Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	endopeptidase activity	ZMPSTE24 ERAP1 REN CAPN13 PLAU MMP10 TMPRSS7 CTSD USP48 CTSV CTSO	8.47e-06	430	98	11	GO:0004175
GeneOntologyMolecularFunction	peptidase activity	ZMPSTE24 ERAP1 PARK7 REN CAPN13 PLAU MMP10 TMPRSS7 CTSD USP48 CTSV CTSO USP47	1.85e-05	654	98	13	GO:0008233
GeneOntologyMolecularFunction	cysteine-type endopeptidase activity	CAPN13 CTSD USP48 CTSV CTSO	6.53e-05	86	98	5	GO:0004197
GeneOntologyMolecularFunction	collagen fibril binding	AMBP TNXB	7.13e-05	3	98	2	GO:0098633
GeneOntologyMolecularFunction	cysteine-type peptidase activity	CAPN13 CTSD USP48 CTSV CTSO USP47	3.70e-04	192	98	6	GO:0008234
GeneOntologyCellularComponent	blood microparticle	AMBP CP ITIH2 FGA C8A C9	8.39e-05	144	104	6	GO:0072562
Domain	CUB	CSMD3 NRP1 ATRNL1 TMPRSS7	1.21e-04	49	97	4	PF00431
Domain	CUB	CSMD3 NRP1 ATRNL1 TMPRSS7	1.31e-04	50	97	4	SM00042
Domain	-	CSMD3 NRP1 ATRNL1 TMPRSS7	1.53e-04	52	97	4	2.60.120.290
Domain	CUB	CSMD3 NRP1 ATRNL1 TMPRSS7	1.65e-04	53	97	4	PS01180
Domain	CUB_dom	CSMD3 NRP1 ATRNL1 TMPRSS7	2.19e-04	57	97	4	IPR000859
Domain	THIOL_PROTEASE_CYS	CAPN13 CTSV CTSO	3.24e-04	26	97	3	PS00139
Domain	THIOL_PROTEASE_ASN	CAPN13 CTSV CTSO	3.63e-04	27	97	3	PS00640
Domain	THIOL_PROTEASE_HIS	CAPN13 CTSV CTSO	3.63e-04	27	97	3	PS00639
Domain	MACPF_CS	C8A C9	3.95e-04	6	97	2	IPR020863
Domain	MACPF_2	C8A C9	5.51e-04	7	97	2	PS51412
Domain	MACPF_1	C8A C9	5.51e-04	7	97	2	PS00279
Domain	Aspartic_peptidase_N	REN CTSD	5.51e-04	7	97	2	IPR012848
Domain	A1_Propeptide	REN CTSD	5.51e-04	7	97	2	PF07966
Domain	RRM	PUF60 MATR3 PABPC5 RAVER2 ZNF638 SPEN	9.42e-04	217	97	6	SM00360
Domain	LDLR_class-A_CS	C8A C9 TMPRSS7	1.17e-03	40	97	3	IPR023415
Domain	Aspartic_peptidase_A1	REN CTSD	1.17e-03	10	97	2	IPR001461
Domain	L27_C	MPP3 MPP4	1.17e-03	10	97	2	IPR014775
Domain	MAC_perforin	C8A C9	1.17e-03	10	97	2	IPR001862
Domain	L27	MPP3 MPP4	1.17e-03	10	97	2	PF02828
Domain	PEPTIDASE_A1	REN CTSD	1.17e-03	10	97	2	IPR033121
Domain	Asp	REN CTSD	1.17e-03	10	97	2	PF00026
Domain	PEPTIDASE_A1	REN CTSD	1.17e-03	10	97	2	PS51767
Domain	RRM_dom	PUF60 MATR3 PABPC5 RAVER2 ZNF638 SPEN	1.19e-03	227	97	6	IPR000504
Domain	RRM	PUF60 MATR3 PABPC5 RAVER2 ZNF638 SPEN	1.27e-03	230	97	6	PS50102
Domain	EGF_3	FAT1 ATRNL1 PLAU C8A C9 TNXB	1.42e-03	235	97	6	PS50026
Domain	Pept_his_AS	CTSV CTSO	1.42e-03	11	97	2	IPR025660
Domain	DUF1220	NBPF9 NBPF14	1.42e-03	11	97	2	PF06758
Domain	MACPF	C8A C9	1.42e-03	11	97	2	PF01823
Domain	NBPF_dom	NBPF9 NBPF14	1.42e-03	11	97	2	IPR010630
Domain	NBPF	NBPF9 NBPF14	1.42e-03	11	97	2	PS51316
Domain	Ldl_recept_a	C8A C9 TMPRSS7	1.65e-03	45	97	3	PF00057
Domain	-	REN CTSD	1.70e-03	12	97	2	2.40.70.10
Domain	MACPF	C8A C9	1.70e-03	12	97	2	IPR020864
Domain	MACPF	C8A C9	1.70e-03	12	97	2	SM00457
Domain	Znf_C2H2_matrin	MATR3 ZNF638	1.70e-03	12	97	2	IPR000690
Domain	ASP_PROTEASE	REN CTSD	1.70e-03	12	97	2	PS00141
Domain	-	PUF60 MATR3 PABPC5 RAVER2 ZNF638 SPEN	1.72e-03	244	97	6	3.30.70.330
Domain	-	C8A C9 TMPRSS7	1.75e-03	46	97	3	4.10.400.10
Domain	EGF-like_dom	FAT1 ATRNL1 PLAU C8A C9 TNXB	1.90e-03	249	97	6	IPR000742
Domain	LDLRA_1	C8A C9 TMPRSS7	1.98e-03	48	97	3	PS01209
Domain	Kelch_2	KLHL36 ATRNL1	2.01e-03	13	97	2	IPR011498
Domain	L27	MPP3 MPP4	2.01e-03	13	97	2	SM00569
Domain	L27	MPP3 MPP4	2.01e-03	13	97	2	PS51022
Domain	L27_dom	MPP3 MPP4	2.01e-03	13	97	2	IPR004172
Domain	Kelch_2	KLHL36 ATRNL1	2.01e-03	13	97	2	PF07646
Domain	Pept_C1	CTSV CTSO	2.01e-03	13	97	2	SM00645
Domain	Peptidase_C1A_C	CTSV CTSO	2.01e-03	13	97	2	IPR000668
Domain	Peptidase_C1	CTSV CTSO	2.01e-03	13	97	2	PF00112
Domain	Aspartic_peptidase_AS	REN CTSD	2.01e-03	13	97	2	IPR001969
Domain	Peptidase_C1A	CTSV CTSO	2.01e-03	13	97	2	IPR013128
Domain	LDrepeatLR_classA_rpt	C8A C9 TMPRSS7	2.10e-03	49	97	3	IPR002172
Domain	LDLa	C8A C9 TMPRSS7	2.10e-03	49	97	3	SM00192
Domain	LDLRA_2	C8A C9 TMPRSS7	2.10e-03	49	97	3	PS50068
Domain	EGF_1	FAT1 ATRNL1 PLAU C8A C9 TNXB	2.14e-03	255	97	6	PS00022
Domain	Nucleotide-bd_a/b_plait	PUF60 MATR3 PABPC5 RAVER2 ZNF638 SPEN	2.27e-03	258	97	6	IPR012677
Domain	EGF-like_CS	FAT1 ATRNL1 PLAU C8A C9 TNXB	2.41e-03	261	97	6	IPR013032
Domain	EGF_2	FAT1 ATRNL1 PLAU C8A C9 TNXB	2.59e-03	265	97	6	PS01186
Domain	Guanylate_kinase_CS	MPP3 MPP4	3.06e-03	16	97	2	IPR020590
Domain	MAM_1	NRP1 MAMDC2	3.06e-03	16	97	2	PS00740
Domain	FKBP_PPIASE	FKBP9 FKBP14	3.06e-03	16	97	2	PS50059
Domain	FKBP_C	FKBP9 FKBP14	3.06e-03	16	97	2	PF00254
Domain	MAM	NRP1 MAMDC2	3.45e-03	17	97	2	SM00137
Domain	PPIase_FKBP	FKBP9 FKBP14	3.45e-03	17	97	2	IPR023566
Domain	Peptidase_aspartic_dom	REN CTSD	3.45e-03	17	97	2	IPR021109
Domain	MAM	NRP1 MAMDC2	3.87e-03	18	97	2	PF00629
Domain	MAM_dom	NRP1 MAMDC2	3.87e-03	18	97	2	IPR000998
Domain	ZF_MATRIN	MATR3 ZNF638	3.87e-03	18	97	2	PS50171
Domain	MAM_2	NRP1 MAMDC2	3.87e-03	18	97	2	PS50060
Domain	Fibrinogen_CS	FGA TNXB	4.31e-03	19	97	2	IPR020837
Domain	RRM_1	PUF60 PABPC5 RAVER2 ZNF638 SPEN	4.60e-03	208	97	5	PF00076
Domain	PPIase_FKBP_dom	FKBP9 FKBP14	4.77e-03	20	97	2	IPR001179
Pubmed	A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.	NBPF8 NBPF20 NBPF19 NBPF9 NBPF10 NBPF14	3.43e-11	21	105	6	16079250
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	AMBP ZMPSTE24 RARS1 PARK7 ANXA11 CP NEB CEMIP2 FAT1 ATP6V1D FGA C9 RAB21 CTSD SPEN	4.17e-07	1016	105	15	19056867
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	SEL1L ZMPSTE24 ERAP1 FKBP9 NBPF26 GDE1 CEMIP2 NRP1 FAT1 P4HA1 RAB21 CTSD USP48 SUCO PLS3 FKBP14	6.46e-07	1201	105	16	35696571
Pubmed	The human plasma proteome: a nonredundant list developed by combination of four separate sources.	AMBP PARK7 CP ITIH2 FGA CTSD GOLGA4	7.33e-07	165	105	7	14718574
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	NBPF8 FAT1 NBPF9 SBF2 NBPF10 FGA NBPF14	8.96e-07	170	105	7	23314748
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	CP ITIH2 NRP1 FGA C8A C9 CTSD TNXB	1.20e-06	257	105	8	16335952
Pubmed	Evolutionary history and genome organization of DUF1220 protein domains.	NBPF8 NBPF9 NBPF14	3.16e-06	10	105	3	22973535
Pubmed	Developmentally regulated transcription of the four liver-specific genes for inter-alpha-inhibitor family in mouse.	AMBP ITIH2 TYR	4.33e-06	11	105	3	7504460
Pubmed	Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.	AMBP CP ITIH2 FGA C8A C9	5.01e-06	143	105	6	22516433
Pubmed	Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.	AMBP ANXA11 ITIH2 FGA CTSD TNXB	7.38e-06	153	105	6	25037231
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	RARS1 PUF60 FKBP9 VPS26A TWF1 EIF2S1 ASNS NUP133 RPUSD2 NCOA7 UBE3C USP48 GNL1 PLS3 USP47 WDR44	7.57e-06	1455	105	16	22863883
Pubmed	Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin.	AMBP ITIH2	9.03e-06	2	105	2	7682553
Pubmed	Binding of human complement C8 to C9: role of the N-terminal modules in the C8 alpha subunit.	C8A C9	9.03e-06	2	105	2	12463754
Pubmed	Mapping of human DNA-binding nuclear protein (NP220) to chromosome band 2p13.1-p13.2 and its relation to matrin 3.	MATR3 ZNF638	9.03e-06	2	105	2	9757574
Pubmed	Plasma cathepsin D isoforms and their active metabolites increase after myocardial infarction and contribute to plasma renin activity.	REN CTSD	9.03e-06	2	105	2	15739123
Pubmed	Analysis of the specific association of the eighth and ninth components of human complement: identification of a direct role for the alpha subunit of C8.	C8A C9	9.03e-06	2	105	2	4063341
Pubmed	Anti-Aggregative Effect of the Antioxidant DJ-1 on the TPPP/p25-Derived Pathological Associations of Alpha-Synuclein.	PARK7 TPPP	9.03e-06	2	105	2	34831132
Pubmed	Novel genes and mutations in patients affected by recurrent pregnancy loss.	FGA MMP10	9.03e-06	2	105	2	29016666
Pubmed	Cross-Linking Mass Spectrometry Uncovers Interactions Between High-Density Lipoproteins and the SARS-CoV-2 Spike Glycoprotein.	AMBP CP ITIH2 FGA C8A	9.10e-06	92	105	5	37343697
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	AMBP PARK7 ANXA11 CP ITIH2 CPNE6 FGA PLAU C8A C9 RAB21 CTSD TNXB	2.10e-05	1070	105	13	23533145
Pubmed	The Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour.	ATP6V1D NCOA7 CTSD	2.11e-05	18	105	3	33340069
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	TRIM46 RAP1GAP RARS1 PARK7 MATR3 NBPF26 TARS2 CDK13 ZNF638 CTSD SUCO FBXO21	2.36e-05	925	105	12	28986522
Pubmed	Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion.	SBF2 RAB21	2.70e-05	3	105	2	25648148
Pubmed	Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor.	AMBP ITIH2	2.70e-05	3	105	2	7513643
Pubmed	Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9.	C8A C9	2.70e-05	3	105	2	21507937
Pubmed	Genetic down-regulation of phosphoinositide 3-kinase by bikunin correlates with suppression of invasion and metastasis in human ovarian cancer HRA cells.	AMBP PLAU	2.70e-05	3	105	2	14597629
Pubmed	The Compact and Biologically Relevant Structure of Inter-α-inhibitor Is Maintained by the Chondroitin Sulfate Chain and Divalent Cations.	AMBP ITIH2	2.70e-05	3	105	2	26728454
Pubmed	Cathepsins D and L reduce the toxicity of advanced glycation end products.	CTSD CTSV	2.70e-05	3	105	2	22245096
Pubmed	cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins.	AMBP ITIH2	2.70e-05	3	105	2	3663330
Pubmed	Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice.	CTSD CTSV	2.70e-05	3	105	2	12676526
Pubmed	Gene expression analysis of the embryonic subplate.	CSMD3 NRP1 SLC8A2 KCNT2 CTSD PLS3	3.00e-05	196	105	6	21862448
Pubmed	Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes.	AMBP ITIH2	5.40e-05	4	105	2	2465147
Pubmed	The TSG-6/HC2-mediated transfer is a dynamic process shuffling heavy chains between glycosaminoglycans.	AMBP ITIH2	5.40e-05	4	105	2	20463016
Pubmed	Identification of pathogenic T cell epitopes near cathepsin cleavage sites in thyroglobulin.	CTSD CTSV	5.40e-05	4	105	2	23315080
Pubmed	Protease cleavage sites in HIV-1 gp120 recognized by antigen processing enzymes are conserved and located at receptor binding sites.	CTSD CTSV	5.40e-05	4	105	2	19939935
Pubmed	Evidence that C5b recognizes and mediates C8 incorporation into the cytolytic complex of complement.	C8A C9	5.40e-05	4	105	2	3624872
Pubmed	Expression of cathepsin proteinases by mouse trophoblast in vivo and in vitro.	CTSD CTSV	5.40e-05	4	105	2	10633857
Pubmed	Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease).	CTSD CTSV	5.40e-05	4	105	2	16314482
Pubmed	[The lysosomal cathepsins B, L and D in development of murine experimental leukemias].	CTSD CTSV	5.40e-05	4	105	2	20017393
Pubmed	Common genetic variants associated with plasma fibrin D-dimer concentration in older European- and African-American adults.	FGA PLAU	5.40e-05	4	105	2	18208536
Pubmed	Cathepsin L is required for endothelial progenitor cell-induced neovascularization.	CTSD CTSV	5.40e-05	4	105	2	15665831
Pubmed	Cathepsin B and D deficiency in the mouse pancreas induces impaired autophagy and chronic pancreatitis.	CTSD CTSV	5.40e-05	4	105	2	33758261
Pubmed	RARγ promotes the invasion and metastasis of thyroid carcinoma by activating the JAK1-STAT3-CD24/MMPs axis.	RARG JAK1	5.40e-05	4	105	2	37897947
Pubmed	Functional studies of the MACPF domain of human complement protein C8alpha reveal sites for simultaneous binding of C8beta, C8gamma, and C9.	C8A C9	5.40e-05	4	105	2	16618117
Pubmed	Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.	AMBP ITIH2 FGA CTSD TNXB	5.79e-05	135	105	5	28675934
Pubmed	Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.	SEL1L FKBP9 ITIH2 CTSD	6.52e-05	71	105	4	12754519
Pubmed	Little skate genome provides insights into genetic programs essential for limb-based locomotion.	ETV5 KLHL36 ATP6V1D	7.42e-05	27	105	3	36288084
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	RARS1 PCNX3 PUF60 PARK7 CP P4HA1 A2ML1 FGA ZNF638 PLS3	7.67e-05	732	105	10	34732716
Pubmed	Proteome-wide characterization of N-glycosylation events by diagonal chromatography.	CP ITIH2 A2ML1 C9	8.96e-05	77	105	4	16944957
Pubmed	Sequence and chromosomal localization of mouse annexin XI.	ANXA11 PLAU	8.97e-05	5	105	2	8938449
Pubmed	TSG-6 potentiates the antitissue kallikrein activity of inter-alpha-inhibitor through bikunin release.	AMBP ITIH2	8.97e-05	5	105	2	16873769
Pubmed	The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues.	C8A C9	8.97e-05	5	105	2	10551839
Pubmed	Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily.	AMBP ITIH2	8.97e-05	5	105	2	1385302
Pubmed	Role of Myeloperoxidase Oxidants in the Modulation of Cellular Lysosomal Enzyme Function: A Contributing Factor to Macrophage Dysfunction in Atherosclerosis?	CTSD CTSV	8.97e-05	5	105	2	27997605
Pubmed	Regulated renin release from 3T3-L1 adipocytes.	REN CTSD	8.97e-05	5	105	2	19293336
Pubmed	A molecular network for the transport of the TI-VAMP/VAMP7 vesicles from cell center to periphery.	RAB21 GOLGA4	8.97e-05	5	105	2	22705394
Pubmed	The genes for the inter-alpha-inhibitor family share a homologous organization in human and mouse.	AMBP ITIH2	8.97e-05	5	105	2	1371941
Pubmed	SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.	RARS1 PUF60 ANXA11 TARS2 ASNS NUP133 FGA RAB21 CTSD	9.63e-05	607	105	9	39147351
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	RARS1 PUF60 PARK7 MATR3 FN3KRP TARS2 EIF2S1 ASNS NUP133 UBE3C CTSD SPEN PLS3 GOLGA4	9.93e-05	1425	105	14	30948266
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	RARS1 ANXA11 EIF2S1 ASNS NUP133 RAB21 CTSD PLS3	1.14e-04	484	105	8	31995728
Pubmed	Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study.	FGA C8A C9	1.24e-04	32	105	3	18842294
Pubmed	Characterization of molecules binding to the 70K N-terminal region of fibronectin by IFAST purification coupled with mass spectrometry.	ITIH2 FGA C9	1.24e-04	32	105	3	23750785
Pubmed	Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis.	ERAP1 PARK7 MATR3 P4HA1 CTSD	1.25e-04	159	105	5	31332168
Pubmed	Interferons induce tyrosine phosphorylation of the eIF2alpha kinase PKR through activation of Jak1 and Tyk2.	JAK1 EIF2S1	1.34e-04	6	105	2	17290288
Pubmed	Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9.	C8A C9	1.34e-04	6	105	2	22832194
Pubmed	Biogenesis and proteolytic processing of lysosomal DNase II.	CTSD CTSV	1.34e-04	6	105	2	23516607
Pubmed	Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family.	FKBP9 FKBP14	1.34e-04	6	105	2	12036304
Pubmed	Human colostrum: identification of minor proteins in the aqueous phase by proteomics.	AMBP ERAP1 CP NRP1 CTSD	1.37e-04	162	105	5	16502470
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	SEL1L RAP1GAP ERAP1 PARK7 REN TARS2 NEB TLR10 FAT1 ZNF638 USP48 TNXB PLS3	1.43e-04	1293	105	13	15342556
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	SEL1L ZMPSTE24 RARS1 ERAP1 PARK7 FKBP9 JAK1 FAT1 P4HA1 UBE3C RAB21 CTSD PLS3	1.47e-04	1297	105	13	33545068
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	RARS1 ERAP1 PARK7 PABPC5 TARS2 ITIH2 UBE3C CTSD FBXO21	1.55e-04	647	105	9	26618866
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	NBPF8 MATR3 NEB CSMD3 ZNF462 NBPF9 NBPF10 NBPF14	1.69e-04	513	105	8	25798074
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	SEL1L MPP3 MATR3 FN3KRP VPS26A ASNS NUP133 UBE3C FBXO21 PLS3 USP47	1.78e-04	974	105	11	28675297
Pubmed	A role for cathepsin E in the processing of mast-cell carboxypeptidase A.	CTSD CTSV	1.88e-04	7	105	2	15860733
Pubmed	CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers.	C8A C9	1.88e-04	7	105	2	30552328
Pubmed	Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina.	TYR GUCY2F	1.88e-04	7	105	2	8838319
Pubmed	Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice.	CTSD CTSV	1.88e-04	7	105	2	12775715
Pubmed	Cathespin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis.	CTSD CTSV	1.88e-04	7	105	2	17500053
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	ANXA11 FGA CTSD CTSV TNXB	1.96e-04	175	105	5	28071719
Pubmed	Identification and applications of repetitive probes for gene mapping in the mouse.	REN TYR PLAU	2.09e-04	38	105	3	1673105
Pubmed	Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.	TWF1 JAK1 FAT1 P4HA1 CDK13 EIF2S1 CTSD	2.22e-04	401	105	7	25852190
Pubmed	Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.	TWF1 NRP1 JAK1 FAT1 PLAU RAB21	2.34e-04	285	105	6	21423176
Pubmed	Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis.	RARS1 MATR3 P4HA1 EIF2S1	2.37e-04	99	105	4	27746211
Pubmed	A pharmacogenetic study of polymorphisms in interferon pathway genes and response to interferon-alpha treatment in chronic hepatitis B patients.	JAK1 EIF2S1	2.50e-04	8	105	2	19559055
Pubmed	A genetic map of mouse chromosome 1 near the Lsh-Ity-Bcg disease resistance locus.	REN NEB	2.50e-04	8	105	2	1970800
Pubmed	Lysosomal processing of progranulin.	CTSD CTSV	2.50e-04	8	105	2	28835281
Pubmed	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	ANXA11 AS3MT ITIH2 NRP1 P4HA1 ATRNL1 PLAU	2.73e-04	415	105	7	16385451
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	RARS1 PUF60 PARK7 MATR3 FN3KRP CDK13 EIF2S1 ZNF638 CTSD GNL1 CTSV PLS3 GOLGA4	3.42e-04	1415	105	13	28515276
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	ZMPSTE24 KIAA0232 VPS26A TARS2 CEMIP2 JAK1 FAT1 FGA PLAU UBE3C RAB21	3.69e-04	1061	105	11	33845483
Pubmed	Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches.	PARK7 ANXA11 CP JAK1 UBE3C	3.79e-04	202	105	5	29540532
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	TRIM46 RAP1GAP PARK7 MATR3 FKBP9 TPPP TWF1 SLC8A2 CPNE6 EIF2S1 ATP6V1D FGA PLS3	3.81e-04	1431	105	13	37142655
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	RHOBTB3 NRP1 JAK1 ZNF638 UBE3C SPEN	3.86e-04	313	105	6	38270169
Pubmed	Expression and localization of Inter-alpha Inhibitors in rodent brain.	AMBP ITIH2	4.00e-04	10	105	2	26964679
Pubmed	Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations.	CTSD CTSV	4.00e-04	10	105	2	20541250
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	RARS1 PUF60 MATR3 ITIH2 TWF1 EIF2S1 NUP133 ZNF638 C9 CTSD SPEN PLS3	4.17e-04	1257	105	12	36526897
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	RARS1 JAK1 NUP133 UBE3C USP47	4.73e-04	212	105	5	33853758
Pubmed	Cathepsin D in pancreatic acinar cells is implicated in cathepsin B and L degradation, but not in autophagic activity.	CTSD CTSV	4.88e-04	11	105	2	26682926
Pubmed	Charcot-Marie-Tooth Neuropathy Type 4 – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	SH3TC2 SBF2	4.88e-04	11	105	2	20301641
Pubmed	Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study.	JAK1 EIF2S1	4.88e-04	11	105	2	12447867
Pubmed	A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo.	FGA PLAU	4.88e-04	11	105	2	26647393
Interaction	CTSB interactions	SEL1L AMBP ERAP1 REN TWF1 NRP1 P4HA1 PLAU CTSD	3.88e-06	242	102	9	int:CTSB
Cytoband	1q21.1	NBPF8 NBPF9 NBPF10 NBPF14	1.30e-05	62	105	4	1q21.1
Cytoband	Ensembl 112 genes in cytogenetic band chr1q21	TARS2 NBPF20 NBPF19 NBPF9 NBPF10 NBPF14	3.46e-04	404	105	6	chr1q21
GeneFamily	Neuroblastoma breakpoint family	NBPF8 NBPF26 NBPF20 NBPF19 NBPF9 NBPF10 NBPF14	3.03e-12	23	73	7	662
GeneFamily	Cathepsins	CTSD CTSV CTSO	2.77e-05	15	73	3	470
GeneFamily	RNA binding motif containing	PUF60 PABPC5 RAVER2 ZNF638 SPEN	1.70e-03	213	73	5	725
GeneFamily	FKBP prolyl isomerases	FKBP9 FKBP14	2.36e-03	18	73	2	910
GeneFamily	Fibrinogen C domain containing	FGA TNXB	4.54e-03	25	73	2	554
GeneFamily	Calcium voltage-gated channel subunits\|Membrane associated guanylate kinases	MPP3 MPP4	4.91e-03	26	73	2	904
GeneFamily	T cell receptor beta locus at 7q34	TRB TRBV25-1 TRBV10-3	5.25e-03	87	73	3	372
Coexpression	NABA_ECM_REGULATORS	AMBP ITIH2 P4HA1 A2ML1 PLAU MMP10 CTSD CTSV CTSO	4.31e-07	238	103	9	M3468
Coexpression	NABA_ECM_REGULATORS	AMBP ITIH2 P4HA1 A2ML1 PLAU MMP10 CTSD CTSV CTSO	4.96e-07	242	103	9	MM17062
Coexpression	HALLMARK_COAGULATION	FGA PLAU C8A C9 MMP10 CTSV CTSO	1.25e-06	138	103	7	M5946
Coexpression	GSE6259_33D1_POS_DC_VS_CD4_TCELL_DN	ETV5 CP GDE1 ZFYVE9 SBF2 RAVER2 CTSO	6.29e-06	176	103	7	M6757
Coexpression	ZHONG_SECRETOME_OF_LUNG_CANCER_AND_ENDOTHELIUM	CP A2ML1 CTSD CTSV TNXB	9.00e-06	71	103	5	MM1210
Coexpression	RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP	SEL1L RARS1 RHOBTB3 MATR3 ETV5 TWF1 EIF2S1 ASNS PLAU UBE3C NBPF14 USP47	2.66e-05	721	103	12	M10237
Coexpression	RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP	SEL1L RARS1 RHOBTB3 MATR3 AGGF1 TWF1 P4HA1 EIF2S1 ASNS USP47 FKBP14	4.66e-05	644	103	11	M10501
Coexpression	IBRAHIM_NRF2_UP	RARS1 KIAA0232 ETV5 MLH3 ASNS NCOA7 RAB21 SUCO GOLGA4 FKBP14	4.83e-05	533	103	10	M42510
Coexpression	BLUM_RESPONSE_TO_SALIRASIB_UP	SEL1L CDK13 ASNS MMP10 CTSD SUCO GOLGA4	5.29e-05	245	103	7	M7300
Coexpression	DELACROIX_RARG_BOUND_MEF	RARG PARK7 RHOBTB3 CP ITIH2 GDE1 NRP1 CTSD	1.00e-04	366	103	8	M2461
Coexpression	DELACROIX_RARG_BOUND_MEF	RARG PARK7 RHOBTB3 CP ITIH2 GDE1 NRP1 CTSD	1.25e-04	378	103	8	MM1077
Coexpression	GSE13493_DP_VS_CD4INTCD8POS_THYMOCYTE_DN	RARS1 ERAP1 FKBP9 MLH3 FGA NCOA7	1.38e-04	199	103	6	M3313
Coexpression	GSE6681_DELETED_FOXP3_VS_WT_TREG_UP	RARG PABPC5 NRP1 MAMDC2 ZNF638 C9	1.38e-04	199	103	6	M6777
Coexpression	GSE3982_MAST_CELL_VS_NKCELL_UP	RHOBTB3 FKBP9 ETV5 NRP1 FAT1 CTSV	1.38e-04	199	103	6	M5450
Coexpression	GSE3982_NEUTROPHIL_VS_CENT_MEMORY_CD4_TCELL_DN	RARS1 NUP133 ZNF432 UBE3C FBXO21 WDR44	1.42e-04	200	103	6	M5529
Coexpression	ZHONG_SECRETOME_OF_LUNG_CANCER_AND_ENDOTHELIUM	CP CTSD CTSV TNXB	1.43e-04	67	103	4	M1686
Coexpression	HU_FETAL_RETINA_RPE	TYR NBPF19 CTSD NBPF14 CTSV PLS3 GOLGA4	1.54e-04	291	103	7	M39271
CoexpressionAtlas	dev gonad_e13.5_M_SertoliCell_Sox9_top-relative-expression-ranked_1000	SH3TC2 TMC7 ERAP1 RHOBTB3 FKBP9 ETV5 CP REN VPS26A CEMIP2 FAT1 P4HA1 ASNS NCOA7 FBXO21 FKBP14	2.25e-06	880	97	16	gudmap_dev gonad_e13.5_M_SertoliCell_Sox9_1000
ToppCell	COVID-19-kidney-PCT-S3-2\|kidney / Disease (COVID-19 only), tissue and cell type	AMBP CP ITIH2 KCNT2 FGA C8A C9	1.90e-07	174	105	7	5aa2fb631505600f37d2b87b02def7be139dc262
ToppCell	COVID-19-kidney-PCT-S3-2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	AMBP CP ITIH2 KCNT2 FGA C8A C9	2.05e-07	176	105	7	b6497324e3e52f514ce556a3fa0c3011c45dcc7b
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_only / Treatment groups by lineage, cell group, cell type	RHOBTB3 ZNF462 FAT1 MAMDC2 ATRNL1 TNXB PLS3	4.86e-07	200	105	7	a9ff3210127000b3dd9e97136163c98c2b0817d7
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage_4\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	RAP1GAP TMC7 ZNF462 NUP133 RPUSD2 CTSD	2.74e-06	166	105	6	8d5d09f25e8903d481c2097fed435e69d42ccdb5
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	AMBP CP ITIH2 FGA C8A C9	5.44e-06	187	105	6	edb0ab0154542b1c0b3a2c216c4a60f0f06290b3
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic-erythrocytic\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	AMBP CP ITIH2 FGA C8A C9	5.78e-06	189	105	6	7899af78b273d9c7f029d52f7e0cf6df4da41f5e
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic-erythrocytic-erythrocyte\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	AMBP CP ITIH2 FGA C8A C9	5.96e-06	190	105	6	a34293601aefe5fb5c400c14091294b9ddaa195b
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_basal-Basal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	GLB1L3 CP CAPN13 FAT1 MMP10 CTSV	7.12e-06	196	105	6	c5adab88140a465698abcbedc6505a43cae7bfd1
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RAP1GAP RHOBTB3 NEB NRK PLAU CTSD	7.55e-06	198	105	6	4448d13511485a44fe7b549e4b8b6ad7637db624
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	MPP3 RAP1GAP ETV5 CP FAT1 P4HA1	7.99e-06	200	105	6	e8db082aa4d0597500e4f16a5c0ea3e62c6c59ae
ToppCell	background-Hepatocytes\|background / Sample and Cell Type and Tumor Cluster (all cells)	AMBP CP ITIH2 FGA C8A C9	7.99e-06	200	105	6	787d35b5c2f2ad967ae14e99496a0299ac7e72fd
ToppCell	TCGA-Bile_Duct\|World / Sample_Type by Project: Shred V9	AMBP ITIH2 FGA C8A C9	2.04e-05	140	105	5	ca8a0ccbc2f501b759864fe9bb06dc8b44b6b31f
ToppCell	droplet-Liver-Hepatocytes-24m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMBP ITIH2 FGA C8A C9	2.42e-05	145	105	5	f142b86d4da5b71c189da46cbc4beebdc387ffee
ToppCell	10x5'-GI_small-bowel-Lymphocytic_Invariant-Inducer-like-MAIT\|GI_small-bowel / Manually curated celltypes from each tissue	AMBP CP FGA C9 PLS3	2.50e-05	146	105	5	1cb2e157222631e8915d89b255a843d16d7d99cc
ToppCell	droplet-Liver-hepatocytes-3m-Epithelial-Hepatocyte_(Pericentral_and_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CP ITIH2 FGA C8A C9	2.58e-05	147	105	5	00619115b9a1ec2b967c2992043b41974ece63c4
ToppCell	droplet-Liver-Hepatocytes-24m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMBP CP ITIH2 FGA C8A	2.94e-05	151	105	5	e243b6c76e59035f10519a86399b598dd2123f87
ToppCell	droplet-Liver-Hepatocytes-24m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMBP CP ITIH2 FGA C8A	2.94e-05	151	105	5	cdd2ce0969da446616627e3569bbe5a5d9b475bd
ToppCell	facs-Liver\|facs / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMBP CP NRP1 FGA C9	3.65e-05	158	105	5	ea7db6bd9742153ceb6e444892a6d1df9c7fcc96
ToppCell	TCGA-Liver\|World / Sample_Type by Project: Shred V9	AMBP ITIH2 FGA C8A C9	5.77e-05	174	105	5	452932f08cf53e5949672a025d78cecb874aa4b0
ToppCell	droplet-Liver-nan-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPP3 SH3TC2 CEMIP2 NRP1 ATRNL1	6.95e-05	181	105	5	a53f05c4c47465ee62e353716456bd09ab464b23
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEB CSMD3 FAT1 GUCY2F NRK	7.51e-05	184	105	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CACNG5\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF462 NBPF19 RAVER2 NBPF10 NBPF14	7.51e-05	184	105	5	658f2e522055e88c92bc482a845c40f8f5f1a8e3
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEB CSMD3 FAT1 GUCY2F NRK	7.51e-05	184	105	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEB CSMD3 FAT1 GUCY2F NRK	7.51e-05	184	105	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____podocyte-3\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIM46 AMBP CP ITIH2 CAPN13	7.91e-05	186	105	5	29c79b5a29907d4f3f87ad2ca04840c0f15b7d4e
ToppCell	Monocytes-M2-like_CD16+_macrophages\|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis	RHOBTB3 ETV5 NEB NRP1 MAMDC2	8.11e-05	187	105	5	59e31c51183ed4c9a3d0792c8005ea3a12b28dfa
ToppCell	Control-Endothelial-VE_Capillary_A\|Endothelial / Disease state, Lineage and Cell class	MPP3 NRP1 FAT1 PLAU PLS3	8.32e-05	188	105	5	88b3415e33db81726dd29c1f50c886e057af50a0
ToppCell	normal_Lymph_Node-Myeloid_cells-mo-Mac\|normal_Lymph_Node / Location, Cell class and cell subclass	FKBP9 NRP1 MAMDC2 MMP10 CTSD	8.32e-05	188	105	5	e83de94a9b47a6a90e98face887eae031a322af6
ToppCell	droplet-Heart-nan-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPPP CP CEMIP2 ZNF462 NRK	8.53e-05	189	105	5	8e583ec4df0f5b79ce5211cc99ecd8616d180bde
ToppCell	renal_cortex_nuclei-Adult_normal_reference\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	RHOBTB3 CPNE6 ZNF638 FBXO21 GOLGA4	8.53e-05	189	105	5	a48df46274d51e84ffb40264646de7346104efb9
ToppCell	droplet-Heart-nan-3m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPPP CP CEMIP2 ZNF462 NRK	8.53e-05	189	105	5	fb2253b8463d08b3d28e952a31a23dea2c2d986b
ToppCell	LV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	KCNT2 MAMDC2 NRK NCOA7 TNXB	8.96e-05	191	105	5	d36565257ccba8c1bbed2c1c01be66a9cbb5f834
ToppCell	ASK454-Epithelial-Secretory\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	RARG CP EIF2S1 NBPF14 CTSO	8.96e-05	191	105	5	c63c781e7e93265e591cf494cb4ce8ed797c24fb
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RAP1GAP RHOBTB3 NRK PLAU CTSD	9.18e-05	192	105	5	8769b67d1cad1be65da3938f916e5bf88f88f6b8
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RAP1GAP RHOBTB3 NRK PLAU CTSD	9.18e-05	192	105	5	7af2b5240b1fad2177d8022e5f4fc1fe9e8f03b5
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RAP1GAP RHOBTB3 NRK PLAU CTSD	9.18e-05	192	105	5	32e4a180037e516c5cc798cd9dada9385e0f43ae
ToppCell	AT1_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	MPP3 RHOBTB3 ZFYVE9 KCNT2 PLS3	9.18e-05	192	105	5	0444f9e9cef7403e220e862b5a787443d3f5c9ac
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RAP1GAP RHOBTB3 NEB NRK PLAU	9.18e-05	192	105	5	ee27d27e3d269764dbe8711d0b37ff9331a298a9
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MATR3 NBPF19 SBF2 C9 NBPF14	9.41e-05	193	105	5	779276e775cb2492e8dd36436295a536084a6415
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-Reg4/cKit+_deep_crypt_secretory_cells_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIM46 RAP1GAP FKBP9 ETV5 ITIH2	9.41e-05	193	105	5	4aee372ba2c0351b0221d0d468707d1ad21526d6
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-secretory_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIM46 RAP1GAP FKBP9 ETV5 ITIH2	9.41e-05	193	105	5	aaa5042388dc451bff384c6bb237348f08280a08
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-Reg4/cKit+_deep_crypt_secretory_cells_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIM46 RAP1GAP FKBP9 ETV5 ASNS	9.64e-05	194	105	5	0797245ebfa389a6f66874cb0f11297f1456e600
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-secretory_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIM46 RAP1GAP FKBP9 ETV5 ASNS	9.64e-05	194	105	5	0241b4b88d6210b4c1b8aa99db17115b18142f01
ToppCell	5'-Adult-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RAP1GAP NBPF26 NBPF19 NBPF10 FKBP14	9.87e-05	195	105	5	e87b11e3242fdbed2e7f383e6876ec375af32bd4
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CP NRP1 KCNT2 ATRNL1 TNXB	9.87e-05	195	105	5	3c3703f092b6fc1b7333426fb5e2823bfb74bb57
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RAP1GAP RHOBTB3 NEB NRK PLAU	1.04e-04	197	105	5	4ea3f57cd88b8a6bb7cb4b9e3545c0fa8f331886
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_basal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	GLB1L3 CP CAPN13 MMP10 CTSV	1.04e-04	197	105	5	de772bd2b4cda843777ac879b1087e6444199dfb
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Mgp_(Mgp)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ITIH2 GUCY2F NRK TNXB	1.04e-04	103	105	4	39d8cfb899ca88c72ebe021d66cc21ae2eb6a1cc
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Mgp_(Mgp)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ITIH2 GUCY2F NRK TNXB	1.04e-04	103	105	4	01a7baaa0c3903bd00e37717856d2c1ac21bf2c8
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.4\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CAPN13 FAT1 NCOA7 PLAU MMP10	1.06e-04	198	105	5	77517df37dc894c78ef1e2b24dd7ba31f928bdb7
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RAP1GAP RHOBTB3 NRK PLAU CTSD	1.06e-04	198	105	5	688b0eb5534dde40b8630ab8a3252c816711e02e
ToppCell	Bronchus_Control_(B.)-Stromal-TX-Mesothelial-1\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	MPP3 NBPF20 MLH3 KCNT2 C9	1.06e-04	198	105	5	9b1a58fcf818f9c4ae57bbe99655f0a64fe87df7
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RHOBTB3 CP CAPN13 MMP10 GOLGA4	1.11e-04	200	105	5	0f6620a5baace704518d42fa2f3f90751240f7dd
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|Control_saline / Treatment groups by lineage, cell group, cell type	RHOBTB3 FAT1 MAMDC2 ATRNL1 TNXB	1.11e-04	200	105	5	a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Mesenchymal\|3m / Sample Type, Dataset, Time_group, and Cell type.	CP TYR P4HA1 SUCO MORN5	1.11e-04	200	105	5	ce012d738cbec1afdd6af0e10e94b2b6c17b036e
ToppCell	LPS_IL1RA-Epithelial_airway-airway_epithelial-Airway-Club\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CP CAPN13 A2ML1 TMPRSS7 CTSV	1.11e-04	200	105	5	df90b67490cd649de3e3a713762ffbc34a698899
ToppCell	distal-Epithelial-Basal\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GLB1L3 CP CAPN13 A2ML1 MMP10	1.11e-04	200	105	5	5c14f0c09bb8b3daf6d649032e888a7880c52b73
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NRP1 KCNT2 MAMDC2 ATRNL1 TNXB	1.11e-04	200	105	5	58b38f9a484ee94191091a0659ed62ebed2d4a14
Drug	phenylmethylsulfonyl fluoride	REN ITIH2 TYR ZFYVE9 FGA PLAU CTSD CTSV PLS3	2.64e-06	263	101	9	CID000004784
Drug	Catechin-(+,-) hydrate [7295-85-4]; Down 200; 13.8uM; MCF7; HT_HG-U133A	RARG AGGF1 NEB CEMIP2 MLH3 EIF2S1 USP48 FKBP14	2.87e-06	198	101	8	4837_DN
Drug	E64A	CP CTSD CTSV CTSO	1.05e-05	31	101	4	CID000173548
Drug	guanidinium	RARS1 REN NRP1 TLR10 GUCY2F CTSD CTSV GOLGA4	1.37e-05	245	101	8	CID000003520
Drug	AC1NRA23	ZMPSTE24 ZFYVE9 CTSD CTSV CTSO	1.84e-05	73	101	5	CID005287657
Drug	pMEU	ETV5 TYR	1.95e-05	2	101	2	CID000451930
Drug	Om-00-3	REN CTSD	1.95e-05	2	101	2	CID000447068
Drug	CD564	RARG RARS1	1.95e-05	2	101	2	CID000002605
Drug	AcDMH	REN CTSD	1.95e-05	2	101	2	CID003035957
Drug	Cgp 44099	REN CTSD	1.95e-05	2	101	2	CID000131035
Drug	Es 1005	REN CTSD	1.95e-05	2	101	2	CID003082723
Drug	Avermectin B1 [71751-41-2]; Down 200; 4.8uM; HL60; HT_HG-U133A	SEL1L ZFYVE9 KLHL36 CDK13 RPUSD2 CTSD FKBP14	2.73e-05	196	101	7	2519_DN
Drug	Dihydroergocristine mesylate [24730-10-7]; Down 200; 5.6uM; MCF7; HT_HG-U133A	RAD52 RARG CEMIP2 MLH3 KLHL36 USP48 CTSV	2.92e-05	198	101	7	7034_DN
Drug	AC1NUJRK	REN PLAU CTSD	3.71e-05	15	101	3	CID005480852
Drug	S-2648	REN ZFYVE9 FGA PLAU	5.62e-05	47	101	4	CID000123687
Drug	midodrine	CP REN TYR P4HA1	5.62e-05	47	101	4	CID000004195
Drug	Pd 132002	REN CTSD	5.83e-05	3	101	2	CID005487417
Drug	Cgp 38560a	REN CTSD	5.83e-05	3	101	2	CID005487223
Drug	AC1NUZ8A	REN CTSD	5.83e-05	3	101	2	CID005464453
Drug	AC1NAP6W	TYR CTSD	5.83e-05	3	101	2	CID004480500
Drug	AC1LA3FP	CP TYR	5.83e-05	3	101	2	CID000480798
Drug	S 2864	REN CTSD	5.83e-05	3	101	2	CID000192484
Drug	Hexapeptide 5	REN CTSD	5.83e-05	3	101	2	CID000194955
Drug	3,4-didehydroretinoic acid	RARG RARS1 TYR	6.59e-05	18	101	3	CID000447276
Disease	lung non-small cell carcinoma (is_implicated_in)	RAD52 NRP1 JAK1 FAT1 PLAU	1.08e-04	139	99	5	DOID:3908 (is_implicated_in)
Disease	response to bronchodilator, response to corticosteroid	CSMD3 ZNF432	1.11e-04	5	99	2	GO_0031960, GO_0097366
Disease	Ischemia	CP REN PLAU	1.13e-04	28	99	3	C0022116
Disease	Drug toxicity	AMBP CP REN FGA	1.87e-04	84	99	4	C0013221
Disease	Adverse reaction to drug	AMBP CP REN FGA	1.87e-04	84	99	4	C0041755
Disease	squamous cell lung carcinoma	RAD52 NEB GNL1 TNXB MORN5	2.41e-04	165	99	5	EFO_0000708
Disease	sulfatase-modifying factor 1 measurement	AMBP C8A	3.08e-04	8	99	2	EFO_0802098
Disease	Pulmonary Thromboembolisms	FGA PLAU	7.20e-04	12	99	2	C0524702
Disease	adult respiratory distress syndrome (is_implicated_in)	AMBP PLAU	7.20e-04	12	99	2	DOID:11394 (is_implicated_in)
Disease	Pulmonary Embolism	FGA PLAU	7.20e-04	12	99	2	C0034065
Disease	colorectal cancer (is_implicated_in)	RAD52 JAK1 FAT1 MLH3	7.50e-04	121	99	4	DOID:9256 (is_implicated_in)
Disease	Calcium channel blocker use measurement	TRIM46 ERAP1 AS3MT FAT1 SBF2	7.72e-04	213	99	5	EFO_0009930
Disease	Charcot-Marie-Tooth disease type 4	SH3TC2 SBF2	8.48e-04	13	99	2	cv:C4082197
Disease	Psoriasis	ERAP1 CP REN	9.40e-04	57	99	3	C0033860
Disease	Pustulosis of Palms and Soles	ERAP1 CP REN	9.40e-04	57	99	3	C0030246
Disease	cardiotoxicity, response to anthracycline-based chemotherapy	RARG MPP4	9.88e-04	14	99	2	EFO_0005257, EFO_1001482
Disease	thyroid gland papillary carcinoma (is_marker_for)	RAP1GAP PLAU	9.88e-04	14	99	2	DOID:3969 (is_marker_for)
Disease	Prostatic Neoplasms	ETV5 NRP1 JAK1 NCOA7 PLAU CTSD SPEN GOLGA4	1.12e-03	616	99	8	C0033578
Disease	Malignant neoplasm of prostate	ETV5 NRP1 JAK1 NCOA7 PLAU CTSD SPEN GOLGA4	1.12e-03	616	99	8	C0376358
Disease	Osteoporosis, Age-Related	PARK7 REN FGA	1.14e-03	61	99	3	C0001787
Disease	Post-Traumatic Osteoporosis	PARK7 REN FGA	1.14e-03	61	99	3	C0751406
Disease	Osteoporosis, Senile	PARK7 REN FGA	1.14e-03	61	99	3	C0029459
Disease	Osteoporosis	PARK7 REN FGA	1.26e-03	63	99	3	C0029456
Disease	Antibody Deficiency Syndrome	C8A C9	1.47e-03	17	99	2	C0003257
Disease	Hemorrhage	REN PLAU	2.04e-03	20	99	2	C0019080
Disease	Drug-Induced Liver Disease	AMBP PARK7 CP ATP6V1D FGA PLS3	2.44e-03	404	99	6	C0860207
Disease	Drug-Induced Acute Liver Injury	AMBP PARK7 CP ATP6V1D FGA PLS3	2.44e-03	404	99	6	C3658290
Disease	Chemical and Drug Induced Liver Injury	AMBP PARK7 CP ATP6V1D FGA PLS3	2.44e-03	404	99	6	C4277682
Disease	Hepatitis, Drug-Induced	AMBP PARK7 CP ATP6V1D FGA PLS3	2.44e-03	404	99	6	C1262760
Disease	Hepatitis, Toxic	AMBP PARK7 CP ATP6V1D FGA PLS3	2.44e-03	404	99	6	C0019193
Disease	Chemically-Induced Liver Toxicity	AMBP PARK7 CP ATP6V1D FGA PLS3	2.44e-03	404	99	6	C4279912
Disease	small cell lung carcinoma	RAD52 NRP1 A2ML1	2.50e-03	80	99	3	EFO_0000702
Disease	Immunologic Deficiency Syndromes	C8A C9	2.69e-03	23	99	2	C0021051
Disease	Albuminuria	CP REN	2.93e-03	24	99	2	C0001925
Disease	migraine disorder, Headache	MYO1H TARS2 ZNF462	3.06e-03	86	99	3	HP_0002315, MONDO_0005277
Disease	Ataxia	RARS1 CP	3.18e-03	25	99	2	C0004134
Disease	Malignant neoplasm of breast	TRIML1 RAP1GAP RARG KCNT2 GUCY2F NUP133 ZNF432 MMP10 SPEN PLS3	3.27e-03	1074	99	10	C0006142
Disease	Kidney Diseases	REN FGA CTSD	3.27e-03	88	99	3	C0022658

Protein segments in the cluster

Peptide	Gene	Start	Entry
GAYEKTDTDGKFLYH	AMBP	96	P02760
GSDELTQGYIYFHKA	ASNS	366	P08243
LYHDISGDTSGDYRK	ANXA11	481	P50995
DGSVSYTGFHLEYKA	CSMD3	1681	Q7Z407
AKFINDYGTHYITSG	C8A	331	P07357
DAGHSSFQFYKSGIY	CTSV	251	O60911
YKHSNGSYSAFGERD	A2ML1	1016	A8K2U0
GFSYDENTGLYFDHS	AGGF1	206	Q8N302
LLGSYSDLHYGFLED	CAPN13	176	Q6MZZ7
GDTYVSTSDYKDNFG	CDK13	1326	Q14004
LVYDYDSSGKHDFIG	CPNE6	226	O95741
SEVTGHSKGYGFVEY	RAVER2	176	Q9HCJ3
EAESYAESVGAKHYH	RAB21	146	Q9UL25
FVCNDKSSGYHYGVS	RARG	91	P13631
KDGSYHEDVGYGVSE	RAD52	116	P43351
HIYSGTLMDYKDDEG	JAK1	596	P23458
LNEEGHYIYVDTSFG	MAMDC2	46	Q7Z304
SHGITYYKEHEGAIY	CP	121	P00450
SFAVKEHGDFYSFDG	MMP10	161	P09238
ADIGTNGEFYYSFKD	FAT1	176	Q14517
DVGRYFSEFTGTHYI	FBXO21	581	O94952
HYEGYLEKDGSLFHS	FKBP14	51	Q9NWM8
YTEAFVDSGGDKTYS	NUP133	196	Q8WUM0
YHSNSGKEEGFELYS	DTD2	106	Q96FN9
GHAGTIYKDFVYISG	KLHL36	436	Q8N4N3
FGETSHNYHKFDSEY	MATR3	236	P43243
NSGKGFIDGHYKDYF	ITIH2	921	P19823
ASFYGHSEYELAIAG	FN3KRP	236	Q9HA64
YYDSGEDTSCKGHID	SBF2	1776	Q86WG5
YKGGNLYHTDVSLFG	GOLGA4	2156	Q13439
FGKHSGIVTSYDYDA	GLB1L3	356	Q8NCI6
GYGAYDAFKHAVSDP	EIF2S1	146	P05198
YAGNLSETFHGFYKS	ERAP1	151	Q9NZ08
DTSEGAVHYFYDESG	PCNX3	656	Q9H6A9
GTQHSYSEEEKYAFV	PLS3	116	P13797
EGHYYGKSELESGKF	KIAA0232	1161	Q92628
KEFELSGYISSEAHY	MLH3	231	Q9UHC1
GGHYTYSENRVEKDG	PARK7	136	Q99497
YGEYKGHLYGTSVDA	MPP4	496	Q96JB8
SFQDYLGKIHGAYSS	GNL1	151	P36915
GYFSSSHEGFSYEKD	ETV5	316	P41161
AEYEGKSFTYASFHA	KCNT2	501	Q6UVM3
YNLFASGEGDYSTRH	P4HA1	486	P13674
DNGSKGYAYVHFDSL	PABPC5	141	Q96DU9
DYETHGAGFSIRYEI	NRP1	126	O14786
YHYNGTFLDGTLFDS	FKBP9	171	O95302
VNTFDEKSYYESHLG	GDE1	301	Q9NZC3
YVKNGTSFDIHYGSG	CTSD	131	P07339
GSHDVYKVETIGDAY	GUCY2F	921	P51841
KHGGELYFSDVYTSL	AS3MT	176	Q9HBK9
GGYGHTSVYDEITKS	ATRNL1	466	Q5VV63
DVDYKGGYRHATFVD	CEMIP2	556	Q9UHN6
HDIDGSVTGYKDAYV	CEMIP2	951	Q9UHN6
AYAEYHFRVGSEAEG	FGA	736	P02671
EGSKRSSHSNAYFYG	ZMPSTE24	256	O75844
EKGEYFAFLETYGTH	C9	331	P02748
HSLDDFYIGKYFGGV	RHOBTB3	176	O94955
FLEHGEYKENLYGTS	MPP3	451	Q13368
GKEEAYRGYGSHTAN	NRK	1011	Q7Z2Y5
EHFAETSYYFEGGLR	RPUSD2	126	Q8IZ73
STEYGFYHDFFLGKE	TARS2	156	Q9BW92
VKSDGGYTYDTSDLA	RARS1	376	P54136
KAGYGEYSEDVHLHT	TRIM46	511	Q7Z4K8
YEGNGHFYRGKASTD	PLAU	71	P00749
HKGYGFIEYEKAQSS	PUF60	266	Q9UHX1
FGGKAYLDHNSFDYS	TLR10	281	Q9BXR5
IKLGDYHFYGFGTDV	SEL1L	631	Q9UBV2
FKFSDHYYGTGETFL	NCOA7	851	Q8NI08
YGSSFYALEEKHVGF	NBPF8	771	Q3BBV2
YGSSFYALEEKHVGF	NBPF9	806	P0DPF3
YGSSFYALEEKHVGF	NBPF10	806	Q6P3W6
YGSSFYALEEKHVGF	NBPF10	2026	Q6P3W6
YGSSFYALEEKHVGF	NBPF10	3246	Q6P3W6
YGSSFYALEEKHVGF	NBPF14	466	Q5TI25
YGSSFYALEEKHVGF	NBPF19	1511	A0A087WUL8
YGSSFYALEEKHVGF	NBPF19	2731	A0A087WUL8
YGSSFYALEEKHVGF	NBPF20	191	P0DPF2
YGSSFYALEEKHVGF	NBPF20	1411	P0DPF2
YGSSFYALEEKHVGF	NBPF20	2631	P0DPF2
YGSSFYALEEKHVGF	NBPF20	3851	P0DPF2
YGSSFYALEEKHVGF	NBPF20	5071	P0DPF2
YGSSFYALEEKHVGF	NBPF26	766	B4DH59
FHLGGKEYTLTSADY	REN	336	P00797
GKEHFNYYSLDAALG	RAP1GAP	96	P47736
HEGYADHFKSLYDFS	SH3TC2	476	Q8TF17
LLDSRGAFHTKGYYA	SKIV2L	506	Q15477
GAFHTKGYYAAVEAK	SKIV2L	511	Q15477
HSGFSIKGYSAYDFS	CTSO	211	P43234
HYSYGVKDTDKGEVS	TRBV10-3	66	A0A0K0K1G6
VHSSGELFQEYRYGD	SPEN	3296	Q96T58
IGSDKGCSQYFYAEH	TMPRSS7	241	Q7RTY8
HYHEGTDSYELTGLA	ATP6V1D	111	Q9Y5K8
SDHRYLVTLYGFSDG	TNXB	1941	P22105
GGHYYACIKSFSDEQ	USP47	501	Q96K76
GDFFISSKDLGYDYS	TYR	436	P14679
HDFTYLVSGSEDKYV	WDR44	796	Q5JSH3
DFSNMGEVYHSSYKG	SUCO	1146	Q9UBS9
HYSYGVNSTEKGDLS	TRB	66	P0DTU4
LDYESGHIAFYNGTD	TRIML1	411	Q8N9V2
VDESGYVSGYKHAGT	TPPP	196	O94811
VEKHYLFYDGESVSG	VPS26A	36	O75436
DGKSFLHGNYEELYS	ZNF432	161	O94892
SKLGGYFTAVYADEH	ZNF462	1801	Q96JM2
HYSYGVNSTEKGDLS	TRBV25-1	66	A0A075B6N4
YVEHKGGSYVYELSA	USP48	326	Q86UV5
YGHASKYGYTEDPLE	ZNF638	211	Q14966
GSKEHGGFLYVTSTY	ZFYVE9	1026	O95405
YKHSHEGDYLESIVF	TWF1	241	Q12792
EETSLFYGHYTIDGV	TMC7	241	Q7Z402
LKSFTNYSGGYSADH	UBE3C	976	Q15386
TKSFYEGAAEYVSHE	PP2D1	586	A8MPX8
GTYTFSDGLHYDEKN	MORN5	66	Q5VZ52
YRTEDGSAKAGSDYE	SLC8A2	431	Q9UPR5
HYAGEVTYCTKGFLE	MYO1H	516	Q8N1T3
YSDGGVFAVSTAYKH	NEB	6566	P20929