Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentmitochondrial large ribosomal subunit

MRPL39 MRPL57 MRPL34

9.90e-0557333GO:0005762
GeneOntologyCellularComponentorganellar large ribosomal subunit

MRPL39 MRPL57 MRPL34

9.90e-0557333GO:0000315
GeneOntologyCellularComponentmitochondrial ribosome

MRPL39 MRPL57 MRPL34

3.96e-0491333GO:0005761
GeneOntologyCellularComponentorganellar ribosome

MRPL39 MRPL57 MRPL34

3.96e-0491333GO:0000313
GeneOntologyCellularComponentlarge ribosomal subunit

MRPL39 MRPL57 MRPL34

8.45e-04118333GO:0015934
GeneOntologyCellularComponentmitochondrial membrane

MRPL39 ANTKMT MRPL57 MRPL34 COQ2 CYP27B1

2.11e-03866336GO:0031966
GeneOntologyCellularComponentmitochondrial envelope

MRPL39 ANTKMT MRPL57 MRPL34 COQ2 CYP27B1

2.73e-03912336GO:0005740
GeneOntologyCellularComponentribosomal subunit

MRPL39 MRPL57 MRPL34

3.50e-03194333GO:0044391
HumanPhenoAbnormality of the liver

PEX16 STIM1 MRPL39 TGFBR2 COMT COQ2 ALG1 CYP27B1 PKD1 DUOXA2

2.18e-0512051210HP:0001392
MousePhenodecreased Ly6C low monocyte number

STIM1 DUOXA2

4.59e-056252MP:0013026
MousePhenoaortic dissection

TGFBR2 PKD1

1.10e-049252MP:0004044
MousePhenomyelofibrosis

STIM1 MPIG6B

1.37e-0410252MP:0011747
MousePhenoabnormal NK cell number

STIM1 PARVB COMT DUOXA2

2.29e-04172254MP:0008043
MousePhenoaortic aneurysm

TGFBR2 PKD1

2.76e-0414252MP:0006278
MousePhenoabnormal Ly6C low monocyte number

STIM1 DUOXA2

2.76e-0414252MP:0013024
MousePhenoabnormal NK cell morphology

STIM1 PARVB COMT DUOXA2

2.90e-04183254MP:0005068
MousePhenodecreased myeloid cell number

STIM1 COMT MPIG6B PTPN18 PKD1 DUOXA2

3.97e-04567256MP:0013662
MousePhenoabnormal radius morphology

CYP27B1 PKD1 DUOXA2

4.08e-0482253MP:0000552
MousePhenoabnormal ulna morphology

CYP27B1 PKD1 DUOXA2

4.38e-0484253MP:0005108
DomainPKD

TMEM130 PKD1

1.55e-0411322PS50093
DomainPKD_dom

TMEM130 PKD1

1.55e-0411322IPR000601
Domain-

TMEM130 PKD1

1.55e-04113222.60.40.670
Pubmed

Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1.

STIM1 PKD1

8.73e-07233220808796
Pubmed

Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100.

TGFBR2 PARVB

1.31e-05633225117820
Pubmed

Structures of the human mitochondrial ribosome in native states of assembly.

MRPL39 MRPL57 MRPL34

1.67e-055233328892042
Pubmed

Structure of the large ribosomal subunit from human mitochondria.

MRPL39 MRPL57 MRPL34

1.67e-055233325278503
Pubmed

The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.

MRPL39 MRPL57 MRPL34

2.32e-055833311543634
Pubmed

Expression analysis of mammalian mitochondrial ribosomal protein genes.

MRPL39 MRPL57 MRPL34

5.86e-057933332987154
Pubmed

Structure and Function of the Mitochondrial Ribosome.

MRPL39 MRPL57 MRPL34

6.55e-058233327023846
Pubmed

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

MRPL39 MRPL57 MRPL34 COMT COQ2 CYP27B1

2.10e-0492633620877624
Pubmed

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

DHRS13 TMEM130 FGF19 XKR5 ALG1 ELAPOR1

2.93e-0498533612975309
Pubmed

Global analysis of gene expression in the developing brain of Gtf2ird1 knockout mice.

COQ2 FGF19

3.49e-042933221909369
Pubmed

Heritable Thoracic Aortic Disease Overview

TGFBR2 PKD1

3.74e-043033220301299
Pubmed

A mitochondrial protein compendium elucidates complex I disease biology.

MRPL39 MRPL57 MRPL34 COMT COQ2 CYP27B1

4.05e-04104733618614015
Pubmed

Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection.

TGFBR2 MMP24

5.39e-043633220587546
Pubmed

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

MRPL39 ANTKMT MRPL57 MRPL34 COQ2 CYP27B1

6.23e-04113633634800366
Pubmed

Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.

MRPL39 MRPL57 MRPL34

6.85e-0418233312706105
Cytoband16p13.3

ANTKMT ALG1 PKD1

7.19e-0424433316p13.3
GeneFamilyMitochondrial ribosomal proteins

MRPL39 MRPL57 MRPL34

1.34e-0479233646
ToppCellBasal_cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

ABCA13 SDK1 PKD1 ELAPOR1

8.10e-06174334a0060be3940043015dcc49a5157de5541aed24a1
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2-Slc17a8.Synpr-Sncg-Yjefn3_(Neuron.Gad1Gad2-Slc17a8.Synpr-Sncg-Yjefn3)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

FGF19 XKR5 TAT

1.67e-0567333e53dfc288c943656a0b064afe593ea2101d75437
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2-Slc17a8.Synpr-Sncg-Yjefn3_(Neuron.Gad1Gad2-Slc17a8.Synpr-Sncg-Yjefn3)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

FGF19 XKR5 TAT

1.67e-05673331841cee311a4b1b802c9e872793435afb730592f
Diseaseprotein FAM3D measurement

NTN5 SLC2A6

7.47e-0512322EFO_0021869
Diseasecumulative dose response to bevacizumab

TGFBR2 PARVB

1.93e-0419322EFO_0005944
Diseasehypertrophic cardiomyopathy (implicated_via_orthology)

STIM1 PKD1

4.54e-0429322DOID:11984 (implicated_via_orthology)
Diseasefrontal fibrosing alopecia

TGFBR2 SDK1

1.25e-0348322EFO_0009855
DiseaseFamilial thoracic aortic aneurysm and aortic dissection

TGFBR2 PKD1

1.52e-0353322C4707243
Diseasepancreatic ductal carcinoma (is_marker_for)

TGFBR2 MUC3A

2.00e-0361322DOID:3587 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
GPLPHTLLDFWRLVW

PTPN18

106

Q99952
PLLLLGGWKRWRRGR

ALG1

16

Q9BT22
LRVLLHWDLLRWPRG

ABCA13

4671

Q86UQ4
LNPWLVALARLHAWR

ANTKMT

106

Q9BQD7
WLRHLVPGPWGRLCR

CYP27B1

241

O15528
WSRWRVPGRLLLLLL

MMP24

26

Q9Y5R2
RGLRALALAWLPGWR

COQ2

11

Q96H96
RWLVPGWRLGWILIH

TAT

281

P17735
RIPRLWRLLLWAGTA

ELAPOR1

21

Q6UXG2
LLLALGVRAVRSGWW

MUC3A

3241

Q02505
WLRALGPWLRVRRGL

PEAK3

416

Q6ZS72
WILAGLWLAVAGRPL

FGF19

11

O95750
ALGLLLPWRWLAVAG

SLC2A6

186

Q9UGQ3
VHDLLRPRGWALRWS

PARVB

156

Q9HBI1
WGRPRLAGLLCLAVW

P2RY4

146

P51582
VLLLLLRHWGWGLCL

COMT

21

P21964
ILPGIRGHSRWFWLV

DUOXA2

41

Q1HG44
RGWWALLALQLHLLR

SDK1

81

Q7Z5N4
GWLRPLLRPLAWLVL

DHRS13

241

Q6UX07
LCVGLWALRLWGALR

PKD1

4086

P98161
WALRLWGALRLGAVI

PKD1

4091

P98161
HLLSLGLWGQRSWKP

PEX16

231

Q9Y5Y5
LLWRGRIPGRQWIGK

MRPL57

6

Q9BQC6
LRLWLVAPGGGIKWR

MRPL39

11

Q9NYK5
RWHRRLPGLWAAALL

SUSD5

11

O60279
LDRHGLALPWRPRWA

NTN5

446

Q8WTR8
LGALGLVWWLHRRLP

MPIG6B

156

O95866
LRGLWPLHIVLWTRI

TGFBR2

6

P37173
RLALWLLWGLLLHQG

STIM1

6

Q13586
RAIGWRLFLLLWHPA

TUG1

21

A0A6I8PU40
GSRGLLAWLLLLQPW

PRSS42P

6

Q7Z5A4
AALLGGRWLQPRAWL

MRPL34

16

Q9BQ48
WSRLGRILWLACLLP

TMEM130

6

Q8N3G9
GRLLWGWLALAVLLP

XKR5

31

Q6UX68
PSGRLLLSLHWDWGR

nan

51

Q6ZPA2