Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	NuRD complex binding	PWWP2B ZNF827	1.06e-05	3	38	2	GO:0120325
Domain	PH	CNKSR1 ELMO3 RAPH1 ARHGEF5 APBB1IP SOS2	2.22e-05	278	39	6	SM00233
Domain	PH_DOMAIN	CNKSR1 ELMO3 RAPH1 ARHGEF5 APBB1IP SOS2	2.27e-05	279	39	6	PS50003
Domain	PH_domain	CNKSR1 ELMO3 RAPH1 ARHGEF5 APBB1IP SOS2	2.32e-05	280	39	6	IPR001849
Domain	PH	CNKSR1 RAPH1 ARHGEF5 APBB1IP SOS2	1.09e-04	229	39	5	PF00169
Domain	-	CNKSR1 ELMO3 RAPH1 ARHGEF5 APBB1IP SOS2	1.47e-04	391	39	6	2.30.29.30
Domain	PH_dom-like	CNKSR1 ELMO3 RAPH1 ARHGEF5 APBB1IP SOS2	2.34e-04	426	39	6	IPR011993
Domain	RA	RAPH1 APBB1IP	1.90e-03	31	39	2	SM00314
Domain	RA	RAPH1 APBB1IP	2.56e-03	36	39	2	PF00788
Domain	RA	RAPH1 APBB1IP	2.70e-03	37	39	2	PS50200
Domain	GDS_CDC24_CS	ARHGEF5 SOS2	3.00e-03	39	39	2	IPR001331
Domain	RA_dom	RAPH1 APBB1IP	3.15e-03	40	39	2	IPR000159
Domain	DH_1	ARHGEF5 SOS2	7.66e-03	63	39	2	PS00741
Domain	RhoGEF	ARHGEF5 SOS2	8.87e-03	68	39	2	SM00325
Domain	SAM_1	CNKSR1 CASKIN1	8.87e-03	68	39	2	PF00536
Domain	DH_2	ARHGEF5 SOS2	9.38e-03	70	39	2	PS50010
Domain	RhoGEF	ARHGEF5 SOS2	9.38e-03	70	39	2	PF00621
Domain	DH-domain	ARHGEF5 SOS2	9.64e-03	71	39	2	IPR000219
Domain	-	ARHGEF5 SOS2	9.64e-03	71	39	2	1.20.900.10
Domain	SH3_2	ARHGEF5 CASKIN1	1.39e-02	86	39	2	IPR011511
Domain	SH3_2	ARHGEF5 CASKIN1	1.39e-02	86	39	2	PF07653
Domain	SAM	CNKSR1 CASKIN1	1.45e-02	88	39	2	SM00454
Pathway	REACTOME_LOSS_OF_MECP2_BINDING_ABILITY_TO_THE_NCOR_SMRT_COMPLEX	NCOR1 MECP2	5.80e-05	7	24	2	M27899
Pathway	REACTOME_LOSS_OF_FUNCTION_OF_MECP2_IN_RETT_SYNDROME	NCOR1 MECP2	2.14e-04	13	24	2	M29766
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	GLIS3 NKX2-5 NCOR1 TULP4 PHF23 ARHGEF5 MRTFA SON YLPM1 SOS2	3.47e-11	430	39	10	35044719
Pubmed	A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5.	NKX2-5 FBLIM1	1.23e-06	2	39	2	14757752
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	NCOR1 PWWP2B RAPH1 MECP2 PRRC2A MRTFA SON YLPM1	1.94e-06	774	39	8	15302935
Pubmed	A RIAM/lamellipodin-talin-integrin complex forms the tip of sticky fingers that guide cell migration.	RAPH1 APBB1IP	3.67e-06	3	39	2	26419705
Pubmed	The Ski protein family is required for MeCP2-mediated transcriptional repression.	NCOR1 MECP2	7.34e-06	4	39	2	11441023
Pubmed	Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis.	NCOR1 SON	7.34e-06	4	39	2	18952841
Pubmed	Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction.	NKX2-5 NCOR1	1.22e-05	5	39	2	29033129
Pubmed	PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins.	RAPH1 APBB1IP	1.22e-05	5	39	2	15642358
Pubmed	Structure of the MeCP2-TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders.	NCOR1 MECP2	1.83e-05	6	39	2	28348241
Pubmed	IL-2 can signal via chemokine receptors to promote regulatory T cells' suppressive function.	RAPH1 APBB1IP	1.83e-05	6	39	2	37598341
Pubmed	Direct Binding of Rap1 to Talin1 and to MRL Proteins Promotes Integrin Activation in CD4+ T Cells.	RAPH1 APBB1IP	1.83e-05	6	39	2	35197328
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	NCOR1 SNX15 PWWP2B MLXIP ZNF628 TULP4 ZNF827 CASKIN1	2.59e-05	1105	39	8	35748872
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	TULP4 N4BP2 CASKIN1 MRTFA	2.63e-05	153	39	4	10718198
Pubmed	Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation.	DZIP3 NCOR1	3.42e-05	8	39	2	18206970
Pubmed	Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor.	NCOR1 MECP2	3.42e-05	8	39	2	23770565
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	BCL9L ZFC3H1 RAPH1 PRRC2A SON	5.05e-05	361	39	5	26167880
Pubmed	FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands.	FMNL3 MECP2	5.48e-05	10	39	2	9171351
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DZIP3 CASC3 NCOR1 PRRC2A N4BP2 CASKIN1 YLPM1	8.66e-05	963	39	7	28671696
Pubmed	A hypomorphic lsd1 allele results in heart development defects in mice.	NKX2-5 FBLIM1	1.46e-04	16	39	2	23637775
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZNF526 KRBA1 ZFC3H1 TULP4 N4BP2	2.17e-04	493	39	5	15368895
Pubmed	Myocardin regulates BMP10 expression and is required for heart development.	NKX2-5 MRTFA	2.30e-04	20	39	2	22996691
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	NCOR1 CNKSR1 PRRC2A MRTFA SON	2.38e-04	503	39	5	16964243
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	GLIS3 NCOR1 KRBA1 FBLIM1 PHF23 MRTFA	2.62e-04	808	39	6	20412781
Pubmed	The functional interactome landscape of the human histone deacetylase family.	NCOR1 ZNF827 SON YLPM1	3.05e-04	289	39	4	23752268
Pubmed	HAND2-mediated epithelial maintenance and integrity in cardiac outflow tract morphogenesis.	NKX2-5 MRTFA	4.88e-04	29	39	2	31201155
Pubmed	Functional proteomics mapping of a human signaling pathway.	FMNL3 NCOR1 CNKSR1 SON YLPM1	4.98e-04	591	39	5	15231748
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	KPRP RAPH1 MECP2 PRRC2A ARHGEF5 SOS2	5.10e-04	916	39	6	32203420
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	BCL9L CASC3 PRRC2A SON	5.15e-04	332	39	4	37433992
Pubmed	Transferrin Receptor Protein 1 Cooperates with mGluR2 To Mediate the Internalization of Rabies Virus and SARS-CoV-2.	GAPDHS ZFC3H1 PRRC2A SON	5.21e-04	333	39	4	36779763
Pubmed	Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes.	APBB1IP YLPM1	5.58e-04	31	39	2	19041431
Pubmed	miR-218 Promotes Dopaminergic Differentiation and Controls Neuron Excitability and Neurotransmitter Release through the Regulation of a Synaptic-Related Genes Network.	MECP2 CASKIN1	5.58e-04	31	39	2	37816598
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	RAB12 MECP2 PRRC2A CASKIN1	6.08e-04	347	39	4	17114649
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	NKX2-5 NCOR1 MECP2 PRRC2A SON YLPM1	6.31e-04	954	39	6	36373674
Pubmed	Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.	RAB12 DENND4B	7.96e-04	37	39	2	20937701
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	NCOR1 ZFC3H1 RAPH1 MECP2 N4BP2 SPEF2 YLPM1	9.96e-04	1442	39	7	35575683
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	BCL9L NCOR1 YLPM1	1.09e-03	180	39	3	35198878
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DZIP3 MLXIP DENND4B SON	1.10e-03	407	39	4	12693553
Interaction	NCK2 interactions	KPRP ZNF526 RAPH1 GGN PRRC2A YLPM1	1.04e-05	262	39	6	int:NCK2
Interaction	GRB2 interactions	KPRP NKX2-5 CASC3 ELMO3 GGN PRRC2A ARHGEF5 YLPM1 SOS2	1.80e-05	806	39	9	int:GRB2
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	CNKSR1 RAPH1 APBB1IP SOS2	2.70e-04	206	28	4	682
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	DZIP3 NCOR1 YLPM1	2.69e-03	181	28	3	694
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF5 SOS2	4.67e-03	66	28	2	722
GeneFamily	Sterile alpha motif domain containing	CNKSR1 CASKIN1	8.15e-03	88	28	2	760
Coexpression	GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN	BCL9L NCOR1 MLXIP PHF23 MRTFA	1.15e-05	200	39	5	M5851
Coexpression	GSE13946_CTRL_VS_DSS_COLITIS_GD_TCELL_FROM_COLON_DN	TULP4 N4BP2 SON YLPM1	1.18e-04	170	39	4	M2942
Coexpression	GSE40493_BCL6_KO_VS_WT_TREG_UP	ZFC3H1 TULP4 N4BP2 SOS2	1.37e-04	177	39	4	M9401
Coexpression	SENESE_HDAC3_TARGETS_DN	BCL9L CASC3 MLXIP RAPH1 MECP2 N4BP2	1.47e-04	548	39	6	M16859
Coexpression	GSE37534_UNTREATED_VS_PIOGLITAZONE_TREATED_CD4_TCELL_PPARG1_AND_FOXP3_TRASDUCED_UP	DZIP3 TULP4 MECP2 SOS2	2.07e-04	197	39	4	M8980
Coexpression	GSE21927_C26GM_VS_4T1_TUMOR_MONOCYTE_BALBC_DN	CASC3 ZFC3H1 APBB1IP SON	2.15e-04	199	39	4	M7607
Coexpression	GSE15330_HSC_VS_GRANULOCYTE_MONOCYTE_PROGENITOR_UP	NCOR1 KRBA1 ELMO3 PRRC2A	2.20e-04	200	39	4	M7060
Coexpression	GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_UP	NCOR1 GAPDHS MECP2 APBB1IP	2.20e-04	200	39	4	M3901
Coexpression	GSE7764_IL15_TREATED_VS_CTRL_NK_CELL_24H_DN	RAB12 KRBA1 TULP4 APBB1IP	2.20e-04	200	39	4	M5724
Coexpression	GSE5542_IFNG_VS_IFNA_AND_IFNG_TREATED_EPITHELIAL_CELLS_24H_UP	FMNL3 PWWP2B MRTFA SON	2.20e-04	200	39	4	M6535
Coexpression	GSE43956_WT_VS_SGK1_KO_TH17_DIFFERENTIATED_CD4_TCELL_DN	GAPDHS TULP4 APBB1IP SOS2	2.20e-04	200	39	4	M9628
Disease	lymphocyte count	DZIP3 GLIS3 NKX2-5 NCOR1 RAPH1 PHF23 SPEF2 APBB1IP MRTFA	9.75e-05	1464	39	9	EFO_0004587
Disease	psoriasis	RAB12 KPRP MLXIP SON	4.57e-04	273	39	4	EFO_0000676
Disease	Mental Retardation, Psychosocial	CNKSR1 ZNF526 MECP2	8.26e-04	139	39	3	C0025363
Disease	Profound Mental Retardation	CNKSR1 ZNF526 MECP2	8.26e-04	139	39	3	C0020796
Disease	Mental deficiency	CNKSR1 ZNF526 MECP2	8.26e-04	139	39	3	C0917816
Disease	systolic blood pressure change measurement	KRBA1 GAPDHS	1.77e-03	47	39	2	EFO_0006944
Disease	susceptibility to common cold measurement	SPEF2 MRTFA	2.33e-03	54	39	2	EFO_0008417
Disease	Malignant neoplasm of breast	BOC NCOR1 RAPH1 PRRC2A N4BP2 RPS6KB2	2.68e-03	1074	39	6	C0006142
Disease	forced expiratory volume	GLIS3 BOC NCOR1 ZNF628 TULP4	3.66e-03	789	39	5	EFO_0004314
Disease	congenital heart disease (implicated_via_orthology)	NKX2-5 SON	3.78e-03	69	39	2	DOID:1682 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
PLPIIDPPTEPPPLP	ARHGEF5	841	Q12774
PPADPVLDLPLPPPP	APBB1IP	131	Q7Z5R6
PEPEIPPELPPPRPH	RAB12	226	Q6IQ22
PPPETELPLPPIEIP	RAPH1	1076	Q70E73
LPPPPPPAEPPPTDL	CASKIN1	1191	Q8WXD9
PPELPPPEAAPPVLP	KRBA1	771	A5PL33
ELPPLPPPTPPPTLQ	GGN	436	Q86UU5
TLELVGLPPPPPPPA	NKX2-5	201	P52952
LPPVQLPPPPPSPEI	DZIP3	946	Q86Y13
PAPPPISPVLPLVPP	MLXIP	441	Q9HAP2
LPPPTLAPPQPPLPE	BOC	821	Q9BWV1
PPPEGLIPAPPVPET	CASC3	426	O15234
PPEEVLPLPPPPAPP	FMNL3	511	Q8IVF7
VDLPPAPPLPPLPPP	GLIS3	286	Q8NEA6
ELLPDRPLLPPPPPP	BCL9L	1116	Q86UU0
ENVPIPERPPPVPPP	ELMO3	691	Q96BJ8
IPPPELPPDLPPPAR	DENND4B	1076	O75064
LDLLPPPPPPPPVLL	FBLIM1	101	Q8WUP2
PPPPPPPVLLPSEEE	FBLIM1	106	Q8WUP2
PEPIPLPAPCPSPEP	KPRP	476	Q5T749
PVREEIKPPPPPLPP	GAPDHS	46	O14556
TTRPEPPPPLVPPLP	PWWP2B	96	Q6NUJ5
PLLPPLPPPPPEPES	MECP2	381	P51608
LAELPLPTPPPAPPP	SPEF2	906	Q9C093
PLPDTPPPVPLRPPE	SOS2	1211	Q07890
EPTELPLPPLLPPPP	RPS6KB2	441	Q9UBS0
EPPPPLPPPPEPIST	NCOR1	606	O75376
PPEEVPPPTTPPVPK	PRRC2A	601	P48634
LAEQPPLPPPPLLPP	MRTFA	176	Q969V6
GPEPLPIPPEPPAIL	CNKSR1	346	Q969H4
PPPLPPPQPPVDVCL	TULP4	851	Q9NRJ4
LPPPLIPTPPPDDPR	SNX15	141	Q9NRS6
PVPVLPTPPEAPRPP	PHF23	271	Q9BUL5
PPLPPPNEEVPPPLP	YLPM1	351	P49750
PPPPPPPPQSLELLL	ZNF827	336	Q17R98
ATVAEPPVPPPLPPP	ZNF526	166	Q8TF50
SLEPLPPLPPLPPLP	ZFC3H1	591	O60293
PPLPPLPPLPPEDPE	ZFC3H1	596	O60293
VPPLPPEEPPTMPPL	SON	1146	P18583
PPPPPPPVVPELFLA	ZNF628	271	Q5EBL2
VLAPLPLLLPPPPPP	N4BP2	346	Q86UW6