Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionstructural molecule activity

VWF KRT31 KRT32 KRT35 CLDN4 CLDN19 KRTAP16-1 MUC4 SSPOP AGRN FBN3

2.59e-058915511GO:0005198
GeneOntologyMolecularFunctionextracellular matrix structural constituent

VWF MUC4 SSPOP AGRN FBN3

1.67e-04188555GO:0005201
GeneOntologyCellularComponentextracellular matrix

NTN4 VWF ZAN ADAMTS3 NDP MUC4 SSPOP AGRN FBN3

4.89e-05656559GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

NTN4 VWF ZAN ADAMTS3 NDP MUC4 SSPOP AGRN FBN3

5.00e-05658559GO:0030312
GeneOntologyCellularComponentintermediate filament

KRT31 KRT32 KRT35 KRTAP10-10 KRTAP16-1

3.23e-04227555GO:0005882
GeneOntologyCellularComponentcollagen-containing extracellular matrix

NTN4 VWF ADAMTS3 NDP MUC4 SSPOP AGRN

4.58e-04530557GO:0062023
GeneOntologyCellularComponentintermediate filament cytoskeleton

KRT31 KRT32 KRT35 KRTAP10-10 KRTAP16-1

6.32e-04263555GO:0045111
DomainVWFD

VWF ZAN MUC4 SSPOP

1.11e-0716544PS51233
DomainVWD

VWF ZAN MUC4 SSPOP

1.11e-0716544SM00216
DomainVWF_type-D

VWF ZAN MUC4 SSPOP

1.11e-0716544IPR001846
DomainVWD

VWF ZAN MUC4 SSPOP

1.11e-0716544PF00094
DomainBBOX

TRIM49 TRIM51 TRIM49C TRIM49D1 TRIM49B

1.63e-0669545SM00336
DomainButyrophylin

TRIM49 TRIM51 TRIM49C TRIM49D1 TRIM49B

1.75e-0670545IPR003879
Domain-

TRIM49 TRIM51 TRIM49C TRIM49D1 TRIM49B

1.88e-06715454.10.45.10
Domainzf-B_box

TRIM49 TRIM51 TRIM49C TRIM49D1 TRIM49B

2.02e-0672545PF00643
DomainConA-like_dom

TRIM49 TRIM51 ZAN TRIM49C TRIM49D1 TRIM49B AGRN

3.07e-06219547IPR013320
DomainZF_BBOX

TRIM49 TRIM51 TRIM49C TRIM49D1 TRIM49B

3.41e-0680545PS50119
DomainVWFC_1

VWF ZAN CHRDL1 SSPOP

3.43e-0636544PS01208
DomainZnf_B-box

TRIM49 TRIM51 TRIM49C TRIM49D1 TRIM49B

3.62e-0681545IPR000315
DomainVWC

VWF ZAN CHRDL1 SSPOP

4.28e-0638544SM00214
DomainVWFC_2

VWF ZAN CHRDL1 SSPOP

4.28e-0638544PS50184
DomainTIL

VWF ZAN SSPOP

4.93e-0612543PF01826
DomainC8

VWF ZAN SSPOP

4.93e-0612543PF08742
DomainUnchr_dom_Cys-rich

VWF ZAN SSPOP

6.40e-0613543IPR014853
DomainC8

VWF ZAN SSPOP

6.40e-0613543SM00832
DomainVWF_dom

VWF ZAN CHRDL1 SSPOP

6.44e-0642544IPR001007
DomainSPRY

TRIM49 TRIM51 TRIM49C TRIM49D1 TRIM49B

7.55e-0694545PF00622
DomainSPRY_dom

TRIM49 TRIM51 TRIM49C TRIM49D1 TRIM49B

7.55e-0694545IPR003877
DomainB30.2/SPRY

TRIM49 TRIM51 TRIM49C TRIM49D1 TRIM49B

7.95e-0695545IPR001870
DomainB302_SPRY

TRIM49 TRIM51 TRIM49C TRIM49D1 TRIM49B

7.95e-0695545PS50188
DomainTIL_dom

VWF ZAN SSPOP

8.13e-0614543IPR002919
DomainEGF_1

NTN4 ZAN DLL1 MUC4 SSPOP AGRN FBN3

8.35e-06255547PS00022
DomainCTCK_1

VWF NDP SSPOP

1.81e-0518543PS01185
DomainVWC_out

VWF ZAN SSPOP

2.14e-0519543SM00215
DomainEGF

ZAN DLL1 MUC4 AGRN FBN3

3.13e-05126545PF00008
DomainCys_knot_C

VWF NDP SSPOP

5.02e-0525543IPR006207
DomainCTCK_2

VWF NDP SSPOP

5.02e-0525543PS01225
DomainEGF_3

ZAN DLL1 MUC4 SSPOP AGRN FBN3

5.80e-05235546PS50026
DomainEGF-like_CS

NTN4 ZAN DLL1 MUC4 AGRN FBN3

1.04e-04261546IPR013032
DomainEGF_2

ZAN DLL1 MUC4 SSPOP AGRN FBN3

1.13e-04265546PS01186
DomainSPRY

TRIM49 TRIM49C TRIM49D1 TRIM49B

1.16e-0487544SM00449
DomainPEROXIDASE_1

MPO EPX

1.22e-046542PS00435
DomainZF_RING_2

TRIM49 TRAF4 TRIM51 TRIM49C TRIM49D1 TRIM49B

2.13e-04298546PS50089
DomainRING

TRIM49 TRAF4 TRIM51 TRIM49C TRIM49D1 TRIM49B

2.41e-04305546SM00184
DomainKeratin_I

KRT31 KRT32 KRT35

2.78e-0444543IPR002957
DomainZnf_RING

TRIM49 TRAF4 TRIM51 TRIM49C TRIM49D1 TRIM49B

3.45e-04326546IPR001841
DomainHaem_peroxidase

MPO EPX

3.64e-0410542IPR010255
DomainAn_peroxidase

MPO EPX

3.64e-0410542PF03098
DomainPEROXIDASE_3

MPO EPX

3.64e-0410542PS50292
Domain-

MPO EPX

3.64e-04105421.10.640.10
DomainHaem_peroxidase_animal

MPO EPX

3.64e-0410542IPR019791
DomainEGF

ZAN DLL1 MUC4 AGRN FBN3

5.78e-04235545SM00181
DomainEGF-like_dom

ZAN DLL1 MUC4 AGRN FBN3

7.51e-04249545IPR000742
DomainIntermediate_filament_CS

KRT31 KRT32 KRT35

8.03e-0463543IPR018039
DomainGrowth_fac_rcpt_

NTN4 KRT32 DLL1 FBN3

1.07e-03156544IPR009030
DomainFilament

KRT31 KRT32 KRT35

1.14e-0371543SM01391
DomainIF

KRT31 KRT32 KRT35

1.18e-0372543PS00226
DomainFilament

KRT31 KRT32 KRT35

1.23e-0373543PF00038
DomainIF

KRT31 KRT32 KRT35

1.38e-0376543IPR001664
DomainZF_RING_1

TRIM49 TRAF4 TRIM51 TRIM49C TRIM49B

1.50e-03291545PS00518
Domain-

TRIM49 TRAF4 TRIM51 TRIM49C TRIM49D1 TRIM49B

1.82e-034495463.30.40.10
DomainCT

VWF NDP

1.83e-0322542SM00041
DomainClaudin_CS

CLDN4 CLDN19

1.83e-0322542IPR017974
DomainCLAUDIN

CLDN4 CLDN19

1.83e-0322542PS01346
DomainZnf_RING/FYVE/PHD

TRIM49 TRAF4 TRIM51 TRIM49C TRIM49D1 TRIM49B

2.03e-03459546IPR013083
DomainTIMP-like_OB-fold

NTN4 AGRN

2.55e-0326542IPR008993
DomainClaudin

CLDN4 CLDN19

2.96e-0328542IPR006187
DomainhEGF

DLL1 FBN3

2.96e-0328542PF12661
DomainVWC

VWF CHRDL1

2.96e-0328542PF00093
DomainEGF_LAM_2

NTN4 AGRN

3.39e-0330542PS50027
DomainEGF_LAM_1

NTN4 AGRN

3.39e-0330542PS01248
DomainLaminin_EGF

NTN4 AGRN

4.59e-0335542PF00053
DomainEGF_Lam

NTN4 AGRN

4.59e-0335542SM00180
DomainEGF_CA

DLL1 AGRN FBN3

5.29e-03122543SM00179
DomainLaminin_EGF

NTN4 AGRN

5.40e-0338542IPR002049
DomainEGF-like_Ca-bd_dom

DLL1 AGRN FBN3

5.54e-03124543IPR001881
DomainKeratin_B2_2

KRTAP10-10 KRTAP16-1

5.68e-0339542PF13885
DomainPMP22_Claudin

CLDN4 CLDN19

5.97e-0340542PF00822
DomainPMP22/EMP/MP20/Claudin

CLDN4 CLDN19

7.50e-0345542IPR004031
PathwayREACTOME_KERATINIZATION

KRT31 KRT32 KRT35 KRTAP10-10 KRTAP16-1 LCE3B

1.64e-05217366M27640
PathwayREACTOME_KERATINIZATION

KRT31 KRT32 KRT35 KRTAP10-10 KRTAP16-1

4.05e-05153365MM15343
PathwayREACTOME_ENHANCED_BINDING_OF_GP1BA_VARIANT_TO_VWF_MULTIMER_COLLAGEN

VWF GP5

1.32e-047362M48265
PathwayREACTOME_DEFECTS_OF_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN

VWF GP5

1.76e-048362M48236
PathwayREACTOME_DEVELOPMENTAL_BIOLOGY

NTN4 KRT31 KRT32 KRT35 KRTAP10-10 ARHGAP35 KRTAP16-1

2.37e-04502367MM14537
PathwayREACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE

KRT31 KRT32 KRT35 LCE3B

3.14e-04129364M27649
PathwayREACTOME_GP1B_IX_V_ACTIVATION_SIGNALLING

VWF GP5

4.12e-0412362MM15093
PathwayREACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN

VWF GP5

4.12e-0412362MM15452
PathwayREACTOME_GP1B_IX_V_ACTIVATION_SIGNALLING

VWF GP5

4.12e-0412362M27352
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

ADAMTS3 MUC4 SSPOP AGRN

4.65e-04143364M27275
PathwayREACTOME_DEVELOPMENTAL_BIOLOGY

NTN4 KRT31 KRT32 KRT35 KRTAP10-10 ARHGAP35 DLL1 KRTAP16-1 AGRN DPPA3 LCE3B

6.23e-0414323611M509
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTS3 MUC4 SSPOP

6.84e-0468363M27303
PathwayREACTOME_DEFECTS_OF_CONTACT_ACTIVATION_SYSTEM_CAS_AND_KALLIKREIN_KININ_SYSTEM_KKS

VWF GP5

7.44e-0416362M38996
PathwayREACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN

VWF GP5

7.44e-0416362M9450
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

NTN4 VWF ADAMTS3 AGRN FBN3

9.26e-04300365M610
PathwayREACTOME_DISEASES_OF_HEMOSTASIS

VWF GP5

1.06e-0319362M48230
PathwayKEGG_ECM_RECEPTOR_INTERACTION

VWF AGRN GP5

1.26e-0384363M7098
PathwayREACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE

KRT31 KRT32 KRT35

1.40e-0387363MM15351
PathwayREACTOME_INTRINSIC_PATHWAY_OF_FIBRIN_CLOT_FORMATION

VWF GP5

1.55e-0323362M14766
PathwayREACTOME_INTRINSIC_PATHWAY_OF_FIBRIN_CLOT_FORMATION

VWF GP5

1.55e-0323362MM14557
PathwayREACTOME_TIGHT_JUNCTION_INTERACTIONS

CLDN4 CLDN19

2.64e-0330362M17967
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS3 MUC4 SSPOP

2.67e-03109363MM15164
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS3 MUC4 SSPOP

2.81e-03111363M27416
PathwayKEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION

CLDN4 CLDN19 ARHGAP35

3.18e-03116363M2164
Pubmed

Identification of a genomic reservoir for new TRIM genes in primate genomes.

TRIM49 TRIM51 TRIM49C TRIM49D1 TRIM49B

1.03e-101956522144910
Pubmed

Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos.

TRIM49 TRIM51 TRIM49C TRIM49B

8.12e-091556419703589
Pubmed

Lineage-specific biology revealed by a finished genome assembly of the mouse.

TRIM49 TRIM51 TRIM49C KRTAP16-1 TRIM49B

2.95e-085556519468303
Pubmed

Human hair keratins.

KRT31 KRT32 KRT35

3.30e-0795637686952
Pubmed

The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle.

KRT31 KRT32 KRT35

4.71e-071056310391933
Pubmed

Uncovering a new role for peroxidase enzymes as drivers of angiogenesis.

MPO EPX

2.55e-06256226386352
Pubmed

On the regulation of hair keratin expression: lessons from studies in pilomatricomas.

KRT31 KRT35

2.55e-06256215140206
Pubmed

Inflammatory peroxidases promote breast cancer progression in mice via regulation of the tumour microenvironment.

MPO EPX

2.55e-06256228260049
Pubmed

Peroxidase enzymes inhibit osteoclast differentiation and bone resorption.

MPO EPX

2.55e-06256227836774
Pubmed

Hereditary eosinophil peroxidase deficiency: immunochemical and spectroscopic studies and evidence for a compound heterozygosity of the defect.

MPO EPX

2.55e-0625627809065
Pubmed

The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice.

KRT31 KRT32 KRT35

5.15e-062156319470461
Pubmed

Thiocyanate modulates the catalytic activity of mammalian peroxidases.

MPO EPX

7.63e-06356215894800
Pubmed

The evolutionary conservation of the mammalian peroxidase genes.

MPO EPX

7.63e-06356212584448
Pubmed

The potential for repositioning antithyroid agents as antiasthma drugs.

MPO EPX

7.63e-06356227444178
Pubmed

The eosinophil peroxidase gene forms a cluster with the genes for myeloperoxidase and lactoperoxidase on human chromosome 17.

MPO EPX

7.63e-06356210828600
Pubmed

Peroxidasin and eosinophil peroxidase, but not myeloperoxidase, contribute to renal fibrosis in the murine unilateral ureteral obstruction model.

MPO EPX

7.63e-06356230565999
Pubmed

Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5.

KRT32 KRT35

7.63e-0635628823373
Pubmed

Key role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow.

VWF GP5

2.54e-05556221037087
Pubmed

Eosinophil peroxidase activates cells by HER2 receptor engagement and β1-integrin clustering with downstream MAPK cell signaling.

EPX MUC4

2.54e-05556227519953
Pubmed

Whn and mHa3 are components of the genetic hierarchy controlling hair follicle differentiation.

KRT31 KRT32

3.80e-05656210559501
Pubmed

Phosphoinositide 3-kinase forms a complex with platelet membrane glycoprotein Ib-IX-V complex and 14-3-3zeta.

VWF GP5

5.32e-05756210887121
Pubmed

von Willebrand factor binding to platelet GpIb initiates signals for platelet activation.

VWF GP5

5.32e-0575621939645
Pubmed

Characterization of a 190-kilobase pair domain of human type I hair keratin genes.

KRT31 KRT35

9.10e-0595629756910
Pubmed

Spatiotemporal expression pattern of keratins in skin of AP-2alpha-deficient mice.

KRT31 KRT32

1.14e-041056210571739
Pubmed

TBL2, a novel transducin family member in the WBS deletion: characterization of the complete sequence, genomic structure, transcriptional variants and the mouse ortholog.

ZAN CLDN4

1.39e-041156210575226
Pubmed

New consensus nomenclature for mammalian keratins.

KRT31 KRT32 KRT35

1.47e-046356316831889
Pubmed

Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.

ADAMTS3 SSPOP AGRN

1.54e-046456322261194
Pubmed

Genome-wide association study of sex hormones, gonadotropins and sex hormone-binding protein in Chinese men.

ARMC9 ZFPM1

1.66e-041256224049095
Pubmed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

VWF MUC4 SSPOP AGRN

1.85e-0417556428071719
Pubmed

Quantitative trait loci for steady-state platelet count in mice.

KRT32 EPX

2.64e-041556215520881
Pubmed

The genomic organization of type I keratin genes in mice.

KRT31 KRT32

2.64e-041556210087197
Pubmed

Human chromosome 11 DNA sequence and analysis including novel gene identification.

TRIM49 TRIM49C TRIM49D1

2.98e-048056316554811
Pubmed

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

MPO KRT31 KRT32 KRT35 EPX MUC4 AGRN GP5

3.00e-04107056823533145
Pubmed

A 5' untranslated region containing the IRES element in the Runx1 gene is required for angiogenesis, hematopoiesis and leukemogenesis in a knock-in mouse model.

MPO ZFPM1

3.01e-041656220647008
Pubmed

Dysplastic definitive hematopoiesis in AML1/EVI1 knock-in embryos.

MPO ZFPM1

3.01e-041656215914564
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

TRAF4 KMT5C ZBTB4 CLDN4 ZFPM1 ARHGAP35 DLL1 AGRN

3.72e-04110556835748872
Pubmed

Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function.

CLDN4 CLDN19

4.28e-041956222155109
Pubmed

Biology of claudins.

CLDN4 CLDN19

4.28e-041956218480174
Pubmed

Assessment of community efforts to advance network-based prediction of protein-protein interactions.

KRT31 KRT32 ARMC12 KRT35 KRTAP10-10 LCE3B

5.19e-0463056636949045
Pubmed

Tight junction proteins.

CLDN4 CLDN19

5.24e-042156212475568
Pubmed

Multifunctional strands in tight junctions.

CLDN4 CLDN19

5.24e-042156211283726
Pubmed

Claudin-based barrier in simple and stratified cellular sheets.

CLDN4 CLDN19

5.24e-042156212231346
Pubmed

Tight junctions of the blood-brain barrier.

CLDN4 CLDN19

5.24e-042156210690502
Pubmed

The roles of claudin superfamily proteins in paracellular transport.

CLDN4 CLDN19

5.24e-042156211247307
Pubmed

Structure and function of claudins.

CLDN4 CLDN19

6.30e-042356218036336
Pubmed

The claudins.

CLDN4 CLDN19

6.30e-042356219706201
Pubmed

E-cadherin is required for intestinal morphogenesis in the mouse.

CLDN4 MUC4

6.87e-042456222766025
Pubmed

Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18.

CLDN4 LCE3B

7.46e-042556223132931
Pubmed

Holoprosencephaly Overview

STIL DLL1

7.46e-042556220301702
Pubmed

Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium.

KRT35 LCE3B

8.07e-042656215454262
Pubmed

Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation.

CLDN4 CLDN19

8.07e-042656222275141
Pubmed

Fine-scale comparative mapping of the human 7q11.23 region and the orthologous region on mouse chromosome 5G: the low-copy repeats that flank the Williams-Beuren syndrome deletion arose at breakpoint sites of an evolutionary inversion(s).

ZAN CLDN4

1.46e-033556211013070
InteractionKRT78 interactions

KRT31 KRT32 KRT35 STIL AGRN

2.43e-0687505int:KRT78
InteractionHOXA1 interactions

NTN4 TRAF4 VWF KRT31 KRT35 KRTAP10-10 ODF1 AGRN

2.46e-06356508int:HOXA1
InteractionKRT86 interactions

KRT31 KRT32 KRT35 ODF1

3.58e-0575504int:KRT86
InteractionLCE1C interactions

NTN4 KRTAP10-10 ODF1 LCE3B

3.97e-0577504int:LCE1C
InteractionKRT76 interactions

KRT31 KRT32 KRT35 DPPA3

5.59e-0584504int:KRT76
Cytoband17q21.2

KRT32 KRT35 KRTAP16-1

9.36e-057057317q21.2
Cytoband17q23.1

MPO EPX

1.80e-041657217q23.1
Cytoband11q14.3

TRIM49C TRIM49D1

7.33e-043257211q14.3
CytobandEnsembl 112 genes in cytogenetic band chr11q14

TRIM49 TRIM49C TRIM49D1

9.84e-04156573chr11q14
CytobandEnsembl 112 genes in cytogenetic band chr17q21

KRT31 KRT32 KRT35 KRTAP16-1

2.86e-03473574chr17q21
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

TRIM49 TRIM51 TRIM49C TRIM49D1 TRIM49B

1.58e-069538559
GeneFamilyRing finger proteins

TRIM49 TRAF4 TRIM51 TRIM49C TRIM49D1 TRIM49B

2.15e-0527538658
GeneFamilyKeratins, type I

KRT31 KRT32 KRT35

2.71e-0528383608
GeneFamilyClaudins

CLDN4 CLDN19

1.06e-0323382488
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

ARMC12 ARMC9

3.68e-0343382409
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-6|TCGA-Skin / Sample_Type by Project: Shred V9

KRT31 KRT32 KRT35 KRTAP10-10 KRTAP16-1

1.23e-06146575522c32103c24fc26836bb5b642083904682d9292
ToppCell3'-Child09-12-SmallIntestine-Epithelial-goblet|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NTN4 CLDN4 DLL1 MUC4 ABHD17C

5.19e-06196575c2d17630f7bfc9e727de55e093c17fddac61b61f
ToppCell3'-Child09-12-SmallIntestine-Epithelial-goblet-Goblet_cell|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NTN4 CLDN4 DLL1 MUC4 ABHD17C

5.19e-0619657554c30023d04e7265373647f56fc93885804938b0
ToppCellPosterior_cortex-Macroglia-ASTROCYTE|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

CHRDL1 NDP CLDN19 TTLL8

1.30e-051125741c0bcc6c972c50a9d950cd56b65efb8d778ec25a
ToppCellPosterior_cortex-Macroglia-ASTROCYTE-Gja1|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

CHRDL1 NDP CLDN19 TTLL8

1.30e-05112574e30cd0b7b755c63081bbeed4e1a884b6640d34f8
ToppCellTCGA-Testes-Primary_Tumor-Testicular_Germ_Cell_Tumor-Non-Seminoma-_Embryonal_Carcinoma|TCGA-Testes / Sample_Type by Project: Shred V9

TRIM49 TRIM51 TRIM49B MUC4

3.03e-051395746b58d01ce9d9ac23434333f9faf1bb0eef14ba90
ToppCelldroplet-Marrow-BM-30m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF IGFLR1 TLR8 DYRK3

5.51e-0516257475df7ff779a3b9159ba97d852da1f8df650b9ce5
ToppCell5'-Adult-LargeIntestine-Epithelial-goblet-Goblet_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CLDN4 IQCN DLL1 MUC4

6.80e-0517157448125d825ca2d7ef34564250f5b47d2a579e03c9
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-5_RORB_CD24|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS3 KRT31 KRT32 KRT35

7.27e-051745743e29d620b7b4ab1915ddac70ee5a50d09072292b
ToppCellwk_20-22-Epithelial-Proximal_epithelial-basal_proximal|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

KRT31 KRT32 CLDN4 MUC4

7.94e-051785749534c4f4e950bb1498c1737ca1713e7f37d0aff2
ToppCelldroplet-Limb_Muscle-Pre-Sort|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF CHRDL1 CLDN4 CLDN19

8.29e-05180574af2bafcd1b2082629de3ea336711add01565c4c4
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF CHRDL1 CLDN4 CLDN19

8.29e-05180574f29a995cf6e1a1836ed68b73258d9370bf3d4434
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CHRDL1 ZFPM1 DLL1 AGRN

9.41e-0518657410565fce7e1b4ec88bc8e1ed6410a83800be5014
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-goblet|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDXDC1 NTN4 CLDN4 MUC4

1.09e-04193574402aad2f9e789ad1f2e1536cdc9ce61de7625427
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDXDC1 NTN4 CLDN4 MUC4

1.09e-041935747ee3b1ef5c455f321b4e154ae62c69543fe9b30e
ToppCellCTRL-Epithelial-Epithelial_cell|CTRL / Disease state, Lineage and Cell class

TRAF4 CLDN4 MUC4 ABHD17C

1.11e-041945742bc4deaf2a01a39809fc323962fce4286835209c
ToppCell3'-Child04-06-SmallIntestine-Epithelial-goblet-Goblet_cell|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NTN4 CLDN4 MUC4 ABHD17C

1.11e-0419457449cc5f5de4380302100e8cd937f08abe317ac75e
ToppCell3'-Child04-06-SmallIntestine-Epithelial-goblet|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NTN4 CLDN4 MUC4 ABHD17C

1.11e-04194574fb935df966c451e659b8bde281f8aebcb632f6cf
ToppCellCTRL-Epithelial|CTRL / Disease state, Lineage and Cell class

TRAF4 CLDN4 MUC4 ABHD17C

1.11e-0419457449dcb31427f370692308f939e23992925708abb7
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-goblet|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDXDC1 NTN4 CLDN4 MUC4

1.13e-0419557409605533aa5947bb2e5a6725c1ce89f79d330bf5
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDXDC1 NTN4 CLDN4 MUC4

1.13e-041955747ff04c45a02df01e3816f3c1d43585a93182a730
ToppCell343B|World / Donor, Lineage, Cell class and subclass (all cells)

VWF ARMC9 CLDN4 MUC4

1.13e-041955742290911fde6efacfa38b985a2541322968bee42d
ToppCellwk_20-22-Epithelial-Distal_epithelial|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CLDN4 CLDN19 AGRN FBN3

1.15e-04196574cd507ee2baf4f52d6498811b3510d3164b56311f
ToppCellwk_20-22-Epithelial-Distal_epithelial-type_I_pneumocyte|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CLDN4 CLDN19 AGRN FBN3

1.15e-04196574e24a7aaf41793abba66c1189d933ca05b14c1af9
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IRF2BP2 CLDN4 MUC4 ABHD17C

1.17e-04197574233b9fcb376e08d0080a05ca0198ecc6ec720f90
ToppCellcellseq2-Epithelial-Epithelial_Glandular-SMG_Basal/Duct-SMG_Basal/Duct|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TRAF4 CLDN4 MUC4 AGRN

1.20e-04198574829377071f65016d31d09175a43c28e95532b404
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Epithelial|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

TRAF4 CLDN4 MUC4 ABHD17C

1.20e-04198574fb3965049cb1961de0d2e74370868e46aa5050c8
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

TRAF4 CLDN4 MUC4 ABHD17C

1.20e-041985749f5726aedd1fb132feab717a029fa302306461b5
ToppCell3'-GW_trimst-1-SmallIntestine-Epithelial-goblet|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NTN4 CLDN4 DLL1 MUC4

1.20e-041985749c5d7852f03468394e726c444cac92a043fc6d0e
ToppCellcellseq2-Epithelial-Epithelial_Glandular-SMG_Basal/Duct|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TRAF4 CLDN4 MUC4 AGRN

1.20e-0419857427a3c1c5ac855dff8d63f44eaa289be3f5bd621a
ToppCell3'-GW_trimst-1-SmallIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NTN4 CLDN4 DLL1 MUC4

1.20e-04198574f95f38cc747fb3549a791288bf8d0518c049ac96
ToppCelltumor_Lung-Epithelial_cells-tS2|tumor_Lung / Location, Cell class and cell subclass

TRAF4 CLDN4 MUC4 AGRN

1.22e-0419957428ec59e01061287fb0892491790b316e2b93e232
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NTN4 CLDN4 CLDN19 AGRN

1.22e-041995742e7f517c0444b4f29ff11c26ab32e9cc0f7e99ef
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NTN4 CLDN4 CLDN19 AGRN

1.24e-04200574ae91dc047dc80560ba298d8d21a772154fa2775d
ComputationalNeighborhood of RING1

KRT31 KRT32 KRT35 ODF1

1.89e-04112284GCM_RING1
ComputationalNeighborhood of LTK

KRT32 KRT35 ODF1

2.23e-0446283GCM_LTK
ComputationalNeighborhood of HMGA2

KRT31 KRT32 KRT35 ODF1

2.70e-04123284GCM_HMGA2
Drugnaphthol-AS-acetate

MPO VWF CHRDL1 EPX

5.43e-0816554CID000096045
Drug2,6-dichloroquinone

MPO CHRDL1 EPX

2.17e-0611553CID000012771
Drug2-bromohexadecanal

MPO EPX

5.73e-062552CID015701742
DrugMLD987

MPO EPX

5.73e-062552CID006918516
Drugbromine trichloride

MPO EPX

5.73e-062552CID003014687
DrugAC1L22VU

MPO EPX

5.73e-062552CID000040008
Drugcarbonate radical

MPO IGFLR1 EPX

5.95e-0615553CID005460603
Drugnaphthol AS-D acetate

MPO CHRDL1 EPX

7.31e-0616553CID003562787
DrugHOBr

MPO KRT31 EPX

1.26e-0519553CID000083547
DrugAC1L1I0J

KRT31 KRT32 KRT35

1.26e-0519553CID000004371
Drug4-chloro-1,2-benzoquinone

MPO EPX

1.72e-053552CID000093145
DrugAC1L2HYK

MPO EPX

1.72e-053552CID000021263
DrugNorakin

KRT31 KRT32

1.72e-053552CID000161077
Drugyellow prussiate

MPO ZFPM1 EPX

1.72e-0521553CID000161067
Drugperacetic acid

MPO ZFPM1 EPX

3.33e-0526553CID000006585
Drugi0830

MPO EPX

3.43e-054552CID000151254
DrugAC1L2O1K

MPO EPX

3.43e-054552CID000125126
Drug4-nitroestradiol

MPO EPX

3.43e-054552CID000233494
Drugdesethylaprindine

KRT31 KRT32

3.43e-054552CID000162697
DrugBHAC

MPO RERE EPX

3.74e-0527553CID000003228
Drugtyrosine

MPO CHRDL1 EPX

4.66e-0529553CID005460802
DrugCI-949

MPO EPX

5.70e-055552CID000159562
DrugPummerer's ketone

MPO EPX

5.70e-055552CID000099055
Drugtartryl diazide

KRT31 KRT32

5.70e-055552CID000193925
DrugAC1MOE91

MPO EPX

5.70e-055552CID003342294
Drug4-biphenylboronic acid

MPO EPX

5.70e-055552CID000151253
DrugZ-103

CHRDL1 RERE

5.70e-055552CID006918055
Drugt383

MPO EPX

5.70e-055552CID000074847
Drugisotrityrosine

MPO EPX

5.70e-055552CID000196044
DrugAC1Q6QQG

MPO EPX

5.70e-055552CID000124376
Drug2-chloro-1,4-dimethoxybenzene

MPO EPX

5.70e-055552CID000246724
Drug5-hydroxypropafenone

KRT31 KRT32 NDP

7.57e-0534553CID000107927
Drugnitrite

MPO CHRDL1 RERE EPX AGRN

8.19e-05184555CID000024529
Drugindamine

MPO EPX

8.54e-056552CID000010841
Drugbromamine

MPO EPX

8.54e-056552CID000123346
Drugpodocarpic acid

KRT31 KRT32

8.54e-056552CID000093017
Drugammonium tartrate

MPO EPX

8.54e-056552CID000018352
Drugdiffractaic acid

MPO RERE

8.54e-056552CID000094870
Drug5-hydroxyconiferyl alcohol

MPO EPX

8.54e-056552CID005282095
Drug3',4'-dehydrovinblastine

MPO EPX

8.54e-056552CID000151120
DrugPPHP

MPO EPX

8.54e-056552CID006438577
Drug5-dehydrosparteine

KRT31 KRT32

8.54e-056552CID000160614
Drug4-methoxymandelic acid

MPO EPX

8.54e-056552CID000112056
DrugPmx-53

MPO EPX

8.54e-056552CID006918468
Drugpulcherosine

MPO EPX

8.54e-056552CID000124402
DrugVistar

KRT31 KRT32 KRT35

9.00e-0536553CID000040896
DrugPropofol [2078-54-8]; Up 200; 22.4uM; HL60; HT_HG-U133A

ARMC9 RERE ARHGAP35 EPX GP5

1.13e-041975553048_UP
DrugLincomycin hydrochloride [859-18-7]; Up 200; 9uM; HL60; HT_HG-U133A

TRAF4 RERE ARHGAP35 EPX TLR8

1.13e-041975552380_UP
Drug3-(3,4-dimethoxyphenyl) acrylate

MPO EPX

1.19e-047552CID000016848
Drugbenzidinediimine

MPO EPX

1.19e-047552CID000115267
DrugN-(carboxyheptyl)maleimide

MPO EPX

1.19e-047552CID000092656
DrugNSC 46286

CHRDL1 RERE

1.19e-047552CID000006881
Drugasarol methyl ether

MPO EPX

1.19e-047552CID000097686
DrugPreView

CHRDL1 ZFPM1 DLL1

1.33e-0441553CID000176144
Drugresorcinol

MPO VWF EPX

1.43e-0442553CID000005054
Drugnitrate

MPO CHRDL1 ZFPM1 RERE EPX DLL1

1.44e-04331556CID000000943
DrugAC1L3RVN

MPO EPX

1.59e-048552CID000094274
DrugCI-959

MPO EPX

1.59e-048552CID000159289
DrugPH 163

MPO EPX

1.59e-048552ctd:C104857
DrugRbBr

MPO EPX

1.59e-048552CID004670918
Drugnitrogen dioxide

MPO ZFPM1 EPX

1.65e-0444553CID000025352
Drug3H-diazirine

KRT31 KRT32 CHRNA4

1.76e-0445553CID000078958
Drug9-(5',5'-difluoro-5'-phosphonopentyl)guanine

KRT31 KRT32 KRT35

1.88e-0446553CID000448999
Drugdeuterohemin

MPO EPX

2.04e-049552CID003082177
DrugN-NBD-PE

KRT31 KRT32

2.04e-049552CID000127398
DrugAC1O5E2B

MPO EPX

2.04e-049552CID002724224
DrugReactive Black 5

MPO EPX

2.04e-049552CID005360531
Drugisothiocyanato thiocyanate

MPO EPX

2.04e-049552CID000521282
DrugAC1L9785

MPO CHRDL1 EPX

2.27e-0449553CID000439374
DrugNVP ABE171

MPO EPX

2.55e-0410552ctd:C451724
Drugphosphatidylinositol 3,4,5-triphosphate

VWF GP5

2.55e-0410552ctd:C060974
Drug1,4-dimethoxybenzene

MPO EPX

2.55e-0410552CID000009016
Drugtrityrosine

MPO EPX

2.55e-0410552CID000164782
Drug3-dimethylaminobenzoic acid

MPO EPX

2.55e-0410552CID000066837
Drugovothiol

MPO EPX

2.55e-0410552CID000129029
Drugnaphthol AS-MX

MPO EPX

2.55e-0410552CID000066717
DrugNSC34533

KRT31 KRT32 KRT35

3.03e-0454553CID000003512
DrugAC1NUTGS

MPO EPX

3.11e-0411552CID005460627
Drugnew fuchsin

MPO EPX

3.11e-0411552CID000018611
DrugNarea

MPO CHRDL1

3.11e-0411552CID000016556
DrugS-hexylglutathione

MPO EPX DPPA3

3.20e-0455553CID000005140
DrugAC1Q5QKQ

MPO EPX

3.72e-0412552CID000134162
DrugHA22

KRT31 KRT32

3.72e-0412552CID003035755
Druganisyl alcohol

MPO EPX

3.72e-0412552CID000007738
DrugAC1NUW7G

MPO CHRDL1 EPX

4.35e-0461553CID005462208
Drugphycoerythrobilin

CHRDL1 CLDN4

4.39e-0413552CID005289130
DrugAC1L38JC

MPO EPX

4.39e-0413552CID000084962
Drugkappa-casein glycomacropeptide

MPO MUC4

4.39e-0413552ctd:C020251
Drugo-tyrosine

MPO EPX

4.39e-0413552CID000091482
Drugfluorescein isothiocyanate

MPO VWF ODF1 EPX

4.41e-04147554CID000018730
DrugHMS3267E16

MPO KRT31 EPX

4.56e-0462553CID000003668
Drugprotoporphyrin

MPO KRT32 CHRDL1 EPX

4.87e-04151554CID000004971
DrugSudan black B

MPO CHRDL1 EPX

5.01e-0464553CID000061336
Drug3-methyl-2-benzothiazolinone hydrazone

MPO EPX

5.12e-0414552CID000014319
Drugveratraldehyde

MPO EPX

5.12e-0414552CID000008419
DrugAC1MM84E

RERE AGRN DPPA3

5.48e-0466553CID003256856
Drugacetylhydrazine

MPO ODF1 DLL1

5.48e-0466553ctd:C014949
DrugAC1O3H1D

KRT31 KRT35 EPX

5.73e-0467553CID006328166
Drugaminostimil

MPO EPX

5.90e-0415552CID000021450
Drugdiacetyldeuteroheme

MPO EPX

5.90e-0415552CID004629150
Diseasebasophil count

MPO TRIM49C TRIM49D1 ZFPM1 RERE EPX

2.48e-04483546EFO_0005090
Diseasefemoral neck bone mineral density

PDXDC1 ARMC12 ZFPM1 RERE

4.61e-04196544EFO_0007785
Diseasemyeloperoxidase (MPO)-DNA complex measurement

MPO EPX

7.42e-0422542EFO_0011039
Diseasepancreatic cancer (is_implicated_in)

MPO CLDN4 MUC4

1.15e-03112543DOID:1793 (is_implicated_in)
DiseasePapillary Renal Cell Carcinoma

PDXDC1 KRT32 MUC4

1.68e-03128543C1306837
DiseaseRenal Cell Carcinoma

PDXDC1 KRT32 MUC4

1.68e-03128543C0007134
DiseaseSarcomatoid Renal Cell Carcinoma

PDXDC1 KRT32 MUC4

1.68e-03128543C1266043
DiseaseChromophobe Renal Cell Carcinoma

PDXDC1 KRT32 MUC4

1.68e-03128543C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

PDXDC1 KRT32 MUC4

1.68e-03128543C1266044
DiseaseCardiovascular Diseases

MPO VWF

1.99e-0336542C0007222
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

PDXDC1 KRT32 MUC4

2.54e-03148543C0279702
Diseaseend stage renal disease (is_implicated_in)

MPO VWF

2.58e-0341542DOID:783 (is_implicated_in)
Diseaseprimary immunodeficiency disease (is_implicated_in)

ZNFX1 TLR8

2.70e-0342542DOID:612 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
ARPREGSCPSKCSCP

LINC00114

76

Q6XXX2
PSPCKCTCKKEPSSV

CHRNA4

526

P43681
CNPKSCLQPSRECLP

ANTXRL

571

A6NF34
LECKNSPIARTPPCC

EIF4EBP3

46

O60516
VCKKSPCPSVVAPVC

AGRN

196

O00468
FLCCTCPEPERPNSS

CLDN19

181

Q8N6F1
RPFPGTVTKSECCCA

FBN3

631

Q75N90
CKPPLCSNSPICIAR

ARMC12

41

Q5T9G4
RFPCPVSLDAKCQPC

IQCN

246

Q9H0B3
VTRCCPCNVCSPPKA

SLC34A3

566

Q8N130
CQPMCTCPPAFTDSR

MUC4

5141

Q99102
PCATTNACSKPIGPC

KRT31

371

Q15323
PFCAACQPLRLPACS

KMT5C

296

Q86Y97
CASAFTCKPRAPCTP

ARMC9

756

Q7Z3E5
KLPCNPCSTPSCTTC

KRT32

406

Q14532
CIPFFRSAPSCPQNK

EPX

281

P11678
CETSCVQQPPCFPLK

MPO

281

P05164
LPFPCLCRVPCNTVF

PDXDC1

196

Q6P996
LPFPCLCRVPCNTMF

PDXDC2P

196

Q6P474
VCPFPQCRKSCPSAS

ZFPM1

291

Q8IX07
AARTNCSPRPICVPC

KRT35

436

Q92764
TPPVCCPHCSKQYSS

PRDM10

831

Q9NQV6
VKIESPCYPCTSPCS

ODF1

196

Q14990
CCESCSKRSSTLPPP

ADAMTS3

1046

O15072
KLTCAFPVSVPDSCC

CHRDL1

161

Q9BU40
PPPCACRTFFRVCLK

DLL1

51

O00548
NKCCSSCLQRFGPPP

IGFLR1

36

Q9H665
CCPPCPSRIAAKLAF

ABHD17C

21

Q6PCB6
AQPFPCPPACKCVFR

GP5

16

P40197
VPVCNKPVCFVPTCS

KRTAP10-10

106

P60014
SAQCLPPASSCCAPR

LCE3B

26

Q5TA77
SSSCGPQCRQPSCPV

KRTAP16-1

51

A8MUX0
PQCRQPSCPVSSCAQ

KRTAP16-1

56

A8MUX0
SSPCQPTCYVVKRCP

KRTAP16-1

326

A8MUX0
CPSVPSHKFCFPCSR

IRF2BP2

521

Q7Z5L9
SRPFKCPCSFCVSNG

DPPA3

126

Q6W0C5
TKCPPCSNVLCNPSE

DYRK3

41

O43781
NCSFSPPLRPIFCCI

TRIM49

436

P0CI25
CPPSCLDPKANRSCS

SSPOP

2636

A2VEC9
FSAPDACKPCSCHPV

NTN4

386

Q9HB63
SQACCRSPTPALCDP

RERE

136

Q9P2R6
VYHPTKETCPSCPAC

ARHGAP35

551

Q9NRY4
SPVCSCESASPCPKQ

SLX4IP

271

Q5VYV7
LCCNCPPRTDKPYSA

CLDN4

181

O14493
NCPRCFNAPFPCVPC

TLR8

256

Q9NR97
TPPLPSYCSTNVCRC

STIL

591

Q15468
PPAGPCKRCRSFCAA

TTLL8

816

A6PVC2
KTPCPSPSTHFCRVC

ZDHHC22

86

Q8N966
CTTQPCPTAKAPTCG

VWF

2291

P04275
NCSFSPPLRPIFCCS

TRIM51

436

Q9BSJ1
NCSFSPPLRPIFCCI

TRIM49C

436

P0CI26
PSTRFTCPHCAKVCK

ZBTB4

761

Q9P1Z0
CSFNVIPCPNRCPMK

TRAF4

106

Q9BUZ4
KQPFRSSCHCCRPQT

NDP

86

Q00604
YQCTKLCSEPCNRPP

ZNFX1

1521

Q9P2E3
NCSFSPPLRPIFCCV

TRIM49D1

436

C9J1S8
SPEATLCPQKTCPCD

ZNF792

121

Q3KQV3
NCSFSPPLRPIFCCI

TRIM49B

436

A6NDI0
ESCACPASCKSPRPS

ZAN

1051

Q9Y493