Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein-arginine deiminase activity	PADI4 PADI2 PADI3	3.93e-07	5	69	3	GO:0004668
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	PADI4 PADI2 PADI3	6.39e-06	11	69	3	GO:0016813
GeneOntologyMolecularFunction	histone H3 arginine deiminase activity	PADI4 PADI2	1.18e-05	2	69	2	GO:0141057
GeneOntologyMolecularFunction	histone H3R26 arginine deiminase activity	PADI4 PADI2	1.18e-05	2	69	2	GO:0140798
GeneOntologyMolecularFunction	histone arginine deiminase activity	PADI4 PADI2	1.18e-05	2	69	2	GO:0140794
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	EP400 CECR2 XRCC5 DHX30	9.80e-04	127	69	4	GO:0008094
Domain	PAD_C	PADI4 PADI2 PADI3	4.39e-07	5	67	3	IPR013530
Domain	Prot_Arg_deaminase_cen_dom	PADI4 PADI2 PADI3	4.39e-07	5	67	3	IPR013733
Domain	PAD_N	PADI4 PADI2 PADI3	4.39e-07	5	67	3	IPR013732
Domain	PAD	PADI4 PADI2 PADI3	4.39e-07	5	67	3	PF03068
Domain	PAD_N	PADI4 PADI2 PADI3	4.39e-07	5	67	3	PF08526
Domain	PAD_M	PADI4 PADI2 PADI3	4.39e-07	5	67	3	PF08527
Domain	PAD	PADI4 PADI2 PADI3	4.39e-07	5	67	3	IPR004303
Domain	Cupredoxin	PADI4 PADI2 PADI3	6.47e-05	22	67	3	IPR008972
Domain	VWF_A	BABAM1 SEC24B XRCC5 SVEP1	4.41e-04	99	67	4	IPR002035
Domain	AT_hook	KMT2C CECR2	1.47e-03	16	67	2	PF02178
Domain	-	SEC24B XRCC5 SVEP1	2.38e-03	74	67	3	3.40.50.410
Domain	Homeobox_Antennapedia_CS	HOXB8 HOXC5	2.55e-03	21	67	2	IPR001827
Domain	ANTENNAPEDIA	HOXB8 HOXC5	3.33e-03	24	67	2	PS00032
Domain	Bromodomain_CS	CECR2 CREBBP	3.90e-03	26	67	2	IPR018359
Domain	Ig_I-set	ICAM5 NFASC IGSF9B DCC	4.83e-03	190	67	4	IPR013098
Domain	I-set	ICAM5 NFASC IGSF9B DCC	4.83e-03	190	67	4	PF07679
Domain	HMGI/Y_DNA-bd_CS	KMT2C CECR2	5.51e-03	31	67	2	IPR000637
Domain	DNA/RNA_helicase_DEAH_CS	EP400 DHX30	6.99e-03	35	67	2	IPR002464
Pubmed	Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines.	PADI4 PADI2 PADI3	8.87e-09	3	73	3	32098295
Pubmed	The amount of citrullinated proteins in synovial tissue is related to serum anti-cyclic citrullinated peptide (anti-CCP) antibody levels.	PADI4 PADI2 PADI3	8.87e-09	3	73	3	26255191
Pubmed	Peptidylarginine deiminase 1-catalyzed histone citrullination is essential for early embryo development.	PADI4 PADI2 PADI3	3.54e-08	4	73	3	27929094
Pubmed	Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse.	PADI4 PADI2 PADI3	3.54e-08	4	73	3	10092850
Pubmed	Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6.	PADI4 PADI2 PADI3	1.77e-07	6	73	3	15087120
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	GDPD5 SYNRG KMT2C HIVEP2 TRIB3 EP400 POLRMT MED14 NINL PLXNB2 ATP13A2 KCNH3 DHX30	4.62e-07	1105	73	13	35748872
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	SYNRG KMT2C EP400 ICAM5 ARFGAP1 SEC24B BUB1B MED14 CREBBP	2.26e-06	549	73	9	38280479
Pubmed	Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis.	PADI4 PADI2	4.35e-06	2	73	2	23118341
Pubmed	Association of cross-reactive antibodies targeting peptidyl-arginine deiminase 3 and 4 with rheumatoid arthritis-associated interstitial lung disease.	PADI4 PADI3	4.35e-06	2	73	2	24901704
Pubmed	The human peptidylarginine deiminases type 2 and type 4 have distinct substrate specificities.	PADI4 PADI2	4.35e-06	2	73	2	24594197
Pubmed	Comparison of enzymatic properties between hPADI2 and hPADI4.	PADI4 PADI2	4.35e-06	2	73	2	15629448
Pubmed	PAD enzymes in rheumatoid arthritis: pathogenic effectors and autoimmune targets.	PADI4 PADI2	4.35e-06	2	73	2	32341463
Pubmed	Reciprocal regulation of Th2 and Th17 cells by PAD2-mediated citrullination.	PADI4 PADI2	4.35e-06	2	73	2	31723060
Pubmed	Increased citrullination and expression of peptidylarginine deiminases independently of P. gingivalis and A. actinomycetemcomitans in gingival tissue of patients with periodontitis.	PADI4 PADI2	4.35e-06	2	73	2	30064459
Pubmed	Contact with stimulated T cells up-regulates expression of peptidylarginine deiminase 2 and 4 by human monocytes.	PADI4 PADI2	4.35e-06	2	73	2	22614825
Pubmed	Molecular Factors in PAD2 (PADI2) and PAD4 (PADI4) Are Associated with Interstitial Lung Disease Susceptibility in Rheumatoid Arthritis Patients.	PADI4 PADI2	4.35e-06	2	73	2	37759458
Pubmed	Relative efficiencies of peptidylarginine deiminase 2 and 4 in generating target sites for anti-citrullinated protein antibodies in fibrinogen, alpha-enolase and histone H3.	PADI4 PADI2	4.35e-06	2	73	2	30161253
Pubmed	Peptidyl arginine deiminase type 2 (PAD-2) and PAD-4 but not PAD-1, PAD-3, and PAD-6 are expressed in rheumatoid arthritis synovium in close association with tissue inflammation.	PADI4 PADI2	4.35e-06	2	73	2	17968929
Pubmed	Peptidylarginine deiminase 2 is required for tumor necrosis factor alpha-induced citrullination and arthritis, but not neutrophil extracellular trap formation.	PADI4 PADI2	4.35e-06	2	73	2	28188029
Pubmed	The Clinical and Prognostic Significance of Protein Arginine Deiminases 2 and 4 in Colorectal Cancer.	PADI4 PADI2	4.35e-06	2	73	2	34569542
Pubmed	ARFGAP1 promotes the formation of COPI vesicles, suggesting function as a component of the coat.	COPA ARFGAP1	4.35e-06	2	73	2	12379802
Pubmed	Peptidylarginine Deiminase Inhibitor Application, Using Cl-Amidine, PAD2, PAD3 and PAD4 Isozyme-Specific Inhibitors in Pancreatic Cancer Cells, Reveals Roles for PAD2 and PAD3 in Cancer Invasion and Modulation of Extracellular Vesicle Signatures.	PADI2 PADI3	4.35e-06	2	73	2	33573274
Pubmed	The expression of mRNA for peptidylarginine deiminase type 2 and type 4 in bone marrow CD34+ cells in rheumatoid arthritis.	PADI4 PADI2	4.35e-06	2	73	2	29148420
Pubmed	Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid.	PADI4 PADI2	4.35e-06	2	73	2	26245941
Pubmed	Myelin localization of peptidylarginine deiminases 2 and 4: comparison of PAD2 and PAD4 activities.	PADI4 PADI2	4.35e-06	2	73	2	18227806
Pubmed	Padi2/3 Deficiency Alters the Epigenomic Landscape and Causes Premature Differentiation of Mouse Trophoblast Stem Cells.	PADI2 PADI3	4.35e-06	2	73	2	36010543
Pubmed	In vivo expression of peptidylarginine deiminase in Drosophila melanogaster.	PADI4 PADI2	4.35e-06	2	73	2	31940417
Pubmed	Anti-Citrullinated Protein Antibody Reactivity towards Neutrophil-Derived Antigens: Clonal Diversity and Inter-Individual Variation.	PADI4 PADI2	4.35e-06	2	73	2	37189377
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	MIIP SYNRG HIVEP2 ARFGAP1 SEC24B BUB1B GAN PAK6 RTKN SPICE1	1.25e-05	861	73	10	36931259
Pubmed	TEFM (c17orf42) is necessary for transcription of human mtDNA.	POLRMT DHX30	1.30e-05	3	73	2	21278163
Pubmed	Synovial fluid is a site of citrullination of autoantigens in inflammatory arthritis.	PADI4 PADI2	1.30e-05	3	73	2	18668562
Pubmed	Uncommon somatic mutations in metastatic NUT midline carcinoma.	KMT2C DCC	1.30e-05	3	73	2	28967088
Pubmed	Peptidylarginine deiminases and deimination in biology and pathology: relevance to skin homeostasis.	PADI2 PADI3	1.30e-05	3	73	2	16973334
Pubmed	Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300.	EP400 CREBBP	1.30e-05	3	73	2	9590171
Pubmed	Involvement of Brain-Enriched Guanylate Kinase-Associated Protein (BEGAIN) in Chronic Pain after Peripheral Nerve Injury.	ICAM5 BEGAIN	1.30e-05	3	73	2	27785460
Pubmed	Three types of mouse peptidylarginine deiminase: characterization and tissue distribution.	PADI2 PADI3	1.30e-05	3	73	2	1778991
Pubmed	ATP induces protein arginine deiminase 2-dependent citrullination in mast cells through the P2X7 purinergic receptor.	PADI4 PADI2	1.30e-05	3	73	2	22984079
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CNOT6 KMT2C EP400 TECPR2 CECR2 NINL NFASC PADI2	1.54e-05	529	73	8	14621295
Pubmed	MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.	KMT2C CREBBP	2.60e-05	4	73	2	28398509
Pubmed	PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease.	PADI2 PADI3	2.60e-05	4	73	2	14579251
Pubmed	Binding and modulation of p53 by p300/CBP coactivators.	EP400 CREBBP	2.60e-05	4	73	2	9194565
Pubmed	Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis.	PADI4 PADI2	2.60e-05	4	73	2	33055424
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	SYNRG EP400 ARFGAP1 SEC24B CORO7 PPP1R13L CREBBP	4.16e-05	444	73	7	34795231
Pubmed	Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.	XRCC5 CREBBP	4.33e-05	5	73	2	15023334
Pubmed	A pro-apoptotic function of iASPP by stabilizing p300 and CBP through inhibition of BRMS1 E3 ubiquitin ligase activity.	PPP1R13L CREBBP	4.33e-05	5	73	2	25675294
Pubmed	SIRT2 induces the checkpoint kinase BubR1 to increase lifespan.	BUB1B CREBBP	4.33e-05	5	73	2	24825348
Pubmed	MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ.	KMT2C PAGR1	4.33e-05	5	73	2	32601106
Pubmed	A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.	KMT2C PAGR1	4.33e-05	5	73	2	26744420
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	SYNRG COPA ARFGAP1 SEC24B BUB1B PAGR1 PPP1R13L RTKN SPICE1 BEGAIN	6.08e-05	1038	73	10	26673895
Pubmed	Proximity labeling reveals dynamic changes in the SQSTM1 protein network.	SYNRG ARFGAP1 SEC24B BUB1B CORO7 PPP1R13L	6.08e-05	322	73	6	39098523
Pubmed	Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy.	EP400 NFASC	6.48e-05	6	73	2	31142747
Pubmed	Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex.	XRCC5 CREBBP	6.48e-05	6	73	2	9488450
Pubmed	Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination.	PADI4 CREBBP	6.48e-05	6	73	2	15731352
Pubmed	ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.	KMT2C PAGR1	9.06e-05	7	73	2	19556342
Pubmed	Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.	KMT2C POLRMT MED14 PAGR1	1.18e-04	119	73	4	23508102
Pubmed	Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86.	XRCC5 CREBBP	1.21e-04	8	73	2	15075319
Pubmed	An ENU-mutagenesis screen in the mouse: identification of novel developmental gene functions.	SEC24B PLXNB2	1.21e-04	8	73	2	21559415
Pubmed	Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses.	HOXB8 CREBBP	1.55e-04	9	73	2	35675826
Pubmed	The ARF1 GTPase-activating protein: zinc finger motif and Golgi complex localization.	COPA ARFGAP1	1.55e-04	9	73	2	8533093
Pubmed	New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice.	HOXB8 HOXC5 NODAL	1.62e-04	50	73	3	28188179
Pubmed	Insights into COPI coat assembly and function in living cells.	COPA ARFGAP1	1.93e-04	10	73	2	16956762
Pubmed	SUMOylation of pontin chromatin-remodeling complex reveals a signal integration code in prostate cancer cells.	EP400 CREBBP	1.93e-04	10	73	2	18087039
Pubmed	SVEP1 is an endogenous ligand for the orphan receptor PEAR1.	COPA SVEP1	2.36e-04	11	73	2	36792666
Pubmed	Dynamic SUMOylation of MORC2 orchestrates chromatin remodelling and DNA repair in response to DNA damage and drives chemoresistance in breast cancer.	XRCC5 DHX30	2.83e-04	12	73	2	36793866
Pubmed	DDX39B facilitates the malignant progression of hepatocellular carcinoma via activation of SREBP1-mediated de novo lipid synthesis.	GAN XRCC5 DHX30	3.22e-04	63	73	3	37052853
Pubmed	Semaphorin 4D signaling requires the recruitment of phospholipase C gamma into the plexin-B1 receptor complex.	RTKN PLXNB2	3.34e-04	13	73	2	19805522
Pubmed	The novel helicase helG (DHX30) is expressed during gastrulation in mice and has a structure similar to a human DExH box helicase.	NODAL DHX30	3.34e-04	13	73	2	25219788
Pubmed	A role for mel-18, a Polycomb group-related vertebrate gene, during theanteroposterior specification of the axial skeleton.	HOXB8 HOXC5	3.34e-04	13	73	2	8625838
Pubmed	PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.	EP400 MED14 PAGR1	3.53e-04	65	73	3	22496869
Pubmed	Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.	KMT2C CREBBP	3.89e-04	14	73	2	12482968
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	CNOT6 CCHCR1 SEC24B NINL GAN PPP1R13L RTKN ITGAV CREBBP DHX30	4.26e-04	1321	73	10	27173435
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	KMT2C EP400 MED14 XRCC5	4.31e-04	167	73	4	20362541
Pubmed	Differentially expressed genes in the testicular tissues of adenylyl cyclase 3 knockout mice.	DCC ITGAV	4.48e-04	15	73	2	27864010
Pubmed	Hox genes and the evolution of vertebrate axial morphology.	HOXB8 HOXC5	5.12e-04	16	73	2	7768176
Pubmed	H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.	KMT2C PAGR1	5.12e-04	16	73	2	24368734
Pubmed	MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.	KMT2C PAGR1	5.79e-04	17	73	2	26180087
Pubmed	Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns.	BUB1B CREBBP	5.79e-04	17	73	2	14519686
Pubmed	PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.	KMT2C PAGR1	6.51e-04	18	73	2	17500065
Pubmed	Global deficits in development, function, and gene expression in the endocrine pancreas in a deletion mouse model of Prader-Willi syndrome.	MAGEL2 CLTRN	6.51e-04	18	73	2	21343540
Pubmed	An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.	MED14 CREBBP	7.26e-04	19	73	2	16799563
Pubmed	Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription.	MED14 CREBBP	7.26e-04	19	73	2	16204234
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	SYNRG EP400 ARFGAP1 SEC24B BUB1B XRCC5 ACBD3 DHX30	7.56e-04	934	73	8	33916271
Pubmed	Secretory protein trafficking and organelle dynamics in living cells.	COPA ARFGAP1 SEC24B	7.74e-04	85	73	3	11031247
Pubmed	Human transcription factor protein interaction networks.	FHAD1 KMT2C EP400 COPA ARFGAP1 SEC24B PAGR1 XRCC5 CREBBP DHX30	7.83e-04	1429	73	10	35140242
Pubmed	The RepID-CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation.	BUB1B XRCC5	8.06e-04	20	73	2	31911655
Pubmed	The mouse PcG gene eed is required for Hox gene repression and extraembryonic development.	HOXB8 HOXC5	8.06e-04	20	73	2	12370779
Pubmed	Interaction network of human early embryonic transcription factors.	KMT2C HIVEP2 EP400 PAGR1 CREBBP	8.72e-04	351	73	5	38297188
Pubmed	Crypto-rhombomeres of the mouse medulla oblongata, defined by molecular and morphological features.	HOXB8 HOXC5	8.89e-04	21	73	2	25381007
Pubmed	Organization of human class I homeobox genes.	HOXB8 HOXC5	9.77e-04	22	73	2	2576652
Pubmed	Structural basis for activity regulation of MLL family methyltransferases.	KMT2C PAGR1	9.77e-04	22	73	2	26886794
Pubmed	Composite co-activator ARC mediates chromatin-directed transcriptional activation.	MED14 CREBBP	1.07e-03	23	73	2	10235267
Pubmed	F-box protein FBXL16 binds PP2A-B55α and regulates differentiation of embryonic stem cells along the FLK1+ lineage.	XRCC5 DHX30	1.07e-03	23	73	2	24390425
Pubmed	Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects.	HOXB8 HOXC5	1.16e-03	24	73	2	9367423
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SYNRG EP400 COPA ARFGAP1 MED14 PAGR1 SPICE1	1.20e-03	774	73	7	15302935
Pubmed	Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	KMT2C EP400 BEGAIN	1.35e-03	103	73	3	10819331
Pubmed	Fine mapping of human HOX gene clusters.	HOXB8 HOXC5	1.37e-03	26	73	2	8646877
Pubmed	Developmental origins for semilunar valve stenosis identified in mice harboring congenital heart disease-associated GATA4 mutation.	PAK6 CREBBP	1.37e-03	26	73	2	31138536
Pubmed	Functional proteomics mapping of a human signaling pathway.	MTMR11 PPP1R13L ACBD3 CREBBP SVEP1 DHX30	1.53e-03	591	73	6	15231748
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	CNOT6 COPA ARFGAP1 SEC24B POLRMT XRCC5 ITGAV PLXNB2 DHX30	1.54e-03	1297	73	9	33545068
Pubmed	Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.	BUB1B RNF38 CREBBP	1.63e-03	110	73	3	37219487
Cytoband	1p36.13	CPLANE2 PADI4 PADI2 PADI3	2.14e-06	56	74	4	1p36.13
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	MIIP CPLANE2 FHAD1 PADI4 ATP13A2 PADI2 PADI3	1.17e-04	681	74	7	chr1p36
GeneFamily	Peptidyl arginine deiminases	PADI4 PADI2 PADI3	1.54e-07	5	46	3	677
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_D2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CNOT6 MTMR11 HSPB6 TNS2 PAGR1	6.64e-06	158	74	5	74aa4f75307575ac3b2b1aa9f727753692f88742
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_D2\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	CNOT6 MTMR11 HSPB6 TNS2 PAGR1	7.28e-06	161	74	5	58381131e651744b5141b202f9d6063f55432db5
ToppCell	343B-Myeloid-Dendritic-pDC\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	CLTRN CECR2 LINC02901 RTKN SPICE1	9.21e-06	169	74	5	632aa3ab39ec87bafcefec6cddf71129a054d3b0
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CECR2 MROH2B HSPB6 NFASC SVEP1	1.32e-05	182	74	5	3dfa9187e9d2bab1d199079d29209c4648220ada
Disease	Squamous cell carcinoma of esophagus	CCHCR1 KMT2C BUB1B CREBBP	8.30e-05	95	71	4	C0279626
Disease	Colorectal Carcinoma	KMT2C ICAM5 BUB1B ADAM29 PAK6 DCC NODAL	1.49e-03	702	71	7	C0009402
Disease	Colorectal cancer	BUB1B DCC	1.93e-03	27	71	2	cv:C0346629
Disease	COLORECTAL CANCER	BUB1B DCC	1.93e-03	27	71	2	114500
Disease	Neoplasm of the large intestine	BUB1B DCC	1.93e-03	27	71	2	cv:C0009404
Disease	Sezary Syndrome	KMT2C CREBBP	1.93e-03	27	71	2	C0036920
Disease	interleukin 4 measurement	TRIB3 ADAM29	3.41e-03	36	71	2	EFO_0008184
Disease	Carcinoma, Transitional Cell	KMT2C CREBBP	4.41e-03	41	71	2	C0007138
Disease	colorectal cancer, endometrial neoplasm	FAM182A GDPD5	4.62e-03	42	71	2	EFO_0004230, MONDO_0005575

Protein segments in the cluster

Peptide	Gene	Start	Entry
TVQPWIAPPMPRAKE	BUB1B	291	O60566
QSQPWVMPSQSQPPV	ADAM29	731	Q9UKF5
MFPAGPPWPRVRVVQ	CATSPERG	6	Q6ZRH7
QTEVMPLWTPPTPPQ	EP400	2241	Q96L91
PGPQQALMPPNLWSL	BEGAIN	386	Q9BUH8
SLAVSNWPKPMPLIP	ABHD18	206	Q0P651
WQQAPLPQQQPMPGL	CREBBP	2021	Q92793
AQNWTPPQPRTLPSM	ARFGAP1	131	Q8N6T3
PEPTMPPTSWRQLNP	DHX30	156	Q7L2E3
QPWNEPPVILSMVIL	C3AR1	16	Q16581
SRVMRPPVPPNQWTE	CECR2	831	Q9BXF3
VPIVFQEPMWAPTPV	MSANTD5	156	A0A3B3IT52
DGQPWMPPPSEIQRL	PAGR1	101	Q9BTK6
PMPWNVPPDLSPRVV	KCNH3	811	Q9ULD8
PPWVKSPPLLMHQNR	ANKRD34B	246	A5PLL1
FRVAPWIMTPNTQPP	PADI4	291	Q9UM07
IIMSWTPPLNPNIVV	DCC	741	P43146
LSQPPAPPQIYPWMT	HOXC5	131	Q00444
KQMPWPEPQSPRVLP	PAK6	156	Q9NQU5
LPWGNVAVERNMPPL	KIAA0100	1066	Q14667
PVRMPSLPGWQPNSA	KMT2C	3326	Q8NEZ4
MEIPVPVQPSWLRRA	HSPB6	1	O14558
WQAPAVTWQVPPPMR	MAGEL2	396	Q9UJ55
LPAVPWVPQPNMNAS	MAGEL2	831	Q9UJ55
PDSWLPRPQPSFMVP	MTMR11	541	A4FU01
MQGIDRWIPSIPPLQ	FAM182A	1	Q5T1J6
VLMPSPRIWPQVTPT	KCNJ5-AS1	31	Q8TAV5
QPPLPDVLVWMLSGQ	FER1L4	656	A9Z1Z3
PPVSVPEMLGLQNRW	LINC02901	61	Q4VX62
QPWLLSLQPPDMSPV	CORO7	851	P57737
MVVIAEPLQSWQPPR	PLXNB2	1016	O15031
DRVELMPLPPWQPVG	ICAM5	121	Q9UMF0
MPLPPWQPVGENFTL	ICAM5	126	Q9UMF0
RAPGDPQLPVMVWFP	CES4A	126	Q5XG92
RQAPMSWMPVPPQAI	NSUN5P2	41	Q63ZY6
LSQVPSPLWIMPPDE	GDPD5	481	Q8WTR4
LPVIAAPSMWTRPQI	ACBD3	366	Q9H3P7
PWIMTPNILPPVSVF	PADI2	296	Q9Y2J8
FRVAPWIMTPSTLPP	PADI3	291	Q9ULW8
TNMPPPRKLPQRSWA	MED14	1156	O60244
EQSPSPTQLFPWMRP	HOXB8	126	P17481
MARQPPPPWVHAAFL	NFASC	1	O94856
MARPPVPGSVVVPNW	CPLANE2	1	Q9BU20
GTQVLAVMRPPLWEP	ATP13A2	596	Q9NQ11
PAPMQRSWSQAFPRP	FHAD1	141	B1AJZ9
KSWQVPPPAPEVQIR	BABAM1	71	Q9NWV8
QPPAPIMPLDTNWPL	COPA	796	P53621
PNRQLWIELAPLSMP	GAN	301	Q9H2C0
QPAPMPVPVWVIILA	ITGAV	986	P06756
RMAPTWLSDIPLVQP	CCHCR1	26	Q8TD31
PWMREIQISPSPKPH	FCHSD2	636	O94868
RNILPMTPVWAPVPN	SEC24B	531	O95487
ALREQPWPLPVQMEL	POLRMT	561	O00411
TLPRSWQPVSRIPMP	PPP1R13L	341	Q8WUF5
WQPVSRIPMPPSSPQ	PPP1R13L	346	Q8WUF5
TEQPPPRSWIMLQEP	CNOT6	166	Q9ULM6
PWLAMFTDQPALPNP	RTKN	481	Q9BST9
PWEMTSNRQPPSVRP	RNF38	86	Q9H0F5
SQDPAQPRMPPWIYN	SYNRG	281	Q9UMZ2
QPRMPPWIYNESLVP	SYNRG	286	Q9UMZ2
WPRPPTPPATNVLLM	NODAL	181	Q96S42
MLPPTPTWSVPQVPR	MIIP	366	Q5JXC2
PVKMPSPPWECNLLQ	PTTG2	166	Q9NZH5
MPQVLWPRILTFVVP	MROH2B	446	Q7Z745
SQTQPRMWEPPLRPA	NINL	951	Q9Y2I6
QWNPSPMSIQCIPVR	SVEP1	2131	Q4LDE5
PPMSPVQLPLRAWTE	SPICE1	761	Q8N0Z3
RDWLNMLSPPIVPPS	CFAP20DC	621	Q6ZVT6
TLAPPMDPSVPIWII	CLTRN	131	Q9HBJ8
LPLREMTAWINPPQI	PRY	71	O14603
MPEWPPCLSVAPALV	ZNF488	1	Q96MN9
PPAAKWQDRPMQPLV	IGSF9B	1116	Q9UPX0
LHPWLRQDPMPLAPT	TRIB3	311	Q96RU7
LVAPTPLRPWPQMTL	PPP1R3F	366	Q6ZSY5
PLRPWPQMTLQVSDV	PPP1R3F	371	Q6ZSY5
MLPAWIMIEPPVQPA	TECPR2	1251	O15040
ETPMVPPRRPWTLVN	AGPAT4	296	Q9NRZ5
PTVCMVHLPAQQPPW	HIVEP2	1211	P31629
PLTPVPSQMPWLVAS	TNS2	1031	Q63HR2
PSQMPWLVASPEPPQ	TNS2	1036	Q63HR2
PREPLPPIQQHIWNM	XRCC5	501	P13010