Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	betaine-homocysteine S-methyltransferase activity	BHMT2 BHMT	8.88e-06	2	60	2	GO:0047150
GeneOntologyMolecularFunction	hexosyltransferase activity	UGT2A1 UGT2A2 A4GNT UGGT2 GBA2	4.28e-04	211	60	5	GO:0016758
GeneOntologyMolecularFunction	S-methyltransferase activity	BHMT2 BHMT	4.80e-04	11	60	2	GO:0008172
GeneOntologyMolecularFunction	transmitter-gated channel activity	CHRNA10 CHRNG GABRR3	9.87e-04	65	60	3	GO:0022835
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity	CHRNA10 CHRNG GABRR3	9.87e-04	65	60	3	GO:0022824
GeneOntologyMolecularFunction	UDP-glycosyltransferase activity	UGT2A1 UGT2A2 A4GNT UGGT2	1.16e-03	153	60	4	GO:0008194
GeneOntologyMolecularFunction	acetylcholine-gated monoatomic cation-selective channel activity	CHRNA10 CHRNG	1.17e-03	17	60	2	GO:0022848
GeneOntologyMolecularFunction	extracellular ligand-gated monoatomic ion channel activity	CHRNA10 CHRNG GABRR3	1.61e-03	77	60	3	GO:0005230
GeneOntologyMolecularFunction	glycosyltransferase activity	UGT2A1 UGT2A2 A4GNT UGGT2 GBA2	1.72e-03	288	60	5	GO:0016757
GeneOntologyMolecularFunction	glucosyltransferase activity	UGGT2 GBA2	1.97e-03	22	60	2	GO:0046527
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	CHRNA10 CNGA4 CHRNG GABRR3	2.70e-03	193	60	4	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	CHRNA10 CNGA4 CHRNG GABRR3	2.91e-03	197	60	4	GO:0022834
GeneOntologyMolecularFunction	gated channel activity	KCNV2 CHRNA10 CNGA4 CHRNG GABRR3	3.27e-03	334	60	5	GO:0022836
GeneOntologyMolecularFunction	neurotransmitter receptor activity	CHRNA10 CHRNG GABRR3	3.39e-03	100	60	3	GO:0030594
GeneOntologyMolecularFunction	hydrolase activity, hydrolyzing O-glycosyl compounds	ACER1 GUSB GBA2	3.69e-03	103	60	3	GO:0004553
MousePheno	abnormal cochlear hair cell physiology	OTOF STRC CHRNA10 STRCP1	1.52e-05	40	53	4	MP:0004432
MousePheno	abnormal hair cell physiology	OTOF STRC CHRNA10 STRCP1	3.44e-05	49	53	4	MP:0003879
Domain	Betaine-hCys_S-MeTrfase_BHMT	BHMT2 BHMT	9.15e-06	2	57	2	IPR017226
Domain	HCY_dom	BHMT2 BHMT	2.74e-05	3	57	2	IPR003726
Domain	-	BHMT2 BHMT	2.74e-05	3	57	2	3.20.20.330
Domain	S-methyl_trans	BHMT2 BHMT	2.74e-05	3	57	2	PF02574
Domain	HCY	BHMT2 BHMT	2.74e-05	3	57	2	PS50970
Domain	Neurotransmitter_ion_chnl_CS	CHRNA10 CHRNG GABRR3	3.49e-04	45	57	3	IPR018000
Domain	Neur_chan_memb	CHRNA10 CHRNG GABRR3	3.73e-04	46	57	3	PF02932
Domain	Neur_chan_LBD	CHRNA10 CHRNG GABRR3	3.97e-04	47	57	3	PF02931
Domain	NEUROTR_ION_CHANNEL	CHRNA10 CHRNG GABRR3	3.97e-04	47	57	3	PS00236
Domain	Neurotrans-gated_channel_TM	CHRNA10 CHRNG GABRR3	3.97e-04	47	57	3	IPR006029
Domain	-	CHRNA10 CHRNG GABRR3	3.97e-04	47	57	3	2.70.170.10
Domain	Neur_channel	CHRNA10 CHRNG GABRR3	3.97e-04	47	57	3	IPR006201
Domain	Neur_chan_lig-bd	CHRNA10 CHRNG GABRR3	3.97e-04	47	57	3	IPR006202
Domain	Nicotinic_acetylcholine_rcpt	CHRNA10 CHRNG	1.07e-03	16	57	2	IPR002394
Domain	-	CHRNA10 CHRNG	2.22e-03	23	57	2	1.20.120.370
Domain	Acetylcholine_rcpt_TM	CHRNA10 CHRNG	2.22e-03	23	57	2	IPR027361
Domain	C2	C2CD3 ITCH OTOF	7.49e-03	131	57	3	PF00168
Domain	C2	C2CD3 ITCH OTOF	8.46e-03	137	57	3	SM00239
Domain	6-blade_b-propeller_TolB-like	LRP5 EIF3B	8.69e-03	46	57	2	IPR011042
Pathway	WP_SPHINGOLIPID_PATHWAY	ACER1 SGPP2 CERS6 GBA2	3.30e-06	30	49	4	M39501
Pathway	REACTOME_SULFUR_AMINO_ACID_METABOLISM	MPST BHMT2 BHMT	7.59e-05	24	49	3	MM14619
Pathway	WP_SPHINGOLIPID_METABOLISM_OVERVIEW	SGPP2 CERS6 GBA2	1.09e-04	27	49	3	M39863
Pathway	REACTOME_SULFUR_AMINO_ACID_METABOLISM	MPST BHMT2 BHMT	1.22e-04	28	49	3	M547
Pathway	REACTOME_SPHINGOLIPID_METABOLISM	ACER1 SGPP2 CERS6 GBA2	2.88e-04	92	49	4	MM15086
Pubmed	118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects.	BHMT2 NOS3 BHMT	1.84e-06	14	61	3	19493349
Pubmed	Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase.	BHMT2 BHMT	3.03e-06	2	61	2	18230605
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	3.03e-06	2	61	2	11687802
Pubmed	Oxidative-mechanical stress signals stem cell niche mediated Lrp5 osteogenesis in eNOS(-/-) null mice.	LRP5 NOS3	3.03e-06	2	61	2	22359381
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	3.03e-06	2	61	2	34910522
Pubmed	The UGT2A1/UGT2A2 locus is associated with COVID-19-related loss of smell or taste.	UGT2A1 UGT2A2	3.03e-06	2	61	2	35039640
Pubmed	Rat olfactory bulb and epithelium UDP-glucuronosyltransferase 2A1 (UGT2A1) expression: in situ mRNA localization and quantitative analysis.	UGT2A1 UGT2A2	3.03e-06	2	61	2	11376859
Pubmed	Human betaine-homocysteine methyltransferase (BHMT) and BHMT2: common gene sequence variation and functional characterization.	BHMT2 BHMT	3.03e-06	2	61	2	18457970
Pubmed	Evolutionary Analyses and Natural Selection of Betaine-Homocysteine S-Methyltransferase (BHMT) and BHMT2 Genes.	BHMT2 BHMT	3.03e-06	2	61	2	26213999
Pubmed	Cloning and characterization of a novel human olfactory UDP-glucuronosyltransferase.	UGT2A1 UGT2A2	3.03e-06	2	61	2	10359671
Pubmed	Betaine-homocysteine methyltransferase-2: cDNA cloning, gene sequence, physical mapping, and expression of the human and mouse genes.	BHMT2 BHMT	3.03e-06	2	61	2	11087663
Pubmed	Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease.	BHMT2 BHMT	3.03e-06	2	61	2	12818402
Pubmed	Integrative predictive model of coronary artery calcification in atherosclerosis.	ADIPOR1 BHMT2 LRP5 PLAT NOS3 BHMT	3.13e-06	229	61	6	19948975
Pubmed	Tissue plasminogen activator is a potent activator of PDGF-CC.	PLAT PDGFC	9.07e-06	3	61	2	15372073
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	9.07e-06	3	61	2	30801007
Pubmed	Obstructive heart defects associated with candidate genes, maternal obesity, and folic acid supplementation.	BHMT2 BHMT	9.07e-06	3	61	2	25846410
Pubmed	tPA regulates neurite outgrowth by phosphorylation of LRP5/6 in neural progenitor cells.	LRP5 PLAT	9.07e-06	3	61	2	23925701
Pubmed	Evidence of interaction between genes in the folate/homocysteine metabolic pathway in controlling risk of non-syndromic oral cleft.	BHMT2 BHMT	9.07e-06	3	61	2	29356306
Pubmed	The Human UDP-glucuronosyltransferase UGT2A1 and UGT2A2 enzymes are highly active in bile acid glucuronidation.	UGT2A1 UGT2A2	9.07e-06	3	61	2	23756265
Pubmed	Human UDP-glucuronosyltransferase UGT2A2: cDNA construction, expression, and functional characterization in comparison with UGT2A1 and UGT2A3.	UGT2A1 UGT2A2	9.07e-06	3	61	2	19858781
Pubmed	New evidence for the role of cystathionine beta-synthase in non-syndromic cleft lip with or without cleft palate.	BHMT2 BHMT	9.07e-06	3	61	2	21564312
Pubmed	Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development.	ACER1 CERS6 GBA2	1.46e-05	27	61	3	23096701
Pubmed	Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.	STRC STRCP1	1.81e-05	4	61	2	18849963
Pubmed	Tissue-type plasminogen activator is not necessary for platelet-derived growth factor-c activation.	PLAT PDGFC	1.81e-05	4	61	2	24269585
Pubmed	Platelet-derived growth factor-C (PDGF-C) activation by serine proteases: implications for breast cancer progression.	PLAT PDGFC	1.81e-05	4	61	2	22035541
Pubmed	Aggravation of focal cerebral ischemia by tissue plasminogen activator is reversed by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor but does not depend on endothelial NO synthase.	PLAT NOS3	1.81e-05	4	61	2	15625301
Pubmed	The PDGF family: four gene products form five dimeric isoforms.	PLAT PDGFC	1.81e-05	4	61	2	15207811
Pubmed	Expression of adiponectin and its receptors in type 1 diabetes mellitus in human and mouse retinas.	ADIPOR1 NOS3	1.81e-05	4	61	2	23922494
Pubmed	Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily.	UGT2A1 UGT2A2	3.02e-05	5	61	2	16141793
Pubmed	An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.	STRC STRCP1	3.02e-05	5	61	2	24920589
Pubmed	Cloning, tissue expression, and chromosomal location of the mouse insulin receptor substrate 4 gene.	GUSB BTK	4.52e-05	6	61	2	10067860
Pubmed	Mcp-1, eNOS, tPA and PAI-1 gene polymorphism and correlation of genotypes and phenotypes in hepatopulmonary syndrome.	PLAT NOS3	4.52e-05	6	61	2	17934860
Pubmed	The estimation of gametic disequilibrium between DNA markers in candidate genes for coronary artery disease (CAD) and the associations of gene complexes with risk factors for CAD.	PLAT NOS3	4.52e-05	6	61	2	11507973
Pubmed	[Analysis of gene complexes predisposing to coronary atherosclerosis].	PLAT NOS3	6.32e-05	7	61	2	11963567
Pubmed	Cryptogenic stroke in relation to genetic variation in clotting factors and other genetic polymorphisms among young men and women.	PLAT NOS3	6.32e-05	7	61	2	12468767
Pubmed	Extracellular LDLR repeats modulate Wnt signaling activity by promoting LRP6 receptor endocytosis mediated by the Itch E3 ubiquitin ligase.	ITCH LRP5	6.32e-05	7	61	2	28966723
Pubmed	Polymorphisms located in the region containing BHMT and BHMT2 genes as maternal protective factors for orofacial clefts.	BHMT2 BHMT	6.32e-05	7	61	2	20662904
Pubmed	Variants of folate metabolism genes and risk of left-sided cardiac defects.	NOS3 BHMT	8.42e-05	8	61	2	19777601
Pubmed	Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.	STRC STRCP1	8.42e-05	8	61	2	21165971
Pubmed	Genome-wide association study identifies loci affecting blood copper, selenium and zinc.	KCNV2 BHMT2 BHMT	8.93e-05	49	61	3	23720494
Pubmed	An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).	BHMT2 NOS3 BHMT	8.93e-05	49	61	3	19161160
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	ITCH SF3B1 YLPM1 CCNK	1.59e-04	154	61	4	16055720
Pubmed	Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.	STRC STRCP1	1.65e-04	11	61	2	31448880
Pubmed	Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.	STRC STRCP1	1.65e-04	11	61	2	31776257
Pubmed	Associations of folate and choline metabolism gene polymorphisms with orofacial clefts.	BHMT2 BHMT	1.97e-04	12	61	2	19737740
Pubmed	Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.	CHRNA10 CHRNG	1.97e-04	12	61	2	20584212
Pubmed	FAM188B enhances cell survival via interaction with USP7.	SF3B1 IFT172 EIF3B	2.08e-04	65	61	3	29795372
Pubmed	Sex-specific effect of insulin-dependent diabetes 4 on regulation of diabetes pathogenesis in the nonobese diabetic mouse.	CSF3R CHRNG	2.33e-04	13	61	2	15905556
Pubmed	MALDI-TOF MS genotyping of polymorphisms related to 1-carbon metabolism using common and mass-modified terminators.	NOS3 BHMT	2.72e-04	14	61	2	18988749
Pubmed	Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes.	BHMT2 BHMT	2.72e-04	14	61	2	23378610
Pubmed	Betaine-homocysteine S-methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated with plasma hyperhomocysteinemia.	BHMT2 BHMT	2.72e-04	14	61	2	30753104
Pubmed	Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4DCAF5 ubiquitin ligase.	PHF20L1 UHRF2	3.13e-04	15	61	2	29691401
Pubmed	A multilocus candidate approach identifies ACE and HIF1A as susceptibility genes for cellulite.	ADIPOR1 NOS3	3.13e-04	15	61	2	20059631
Pubmed	Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.	CHRNA10 CHRNG	3.57e-04	16	61	2	19259974
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ITCH SF3B1 OTOF IFT172 ZBTB4 YLPM1 PLEC LRBA ZNF606	3.84e-04	1285	61	9	35914814
Pubmed	Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism.	BHMT2 BHMT	4.05e-04	17	61	2	20458436
Pubmed	Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm.	BHMT2 BHMT	4.05e-04	17	61	2	18635682
Pubmed	Association of single-nucleotide polymorphisms from 17 candidate genes with baseline symptom-limited exercise test duration and decrease in duration over 20 years: the Coronary Artery Risk Development in Young Adults (CARDIA) fitness study.	ADIPOR1 NOS3	4.05e-04	17	61	2	20952631
Pubmed	Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.	STRC STRCP1	4.05e-04	17	61	2	20856818
Pubmed	High-throughput multiplex single-nucleotide polymorphism (SNP) analysis in genes involved in methionine metabolism.	BHMT2 BHMT	4.05e-04	17	61	2	18427977
Pubmed	Analysis of expansion of myeloid progenitors in mice to identify leukemic susceptibility genes.	BTK PDGFC	4.55e-04	18	61	2	16897342
Pubmed	Genetic profiling of genes from the oxidative stress pathway among North and South Indians.	PLAT NOS3	5.08e-04	19	61	2	18720901
Pubmed	Candidate genes and cerebral palsy: a population-based study.	PLAT NOS3	6.22e-04	21	61	2	18977990
Pubmed	Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.	ADIPOR1 KCNV2 IFT172 LRP5	7.59e-04	233	61	4	32290105
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	SF3B1 OTOF PLEC LRBA	7.72e-04	234	61	4	36243803
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	C2CD3 SF3B1 ABCB9 PHF20L1 LSG1 YLPM1 UGGT2 PLEC DNAH8	8.77e-04	1442	61	9	35575683
Pubmed	TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma.	SF3B1 EIF3B	1.11e-03	28	61	2	29653964
Pubmed	Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers.	SF3B1 EIF3B PLEC CHRNA10	1.12e-03	259	61	4	31162944
Pubmed	Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study.	BHMT2 BHMT	1.19e-03	29	61	2	19048631
Pubmed	Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2.	ADIPOR1 CERS6	1.19e-03	29	61	2	38485951
Pubmed	Characterization of the endogenous nonecotropic murine leukemia viruses of NZB/B1NJ and SM/J inbred strains.	GUSB PLAT	1.28e-03	30	61	2	1311971
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	VPS52 SF3B1 EIF3B PLEC	1.35e-03	272	61	4	31010829
Pubmed	Genome-wide association study of periodontal pathogen colonization.	OTOF UHRF2	1.36e-03	31	61	2	22699663
Pubmed	Sf3b4 regulates chromatin remodeler splicing and Hox expression.	SF3B1 PHF20L1	1.45e-03	32	61	2	37167859
Pubmed	Liver and brain differential expression of one-carbon metabolism genes during ontogenesis.	BHMT2 BHMT	1.54e-03	33	61	2	34702858
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	SF3B1 YLPM1 GPATCH11 CCNK	1.56e-03	283	61	4	30585729
Pubmed	The recombinant congenic strains--a novel genetic tool applied to the study of colon tumor development in the mouse.	GUSB CHRNG	1.64e-03	34	61	2	1686571
Pubmed	Joubert Syndrome	C2CD3 IFT172	1.64e-03	34	61	2	20301500
Pubmed	The genomic basis of cerebral palsy: a HuGE systematic literature review.	PLAT NOS3	1.64e-03	34	61	2	19238444
Pubmed	Transcriptional analysis of cleft palate in TGFβ3 mutant mice.	PDGFC CHRNG	1.73e-03	35	61	2	32913205
Pubmed	Genome-wide association study of selenium concentrations.	BHMT2 BHMT	1.73e-03	35	61	2	25343990
Cytoband	15q15.3	STRC STRCP1	5.11e-04	25	61	2	15q15.3
Cytoband	Ensembl 112 genes in cytogenetic band chr4q13	NPFFR2 UGT2A1 UGT2A2	1.22e-03	157	61	3	chr4q13
GeneFamily	Cholinergic receptors nicotinic subunits	CHRNA10 CHRNG	6.19e-04	16	42	2	173
GeneFamily	UDP glucuronosyltransferases	UGT2A1 UGT2A2	2.50e-03	32	42	2	363
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	C2CD3 ITCH	3.16e-03	36	42	2	823
GeneFamily	Tudor domain containing	PHF20L1 UHRF2	3.33e-03	37	42	2	780
Coexpression	GSE41867_NAIVE_VS_DAY15_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN	MTMR12 ITCH MAPK12 PHF20L1 IFT172 PANK4	6.32e-06	199	60	6	M9501
ToppCell	CF-Lymphoid-B_cell\|CF / Disease state, Lineage and Cell class	FBXW8 LRBA UHRF2 DNAH8 PRKX	6.26e-06	190	61	5	374d8fd63c733178acab07682ed1519693efab45
ToppCell	LAM-LAM\|LAM / Condition, Lineage and Cell class	ADAMTS19 BHMT2 COL14A1 PLAT BHMT	6.92e-06	194	61	5	4c6561a64711c72c4ef4a3e67c41d2e8d31fba57
ToppCell	LAM-LAM-LAM+\|LAM / Condition, Lineage and Cell class	ADAMTS19 BHMT2 COL14A1 PLAT BHMT	6.92e-06	194	61	5	4ba73a9145ed44896e359f6df9c1f32bbe24a189
Drug	Theobromine [83-67-0]; Down 200; 22.2uM; HL60; HT_HG-U133A	YLPM1 BHMT2 LRP5 PLAT PLEC CHRNA10	1.23e-05	198	59	6	2995_DN
Drug	phloroglucinaldehyde	GUSB GBA2	1.98e-05	3	59	2	CID000068099
Drug	virgaureasaponin	GUSB GBA2	1.98e-05	3	59	2	CID006324777
Drug	1-piperidinocyclohexanecarbonitrile	PLEC LRBA GBA2	3.65e-05	25	59	3	CID000062529
Drug	4-nitroso-m-cresol	GUSB GBA2	3.95e-05	4	59	2	CID000011981
Drug	4'-O-(beta-D-glucopyranosyl)-D-pantothenic acid	GUSB GBA2	3.95e-05	4	59	2	CID003082306
Drug	5-hydroxy-2-nitrobenzaldehyde	GUSB GBA2	3.95e-05	4	59	2	CID000039211
Drug	a-sophorose	GUSB LRBA GBA2	4.63e-05	27	59	3	CID000088719
Drug	CAS 520-26-3	GUSB PLAT NOS3	5.17e-05	28	59	3	CID000003594
Drug	(2S,3R)-Sphingosine	ACER1 MAPK12 SGPP2 PLAT CERS6 LRBA CHRNA10	6.39e-05	389	59	7	CID000001104
Drug	L-Methionine	BHMT2 BHMT	6.57e-05	5	59	2	DB00134
Drug	Vitamin U	BHMT2 BHMT	6.57e-05	5	59	2	ctd:D014814
Drug	AC1L8VCN	GUSB GBA2	6.57e-05	5	59	2	CID000408702
Drug	methylazoxymethyl-beta-D-glucosiduronic acid	GUSB GBA2	6.57e-05	5	59	2	CID000149476
Drug	esculin	GUSB LRBA GBA2	7.77e-05	32	59	3	CID005281417
Drug	C8-ceramide	SF3B1 ACER1 MAPK12 GUSB PLAT CERS6 GBA2 NOS3	8.92e-05	556	59	8	CID000002508
Drug	7-OHIQ	GUSB GBA2	9.84e-05	6	59	2	CID000115222
Drug	4'-O-(beta-D-glucopyranosyl)-D-hopantenic acid	GUSB GBA2	9.84e-05	6	59	2	CID000129183
Drug	X1207	GUSB GBA2	9.84e-05	6	59	2	CID000084718
Drug	chloroquine	FANCF MAPK12 GUSB COL14A1 GBA2 NOS3	9.98e-05	288	59	6	CID000002719
Drug	3-[(3S,5R,10S,13R,14S,17R)-3-[(2S,4R,5R,6S)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-14-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one	GUSB UGT2A1 PLEC	1.02e-04	35	59	3	CID010436171
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	3.80e-06	2	58	2	DOID:0110471 (implicated_via_orthology)
Disease	Abnormality of the sense of smell, COVID-19 symptoms measurement, ageusia	UGT2A1 UGT2A2	3.80e-06	2	58	2	EFO_0600019, EFO_1001758, HP_0004408
Disease	Abruptio Placentae	NOS3 BHMT	1.14e-05	3	58	2	C0000832
Disease	aortic valve disease (implicated_via_orthology)	ADAMTS19 NOS3	5.67e-05	6	58	2	DOID:62 (implicated_via_orthology)
Disease	Posterior Choroidal Artery Infarction	PLAT NOS3	2.06e-04	11	58	2	C0887799
Disease	Cerebral Infarction, Left Hemisphere	PLAT NOS3	2.06e-04	11	58	2	C0751010
Disease	Anterior Choroidal Artery Infarction	PLAT NOS3	2.06e-04	11	58	2	C0751012
Disease	Cerebral Infarction, Right Hemisphere	PLAT NOS3	2.06e-04	11	58	2	C0751011
Disease	Subcortical Infarction	PLAT NOS3	2.06e-04	11	58	2	C0751014
Disease	Cerebral Infarction	PLAT NOS3	2.06e-04	11	58	2	C0007785
Disease	MYELODYSPLASTIC SYNDROME	FANCF SF3B1 CSF3R	3.16e-04	67	58	3	C3463824
Disease	Saldino-Noonan Syndrome	C2CD3 IFT172	3.40e-04	14	58	2	C0036069
Disease	thyroxine measurement, triiodothyronine measurement	MAPK12 ABCB9	5.07e-04	17	58	2	EFO_0005130, EFO_0008392
Disease	Myasthenic Syndromes, Congenital	PLEC CHRNG	1.02e-03	24	58	2	C0751882
Disease	selenium measurement	BHMT2 BHMT	1.49e-03	29	58	2	EFO_0006331
Disease	Drug habituation	CERS6 ZNF606 DNAH8	1.52e-03	115	58	3	C0013170
Disease	Substance-Related Disorders	CERS6 ZNF606 DNAH8	1.52e-03	115	58	3	C0236969
Disease	Drug abuse	CERS6 ZNF606 DNAH8	1.52e-03	115	58	3	C0013146
Disease	Drug Use Disorders	CERS6 ZNF606 DNAH8	1.52e-03	115	58	3	C0013222
Disease	Drug Dependence	CERS6 ZNF606 DNAH8	1.52e-03	115	58	3	C1510472
Disease	Substance Dependence	CERS6 ZNF606 DNAH8	1.52e-03	115	58	3	C0038580
Disease	Substance Use Disorders	CERS6 ZNF606 DNAH8	1.52e-03	115	58	3	C0038586
Disease	Organic Mental Disorders, Substance-Induced	CERS6 ZNF606 DNAH8	1.52e-03	115	58	3	C0029231
Disease	Prescription Drug Abuse	CERS6 ZNF606 DNAH8	1.52e-03	115	58	3	C4316881
Disease	Substance abuse problem	CERS6 ZNF606 DNAH8	1.56e-03	116	58	3	C0740858
Disease	myelodysplastic syndrome (is_implicated_in)	SF3B1 CSF3R	1.59e-03	30	58	2	DOID:0050908 (is_implicated_in)
Disease	Anoxemia	PLAT NOS3	1.93e-03	33	58	2	C0003129
Disease	Hypoxemia	PLAT NOS3	1.93e-03	33	58	2	C0700292
Disease	Hypoxia	PLAT NOS3	1.93e-03	33	58	2	C0242184
Disease	Anoxia	PLAT NOS3	1.93e-03	33	58	2	C0003130
Disease	retinal degeneration (implicated_via_orthology)	IFT172 NOS3	1.93e-03	33	58	2	DOID:8466 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
WIRQEWTDAYLRWDP	CHRNA10	81	Q9GZZ6
PWVRARARKEYWENL	BHMT	341	Q93088
ERARWTETYVRWSPK	EIF3B	331	P55884
ETLKVRYWPRDSWPV	ACER1	236	Q8TDN7
YFILEESNLPWWRAR	BTK	241	Q06187
QWCDYRLRWDPRDYE	CHRNG	81	P07510
RLRWDPRDYEGLWVL	CHRNG	86	P07510
REWRRYYEVWDTEPS	A4GNT	266	Q9UNA3
WLWYEREVTLLERWI	GUSBP11	101	Q6P575
YRRWWEQFVQDVPVD	CCNK	231	O75909
PTIVRSYEWNEWELR	CFAP206	526	Q8IYR0
WWILVPAADRARRER	NPFFR2	86	Q9Y5X5
DREEWEVVFPALWRR	ADAMTS19	31	Q8TE59
ERWQLDLEDLYRPTW	PDGFC	206	Q9NRA1
KVWEGRWRVIPYDVL	ADIPOR1	86	Q96A54
WDPATVRRALQWARY	FANCF	26	Q9NPI8
PFERNLDFWRQLWRV	LSG1	156	Q9H089
IKVWAQRYLRWIPEA	MTMR12	636	Q9C0I1
GEAPYNLTWVRDWRV	HMCN2	541	Q8NDA2
DFIYWTDWQRRSIER	LRP5	556	O75197
DVRVWDTRTWDYVAP	FBXW8	231	Q8N3Y1
YDARIPQLWKRVSWD	DNAH8	4301	Q96JB1
PLEFWRLDYWEDDLR	LRBA	1976	P50851
DRLRVFNWIPRRSIW	IFT172	261	Q9UG01
EALSQDPRRYEEWKW	NOS3	891	P29474
RPWLVDSYSEWLQRL	PANK4	596	Q9NVE7
WQRPTLESVRNYEQW	ITCH	386	Q96J02
WVSFWIDRRAVPARV	GABRR3	286	A8MPY1
VPREAWYWLRLEEET	GPATCH11	206	Q8N954
KPWIRARARREYWEN	BHMT2	331	Q9H2M3
LLWYFREERLEIQVW	C2CD3	1481	Q4AC94
RYAEWEERISAWQSP	GBA2	451	Q9HCG7
RVSEEWYNRLRITWD	COL14A1	836	Q05707
RRGFEEQWYRRPLWE	GUSB	56	P08236
VGWVWYEREVILPER	GUSB	96	P08236
LDWDVRSIQRWFRQR	CERS6	106	Q6ZMG9
ERAPTVRLDTWWRQR	CSF3R	331	Q99062
PLLDWTYRDIWDFLR	FLAD1	516	Q8NFF5
CIYIKSWWPDQRRRL	OTOF	711	Q9HC10
EWIYWDSNRLRPLER	PHF20L1	56	A8MW92
WVEWYMRARPEDVIS	MPST	276	P25325
ERRRSWSYRPWNTTE	KCNV2	6	Q8TDN2
LANRRRYWELPWSEQ	STRC	1151	Q7RTU9
WNIDPYLSRRLIIIW	SGPP2	111	Q8IWX5
EVRRPIRDPWFWALF	ABCB9	106	Q9NP78
AYRIERLEWQTREWP	CNGA4	526	Q8IV77
WRYLLRRDDVEPAPW	UHRF2	606	Q96PU4
DRYWEQVLALLWPRF	VPS52	466	Q8N1B4
WLRPVLRSNRVEYCW	PLAT	56	P00750
WRWEREIDERNRPLS	SF3B1	386	O75533
QPDRPYDSNVWRWLT	TEX52	111	A6NCN8
YDPEHWVWARDRARL	SPDYE1	321	Q8NFV5
REIEWIRSRRYWPQG	TTC41P	1101	Q6P2S7
PRWRQKLERRSWEET	ZBTB4	696	Q9P1Z0
VERWRERVAQLLERW	PLEC	1311	Q15149
RWFRSVDWEAVPQRK	PRKX	301	P51817
WERERLSDRWYPSDV	YLPM1	1396	P49750
LLANRRRYWELPWSE	STRCP1	1151	A6NGW2
LVQYRWPRWLRQQTE	UGGT2	1291	Q9NYU1
EIWLIRTYWDFEFPR	UGT2A1	296	P0DTE4
EIWLIRTYWDFEFPR	UGT2A2	261	P0DTE5
LERYIWDDPWFSRLE	ZNF606	161	Q8WXB4
VVTRWYRAPEVILNW	MAPK12	186	P53778