Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainK_chnl_volt-dep_Kv6

KCNG2 KCNG1

3.68e-053662IPR003969
DomainSAC3/GANP/THP3

MCM3AP PSMD8

7.35e-054662IPR005062
DomainSAC3_GANP

MCM3AP PSMD8

7.35e-054662PF03399
DomainSOCS_box

ASB18 ASB16 SPSB1

3.25e-0438663PF07525
DomainSOCS_box

ASB18 ASB16 SPSB1

3.52e-0439663SM00969
DomainSOCS

ASB18 ASB16 SPSB1

3.52e-0439663PS50225
DomainSOCS_box

ASB18 ASB16 SPSB1

3.52e-0439663IPR001496
DomainK_chnl_volt-dep_Kv

KCNG2 KCNG1

4.08e-0327662IPR003968
DomainDEATH

TRADD DAPK1

4.08e-0327662SM00005
DomainDeath

TRADD DAPK1

6.05e-0333662PF00531
DomainVG_K_chnl

KCNG2 KCNG1

6.05e-0333662IPR028325
DomainAnk_2

ASB18 ASB16 DAPK1 ANKRD63

7.05e-03215664PF12796
DomainDeath_domain

TRADD DAPK1

7.97e-0338662IPR000488
DomainDEATH_DOMAIN

TRADD DAPK1

7.97e-0338662PS50017
Pubmed

The SOCS box: a tale of destruction and degradation.

ASB18 ASB16 SPSB1 LRRC41

1.52e-064171412076535
Pubmed

Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

P3H1 FAM210B DLL3 TP53I13 PTGFRN MFSD5 SLC2A11

2.83e-0543071716303743
Pubmed

Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures.

TRADD DAPK1

1.14e-04871212911633
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

ASB18 SETX KCNG1 P3H1 MCM3AP INTS1 EXOSC3 CSMD2

1.27e-0473671829676528
Pubmed

Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.

INTS2 INTS1 PSMD8

1.88e-045471316239144
Pubmed

Structure of the catalytic core of the Integrator complex.

INTS2 INTS1

3.68e-041471233548203
Pubmed

The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts.

INTS2 INTS1

3.68e-041471232697989
Pubmed

INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module.

INTS2 INTS1

3.68e-041471232647223
Pubmed

Structural and functional insights into the B30.2/SPRY domain.

SPSB1 LRRC41

3.68e-041471216498413
Pubmed

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.

ESYT2 OXA1L INTS2 P3H1 TIMM50 PSMD8 TFB2M

3.88e-0465771736180527
Pubmed

ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes.

ASB18 ASB16

5.48e-041771216325183
Pubmed

Comparative analysis of apoptosis and inflammation genes of mice and humans.

BCL2L12 TRADD DAPK1

5.98e-048071312819136
Pubmed

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.

SPSB1 LRRC41

6.16e-041871215601820
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

ESYT2 OXA1L FLYWCH1 INTS2 PHLDA1 INTS1 HAGH LTF PTGFRN

7.47e-04120371929180619
Pubmed

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.

INTS2 INTS1

1.20e-032571234004147
Pubmed

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.

ESYT2 MCM3AP INTS1

1.28e-0310471331240132
Pubmed

Elongin A regulates transcription in vivo through enhanced RNA polymerase processivity.

INTS2 INTS1

1.29e-032671233298525
Pubmed

Array MAPPIT: high-throughput interactome analysis in mammalian cells.

SPSB1 FBXL2

1.29e-032671219159283
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

CELSR1 KCNG1 MCM3AP INTS1 TP53I13 ARRDC2 MFSD5 ABCC10

1.83e-03110571835748872
Pubmed

Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo.

DAPK1 PSMD8 TSR3 EPHA1 LRRC41

1.92e-034327157671812
Cytoband16p13.3

FLYWCH1 PRSS41 TEDC2 HAGH TSR3

3.98e-0524471516p13.3
CytobandEnsembl 112 genes in cytogenetic band chr16p13

FLYWCH1 PRSS41 TEDC2 HAGH TSR3

5.29e-04426715chr16p13
Cytoband18q23

KCNG2 PARD6G

9.32e-042971218q23
CytobandEnsembl 112 genes in cytogenetic band chr18q23

KCNG2 PARD6G

1.77e-0340712chr18q23
Cytoband11q13.2

RIN1 NUDT8

2.44e-034771211q13.2
CytobandEnsembl 112 genes in cytogenetic band chr19q13

BCL2L12 FKRP DLL3 TIMM50 PSMD8 EXOC3L2 LILRA4

2.45e-031192717chr19q13
Cytoband1p34.1

P3H1 LRRC41

3.56e-03577121p34.1
GeneFamilyIntegrator complex

INTS2 INTS1

6.51e-04154621366
GeneFamilyAnkyrin repeat domain containing

ASB18 ASB16 DAPK1 ANKRD63

3.29e-03242464403
GeneFamilyPotassium voltage-gated channels

KCNG2 KCNG1

4.64e-0340462274
ToppCell356C-Lymphocytic-ILC-ILC-3|356C / Donor, Lineage, Cell class and subclass (all cells)

PHLDA1 KCNG1 DLL3 LAG3 FXYD2 MIEF2

1.74e-07154716923f5eb8e9258105dbdbe57a5e7976ef60dae29b
ToppCell356C-Lymphocytic-ILC-ILC-3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PHLDA1 KCNG1 DLL3 LAG3 FXYD2 MIEF2

2.43e-071637162dbdcbc4c187aad3db837d191cc78662a75dd0b5
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM210B LRRC26 DEFB129 ANKRD63 TRIM14 FXYD2

3.69e-071757160992de1c7bffcb6890584357a7a0a8955927da6c
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

BCL2L12 KCNG1 ASB16 NUDT8 FXYD2

4.63e-061537150727dc70e16345645063c586d744bc4ac1710526
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Apold1_(Pi16)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

LTF EXOC3L2 TRIM14 GASK1B

8.22e-06807148713818f57f40c07268f791b45c8af6d522c628f
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Apold1_(Pi16)--|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

LTF EXOC3L2 TRIM14 GASK1B

8.22e-0680714475e1595528aef08799f099d7dc54412eaa14742
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Apold1_(Pi16)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

LTF EXOC3L2 TRIM14 GASK1B

8.22e-068071409baf1f1a4f07369af3696bc15d0ffcf89de984e
ToppCell356C-Lymphocytic-ILC|356C / Donor, Lineage, Cell class and subclass (all cells)

PHLDA1 LAG3 PARD6G FXYD2 EPHA1

8.89e-061757157fa8330ce813c48bd332be618909e5ec8d0f5d7e
ToppCell356C-Lymphocytic-ILC|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PHLDA1 LAG3 PARD6G FXYD2 EPHA1

9.40e-061777157ddd7d1854ad42abd630ad0c702105102cec93e7
ToppCell356C-Lymphocytic-ILC-ILC-1|356C / Donor, Lineage, Cell class and subclass (all cells)

PHLDA1 LAG3 PARD6G FXYD2 EPHA1

9.66e-0617871540df4bb0978e5e5568c52ad4a5881ea0cdc6941d
ToppCell356C-Lymphocytic-ILC-ILC-1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PHLDA1 LAG3 PARD6G FXYD2 EPHA1

1.02e-05180715cedbe692c5257fb6f9a552e2f197163626ac17d9
ToppCellwk_15-18-Epithelial-Distal_epithelial_progenitor-epi-tip_intermediate|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

TTC39B CELSR1 KIF12 C20orf204 EPHA1

1.16e-05185715636505a3d96f75d951ab42bcf8af6ae07abc732d
ToppCell368C-Endothelial_cells-Endothelial-F_(Lymphatics)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SPSB1 PARD6G FBXL2 PTGFRN ABCC10

1.39e-05192715b016e229300c183e14c0e2bba494bf49c7899112
ToppCell368C-Endothelial_cells-Endothelial-F_(Lymphatics)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SPSB1 PARD6G FBXL2 PTGFRN ABCC10

1.39e-05192715ac96831492c62ad9e1f7d0b764fbdf7d8a189ad9
ToppCellSepsis-Int-URO-Lymphocyte-T/NK-Treg|Int-URO / Disease, condition lineage and cell class

CCR10 METTL24 OTOF SPSB1 PARD6G

1.69e-0520071547f265336bc3b8052c0cac730ac9afd41cd8fc43
DrugQuinethazone [73-49-4]; Down 200; 13.8uM; PC3; HT_HG-U133A

TRADD SETX PHLDA1 ESRRA SIRT6 SLC1A7 EPHA1

2.81e-061987173793_DN

Protein segments in the cluster

PeptideGeneStartEntry
VRPLLRGRLRCSSAR

EXOC3L2

236

Q2M3D2
RSRGLKALRLCRALA

ESYT2

151

A0FGR8
LNVERCSLGRLTRRG

EPHA1

166

P21709
SLKCGLLRSFFRRRR

DAPK1

706

P53355
RFRQDLRRLLRGGSC

CCR10

316

P46092
LEGTARITCLGGRRR

CSMD2

1071

Q7Z408
RRGGRRQLLLRALDA

C20orf204

156

A0A1B0GTL2
RLAVRARLGSRCRQG

ASB16

416

Q96NS5
LSRLRRCLPCSLGRG

BCL2L12

131

Q9HB09
GGSVRLRLLCALRRA

CELSR1

176

Q9NYQ6
LRLLCALRRAAGAVR

CELSR1

181

Q9NYQ6
SLLARVAGRRRLAAG

DLL3

141

Q9NYJ7
AARVGALRLRARGRA

ARRDC2

41

Q8TBH0
RRLGLRLDRTNRAGL

ANKRD63

141

C9JTQ0
RGRLCRRGCVQALAL

TP53I13

161

Q8NBR0
ELRCRRLLAGATARL

NUDT8

11

Q8WV74
GGLLRRAACLRRCLG

P3H1

111

Q32P28
LGARVEACRARELGR

ABCC10

481

Q5T3U5
ALVRGCRGLKALLLR

FBXL2

176

Q9UKC9
LRCASRLGLGRFTLI

LILRA4

141

P59901
GRRLSDVRGGLLRLA

INTS1

1491

Q8N201
TNRLPGGRSRVLLRC

GPIHBP1

51

Q8IV16
AELGCRGRAITRGLR

FLYWCH1

151

Q4VC44
RSLAALGAACARRGL

HAGH

11

Q16775
RACGVRRLGELALRG

KIF12

81

Q96FN5
RCLRLCALLLRRGAE

ASB18

271

Q6ZVZ8
HAGRLGISCTRLRRL

MCM3AP

1301

O60318
LGLRSLGLTMRRCAR

KCNG2

306

Q9UJ96
LDARLLRTARGDCRG

FAM210B

46

Q96KR6
LGGRRRTDALRFLCK

INTS2

241

Q9H0H0
LGLTARRCTREFGLL

KCNG1

366

Q9UIX4
RALSCRLRLRLGQAS

LAG3

156

P18627
LLRVCRALLRAGVRG

AP5B1

576

Q2VPB7
MCGRRELLRLLQSGR

OXA1L

6

Q15070
LGAGSLCRRRRALGA

PARD6G

106

Q9BYG4
SLRLRRRHRCGGSLL

PRSS41

71

Q7RTY9
RPRTRRNLLLGTACA

GASK1B

31

Q6UWH4
RCGRGLALGRELLRL

GRID2IP

106

A4D2P6
CLAALRRLRGSGDLA

SLC2A11

226

Q9BYW1
ILARGRDVCRRNGLL

SLC1A7

6

O00341
GRLCSTLRRGLGLQR

CROCC2

1291

H7BZ55
FIGLRRCLMGLGRCR

DEFB129

21

Q9H1M3
SGGRARGRCVRLAKR

ERCC6L2-AS1

46

Q8WZB0
GLLILLSRRFRCGGN

FXYD2

41

P54710
GRARRAALLRALGIR

FKRP

261

Q9H9S5
GGAERRRAGRLLLTL

ESRRA

371

P11474
LRRCGDRLLVTKCGR

EXOSC3

71

Q9NQT5
CAGGLRCLLSDRRVL

MFSD5

236

Q6N075
RRRCLSERKRLGIGQ

LARP1B

716

Q659C4
RLLRRCRVLCNGGSS

OTOF

1246

Q9HC10
GTRRRLLLLLCAVCR

MIEF2

351

Q96C03
AVLLFGLRLCAELRR

METTL24

21

Q5JXM2
LALLSLALCRGRVVR

PTGFRN

11

Q9P2B2
RLRRRLAADGSLGRL

RIN1

451

Q13671
LGALGLCLAGRRRSV

LTF

11

P02788
RKVGRSLQRGCRALR

TRADD

231

Q15628
EAGRLRKACSLLRLR

TEDC2

266

Q7L2K0
LRALSGQAGCRLRAL

LRRC41

511

Q15345
LDELSRQRALCRGGR

SETX

2091

Q7Z333
RLRLSALAGAGRFCI

TFB2M

11

Q9H5Q4
ARGLRACRGELRDTI

SIRT6

171

Q8N6T7
LRSGLRLGSRGLCTR

TIMM50

11

Q3ZCQ8
ACRLRGRGNRVAALR

TTC39B

6

Q5VTQ0
CRRSVRLALGRERLG

SPSB1

241

Q96BD6
LLRVSLLCALRAGGR

PHLDA1

91

Q8WV24
ALLADALCRHRRLRG

MARS2

66

Q96GW9
LVSILAGCLLNRRRA

IGSF9

751

Q9P2J2
RLSADRLTVRCGLLG

TRIM14

281

Q14142
VCRRRCRKSGGLLAA

PSMD8

46

P48556
RRCTGRKLARLGLVR

TSR3

71

Q9UJK0
RKLARLGLVRCLRLG

TSR3

76

Q9UJK0
LALGSGLTACRARRR

LRRC26

281

Q2I0M4
RDNAVRLLSLRGCRL

LRRC73

26

Q5JTD7