Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	miRNA processing	SNIP1 DROSHA TUT7 PUM2 PUM1	1.57e-06	48	85	5	GO:0035196
GeneOntologyBiologicalProcess	regulatory ncRNA processing	SNIP1 DROSHA TUT7 PUM2 PUM1	1.36e-05	74	85	5	GO:0070918
GeneOntologyBiologicalProcess	positive regulation of extracellular matrix assembly	SOX9 CLASP1 CLASP2	2.97e-05	15	85	3	GO:1901203
GeneOntologyBiologicalProcess	embryonic body morphogenesis	CLASP1 CLASP2 ZNF281	2.97e-05	15	85	3	GO:0010172
GeneOntologyBiologicalProcess	regulation of RIG-I signaling pathway	PUM2 PUM1 SEC14L1	8.51e-05	21	85	3	GO:0039535
GeneOntologyBiologicalProcess	cytoplasmic microtubule organization	CEP120 CLASP1 CAMSAP2 TRDN	1.59e-04	66	85	4	GO:0031122
GeneOntologyBiologicalProcess	positive regulation of basement membrane assembly involved in embryonic body morphogenesis	CLASP1 CLASP2	1.66e-04	5	85	2	GO:1904261
GeneOntologyBiologicalProcess	regulation of basement membrane assembly involved in embryonic body morphogenesis	CLASP1 CLASP2	1.66e-04	5	85	2	GO:1904259
GeneOntologyBiologicalProcess	negative regulation of wound healing, spreading of epidermal cells	CLASP1 CLASP2	1.66e-04	5	85	2	GO:1903690
GeneOntologyBiologicalProcess	basement membrane assembly involved in embryonic body morphogenesis	CLASP1 CLASP2	1.66e-04	5	85	2	GO:2001197
GeneOntologyBiologicalProcess	regulation of extracellular matrix assembly	SOX9 CLASP1 CLASP2	2.28e-04	29	85	3	GO:1901201
GeneOntologyBiologicalProcess	RIG-I signaling pathway	PUM2 PUM1 SEC14L1	2.53e-04	30	85	3	GO:0039529
GeneOntologyCellularComponent	cortical microtubule cytoskeleton	CLASP1 CLASP2	1.62e-04	5	85	2	GO:0030981
GeneOntologyCellularComponent	basal cortex	CLASP1 CLASP2	3.39e-04	7	85	2	GO:0045180
GeneOntologyCellularComponent	microtubule end	CLASP1 CLASP2 CAMSAP2	4.94e-04	38	85	3	GO:1990752
Domain	Pumilio_RNA-bd	PUM2 PUM1	2.00e-05	2	84	2	IPR033712
Domain	Znf_C2H2	ZNF280A ZFAT ZNF33B ZNF556 ZNF570 TUT7 ZNF280C ZNF407 ZNF217 ZNF281 ZNF365 ZMAT1 CASZ1	5.93e-05	805	84	13	IPR007087
Domain	PUM-HD	PUM2 PUM1	5.98e-05	3	84	2	IPR033133
Domain	PUF	PUM2 PUM1	5.98e-05	3	84	2	PF00806
Domain	PUM_HD	PUM2 PUM1	5.98e-05	3	84	2	PS50303
Domain	Pumilio_RNA-bd_rpt	PUM2 PUM1	1.19e-04	4	84	2	IPR001313
Domain	DUF4195	ZNF280A ZNF280C	1.19e-04	4	84	2	PF13836
Domain	CLASP_N	CLASP1 CLASP2	1.19e-04	4	84	2	PF12348
Domain	CLASP_N_dom	CLASP1 CLASP2	1.19e-04	4	84	2	IPR024395
Domain	DUF4195	ZNF280A ZNF280C	1.19e-04	4	84	2	IPR025243
Domain	PUM	PUM2 PUM1	1.19e-04	4	84	2	PS50302
Domain	Pumilio	PUM2 PUM1	1.19e-04	4	84	2	SM00025
Domain	ARM-type_fold	DOCK1 VPS11 CLASP1 NOC3L PUM2 TSC2 CLASP2 PUM1	1.43e-04	339	84	8	IPR016024
Domain	Znf_C2H2-like	ZNF280A ZFAT ZNF33B ZNF556 ZNF570 ZNF280C ZNF407 ZNF217 ZNF281 ZNF365 ZMAT1 CASZ1	2.22e-04	796	84	12	IPR015880
Domain	ZnF_C2H2	ZNF280A ZFAT ZNF33B ZNF556 ZNF570 ZNF280C ZNF407 ZNF217 ZNF281 ZNF365 ZMAT1 CASZ1	2.55e-04	808	84	12	SM00355
Domain	ZnF_U1	TUT7 ZNF407 ZMAT1	2.95e-04	29	84	3	SM00451
Domain	Znf_U1	TUT7 ZNF407 ZMAT1	2.95e-04	29	84	3	IPR003604
Domain	FHA_dom	SNIP1 FHAD1 APLF	5.63e-04	36	84	3	IPR000253
Domain	-	SNIP1 FHAD1 APLF	5.63e-04	36	84	3	2.60.200.20
Domain	ZINC_FINGER_C2H2_1	ZNF280A ZFAT ZNF33B ZNF556 ZNF570 TUT7 ZNF280C ZNF407 ZNF217 ZNF281 CASZ1	7.01e-04	777	84	11	PS00028
Domain	ARM-like	CLASP1 NOC3L PUM2 TSC2 CLASP2 PUM1	1.37e-03	270	84	6	IPR011989
Domain	SMAD_FHA_domain	SNIP1 FHAD1 APLF	1.65e-03	52	84	3	IPR008984
Domain	-	JARID2 ARID4A	2.02e-03	15	84	2	1.10.150.60
Domain	BRIGHT	JARID2 ARID4A	2.02e-03	15	84	2	SM00501
Domain	ARID_dom	JARID2 ARID4A	2.02e-03	15	84	2	IPR001606
Domain	ARID	JARID2 ARID4A	2.02e-03	15	84	2	PS51011
Domain	ARID	JARID2 ARID4A	2.02e-03	15	84	2	PF01388
Domain	ZINC_FINGER_C2H2_2	ZNF280A ZFAT ZNF33B ZNF556 ZNF570 ZNF280C ZNF407 ZNF217 ZNF281 CASZ1	2.46e-03	775	84	10	PS50157
Domain	-	CLASP1 PUM2 TSC2 CLASP2 PUM1	3.27e-03	222	84	5	1.25.10.10
Domain	JmjC	JARID2 KDM2B	5.17e-03	24	84	2	PF02373
Domain	SH3_9	DOCK1 UBASH3B ARHGEF26	5.24e-03	78	84	3	PF14604
Domain	FHA	SNIP1 FHAD1	7.00e-03	28	84	2	SM00240
Domain	FHA_DOMAIN	SNIP1 FHAD1	8.54e-03	31	84	2	PS50006
Domain	FHA	SNIP1 FHAD1	8.54e-03	31	84	2	PF00498
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	JARID2 SNIP1 CCNT1 CRNKL1 MDN1 UACA CLASP1 DROSHA SYNE1 NOC3L BMS1 KDM2B PUM2 GPATCH4 CLASP2 ZNF217 UBN2 CAMSAP2 ZNF281 CASZ1	5.09e-10	1497	86	20	31527615
Pubmed	SOGA1 and SOGA2/MTCL1 are CLASP-interacting proteins required for faithful chromosome segregation in human cells.	CLASP1 CLASP2 MTCL1	5.83e-08	4	86	3	33587225
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	MDN1 UACA CLASP1 MAP6 SYNE1 TSC2 CLASP2 MTCL1 UBASH3B SMC2 UBN2 ARHGEF26 CAMSAP2 SPICE1	1.01e-07	963	86	14	28671696
Pubmed	Sertoli cell PUMILIO proteins modulate mouse testis size through translational control of cell cycle regulators.	SOX9 PUM2 PUM1	1.21e-06	9	86	3	35678316
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	SOX9 CCNT1 ARID4A ZNF570 ZNF280C KDM2B GPATCH4 UBN2 ZNF281 CASZ1	2.66e-06	608	86	10	36089195
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	CRNKL1 MDN1 CLASP1 XIRP2 CLASP2 HERC1 NCLN PUM1 HYDIN	4.01e-06	497	86	9	36774506
Pubmed	Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function.	CLASP1 CLASP2	6.04e-06	2	86	2	16914514
Pubmed	The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans act in small RNA biogenesis.	SNIP1 DROSHA	6.04e-06	2	86	2	18632581
Pubmed	Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics.	CLASP1 CLASP2	6.04e-06	2	86	2	12837247
Pubmed	Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins.	PUM2 PUM1	6.04e-06	2	86	2	12459267
Pubmed	Identification of diverse target RNAs that are functionally regulated by human Pumilio proteins.	PUM2 PUM1	6.04e-06	2	86	2	29165587
Pubmed	Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment.	CLASP1 CLASP2	6.04e-06	2	86	2	16866869
Pubmed	PUMILIO-mediated translational control of somatic cell cycle program promotes folliculogenesis and contributes to ovarian cancer progression.	PUM2 PUM1	6.04e-06	2	86	2	35507203
Pubmed	Bespoke RNA recognition by Pumilios.	PUM2 PUM1	6.04e-06	2	86	2	26517885
Pubmed	Mouse Pum1 and Pum2 genes, members of the Pumilio family of RNA-binding proteins, show differential expression in fetal and adult hematopoietic stem cells and progenitors.	PUM2 PUM1	6.04e-06	2	86	2	12667987
Pubmed	Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer.	PUM2 PUM1	6.04e-06	2	86	2	12771951
Pubmed	Alternate modes of cognate RNA recognition by human PUMILIO proteins.	PUM2 PUM1	6.04e-06	2	86	2	21397187
Pubmed	Golgi-derived CLASP-dependent microtubules control Golgi organization and polarized trafficking in motile cells.	CLASP1 CLASP2	6.04e-06	2	86	2	19701196
Pubmed	A Quantitative and Predictive Model for RNA Binding by Human Pumilio Proteins.	PUM2 PUM1	6.04e-06	2	86	2	31078383
Pubmed	Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization.	CLASP1 CLASP2	6.04e-06	2	86	2	10899121
Pubmed	Principles of mRNA control by human PUM proteins elucidated from multimodal experiments and integrative data analysis.	PUM2 PUM1	6.04e-06	2	86	2	32753408
Pubmed	PUMILIO proteins promote colorectal cancer growth via suppressing p21.	PUM2 PUM1	6.04e-06	2	86	2	35338151
Pubmed	Effects of PUMILIO1 and PUMILIO2 knockdown on cardiomyogenic differentiation of human embryonic stem cells culture.	PUM2 PUM1	6.04e-06	2	86	2	32437472
Pubmed	Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system.	PUM2 PUM1	6.04e-06	2	86	2	18776931
Pubmed	Characterization of RNP Networks of PUM1 and PUM2 Post-Transcriptional Regulators in TCam-2 Cells, a Human Male Germ Cell Model.	PUM2 PUM1	6.04e-06	2	86	2	32316190
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CLASP1 SYNE1 PUM2 ANKRD12 MTCL1 PUM1 CAMSAP2 ZNF365	7.86e-06	407	86	8	12693553
Pubmed	Human transcription factor protein interaction networks.	SOX9 FHAD1 ARID4A NOC3L BMS1 KDM2B PUM2 GPATCH4 ZNF217 HERC1 PUM1 UBN2 PSMD14 ZNF281	1.04e-05	1429	86	14	35140242
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	ZNF280A DOCK1 SNIP1 CASP8AP2 MDN1 TIGD2 ZNF570 DAP ANKRD12 ZNF281 HYDIN IP6K2 SPICE1	1.71e-05	1293	86	13	15342556
Pubmed	TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase.	TSC2 HERC1	1.81e-05	3	86	2	16464865
Pubmed	CLASP2 Links Reelin to the Cytoskeleton during Neocortical Development.	CLASP1 CLASP2	1.81e-05	3	86	2	28285824
Pubmed	Antagonistic and cooperative AGO2-PUM interactions in regulating mRNAs.	PUM2 PUM1	1.81e-05	3	86	2	30333515
Pubmed	Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome.	PUM2 PUM1	1.81e-05	3	86	2	33397688
Pubmed	NORAD: Defender of the Genome.	PUM2 PUM1	1.81e-05	3	86	2	27157388
Pubmed	Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network.	CLASP1 CLASP2	1.81e-05	3	86	2	17543864
Pubmed	CEP120 and SPICE1 cooperate with CPAP in centriole elongation.	CEP120 SPICE1	1.81e-05	3	86	2	23810536
Pubmed	CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta.	CLASP1 CLASP2	1.81e-05	3	86	2	16824950
Pubmed	A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection.	PUM2 PUM1	1.81e-05	3	86	2	25340845
Pubmed	PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells.	PUM2 PUM1	1.81e-05	3	86	2	28232582
Pubmed	Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins.	PUM2 PUM1	1.81e-05	3	86	2	26724866
Pubmed	CLIPs and CLASPs and cellular dynamics.	CLASP1 CLASP2	1.81e-05	3	86	2	15928712
Pubmed	Keep your fingers off my DNA: protein-protein interactions mediated by C2H2 zinc finger domains.	ZNF280C ZMAT1	1.81e-05	3	86	2	18253864
Pubmed	COP9 signalosome component CSN-5 stabilizes PUF proteins FBF-1 and FBF-2 in Caenorhabditis elegans germline stem and progenitor cells.	PUM2 PUM1	1.81e-05	3	86	2	38427913
Pubmed	A new homozygous HERC1 gain-of-function variant in MDFPMR syndrome leads to mTORC1 hyperactivation and reduced autophagy during cell catabolism.	TSC2 HERC1	1.81e-05	3	86	2	32921582
Pubmed	CLASPs prevent irreversible multipolarity by ensuring spindle-pole resistance to traction forces during chromosome alignment.	CLASP1 CLASP2	1.81e-05	3	86	2	22307330
Pubmed	Pumilio facilitates miRNA regulation of the E2F3 oncogene.	PUM2 PUM1	1.81e-05	3	86	2	22345517
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	FILIP1 MDN1 UACA CLASP1 ARID4A CAST KDM2B PUM2 ZNF217 SPICE1	2.17e-05	774	86	10	15302935
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	CCNT1 CRNKL1 NOC3L BMS1 KDM2B ZNF217 ZNF281	2.18e-05	339	86	7	30415952
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	JCAD MXRA5 MDN1 KDM2B MTCL1 NCLN ZNF281 TRDN CASZ1	2.91e-05	638	86	9	31182584
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	ZFAT UACA XIRP2 DROSHA SYNE1 RIOK3 ZNF407 CLASP2	3.29e-05	497	86	8	23414517
Pubmed	Mammalian Pum1 and Pum2 Control Body Size via Translational Regulation of the Cell Cycle Inhibitor Cdkn1b.	PUM2 PUM1	3.61e-05	4	86	2	30811992
Pubmed	E6-AP/UBE3A protein acts as a ubiquitin ligase toward SOX9 protein.	SOX9 HERC1	3.61e-05	4	86	2	24155239
Pubmed	Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi.	CCNT1 TSC2	3.61e-05	4	86	2	26350902
Pubmed	Target RNA motif and target mRNAs of the Quaking STAR protein.	PUM2 PUM1	3.61e-05	4	86	2	16041388
Pubmed	Three classes of C2H2 zinc finger proteins.	ZNF280C ZMAT1	3.61e-05	4	86	2	11361095
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	JARID2 CRNKL1 MDN1 SYNE1 ZNF280C NOC3L BMS1 GPATCH4 CLASP2 NCLN SMC2 PUM1 PSMD14	4.67e-05	1425	86	13	30948266
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	JCAD MDN1 CLASP1 KCTD8 TSC2 CLASP2 MTCL1 PUM1 CAMSAP2 SPICE1	5.32e-05	861	86	10	36931259
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	CCNT1 KDM2B ZNF217 UBN2 ZNF281 CASZ1	5.56e-05	268	86	6	33640491
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	CCNT1 CRNKL1 UACA KDM2B GPATCH4 CLASP2 ZNF217 SMC2 PSMD14 CAMSAP2 ZNF281 SPICE1	5.66e-05	1247	86	12	27684187
Pubmed	CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex.	CLASP1 CLASP2	6.01e-05	5	86	2	15631994
Pubmed	Role of CLASP2 in microtubule stabilization and the regulation of persistent motility.	CLASP1 CLASP2	6.01e-05	5	86	2	17113391
Pubmed	Prickle1 promotes focal adhesion disassembly in cooperation with the CLASP-LL5β complex in migrating cells.	CLASP1 CLASP2	6.01e-05	5	86	2	27378169
Pubmed	An Important Role of Pumilio 1 in Regulating the Development of the Mammalian Female Germline.	PUM2 PUM1	6.01e-05	5	86	2	27170441
Pubmed	A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern.	PDZD8 SEC14L1	6.01e-05	5	86	2	22683750
Pubmed	Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts.	CLASP1 CLASP2	6.01e-05	5	86	2	11290329
Pubmed	PUM1 and PUM2 exhibit different modes of regulation for SIAH1 that involve cooperativity with NANOS paralogues.	PUM2 PUM1	6.01e-05	5	86	2	30269240
Pubmed	CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover.	CLASP1 CLASP2	6.01e-05	5	86	2	24859005
Pubmed	Epiblast integrity requires CLASP and Dystroglycan-mediated microtubule anchoring to the basal cortex.	CLASP1 CLASP2	6.01e-05	5	86	2	23940118
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SNIP1 CASP8AP2 MDN1 TIGD2 ARID4A KDM2B GPATCH4 NCLN SMC2 UBN2 ZNF281 CASZ1	8.06e-05	1294	86	12	30804502
Pubmed	The RNA-binding protein Musashi-1 is produced in the developing and adult mouse eye.	PUM2 PUM1	9.01e-05	6	86	2	17768378
Pubmed	Deficient TSC1/TSC2-complex suppression of SOX9-osteopontin-AKT signalling cascade constrains tumour growth in tuberous sclerosis complex.	SOX9 TSC2	9.01e-05	6	86	2	28013293
Pubmed	Pumilio proteins utilize distinct regulatory mechanisms to achieve complementary functions required for pluripotency and embryogenesis.	PUM2 PUM1	9.01e-05	6	86	2	32198202
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	SNIP1 CCNT1 CRNKL1 MDN1 NOC3L BMS1 PUM2 GPATCH4 NCLN SMC2 PUM1 PSMD14	9.58e-05	1318	86	12	30463901
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	ZNF217 ANKRD12 CAMSAP2 ZNF281 SPICE1	9.66e-05	184	86	5	32908313
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	MDN1 CLASP1 DROSHA TUT7 NOC3L BMS1 GPATCH4 SMC2 TXLNG	1.10e-04	759	86	9	35915203
Pubmed	Proximity interactions among centrosome components identify regulators of centriole duplication.	CEP120 CLASP1 PUM1 SPICE1	1.19e-04	101	86	4	24613305
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	JCAD CLASP1 TSC2 CLASP2 MTCL1 PUM1 SPICE1	1.22e-04	446	86	7	24255178
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	CCNT1 CRNKL1 MDN1 TUT7 NOC3L BMS1 RIOK3 GPATCH4 PRR14L SMC2 PUM1 ZNF281	1.23e-04	1353	86	12	29467282
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	CCNT1 CRNKL1 ARID4A ZNF280C NOC3L CAST GPATCH4 PUM1 UBN2 ZNF281	1.24e-04	954	86	10	36373674
Pubmed	Staufen 1 is expressed by neural precursor cells in the developing murine cortex but is dispensable for NPC self-renewal and neuronal differentiation in vitro.	PUM2 PUM1	1.26e-04	7	86	2	34678304
Pubmed	Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells.	PUM2 PUM1	1.26e-04	7	86	2	25100735
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	MDN1 UACA TSC2 NCLN	1.33e-04	104	86	4	31240132
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	SNIP1 CRNKL1 NOC3L BMS1 CAST CLASP2 MTCL1 SMC2 PSMD14 APLF	1.43e-04	971	86	10	33306668
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	JARID2 SNIP1 CRNKL1 C9orf43 SMC2 ZNF281 HYDIN	1.67e-04	469	86	7	27634302
Pubmed	EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis.	KDM2B GPATCH4 ZNF281	1.80e-04	44	86	3	27505670
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	CCNT1 CRNKL1 MDN1 UBN2 ZNF281	2.32e-04	222	86	5	37071664
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	SOX9 JARID2 KDM2B	2.48e-04	49	86	3	34368113
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	CCNT1 CRNKL1 MDN1 DROSHA NOC3L BMS1 GPATCH4 SMC2 PUM1	2.49e-04	847	86	9	35850772
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	JCAD ZNF280C NOC3L BMS1 PDZD8 CLASP2 HERC1 PUM1 PSMD14 SPICE1	2.66e-04	1049	86	10	27880917
Pubmed	ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity.	CLASP1 CLASP2	2.68e-04	10	86	2	18854161
Pubmed	EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore-microtubule interactions in mitosis.	CLASP1 CLASP2	2.68e-04	10	86	2	23001180
Pubmed	The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function.	PUM2 PUM1	2.68e-04	10	86	2	23125361
Pubmed	Cellular functions of long noncoding RNAs.	PUM2 PUM1	2.68e-04	10	86	2	31048766
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	SNIP1 CRNKL1 CLASP1 CLASP2 MTCL1 F5	2.81e-04	361	86	6	26167880
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	GARIN5B ZFAT XIRP2 SYNE1 CASZ1	2.90e-04	233	86	5	37704626
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DOCK1 GALNT2 ZNF33B UACA CAST DAP CLASP2 ANKRD12 UBN2 ARHGEF26 ZMAT1 CASZ1	2.96e-04	1489	86	12	28611215
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	C1orf185 AXDND1 C9orf43 TIGD2 CAST IL1RL2 HYDIN CCDC7	3.02e-04	686	86	8	29987050
Pubmed	Non-proteolytic ubiquitination of OTULIN regulates NF-κB signaling pathway.	TSC2 PUM1	3.28e-04	11	86	2	31504727
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	MAP6 TUT7 CAST UNC13D CLASP2 ANKRD12 HERC1 PUM1 UBN2 ZMAT1	3.45e-04	1084	86	10	11544199
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	CCNT1 DROSHA MTCL1 ZNF281 TXLNG	3.45e-04	242	86	5	34011540
Pubmed	MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity.	CLASP1 CLASP2 CAMSAP2	3.88e-04	57	86	3	29089450
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZFAT ZNF33B ZNF556 ZNF570 ZNF407 ZNF217 ZNF281 ZNF365 CASZ1	6.88e-05	718	46	9	28
GeneFamily	AT-rich interaction domain containing	JARID2 ARID4A	6.51e-04	15	46	2	418
Coexpression	GSE20484_MCSG_VS_CXCL4_MONOCYTE_DERIVED_MACROPHAGE_DN	JARID2 CLASP1 PUM2 ANKRD12 HERC1 AAGAB SEC14L1	3.16e-06	195	84	7	M7382
Coexpression	GSE22103_LPS_VS_GMCSF_AND_IFNG_STIM_NEUTROPHIL_DN	JCAD ZNF280C NOC3L KDM2B ZNF407 ZNF217 PRR14L	3.74e-06	200	84	7	M7791
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	DOCK1 SOX9 JARID2 MDN1 CLASP1 ARID4A PUM2 CLASP2 MTCL1 PUM1 CAMSAP2 SEC14L1	1.78e-05	856	84	12	M4500
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	JARID2 MDN1 CLASP1 PUM2 CLASP2 MTCL1 PUM1 CAMSAP2 SEC14L1	1.86e-05	466	84	9	M13522
Coexpression	GSE29949_MICROGLIA_BRAIN_VS_CD8_NEG_DC_SPLEEN_UP	JCAD CCNT1 VPS11 GALNT2 ANKRD12 MTCL1	3.94e-05	195	84	6	M8421
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HGABA	MDN1 ARID4A MAP6 KDM2B TSC2 ANKRD12 HERC1 UBASH3B UBN2 CAMSAP2 ZMAT1 HYDIN CASZ1	4.85e-05	1106	84	13	M39071
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Calb2_Pdlim5\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	FILIP1 KCTD8 UBASH3B SMC2 CASZ1	1.47e-05	160	86	5	dd16ca90feb3ae88b6409d6c278b4765da565514
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	FILIP1 KCTD8 UBASH3B SMC2 CASZ1	1.97e-05	170	86	5	8ab67e2b6e30fdf9e9a2c02e31d4df34e751a3ed
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	MDN1 SYNE1 PDZD8 ANKRD12 HERC1	2.40e-05	177	86	5	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	UACA MAP6 ARHGEF26 F5 CASZ1	2.81e-05	183	86	5	3c516fe5083f02bad1f464ed284010b4131a833c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	UACA MAP6 ARHGEF26 F5 CASZ1	2.81e-05	183	86	5	9c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	UACA MAP6 ARHGEF26 F5 CASZ1	2.89e-05	184	86	5	7294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AXDND1 UACA MAP6 ARHGEF26 F5	3.20e-05	188	86	5	9db778c1d9e622a68337212296e3a1ed8f771fa5
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AXDND1 UACA MAP6 ARHGEF26 F5	3.20e-05	188	86	5	047c4e0b03fc8334e38c48977e41d26dbe229d47
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	JCAD UACA SYNE1 CASZ1 SEC14L1	3.36e-05	190	86	5	0e9847d7f49b2236b8a191e1a7df37556351ba9e
ToppCell	COVID-19_Mild-PLT_4\|World / Disease Group and Platelet Clusters	ZFAND1 ARID4A XIRP2 TUT7 ANKRD12	3.62e-05	193	86	5	98a52523aa1efd5d14a2878ed106828a80a33aa2
ToppCell	moderate-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	FILIP1 FHAD1 MAP6 SYNE1 HYDIN	3.81e-05	195	86	5	3486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell	PSB-critical-LOC-Epithelial-Ciliated\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FILIP1 FHAD1 MAP6 SYNE1 HYDIN	4.00e-05	197	86	5	6865f4831eb23794fb88a8649d48d497bbae3f44
ToppCell	H1299-infected-SARSCoV2\|infected / Cell line, Condition and Strain	UACA ARID4A TUT7 GPATCH4 ANKRD12	4.00e-05	197	86	5	0fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell	COVID-19_Mild-PLT_4\|COVID-19_Mild / Disease Group and Platelet Clusters	ZFAND1 ARID4A XIRP2 TUT7 ANKRD12	4.09e-05	198	86	5	3d8c33dba759df0974aeb2b9a6b5167ae7a18e1f
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CCNT1 SYNE1 ZNF407 ANKRD12 HERC1	4.19e-05	199	86	5	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK1 CLASP1 ZNF407 CLASP2 HERC1	4.19e-05	199	86	5	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-H\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	SOX9 GALNT2 GPATCH4 NCLN PSMD14	4.29e-05	200	86	5	0ebc54d19873a2b7b6d12b81559cb12abd73b90c
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuroepithelial\|5w / Sample Type, Dataset, Time_group, and Cell type.	JCAD FHAD1 MXRA5 UNC13D APLF	4.29e-05	200	86	5	69707f9576d326a06faac49701ef5cd632e760f6
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuroepithelial-Proteoglycan-expressing_cell\|5w / Sample Type, Dataset, Time_group, and Cell type.	JCAD FHAD1 MXRA5 UNC13D APLF	4.29e-05	200	86	5	f94381d0a3b5b81cdbb13b75fc0e4910cbd70382
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal\|6m / Sample Type, Dataset, Time_group, and Cell type.	FILIP1 XIRP2 F5 TRDN HYDIN	4.29e-05	200	86	5	13ec8afea86e4a10599c924871ba4e325b0a8013
Drug	Digoxin [20830-75-5]; Up 200; 5.2uM; MCF7; HT_HG-U133A	SNIP1 CCNT1 ARID4A RIOK3 ANKRD12 PUM1 IP6K2	3.20e-06	166	86	7	5324_UP
Disease	forced expiratory volume	JCAD FILIP1 ZFAT CEP120 DROSHA SYNE1 RIOK3 MTCL1 AAGAB ZNF365 TXLNG CASZ1	2.09e-06	789	83	12	EFO_0004314
Disease	ascending aortic diameter	CEP120 NOC3L CAST UNC13D HYDIN	4.83e-05	140	83	5	EFO_0021787
Disease	ocular hypertension, response to triamcinolone acetonide	TUT7 RIOK3 ZNF217	3.60e-04	49	83	3	EFO_0006954, EFO_1001069
Disease	atrial fibrillation	C1orf185 FILIP1 ZFAT HERC1 CASZ1 CCDC7	6.34e-04	371	83	6	EFO_0000275
Disease	uterine fibroid	SYNE1 KCTD8 ANKRD12 CASZ1	2.43e-03	199	83	4	EFO_0000731

Protein segments in the cluster

Peptide	Gene	Start	Entry
EIEHKTKDHQTFKKP	ZNF280A	466	P59817
IVQKHPHTGDTKEEK	DAP	26	P51397
HHHEPKVKEEKKDLE	ARID4A	411	P29374
KHKIATKRTPHKEDE	APLF	306	Q8IW19
KEKHNAKLIHDKIEP	CCDC7	36	Q96M83
HKRKHEKQERGEPAA	CASZ1	1591	Q86V15
HIKAIKDHSKDEPQL	C1orf185	96	Q5T7R7
QKSDEKIVIHHKPLR	ARHGEF26	401	Q96DR7
VEDSVTKSREHKEKH	CCNT1	496	O60563
HDKEKPEKERHLAES	ANKRD12	911	Q6UB98
PEKERHLAESKEKHL	ANKRD12	916	Q6UB98
QDLKTKKHHIPVVDR	BMS1	61	Q14692
DLNHPHKKQRKETDL	CASP8AP2	1841	Q9UKL3
ARHKAQPAHEAVEKE	CACNA1B	981	Q00975
HHELKTVEEKRAKAE	MTCL1	436	Q9Y4B5
IQHVLEHGRPEDKSK	PUM2	926	Q8TB72
KQHHVKADKRDPEFV	NCLN	491	Q969V3
PHFVHRELKSEKVEQ	NXF3	191	Q9H4D5
IVSPKQEHEDRKHDK	KCTD8	326	Q6ZWB6
QEHEDRKHDKVTDKG	KCTD8	331	Q6ZWB6
LHVEPKRKEHSEKKQ	KIAA0100	1781	Q14667
RTDKAHKETENEKPE	MDN1	5241	Q9NU22
KKDPVKIVRCHEHTE	MCTS2	46	A0A3B3IRV3
KDQDVVVPEHAKVHD	MAP6	681	Q96JE9
NKKHHVLETEKTPKD	IP6K2	116	Q9UHH9
SREEKEHPAAQKEKS	JCAD	1326	Q9P266
NEIDPIKKKDLHHSN	GALNT2	46	Q10471
KKHRHESEEKGDVEQ	HERC1	2416	Q15751
DEKHPEHAEQNIRKS	GPATCH4	226	Q5T3I0
QEKKKHAVASDPRHL	FCRL5	931	Q96RD9
SDHHVVTNVEKEKEP	PDZD8	801	Q8NEN9
AHELQKIPHKEVDKA	NLRP2	36	Q9NX02
IQHVLEHGRPEDKSK	PUM1	1046	Q14671
KPHKESQRHAVDALV	IL1RL2	391	Q9HB29
KKQQQEKEDAEHHPD	CRNKL1	826	Q9BZJ0
IKELEKARSPDHKDH	FHAD1	1161	B1AJZ9
EENKPHVKAKKAHTA	HYDIN	3546	Q4G0P3
EDHPPRKRHAAEKQK	KDM2B	11	Q8NHM5
LQEHPEAHEKIEKLK	DOCK1	1551	Q14185
LKTQNEHEPEHSKKK	CEP120	351	Q8N960
RAHDVKLTKETEKAH	AXDND1	341	Q5T1B0
PEETEIHVSQHGKKK	C9orf43	141	Q8TAL5
DEEEKKHVSFKKPHQ	DEFB128	56	Q7Z7B8
VVHEKKSQEGKPKEH	CAST	46	P20810
CVPKEKDKLSHIHDQ	DEFB115	66	Q30KQ5
LQETHKGKIPKDEHI	SEC14L1	266	Q92503
QKKQRPKSIHRDHIE	CAMSAP2	1261	Q08AD1
TQKLEDQKEERLHHP	PRR14L	1461	Q5THK1
GKQDPKRHLEEHVDV	PSMD14	276	O00487
KAKRELVKDTKPNHH	JARID2	351	Q92833
SSEPVHAKKRKHERI	NOC3L	116	Q8WTT2
AEIKRKKAHPDRLHD	DROSHA	506	Q9NRR4
HHSTVKVKQEREDHP	SNIP1	101	Q8TAD8
KKEESPEHKEINHLN	SYNE1	4201	Q8NF91
EHAKHKGPKVERDQA	F5	861	P12259
ELRKKLQEEEHHSKE	FILIP1	406	Q7Z7B0
EEAERLRVQHKKDHP	SOX9	156	P48436
PEDLVRRHEIHKSKN	SPICE1	46	Q8N0Z3
AATLPHEQRKVHAEK	AAGAB	276	Q6PD74
KRPKHENHKHADVIV	CLCA4	91	Q14CN2
KTLEAHKDSHKEVVR	CLASP1	1391	Q7Z460
AHKDPHKEVVRSAEE	CLASP2	1151	O75122
HEKKEHSTAEKAVDP	RIOK3	221	O14730
ITERKHEHLKNKSAP	XIRP2	2661	A4UGR9
RKTELNPEKHISHKA	TIGD2	466	Q4W5G0
SPEDHQKRIKKHFDS	UGT3A1	81	Q6NUS8
KHIRDAHDPQDKKVK	ZFAT	371	Q9P243
RKKLIHTEDPFNDEH	UBN2	156	Q6ZU65
HEKDPQVKEKLHAEA	VPS11	636	Q9H270
KHDETHTREKNEVLK	ZNF33B	181	Q06732
HEHSKDRKPFEVVAE	ZNF365	106	Q70YC5
HKHERKHTGEKPVNA	ZNF556	386	Q9HAH1
HHGTEEPKQDTNVKK	ZNF281	206	Q9Y2X9
KELDHNISKHKREAE	SMC2	911	O95347
HVKPEEHEQVKSRLE	UACA	681	Q9BZF9
EKHVEPAKSPKKEHS	TRDN	401	Q13061
KIIPKEEKVHKHDTQ	ZNF570	181	Q96NI8
PNKESLIEHRKVHTK	ZNF217	226	O75362
RHQSDHECEKLEIPK	ZFAND1	91	Q8TCF1
AEHKAQHRTFIKPKE	ZNF280C	486	Q8ND82
AASKTEVHVEPHKKQ	UBASH3B	196	Q8TF42
SEKDVEEHKATEKHI	ZNF407	626	Q9C0G0
EVINHHPDVQTKDDK	TUT7	656	Q5VYS8
REEHIDKVFKHKELQ	TXLNG	286	Q9NUQ3
RETQKHKKDLHPLFD	UNC13D	966	Q70J99
PTKDVDKHRCDKKRH	TSC2	1626	P49815
SHDVPSEKEERKHRK	ZMAT1	601	Q5H9K5
EHADVRKKPAEKKSH	GARIN5B	241	Q8N5Q1
KPAKIEHKEENDHKV	MXRA5	2241	Q9NR99