR1C1 AKR1C2 AKR1C3

5.11e-0731833ctd:C530610
DrugDihydroxydihydrobenzopyrenes

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.28e-06111834ctd:D004101
Drugchlordecone alcohol

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.28e-06111834CID000013946
DrugPhenolphthalein

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.90e-06121834ctd:D020113
Drugtetrahydrodeoxycorticosterone

AKR1C4 AKR1C1 AKR1C2

2.03e-0641833ctd:C009413
Druggliquidone

AKR1C1 AKR1C2 AKR1C3

2.03e-0641833ctd:C010969
DrugDBD-H

AKR1C4 AKR1C1 AKR1C3

2.03e-0641833CID000131382
DrugDMBA-3,4-dihydrodiol

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.73e-06131834CID000050096
Drugflunisolide

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.73e-06131834ctd:C007734
DrugAC1L1KF5

AKR1C4 APOE AKR1C1 AKR1C2 RYR1 RYR2 AKR1C3 NOS3

3.73e-061131838CID000005470
Drug5-alpha-Dihydroprogesterone

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.80e-06141834ctd:D043582
Drug1-acenaphthenol

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.80e-06141834CID000022750
DrugMeclofenamic Acid

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.80e-06141834ctd:D008469
DrugCeftazidime pentahydrate [78439-06-2]; Up 200; 6.2uM; PC3; HT_HG-U133A

VSNL1 NCAM1 SEMA5A KCNK12 APOE ITIH2 RNASEL MYH14 SRGAP3 TNFAIP2

4.63e-06197183105054_UP
DrugNSC86000

AKR1C1 AKR1C2 AKR1C3

5.05e-0651833CID000257630
DrugAmidopyrine [58-15-1]; Up 200; 17.2uM; MCF7; HT_HG-U133A

SPTBN2 KCNK12 ACAD10 H6PD APOE ITIH2 RYR1 RYR2 MEP1B UBA7

5.06e-06199183106818_UP
DrugCQ-S

B4GAT1 AKR1C2 RYR1 ELF2

8.86e-06171834CID000072462
DrugAC1L93E5

AKR1C4 AKR1C1 AKR1C3

1.00e-0561833CID000412383
DrugEstazolam

AKR1C1 AKR1C2 AKR1C3

1.00e-0561833ctd:D004949
Drug3-hydroxyhexobarbital

AKR1C4 AKR1C2 AKR1C3

1.00e-0561833CID000439898
DrugGlipizide

AKR1C1 AKR1C2 AKR1C3

1.00e-0561833ctd:D005913
Drugacenaphthene-1-ol

AKR1C1 AKR1C2 AKR1C3

1.00e-0561833ctd:C023723
Drugoxcarbazepine

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.42e-05191834ctd:C036006
DrugAC1O70V5

CTTNBP2 L1CAM AKR1C4 RNASEL AKR1C3

1.47e-05391835CID006540300
Drug4-hydroxyequilenin-o-quinone

AKR1C1 AKR1C2 AKR1C3

1.75e-0571833ctd:C117714
Drugzomepirac

AKR1C1 AKR1C2 AKR1C3

1.75e-0571833ctd:C020549
Drugbenzo(a)pyrene-7,8-dione

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.77e-05201834ctd:C076588
DrugFlunitrazepam

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.17e-05211834ctd:D005445
Drugbenzene dihydrodiol

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.64e-05221834CID000000418
Drug2-cyclohexen-1-ol

AKR1C4 AKR1C2 AKR1C3

2.78e-0581833CID000013198
Drugnaphthalene-1,2-dihydrodiol

AKR1C4 AKR1C1 AKR1C2 AKR1C3 NOS3

2.99e-05451835CID000000362
DrugAlfuzosin hydrochloride [81403-68-1]; Up 200; 9.4uM; MCF7; HT_HG-U133A

CADM3 DMXL2 APOE PDE10A RYR2 KIDINS220 CCDC87 ELAVL3 TNK2

3.22e-0519718395242_UP
Drugalpha-estradiol; Up 200; 0.01uM; MCF7; HG-U133A

CADM3 DNAH3 DOCK10 SIAH1 NFS1 LARS2 ZC3H7A SRGAP3 MINDY1

3.35e-051981839762_UP
DrugClemizole hydrochloride [1163-36-6]; Up 200; 11uM; MCF7; HT_HG-U133A

ANK2 NCAM1 PDE10A RYR1 PTP4A3 KIDINS220 NF1 ELAVL3 AK1

3.35e-0519818394695_UP
DrugOxethazaine [126-27-2]; Up 200; 8.6uM; PC3; HT_HG-U133A

KCNK12 AKR1C4 PLXND1 PDE10A TBC1D8B ITIH2 NF1 CLCN7 MYH14

3.35e-0519818394246_UP
DrugLoracarbef [121961-22-6]; Up 200; 10.8uM; MCF7; HT_HG-U133A

ABCA2 SEMA5A H6PD APOE RYR1 MEP1B UBA7 NF1 TNK2

3.35e-0519818393532_UP
DrugPiperidolate hydrochloride [129-77-1]; Down 200; 11.2uM; MCF7; HT_HG-U133A

SHMT1 ACAD10 AXIN1 ATP6V0A4 AK1 DHX35 TNFAIP2 WDFY3 CYB561

3.35e-0519818393551_DN
DrugEthionamide [536-33-4]; Down 200; 24uM; PC3; HT_HG-U133A

AHI1 SPTBN2 PLXND1 ABCA7 PTP4A3 TTC23 ASB7 DHX35 WDFY3

3.49e-0519918394593_DN
DrugEdrophonium chloride [116-38-1]; Down 200; 19.8uM; PC3; HT_HG-U133A

SPTBN2 SEMA5A PLXND1 ABCA7 ZNF675 KIDINS220 NF1 CLCN7 MYH14

3.49e-0519918396655_DN
DrugLeflunomide [75706-12-6]; Down 200; 14.8uM; HL60; HT_HG-U133A

HYAL4 DMXL2 AHI1 ACAD10 YWHAZ NF1 KCNG1 WDFY3 KCNAB3

3.49e-0519918392539_DN
Drugfluphenazine dihydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A

ABCA2 SIAH1 PLXND1 LARS2 YWHAZ AXIN1 NF1 ASB7 TNK2

3.63e-0520018396996_DN
DrugBupropion hydrochloride [31677-93-7]; Down 200; 14.4uM; PC3; HT_HG-U133A

DOCK1 SH3TC2 SEMA5A RYR2 IFNAR1 FARP2 PTP4A3 MYH14 WDFY3

3.63e-0520018395782_DN
DrugGlycyrrhetinic Acid

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.78e-05241834ctd:D006034
DrugHb H

H6PD KIDINS220 AK1 LRBA SNRPD3

4.11e-05481835CID000466959
Drug9,10-phenanthrenequinone

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.48e-05251834ctd:C005399
DrugPregnanolone

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.48e-05251834ctd:D011280
Drughydride

B4GAT1 SLC26A4 COX6C SHMT1 DUOX2 ARHGAP9 AKR1C4 ITGA2 H6PD AKR1C1 AKR1C2 RYR1 UBA7 ATP6V0A4 AKR1C3 SLC25A11 FAR1 EMP2 NOS3

4.59e-0583518319CID000000783
Drugandrostane-3,17-dione

AKR1C4 H6PD AKR1C1 AKR1C2 AKR1C3

5.53e-05511835CID000000443
Drugalpha-methylcinnamic acid

AKR1C1 AKR1C3

6.43e-0521832ctd:C510582
Drug(10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE

AKR1C1 AKR1C2

6.43e-0521832DB07768
Drugbaccharin

AKR1C2 AKR1C3

6.43e-0521832ctd:C012764
DrugHexestrol

SIAH2 AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.98e-05551835ctd:D006589
Drugcoenzyme 1

SHMT1 DUOX2 SIAH1 AKR1C4 H6PD AKR1C1 AKR1C2 RYR1 RYR2 RCOR1 AKR1C3 SLC25A11 FAR1 EMP2 NOS3

1.00e-0459618315CID000000925
Drugphenolphthalein

AKR1C4 AKR1C1 AKR1C2 ITIH2 AKR1C3

1.03e-04581835CID000004764
Drugfenamic acid

AKR1C1 AKR1C2 AKR1C3

1.07e-04121833ctd:C001209
Drugbenzo(a)pyrene 7,8-dihydrodiol

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.07e-04311834ctd:C017228
Drugpicrotoxin

B4GAT1 SLC26A4 GLRA3 GRIK4 FARP2 CLCN7 EMP2 NOS3

1.12e-041811838CID000031304
Drug5-ethyluracil

ITGA2 AKR1C2 LRBA

1.38e-04131833CID000073267
Drug4-formyl-benzoate

AKR1C4 AKR1C1 AKR1C2

1.38e-04131833CID000012088
DrugApralan

CTTNBP2 RTL10 H6PD PTP4A1

1.55e-04341834CID000071428
Drugtroglitazone; Down 200; 10uM; HL60; HT_HG-U133A

DNAH3 AHI1 ACAD10 PLXND1 NCDN ZNF675 TNFAIP2 CYB561

1.68e-0419218381173_DN
DrugPrednisolone [50-24-8]; Up 200; 11uM; PC3; HT_HG-U133A

DOCK10 GRIK4 TBC1D8B UBA7 NF1 MYH14 SRGAP3 SYK

1.68e-0419218385101_UP
DrugRapamycin; Up 200; 0.1uM; PC3; HT_HG-U133A

ITGA2 APOE ABCA7 FARP2 NF1 CLCN7 HRG SEMA3E

1.74e-0419318384466_UP
DrugDydrogesterone

AKR1C1 AKR1C2 AKR1C3

1.74e-04141833ctd:D004394
Drug6-.beta.-Naltrexol

AKR1C4 AKR1C1 AKR1C2

1.74e-04141833CID000631219
Drug3-hydroxyandrostan-17-one

ACP2 AKR1C4 H6PD AKR1C1 AKR1C2 AKR1C3

1.77e-041021836CID000000225
DrugButoconazole nitrate [32872-77-1]; Down 200; 8.4uM; HL60; HT_HG-U133A

DNAH3 NCDN KIDINS220 NF1 DHX35 TNFAIP2 MINDY1 CYB561

1.80e-0419418382427_DN
DrugPHA-00745360 [351320-33-7]; Down 200; 10uM; PC3; HT_HG-U133A

AHI1 KRT15 PLXND1 TBC1D8B MAP3K6 YWHAZ RYR2 FARP2

1.80e-0419418384559_DN
DrugCefixime [79350-37-1]; Down 200; 8.8uM; HL60; HT_HG-U133A

DNAH3 INTS7 ITGA2 PLXND1 YWHAZ PTP4A3 NF1 TNFAIP2

1.80e-0419418381310_DN
Drug5211181; Up 200; 12uM; MCF7; HT_HG-U133A_EA

YTHDC2 H6PD AXIN1 RNASEL TTC23 KCNG1 AKR1C3 CYB561

1.87e-041951838834_UP
DrugCefamandole sodium salt [30034-03-8]; Up 200; 8.2uM; PC3; HT_HG-U133A

SHMT1 POU1F1 ACAD10 TBC1D8B NF1 AK1 WDFY3 ADGRL2

1.87e-0419518387394_UP
DrugThiamphenicol [15318-45-3]; Up 200; 11.2uM; MCF7; HT_HG-U133A

AHI1 BBS1 KCNK12 AXIN1 SLIT2 PTP4A3 TTC23 KCNG1

1.87e-0419518387033_UP
DrugBiperiden hydrochloride [1235-82-1]; Down 200; 11.4uM; HL60; HT_HG-U133A

CADM3 UBA7 KIDINS220 NF1 KCNG1 TNK2 TNFAIP2 CYB561

1.87e-0419518382460_DN
DrugFluspirilen [1841-19-6]; Down 200; 8.4uM; PC3; HT_HG-U133A

DOCK1 NCKAP1 SPTBN2 H6PD RYR2 ZNF675 NF1 TNFAIP2

1.87e-0419518386662_DN
DrugTrifluridine [70-00-8]; Up 200; 13.6uM; PC3; HT_HG-U133A

AHI1 SHMT1 KCNK12 PLXND1 ZNF675 NF1 MYH14 AK1

1.87e-0419518385819_UP
Drugcis-diammineplatinum(II

RYR1 RYR2

1.92e-0431832CID000159790
Drug2-hydroxyheptanoic acid

RYR1 RYR2

1.92e-0431832CID002750949
Drug8N3-cADPR

RYR1 RYR2

1.92e-0431832CID000127713
Drugaminodantrolene

RYR1 RYR2

1.92e-0431832CID009570289
Drug2-hydroxycarbazole

RYR1 RYR2

1.92e-0431832CID000093551
DrugSomnium

NF1 GRHL3

1.92e-0431832CID003082954
DrugRyanodyl 3-(pyridine-3-carboxylate

RYR1 RYR2

1.92e-0431832CID005748312
Drugrosiglitazone; Up 200; 10uM; MCF7; HT_HG-U133A

AHI1 KRT15 YTHDC2 KCNK12 KIDINS220 KCNG1 AK1 MINDY1

1.94e-0419618386950_UP
DrugGibberellic acid [77-06-5]; Up 200; 11.6uM; MCF7; HT_HG-U133A

AHI1 RTL10 APOE PTP4A3 UBA7 NF1 KCNG1 AK1

1.94e-0419618387330_UP
DiseaseNeoplasms, Hormone-Dependent

AKR1C1 AKR1C2 AKR1C3

2.23e-0731803C0027661
Diseasetransient cerebral ischemia (biomarker_via_orthology)

ANK2 BCL2L2 APOE NEFH SLIT2 NF1 NOS3 KDM1A SEMA3E

5.58e-071571809DOID:224 (biomarker_via_orthology)
DiseaseIntersex Conditions

AKR1C1 AKR1C2 AKR1C3

2.21e-0651803C2930618
DiseaseSex Differentiation Disorders

AKR1C1 AKR1C2 AKR1C3

2.21e-0651803C2930619
DiseaseHermaphroditism

AKR1C1 AKR1C2 AKR1C3

2.21e-0651803C0019269
DiseaseAmbiguous Genitalia

AKR1C1 AKR1C2 AKR1C3

2.21e-0651803C0266362
DiseasePseudohermaphroditism

AKR1C1 AKR1C2 AKR1C3

2.21e-0651803C0033804
DiseaseDisorders of Sex Development

AKR1C1 AKR1C2 AKR1C3

7.67e-0671803C0036875
Diseasehypothyroidism (biomarker_via_orthology)

RELN L1CAM NCAM1 APOE NEFH NOS3

9.80e-06801806DOID:1459 (biomarker_via_orthology)
DiseaseAlzheimer disease

APOE ABCA7 NOS3

1.22e-0581803cv:C0002395
DiseaseAcute Confusional Senile Dementia

RELN VSNL1 APOE ABCA7 CST3 NOS3

3.32e-05991806C0546126
DiseaseAlzheimer Disease, Late Onset

RELN VSNL1 APOE ABCA7 CST3 NOS3

3.32e-05991806C0494463
DiseaseAlzheimer's Disease, Focal Onset

RELN VSNL1 APOE ABCA7 CST3 NOS3

3.32e-05991806C0750900
DiseaseAlzheimer Disease, Early Onset

RELN VSNL1 APOE ABCA7 CST3 NOS3

3.32e-05991806C0750901
DiseasePresenile dementia

RELN VSNL1 APOE ABCA7 CST3 NOS3

3.32e-05991806C0011265
DiseaseFamilial Alzheimer Disease (FAD)

RELN VSNL1 APOE ABCA7 CST3 NOS3

3.51e-051001806C0276496
DiseaseMALE PSEUDOHERMAPHRODITISM: DEFICIENCY OF TESTICULAR 17,20-DESMOLASE

AKR1C4 AKR1C2

3.70e-0521802C1839840
Disease46,XY disorder of sex development due to testicular 17,20-desmolase deficiency

AKR1C4 AKR1C2

3.70e-0521802cv:C1839840
Disease46,XY SEX REVERSAL 8

AKR1C4 AKR1C2

3.70e-0521802614279
Disease46,XY sex reversal 8 (is_implicated_in)

AKR1C4 AKR1C2

3.70e-0521802DOID:0111773 (is_implicated_in)
Diseaseneurofibroma

NF1 SUZ12

3.70e-0521802C0027830
DiseaseAlzheimer's Disease

RELN VSNL1 APOE ABCA7 CST3 NOS3

3.72e-051011806C0002395
Diseaseobesity (is_marker_for)

AHI1 APOE AKR1C1 AKR1C2 CST3 AK1

3.72e-051011806DOID:9970 (is_marker_for)
DiseaseEndometrial Carcinoma

CHD4 AKR1C1 AXIN1 AKR1C3 SUZ12

8.03e-05721805C0476089
DiseaseCoronary Artery Vasospasm

ARHGAP9 NOS3

1.11e-0431802C0010073
Diseasecongenital myopathy 1A (implicated_via_orthology)

RYR1 RYR2

1.11e-0431802DOID:3529 (implicated_via_orthology)
Diseasemalignant hyperthermia (implicated_via_orthology)

RYR1 RYR2

1.11e-0431802DOID:8545 (implicated_via_orthology)
DiseaseGlobal developmental delay

SPTBN2 NBEA FHIP2A SUZ12 CNOT1 KDM1A

1.71e-041331806C0557874
Diseasecocaine use disorder

C2CD6 ADGRL2

2.20e-0441802EFO_0010445
DiseaseMelanocytic nevus

NF1 SUZ12

2.20e-0441802C0027962
DiseaseSchwannomatosis, Plexiform

NF1 SUZ12

3.66e-0451802C0751374
DiseasePerineurioma

NF1 SUZ12

3.66e-0451802C0751691
DiseaseNerve Sheath Tumors

NF1 SUZ12

3.66e-0451802C0206727
DiseasePeripheral Nerve Sheath Neoplasm

NF1 SUZ12

3.66e-0451802C0751689
DiseaseArteriosclerosis

APOE NOS3

3.66e-0451802C0003850
DiseaseEndometrioid carcinoma ovary

MAP3K6 TNK2

3.66e-0451802C0346163
DiseaseEndometrial Neoplasms

CHD4 AKR1C1 AKR1C3 SUZ12

4.39e-04581804C0014170
Diseasecortolone glucuronide (1) measurement

AKR1C2 AKR1C3

5.46e-0461802EFO_0800552
Diseaseprostate cancer

MTNR1A HOXB13

5.46e-0461802MONDO_0008315
DiseaseNeurilemmoma

NF1 SUZ12

5.46e-0461802C0027809
DiseaseMental deterioration

APOE IFNAR1 DNAH11

7.26e-04291803HP_0001268
DiseaseBipolar Disorder

RELN NCAM1 GRIK4 AKR1C4 APOE PDE10A LARS2 YWHAZ TAAR6 NOS3

7.37e-0447718010C0005586
Diseaselevel of Sterol ester (27:1/22:6) in blood serum

FNDC3B APOE

7.62e-0471802OBA_2045201
Diseaseangle-closure glaucoma (is_implicated_in)

APOE NOS3

7.62e-0471802DOID:13550 (is_implicated_in)
DiseaseGoiter

SLC26A4 DUOX2

7.62e-0471802C0018021
DiseaseEarly-onset autosomal dominant Alzheimer disease

APOE NOS3

7.62e-0471802cv:CN043596
Diseasecocaine use disorder, social environment measurement

STRADB ADGRL2

1.01e-0381802EFO_0010445, EFO_0010552
Diseaselateral ventricle volume measurement

SEMA5A GRIK4 ABTB2

1.06e-03331803EFO_0008487
Diseasesensorineural hearing loss (is_implicated_in)

ITGA2 APOE MYH14

1.06e-03331803DOID:10003 (is_implicated_in)
Diseaseretinal degeneration (implicated_via_orthology)

RAB6D RAB6C NOS3

1.06e-03331803DOID:8466 (implicated_via_orthology)
DiseaseAutistic Disorder

RELN AHI1 SEMA5A NBEA CHD4 FARP2 NF1

1.15e-032611807C0004352
DiseaseAntihypertensive use measurement

ARHGAP15 INO80 PDE10A PTP4A3 LRBA NOS3 CYB561

1.26e-032651807EFO_0009927
DiseaseProstatic Cancer, Castration-Resistant

AKR1C3 KDM1A

1.30e-0391802C3658266
DiseaseProstatic Neoplasms, Castration-Resistant

AKR1C3 KDM1A

1.30e-0391802C3658267
DiseaseAlcoholic Intoxication, Chronic

NCAM1 SEMA5A AKR1C4 APOE PDE10A PTP4A1 AKR1C3

1.34e-032681807C0001973
DiseaseCardiovascular Diseases

APOE CST3 NOS3

1.37e-03361803C0007222
DiseaseBehcet's disease (is_implicated_in)

ITGA2 NOS3 IL23R

1.37e-03361803DOID:13241 (is_implicated_in)
DiseaseDepression, Bipolar

RELN NCAM1 GRIK4 AKR1C4

1.41e-03791804C0005587
Diseasemyocardial infarction

ANKRD31 FNDC3B CTTNBP2 ARHGAP15 ACAD10 APOE CCM2 NOS3

1.45e-033501808EFO_0000612
Diseasecolorectal health

DOCK1 FNDC3B SEMA5A RYR2 SLIT2 DHX35

1.51e-032011806EFO_0008460
DiseaseVENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder)

ANK2 RYR2

1.61e-03101802C1631597
DiseaseAutism Spectrum Disorders

RELN CTTNBP2 RYR2 MTNR1A

1.85e-03851804C1510586
DiseaseTachycardia, Ventricular

RYR2 NOS3

1.96e-03111802C0042514
DiseaseBack pain

DIS3L2 NCAM1 APOE KCNG1

2.01e-03871804HP_0003418
Diseaseplatelet crit

ANKRD31 DNAH3 AHI1 DOCK10 RICTOR APOE PDE10A PXK RCOR1 NF1 DQX1 SYK ELF1 SLC25A11

2.20e-0395218014EFO_0007985
Diseaselymphangioleiomyomatosis (is_marker_for)

RICTOR NOS3

2.35e-03121802DOID:3319 (is_marker_for)
DiseaseNeurodevelopmental Disorders

ANK2 NCKAP1 SRGAP3 WDFY3

2.56e-03931804C1535926
Diseasediabetic retinopathy (biomarker_via_orthology)

SLIT2 NOS3 KDM1A

2.62e-03451803DOID:8947 (biomarker_via_orthology)
Diseaseintracranial aneurysm (biomarker_via_orthology)

CST3 NOS3

2.76e-03131802DOID:10941 (biomarker_via_orthology)
DiseaseCongenital Hypothyroidism

POU1F1 DUOX2

2.76e-03131802C0010308
Diseasegallbladder cancer (is_implicated_in)

RICTOR APOE

2.76e-03131802DOID:3121 (is_implicated_in)
Diseasered blood cell density measurement

DNAH10 SIAH1 RICTOR CHD4 ACAD10 INO80 DPP8 PDE10A ABCC6 PXK FARP2 AK1 EMP2

3.02e-0388018013EFO_0007978
Diseasecongenital hypothyroidism (implicated_via_orthology)

DUOX2 NEFH

3.21e-03141802DOID:0050328 (implicated_via_orthology)
Diseaseorotic acid measurement

ABTB2 DNAH11

3.21e-03141802EFO_0010516
DiseaseKartagener syndrome (implicated_via_orthology)

SLIT2 DNAH11

3.21e-03141802DOID:0050144 (implicated_via_orthology)
Diseaseeating disorder, bipolar disorder

CADM3 RYR2

3.21e-03141802EFO_0005203, MONDO_0004985
Diseasemultiple sclerosis (is_marker_for)

BCL2L2 NEFH CST3

3.35e-03491803DOID:2377 (is_marker_for)
Diseasediabetic retinopathy (is_implicated_in)

ITGA2 APOE NOS3

3.54e-03501803DOID:8947 (is_implicated_in)
Diseasethrombosis (is_implicated_in)

ITGA2 HRG

3.69e-03151802DOID:0060903 (is_implicated_in)
Diseaseresponse to tenofovir

RELN KIDINS220 ADGRL2

3.75e-03511803EFO_0009279
Diseaseattention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement

CTTNBP2 ARHGAP15 NOL6 DOCK10 NCAM1 NBEA RYR2 RANBP17 SLIT2 UBA7 ADGRL2 KCNAB3

3.88e-0380118012EFO_0003888, EFO_0007052, MONDO_0002491
DiseaseCOVID-19, mortality

BPIFC NCAM1 APOE RCOR1 ELF2

3.97e-031701805EFO_0004352, MONDO_0100096
DiseaseMalignant lymphoma, lymphocytic, intermediate differentiation, diffuse

SYK AK1

4.20e-03161802C0334634
Diseaseatherosclerosis (is_implicated_in)

APOE NOS3

4.20e-03161802DOID:1936 (is_implicated_in)
Diseaseresponse to methotrexate

AKR1C1 AKR1C2

4.20e-03161802GO_0031427
Diseasemelanoma

FHIP2A NF1 SYK SUZ12 HOXB13 KDM1A

4.28e-032481806C0025202
DiseaseAgents acting on the renin-angiotensin system use measurement

ARHGAP15 INO80 APOE PDE10A PTP4A3 NOS3 CYB561

4.64e-033351807EFO_0009931
Diseasephenylalanine measurement

APOE LARS2 ABCC6

4.64e-03551803EFO_0005001
DiseaseKuhnt-Junius degeneration (is_implicated_in)

APOE NOS3

4.74e-03171802DOID:10873 (is_implicated_in)
DiseaseLipidemias

APOE NOS3

4.74e-03171802C1706412
Diseasepre-eclampsia (biomarker_via_orthology)

AKR1C3 NOS3

4.74e-03171802DOID:10591 (biomarker_via_orthology)
DiseaseMoyamoya Disease

ABCC6 NF1

4.74e-03171802C0026654
DiseaseHyperlipidemia

APOE NOS3

4.74e-03171802C0020473
Diseasecoronary artery disease, factor VII measurement

SEMA5A APOE NFS1 NOS3

4.83e-031111804EFO_0001645, EFO_0004619
DiseaseAlzheimer's disease (is_marker_for)

RELN L1CAM BCL2L2 APOE CST3 NOS3

5.08e-032571806DOID:10652 (is_marker_for)
DiseaseAlzheimer's disease (implicated_via_orthology)

ANK2 RCOR2 RCOR1

5.13e-03571803DOID:10652 (implicated_via_orthology)
Diseasefactor VIII measurement, coronary artery disease

SEMA5A ACAD10 APOE NOS3

5.15e-031131804EFO_0001645, EFO_0004630
DiseaseBeta blocking agent use measurement

APOE PDE10A NOS3 CYB561

5.31e-031141804EFO_0009929
DiseaseAge-related macular degeneration

APOE CST3

5.31e-03181802cv:C0242383
DiseaseTourette syndrome, schizophrenia

PITPNM2 DNAH10

5.31e-03181802EFO_0004895, MONDO_0005090

Protein segments in the cluster

PeptideGeneStartEntry
ALRYQLQRGVVVLAK

AKR1C4

256

P17516
YKSGEQILRLANERF

ACTR6

261

Q9GZN1
ALNRYIGVRILEQDK

ERICH6

541

Q7L0X2
YYQRGILAKVEGQRL

ELF1

271

P32519
DDLQKRLAVYQAGAR

APOE

171

P02649
IDIQNGFLLRYAVIK

ASB7

176

Q9H672
LLRNLAREGANYALV

B4GAT1

211

O43505
ILVARKFVGAANYRE

AHI1

831

Q8N157
ALRYQLQRGVVVLAK

AKR1C3

256

P42330
VVRQYLARFLEGLAL

RTL10

211

Q7L3V2
RVDLANLYIRTGAKN

DNAH11

2891

Q96DT5
FRVAAILQGVYKRSL

ACAD10

556

Q6JQN1
RALVADFVGYKLRQK

BCL2L2

11

Q92843
QLSGLEKRFEIQRYL

BSX

121

Q3C1V8
QNSRNGLAKLVFIIY

ADGRL2

706

O95490
NGYRLGERVLQVSFK

ELAVL3

346

Q14576
KDFKIRLQYFARGLQ

API5

371

Q9BZZ5
RATFQAYQILIGKDI

ANXA13

206

P27216
INLRQLYGDSRKFLL

CCM2

336

Q9BSQ5
DGKNLRLYQAVVDAR

DMXL2

786

Q8TDJ6
AQQTLYFGEKRALRD

CADM3

66

Q8N126
YFGEKRALRDNRIQL

CADM3

71

Q8N126
VYRGLLADFQALLRA

CCDC87

171

Q9NVE4
FLLLVKGQQADLARY

CDHR5

321

Q9HBB8
IQRRFKDTIINAKYG

DET1

421

Q7L5Y6
GNALLVYRVFRNEAK

CYB561

66

P49447
AFDVLVLRYGVQKRI

DIS3L2

781

Q8IYB7
EGIQFLVTRYIKALN

CC2D2B

1111

Q6DHV5
DVLVLRNLTKVYRGQ

ABCA7

1791

Q8IZY2
VQRAAQYLKVEQLFG

TNK2

986

Q07912
FLRAQYEGLKRQQRT

C9orf152

41

Q5JTZ5
QLLAVQAIRKYGRDF

RCOR1

391

Q9UKL0
EQLLAVQAIRRYGKD

RCOR2

336

Q8IZ40
RFLARLKTNYQLGEL

RANBP17

331

Q9H2T7
AAIDYTQLGLRFKLQ

NOXA1

106

Q86UR1
RAKAGYNVKQLFRRV

RAB6C

156

Q9H0N0
RAKAGYNVKQLFRRV

RAB6D

156

Q53S08
LRIFKNGNVLYSIRL

GLRA3

151

O75311
LKLADVFRVGNNFLR

INTS7

66

Q9NVH2
QRYLRNKDFLLGVNF

INO80

941

Q9ULG1
LRAARAGNLDKVVEY

ANK2

36

Q01484
AFEVAYQLALQARKG

ANKS1B

1181

Q7Z6G8
SINRRNIFGENLVYK

ANKRD31

481

Q8N7Z5
RALLQKYADIDIRGQ

KIDINS220

286

Q9ULH0
NKLRNIRYGFNTILV

FAR1

461

Q8WVX9
DLINKRRRDGYLFQL

HRG

36

P04196
NNIAIKGVARFYRSR

NFS1

131

Q9Y697
AYQGVLVELARANRL

NCDN

686

Q9UBB6
GKFQLVAENRRYQRS

ITIH2

41

P19823
IAFYEKRGIVRKVNA

AK1

161

P00568
KFLIRARDNNGSYAL

SYK

191

P43405
QKLDFRLQQGAYRLL

HMCN2

3796

Q8NDA2
EKAAREYRVNAQGLL

EXD1

316

Q8NHP7
EFCQLGDLKRYLRAQ

LMTK3

211

Q96Q04
YDNREKRAFLLGSVQ

C2CD6

191

Q53TS8
RGFLAQKLQQYKRFV

DUOX2

1021

Q9NRD8
TYALQVARRNLQGIK

FSIP2

2001

Q5CZC0
NQVVGLVTRKDLARY

CLCN7

776

P51798
AGKEREYQALVQRAL

MAP3K6

1181

O95382
NVFQKGIYLLRVQAS

IFNAR1

296

P17181
QAAARGYLARRAFQK

MYH14

811

Q7Z406
RVNGRNIVKANFTIY

PLXND1

686

Q9Y4D7
RNQGLYRLGNFLFIL

KCNK12

271

Q9HB15
IATDLALYFGNRKQL

PDE10A

621

Q9Y233
REILQDKDGLNQRYF

NOL6

186

Q9H6R4
RAVGKLSYNQLVERI

MINDY1

251

Q8N5J2
DQRNGLRVIYKLLAS

LRBA

716

P50851
KYRIQRGALILSNVQ

L1CAM

381

P32004
FRLKYENELALRQGV

KRT15

191

P19012
QRQAIKGAFYRRAQR

KCNG1

31

Q9UIX4
RLGRATQNYKNLLLF

LCN10

131

Q6JVE6
QGLKDVLLTAFAYRQ

FANCG

201

O15287
VIQRANLAYGDFIKS

PITPNM2

531

Q9BZ72
RFGIAVLGYLNRNAL

ITGA2

306

P17301
DAFGYATLKRLQQQR

RICTOR

1326

Q6R327
QNRRDLQKALVSGYF

DQX1

586

Q8TE96
RLQFGVAVIDNKLYV

KLHL4

466

Q9C0H6
QLEEARKAGQELRFY

LIX1

231

Q8N485
DQRRGYKNVFNALIR

SLC25A11

156

Q02978
AAEDLFVNIRGYNKR

NCKAP1

306

Q9Y2A7
FVNIRGYNKRINDIR

NCKAP1

311

Q9Y2A7
RNIRLVQFYIQIGSK

RELN

1501

P78509
YRVSGNLAVIQKLRF

ARHGAP12

691

Q8IWW6
AQSYAQQLGRLFRKA

NOS3

531

P29474
KRQRYRLSAQAEGLQ

NOS3

731

P29474
RFLFGIYQQAEKARL

ACP2

241

P11117
RAAIEREYGQALQKL

FCHSD1

46

Q86WN1
LQALNDRFAGYIDKV

NEFH

101

P12036
IFVLQLFRLKQGERF

EMP2

81

P54851
VARVYNGRLKVQRLC

CFAP298

31

P57076
RDNYDQLVRIAKFLG

CSNK2A3

236

Q8NEV1
QAKEGDLQRVLLYVR

GRHL3

506

Q8TE85
GLDIKLNTAVRQVRY

KDM1A

581

O60341
KARITQRALDYGVQA

BPIFC

31

Q8NFQ6
GVVQNNRLRKYAFEL

DOCK10

246

Q96BY6
ILDVCLQNFRYLGKR

DOCK10

1371

Q96BY6
RSRILFNQLYENKGE

DOCK1

751

Q14185
RNRYLTGLQKLDFAA

DNAH3

2676

Q8TD57
RKEVFIQERYGRFNL

CTTNBP2

66

Q8WZ74
QLEDRNKRFISIYRG

FNDC3B

996

Q53EP0
NYKGLVRAATVREQL

DHX35

571

Q9H5Z1
ARAIYRKYILDNNGI

AXIN1

141

O15169
LVNNRFKGVKYFRLN

DPP8

676

Q6V1X1
LGVAALYKFRVADQR

COX6C

31

P09669
KARGQNVTIFYVNRL

HYAL4

81

Q2M3T9
FYKNGIKERFQITRI

IL23R

66

Q5VWK5
IAVRRAAQVFYNNKG

ABCA2

1721

Q9BZC7
FYIVKGNRKEAARIA

ASB5

41

Q8WWX0
YYQRGILAKVEGQRL

ELF2

271

Q15723
KGQQRRYFIAAEKIL

HEPHL1

376

Q6MZM0
QVLVFYTKLLGRIRQ

FHIP2A

106

Q5W0V3
GRRYAINLDVQKEAI

FAM111B

371

Q6SJ93
AEILRFNYKIRLVGD

GRIK4

456

Q16099
AAVENQLSGYLLRKF

FARP2

926

O94887
ALDERVGYARILFKN

H6PD

361

O95479
GQLRELEREYAANKF

HOXB13

226

Q92826
ANGEVRIYRDKALLN

BBS1

351

Q8NFJ9
IEVLGFNARQRKAFL

CHD4

1411

Q14839
LQEDKFLRYTAGIQR

DNAH10

696

Q8IVF4
IEKRFAFGFLQQLLR

RYR1

2951

P21817
DILKFLQINGYAVSR

RYR2

2891

Q92736
NAKGVILNAFERYRL

MEP1B

86

Q16820
VRARKQIVAGVNYFL

CST3

76

P01034
YLRRSGIGNVFIKNL

PABPC4L

91

P0CB38
RLAGDKYQAAVQALR

SHMT1

451

P34896
ERLQLGYVDIVFANR

KCNAB3

186

O43448
IRQLNLYGFRKVVLG

HSF5

81

Q4G112
LYGNIFLVARRQAKK

TAAR6

216

Q96RI8
QRLGFYASLLKRQLN

LARS2

6

Q15031
LLAQKGLFYRLAQES

ABCC6

1486

O95255
ANEFKVRRIKLGYTQ

POU1F1

136

P28069
FRQQLYGIKTRDAIL

SLC25A51

56

Q9H1U9
FDQRNGIRVIYKLLA

NBEA

741

Q8NFP9
FYVGKDRKQNRLVIV

GIN1

51

Q9NXP7
NLLLSVKYGRFQGQR

EPPK1

816

P58107
YRVSGNLATIQKLRF

ARHGAP15

316

Q53QZ3
LKFLYKRGANVNLRR

RNASEL

141

Q05823
LIGTRKQAENFAYRL

SIAH1

211

Q8IUQ4
LIGTRKQAENFAYRL

SIAH2

251

O43255
AKSYLRALNRAQEVG

SH3TC2

856

Q8TF17
FRQQLYGIKTRDAVL

SLC25A52

56

Q3SY17
AYRKGIILFISRNRQ

MRPS2

136

Q9Y399
IDAFQRAAGVLNYLK

RHPN2

246

Q8IUC4
LDRQLIRLCQKFGEY

SEC23A

546

Q15436
GQKELVVGARNYLFR

SEMA5A

66

Q13591
VVGARNYLFRLQLED

SEMA5A

71

Q13591
ALLEQDAFRQLIYGR

ABTB2

981

Q8N961
RNLLSVAYKNVVGAR

YWHAZ

41

P63104
ALRYQLQRGVVVLAK

AKR1C1

256

Q04828
ALRYQLQRGVVVLAK

AKR1C2

256

P52895
QAALAVLLYRAAGQR

CNNM3

206

Q8NE01
EGRYLFLNAIANQLR

CNOT1

2261

A5YKK6
FIVLSNNYLQIRGIK

NCAM1

166

P13591
LQKGEFILATRGLRY

ZDHHC6

351

Q9H6R6
GQNVKLRYFLRATIS

VPS26B

121

Q4G0F5
NYRNLVFLGIAVSKL

ZNF99

36

A8MXY4
YQRAFNEFLERGKQL

TNFAIP2

401

Q03169
NEFLERGKQLTNYRA

TNFAIP2

406

Q03169
YEDAIQFIRQKRRGA

PTP4A3

126

O75365
LIRNARYAEAVQLLG

TTC30B

21

Q8N4P2
GRLNLEEFQQLYVKF

VSNL1

41

P62760
LAFQKGIRNKVYQRF

WDFY3

2641

Q8IZQ1
GKRLEDALRAQQFYR

SPTBN2

1581

O15020
RDINSVAGVLKLYFR

SRGAP3

571

O43295
GFDAIRVYNKRLKAL

SLC26A4

571

O43511
YFNRRIIGALVDQAV

TBC1D8B

606

Q0IIM8
FQEKLRRQHYLLVGA

UBA7

426

P41226
AAGLLDQFYEKQRLL

SRPX2

331

O60687
VFDKNRRLQLLDGEY

SUZ12

301

Q15022
RRFKTGQINGDLLIY

NF1

1611

P21359
REFIAERQKGLQNYL

PXK

86

Q7Z7A4
LVLKNGVLAYIGNFR

TLCD4

131

Q96MV1
IYRVSGNLAVVQKLR

ARHGAP9

576

Q9BRR9
AFRGAVDIKNLQLDY

SLIT2

146

O94813
IDAFQRAAGVLNYLK

RHPN2P1

161

A8MT19
AQLEQVYIRGSKIRF

SNRPD3

56

P62318
REGDNRYLQLFKNLL

TLR7

636

Q9NYK1
NYRNLVFLGIAVSKQ

ZNF675

36

Q8TD23
IFIIFYQGEQLRQKI

ATP6V0A4

221

Q9HBG4
AVYLRALVRNLFNEG

ZC3H7A

36

Q8IWR0
KIAVNIALERFRYGD

YTHDC2

46

Q9H6S0
FRNQKILREYRDFLG

SLC30A9

206

Q6PML9
KEFLQLIGYSNFQRV

SEMA3E

711

O15041
IRNILFGAVRGLNYL

STRADB

161

Q9C0K7
ARIRLSFAQVYQGQK

TTC23

186

Q5W5X9
LFNLGSKVLRQYLDA

PIGG

401

Q5H8A4
LGKRTRFQENYVAQL

TTC27

271

Q6P3X3
YEDAVQFIRQKRRGA

PTP4A1

126

Q93096
NVIYLEVQKGQFLRL

SIGLEC11

271

Q96RL6
LKNAIIIQSFIRGYR

UBE3C

46

Q15386
IIQSFIRGYRDRKQQ

UBE3C

51

Q15386
GLLNQNFRKEYRRII

MTNR1A

296

P48039