Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone modifying activity	MED24 RSBN1 SETD2 KMT2B MIER3 NSD3	7.66e-05	229	62	6	GO:0140993
Domain	Rad23	RAD23A RAD23B	1.08e-05	2	62	2	IPR004806
Domain	-	RAD23A RAD23B	1.08e-05	2	62	2	1.10.10.540
Domain	XPC-binding	RAD23A RAD23B	1.08e-05	2	62	2	PF09280
Domain	XPC-bd	RAD23A RAD23B	1.08e-05	2	62	2	IPR015360
Domain	Post-SET_dom	SETD2 KMT2B NSD3	1.89e-05	16	62	3	IPR003616
Domain	PostSET	SETD2 KMT2B NSD3	1.89e-05	16	62	3	SM00508
Domain	POST_SET	SETD2 KMT2B NSD3	1.89e-05	16	62	3	PS50868
Domain	AWS	SETD2 NSD3	1.08e-04	5	62	2	SM00570
Domain	AWS	SETD2 NSD3	1.08e-04	5	62	2	PS51215
Domain	AWS_dom	SETD2 NSD3	1.08e-04	5	62	2	IPR006560
Domain	-	EPPK1 MACF1	1.61e-04	6	62	2	3.90.1290.10
Domain	GAR	GAS2L1 MACF1	1.61e-04	6	62	2	PS51460
Domain	-	GAS2L1 MACF1	1.61e-04	6	62	2	3.30.920.20
Domain	GAS_dom	GAS2L1 MACF1	1.61e-04	6	62	2	IPR003108
Domain	GAS2	GAS2L1 MACF1	1.61e-04	6	62	2	PF02187
Domain	GAS2	GAS2L1 MACF1	1.61e-04	6	62	2	SM00243
Domain	Plectin_repeat	EPPK1 MACF1	2.25e-04	7	62	2	IPR001101
Domain	Plectin	EPPK1 MACF1	2.25e-04	7	62	2	PF00681
Domain	PLEC	EPPK1 MACF1	2.25e-04	7	62	2	SM00250
Domain	SET	SETD2 KMT2B NSD3	3.39e-04	41	62	3	PF00856
Domain	SET	SETD2 KMT2B NSD3	4.78e-04	46	62	3	SM00317
Domain	STI1	RAD23A RAD23B	4.80e-04	10	62	2	SM00727
Domain	STI1_HS-bd	RAD23A RAD23B	4.80e-04	10	62	2	IPR006636
Domain	SET_dom	SETD2 KMT2B NSD3	6.11e-04	50	62	3	IPR001214
Domain	SET	SETD2 KMT2B NSD3	6.11e-04	50	62	3	PS50280
Domain	GrpE_coiled_coil	KRT3 KRT76	7.00e-04	12	62	2	IPR013805
Domain	CH	GAS2L1 CLMN MACF1	1.31e-03	65	62	3	SM00033
Domain	CH	GAS2L1 CLMN MACF1	1.63e-03	70	62	3	PF00307
Domain	-	GAS2L1 CLMN MACF1	1.70e-03	71	62	3	1.10.418.10
Domain	CH	GAS2L1 CLMN MACF1	1.84e-03	73	62	3	PS50021
Domain	CH-domain	GAS2L1 CLMN MACF1	1.98e-03	75	62	3	IPR001715
Domain	Znf_C2H2_jaz	CIZ1 ZNF804A	2.40e-03	22	62	2	IPR022755
Domain	zf-C2H2_jaz	CIZ1 ZNF804A	2.40e-03	22	62	2	PF12171
Domain	Actinin_actin-bd_CS	CLMN MACF1	2.62e-03	23	62	2	IPR001589
Domain	ACTININ_2	CLMN MACF1	2.62e-03	23	62	2	PS00020
Domain	ACTININ_1	CLMN MACF1	2.62e-03	23	62	2	PS00019
Domain	Keratin_2_head	KRT3 KRT76	2.85e-03	24	62	2	IPR032444
Domain	Keratin_2_head	KRT3 KRT76	2.85e-03	24	62	2	PF16208
Domain	PAC	NCOA2 KCNH8	3.35e-03	26	62	2	IPR001610
Domain	Keratin_II	KRT3 KRT76	3.35e-03	26	62	2	IPR003054
Domain	PAC	NCOA2 KCNH8	3.35e-03	26	62	2	SM00086
Domain	UBA	RAD23A RAD23B	4.44e-03	30	62	2	SM00165
Domain	PAS	NCOA2 KCNH8	5.68e-03	34	62	2	IPR000014
Domain	PAS	NCOA2 KCNH8	5.68e-03	34	62	2	PS50112
Domain	UBA	RAD23A RAD23B	6.35e-03	36	62	2	PF00627
Domain	UBIQUITIN_1	RAD23A RAD23B	6.70e-03	37	62	2	PS00299
Domain	UBQ	RAD23A RAD23B	8.97e-03	43	62	2	SM00213
Domain	UBA	RAD23A RAD23B	9.38e-03	44	62	2	IPR015940
Domain	Keratin_I	KRT3 KRT76	9.38e-03	44	62	2	IPR002957
Pathway	WP_GPCRS_OTHER	OR1E1 OR1E2 OR1E3 CASR	2.03e-04	96	43	4	MM15939
Pathway	REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER	UBE2I RAD23A RAD23B	3.00e-04	43	43	3	M1005
Pathway	REACTOME_NUCLEOTIDE_EXCISION_REPAIR	UBE2I PRPF19 RAD23A RAD23B	3.19e-04	108	43	4	M7927
Pathway	REACTOME_NUCLEOTIDE_EXCISION_REPAIR	UBE2I PRPF19 RAD23A RAD23B	3.19e-04	108	43	4	MM15304
Pathway	REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER	UBE2I RAD23A RAD23B	3.43e-04	45	43	3	MM15302
Pathway	REACTOME_PKMTS_METHYLATE_HISTONE_LYSINES	SETD2 KMT2B NSD3	3.66e-04	46	43	3	MM14933
Pathway	REACTOME_JOSEPHIN_DOMAIN_DUBS	RAD23A RAD23B	5.88e-04	12	43	2	M27577
Pathway	REACTOME_JOSEPHIN_DOMAIN_DUBS	RAD23A RAD23B	5.88e-04	12	43	2	MM15288
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	NCOA2 SETD2 KMT2B ERC1 NCAPD2 SEC16A CIZ1 EDC4 EMSY TP53BP1 NSD3	4.80e-09	549	64	11	38280479
Pubmed	Odorant receptors govern the formation of a precise topographic map.	OR1E1 OR1E2 OR1E3	2.37e-08	4	64	3	9546391
Pubmed	Allelic inactivation regulates olfactory receptor gene expression.	OR1E1 OR1E2 OR1E3	5.93e-08	5	64	3	8087849
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	MED24 RSBN1 SETD2 KMT2B MYO5A SCAF8 FBXO28 NCAPD2 CIZ1 MACF1 EDC4 ANKZF1 EMSY NSD3 RAD23B	6.57e-08	1497	64	15	31527615
Pubmed	Mouse-human orthology relationships in an olfactory receptor gene cluster.	OR1E1 OR1E2 OR1E3	3.31e-07	8	64	3	11170746
Pubmed	Identification of potential regulatory motifs in odorant receptor genes by analysis of promoter sequences.	OR1E1 OR1E2 OR1E3	3.31e-07	8	64	3	16902085
Pubmed	Sensitivity-dependent hierarchical receptor codes for odors.	OR1E1 OR1E2 OR1E3	4.95e-07	9	64	3	12588732
Pubmed	Supersensitive detection and discrimination of enantiomers by dorsal olfactory receptors: evidence for hierarchical odour coding.	OR1E1 OR1E2 OR1E3	9.70e-07	11	64	3	26361056
Pubmed	Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire.	OR1E1 OR1E2 OR1E3	9.70e-07	11	64	3	8004088
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	NCOA2 MYO5A ERC1 SEC16A MACF1 WDFY3 EDC4 PEX5L ARHGEF26 EMSY TP53BP1	1.35e-06	963	64	11	28671696
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	MED24 SETD2 KMT2B SCAF8 SEC16A PI4K2A RREB1 EMSY TP53BP1 DHX9	1.44e-06	774	64	10	15302935
Pubmed	Human transcription factor protein interaction networks.	NCOA2 MED24 RSBN1 KMT2B UBE2I MYO5A SCAF8 SEC16A PRPF19 EDC4 RREB1 EMSY TP53BP1	1.68e-06	1429	64	13	35140242
Pubmed	Evolution of odorant receptors expressed in mammalian testes.	OR1E1 OR1E2 OR1E3	1.68e-06	13	64	3	11014824
Pubmed	Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb.	OR1E1 OR1E2 OR1E3	2.13e-06	14	64	3	7528109
Pubmed	Quantitative trait loci for steady-state platelet count in mice.	OR1E1 OR1E2 OR1E3	2.66e-06	15	64	3	15520881
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	NCOA2 MED24 ERC1 SEC16A CIZ1 EDC4 NSD3 RAD23A RAD23B	2.73e-06	645	64	9	25281560
Pubmed	Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.	OR1E1 OR1E2 OR1E3	3.27e-06	16	64	3	10673334
Pubmed	Two mammalian homologs of yeast Rad23, HR23A and HR23B, as multifunctional proteins.	RAD23A RAD23B	3.33e-06	2	64	2	27771451
Pubmed	Chromosomal localization of three repair genes: the xeroderma pigmentosum group C gene and two human homologs of yeast RAD23.	RAD23A RAD23B	3.33e-06	2	64	2	7851894
Pubmed	Rad23 interaction with the proteasome is regulated by phosphorylation of its ubiquitin-like (UbL) domain.	RAD23A RAD23B	3.33e-06	2	64	2	25311859
Pubmed	Olfactory receptors and signalling elements in the Grueneberg ganglion.	OR1E1 OR1E2 OR1E3	3.97e-06	17	64	3	16805845
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	NCOA2 MED24 KMT2B UBE2I PRPF19 EDC4 RREB1 EMSY TP53BP1 RAD23A RAD23B	4.96e-06	1103	64	11	34189442
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	SETD2 CLMN ERC1 SEC16A CIZ1 MACF1 PRPF19 EDC4 EMSY TP53BP1	7.58e-06	934	64	10	33916271
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	EPPK1 CIZ1 EDC4 TP53BP1 NSD3 DHX9 RAD23B	8.09e-06	394	64	7	27248496
Pubmed	Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.	NCOA2 CASR RREB1	8.93e-06	22	64	3	23247143
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	RSBN1 SETD2 SEC16A CIZ1 PRPF19 RREB1 EMSY TP53BP1 NSD3 DHX9	9.11e-06	954	64	10	36373674
Pubmed	3-Methyladenine-DNA glycosylase (MPG protein) interacts with human RAD23 proteins.	RAD23A RAD23B	9.99e-06	3	64	2	10854423
Pubmed	Cloning, comparative mapping, and RNA expression of the mouse homologues of the Saccharomyces cerevisiae nucleotide excision repair gene RAD23.	RAD23A RAD23B	9.99e-06	3	64	2	8808275
Pubmed	Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.	RAD23A RAD23B	9.99e-06	3	64	2	10915768
Pubmed	C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins.	RAD23A RAD23B	9.99e-06	3	64	2	26998601
Pubmed	Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23.	RAD23A RAD23B	9.99e-06	3	64	2	8168482
Pubmed	Involvement of the DNA repair protein hHR23 in p53 degradation.	RAD23A RAD23B	9.99e-06	3	64	2	14645509
Pubmed	Relative levels of the two mammalian Rad23 homologs determine composition and stability of the xeroderma pigmentosum group C protein complex.	RAD23A RAD23B	9.99e-06	3	64	2	15336624
Pubmed	XPC and human homologs of RAD23: intracellular localization and relationship to other nucleotide excision repair complexes.	RAD23A RAD23B	9.99e-06	3	64	2	8692695
Pubmed	Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair.	RAD23A RAD23B	9.99e-06	3	64	2	9371639
Pubmed	Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity.	RAD23A RAD23B	9.99e-06	3	64	2	9372924
Pubmed	Recognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complex.	RAD23A RAD23B	9.99e-06	3	64	2	22431748
Pubmed	NMR characterization of the interaction between the PUB domain of peptide:N-glycanase and ubiquitin-like domain of HR23.	RAD23A RAD23B	9.99e-06	3	64	2	22575648
Pubmed	XPC interacts with both HHR23B and HHR23A in vivo.	RAD23A RAD23B	9.99e-06	3	64	2	9164480
Pubmed	Histone H4K20 Demethylation by Two hHR23 Proteins.	RAD23A RAD23B	9.99e-06	3	64	2	32209475
Pubmed	The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates.	OR1E1 OR1E2 OR1E3	1.03e-05	23	64	3	10706615
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	EPPK1 SCAF8 NCAPD2 MACF1 PRPF19 LRRC40 EDC4 DHX9	1.14e-05	582	64	8	20467437
Pubmed	Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species.	OR1E1 OR1E2 OR1E3	1.17e-05	24	64	3	9119360
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	CNNM3 EPPK1 MYO5A SEC16A CIZ1 MACF1 PRPF19 LRRC40 EDC4 DHX9	1.68e-05	1024	64	10	24711643
Pubmed	Identification of HHR23A as a substrate for E6-associated protein-mediated ubiquitination.	RAD23A RAD23B	2.00e-05	4	64	2	10373495
Pubmed	Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome.	RAD23A RAD23B	2.00e-05	4	64	2	10488153
Pubmed	A functional interaction between RHA and Ubc9, an E2-like enzyme specific for Sumo-1.	UBE2I DHX9	2.00e-05	4	64	2	15312759
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SETD2 KMT2B UBE2I FBXO28 CIZ1 PRPF19 RREB1 EMSY NSD3 DHX9 RAD23B	2.20e-05	1294	64	11	30804502
Pubmed	A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein.	RAD23A RAD23B	3.32e-05	5	64	2	12815074
Pubmed	HHR23A, a human homolog of Saccharomyces cerevisiae Rad23, regulates xeroderma pigmentosum C protein and is required for nucleotide excision repair.	RAD23A RAD23B	3.32e-05	5	64	2	16105547
Pubmed	Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation.	SETD2 NSD3	3.32e-05	5	64	2	39390582
Pubmed	Cloning and characterization of GRIPE, a novel interacting partner of the transcription factor E12 in developing mouse forebrain.	RALGAPA1 UBE2I	3.32e-05	5	64	2	12200424
Pubmed	Regulation of Pax3 by proteasomal degradation of monoubiquitinated protein in skeletal muscle progenitors.	RAD23A RAD23B	3.32e-05	5	64	2	17662948
Pubmed	Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a.	RAD23A RAD23B	3.32e-05	5	64	2	11827521
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	EPPK1 UBE2I NCAPD2 EDC4 RREB1 TP53BP1	3.40e-05	332	64	6	32786267
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	RSBN1 SETD2 ERC1 SEC16A CIZ1 MACF1 WDFY3 RREB1 NSD3 ZNF646	3.49e-05	1116	64	10	31753913
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	MED24 RSBN1 NCAPD2 EDC4 EMSY TP53BP1	3.95e-05	341	64	6	32971831
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	EPPK1 UBE2I MYO5A ERC1 NCAPD2 SEC16A MACF1 PRPF19 DHX9 RAD23B	4.46e-05	1149	64	10	35446349
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	RALGAPA1 ERC1 NCAPD2 SEC16A MACF1 LRRC40 ARHGEF26 DHX9	4.60e-05	708	64	8	39231216
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	RALGAPA1 RSBN1 MYO5A ARRDC1 ERC1 CIZ1 PRPF19 EMSY RAD23B	4.76e-05	925	64	9	28986522
Pubmed	XPC promotes MDM2-mediated degradation of the p53 tumor suppressor.	RAD23A RAD23B	4.98e-05	6	64	2	24258024
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	RALGAPA1 GAS2L1 KRT76 MYO5A CLMN ERC1 SEC16A MACF1 PRPF19 EDC4 DHX9	5.51e-05	1431	64	11	37142655
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	MYO5A CLMN CTNNA3 MACF1 PEX5L	6.86e-05	231	64	5	16452087
Pubmed	Temporal formation of distinct thyroid hormone receptor coactivator complexes in HeLa cells.	NCOA2 MED24	6.96e-05	7	64	2	11117530
Pubmed	A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4.	KMT2B TP53BP1	6.96e-05	7	64	2	19433796
Pubmed	Cross-species divergence of the major recognition pathways of ubiquitylated substrates for ubiquitin/26S proteasome-mediated proteolysis.	RAD23A RAD23B	6.96e-05	7	64	2	20059542
Pubmed	RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation.	UBE2I DHX9	6.96e-05	7	64	2	22162396
Pubmed	RanGAP1*SUMO1 is phosphorylated at the onset of mitosis and remains associated with RanBP2 upon NPC disassembly.	RALGAPA1 UBE2I	6.96e-05	7	64	2	15037602
Pubmed	Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.	KMT2B TP53BP1 RAD23A RAD23B	7.06e-05	119	64	4	23508102
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	MYO5A FAM186A MACF1 PRPF19 DHX9	7.29e-05	234	64	5	36243803
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	RALGAPA1 CNNM3 MYO5A CLMN CIZ1 MACF1 PRPF19 LRRC40 TP53BP1 DHX9 RAD23A	7.76e-05	1487	64	11	33957083
Pubmed	Genetic variations strongly influence phenotypic outcome in the mouse retina.	NCOA2 SOX30 TP53BP1	8.53e-05	46	64	3	21779340
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	NCOA2 SEC16A CIZ1 LRRC40 RREB1 DHX9	9.26e-05	398	64	6	35016035
Pubmed	K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of k29 polyubiquitin.	RAD23A RAD23B	9.27e-05	8	64	2	25752573
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	SETD2 ERC1 SEC16A PRPF19 TP53BP1 RAD23B	9.39e-05	399	64	6	35987950
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	NCOA2 SETD2 ERC1 SEC16A MACF1 EMSY TP53BP1	1.03e-04	588	64	7	38580884
Pubmed	Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome.	PRPF19 TP53BP1 DHX9	1.03e-04	49	64	3	27352031
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RSBN1 SCAF8 ERC1 FBXO28 SEC16A MACF1	1.05e-04	407	64	6	12693553
Pubmed	Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13.	KRT3 KRT76	1.19e-04	9	64	2	15737194
Pubmed	Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks.	UBE2I TP53BP1	1.19e-04	9	64	2	20016603
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	RALGAPA1 CNNM3 PPP3R1 MYO5A ERC1 SEC16A PRPF19 NSD3 PHLPP2	1.24e-04	1049	64	9	27880917
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	KMT2B CIZ1 RREB1 EMSY NSD3 RAD23A RAD23B	1.26e-04	608	64	7	36089195
Pubmed	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.	KRT3 EPPK1 MYO5A SEC16A DHX9	1.28e-04	264	64	5	32814769
Pubmed	The chromosomal distribution of mouse odorant receptor genes.	OR1E1 OR1E2 OR1E3	1.38e-04	54	64	3	8570653
Pubmed	Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.	CNNM3 ERC1 FBXO28 SEC16A PRPF19 WDFY3	1.45e-04	432	64	6	23455922
Pubmed	HIV-1 Vif promotes the G₁- to S-phase cell-cycle transition.	PRPF19 DHX9	1.49e-04	10	64	2	21149631
Pubmed	Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.	CLMN FBXO28 MACF1	1.54e-04	56	64	3	9455484
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	KMT2B SEC16A EMSY DHX9	1.56e-04	146	64	4	23892456
Pubmed	New nomenclature for chromatin-modifying enzymes.	NCOA2 SETD2 KMT2B	1.62e-04	57	64	3	18022353
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	MIER3 TP53BP1 NSD3 RAD23B	1.73e-04	150	64	4	28242625
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	EPPK1 MYO5A NCAPD2 SEC16A MACF1 EDC4 TP53BP1	1.96e-04	653	64	7	22586326
Pubmed	Role of the PLDLS-binding cleft region of CtBP1 in recruitment of core and auxiliary components of the corepressor complex.	UBE2I RREB1	2.17e-04	12	64	2	17967884
Pubmed	Next-generation sequencing to generate interactome datasets.	CNNM3 PPP3R1 UBE2I ARRDC1 FBXO28 SOX30 WDFY3 NSD3 RAD23A	2.41e-04	1147	64	9	21516116
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	EPPK1 SCAF8 ERC1 NCAPD2 SEC16A MACF1 PRPF19 LRRC40 ANKZF1 DHX9	2.46e-04	1415	64	10	28515276
Pubmed	Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.	UBE2I RAD23A RAD23B	2.50e-04	66	64	3	24811749
Pubmed	Defining the membrane proteome of NK cells.	CNNM3 MYO5A NCAPD2 PI4K2A PRPF19 LRRC40 EDC4 ANKZF1 DHX9	2.76e-04	1168	64	9	19946888
Pubmed	TDRD3 promotes DHX9 chromatin recruitment and R-loop resolution.	DHX9 RAD23A	2.99e-04	14	64	2	34329467
Pubmed	PDZK1: I. a major scaffolder in brush borders of proximal tubular cells.	UBE2I SLC22A12	2.99e-04	14	64	2	14531806
Pubmed	An LRP16-containing preassembly complex contributes to NF-κB activation induced by DNA double-strand breaks.	ERC1 DHX9	3.45e-04	15	64	2	25735744
Pubmed	Odorant and vomeronasal receptor genes in two mouse genome assemblies.	OR1E1 OR1E2 OR1E3	3.51e-04	74	64	3	15081110
Interaction	MEA1 interactions	RALGAPA1 NCAPD2 RAD23A RAD23B	1.57e-06	28	62	4	int:MEA1
Interaction	APEX1 interactions	RALGAPA1 RSBN1 SETD2 KMT2B UBE2I MYO5A ARRDC1 ERC1 CIZ1 PRPF19 RREB1 EMSY TP53BP1 NSD3 RAD23B	5.11e-06	1271	62	15	int:APEX1
Interaction	WWTR1 interactions	NCOA2 SETD2 ERC1 NCAPD2 SEC16A EDC4 EMSY TP53BP1	4.35e-05	422	62	8	int:WWTR1
Interaction	MEN1 interactions	MED24 RSBN1 KMT2B NCAPD2 PRPF19 EDC4 EMSY TP53BP1 NSD3 DHX9 RAD23A RAD23B	5.96e-05	1029	62	12	int:MEN1
Interaction	KCNA3 interactions	NCOA2 RALGAPA1 EPPK1 ERC1 NCAPD2 CTNNA3 SEC16A MACF1 LRRC40 ARHGEF26 DHX9	6.22e-05	871	62	11	int:KCNA3
Interaction	POU5F1 interactions	UBE2I SCAF8 ERC1 NCAPD2 LRRC40 EMSY TP53BP1 DHX9 RAD23B	6.99e-05	584	62	9	int:POU5F1
Cytoband	17p13.3	OR1E1 OR1E2 OR1E3	2.61e-04	88	64	3	17p13.3
Cytoband	12p13.3	ERC1 NCAPD2	8.11e-04	30	64	2	12p13.3
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	SETD2 KMT2B NSD3	8.17e-05	34	45	3	487
GeneFamily	Olfactory receptors, family 1	OR1E1 OR1E2 OR1E3	1.33e-04	40	45	3	147
GeneFamily	EF-hand domain containing\|Plakins	EPPK1 MACF1	1.68e-04	8	45	2	939
GeneFamily	EF-hand domain containing\|Nucleotide excision repair\|Transcription and export complex 2	RAD23A RAD23B	9.04e-04	18	45	2	1269
GeneFamily	Keratins, type II	KRT3 KRT76	2.04e-03	27	45	2	609
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	NCOA2 RSBN1 SETD2 PPP3R1 SCAF8 ERC1 MACF1 WDFY3 ZNF804A MBOAT2 TP53BP1 PHLPP2 RAD23B	1.24e-07	856	64	13	M4500
Coexpression	GSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP	RALGAPA1 SETD2 KMT2B ERC1 NCAPD2 MACF1	5.20e-06	180	64	6	M8239
CoexpressionAtlas	DevelopingGonad_e12.5_ovary_emap-28876_k-means-cluster#3_top-relative-expression-ranked_1000	RSBN1 UBE2I CLMN MIER3 WDFY3 NSD3 RAD23B	1.28e-05	277	60	7	gudmap_developingGonad_e12.5_ovary_k3_1000
CoexpressionAtlas	DevelopingGonad_e18.5_ovary_emap-12283_k-means-cluster#2_top-relative-expression-ranked_1000	RSBN1 UBE2I MIER3 WDFY3 NSD3 RAD23B	2.80e-05	210	60	6	gudmap_developingGonad_e18.5_ovary_1000_k2
CoexpressionAtlas	DevelopingGonad_e11.5_ovary + mesonephros_emap-3226_k-means-cluster#4_top-relative-expression-ranked_500	RSBN1 UBE2I WDFY3 NSD3 RAD23B	1.25e-04	172	60	5	gudmap_developingGonad_e11.5_ovary + mesonephros_k4_500
CoexpressionAtlas	DevelopingGonad_e18.5_epididymis_emap-13166_k-means-cluster#3_top-relative-expression-ranked_1000	UBE2I CLMN MIER3 WDFY3 NSD3 RAD23B	1.40e-04	281	60	6	gudmap_developingGonad_e18.5_epididymis_1000_k3
Drug	Sulfacetamide sodic hydrate [6209-17-2]; Up 200; 15.8uM; PC3; HT_HG-U133A	NCOA2 EPPK1 PPP3R1 EMSY NSD3 RAD23B	1.71e-05	193	64	6	1817_UP
Drug	Quinethazone [73-49-4]; Down 200; 13.8uM; PC3; HT_HG-U133A	NCOA2 GAS2L1 PPP3R1 ANKZF1 ARHGEF26 EMSY	1.76e-05	194	64	6	4529_DN
Drug	Hesperidin [520-26-3]; Down 200; 6.6uM; MCF7; HT_HG-U133A	EPPK1 PPP3R1 EDC4 ANKZF1 TP53BP1 RAD23A	1.81e-05	195	64	6	5313_DN
Drug	Chloramphenicol [56-75-7]; Down 200; 12.4uM; HL60; HT_HG-U133A	NCOA2 PPP3R1 UBE2I CIZ1 WDFY3 RAD23B	1.81e-05	195	64	6	1837_DN
Drug	Ticlopidine hydrochloride [53885-35-1]; Down 200; 13.4uM; HL60; HG-U133A	SETD2 PPP3R1 MYO5A MACF1 ANKZF1 RAD23B	1.92e-05	197	64	6	1975_DN
Disease	temporal arteritis	RSBN1 EMSY	3.01e-04	12	64	2	EFO_1001209
Disease	alkaline phosphatase measurement	NCOA2 RALGAPA1 MED24 RSBN1 MACF1 RREB1 VWDE TP53BP1 PHLPP2	3.28e-04	1015	64	9	EFO_0004533
Disease	malignant pleural mesothelioma (is_marker_for)	NCOA2 SETD2	4.14e-04	14	64	2	DOID:7474 (is_marker_for)
Disease	Dystonia, Limb	KMT2B CIZ1	6.17e-04	17	64	2	C0751093
Disease	Dystonia, Diurnal	KMT2B CIZ1	6.17e-04	17	64	2	C0393610
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	SETD2 KMT2B	6.17e-04	17	64	2	DOID:0060307 (is_implicated_in)
Disease	syndrome (implicated_via_orthology)	SCAF8 NSD3	6.93e-04	18	64	2	DOID:225 (implicated_via_orthology)
Disease	Dystonia, Paroxysmal	KMT2B CIZ1	6.93e-04	18	64	2	C0393588
Disease	rheumatoid arthritis, ulcerative colitis	RSBN1 EMSY	9.47e-04	21	64	2	EFO_0000685, EFO_0000729
Disease	Malignant neoplasm of breast	NCOA2 SETD2 KRT76 MACF1 KLHDC7A EMSY TP53BP1 ZNF646	2.18e-03	1074	64	8	C0006142
Disease	Drugs used in diabetes use measurement	CTNNA3 MACF1 CASR RREB1	2.31e-03	255	64	4	EFO_0009924
Disease	hyperuricemia	RREB1 SLC22A12	2.34e-03	33	64	2	EFO_0009104
Disease	calcium measurement	CNNM3 MACF1 CASR RREB1 RNF217 MBOAT2	2.39e-03	628	64	6	EFO_0004838
Disease	total blood protein measurement	NCOA2 SETD2 SEC16A MACF1 RREB1	2.91e-03	449	64	5	EFO_0004536
Disease	Sclerocystic Ovaries	KRT3 EMSY BMP15	3.82e-03	144	64	3	C1136382
Disease	Polycystic Ovary Syndrome	KRT3 EMSY BMP15	3.82e-03	144	64	3	C0032460

Protein segments in the cluster

Peptide	Gene	Start	Entry
QQQEEPPLLELKQEQ	ESX1	96	Q8N693
LAQLLQLVQQGQELP	C6orf226	21	Q5I0X4
QPERQKQQQPLALTQ	CASR	926	P41180
EDQQRTININPPQEI	C14orf28	166	Q4W4Y0
PLQRLPSQENELLEN	ARHGEF26	216	Q96DR7
LPELQQNPLVQRVID	PPP3R1	46	P63098
LNLNSIPDIEQPNVA	ARRDC1	136	Q8N5I2
PALLQQLGQENPQLL	RAD23A	256	P54725
IIQQNPSLLPALLQQ	RAD23B	291	P54727
PDQIIQPLLELDQNR	ERC1	1006	Q8IUD2
LQDVQIRFQPQLNPD	EDC4	516	Q6P2E9
FQVLQLPQALPIQVD	PCDH12	66	Q9NPG4
NQSLLQPLNVEIDPQ	KRT76	161	Q01546
LLQPLSNAVQLPIDQ	MBOAT2	11	Q6ZWT7
NQSLLQPLNVEIDPQ	KRT3	176	P12035
QNLINQLVDQSVPRP	BMP15	341	O95972
QLVNEQQESRPLLSP	PEX5L	66	Q8IYB4
LPEVVPLLNRDQNQA	LRRC37B	131	Q96QE4
PLLNRDQNQALVQLP	LRRC37B	136	Q96QE4
QEEAPAQLLQLPQEV	LRRC37B	281	Q96QE4
AQLLQLPQEVEPSTQ	LRRC37B	286	Q96QE4
QLLQPLQALQTQLLP	KMT2B	736	Q9UMN6
NRPEPIPDQQLNILN	MIER3	376	Q7Z3K6
NQIIISQPQEVPAQL	MACF1	3431	Q9UPN3
PLPENTNRQLLLQFE	PI4K2A	281	Q9BTU6
ELPSNDQLQQEEPPI	PAGE3	31	Q5JUK9
PINNQPLSEEQLIDI	PRPF19	41	Q9UMS4
GLQTLLQQLPPQDID	PRICKLE4	26	Q2TBC4
PITLNIDPQDLQVQT	CTNNA3	6	Q9UI47
QDPPEEAELLLQNLQ	ANKZF1	186	Q9H8Y5
PLQLDPQQEQQLFRR	GAS2L1	506	Q99501
DQLPQNNTLVALPIV	FBXO28	56	Q9NVF7
QPAPEENDQLQFVLQ	MS4A14	171	Q96JA4
LLQIAENPELQLQPD	KLHDC7A	366	Q5VTJ3
QQKLSQPPLEQTQLQ	EMSY	951	Q7Z589
QPPLEQTQLQVKTLQ	EMSY	956	Q7Z589
LQQAQELGIPLTPQQ	FAM186A	1101	A6NE01
QELEIPLTPQQAQAL	FAM186A	1561	A6NE01
LPLPDTIQDVQNQAV	SLC22A12	521	Q96S37
RQQLLEQQQPQKATP	SCAF8	316	Q9UPN6
LQNIIQELNLEILPP	DHX9	286	Q08211
TLDLQNNDLLQIPPE	LRRC40	546	Q9H9A6
DFLLLGLPIQPEQQN	OR1E2	11	P47887
EFLLLGLPIQPEQQN	OR1E3	11	Q8WZA6
DFLLLGLPIQPEQQN	OR1E1	11	P30953
LNLQQDQKTQPIPVL	RSBN1	766	Q5VWQ0
LVPQNEGLPLLQVQL	EPPK1	1346	P58107
ANIQPNIQLILRAEP	MED24	401	O75448
LNPQTLPLQLELEEE	RNF217	96	Q8TC41
PEQQEGQLELPEQQE	IVL	176	P07476
PEQQEGQLELPEQQE	IVL	186	P07476
PEQQEGQLELPEQQE	IVL	196	P07476
PEQQEGQLELPEQQE	IVL	206	P07476
PEQQEGQLELPEQQE	IVL	216	P07476
PEQQEGQLELPQQQE	IVL	226	P07476
QEAQLELPEQQVGQP	IVL	486	P07476
EQVLLLPQPQAQNEE	SOX30	76	O94993
SPNLENIANPLEENV	CLMN	841	Q96JQ2
QQLLQLPQGEEEIPE	NCAPD2	491	Q15021
QGPRQVQLQQEAEPL	CIZ1	386	Q9ULV3
VQLQQEAEPLKQVQP	CIZ1	391	Q9ULV3
QNLPQSPENTDLQVI	CNNM3	656	Q8NE01
LLPNQNLPLDITLQS	NCOA2	881	Q15596
ENNQPPVIQALQDKL	VWDE	1091	Q8N2E2
IQELLNEPNIQDPAQ	UBE2I	116	P63279
LQQPVSELPENLQVS	WDFY3	1781	Q8IZQ1
DNLINPPLNLQETQV	RALGAPA1	171	Q6GYQ0
NNISIFPEILQLPQI	PHLPP2	701	Q6ZVD8
QNQEVLPSEPLNLDP	SEC16A	466	O15027
EEPLPDDNQAIQLQT	RREB1	381	Q92766
PPLQLSEAELLNQLQ	ZNF646	931	O15015
DDPLRLDQELQQPQT	TP53BP1	841	Q12888
IQQPPQLIDSANIRQ	NSD3	16	Q9BZ95
EELQSQQLLPQQLPE	SETD2	1921	Q9BYW2
QRELQLQQLEQQPEP	ZNF853	86	P0CG23
QQQEVQLELTPVQPE	ZNF853	396	P0CG23
QLELTPVQPELQLEL	ZNF853	401	P0CG23
NPDQPAVILLLRQVQ	TTC37	1356	Q6PGP7
ENINLNEKQIPFQVP	ZNF804A	941	Q7Z570
VIQLLENVLSPQQPS	KCNH8	891	Q96L42
QQQLLAQNLQLPPEA	MYO5A	1381	Q9Y4I1