Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	negative regulation of NAD(P)H oxidase activity	INS INS-IGF2	3.50e-05	3	71	2	GO:0033861
GeneOntologyBiologicalProcess	regulation of nucleotide catabolic process	INS JMJD8 MTCH2 INS-IGF2	6.59e-05	63	71	4	GO:0030811
GeneOntologyBiologicalProcess	regulation of purine nucleotide catabolic process	INS JMJD8 MTCH2 INS-IGF2	6.59e-05	63	71	4	GO:0033121
GeneOntologyBiologicalProcess	regulation of glycolytic process	INS JMJD8 MTCH2 INS-IGF2	6.59e-05	63	71	4	GO:0006110
GeneOntologyBiologicalProcess	negative regulation of glycogen catabolic process	INS INS-IGF2	6.98e-05	4	71	2	GO:0045818
GeneOntologyBiologicalProcess	positive regulation of nitric oxide mediated signal transduction	INS INS-IGF2	6.98e-05	4	71	2	GO:0010750
GeneOntologyBiologicalProcess	positive regulation of lipid kinase activity	INS INS-IGF2	1.16e-04	5	71	2	GO:0090218
GeneOntologyBiologicalProcess	negative regulation of respiratory burst involved in inflammatory response	INS INS-IGF2	1.74e-04	6	71	2	GO:0060266
GeneOntologyBiologicalProcess	regulation of NAD(P)H oxidase activity	INS INS-IGF2	1.74e-04	6	71	2	GO:0033860
GeneOntologyBiologicalProcess	regulation of carbohydrate catabolic process	INS JMJD8 MTCH2 INS-IGF2	1.84e-04	82	71	4	GO:0043470
GeneOntologyBiologicalProcess	negative regulation of feeding behavior	INS INS-IGF2 NMU	1.98e-04	33	71	3	GO:2000252
GeneOntologyBiologicalProcess	cell-cell fusion	FLT3LG INS ADAM9 INS-IGF2	2.11e-04	85	71	4	GO:0140253
GeneOntologyBiologicalProcess	syncytium formation by plasma membrane fusion	FLT3LG INS ADAM9 INS-IGF2	2.11e-04	85	71	4	GO:0000768
GeneOntologyBiologicalProcess	positive regulation of dendritic spine maintenance	INS INS-IGF2	2.43e-04	7	71	2	GO:1902952
GeneOntologyBiologicalProcess	syncytium formation	FLT3LG INS ADAM9 INS-IGF2	2.52e-04	89	71	4	GO:0006949
GeneOntologyBiologicalProcess	regulation of ATP metabolic process	INS JMJD8 MTCH2 INS-IGF2	2.75e-04	91	71	4	GO:1903578
GeneOntologyBiologicalProcess	negative regulation of respiratory burst	INS INS-IGF2	3.23e-04	8	71	2	GO:0060268
GeneOntologyBiologicalProcess	peptide hormone processing	INS BACE2 INS-IGF2	3.79e-04	41	71	3	GO:0016486
GeneOntologyBiologicalProcess	respiratory burst	INS CD55 INS-IGF2	4.37e-04	43	71	3	GO:0045730
GeneOntologyBiologicalProcess	negative regulation of behavior	INS INS-IGF2 NMU	5.00e-04	45	71	3	GO:0048521
GeneOntologyBiologicalProcess	positive regulation of respiratory burst	INS INS-IGF2	5.16e-04	10	71	2	GO:0060267
GeneOntologyBiologicalProcess	signaling receptor ligand precursor processing	INS BACE2 INS-IGF2	5.34e-04	46	71	3	GO:0140448
GeneOntologyBiologicalProcess	glycolytic process	INS JMJD8 MTCH2 INS-IGF2	5.65e-04	110	71	4	GO:0006096
GeneOntologyBiologicalProcess	regulation of purine nucleotide metabolic process	INS JMJD8 MTCH2 INS-IGF2	6.05e-04	112	71	4	GO:1900542
GeneOntologyBiologicalProcess	regulation of nucleotide metabolic process	INS JMJD8 MTCH2 INS-IGF2	6.26e-04	113	71	4	GO:0006140
GeneOntologyBiologicalProcess	regulation of lipid kinase activity	INS INS-IGF2	6.30e-04	11	71	2	GO:0043550
GeneOntologyBiologicalProcess	regulation of respiratory burst involved in inflammatory response	INS INS-IGF2	6.30e-04	11	71	2	GO:0060264
GeneOntologyBiologicalProcess	nitric oxide-cGMP-mediated signaling	INS INS-IGF2	6.30e-04	11	71	2	GO:0038060
GeneOntologyBiologicalProcess	ADP catabolic process	INS JMJD8 MTCH2 INS-IGF2	6.47e-04	114	71	4	GO:0046032
GeneOntologyBiologicalProcess	purine nucleoside diphosphate catabolic process	INS JMJD8 MTCH2 INS-IGF2	7.13e-04	117	71	4	GO:0009137
GeneOntologyBiologicalProcess	purine ribonucleoside diphosphate catabolic process	INS JMJD8 MTCH2 INS-IGF2	7.13e-04	117	71	4	GO:0009181
GeneOntologyBiologicalProcess	insulin processing	INS INS-IGF2	7.54e-04	12	71	2	GO:0030070
GeneOntologyBiologicalProcess	pyridine nucleotide catabolic process	INS JMJD8 MTCH2 INS-IGF2	7.60e-04	119	71	4	GO:0019364
GeneOntologyBiologicalProcess	ADP metabolic process	INS JMJD8 MTCH2 INS-IGF2	7.84e-04	120	71	4	GO:0046031
GeneOntologyBiologicalProcess	ribonucleoside diphosphate catabolic process	INS JMJD8 MTCH2 INS-IGF2	8.08e-04	121	71	4	GO:0009191
GeneOntologyBiologicalProcess	pyridine-containing compound catabolic process	INS JMJD8 MTCH2 INS-IGF2	8.60e-04	123	71	4	GO:0072526
GeneOntologyBiologicalProcess	nucleoside diphosphate catabolic process	INS JMJD8 MTCH2 INS-IGF2	8.86e-04	124	71	4	GO:0009134
GeneOntologyBiologicalProcess	neuron projection maintenance	INS INS-IGF2	8.89e-04	13	71	2	GO:1990535
GeneOntologyBiologicalProcess	respiratory burst involved in inflammatory response	INS INS-IGF2	8.89e-04	13	71	2	GO:0002536
GeneOntologyBiologicalProcess	positive regulation of cytokine production	SEMA7A PTPRJ TNFSF9 INS CD55 ULBP2 INS-IGF2 IL27	8.93e-04	586	71	8	GO:0001819
GeneOntologyBiologicalProcess	regulation of intrinsic apoptotic signaling pathway	FZD1 INS IL20RA MTCH2 PTTG1IP	8.93e-04	216	71	5	GO:2001242
GeneOntologyBiologicalProcess	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	PTPRJ INS UNC5B WNT16 INS-IGF2	9.12e-04	217	71	5	GO:0051897
GeneOntologyBiologicalProcess	regulation of nitric oxide mediated signal transduction	INS INS-IGF2	1.04e-03	14	71	2	GO:0010749
GeneOntologyBiologicalProcess	regulation of glycogen catabolic process	INS INS-IGF2	1.04e-03	14	71	2	GO:0005981
GeneOntologyBiologicalProcess	myoblast fusion	FLT3LG INS INS-IGF2	1.05e-03	58	71	3	GO:0007520
GeneOntologyBiologicalProcess	regulation of apoptotic signaling pathway	FZD1 INS UNC5B WNT16 IL20RA MTCH2 PTTG1IP	1.11e-03	467	71	7	GO:2001233
GeneOntologyBiologicalProcess	alpha-beta T cell activation	CDH26 INS CD55 INS-IGF2 IL27	1.11e-03	227	71	5	GO:0046631
GeneOntologyBiologicalProcess	purine nucleoside diphosphate metabolic process	INS JMJD8 MTCH2 INS-IGF2	1.12e-03	132	71	4	GO:0009135
GeneOntologyBiologicalProcess	purine ribonucleoside diphosphate metabolic process	INS JMJD8 MTCH2 INS-IGF2	1.12e-03	132	71	4	GO:0009179
GeneOntologyBiologicalProcess	ER overload response	INS INS-IGF2	1.19e-03	15	71	2	GO:0006983
GeneOntologyBiologicalProcess	regulation of carbohydrate metabolic process	SLC45A3 INS JMJD8 MTCH2 INS-IGF2	1.20e-03	231	71	5	GO:0006109
GeneOntologyBiologicalProcess	regulation of feeding behavior	INS INS-IGF2 NMU	1.22e-03	61	71	3	GO:0060259
GeneOntologyBiologicalProcess	negative regulation of glycogen metabolic process	INS INS-IGF2	1.36e-03	16	71	2	GO:0070874
GeneOntologyBiologicalProcess	positive regulation of glucose metabolic process	SLC45A3 INS INS-IGF2	1.40e-03	64	71	3	GO:0010907
GeneOntologyBiologicalProcess	pyruvate metabolic process	INS JMJD8 MTCH2 INS-IGF2	1.46e-03	142	71	4	GO:0006090
GeneOntologyBiologicalProcess	ribonucleoside diphosphate metabolic process	INS JMJD8 MTCH2 INS-IGF2	1.50e-03	143	71	4	GO:0009185
GeneOntologyBiologicalProcess	intrinsic apoptotic signaling pathway	FZD1 INS IL20RA MTCH2 PTTG1IP INS-IGF2	1.52e-03	361	71	6	GO:0097193
GeneOntologyBiologicalProcess	positive regulation of glycogen biosynthetic process	INS INS-IGF2	1.72e-03	18	71	2	GO:0045725
GeneOntologyBiologicalProcess	regulation of dendritic spine maintenance	INS INS-IGF2	1.72e-03	18	71	2	GO:1902950
GeneOntologyBiologicalProcess	negative regulation of acute inflammatory response	INS INS-IGF2	1.72e-03	18	71	2	GO:0002674
GeneOntologyBiologicalProcess	regulation of amino acid metabolic process	INS INS-IGF2	1.72e-03	18	71	2	GO:0006521
GeneOntologyBiologicalProcess	fatty acid homeostasis	INS INS-IGF2	1.72e-03	18	71	2	GO:0055089
GeneOntologyBiologicalProcess	nucleoside diphosphate metabolic process	INS JMJD8 MTCH2 INS-IGF2	1.75e-03	149	71	4	GO:0009132
GeneOntologyCellularComponent	extracellular matrix	ZP1 IGFALS SEMA7A ADAMTS4 MMP28 INS EFEMP2 NID1 CBLN1 INS-IGF2 FBN3	1.24e-05	656	71	11	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	ZP1 IGFALS SEMA7A ADAMTS4 MMP28 INS EFEMP2 NID1 CBLN1 INS-IGF2 FBN3	1.27e-05	658	71	11	GO:0030312
GeneOntologyCellularComponent	collagen-containing extracellular matrix	ZP1 SEMA7A ADAMTS4 MMP28 INS EFEMP2 NID1 CBLN1 INS-IGF2	7.45e-05	530	71	9	GO:0062023
GeneOntologyCellularComponent	microfibril	EFEMP2 FBN3	8.66e-04	13	71	2	GO:0001527
GeneOntologyCellularComponent	endoplasmic reticulum lumen	INS JMJD8 TMEM43 DNAJC1 INS-IGF2 IL27	9.23e-04	332	71	6	GO:0005788
MousePheno	abnormal capillary morphology	INS UNC5B JMJD8 NID1 INS-IGF2	2.37e-05	93	52	5	MP:0003658
Domain	cEGF	SCUBE2 EFEMP2 NID1 FBN3	2.01e-06	26	66	4	IPR026823
Domain	cEGF	SCUBE2 EFEMP2 NID1 FBN3	2.01e-06	26	66	4	PF12662
Domain	EGF_CA	SCUBE2 SUSD1 EFEMP2 NID1 FBN3	1.32e-05	86	66	5	PF07645
Domain	EGF_Ca-bd_CS	SCUBE2 SUSD1 EFEMP2 NID1 FBN3	2.37e-05	97	66	5	IPR018097
Domain	EGF_CA	SCUBE2 SUSD1 EFEMP2 NID1 FBN3	2.61e-05	99	66	5	PS01187
Domain	ASX_HYDROXYL	SCUBE2 SUSD1 EFEMP2 NID1 FBN3	2.74e-05	100	66	5	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	SCUBE2 SUSD1 EFEMP2 NID1 FBN3	3.63e-05	106	66	5	IPR000152
Domain	Peptidase_S28	DPP7 PRSS16	3.68e-05	3	66	2	IPR008758
Domain	Peptidase_S28	DPP7 PRSS16	3.68e-05	3	66	2	PF05577
Domain	EGF_CA	SCUBE2 SUSD1 EFEMP2 NID1 FBN3	7.12e-05	122	66	5	SM00179
Domain	EGF-like_Ca-bd_dom	SCUBE2 SUSD1 EFEMP2 NID1 FBN3	7.69e-05	124	66	5	IPR001881
Domain	EGF_3	SCUBE2 SUSD1 ADAM9 EFEMP2 NID1 FBN3	1.80e-04	235	66	6	PS50026
Domain	EGF	SCUBE2 SUSD1 ADAM9 EFEMP2 NID1 FBN3	1.80e-04	235	66	6	SM00181
Domain	Growth_fac_rcpt_	SCUBE2 SUSD1 EFEMP2 NID1 FBN3	2.26e-04	156	66	5	IPR009030
Domain	EGF-like_dom	SCUBE2 SUSD1 ADAM9 EFEMP2 NID1 FBN3	2.46e-04	249	66	6	IPR000742
Domain	EGF_1	SCUBE2 SUSD1 ADAM9 EFEMP2 NID1 FBN3	2.80e-04	255	66	6	PS00022
Domain	EGF-like_CS	SCUBE2 SUSD1 ADAM9 EFEMP2 NID1 FBN3	3.17e-04	261	66	6	IPR013032
Domain	EGF_2	SCUBE2 SUSD1 ADAM9 EFEMP2 NID1 FBN3	3.43e-04	265	66	6	PS01186
Domain	-	INS INS-IGF2	4.36e-04	9	66	2	1.10.100.10
Domain	Insulin	INS INS-IGF2	5.43e-04	10	66	2	PF00049
Domain	Insulin	INS INS-IGF2	6.63e-04	11	66	2	IPR004825
Domain	-	SUSD1 NID1	6.63e-04	11	66	2	2.40.155.10
Domain	GFP-like	SUSD1 NID1	6.63e-04	11	66	2	IPR023413
Domain	Insulin-like	INS INS-IGF2	6.63e-04	11	66	2	IPR016179
Domain	IlGF	INS INS-IGF2	6.63e-04	11	66	2	SM00078
Domain	EGF_3	SCUBE2 NID1	7.93e-04	12	66	2	PF12947
Domain	EGF_dom	SCUBE2 NID1	7.93e-04	12	66	2	IPR024731
Domain	MetalloPept_cat_dom	ADAMTS4 MMP28 ADAM9	2.95e-03	81	66	3	IPR024079
Domain	-	ADAMTS4 MMP28 ADAM9	2.95e-03	81	66	3	3.40.390.10
Domain	ACR	ADAMTS4 ADAM9	4.08e-03	27	66	2	SM00608
Domain	ADAM_Cys-rich	ADAMTS4 ADAM9	4.08e-03	27	66	2	IPR006586
Domain	ZINC_PROTEASE	ADAMTS4 MMP28 ADAM9	5.05e-03	98	66	3	PS00142
Domain	JMJC	JMJD8 KDM2A	5.70e-03	32	66	2	PS51184
Domain	JmjC_dom	JMJD8 KDM2A	5.70e-03	32	66	2	IPR003347
Domain	JmjC	JMJD8 KDM2A	6.05e-03	33	66	2	SM00558
Domain	Cadherin_CS	CDH26 PCDHA8 PCDHA5	6.78e-03	109	66	3	IPR020894
Domain	CADHERIN_1	CDH26 PCDHA8 PCDHA5	7.48e-03	113	66	3	PS00232
Domain	Cadherin	CDH26 PCDHA8 PCDHA5	7.48e-03	113	66	3	PF00028
Domain	Cadherin_tail	PCDHA8 PCDHA5	7.56e-03	37	66	2	PF15974
Domain	Cadherin_CBD	PCDHA8 PCDHA5	7.56e-03	37	66	2	IPR031904
Domain	CADHERIN_2	CDH26 PCDHA8 PCDHA5	7.67e-03	114	66	3	PS50268
Domain	-	CDH26 PCDHA8 PCDHA5	7.67e-03	114	66	3	2.60.40.60
Domain	CA	CDH26 PCDHA8 PCDHA5	7.85e-03	115	66	3	SM00112
Domain	Cadherin-like	CDH26 PCDHA8 PCDHA5	8.04e-03	116	66	3	IPR015919
Domain	Peptidase_M12B_N	ADAMTS4 ADAM9	8.38e-03	39	66	2	IPR002870
Domain	Pep_M12B_propep	ADAMTS4 ADAM9	8.38e-03	39	66	2	PF01562
Domain	Cadherin	CDH26 PCDHA8 PCDHA5	8.43e-03	118	66	3	IPR002126
Domain	DISINTEGRIN_1	ADAMTS4 ADAM9	8.80e-03	40	66	2	PS00427
Domain	LDLR_class-A_CS	LRP12 LRP11	8.80e-03	40	66	2	IPR023415
Domain	Reprolysin	ADAMTS4 ADAM9	8.80e-03	40	66	2	PF01421
Domain	ADAM_MEPRO	ADAMTS4 ADAM9	8.80e-03	40	66	2	PS50215
Domain	DISINTEGRIN_2	ADAMTS4 ADAM9	8.80e-03	40	66	2	PS50214
Domain	Peptidase_M12B	ADAMTS4 ADAM9	8.80e-03	40	66	2	IPR001590
Domain	Disintegrin_dom	ADAMTS4 ADAM9	9.23e-03	41	66	2	IPR001762
Domain	EGF	SCUBE2 NID1 FBN3	1.01e-02	126	66	3	PF00008
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	SIAE LRP12 GINM1 PTPRJ TNFSF9 RPN2 ADAM9 JMJD8 LRP11 TM9SF3 CD55 ULBP2 NID1 TMEM43 DNAJC1 BACE2 MTCH2 ALG1	2.37e-11	1201	71	18	35696571
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	LRRC25 GINM1 ADAMTS4 SUSD1 MMP28 UNC5B RNASE7 EFEMP2 TM9SF3 PSCA IL20RA ULBP2 TMEM43 BACE2 ALG1	1.13e-09	985	71	15	12975309
Pubmed	Amino acid sequence of the variable region of M149 mouse myeloma light chain: comparison with the nucleotide sequence of K2 and K3 clones.	IGKV1-39 IGKV1-8 IGKV1D-39	1.33e-06	11	71	3	6795447
Pubmed	Multiple related immunoglobulin variable-region genes identified by cloning and sequence analysis.	IGKV1-39 IGKV1-8 IGKV1D-39	1.33e-06	11	71	3	279004
Pubmed	Developmental expression of metalloproteases ADAM 9, 10, and 17 becomes restricted to divergent pancreatic compartments.	INS ADAM9 INS-IGF2	1.33e-06	11	71	3	15739225
Pubmed	Organization and complete sequence of identical embryonic and plasmacytoma kappa V-region genes.	IGKV1-39 IGKV1-8 IGKV1D-39	1.33e-06	11	71	3	6767723
Pubmed	Mart1 is located on mouse chromosome 19 and is excluded as a candidate for ep and ru.	ZP1 INS INS-IGF2	1.77e-06	12	71	3	9107690
Pubmed	Mapping of murine diabetogenic gene mody on chromosome 7 at D7Mit258 and its involvement in pancreatic islet and beta cell development during the perinatal period.	INS INS-IGF2	4.11e-06	2	71	2	9593767
Pubmed	SGLT1/2 inhibition improves glycemic control and multi-organ protection in type 1 diabetes.	INS INS-IGF2	4.11e-06	2	71	2	37520739
Pubmed	Neuritic dystrophy and neuronopathy in Akita (Ins2(Akita)) diabetic mouse sympathetic ganglia.	INS INS-IGF2	4.11e-06	2	71	2	19111542
Pubmed	Investigating the protective effects of estrogen on β-cell health and the progression of hyperglycemia-induced atherosclerosis.	INS INS-IGF2	4.11e-06	2	71	2	35830687
Pubmed	Growth factors and medium hyperglycemia induce Sox9+ ductal cell differentiation into β cells in mice with reversal of diabetes.	INS INS-IGF2	4.11e-06	2	71	2	26733677
Pubmed	Progressive Thinning of Retinal Nerve Fiber Layer/Ganglion Cell Layer (RNFL/GCL) as Biomarker and Pharmacological Target of Diabetic Retinopathy.	INS INS-IGF2	4.11e-06	2	71	2	37628852
Pubmed	Proinsulin I and II gene expression in inbred mouse strains.	INS INS-IGF2	4.11e-06	2	71	2	2608062
Pubmed	Decreased Satellite Cell Number and Function in Humans and Mice With Type 1 Diabetes Is the Result of Altered Notch Signaling.	INS INS-IGF2	4.11e-06	2	71	2	27335233
Pubmed	Expression of preproinsulin-2 gene shapes the immune response to preproinsulin in normal mice.	INS INS-IGF2	4.11e-06	2	71	2	14688305
Pubmed	Bioinformatics Analysis of Weighted Genes in Diabetic Retinopathy.	INS INS-IGF2	4.11e-06	2	71	2	30480744
Pubmed	The implications of hyperoxia, type 1 diabetes and sex on cardiovascular physiology in mice.	INS INS-IGF2	4.11e-06	2	71	2	34845324
Pubmed	SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice.	INS INS-IGF2	4.11e-06	2	71	2	24226524
Pubmed	Genetic control of insulin receptors.	INS INS-IGF2	4.11e-06	2	71	2	7031649
Pubmed	Thymic expression of mutated B16:A preproinsulin messenger RNA does not reverse acceleration of NOD diabetes associated with insulin 2 (thymic expressed insulin) knockout.	INS INS-IGF2	4.11e-06	2	71	2	16289958
Pubmed	Insulin rescues impaired spermatogenesis via the hypothalamic-pituitary-gonadal axis in Akita diabetic mice and restores male fertility.	INS INS-IGF2	4.11e-06	2	71	2	22522616
Pubmed	Identification of novel targets of diabetic nephropathy and PEDF peptide treatment using RNA-seq.	INS INS-IGF2	4.11e-06	2	71	2	27855634
Pubmed	Localization of the rat insulin I gene (INS1) to chromosome 1q55 by fluorescence in situ hybridization.	INS INS-IGF2	4.11e-06	2	71	2	1346376
Pubmed	Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease.	INS INS-IGF2	4.11e-06	2	71	2	26203118
Pubmed	Overexpression of catalase prevents hypertension and tubulointerstitial fibrosis and normalization of renal angiotensin-converting enzyme-2 expression in Akita mice.	INS INS-IGF2	4.11e-06	2	71	2	23552863
Pubmed	Maternal Chromium Restriction Leads to Glucose Metabolism Imbalance in Mice Offspring through Insulin Signaling and Wnt Signaling Pathways.	INS INS-IGF2	4.11e-06	2	71	2	27782077
Pubmed	Specific dynamic and noninvasive labeling of pancreatic beta cells in reporter mice.	INS INS-IGF2	4.11e-06	2	71	2	16283623
Pubmed	Type 1 diabetic Akita mice have low bone mass and impaired fracture healing.	INS INS-IGF2	4.11e-06	2	71	2	33662611
Pubmed	Identification of novel diabetes impaired miRNA-transcription factor co-regulatory networks in bone marrow-derived Lin-/VEGF-R2+ endothelial progenitor cells.	INS INS-IGF2	4.11e-06	2	71	2	29995913
Pubmed	Maternal diabetes adversely affects preovulatory oocyte maturation, development, and granulosa cell apoptosis.	INS INS-IGF2	4.11e-06	2	71	2	15718275
Pubmed	Insulin-Deficient Mouse β-Cells Do Not Fully Mature but Can Be Remedied Through Insulin Replacement by Islet Transplantation.	INS INS-IGF2	4.11e-06	2	71	2	29029025
Pubmed	Mutant INS-gene induced diabetes of youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transport.	INS INS-IGF2	4.11e-06	2	71	2	20948967
Pubmed	Global transcriptional programs in peripheral nerve endoneurium and DRG are resistant to the onset of type 1 diabetic neuropathy in Ins2 mice.	INS INS-IGF2	4.11e-06	2	71	2	20520806
Pubmed	Loss of cholinergic and dopaminergic amacrine cells in streptozotocin-diabetic rat and Ins2Akita-diabetic mouse retinas.	INS INS-IGF2	4.11e-06	2	71	2	16799061
Pubmed	Prevalence and Clinical Characteristics of PDX1 Variant Induced Diabetes in Chinese Early-Onset Type 2 Diabetes.	INS INS-IGF2	4.11e-06	2	71	2	37279936
Pubmed	An imprinted GFP insertion reveals long-range epigenetic regulation in embryonic lineages.	INS INS-IGF2	4.11e-06	2	71	2	19778534
Pubmed	Insulin Knockout Mice Have Extended Survival but Volatile Blood Glucose Levels on Leptin Therapy.	INS INS-IGF2	4.11e-06	2	71	2	26696124
Pubmed	In Vivo Capillary Structure and Blood Cell Flux in the Normal and Diabetic Mouse Eye.	INS INS-IGF2	4.11e-06	2	71	2	35138346
Pubmed	Compensatory hyperinsulinemia in high-fat diet-induced obese mice is associated with enhanced insulin translation in islets.	INS INS-IGF2	4.11e-06	2	71	2	25686499
Pubmed	Parental diabetes: the Akita mouse as a model of the effects of maternal and paternal hyperglycemia in wildtype offspring.	INS INS-IGF2	4.11e-06	2	71	2	23209676
Pubmed	Hyper-Variability in Circulating Insulin, High Fat Feeding Outcomes, and Effects of Reducing Ins2 Dosage in Male Ins1-Null Mice in a Specific Pathogen-Free Facility.	INS INS-IGF2	4.11e-06	2	71	2	27055260
Pubmed	Proinsulin C-peptide activates cAMP response element-binding proteins through the p38 mitogen-activated protein kinase pathway in mouse lung capillary endothelial cells.	INS INS-IGF2	4.11e-06	2	71	2	12059784
Pubmed	Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function.	INS INS-IGF2	4.11e-06	2	71	2	19801494
Pubmed	Increasing hepatic glycogen moderates the diabetic phenotype in insulin-deficient Akita mice.	INS INS-IGF2	4.11e-06	2	71	2	33667544
Pubmed	Tissue- and developmental stage-specific imprinting of the mouse proinsulin gene, Ins2.	INS INS-IGF2	4.11e-06	2	71	2	7729600
Pubmed	Genetic modulation of diabetic nephropathy among mouse strains with Ins2 Akita mutation.	INS INS-IGF2	4.11e-06	2	71	2	25428948
Pubmed	Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response.	INS INS-IGF2	4.11e-06	2	71	2	26595448
Pubmed	Tyrosine nitration of prostacyclin synthase is associated with enhanced retinal cell apoptosis in diabetes.	INS INS-IGF2	4.11e-06	2	71	2	22015457
Pubmed	Altered Gut Microbiota Activate and Expand Insulin B15-23-Reactive CD8+ T Cells.	INS INS-IGF2	4.11e-06	2	71	2	30796028
Pubmed	Impact of genetic background on nephropathy in diabetic mice.	INS INS-IGF2	4.11e-06	2	71	2	16118394
Pubmed	High glucose and diabetes modulate cellular proteasome function: Implications in the pathogenesis of diabetes complications.	INS INS-IGF2	4.11e-06	2	71	2	23391566
Pubmed	Reduced Circulating Insulin Enhances Insulin Sensitivity in Old Mice and Extends Lifespan.	INS INS-IGF2	4.11e-06	2	71	2	28700945
Pubmed	Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic β cells.	INS INS-IGF2	4.11e-06	2	71	2	23275337
Pubmed	Novel diabetic mouse models as tools for investigating diabetic retinopathy.	INS INS-IGF2	4.11e-06	2	71	2	23251343
Pubmed	The altered renal and hepatic expression of solute carrier transporters (SLCs) in type 1 diabetic mice.	INS INS-IGF2	4.11e-06	2	71	2	25789863
Pubmed	A sensitized screen of N-ethyl-N-nitrosourea-mutagenized mice identifies dominant mutants predisposed to diabetic nephropathy.	INS INS-IGF2	4.11e-06	2	71	2	17151334
Pubmed	Inhibition of plasminogen activator inhibitor-1 restores skeletal muscle regeneration in untreated type 1 diabetic mice.	INS INS-IGF2	4.11e-06	2	71	2	21593201
Pubmed	Dynamic Ins2 Gene Activity Defines β-Cell Maturity States.	INS INS-IGF2	4.11e-06	2	71	2	36170671
Pubmed	Proinsulin maturation disorder is a contributor to the defect of subsequent conversion to insulin in β-cells.	INS INS-IGF2	4.11e-06	2	71	2	21723250
Pubmed	Pharmacological Inhibition of Inositol-Requiring Enzyme 1α RNase Activity Protects Pancreatic Beta Cell and Improves Diabetic Condition in Insulin Mutation-Induced Diabetes.	INS INS-IGF2	4.11e-06	2	71	2	34675883
Pubmed	The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic beta cells.	INS INS-IGF2	4.11e-06	2	71	2	15005713
Pubmed	Does rosiglitazone affect adiposity and cardiac function in genetic diabetic mice?	INS INS-IGF2	4.11e-06	2	71	2	23228931
Pubmed	Protection against type 1 diabetes upon Coxsackievirus B4 infection and iNKT-cell stimulation: role of suppressive macrophages.	INS INS-IGF2	4.11e-06	2	71	2	23894189
Pubmed	Metabolic effects of short-term caloric restriction in mice with reduced insulin gene dosage.	INS INS-IGF2	4.11e-06	2	71	2	29439088
Pubmed	Hyperglycemia and xerostomia are key determinants of tooth decay in type 1 diabetic mice.	INS INS-IGF2	4.11e-06	2	71	2	22449801
Pubmed	Insulin2 gene (Ins2) transcription by NOD bone marrow-derived cells does not influence autoimmune diabetes development in NOD-Ins2 knockout mice.	INS INS-IGF2	4.11e-06	2	71	2	19874548
Pubmed	The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy.	INS INS-IGF2	4.11e-06	2	71	2	29434227
Pubmed	Determining the role of SGLT2 inhibition with Empagliflozin in the development of diabetic retinopathy.	INS INS-IGF2	4.11e-06	2	71	2	35234250
Pubmed	Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes.	INS INS-IGF2	4.11e-06	2	71	2	16936198
Pubmed	Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice.	INS INS-IGF2	4.11e-06	2	71	2	19542201
Pubmed	Antagonising Wnt/β-catenin signalling ameliorates lens-capsulotomy-induced retinal degeneration in a mouse model of diabetes.	INS INS-IGF2	4.11e-06	2	71	2	30019207
Pubmed	Glucolipotoxicity diminishes cardiomyocyte TFEB and inhibits lysosomal autophagy during obesity and diabetes.	INS INS-IGF2	4.11e-06	2	71	2	27620487
Pubmed	Heterogeneous Nuclear Ribonucleoprotein F Mediates Insulin Inhibition of Bcl2-Modifying Factor Expression and Tubulopathy in Diabetic Kidney.	INS INS-IGF2	4.11e-06	2	71	2	31040360
Pubmed	Imprinting at the mouse Ins2 locus: evidence for cis- and trans-allelic interactions.	INS INS-IGF2	4.11e-06	2	71	2	9465295
Pubmed	The selective recruitment of mRNA to the ER and an increase in initiation are important for glucose-stimulated proinsulin synthesis in pancreatic beta-cells.	INS INS-IGF2	4.11e-06	2	71	2	15972000
Pubmed	Circulating sphingolipid biomarkers in models of type 1 diabetes.	INS INS-IGF2	4.11e-06	2	71	2	21068007
Pubmed	Cardiac transcriptome profiling of diabetic Akita mice using microarray and next generation sequencing.	INS INS-IGF2	4.11e-06	2	71	2	28837672
Pubmed	Inducing Specific Immune Tolerance to Prevent Type 1 Diabetes in NOD Mice.	INS INS-IGF2	4.11e-06	2	71	2	26784909
Pubmed	Novel splice variant of mouse insulin2 mRNA: implications for insulin expression.	INS INS-IGF2	4.11e-06	2	71	2	20153322
Pubmed	Noninvasive temporal detection of early retinal vascular changes during diabetes.	INS INS-IGF2	4.11e-06	2	71	2	33060607
Pubmed	Transgenic Expression of miR-133a in the Diabetic Akita Heart Prevents Cardiac Remodeling and Cardiomyopathy.	INS INS-IGF2	4.11e-06	2	71	2	31069235
Pubmed	High fat diet induces brain insulin resistance and cognitive impairment in mice.	INS INS-IGF2	4.11e-06	2	71	2	27771511
Pubmed	Activation of endothelial NAD(P)H oxidase accelerates early glomerular injury in diabetic mice.	INS INS-IGF2	4.11e-06	2	71	2	26552047
Pubmed	Reduced ocular blood flow as an early indicator of diabetic retinopathy in a mouse model of diabetes.	INS INS-IGF2	4.11e-06	2	71	2	22915034
Pubmed	Predisposition to Proinsulin Misfolding as a Genetic Risk to Diet-Induced Diabetes.	INS INS-IGF2	4.11e-06	2	71	2	34462258
Pubmed	Prevention of diabetic nephropathy in Ins2(+/)⁻(AkitaJ) mice by the mitochondria-targeted therapy MitoQ.	INS INS-IGF2	4.11e-06	2	71	2	20825366
Pubmed	Misfolded proinsulin affects bystander proinsulin in neonatal diabetes.	INS INS-IGF2	4.11e-06	2	71	2	19880509
Pubmed	Register shifting of an insulin peptide-MHC complex allows diabetogenic T cells to escape thymic deletion.	INS INS-IGF2	4.11e-06	2	71	2	22065673
Pubmed	Increased superoxide contributes to enhancement of vascular contraction in Ins2(Akita) diabetic mice, an autosomal dominant mutant model.	INS INS-IGF2	4.11e-06	2	71	2	18788099
Pubmed	Insulin as a T cell antigen in type 1 diabetes supported by the evidence from the insulin knockout NOD mice.	INS INS-IGF2	4.11e-06	2	71	2	17459508
Pubmed	Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice.	INS INS-IGF2	4.11e-06	2	71	2	15889095
Pubmed	Interaction of glucagon-like peptide-I (7-37) and somatostatin-14 on signal transduction and proinsulin gene expression in beta TC-1 cells.	INS INS-IGF2	4.11e-06	2	71	2	7911222
Pubmed	GYY4137, a Hydrogen Sulfide Donor Modulates miR194-Dependent Collagen Realignment in Diabetic Kidney.	INS INS-IGF2	4.11e-06	2	71	2	28883608
Pubmed	Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse.	INS INS-IGF2	4.11e-06	2	71	2	12540615
Pubmed	Different mechanisms are used by insulin to repress three genes that contain a homologous thymine-rich insulin response element.	INS INS-IGF2	4.11e-06	2	71	2	12914928
Pubmed	Complications of IgA nephropathy in a non-insulin-dependent diabetes model, the Akita mouse.	INS INS-IGF2	4.11e-06	2	71	2	12630555
Pubmed	Retinal blood flow abnormalities following six months of hyperglycemia in the Ins2(Akita) mouse.	INS INS-IGF2	4.11e-06	2	71	2	22440813
Pubmed	Dual inhibition of SGLT2 and DPP-4 promotes natriuresis and improves glomerular hemodynamic abnormalities in KK/Ta-Ins2Akita mice with progressive diabetic kidney disease.	INS INS-IGF2	4.11e-06	2	71	2	36265286
Pubmed	Dominant protein interactions that influence the pathogenesis of conformational diseases.	INS INS-IGF2	4.11e-06	2	71	2	23722904
Interaction	TCTN2 interactions	CNNM1 LRP12 RPN2 JMJD8 TMEM43 DNAJC1 BACE2 MFSD10 TCTN2	9.21e-07	304	69	9	int:TCTN2
Interaction	BRICD5 interactions	CNNM1 LRP12 LRRC25 TNFSF9 LRP11 PSCA NMU	4.48e-06	194	69	7	int:BRICD5
Interaction	DIPK1A interactions	CNNM1 LRP12 SUSD1 PSCA TCTN2	1.50e-05	91	69	5	int:DIPK1A
Interaction	HLA-C interactions	CNNM1 TNFSF9 RPN2 INS PSCA DNAJC1 NMU TCTN2	2.70e-05	353	69	8	int:HLA-C
Interaction	TMEM59 interactions	LRP12 TNFSF9 ADAM9 PCDHA8 TMEM43 NMU	3.62e-05	181	69	6	int:TMEM59
Interaction	ADAMTS2 interactions	ADAMTS4 INS PSCA TCTN2	4.04e-05	56	69	4	int:ADAMTS2
Interaction	WNT5A interactions	FZD1 WNT16 PSCA TCTN2	9.20e-05	69	69	4	int:WNT5A
Interaction	RNF149 interactions	CNNM1 GINM1 RPN2 UNC5B PCDHA8 TMEM43 DNAJC1 PTTG1IP ALG1	1.02e-04	549	69	9	int:RNF149
Cytoband	Ensembl 112 genes in cytogenetic band chr6q25	FNDC1 GINM1 LRP11 ULBP2	1.27e-04	164	71	4	chr6q25
Cytoband	6q25	FNDC1 ULBP2	1.54e-04	12	71	2	6q25
Cytoband	2p12	IGKV1-39 IGKV1-8 IGKV1D-39	8.13e-04	117	71	3	2p12
Cytoband	6q25.1	GINM1 LRP11	1.60e-03	38	71	2	6q25.1
GeneFamily	Low density lipoprotein receptors	LRP12 LRP11	6.20e-04	13	52	2	634
GeneFamily	Solute carriers	SLC6A13 SLC45A3 SLC28A1 SLC9A7 MTCH2 SLC22A31	9.12e-04	395	52	6	752
GeneFamily	Immunoglobulin kappa locus at 2p11.2	IGKV1-39 IGKV1-8 IGKV1D-39	1.75e-03	83	52	3	351
GeneFamily	Glycosyltransferase family 6\|Blood group antigens	SEMA7A CD55	5.07e-03	37	52	2	454
Coexpression	NABA_MATRISOME	ZP1 SERPINA11 FNDC1 FLT3LG IGFALS SCUBE2 SEMA7A ADAMTS4 TNFSF9 MMP28 INS ADAM9 WNT16 EFEMP2 NID1 CBLN1 INS-IGF2 FBN3	1.76e-10	1026	71	18	M5889
Coexpression	NABA_MATRISOME	ZP1 SERPINA11 FNDC1 FLT3LG IGFALS SCUBE2 SEMA7A ADAMTS4 TNFSF9 MMP28 INS ADAM9 WNT16 EFEMP2 NID1 CBLN1 INS-IGF2	1.13e-09	1008	71	17	MM17056
Coexpression	NABA_MATRISOME_ASSOCIATED	SERPINA11 FLT3LG SCUBE2 SEMA7A ADAMTS4 TNFSF9 MMP28 INS ADAM9 WNT16 CBLN1 INS-IGF2	6.35e-07	738	71	12	MM17058
Coexpression	NABA_MATRISOME_ASSOCIATED	SERPINA11 FLT3LG SCUBE2 SEMA7A ADAMTS4 TNFSF9 MMP28 INS ADAM9 WNT16 CBLN1 INS-IGF2	7.63e-07	751	71	12	M5885
Coexpression	NABA_ECM_GLYCOPROTEINS	ZP1 FNDC1 IGFALS EFEMP2 NID1 FBN3	1.55e-05	196	71	6	M3008
Coexpression	MILI_PSEUDOPODIA_CHEMOTAXIS_DN	LRP12 TNFSF9 RPN2 TMEM43 MTCH2 MFSD10 ALG1 ABCC10	3.27e-05	457	71	8	M1613
Coexpression	NABA_SECRETED_FACTORS	FLT3LG SCUBE2 TNFSF9 INS WNT16 CBLN1 INS-IGF2	3.65e-05	338	71	7	MM17064
Coexpression	MILI_PSEUDOPODIA_CHEMOTAXIS_DN	LRP12 TNFSF9 RPN2 TMEM43 MTCH2 MFSD10 ALG1 ABCC10	3.99e-05	470	71	8	MM1053
Coexpression	NABA_SECRETED_FACTORS	FLT3LG SCUBE2 TNFSF9 INS WNT16 CBLN1 INS-IGF2	4.01e-05	343	71	7	M5883
Coexpression	NABA_MATRISOME_METASTATIC_COLORECTAL_LIVER_METASTASIS	FNDC1 IGFALS EFEMP2	7.34e-05	30	71	3	M47990
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_DN	LRP12 TNFSF9 TM9SF3 TMEM115 NID1 TMEM43 DNAJC1 PTTG1IP MFSD10	9.06e-05	681	71	9	M5314
Coexpression	AKT_UP.V1_UP	PTPRJ UNC5B PSCA CD55 BACE2	9.70e-05	169	71	5	M2669
Coexpression	NABA_CORE_MATRISOME	ZP1 FNDC1 IGFALS EFEMP2 NID1 FBN3	1.02e-04	275	71	6	M5884
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_DN	LRP12 TNFSF9 TM9SF3 TMEM115 NID1 TMEM43 DNAJC1 PTTG1IP MFSD10	1.15e-04	703	71	9	MM1055
Coexpression	CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3	CDH26 PTPRJ SUSD1 LRP11 TM9SF3 CD55 IL20RA BACE2 ALG1	1.47e-04	726	71	9	M4210
Coexpression	WANG_SMARCE1_TARGETS_UP	FZD1 FNDC1 UNC5B CD55 NID1 BACE2	1.47e-04	294	71	6	M1804
Coexpression	GAO_LARGE_INTESTINE_24W_C1_DCLK1POS_PROGENITOR	FZD1 FNDC1 SCUBE2 ADAMTS4	1.53e-04	99	71	4	M39152
Coexpression	NABA_ECM_GLYCOPROTEINS	ZP1 FNDC1 IGFALS EFEMP2 NID1	1.72e-04	191	71	5	MM17059
Coexpression	BENPORATH_ES_WITH_H3K27ME3	FZD1 CNNM1 FNDC1 GPR150 TNFSF9 GPR62 UNC5B WNT16 SIDT1 ULBP2 CBLN1	1.93e-04	1115	71	11	M10371
Coexpression	GSE43863_NAIVE_VS_MEMORY_LY6C_INT_CXCR5POS_CD4_TCELL_D150_LCMV_UP	SIAE PTPRCAP PTPRJ SUSD1 KDM2A	2.13e-04	200	71	5	M9739
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SCUBE2 MMP28 LRP11 SIDT1 PSCA CD55 IL20RA	2.53e-08	193	71	7	a5695ce2e24a62026ae28f3dea07ca4a435206b8
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-B\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGKV1-39 IGKV1-8 PTPRCAP SEMA7A WNT16 IGKV1D-39	7.38e-07	197	71	6	88b29d205237f07a9a26cc15a1cf4ed4816a4c4b
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-B-B_cell-B_naive\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGKV1-39 IGKV1-8 PTPRCAP WNT16 SLC9A7 IGKV1D-39	7.60e-07	198	71	6	79c690d21d3420d0bb1a3b3b4ea2c9aa3810a219
ToppCell	droplet-Lung-immune-endo-depleted-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRCAP LRP11 WNT16 CD55 UTF1	6.68e-06	165	71	5	22293c6b55f44636440cd737efb786ff5de3373d
ToppCell	wk_15-18-Hematologic_Lymphocytic-B-CD5+_CCL22+_mature_B\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	IGKV1-39 PTPRCAP SEMA7A SLC9A7 IGKV1D-39	8.89e-06	175	71	5	fa53ea81ad943a2cd266114829135cbcbcf2f634
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6\|TCGA-Ovary / Sample_Type by Project: Shred V9	FZD1 FNDC1 SEMA7A ADAMTS4 NID1	9.66e-06	178	71	5	142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCell	wk_20-22-Hematologic-Myeloid-pDC\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	ZP1 SEMA7A SUSD1 TNFSF9 SIDT1	1.05e-05	181	71	5	60607c5ff6d5b1cb416adc034491dca31c41e988
ToppCell	Globus_pallidus-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Ttyh1_(Ttyh1)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	IGFALS SLC45A3 SLC28A1 UTF1	1.10e-05	86	71	4	c7d17025bad7bb57f034064ff2c9d9919509ef9a
ToppCell	Globus_pallidus-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Ttyh1_(Ttyh1)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	IGFALS SLC45A3 SLC28A1 UTF1	1.10e-05	86	71	4	95fea8fc55c9f321ef9285f05dc144a5f817f2da
ToppCell	facs-Liver-Hepatocytes-24m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SERPINA11 SLC6A13 IGFALS SLC45A3 ADAM9	1.10e-05	183	71	5	d0721c6aa426953a520d40e976b6e65aa7ca65e8
ToppCell	Mild-Lymphoid-B\|Mild / Condition, Lineage, Cell class and cell subclass	IGKV1-39 IGKV1-8 PTPRCAP SEMA7A IGKV1D-39	1.10e-05	183	71	5	9b64d2d143525e6f48a191facfd101462ff36324
ToppCell	Mild_COVID-19-B_cell\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	IGKV1-39 IGKV1-8 PTPRCAP SEMA7A IGKV1D-39	1.10e-05	183	71	5	dea119e2988e954475f557f0bbe12556a83e81a4
ToppCell	Mild-Lymphoid-B-\|Mild / Condition, Lineage, Cell class and cell subclass	IGKV1-39 IGKV1-8 PTPRCAP SEMA7A IGKV1D-39	1.10e-05	183	71	5	b5740f05a4dcdbbf24f7bf7a3f57ac01a5e75f60
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-10\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGKV1-39 SEMA7A TNFSF9 WNT16 BACE2	1.10e-05	183	71	5	01664fce6b70a02c9d39d747b6a6aabc86d57bc2
ToppCell	5'-GW_trimst-2-LymphNode-Hematopoietic-B_cells-Immature_B\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGKV1-39 IGKV1-8 PTPRCAP SLC9A7 IGKV1D-39	1.19e-05	186	71	5	459a7e97bbac2b2cd253aa4ab38d0e4ae6191e8b
ToppCell	Mild_COVID-19-B_cell-B_cell\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	IGKV1-39 IGKV1-8 PTPRCAP SEMA7A IGKV1D-39	1.19e-05	186	71	5	855a5a00ba2aa1b5c63b8db56d026ddecc546050
ToppCell	15-Trachea-Epithelial-Secretory_progenitor\|Trachea / Age, Tissue, Lineage and Cell class	IGFALS SCUBE2 EFEMP2 CD55 FBN3	1.23e-05	187	71	5	be9fce9e74b2f170a2067f1b31d802912a578329
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FNDC1 PTPRJ TNFSF9 CD55 NID1	1.26e-05	188	71	5	aa516273cdde53c8c0295f06830972388f890c97
ToppCell	10x5'-Liver-Lymphocytic_B\|Liver / Manually curated celltypes from each tissue	IGKV1-39 SLC45A3 WNT16 SLC9A7 BACE2	1.29e-05	189	71	5	1ebff8185060d78f27f8d887e9adaa5f8faf2196
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-lymphocytic-B_lymphocytic-plasma_cell\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	IGKV1-39 IGKV1-8 PRSS16 DNAJC1 IGKV1D-39	1.29e-05	189	71	5	5a42be62552d912d0abf68f00d75ac80bbd69f2c
ToppCell	wk_15-18-Hematologic_Lymphocytic-B-CD5-_Mature_B\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	IGKV1-39 PTPRCAP SIDT1 CD55 IGKV1D-39	1.32e-05	190	71	5	ade43d1d1f8909b8526a23152acf3c26f160f836
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic-plasma_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	IGKV1-39 PRSS16 RPN2 DNAJC1 IGKV1D-39	1.32e-05	190	71	5	76b747bafff09bf8375a5717c9f213cbfb405bac
ToppCell	COVID-19_Severe-Lymphoid_B-B_intermediate\|COVID-19_Severe / Disease group, lineage and cell class	SEMA7A TNFSF9 WNT16 SLC9A7 BACE2	1.43e-05	193	71	5	ea079e6f7242a2bbc8260299ad9e9bdabb9856f8
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-DC3-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SEMA7A SUSD1 TNFSF9 SIDT1 CD55	1.43e-05	193	71	5	30abf991ac17c18679ab7d633e7549c0ce841920
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SEMA7A TNFSF9 WNT16 SLC9A7 BACE2	1.43e-05	193	71	5	b5e44fe60dc84dc050d4fa3ccec4e257e51dc636
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_intermediate\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SEMA7A TNFSF9 WNT16 SLC9A7 BACE2	1.43e-05	193	71	5	e2cf2f4f142e1b4dda3ded28b5208eef3f301a43
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_intermediate\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SEMA7A TNFSF9 WNT16 SLC9A7 BACE2	1.46e-05	194	71	5	7f62bd52779e2779447b23bdd330be4b5b35910a
ToppCell	droplet-Bladder-Unstain-18m-Epithelial-bladder_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD1 ADAMTS4 TNFSF9 EFEMP2 NID1	1.46e-05	194	71	5	ee6b5fb4e993a4c0dc556091b8fefd56bdc70d8f
ToppCell	droplet-Bladder-Unstain-18m-Epithelial-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD1 ADAMTS4 TNFSF9 EFEMP2 NID1	1.50e-05	195	71	5	841fde528ecb293e07b5e00e499d1e9f0b0dce14
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGFALS INS LRP11 PCDHA8 BACE2	1.50e-05	195	71	5	bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCell	Goblet_1\|World / shred by cell class for nasal brushing	ADAM9 TM9SF3 PSCA CD55 PTTG1IP	1.50e-05	195	71	5	d9e4889a2e7b7c97c07c15b043b77837739462e4
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-B\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGKV1-39 IGKV1-8 PTPRCAP WNT16 IGKV1D-39	1.58e-05	197	71	5	9fe1b757f76c2d43d39aa9ac500eaba98723985c
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-B-B_intermediate\|COVID-19_Severe / Disease, condition lineage and cell class	SEMA7A TNFSF9 WNT16 SLC9A7 BACE2	1.65e-05	199	71	5	ad3c369a67926725917b771094f82ca6dd2af783
ToppCell	PND07-28-samps-Lymphocyte-T_cells-T_cells_2\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	SLC6A13 FLT3LG PTPRCAP PRSS16	7.02e-05	138	71	4	221a964e86d7d3406cdb7573899155fee8d33abd
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INS CD55 IL20RA NID1	1.10e-04	155	71	4	8fdda4e3657ac56188ae88ed3caf145f4d9d1567
ToppCell	343B-Myeloid-Dendritic-pDC\|343B / Donor, Lineage, Cell class and subclass (all cells)	SEMA7A SUSD1 TNFSF9 SIDT1	1.13e-04	156	71	4	547e2debfc09c07c049a880dded5fda7dd53e156
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLT3LG PTPRCAP PRSS16 PSCA	1.13e-04	156	71	4	33deda19f06172079ef1dd49fd54d66da1e7fb14
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma-5\|TCGA-Colorectal / Sample_Type by Project: Shred V9	IGFALS PRSS16 SIDT1 CD55	1.16e-04	157	71	4	5fb41af247465aa29aa7b8edd26e3d3794766f80
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-NK_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRCAP PRSS16 SIDT1 UTF1	1.18e-04	158	71	4	8844fba9c1e41f062edf3110d025f33b86afb951
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-Natural_Killer\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRCAP PRSS16 SIDT1 UTF1	1.18e-04	158	71	4	c56607cba9a3719ac6d573d970686053e1676985
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Cbln1-Excitatory_Neuron.Slc17a7.Reln_(Medial_entorrhinal_cortexm,_Reln+/Cbln1+)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PRSS16 SLC28A1 CBLN1	1.27e-04	61	71	3	5e855b5462f42b7a1d0bbd518cc11072342ce0cc
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Cbln1-Excitatory_Neuron.Slc17a7.Reln_(Medial_entorrhinal_cortexm,_Reln+/Cbln1+)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PRSS16 SLC28A1 CBLN1	1.27e-04	61	71	3	2fc13475581431f82e0b5ef42e18cd29c9787666
ToppCell	droplet-Thymus-nan-21m-Myeloid-Macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD1 FNDC1 LRRC25 MMP28	1.27e-04	161	71	4	441ebd3c029861d833fbcf8a68fc740d9de8ef2f
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGKV1-8 PTPRCAP SEMA7A TNFSF9	1.30e-04	162	71	4	b46158e260bd2f35702cec73e3b035e8e9ec4469
ToppCell	facs-Heart-LV-24m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGFALS SCUBE2 INS PSCA	1.34e-04	163	71	4	648d5439811b64412bc4678646f216105b90b9a1
ToppCell	facs-Trachea-18m-Hematologic-lymphocytic-B_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PTPRCAP PRSS16 INS KDM2A	1.37e-04	164	71	4	4274a4f225cabf61f0fe27d8ea162b4eba612f87
ToppCell	facs-Trachea-18m-Hematologic-lymphocytic-B_cell-B_cell_of_the_trachea\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PTPRCAP PRSS16 INS KDM2A	1.37e-04	164	71	4	d62143450f59097ad4b34603a6257f897a769ead
ToppCell	droplet-Fat-SCAT-30m-Lymphocytic-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZP1 SLC6A13 PTPRCAP ADAMTS4	1.43e-04	166	71	4	67370c49d7aedcb4eca802095f06b30f6bbf8919
ToppCell	droplet-Lung-nan-18m-Lymphocytic-Zbtb32+_B\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRCAP SUSD1 WNT16 CD55	1.43e-04	166	71	4	3e3e9296e6919a38602e417a6606c046af3bd101
ToppCell	droplet-Fat-SCAT-30m-Lymphocytic\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZP1 SLC6A13 PTPRCAP ADAMTS4	1.43e-04	166	71	4	7f4e5976ede6478636aa567d6fc2b56ff7295fb8
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Pde1a_(dSPN)-\|Striatum / BrainAtlas - Mouse McCarroll V32	SERPINA11 INS NMU	1.46e-04	64	71	3	def8cf047ec3ba3c40bb759d0910838df857f05b
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Pde1a_(dSPN)\|Striatum / BrainAtlas - Mouse McCarroll V32	SERPINA11 INS NMU	1.46e-04	64	71	3	cec968dc404934fa9888d445d7c4cd2df7f3cc7a
ToppCell	367C-Myeloid-Dendritic-pDC\|367C / Donor, Lineage, Cell class and subclass (all cells)	SEMA7A SUSD1 SIDT1 SLC9A7	1.47e-04	167	71	4	650de8cd5df070639b8aa292aacead739cfdb02c
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-Zbtb32+_B_cell-Zbtb32+_B_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PTPRCAP SUSD1 WNT16 CD55	1.47e-04	167	71	4	3c3e1c31aacca48099693aea2efdfa22fc0e4af4
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-Zbtb32+_B_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PTPRCAP SUSD1 WNT16 CD55	1.47e-04	167	71	4	77a4d7ce44847c76074d4f5340d61b398fe43e6c
ToppCell	10x5'-GI_large-bowel\|World / Manually curated celltypes from each tissue	IGKV1-39 IGKV1-8 PTPRCAP IGKV1D-39	1.50e-04	168	71	4	1290c909655bc37f6b8bf216d18127a21b99e9c0
ToppCell	BAL-Mild-Lymphocyte-B\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGKV1-39 IGKV1-8 WNT16 IGKV1D-39	1.53e-04	169	71	4	307571e57c3bfdf15f0fe1a8b36585e8e4f8a207
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)-Goblet_(bronchial)_L.0.4.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SERPINA11 CYP21A2 SLC28A1 BACE2	1.53e-04	169	71	4	db73dae011ff3749b3706e50ab46d03b775dd6bb
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SERPINA11 CYP21A2 SLC28A1 BACE2	1.53e-04	169	71	4	97b7047b87ce0052d8580565c9b44fd2aa6f0d5c
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SERPINA11 CYP21A2 SLC28A1 BACE2	1.53e-04	169	71	4	1a684471dbda42e1470e5a889648666e14f25982
ToppCell	BAL-Mild-Lymphocyte-B-B_cell-B_cell-B_activate-7\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGKV1-39 IGKV1-8 WNT16 IGKV1D-39	1.57e-04	170	71	4	ee2ee67d90ae4596de8ccd620e37c82cf51651d4
ToppCell	BAL-Mild-Lymphocyte-B-B_cell-B_cell\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGKV1-39 IGKV1-8 WNT16 IGKV1D-39	1.57e-04	170	71	4	d7ca0c6ce5d2b7de99346f87e07aa7fe728fa08a
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPRCAP SEMA7A SUSD1 TNFSF9	1.57e-04	170	71	4	92e765ae0d3adb38d3b22fddb873fd5ccad3fd44
ToppCell	BAL-Mild-Lymphocyte-B-B_cell\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGKV1-39 IGKV1-8 WNT16 IGKV1D-39	1.57e-04	170	71	4	52787f6d529c285d9f0c04cc022710ead5b89b3f
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPRCAP SEMA7A SUSD1 TNFSF9	1.57e-04	170	71	4	9f8b215caa1afa3cd7104c06fca7cfd790640f66
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell-Papillary_Tip_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SCUBE2 MMP28 PSCA CD55	1.60e-04	171	71	4	59b9dbaa05b6e5740edc633c9ce1181565550d5b
ToppCell	Myeloid-Myeloid-D_(Mast_cell)\|Myeloid / shred on cell class and cell subclass (v4)	PTPRCAP SUSD1 SLC45A3 CD55	1.60e-04	171	71	4	5f1aafc4c55a9c6c3153430186a8a351425a3cb9
ToppCell	mild-Myeloid-Eosinophils\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	SEMA7A SLC45A3 WNT16 BACE2	1.60e-04	171	71	4	5c8198182495bda7a826e9d80aa467f4eb1094ec
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SCUBE2 MMP28 PSCA CD55	1.60e-04	171	71	4	a5b9dd2b6a54db7962beeb5a9ceb9dacfb613fa7
ToppCell	wk_08-11-Hematologic_Lymphocytic-B\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	IGKV1-39 IGKV1-8 PTPRCAP IGKV1D-39	1.64e-04	172	71	4	d1ab8f493b70ec995281f9fb0991f1d3aa7b928f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRJ SUSD1 BACE2 FBN3	1.72e-04	174	71	4	5f4436863a40f8bca46e2989bca66c02b6be88d4
ToppCell	TCGA-Colorectal-Recurrent_Tumor\|TCGA-Colorectal / Sample_Type by Project: Shred V9	SERPINA11 CYP21A2 SLC28A1 INS-IGF2	1.75e-04	175	71	4	7f74961436f88c0e380819095e6104489914d765
ToppCell	TCGA-Colorectal-Recurrent_Tumor-Colorectal_Adenocarcinoma\|TCGA-Colorectal / Sample_Type by Project: Shred V9	SERPINA11 CYP21A2 SLC28A1 INS-IGF2	1.75e-04	175	71	4	bee8f31f036dfcf9fc6ed29156554771a9ee3c60
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-T_cells-NK_T_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LRRC25 PTPRCAP SEMA7A SIDT1	1.79e-04	176	71	4	1ea45cf7b7e12206c3eca1594173368643c50e59
ToppCell	droplet-Fat-SCAT-30m-Lymphocytic-T_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZP1 SLC6A13 PTPRCAP ADAMTS4	1.83e-04	177	71	4	baf78a8dad55f124f56585f88b10b58c0269680f
ToppCell	droplet-Lung-1m-Hematologic-lymphocytic-Zbtb32+_B_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PTPRCAP WNT16 CD55 UTF1	1.83e-04	177	71	4	a58c93be9767e3fe8fbb6b0db1210d3a33aac662
ToppCell	droplet-Lung-1m-Hematologic-lymphocytic-Zbtb32+_B_cell-Zbtb32+_B_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PTPRCAP WNT16 CD55 UTF1	1.83e-04	177	71	4	3ed383e5c0b15d9d5e75b98cf6d10609f48fc422
ToppCell	(06)_Krt4/13+\|World / shred by cell type and Timepoint	UNC5B PSCA TMEM43 BACE2	1.87e-04	178	71	4	46efdf03aa1317bc600138e871509b995e773cce
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-7\|TCGA-Colorectal / Sample_Type by Project: Shred V9	FNDC1 LRP11 NID1 KDM2A	1.87e-04	178	71	4	edc76b8f15056ec1c9a1c61a048b6331a92592d6
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGKV1-39 IGKV1-8 PTPRCAP IGKV1D-39	1.87e-04	178	71	4	107dae8b00c4257697a63700e72bb434cdb8406f
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-Zbtb32+_B\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRCAP GPR150 WNT16 CD55	1.87e-04	178	71	4	9b932b677ae05ac6e12cd6ce97789f8c10e4790b
ToppCell	facs-Kidney-nan-18m-Lymphocytic-B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRCAP SUSD1 CD55 SLC9A7	1.91e-04	179	71	4	f4fd214a9865c635d8a744ce5e0eff45174d3de4
ToppCell	facs-Kidney-nan-18m-Lymphocytic-B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRCAP SUSD1 CD55 SLC9A7	1.91e-04	179	71	4	57d8d44a793314eec8f77030f4177bfe21d41652
ToppCell	moderate-Myeloid-pDC\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	PTPRCAP SEMA7A SUSD1 SIDT1	1.95e-04	180	71	4	1d8df7df03a71f49d6683554d3c948ce90dda42e
ToppCell	facs-Bladder-nan-24m-Epithelial-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC1 ADAMTS4 TNFSF9 EFEMP2	1.95e-04	180	71	4	12537d8a569faa69f474284d2c201475722b8ca1
ToppCell	BAL-Mild-Lymphocyte-B\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	IGKV1-39 IGKV1-8 SEMA7A IGKV1D-39	1.99e-04	181	71	4	700adfb41e4e377530f0dd31be89e12f109f3469
ToppCell	Smart-seq2-blood_(Smart-seq2)-lymphocytic-B_lymphocytic-memory_B_cell\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	IGKV1-39 TNFSF9 WNT16 IGKV1D-39	1.99e-04	181	71	4	768d14c452192f92fa557ae59e84c43436f575f0
ToppCell	10x5'-Liver-Lymphocytic_B-Memory_B_cells\|Liver / Manually curated celltypes from each tissue	SLC45A3 WNT16 IGKV1D-39 BACE2	1.99e-04	181	71	4	a9f4df288c34e3b2b6ed861ac6cda970c3ee08b1
ToppCell	tumor_Lung-Myeloid_cells-pDCs\|tumor_Lung / Location, Cell class and cell subclass	SEMA7A SUSD1 SIDT1 SLC9A7	1.99e-04	181	71	4	c864ffeb9234b8c29754afc91c85a972889617f4
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SCUBE2 SIDT1 PSCA IL20RA	2.04e-04	182	71	4	678eadd57e7e830fc2bf9fd35616d3badce01705
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell-Papillary_Tip_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SCUBE2 SIDT1 PSCA IL20RA	2.04e-04	182	71	4	8d1229fa5aa6e2e38f2ac6fe4f4dc89752fe9344
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CDH26 LRP11 TM9SF3 BACE2	2.04e-04	182	71	4	94e70746e35a3062015d4b83ee545f4f84f47420
ToppCell	Severe_COVID-19-B_cell-B_cell\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	IGKV1-39 IGKV1-8 PTPRCAP SEMA7A	2.08e-04	183	71	4	5634e528001c389efd1e380f01ad40072f60e943
ToppCell	3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGKV1-39 IGKV1-8 DNAJC1 IGKV1D-39	2.08e-04	183	71	4	cf5c98f451a568308c52da5c926543dd4836c6b2
ToppCell	B_cell_maturation-plasma\|World / Lineage and Cell class	IGKV1-39 PRSS16 DNAJC1 IGKV1D-39	2.08e-04	183	71	4	0c3cb61912df05f1beba1004540770ef1a4de786
ToppCell	wk_15-18-Hematologic_Lymphocytic-B-CD5+_CCL22-_mature_B\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	IGKV1-39 PTPRCAP SEMA7A IGKV1D-39	2.12e-04	184	71	4	18aa9c43b79d12c9e420dfd9822745c022be6789
ToppCell	BAL-Mild-Lymphocyte-B-B_cell-B_cell\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	IGKV1-39 IGKV1-8 SEMA7A IGKV1D-39	2.12e-04	184	71	4	3f8a359e40bebe58545f708682e5e5d1b70cf5cb
ToppCell	BAL-Mild-Lymphocyte-B-B_cell-B_cell-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	IGKV1-39 IGKV1-8 SEMA7A IGKV1D-39	2.12e-04	184	71	4	64bede8db709fd32f40c03265b96f0b12155bb8a
ToppCell	Transplant_Alveoli_and_parenchyma-Immune-Mast_cells\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	SEMA7A SLC45A3 RNASE7 BACE2	2.17e-04	185	71	4	a6e5328801c233a44153420e2cdae644b253f540
ToppCell	BAL-Mild-Lymphocyte-B-B_cell\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	IGKV1-39 IGKV1-8 SEMA7A IGKV1D-39	2.17e-04	185	71	4	609080adb2cfb105bb7b8efb617553833299f371
Disease	5-methylthioadenosine (MTA) measurement	GINM1 CYP21A2 LRP11	2.03e-07	6	65	3	EFO_0800130
Disease	X-25420 measurement	SLC6A13 CYP21A2	1.43e-05	3	65	2	EFO_0800926
Disease	beta-aminoisobutyric acid measurement	SLC6A13 SEMA7A FBN3	2.00e-05	24	65	3	EFO_0010464
Disease	1-ribosyl-imidazoleacetate measurement	SLC6A13 CYP21A2	1.70e-04	9	65	2	EFO_0800034
Disease	latent autoimmune diabetes in adults, type 2 diabetes mellitus	INS INS-IGF2	1.70e-04	9	65	2	EFO_0009706, MONDO_0005148
Disease	Alzheimer's disease (biomarker_via_orthology)	INS ADAM9 INS-IGF2	2.89e-04	58	65	3	DOID:10652 (biomarker_via_orthology)
Disease	serum urea measurement	INS CYP21A2 INS-IGF2 ABCC10	9.14e-04	195	65	4	EFO_0009795
Disease	macular telangiectasia type 2	CYP21A2 FBN3	1.50e-03	26	65	2	EFO_1002009
Disease	neutrophil count, basophil count	LRRC25 PTPRJ PCDHA8 PCDHA5	1.52e-03	224	65	4	EFO_0004833, EFO_0005090
Disease	1,5 anhydroglucitol measurement	PCDHA8 PCDHA5	1.87e-03	29	65	2	EFO_0008009

Protein segments in the cluster

Peptide	Gene	Start	Entry
RALLLPLLAQWLLRA	BACE2	6	Q9Y5Z0
LCLLLPLLLLGGWKR	ALG1	11	Q9BT22
ALLLLSWVALGPRSL	IGFALS	11	P35858
LYLARGPLARLLLAW	FBN3	6	Q75N90
GPLARLLLAWSALLC	FBN3	11	Q75N90
LLWLLLLLLAAVAPA	DNAJC1	31	Q96KC8
GLVPRLLGDILSLWL	MTCH2	181	Q9Y6C9
RLLPLLALLALWGPD	INS	6	P01308
RALLLLVPAFLLIGW	MFSD10	341	Q14728
LLAVLGSGLPWLLLL	ABCC10	1056	Q5T3U5
GLRWALPLLLLLLRL	PTPRJ	16	Q12913
RGELGSWRLLLLLLL	PCDHA8	6	Q9Y5H6
VPEARLLGLALAWLR	KLHL34	191	Q8N239
PAQLLGLLLLWLRGA	IGKV1D-39	6	P04432
WALLAFALPALLLLG	GPR62	176	Q9BZJ7
ALRGLLLLCLWLPSG	LRP11	21	Q86VZ4
PRWRSALLLLFLAGV	LRP12	11	Q9Y561
PLLLLLLLLAWCAGA	NMU	21	P48645
LRLLLFVALPASGWL	GINM1	11	Q9NU53
LLGLAIAGPVLAWRL	LRRC25	176	Q8N386
WRLLIFLGLLALPLA	BPIFA3	6	Q9BQP9
LLLLVLLCLPAVWGD	CD55	21	P08174
LLLLPLLAGARLLWN	CYP21A2	6	P08686
LLPVGLLLLAAAWCL	FLT3LG	191	P49771
AWTRALLLPLLLAGP	NID1	11	P14543
RGSLGSRLLLLWLLL	PCDHA5	6	Q9Y5H7
PLLLLLLAAPWGRAV	IL20RA	16	Q9UHF4
LARQLLLLLWLLEAP	FZD1	51	Q9UP38
LLLLWLLEAPLLLGV	FZD1	56	Q9UP38
WLLLLLLASLLPSAR	ADAMTS4	36	O75173
WLVNRLPGLKDLLLA	KDM2A	971	Q9Y2K7
ELLLLGAAWLAGPAR	CBLN1	6	P23435
APRRLSWAALLLLAA	FNDC1	11	Q4ZHG4
GDLGWRLSLLLLPLL	IL27	6	Q8NEV9
TLRVRWLLLLGLVGP	ADAM9	11	Q13443
GRHPSLLLLLVLLLW	CDH26	6	Q8IXH8
QLLGLLLLWLPGARC	IGKV1-8	6	A0A0C4DH67
PAQLLGLLLLWLRGA	IGKV1-39	6	P01597
SCLPGSLLLWALLLL	EFEMP2	6	O95967
AILALLPALGLLLWG	PSCA	96	O43653
LLPGLAALVQDWRLL	SLC22A31	231	A6NKX4
AGFCPLLLLLLLGLW	RNASE7	6	Q9H1E1
LLLLLLLGLWVAEIP	RNASE7	11	Q9H1E1
RNRPGAAWAVLLLLL	SCUBE2	6	Q9NQ36
GALLWVLLLNLGPRA	MENT	6	Q9BUN1
WAPVLLLALGLRGLQ	DPP7	6	Q9UHL4
RLLPLLALLALWGPD	INS-IGF2	6	F8WCM5
GLLLRALQLLLWGHL	MMP28	6	Q9H239
YRPLWALLIAGLALV	TMEM43	371	Q9BTV4
LLLLLLATGLALAWR	PTPRCAP	41	Q14761
ARALAALGWLLALLL	GPR150	161	Q8NGU9
ALGWLLALLLALPPA	GPR150	166	Q8NGU9
LVLGLVLPLILWADR	SIAE	6	Q9HAT2
ILLSLFLIPRAGWLA	SLC45A3	96	Q96JT2
PAWLRALGALLLLAL	CNNM1	221	Q9NRU3
LLLVATLGLGRWLQP	ZP1	16	P60852
SPLLLLFALWIRIGA	RPN2	551	P04844
LRKWGQLLLPSLLDL	SERPINA11	296	Q86U17
RLALLCALPWLLLAA	SIDT1	6	Q9NXL6
WDAGPSRRLLPLLLL	SUSD1	6	Q6UWL2
LGALRWELALCLLLA	SLC6A13	201	Q9NSD5
GRLLEPLWGALELLI	TMEM115	86	Q12893
LVALLALLALALLPW	PRRT4	376	C9JH25
GLPLRLRLLLLLWAA	SEMA7A	26	O75326
LLGLARLCALWAALL	WNT16	6	Q9UBV4
PYWRLRLGGAALLLL	PTTG1IP	11	P53801
LLLALLLCWDPRLSQ	UNC5B	11	Q8IZJ1
VLPWALVAGLLLLLL	TNFSF9	26	P41273
PRLLLWFKRGLALAA	SLC28A1	146	O00337
AAAAALWLLLLLLPR	TM9SF3	11	Q9HD45
LCLPLLLLLSGWSRA	ULBP2	11	Q9BZM5
RLLLLPLLLGWGLRV	SLC9A7	21	Q96T83
SLWGLLAPASLLRRL	PRSS16	16	Q9NQE7
LRLFLLQGILRLLWG	TCTN2	11	Q96GX1
LLGTLLQPAVWRALL	UTF1	71	Q5T230
RLLALWALAAVALPG	JMJD8	6	Q96S16