Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbeta-adrenergic receptor kinase activity

GRK2 GRK3

1.49e-054322GO:0047696
GeneOntologyMolecularFunctionG protein-coupled receptor kinase activity

GRK2 GRK3

5.20e-057322GO:0004703
GeneOntologyCellularComponentbeta-catenin-TCF complex

TCF7L2 TCF7L1

1.75e-0413322GO:1990907
GeneOntologyCellularComponentXY body

SCML2 PLK4

5.63e-0423322GO:0001741
GeneOntologyCellularComponentlipid droplet

STARD13 GBF1 VPS13A

7.34e-04116323GO:0005811
DomainCTNNB1-bd_N

TCF7L2 TCF7L1

1.70e-054322IPR013558
DomainCTNNB1_binding

TCF7L2 TCF7L1

1.70e-054322PF08347
DomainTCF/LEF

TCF7L2 TCF7L1

1.70e-054322IPR024940
DomainGPCR_kinase

GRK2 GRK3

5.94e-057322IPR000239
DomainCatenin_binding_dom

TCF7L2 TCF7L1

1.12e-0329322IPR027397
Domain-

TCF7L2 TCF7L1

1.12e-03293224.10.900.10
DomainMAGE

MAGEB3 MAGEE1

1.54e-0334322SM01373
DomainRGS

GRK2 GRK3

1.63e-0335322PF00615
DomainRGS

GRK2 GRK3

1.63e-0335322SM00315
DomainRGS

GRK2 GRK3

1.73e-0336322PS50132
DomainMAGE

MAGEB3 MAGEE1

1.73e-0336322PS50838
DomainMHD_dom

MAGEB3 MAGEE1

1.73e-0336322IPR002190
DomainMAGE

MAGEB3 MAGEE1

1.73e-0336322PF01454
DomainRGS

GRK2 GRK3

2.03e-0339322IPR016137
DomainS_TKc

GRK2 GRK3 MYLK PLK4

3.16e-03359324SM00220
DomainPROTEIN_KINASE_ST

GRK2 GRK3 MYLK PLK4

3.25e-03362324PS00108
DomainHMG_box

TCF7L2 TCF7L1

3.71e-0353322PF00505
DomainProtein_kinase_ATP_BS

GRK2 GRK3 MYLK PLK4

3.83e-03379324IPR017441
DomainHMG_BOX_2

TCF7L2 TCF7L1

3.85e-0354322PS50118
DomainHMG

TCF7L2 TCF7L1

3.85e-0354322SM00398
DomainPkinase

GRK2 GRK3 MYLK PLK4

3.90e-03381324PF00069
Domain-

TCF7L2 TCF7L1

3.99e-03553221.10.30.10
DomainAGC-kinase_C

GRK2 GRK3

4.13e-0356322IPR000961
DomainAGC_KINASE_CTER

GRK2 GRK3

4.13e-0356322PS51285
DomainS_TK_X

GRK2 GRK3

4.13e-0356322SM00133
DomainHMG_box_dom

TCF7L2 TCF7L1

5.53e-0365322IPR009071
DomainPROTEIN_KINASE_ATP

GRK2 GRK3 MYLK PLK4

7.51e-03459324PS00107
PathwayREACTOME_MITF_M_REGULATED_MELANOCYTE_DEVELOPMENT

LARS1 TCF7L2 TCF7L1

4.32e-0539253MM17226
PathwayREACTOME_RUNX3_REGULATES_WNT_SIGNALING

TCF7L2 TCF7L1

4.51e-056252MM15542
PathwayKEGG_MEDICUS_PATHOGEN_SALMONELLA_AVRA_TO_BETA_CATENIN_SIGNALING_PATHWAY

TCF7L2 TCF7L1

4.51e-056252M47736
PathwayKEGG_MEDICUS_PATHOGEN_KSHV_LANA_TO_WNT_SIGNALING_PATHWAY

TCF7L2 TCF7L1

6.31e-057252M47465
PathwayKEGG_MEDICUS_VARIANT_CDH1_REDUCED_EXPRESSION_TO_BETA_CATENIN_SIGNALING_PATHWAY

TCF7L2 TCF7L1

8.40e-058252M47413
PathwayREACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_CELL_CYCLE_AND_PROLIFERATION

TCF7L2 TCF7L1

8.40e-058252MM17229
PathwayREACTOME_RUNX3_REGULATES_WNT_SIGNALING

TCF7L2 TCF7L1

8.40e-058252M27821
PathwayREACTOME_BINDING_OF_TCF_LEF_CTNNB1_TO_TARGET_GENE_PROMOTERS

TCF7L2 TCF7L1

8.40e-058252M27359
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_AXIN_TO_WNT_SIGNALING_PATHWAY

TCF7L2 TCF7L1

1.35e-0410252M47486
PathwayREACTOME_REPRESSION_OF_WNT_TARGET_GENES

TCF7L2 TCF7L1

1.35e-0410252MM15156
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_APC_TO_WNT_SIGNALING_PATHWAY

TCF7L2 TCF7L1

1.97e-0412252M47410
PathwayREACTOME_REPRESSION_OF_WNT_TARGET_GENES

TCF7L2 TCF7L1

2.71e-0414252M27402
PathwayREACTOME_MITF_M_DEPENDENT_GENE_EXPRESSION

TCF7L2 TCF7L1

3.57e-0416252MM17241
PathwayWP_AMPLIFICATION_AND_EXPANSION_OF_ONCOGENIC_PATHWAYS_AS_METASTATIC_TRAITS

TCF7L2 TCF7L1

4.04e-0417252M39443
PathwayREACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_CELL_CYCLE_AND_PROLIFERATION

TCF7L2 TCF7L1

4.04e-0417252M48240
PathwayREACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX

TCF7L2 TCF7L1

9.56e-0426252MM14793
PathwayKEGG_THYROID_CANCER

TCF7L2 TCF7L1

1.19e-0329252M523
PathwayREACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX

TCF7L2 TCF7L1

1.45e-0332252MM14975
PathwayREACTOME_MITF_M_REGULATED_MELANOCYTE_DEVELOPMENT

LARS1 TCF7L2 TCF7L1

1.77e-03137253M48232
PathwayKEGG_MEDICUS_VARIANT_FZD7_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY

TCF7L2 TCF7L1

1.94e-0337252M47411
PathwayWP_INFLUENCE_OF_LAMINOPATHIES_ON_WNT_SIGNALING

TCF7L2 TCF7L1

1.94e-0337252M39817
PathwayREACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX

TCF7L2 TCF7L1

2.49e-0342252M27272
PathwayWP_HEDGEHOG_SIGNALING_WP4249

GRK2 GRK3

2.61e-0343252M39706
PathwayKEGG_MEDICUS_VARIANT_LRP6_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY

TCF7L2 TCF7L1

2.85e-0345252M47412
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_PATHWAY

TCF7L2 TCF7L1

2.98e-0346252M47409
Pubmed

Cloning of GRK2 cDNA from S49 murine lymphoma cells.

GRK2 GRK3

8.20e-0723228638670
Pubmed

Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3.

GRK2 GRK3

8.20e-07232210198406
Pubmed

Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells.

GRK2 GRK3

8.20e-07232233060647
Pubmed

G-protein coupled receptor kinase 2 and 3 expression in human detrusor cultured smooth muscle cells.

GRK2 GRK3

8.20e-07232211762794
Pubmed

G protein--coupled receptor kinases.

GRK2 GRK3

8.20e-0723228035170
Pubmed

Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium.

TCF7L2 TCF7L1

8.20e-0723229916915
Pubmed

PLK4 phosphorylation of CP110 is required for efficient centriole assembly.

CCP110 PLK4

8.20e-07232228562169
Pubmed

A gene family of HMG-box transcription factors with homology to TCF-1.

TCF7L2 TCF7L1

8.20e-0723221741298
Pubmed

Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309.

GRK2 GRK3

2.46e-06332210754297
Pubmed

Wnt/beta-catenin signaling promotes expansion of Isl-1-positive cardiac progenitor cells through regulation of FGF signaling.

TCF7L2 TCF7L1

2.46e-06332217607356
Pubmed

TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state.

TCF7L2 TCF7L1

2.46e-06332234525377
Pubmed

Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus.

GRK2 GRK3

2.46e-06332210085131
Pubmed

A dynamic exchange of TCF3 and TCF4 transcription factors controls MYC expression in colorectal cancer cells.

TCF7L2 TCF7L1

2.46e-06332225659031
Pubmed

Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor.

GRK2 GRK3

2.46e-0633227761854
Pubmed

In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators.

TCF7L2 TCF7L1

2.46e-06332224463605
Pubmed

The N-termini of GRK2 and GRK3 simulate the stimulating effects of RKIP on β-adrenoceptors.

GRK2 GRK3

2.46e-06332231604529
Pubmed

The Polo kinase Plk4 functions in centriole duplication.

CCP110 PLK4

2.46e-06332216244668
Pubmed

Diverse LEF/TCF Expression in Human Colorectal Cancer Correlates with Altered Wnt-Regulated Transcriptome in a Meta-Analysis of Patient Biopsies.

TCF7L2 TCF7L1

2.46e-06332232403323
Pubmed

TCF-3, 4 protein expression correlates with beta-catenin expression in MSS and MSI-H colorectal cancer from HNPCC patients but not in sporadic colorectal cancers.

TCF7L2 TCF7L1

2.46e-06332220532534
Pubmed

Orphanin FQ/nociceptin-mediated desensitization of opioid receptor-like 1 receptor and mu opioid receptors involves protein kinase C: a molecular mechanism for heterologous cross-talk.

GRK2 GRK3

2.46e-06332212130708
Pubmed

Silencing of long noncoding RNA MYLK-AS1 suppresses nephroblastoma via down-regulation of CCNE1 through transcription factor TCF7L2.

TCF7L2 MYLK

2.46e-06332233438217
Pubmed

A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells.

TCF7L2 TCF7L1

4.92e-06432233587034
Pubmed

Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function.

GRK2 GRK3

4.92e-0643228917529
Pubmed

Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder.

GRK2 GRK3

4.92e-06432221784156
Pubmed

Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C.

GRK2 GRK3

4.92e-0643228662816
Pubmed

Mapping canonical Wnt signaling in the developing and adult retina.

TCF7L2 TCF7L1

4.92e-06432217065530
Pubmed

Hierarchical organization of multi-site phosphorylation at the CXCR4 C terminus.

GRK2 GRK3

4.92e-06432223734232
Pubmed

Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2.

TCF7L2 TCF7L1

8.19e-06532221285352
Pubmed

Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine.

GRK2 GRK3

8.19e-06532210338466
Pubmed

Plk4-induced centriole biogenesis in human cells.

CCP110 PLK4

8.19e-06532217681131
Pubmed

Dynamic expression and nuclear accumulation of beta-catenin during the development of hair follicle-derived structures.

TCF7L2 TCF7L1

1.23e-05632211731231
Pubmed

beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.

GRK2 GRK3

1.23e-0563229826657
Pubmed

Combinatorial depletions of G-protein coupled receptor kinases in immune cells identify pleiotropic and cell type-specific functions.

GRK2 GRK3

1.23e-05632236451830
Pubmed

Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse.

TCF7L2 TCF7L1

1.23e-0563229488439
Pubmed

Postnatal isoform switch and protein localization of LEF1 and TCF7L2 transcription factors in cortical, thalamic, and mesencephalic regions of the adult mouse brain.

TCF7L2 TCF7L1

1.23e-05632223152144
Pubmed

Dazap2 modulates transcription driven by the Wnt effector TCF-4.

TCF7L2 TCF7L1

1.23e-05632219304756
Pubmed

Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2.

GRK2 GRK3

1.23e-05632220074556
Pubmed

β-catenin and γ-catenin are dispensable for T lymphocytes and AML leukemic stem cells.

TCF7L2 TCF7L1

1.72e-05732232820720
Pubmed

Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration.

GRK2 GRK3

1.72e-0573228672451
Pubmed

RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis.

TCF7L2 TCF7L1

1.72e-05732218772112
Pubmed

Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function.

GRK2 GRK3

1.72e-05732211517230
Pubmed

Gene expression analysis of canonical Wnt pathway transcriptional regulators during early morphogenesis of the facial region in the mouse embryo.

TCF7L2 TCF7L1

1.72e-05732219303461
Pubmed

SELENOPROTEINS. CRL2 aids elimination of truncated selenoproteins produced by failed UGA/Sec decoding.

FEM1C PRAME

1.72e-05732226138980
Pubmed

Connective tissue fibroblasts and Tcf4 regulate myogenesis.

TCF7L2 TCF7L1

2.29e-05832221177349
Pubmed

TWIST1 Homodimers and Heterodimers Orchestrate Lineage-Specific Differentiation.

TCF7L2 TCF7L1

2.29e-05832232179550
Pubmed

Allelic variants between mouse substrains BALB/cJ and BALB/cByJ influence mononuclear cardiomyocyte composition and cardiomyocyte nuclear ploidy.

ZRSR2P1 SCML2

2.29e-05832232371981
Pubmed

Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis.

TCF7L2 TCF7L1

2.94e-05932217335794
Pubmed

Molecular determinants of response kinetics of mouse M1 intrinsically-photosensitive retinal ganglion cells.

GRK2 GRK3

2.94e-05932234873237
Pubmed

Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family.

GRK2 GRK3

3.67e-05103221869533
Pubmed

A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal.

TCF7L2 TCF7L1

3.67e-051032222393260
Pubmed

Expression of Tcf/Lef and sFrp and localization of beta-catenin in the developing mouse lung.

TCF7L2 TCF7L1

4.49e-051132211731265
Pubmed

Tcf7L2 is essential for neurogenesis in the developing mouse neocortex.

TCF7L2 TCF7L1

4.49e-051132229751817
Pubmed

Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes.

STMN2 GAD2

5.38e-051232216234809
Pubmed

Redundant and additive functions of the four Lef/Tcf transcription factors in lung epithelial progenitors.

TCF7L2 TCF7L1

5.38e-051232232414917
Pubmed

Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1.

TCF7L2 TCF7L1

5.38e-051232210631168
Pubmed

A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors.

DIAPH2 GAD2

5.38e-051232222246438
Pubmed

All Tcf HMG box transcription factors interact with Groucho-related co-repressors.

TCF7L2 TCF7L1

5.38e-051232211266540
Pubmed

Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia.

TCF7L2 TCF7L1

6.36e-051332219718027
Pubmed

Investigation of genes important in neurodevelopment disorders in adult human brain.

TCF7L2 TCF7L1

6.36e-051332226194112
Pubmed

Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization.

TCF7L2 TCF7L1

7.41e-051432215226261
Pubmed

Dose-Dependent and Subset-Specific Regulation of Midbrain Dopaminergic Neuron Differentiation by LEF1-Mediated WNT1/b-Catenin Signaling.

TCF7L2 TCF7L1

7.41e-051432233195246
Pubmed

Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice.

TCF7L2 TCF7L1

7.41e-051432210090727
Pubmed

Comparative mapping of two adjacent regions of MMU19 with their human counterpart on HSA11q13.

GRK2 AHNAK

8.55e-05153229730611
Pubmed

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation.

TCF7L2 TCF7L1

8.55e-051532215866165
Pubmed

Phases of canonical Wnt signaling during the development of mouse intestinal epithelium.

TCF7L2 TCF7L1

8.55e-051532217681174
Pubmed

Mutant Lef1 controls Gata6 in sebaceous gland development and cancer.

TCF7L2 TCF7L1

9.76e-051632230886049
Pubmed

Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.

SCML2 AHNAK PES1 WRN

1.09e-0427132432433965
Pubmed

Functional genomics identifies therapeutic targets for MYC-driven cancer.

GRK3 MYLK PES1

1.18e-0410332322623531
Pubmed

Restriction of Wnt signaling in the dorsal otocyst determines semicircular canal formation in the mouse embryo.

TCF7L2 TCF7L1

1.24e-041832222166339
Pubmed

hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells.

TCF7L2 TCF7L1

1.39e-041932235739118
Pubmed

Wnt/β-catenin signaling in the dental mesenchyme regulates incisor development by regulating Bmp4.

TCF7L2 TCF7L1

1.39e-041932220883686
Pubmed

Function of Wnt/β-catenin in counteracting Tcf3 repression through the Tcf3-β-catenin interaction.

TCF7L2 TCF7L1

1.54e-042032222573616
Pubmed

Sequential roles of Hedgehog and Wnt signaling in osteoblast development.

TCF7L2 TCF7L1

1.54e-042032215576404
Pubmed

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

CAB39 CCP110 MAGEE1 FEM1C TCF7L1

1.54e-0456432521565611
Pubmed

Tcf7l1 protects the anterior neural fold from adopting the neural crest fate.

TCF7L2 TCF7L1

1.70e-042132227302397
Pubmed

TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors.

TCF7L2 TCF7L1

1.87e-042232217919533
Pubmed

Tcf/Lef repressors differentially regulate Shh-Gli target gene activation thresholds to generate progenitor patterning in the developing CNS.

TCF7L2 TCF7L1

1.87e-042232221775418
Pubmed

Severe defects in dorsal thalamic development in low-density lipoprotein receptor-related protein-6 mutants.

GAD2 TCF7L2

1.87e-042232215342729
Pubmed

Dentate gyrus morphogenesis is regulated by β-catenin function in hem-derived fimbrial glia.

TCF7L2 TCF7L1

2.43e-042532236196585
Pubmed

Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese Europeans: the NUGENOB study.

GAD2 TCF7L2

2.43e-042532219876004
Pubmed

The Wnt effector transcription factor 7-like 2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/β-catenin signaling.

TCF7L2 TCF7L1

2.63e-042632225810530
Pubmed

Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis.

TCF7L2 TCF7L1

2.84e-042732223824573
Pubmed

Distinct adhesion-independent functions of β-catenin control stage-specific sensory neurogenesis and proliferation.

TCF7L2 TCF7L1

2.84e-042732225885041
Pubmed

Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2.

TCF7L2 RIN2

3.05e-042832224322204
Pubmed

USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.

STMN2 GAD2 ZRSR2P1 SCML2 MAGEE1

3.52e-0467432537196079
Pubmed

SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.

LARS1 PES1 WRN

3.56e-0415032330154076
Pubmed

Mutation of LRP1 in cardiac neural crest cells causes congenital heart defects by perturbing outflow lengthening.

AHNAK VPS13A

3.75e-043132232546759
Pubmed

Identification of Redox and Glucose-Dependent Txnip Protein Interactions.

SCML2 AHNAK

4.00e-043232227437069
Pubmed

Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development.

TCF7L2 TCF7L1

4.25e-043332227414999
Pubmed

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.

LARS1 SCML2 AHNAK PES1

4.54e-0439432427248496
Pubmed

Integrated analysis of Wnt signalling system component gene expression.

TCF7L2 TCF7L1

5.35e-043732235831952
Pubmed

Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis.

TCF7L2 TCF7L1

5.35e-043732215342465
Pubmed

Tissue-specific requirements of beta-catenin in external genitalia development.

TCF7L2 TCF7L1

5.65e-043832218635608
Pubmed

Association study of 182 candidate genes in anorexia nervosa.

GAD2 GRK2 GRK3

6.25e-0418232320468064
Pubmed

Bioinformatics and cellular signaling.

CCP110 TCF7L2 MYLK

6.25e-0418232315102471
Pubmed

Individual retinal progenitor cells display extensive heterogeneity of gene expression.

TCF7L2 TCF7L1

6.58e-044132218270576
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

LARS1 STARD13 TCF7L2 GBF1 TCF7L1 VPS13A

8.37e-04124232630973865
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

GBF1 AHNAK WRN

8.46e-0420232333005030
Pubmed

Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination.

TCF7L2 TCF7L1

8.64e-044732216678101
Pubmed

Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice.

DIAPH2 ZRSR2P1

8.64e-044732229617656
Cytoband22q12.1

GRK3 PES1

2.30e-043232222q12.1
CytobandEnsembl 112 genes in cytogenetic band chr5q22

ZRSR2P1 FEM1C

7.86e-0459322chr5q22
GeneFamilyMAGE family

MAGEB3 MAGEE1

7.14e-04401821136
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

GRK2 GRK3

1.75e-02206182682
CoexpressionGSE4748_CTRL_VS_LPS_STIM_DC_3H_UP

STARD13 CAB39 MAGEE1 AHNAK RIN2

4.19e-06200325M6480
CoexpressionALFANO_MYC_TARGETS

GAD2 TCF7L2 MYLK PLK4 PES1

9.96e-06239325M2477
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

STARD13 TCF7L2 GBF1 TASOR RIN2 WRN VPS13A

6.37e-05856327M4500
CoexpressionGSE3920_UNTREATED_VS_IFNG_TREATED_ENDOTHELIAL_CELL_DN

SLC25A44 GBF1 GRK2 PES1

7.25e-05184324M6696
CoexpressionGSE17974_CTRL_VS_ACT_IL4_AND_ANTI_IL12_12H_CD4_TCELL_UP

DIAPH2 OSER1 TCF7L2 AHNAK

8.90e-05194324M4192
CoexpressionGSE2405_HEAT_KILLED_VS_LIVE_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_9H_DN

CCP110 GRK3 FEM1C WRN

1.00e-04200324M6196
CoexpressionGSE4748_CTRL_VS_LPS_AND_CYANOBACTERIUM_LPSLIKE_STIM_DC_3H_UP

OSER1 CAB39 MATN2 RIN2

1.00e-04200324M6484
ToppCellControl-Neu_4|Control / 5 Neutrophil clusters in COVID-19 patients

DIAPH2 CCP110 GBF1 TASOR VPS13A

2.73e-07196325b8b7b54ca17a08fa775507bb22b1c7248ada8f40
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Proliferating_Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCP110 SCML2 TCF7L2 PLK4

8.90e-0618432416aa8e88bdd51b1d132d5cf33c29963b384a8bae
ToppCellCOVID-19_Mild-dn_T|COVID-19_Mild / Disease condition and Cell class

MAGEB3 GRK2 GRK3

7.84e-0511632379c918f3bebfd5e0b865d2c7673af9ee3bc48779
ToppCellControl-B_intermediate-1|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

GRK2 GRK3 AHNAK

1.49e-04144323984470ff6ddce4c743e2db78fa98dae055aaa273
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Myh8_Fibin|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

STARD13 GAD2 MATN2

1.92e-04157323741d79c10cb87fa7f14080c6fccb1553c3a20bad
ToppCellE18.5-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A|E18.5-samps / Age Group, Lineage, Cell class and subclass

DIAPH2 GAD2 MYLK

2.18e-04164323519ab4fe885dfe4c50846f346a062acc2cb44299
ToppCellControl-B_intermediate-1|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

GRK2 GRK3 AHNAK

2.30e-04167323948504367ecf58144d9dd74d2ec531358fc4b309
ToppCellfacs-Skin-Anagen-24m-Epithelial-bulge_keratinocyte|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCF7L2 TCF7L1 MATN2

2.30e-0416732378909f685ccd1321064eb0887caf9263e0e54879
ToppCelldroplet-Marrow-nan-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAB39 TCF7L2 GRK3

2.34e-04168323e979a4fbeb9f21048b47d69e6da75c57650697f2
ToppCellfacs-Marrow-T-cells-3m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DIAPH2 GRK3 AHNAK

2.43e-04170323a78d9789c3e7c84a36e1bd380192d7aba4a4d443
ToppCellfacs-Marrow-T-cells-3m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DIAPH2 GRK3 AHNAK

2.43e-04170323ff68600b945b3a5437b14e5411b3db800d0ccbe5
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TASOR AHNAK RIN2

2.69e-04176323749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellControl|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KANSL1L TCF7L1 AHNAK

2.73e-04177323b8ff6940e31b749776e81ae4f5bbd577dba9749c
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DIAPH2 SLC25A44 FEM1C

2.78e-04178323c87945146b2734141f07b39d268e0d8086ee0364
ToppCellfacs-Marrow-T-cells-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPA3 TASOR AHNAK

2.91e-041813237286700396676fdc41d9723979b8b408177aceb9
ToppCellCOVID-19_Severe-Classical_Monocyte-cMono_1|COVID-19_Severe / Disease condition and Cell class

GRK2 GRK3 AHNAK

2.91e-041813230d07a67e8ee3bca687b378afbc4044434e63556d
ToppCelldroplet-Marrow-nan-3m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DIAPH2 GRK3 AHNAK

2.96e-04182323bc8d621be57f76d718d9b0f11e023b0f4dcb668d
ToppCelldroplet-Lung-nan-3m-Myeloid-Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCF7L2 MATN2 RIN2

3.01e-04183323ec3c05b9ce1e0fbb720e0dea41f1e28fd3fd878f
ToppCellControl-Neu_4|World / 5 Neutrophil clusters in COVID-19 patients

CCP110 GBF1 VPS13A

3.06e-04184323ce7f044956613118ee2e9fb6af2455c3166cb414
ToppCellCOPD-Endothelial-VE_Capillary_A|COPD / Disease state, Lineage and Cell class

STARD13 MYLK RIN2

3.06e-041843235f4f7775d488ececf086c71441defecbee9d8a9c
ToppCelldroplet-Lung-nan-3m-Myeloid-alveolar_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCF7L2 MATN2 RIN2

3.06e-041843233261d767d5e3d9e9fbac22ad73ca14e44beed89c
ToppCelldroplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SCML2 TCF7L2 PLK4

3.11e-04185323b4af9ae4c358b48357cb135b740266e1652d886a
ToppCellnormal_Pleural_Fluid-Myeloid_cells-Alveolar_Mac|Myeloid_cells / Location, Cell class and cell subclass

STARD13 KANSL1L TASOR

3.16e-04186323701eea0016d69f0f9d29b613948f91239096e6c7
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

DIAPH2 GRK2 AHNAK

3.16e-0418632323b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCellCOPD-Epithelial-ATII|Epithelial / Disease state, Lineage and Cell class

STARD13 SLC25A44 TCF7L1

3.21e-04187323030af361f8bdcd0aff4ec1922702833325cf74d8
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TCF7L2 TCF7L1 AHNAK

3.21e-04187323dd1d91f101b837bba513f77defa6e6902b2c0570
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TCF7L2 TCF7L1 AHNAK

3.21e-041873234d2115a05ec36dd179ca1d4a525f2d4501aea557
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TCF7L2 TCF7L1 AHNAK

3.21e-04187323ae90c263f80c36a410150d499e268d198944a3d9
ToppCellfacs-Skin-Skin_Anagen-18m-Epithelial-outer_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCF7L2 TCF7L1 MATN2

3.31e-04189323d00410010283dc6191ce9857d6c7952678fed588
ToppCellcontrol-Myeloid-CD14_Monocytes_2|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

TCF7L2 GRK3 AHNAK

3.31e-041893237f78b5bb8195f99b18082cbb612e9199b7a1538c
ToppCellfacs-GAT-Fat-3m|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MATN2 AHNAK RIN2

3.36e-041903231d92be1b41cff59e834a9d28868f554bd1f3e471
ToppCellcontrol-Myeloid-CD14_Monocytes_2|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

TCF7L2 GRK3 AHNAK

3.36e-0419032347513757e0059e8370e49672a577f25ca842e98c
ToppCellPBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GRK2 GRK3 AHNAK

3.41e-04191323c9f3bdb5c0a90268cab24a0fe4c3a8290fcedeb8
ToppCellcontrol-Non-classical_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TCF7L2 GRK2 GRK3

3.41e-041913237122957972f177a1d846d965cef53cfe7568ba54
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD2 GRK3 RIN2

3.46e-0419232363d1b3efe93e5ff939278ebe40bacb38218ea09b
ToppCellPBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GRK2 GRK3 AHNAK

3.46e-04192323b86476037ddf8904c1d8a6b3763af7242c031cf3
ToppCellMonocytes-Inflammatory_CD16+_macrophages|World / Immune cells in Kidney/Urine in Lupus Nephritis

TCF7L2 GRK3 RIN2

3.46e-041923234be5c2c946337cd3e710137726358adca563f146
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBF1 GRK3 MATN2

3.52e-04193323fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBF1 GRK3 MATN2

3.52e-04193323471e65f02937bc18d7c5facdacdf1df58cf0f839
ToppCellPBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GRK2 GRK3 AHNAK

3.52e-041933234fb020f11fd7aff06952bfeaabc79b2c7b8873f6
ToppCellPBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GRK2 GRK3 AHNAK

3.57e-04194323885355ebe98e974f841cc59dce3b5228c642c5d0
ToppCellnucseq-Immune-Immune_Myeloid-pMON-pMON|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TCF7L2 GRK2 GRK3

3.57e-04194323e237384b02be460d44eeada3026a5691c66f6fc1
ToppCellPBMC-Severe-cDC_5|Severe / Compartment, Disease Groups and Clusters

OSER1 GRK2 FEM1C

3.57e-04194323b903e23eb75733ca516770727097fe74a9f8c1d1
ToppCellnucseq-Immune-Immune_Myeloid-pMON|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TCF7L2 GRK2 GRK3

3.57e-041943230bc83ae79873a5e473e6e1e3111924cd003986a1
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Proliferating_Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCF7L2 PLK4 MATN2

3.57e-04194323effd38e51062b225ecabc7e1c50154e65495d559
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

GRK3 MYLK MATN2

3.62e-04195323803f714d91f2d97ecbee8c15a5139fd9310f66c7
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD2 GRK3 RIN2

3.62e-0419532398ca9f3aa36211dde1e6f7f3817b9418c95e583e
ToppCellsevere-Myeloid-CD16_Monocytes|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

TCF7L2 GRK3 AHNAK

3.62e-041953235badcfdeed2fb7453a9c144506ca91c5475cd35f
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBF1 GRK3 MATN2

3.62e-04195323bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

GRK3 MYLK MATN2

3.62e-041953234f70157d42a16ff0259bc24a62803c4df4285c44
ToppCellControl-Myeloid-ncMonocyte|Control / Disease state, Lineage and Cell class

TCF7L2 GRK3 RIN2

3.62e-04195323fcb05948e7480dc53f06f3fc9b9c3fc129874edd
ToppCellControl-Myeloid-ncMonocyte|World / Disease state, Lineage and Cell class

TCF7L2 GRK3 RIN2

3.62e-04195323b4444b67a709e82b8e2ee510924c3152cb88b051
ToppCellBronchial-NucSeq|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations

DIAPH2 STARD13 KANSL1L

3.68e-04196323ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCellILEUM-non-inflamed-(9)_Neuro_cell|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

STARD13 MATN2 RIN2

3.68e-041963232b08cd6730119d5dea0152709ab8de580b66cd3c
ToppCellCOVID-19_Mild-Classical_Monocyte-cMono_3|COVID-19_Mild / Disease condition and Cell class

GRK2 GRK3 AHNAK

3.68e-04196323f245e929a286cb097130572e1027b4f01be8b04d
ToppCellCOVID-19_Mild-Classical_Monocyte-cMono_3|Classical_Monocyte / Disease condition and Cell class

GRK2 GRK3 AHNAK

3.68e-0419632315397ec27167bb2fb6fec120b68bf38fc71b2670
ToppCell10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_monocytic-classical_monocyte|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

DIAPH2 GRK3 AHNAK

3.68e-0419632328e9e191361966df3a9bd48450090577aa72a999
ToppCellILEUM-non-inflamed-(9)_Enteric_neurons|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

STARD13 MATN2 RIN2

3.68e-04196323998aa523555ed6bc9c1b5cacbf7ba77c7b218e6b
ToppCellControl-Classical_Monocyte-cMono_2|Classical_Monocyte / Disease condition and Cell class

GRK2 GRK3 AHNAK

3.73e-04197323eb7610c9496a95a5fd866e16abcbc39b83abe617
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland-Myoepithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MYLK TCF7L1 MATN2

3.73e-04197323f0475ad9c09c6da418dba17d3d3c1aaa2ef9ab4e
ToppCellCF-Myeloid-Monocyte_Macrophage|Myeloid / Disease state, Lineage and Cell class

STARD13 GRK3 AHNAK

3.73e-0419732377b150a987c0a8abe73920d93d69a590ebbbdfea
ToppCellcontrol-Myeloid-CD16_Monocytes|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

TCF7L2 GRK3 AHNAK

3.73e-04197323cdb2866d5a8fbf39847309124479ad49c88852d4
ToppCellCOVID-19_Mild-Classical_Monocyte-cMono_4|Classical_Monocyte / Disease condition and Cell class

TCF7L2 GRK2 GRK3

3.73e-04197323e666f6580e9a20b5e550f02125706db17eec8510
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

DIAPH2 STARD13 KANSL1L

3.79e-041983231996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellMonocytes|World / Immune cells in Kidney/Urine in Lupus Nephritis

TCF7L2 GRK3 RIN2

3.79e-041983238beccf03c9ec9cd02a96107a9d7ca9a6764c6a61
ToppCellPBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TCF7L2 GRK3 RIN2

3.79e-041983231ca91559fef231896e16180f5e050155c38f7cfa
ToppCellmild-Myeloid-CD16_Monocytes|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

TCF7L2 GRK3 AHNAK

3.79e-04198323ba97ff6e9d400b53ad013dce54afd7154a0f4fc9
ToppCellkidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KANSL1L MATN2 AHNAK

3.85e-04199323174f6013af6eafa577f84205a62927f2b367fda3
ToppCellCF-Myeloid-Monocyte_Macrophage|CF / Disease state, Lineage and Cell class

STARD13 GRK3 AHNAK

3.85e-04199323bf95eacb31a4a847350f9d6e95ca76c6b730c400
ToppCellILEUM-inflamed-(8)_Fibroblasts|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

STMN2 MYLK MATN2

3.85e-041993233a3e2bb21cd0293622b1a975263e918d9ba24265
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_monocytic-monocyte|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

GRK3 AHNAK RIN2

3.85e-0419932384879280851380e5bfe6bd48b6bbf57aedf6e003
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_monocytic|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

GRK3 AHNAK RIN2

3.85e-041993237dde5c02fcae64cd2d68f607500f2a46b97851fd
ToppCellNeuronal-Inhibitory-iA-iA_2(LAMP5)-LCP2--L1-4|Neuronal / cells hierarchy compared to all cells using T-Statistic

GAD2 GRK3 RIN2

3.90e-04200323f268cb1bb047e88913a828614b0a77871f5f8814
ToppCellsevere-Myeloid-CD14_Monocytes_2|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

TCF7L2 GRK3 AHNAK

3.90e-0420032327d51fefe914b90e0a16498c43607d52fd38f53c
ToppCellNeuronal-Inhibitory-iA-iA_2(LAMP5)-LCP2-|Neuronal / cells hierarchy compared to all cells using T-Statistic

GAD2 GRK3 RIN2

3.90e-042003237345cc7dc24b9174541a3e68ecac8c4c092be400
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW10-Stem_cells|GW10 / Sample Type, Dataset, Time_group, and Cell type.

TCF7L2 PLK4 TCF7L1

3.90e-04200323474e6ab48f199315f3cca86b81fdf54e0461b7b8
ToppCellControl-Control-Myeloid-immature_Neutrophil|Control / Disease, condition lineage and cell class

CCP110 GBF1 VPS13A

3.90e-04200323118321ac443feb42aee171baccfc4610f00a8822
ToppCellnormal_Lung-Fibroblasts-COL14A1+_matrix_FBs|Fibroblasts / Location, Cell class and cell subclass

SLC25A44 MATN2 AHNAK

3.90e-042003236d8f6a6b3f61c529fbed1376659641030abf4f2c
ToppCellNeuronal-Inhibitory-iA-iA_2(LAMP5)-LCP2|Neuronal / cells hierarchy compared to all cells using T-Statistic

GAD2 GRK3 RIN2

3.90e-042003235ff9ac97ef970b3b74ebb07f62a0a1f4176a10b4
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate|5w / Sample Type, Dataset, Time_group, and Cell type.

STMN2 GAD2 GRK3

3.90e-04200323c92e4fc0442404481fcac623d691dae6215b852d
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW23-Neuronal-GABAergic_neurons|GW23 / Sample Type, Dataset, Time_group, and Cell type.

STMN2 GAD2 SCML2

3.90e-04200323c6bbd33bca86ac7a76a7ba704b3e141237d04549
ToppCellControl_saline-Mesenchymal_myocytic-Pericyte-Pericyte_2|Control_saline / Treatment groups by lineage, cell group, cell type

GRK3 MYLK MATN2

3.90e-04200323bc8949eb34482aca166c4602ff6ab876cb4c2c3c
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW10-Stem_cells-Stem_cells|GW10 / Sample Type, Dataset, Time_group, and Cell type.

TCF7L2 PLK4 TCF7L1

3.90e-0420032301a29651e9bb64ef7666c6a61ec396eeb88b2816
DrugMephentermine hemisulfate [1212-72-2]; Down 200; 9.4uM; MCF7; HT_HG-U133A

OSER1 SCML2 FEM1C PLK4 RIN2 WRN VPS13A

9.14e-091973273425_DN
Drugionomycin calcium salt; Down 200; 2uM; MCF7; HT_HG-U133A_EA

DIAPH2 OSER1 SCML2 TCF7L2 GRK2 TASOR

3.01e-07198326871_DN
DrugH 85

GRK2 GRK3 MYLK

6.41e-0626323CID006439306
DrugNitrofural [59-87-0]; Down 200; 20.2uM; MCF7; HT_HG-U133A

DIAPH2 SCML2 TCF7L2 GRK2 VPS13A

7.31e-061953253320_DN
DrugMefenamic acid [61-68-7]; Down 200; 16.6uM; PC3; HT_HG-U133A

SCML2 TCF7L2 GBF1 GRK2 VPS13A

7.49e-061963251821_DN
DrugNaringin hydrate [11032-30-7]; Down 200; 6.6uM; HL60; HT_HG-U133A

SLC25A44 TCF7L2 GRK2 FEM1C AHNAK

7.87e-061983252425_DN
DrugAASM

LARS1 PES1

1.15e-054322CID000015659
DrugbetaARKct

GRK2 GRK3

2.86e-056322CID000002295
DrugW2O6

LARS1 PES1

2.86e-056322CID000518557
DrugNPC 15437

GRK2 GRK3 MYLK

3.67e-0546323CID000004548
DrugI-Q-S

GRK2 GRK3 MYLK PES1

6.57e-05156324CID000003540
DrugSCT-1

GRK2 GRK3

6.85e-059322CID000211458
Drugdihydrocytochalasin B

GRK2 GRK3 MYLK

7.38e-0558323CID000003064
Drugsecalonic acid D

LARS1 CAB39 MYLK

9.46e-0563323CID000073431
Druggeranyl nitrile

GRK2 GRK3

1.48e-0413322CID000021768
DrugDNA-PK Inhibitor III; Up 200; 1uM; MCF7; HT_HG-U133A

STARD13 KANSL1L GRK2 RIN2

1.52e-041943247543_UP
DrugAnabasine [494-52-0]; Down 200; 24.6uM; MCF7; HT_HG-U133A

DIAPH2 SCML2 TCF7L2 GRK2

1.52e-041943246774_DN
DrugIopamidol [60166-93-0]; Up 200; 5.2uM; MCF7; HT_HG-U133A

TCF7L2 GRK2 PLK4 WRN

1.52e-041943247189_UP
DrugMenadione [58-27-5]; Down 200; 23.2uM; PC3; HT_HG-U133A

STARD13 TCF7L2 TASOR VPS13A

1.52e-041943244662_DN
DrugBufexamac [2438-72-4]; Up 200; 18uM; MCF7; HT_HG-U133A

TCF7L2 GRK2 FEM1C PLK4

1.52e-041943247413_UP
Drughaloperidol; Up 200; 10uM; MCF7; HT_HG-U133A_EA

SCML2 GRK3 PRAME RIN2

1.52e-041943241024_UP
Drugp,p'-DDA

DIAPH2 GRK2 GRK3

1.53e-0474323CID000006730
DrugCyclacillin [3485-14-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A

KANSL1L TCF7L2 GRK2 VPS13A

1.55e-041953244358_DN
Drugprochlorperazine dimaleate salt; Up 200; 10uM; HL60; HT_HG-U133A

STARD13 KANSL1L PLK4 RIN2

1.55e-041953241156_UP
DrugPhenazopyridine hydrochloride [136-40-3]; Down 200; 16uM; MCF7; HT_HG-U133A

STARD13 SCML2 TCF7L2 GBF1

1.55e-041953246234_DN
DrugEthotoin [86-35-1]; Down 200; 19.6uM; MCF7; HT_HG-U133A

TCF7L2 GRK2 PLK4 RIN2

1.55e-041953246052_DN
DrugEtofenamate [30544-47-9]; Down 200; 10.8uM; MCF7; HT_HG-U133A

DIAPH2 STARD13 SCML2 TCF7L2

1.55e-041953247327_DN
DrugCatechin-(+,-) hydrate [7295-85-4]; Down 200; 13.8uM; MCF7; HT_HG-U133A

TCF7L2 GRK2 GRK3 RIN2

1.59e-041963243351_DN
DrugDroperidol [548-73-2]; Down 200; 10.6uM; MCF7; HT_HG-U133A

TCF7L2 GRK3 RIN2 VPS13A

1.59e-041963242645_DN
DrugHydrochlorothiazide [58-93-5]; Down 200; 13.4uM; MCF7; HT_HG-U133A

TCF7L2 GBF1 GRK3 RIN2

1.59e-041963241487_DN
DrugMiconazole [22916-47-8]; Down 200; 9.6uM; MCF7; HT_HG-U133A

TCF7L2 PLK4 RIN2 VPS13A

1.62e-041973241477_DN
DrugPrimidone [125-33-7]; Down 200; 18.4uM; HL60; HT_HG-U133A

DIAPH2 STMN2 MYLK RIN2

1.62e-041973243065_DN
DrugPancuronium bromide [15500-66-0]; Down 200; 5.4uM; HL60; HT_HG-U133A

KANSL1L SCML2 TCF7L2 GRK3

1.62e-041973242909_DN
DrugAnabasine [494-52-0]; Up 200; 24.6uM; HL60; HT_HG-U133A

STARD13 TCF7L2 PLK4 AHNAK

1.62e-041973242512_UP
DrugTobramycin [32986-56-4]; Down 200; 8.6uM; HL60; HT_HG-U133A

KANSL1L GRK3 FEM1C PLK4

1.62e-041973242481_DN
Drug3-Acetylcoumarin [3949-36-8]; Down 200; 21.2uM; HL60; HT_HG-U133A

KANSL1L SLC25A44 PLK4 RIN2

1.62e-041973243044_DN
Drugestradiol, USP; Up 200; 0.01uM; HL60; HT_HG-U133A

DIAPH2 GAD2 TCF7L2 GRK2

1.65e-041983242701_UP
DrugHydroxytacrine maleate (R,S) [118909-22-1]; Down 200; 12.2uM; MCF7; HT_HG-U133A

SCML2 TCF7L2 PLK4 RIN2

1.65e-041983243292_DN
DrugBetazole hydrochloride; Down 200; 27uM; MCF7; HT_HG-U133A

SLC25A44 TCF7L2 GBF1 GRK2

1.65e-041983241690_DN
DrugMonensin sodium salt [22373-78-0]; Down 200; 5.8uM; HL60; HT_HG-U133A

KANSL1L GAD2 GRK2 PLK4

1.65e-041983242580_DN
DrugChlorhexidine [55-56-1]; Down 200; 8uM; MCF7; HT_HG-U133A

DIAPH2 SLC25A44 TCF7L2 PLK4

1.65e-041983241525_DN
DrugBumetanide [28395-03-1]; Up 200; 11uM; PC3; HT_HG-U133A

KANSL1L GAD2 GRK3 PLK4

1.65e-041983245117_UP
DrugDienestrol [84-17-3]; Down 200; 15uM; MCF7; HT_HG-U133A

SLC25A44 SCML2 TCF7L2 GRK3

1.65e-041983246208_DN
DrugNaloxone hydrochloride [357-08-4]; Up 200; 11uM; PC3; HG-U133A

SLC25A44 GBF1 PRAME PES1

1.65e-041983241924_UP
DrugCeftazidime pentahydrate [78439-06-2]; Down 200; 6.2uM; MCF7; HT_HG-U133A

DIAPH2 STARD13 TCF7L2 GRK3

1.68e-041993245473_DN
DrugCaptopril [62571-86-2]; Down 200; 17.2uM; MCF7; HT_HG-U133A

TCF7L2 GBF1 GRK2 PLK4

1.68e-041993241488_DN
DrugCefazolin sodium salt [27164-46-1]; Down 200; 8.4uM; HL60; HT_HG-U133A

GAD2 TCF7L2 GRK2 PLK4

1.68e-041993242564_DN
DrugMidodrine hydrochloride [3092-17-9]; Down 200; 13.8uM; MCF7; HT_HG-U133A

SCML2 TCF7L2 PLK4 RIN2

1.68e-041993246804_DN
DrugCoralyne chloride hydrate [38989-38-7]; Up 200; 9.6uM; MCF7; HT_HG-U133A

KANSL1L GRK2 FEM1C PLK4

1.68e-041993242652_UP
DrugTyloxapol [25301-02-4]; Down 200; 4uM; HL60; HT_HG-U133A

SLC25A44 TCF7L2 FEM1C PES1

1.68e-041993243074_DN
DrugEstriol [50-27-1]; Up 200; 13.8uM; HL60; HT_HG-U133A

STARD13 TCF7L1 MATN2 AHNAK

1.71e-042003246140_UP
Drugclozapine; Down 200; 10uM; MCF7; HT_HG-U133A

DIAPH2 TCF7L2 GRK3 PLK4

1.71e-042003246947_DN
DrugSuramin sodium salt; Up 200; 10uM; PC3; HT_HG-U133A

TCF7L2 GRK3 AHNAK VPS13A

1.71e-042003247501_UP
DrugEdrophonium chloride [116-38-1]; Down 200; 19.8uM; MCF7; HT_HG-U133A

SLC25A44 TCF7L2 GRK3 PLK4

1.71e-042003241519_DN
DrugCarbamazepine [298-46-4]; Up 200; 17uM; MCF7; HT_HG-U133A

TCF7L2 GRK2 PLK4 AHNAK

1.71e-042003241683_UP
Drug8-N3cAMP

GRK2 GRK3

1.72e-0414322CID006426627
Drug8-(6-aminohexyl)amino cyclic AMP

GRK2 GRK3

1.72e-0414322CID000161999
DrugNA-382

GRK2 GRK3

1.99e-0415322CID000132534
Drugfluphenazine-N-mustard

GAD2 MYLK

2.27e-0416322CID000134141
DrugK00077

STMN2 GRK2 GRK3 MYLK

2.47e-04220324CID006419759
DrugK 252

GRK2 GRK3 MYLK

2.55e-0488323CID000003813
Drug1,3-diolein

GRK2 GRK3 MYLK

2.73e-0490323CID000033120
Drug8-azido cyclic AMP

GRK2 GRK3

2.89e-0418322CID000115296
Drugisoquinolinium

GRK2 GRK3 MYLK

3.00e-0493323CID000008405
Drug3-(1H-pyrrole-2-carboxylate

GRK2 GRK3 MYLK PES1

3.07e-04233324CID000005114
Drug8-thiomethyl-cAMP

GRK2 GRK3

3.22e-0419322CID000093140
Drug8-azidoadenosine

GRK2 GRK3

3.22e-0419322CID000160751
Drugprotocol C

LARS1 GAD2

3.58e-0420322CID000015824
Drugmetoprolol

GRK2 GRK3 PES1

4.29e-04105323CID000004171
DrugSp-8-Cl-cAMPS

GRK2 GRK3

4.34e-0422322CID000133987
DrugHA1004

GRK2 GRK3 MYLK

4.78e-04109323CID000003546
DrugSKF 38393

GAD2 GRK2 GRK3

4.91e-04110323CID000001242
DrugH-Tyr-Tic-Phe-Phe-OH

GAD2 GRK2

5.18e-0424322CID000644210
Drug1i9n

PLK4 OR1J2

5.63e-0425322CID000446239
DrugPDEs

GRK2 GRK3 MYLK

5.74e-04116323CID003036959
DrugSCH 23390

GAD2 GRK2 GRK3

5.74e-04116323CID000005018
Drugcyclizine

STMN2 GAD2 TCF7L1

5.74e-04116323CID000006726
Drugtyrphostin 23

GRK2 GRK3 MYLK

5.74e-04116323CID000002052
Drug7B-forskolin

GRK2 GRK3

6.09e-0426322CID000130638
Drugstacker

TCF7L2 TCF7L1

6.09e-0426322CID000092326
Drugamthamine

GRK2 GRK3

6.09e-0426322CID000126688
Drugamphetamine

GAD2 GRK2 GRK3 MYLK

6.47e-04284324CID000003007
DrugKemptide

GRK2 GRK3 MYLK

6.97e-04124323CID000100074
DrugAC1O5WLA

GRK2 GRK3

8.12e-0430322CID006442113
Drugallylglycine

LARS1 GAD2

8.12e-0430322CID000014044
DrugAC1L1IZ2

GRK2 GRK3 MYLK PLK4

8.34e-04304324CID000004795
DrugK-13

GAD2 CPA3

8.68e-0431322CID000469669
DrugN6-monobutyryl-cAMP

GRK2 GRK3

9.83e-0433322CID000115029
DrugAdenosine triphosphate

GRK2 GRK3

9.83e-0433322DB00171
DrugV O2

LARS1 MYLK

9.83e-0433322CID000082849
DrugRo 31

LARS1 GRK2 GRK3

1.01e-03141323CID000214797
Drugzaprinast

GRK2 GRK3 MYLK

1.01e-03141323CID000005722
Drugeg D

LARS1 GAD2

1.04e-0334322CID000029544
DrugNPLA

GRK2 GRK3

1.11e-0335322CID000004387
DrugTannins

GRK2 GRK3

1.17e-0336322CID000250395
Drugfasudil

GRK2 GRK3 MYLK

1.23e-03151323CID000003547
DrugH-1152P

GRK2 MYLK PLK4

1.30e-03154323CID000448043
DrugBolton-Hunter reagent

GRK2 GRK3

1.30e-0338322CID000123813
DrugAC1NR9P8

GRK2 GRK3

1.30e-0338322CID005287445
DrugCGS 15943

GRK2 GRK3

1.37e-0339322CID000002690
Diseasegestational diabetes (is_implicated_in)

GAD2 TCF7L2

2.79e-058302DOID:11714 (is_implicated_in)
Diseasep-cresol sulfate measurement

STARD13 GAD2

1.19e-0416302EFO_0010998
DiseaseParkinson's disease (biomarker_via_orthology)

GRK2 GRK3

4.27e-0430302DOID:14330 (biomarker_via_orthology)
DiseaseAdult Medulloblastoma

SCML2 PRAME

8.79e-0443302C0278876
DiseaseChildhood Medulloblastoma

SCML2 PRAME

8.79e-0443302C0278510
DiseaseMelanotic medulloblastoma

SCML2 PRAME

8.79e-0443302C1275668
DiseaseMedullomyoblastoma

SCML2 PRAME

8.79e-0443302C0205833
DiseaseDesmoplastic Medulloblastoma

SCML2 PRAME

8.79e-0443302C0751291
DiseaseMedulloblastoma

SCML2 PRAME

1.19e-0350302C0025149
DiseaseJT interval

GBF1 TASOR TCF7L1

2.01e-03248303EFO_0007885
DiseaseManic Disorder

GAD2 GRK3

2.38e-0371302C0024713
Diseasebipolar disorder, body mass index

TCF7L2 RIN2

2.44e-0372302EFO_0004340, MONDO_0004985
DiseaseManic

GAD2 GRK3

2.86e-0378302C0338831
DiseaseDepression, Bipolar

GAD2 GRK3

2.93e-0379302C0005587
Diseasecongestive heart failure (is_marker_for)

GRK2 GRK3

3.16e-0382302DOID:6000 (is_marker_for)
Diseaselymphocyte percentage of leukocytes

OSER1 GAD2 GBF1 TCF7L1

4.40e-03665304EFO_0007993
Diseasecoronary artery disease (is_implicated_in)

MYLK WRN

4.65e-03100302DOID:3393 (is_implicated_in)
Diseasemonocyte percentage of leukocytes

OSER1 GAD2 TCF7L2 AHNAK

6.14e-03731304EFO_0007989

Protein segments in the cluster

PeptideGeneStartEntry
MYAMKCLDKKRIKMK

GRK3

216

P35626
WHLKMPKMKMPKFSM

AHNAK

2506

Q09666
MTKYISKPENLKLMM

CAB39

246

Q9Y376
MKQKKMYKPEVSMKR

DIAPH2

626

O60879
MYAMKCLDKKRIKMK

GRK2

216

P25098
DIMKMLLMYCAKMEK

FEM1C

196

Q96JP0
MMIARFKMFPEVKEK

GAD2

251

Q05329
VTVPKMLMDMRTKYK

OR1J2

76

Q8NGS2
MKLSMKHQLPKMKTF

KANSL1L

261

A0AUZ9
MEAKKLSKDRMKKYM

MYLK

1726

Q15746
KDMKKAVAHMKYMGK

MATN2

716

O00339
FLMEMYKMKKPIMKA

MAGEB3

121

O15480
YKMKKPIMKADMLKI

MAGEB3

126

O15480
MKILKFMAKIYNKDP

MAGEE1

666

Q9HCI5
KMMDKYPEMVSRIKI

CPA3

131

P15088
RKKYMKAAEMGMPNK

CCP110

921

O43303
LKFQMEMYIKKLMEI

GBF1

491

Q92538
FMKRMKVPDYKDKAV

STARD13

646

Q9Y3M8
KKLKIFAMPMQDIKM

PRAME

211

P78395
LGSMPELKKYMKKVM

LARS1

976

Q9P2J5
ELKKYMKKVMPFVAM

LARS1

981

Q9P2J5
EKFRLYKLKMMAKME

WRN

886

Q14191
YKLKMMAKMEKYLHS

WRN

891

Q14191
DKKKFYVFGVAMTMM

SLC25A44

16

Q96H78
KMIDKKAMYKAGMVQ

PLK4

41

O00444
YLYIPKKMSHMAEMM

OSER1

276

Q9NX31
FKIMKGKIKSIYDPM

TASOR

241

Q9UK61
VEKIKVKFMTMQKMY

RIN2

651

Q8WYP3
VKFMTMQKMYSPEKK

RIN2

656

Q8WYP3
MQKMYSPEKKVMLLL

RIN2

661

Q8WYP3
SKAMVFMDVRMPKFK

VPS13A

751

Q96RL7
AIMMMKKREKYLYQK

PES1

536

O00541
VKKPLNAFMLYMKEM

TCF7L1

346

Q9HCS4
FLLKSDVMMKYMGLK

SCML2

666

Q9UQR0
KKPLNAFMLYMKEMR

TCF7L2

351

Q9NQB0
MAKTAMAYKEKMKEL

STMN2

1

Q93045
MAALEKMTFPKKMTF

ZRSR2P1

1

Q15695