Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionpyruvate kinase activity

PKLR PKM

2.74e-0521052GO:0004743
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

DHRS4L2 DHRS4 DLD ALDH7A1

1.18e-04481054GO:0016620
GeneOntologyMolecularFunctionBAT3 complex binding

USP13 VCP

1.63e-0441052GO:1904288
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors

DHRS4L2 DHRS4 DLD ALDH7A1

2.15e-04561054GO:0016903
GeneOntologyMolecularFunctionligase activity

UBA5 IARS1 PFAS ACSL3 CTPS2 RTCA

3.17e-041741056GO:0016874
GeneOntologyBiologicalProcesstranslesion synthesis

POLD1 USP43 POLI VCP

9.03e-06261064GO:0019985
GeneOntologyCellularComponentinsulin-responsive compartment

MYO5A LRP1 AKT2

1.97e-05111053GO:0032593
GeneOntologyCellularComponentpyruvate kinase complex

PKLR PKM

2.50e-0521052GO:1902912
GeneOntologyCellularComponentCKM complex

CDK8 CDK19

2.47e-0451052GO:1990508
Domain-

PKLR PKM

3.07e-05210423.40.1380.20
DomainPYRUVATE_KINASE

PKLR PKM

3.07e-0521042PS00110
DomainPyrv_Knase_insert_dom

PKLR PKM

3.07e-0521042IPR015806
DomainPK

PKLR PKM

3.07e-0521042PF00224
DomainPK_C

PKLR PKM

3.07e-0521042PF02887
Domain-

PKLR PKM

3.07e-05210422.40.33.10
DomainPyrv_Knase_AS

PKLR PKM

3.07e-0521042IPR018209
DomainPyrv_Knase_brl

PKLR PKM

3.07e-0521042IPR015793
DomainPyrv_Knase_a/b

PKLR PKM

3.07e-0521042IPR015794
DomainPyrv_Knase_C

PKLR PKM

3.07e-0521042IPR015795
DomainPyr_Knase

PKLR PKM

9.18e-0531042IPR001697
DomainPyrv/PenolPyrv_Kinase-like_dom

PKLR PKM

9.18e-0531042IPR015813
Domain-

PKLR PKM

9.18e-05310423.20.20.60
DomainPyrv_Knase-like_insert_dom

PKLR PKM

3.04e-0451042IPR011037
DomainRIH_assoc-dom

RYR3 ITPR1

4.54e-0461042IPR013662
DomainGATASE_TYPE_1

PFAS CTPS2

4.54e-0461042PS51273
DomainIns145_P3_rec

RYR3 ITPR1

4.54e-0461042PF08709
DomainGATASE

PFAS CTPS2

4.54e-0461042IPR017926
DomainRIH_assoc

RYR3 ITPR1

4.54e-0461042PF08454
DomainRIH_dom

RYR3 ITPR1

4.54e-0461042IPR000699
DomainIns145_P3_rcpt

RYR3 ITPR1

4.54e-0461042IPR014821
DomainRyanodine_recept-rel

RYR3 ITPR1

4.54e-0461042IPR015925
Domain-

RYR3 ITPR1

4.54e-04610421.25.10.30
DomainRYDR_ITPR

RYR3 ITPR1

4.54e-0461042PF01365
DomainPH-BEACH_dom

NBEAL1 NSMAF

8.41e-0481042IPR023362
Domain-

NBEAL1 NSMAF

8.41e-04810422.30.29.40
DomainPH_BEACH

NBEAL1 NSMAF

8.41e-0481042PS51783
DomainBEACH

NBEAL1 NSMAF

1.08e-0391042PS50197
DomainBeach

NBEAL1 NSMAF

1.08e-0391042PF02138
Domain-

NBEAL1 NSMAF

1.08e-03910421.10.1540.10
DomainBeach

NBEAL1 NSMAF

1.08e-0391042SM01026
DomainBEACH_dom

NBEAL1 NSMAF

1.08e-0391042IPR000409
DomainMIR

RYR3 ITPR1

1.34e-03101042PF02815
Domain-

PFAS CTPS2

1.34e-031010423.40.50.880
DomainMIR_motif

RYR3 ITPR1

1.34e-03101042IPR016093
DomainMIR

RYR3 ITPR1

1.34e-03101042PS50919
DomainMIR

RYR3 ITPR1

1.34e-03101042SM00472
DomainClass_I_gatase-like

PFAS CTPS2

1.95e-03121042IPR029062
DomainBeta/gamma_crystallin

CRYBG2 CRYBG3

3.08e-03151042IPR001064
DomainCRYSTALLIN_BETA_GAMMA

CRYBG2 CRYBG3

3.08e-03151042PS50915
DomainCrystall

CRYBG2 CRYBG3

3.08e-03151042PF00030
DomainXTALbg

CRYBG2 CRYBG3

3.08e-03151042SM00247
DomainG_crystallin-rel

CRYBG2 CRYBG3

4.43e-03181042IPR011024
PathwayREACTOME_TRANSLESION_SYNTHESIS_BY_Y_FAMILY_DNA_POLYMERASES_BYPASSES_LESIONS_ON_DNA_TEMPLATE

POLD1 USP43 POLI VCP

9.02e-0539864M26897
PathwayREACTOME_TRANSLESION_SYNTHESIS_BY_Y_FAMILY_DNA_POLYMERASES_BYPASSES_LESIONS_ON_DNA_TEMPLATE

POLD1 USP43 POLI VCP

9.02e-0539864MM14475
PathwayKEGG_PYRUVATE_METABOLISM

PKLR PKM DLD ALDH7A1

9.98e-0540864M7934
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

NES REXO4 CASP14 MYO5A ACLY IARS1 POLD1 SENP3 PFAS YBX3 IDH3B PTBP1 GTF3C4 FAM83H DNAJA3 ACSL3 UBN1 ABCE1 RTCA PKM RACGAP1 TIMM44 YME1L1 ALDH7A1 VCP

4.41e-1313531082529467282
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

REXO4 KIF27 TCOF1 ACLY IARS1 POLD1 CHAF1A PFAS YBX3 IDH3B PTBP1 DNAJA3 ACSL3 ABCE1 SURF4 PKM RACGAP1 DLD TIMM44

7.90e-0814251081930948266
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

TCOF1 ACLY IARS1 POLD1 CHAF1A SENP3 DVL3 PTBP1 FAM83H METAP1 DNAJA3 MRPL16 ABCE1 SURF4 PKLR PKM DLD TIMM44

1.27e-0713181081830463901
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

MYO5A TCOF1 USE1 POLD1 MPDZ PFAS ITPR1 DNAJA3 ACSL3 CASKIN2 SURF4 DLD AKT2 TYW1 CRYBG3 TIMM44 YME1L1 FAM177A1 VCP

1.53e-0714871081933957083
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

ACLY IARS1 POLD1 PFAS YBX3 IDH3B PTBP1 GTF3C4 DNAJA3 ACSL3 CTPS2 ABCE1 PKM DLD TIMM44 YME1L1 VCP

3.41e-0712571081737317656
Pubmed

Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved.

IARS1 DNAJA3 ACSL3 ABCE1 SURF4 PKM DLD ALDH7A1

4.16e-07217108830619736
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

MYO5A IARS1 DVL3 PTBP1 ITPR1 DNAJA3 ACSL3 ABCE1 SV2A PKM DLD AKT2 CRYBG3 TIMM44 FAM177A1 VCP

4.76e-0711391081636417873
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

NES CASP14 MYO5A TCOF1 ACLY IARS1 IDH3B PTBP1 FAM83H KIAA1671 ACSL3 SURF4 PKM RACGAP1 VCP

6.67e-0710241081524711643
Pubmed

Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.

TCOF1 ACLY PFAS ACSL3 PKM DLD TIMM44 YME1L1 ALDH7A1 VCP

8.36e-074221081027342126
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

LRRC8E USP13 CASP14 TCOF1 USE1 IARS1 GOLM2 MCAM PTBP1 GTF3C4 ACSL3 SV2A SURF4 PKM LRP1 VCP

9.75e-0712031081629180619
Pubmed

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.

UBA5 NES CASP14 TCOF1 IARS1 DVL3 PFAS METAP1 ACSL3 ABCE1 RTCA CST3 PKM LRP1 DLD ALDH7A1 VCP

1.08e-0613671081732687490
Pubmed

Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.

ACLY IDH3B PKLR PKM DLD ALDH7A1

1.58e-06114108628245920
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

CDK8 TCOF1 POLD1 CHAF1A IDH3B EZH1 FAM83H KIAA1671 DNAJA3 SV2A LRP1 ZFHX3 CRYBG3 YME1L1 VCP

1.93e-0611161081531753913
Pubmed

ATG5 is required for B cell polarization and presentation of particulate antigens.

CWF19L2 POLD1 PTBP1 ITPR1 METAP1 DNAJA3 MRPL16 ABCE1 RTCA PKM YME1L1 VCP

1.96e-067011081230196744
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

UBA5 NES TCOF1 ACLY IARS1 PTBP1 DHRS4 PKM TIMM44

1.96e-06360108933111431
Pubmed

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

ATPSCKMT TRIAP1 DHRS4L2 IDH3B ARMCX2 DNAJA3 AGXT2 DHRS4 CTPS2 MRPL16 RACGAP1 DLD TIMM44 YME1L1 ALDH7A1

2.40e-0611361081534800366
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

USP13 CASP14 TCOF1 IARS1 USP43 MPDZ PFAS CTPS2 ABCE1 RTCA PKLR LRP1 MTCL1 VCP

2.91e-0610051081419615732
Pubmed

The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes.

TRIAP1 DHRS4L2 IDH3B DNAJA3 AGXT2 DHRS4 MRPL16 DLD TIMM44

3.18e-06382108929222160
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

RPGRIP1L USE1 TRIAP1 DYNC2I1 YBX3 IDH3B ARMCX2 ITPR1 KIAA1671 DNAJA3 ACSL3 MRPL16 ABCE1 CRYBG3 TIMM44 YME1L1 VCP

3.64e-0614961081732877691
Pubmed

A protein interaction landscape of breast cancer.

CASP14 MYO5A TCOF1 YBX3 EZH1 GTF3C4 KIAA1671 DNAJA3 LRP1 AKT2 YME1L1

4.73e-066341081134591612
Pubmed

Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization.

MYO5A ACLY DPYSL5 IDH3B ITPR1 SV2A PKM DLD VCP

4.91e-06403108930562941
Pubmed

mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.

CASP14 MYO5A ACLY IARS1 ACSL3 PKM DLD VCP

6.21e-06312108837120454
Pubmed

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.

REXO4 POLD1 CHAF1A SENP3 YBX3 IDH3B PTBP1 MRPL16 RACGAP1

6.46e-06417108936537216
Pubmed

DNA cloning using in vitro site-specific recombination.

LRRC8E UBA5 SEMA4F USP13 REXO4 USE1 SENP3 SV2A SURF4 POLI RACGAP1 ULK1

6.95e-067941081211076863
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

CDK8 TCOF1 ACLY IARS1 POLD1 DVL3 PFAS IDH3B PTBP1 FAM83H ABCE1 PKM RACGAP1 DLD VCP

7.39e-0612471081527684187
Pubmed

Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia.

PKLR PKM

9.55e-062108211960989
Pubmed

Inhibition of Cyclin-Dependent Kinase 8/Cyclin-Dependent Kinase 19 Suppresses Its Pro-Oncogenic Effects in Prostate Cancer.

CDK8 CDK19

9.55e-062108235181333
Pubmed

Regulatory functions of the Mediator kinases CDK8 and CDK19.

CDK8 CDK19

9.55e-062108230585107
Pubmed

Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis.

PKLR PKM

9.55e-062108215996096
Pubmed

Nestin and Notch3 collaboratively regulate angiogenesis, collagen production, and endothelial-mesenchymal transition in lung endothelial cells.

NES NOTCH3

9.55e-062108237735673
Pubmed

HIV Transcription Is Independent of Mediator Kinases.

CDK8 CDK19

9.55e-062108231044597
Pubmed

Alternative transcription initiation and splicing variants of the DHRS4 gene cluster.

DHRS4L2 DHRS4

9.55e-062108218754758
Pubmed

The Complex Effects of PKM2 and PKM2:IP3R Disruption on Intracellular Ca2+ Handling and Cellular Functions.

ITPR1 PKM

9.55e-062108237947604
Pubmed

Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection.

CDK8 CDK19

9.55e-062108232560467
Pubmed

Low-density lipoprotein receptor-related protein 1 is a novel modulator of radial glia stem cell proliferation, survival, and differentiation.

NES LRP1

9.55e-062108227258849
Pubmed

Abnormal PTBP1 Expression Sustains the Disease Progression of Multiple Myeloma.

PTBP1 PKM

9.55e-062108232655719
Pubmed

[Mechanisms of transcriptional regulation upon protein phosphorylation by mediator complexes].

CDK8 CDK19

9.55e-062108220408451
Pubmed

CDNA cloning of a short isoform of human liver NADP (H) -dependent retinol dehydrogenase/reductase and analysis of its characteristics.

DHRS4L2 DHRS4

9.55e-062108215473316
Pubmed

Mediator kinase inhibition further activates super-enhancer-associated genes in AML.

CDK8 CDK19

9.55e-062108226416749
Pubmed

CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.

CDK8 CDK19

9.55e-062108228855340
Pubmed

The molecular motor Myosin Va interacts with the cilia-centrosomal protein RPGRIP1L.

RPGRIP1L MYO5A

9.55e-062108228266547
Pubmed

Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells.

PTBP1 PKM

9.55e-062108226234680
Pubmed

Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer.

CDK8 CDK19

9.55e-062108227678455
Pubmed

CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF.

CDK8 CDK19

9.55e-062108236006697
Pubmed

Myosin Va and Endoplasmic Reticulum Calcium Channel Complex Regulates Membrane Export during Axon Guidance.

MYO5A RYR3

9.55e-062108227134178
Pubmed

Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma.

DHRS4L2 DHRS4

9.55e-062108217230527
Pubmed

CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins.

CDK8 CDK19

9.55e-062108237378433
Pubmed

Nestin and cluster of differentiation 146 expression in breast cancer: Predicting early recurrence by targeting metastasis?

NES MCAM

9.55e-062108228347241
Pubmed

Identification of target genes for the CDK subunits of the Mediator complex.

CDK8 CDK19

9.55e-062108222117896
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

TCOF1 ACLY POLD1 IFT172 DPYSL5 MPDZ PFAS ACSL3 ABCE1 LRP1 DLD YME1L1 VCP

1.07e-059741081328675297
Pubmed

USP11 mediates repair of DNA-protein cross-links by deubiquitinating SPRTN metalloprotease.

IARS1 SENP3 PTBP1 DNAJA3 ACSL3 CTPS2 ABCE1 PKM YME1L1 VCP

1.10e-055651081033567341
Pubmed

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.

POLD1 IDH3B RACGAP1 AKT2 MTCL1 YME1L1 VCP

1.11e-05242108734011540
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

NES MYO5A TCOF1 ACLY IARS1 POLD1 MPDZ PFAS YBX3 PTBP1 DNAJA3 PKM ALDH7A1 VCP

1.33e-0511491081435446349
Pubmed

Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.

TCOF1 TRIAP1 ACLY MCAM IDH3B ARMCX2 PKM LRP1 DLD TIMM44 ALDH7A1 VCP

1.52e-058591081231536960
Pubmed

The LIFEdb database in 2006.

LRRC8E UBA5 SEMA4F USP13 REXO4 USE1 SENP3 SV2A SURF4 POLI RACGAP1

1.55e-057201081116381901
Pubmed

From ORFeome to biology: a functional genomics pipeline.

LRRC8E UBA5 SEMA4F USP13 REXO4 USE1 SENP3 SV2A SURF4 POLI RACGAP1

1.59e-057221081115489336
Pubmed

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

TCOF1 ACLY IARS1 MPDZ YBX3 PTBP1 GTF3C4 DNAJA3 CTPS2 MRPL16 PKM DLD YME1L1 ALDH7A1 VCP

1.65e-0513351081529229926
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

SEMA4F NES RPGRIP1L CHAF1A DYNC2I1 MPDZ GTF3C4 RACGAP1 AKT2 TYW1 TIMM44

1.83e-057331081134672954
Pubmed

A mitochondrial protein compendium elucidates complex I disease biology.

TRIAP1 ACLY DHRS4L2 IDH3B DNAJA3 AGXT2 DHRS4 CTPS2 MRPL16 DLD TIMM44 YME1L1 ALDH7A1

2.27e-0510471081318614015
Pubmed

MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1.

ACLY PTBP1 ACSL3 ABCE1 PKM VCP

2.33e-05182108630711629
Pubmed

Repression of rRNA transcription by PARIS contributes to Parkinson's disease.

ACLY IARS1 POLD1 SENP3 YBX3 PKM TIMM44

2.36e-05272108725315684
Pubmed

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

NES CASP14 MYO5A ACLY MPDZ PLEKHG2 KIAA1671 MRPL16 SURF4 RACGAP1 DLD YME1L1

2.85e-059161081232203420
Pubmed

Amplification of USP13 drives ovarian cancer metabolism.

USP13 ACLY

2.86e-053108227892457
Pubmed

CpG island evolution in the mammalian DHRS4 gene cluster and its role in the regulation of gene transcription.

DHRS4L2 DHRS4

2.86e-053108227323117
Pubmed

Mediator complex cooperatively regulates transcription of retinoic acid target genes with Polycomb Repressive Complex 2 during neuronal differentiation.

CDK8 CDK19

2.86e-053108226002960
Pubmed

Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase.

DHRS4L2 DHRS4

2.86e-053108210333503
Pubmed

Bioinformatic analysis of the human DHRS4 gene cluster and a proposed mechanism for its transcriptional regulation.

DHRS4L2 DHRS4

2.86e-053108220525226
Pubmed

A variation in mouse kidney pyruvate kinase activity determined by a mutant gene on chromosome 9.

MYO5A PKM

2.86e-05310827262549
Pubmed

Reduction of all-trans-retinal in the mouse liver peroxisome fraction by the short-chain dehydrogenase/reductase RRD: induction by the PPAR alpha ligand clofibrate.

DHRS4L2 DHRS4

2.86e-053108212680773
Pubmed

Myosin 5a is an insulin-stimulated Akt2 (protein kinase Bbeta) substrate modulating GLUT4 vesicle translocation.

MYO5A AKT2

2.86e-053108217515613
Pubmed

TCF3 mutually exclusive alternative splicing is controlled by long-range cooperative actions between hnRNPH1 and PTBP1.

TCF3 PTBP1

2.86e-053108231391218
Pubmed

Pyrimidine tract-binding protein 1 mediates pyruvate kinase M2-dependent phosphorylation of signal transducer and activator of transcription 3 and oncogenesis in anaplastic large cell lymphoma.

PTBP1 PKM

2.86e-053108228414323
Pubmed

Mediator cyclin-dependent kinases upregulate transcription of inflammatory genes in cooperation with NF-κB and C/EBPβ on stimulation of Toll-like receptor 9.

CDK8 CDK19

2.86e-053108228151579
Pubmed

Low density lipoprotein receptor-related protein-1 (LRP1) regulates thrombospondin-2 (TSP2) enhancement of Notch3 signaling.

LRP1 NOTCH3

2.86e-053108220472562
Pubmed

FGF2 stimulates SDF-1 expression through the Erm transcription factor in Sertoli cells.

ETV5 FGF2

2.86e-053108219301256
Pubmed

The relationship among integrin alpha 7, CD133 and Nestin as well as their correlation with clinicopathological features and prognosis in astrocytoma patients.

NES ITGA7

2.86e-053108235430343
Pubmed

Proliferating cell nuclear antigen (PCNA) may function as a double homotrimer complex in the mammalian cell.

POLD1 CHAF1A

2.86e-053108215805117
Pubmed

The IKKβ-USP30-ACLY Axis Controls Lipogenesis and Tumorigenesis.

ACLY IKBKB

2.86e-053108232221968
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

UBA5 ACLY IARS1 POLD1 IFT172 IDH3B FAM83H PKM TIMM44 VCP

3.11e-056381081033239621
Pubmed

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.

UBA5 TCF3 REXO4 MYO5A USE1 IARS1 POLD1 GOLM2 PFAS CASKIN2 SURF4 POLI

3.14e-059251081228986522
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

TCOF1 ACLY IARS1 POLD1 PFAS YBX3 IDH3B PTBP1 DNAJA3 CTPS2 SLC16A3 PKM MTCL1 TIMM44 VCP

3.23e-0514151081528515276
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

USP13 SENP3 MPDZ PFAS ITPR1 CASKIN2 ABCE1 RACGAP1 ULK1 CRYBG3

3.64e-056501081038777146
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

NES REXO4 MYO5A TCOF1 ACLY PFAS ACSL3 ABCE1 DLD VCP

3.78e-056531081022586326
Pubmed

AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis.

ACLY IARS1 PFAS PTBP1 PKM VCP

3.94e-05200108635546148
Pubmed

PTB deficiency causes the loss of adherens junctions in the dorsal telencephalon and leads to lethal hydrocephalus.

NES PTBP1 PKM

4.30e-0522108322705452
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

UBA5 ACLY IARS1 POLD1 PFAS YBX3 PTBP1 GTF3C4 CTPS2 ABCE1 PKM DLD IKBKB ALDH7A1 VCP

4.44e-0514551081522863883
Pubmed

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.

CASP14 KIF27 PTBP1 PKLR PKM IKBKB ALDH7A1

4.77e-05304108732235678
Pubmed

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.

CASP14 TCOF1 YBX3 PTBP1 GTF3C4 DNAJA3 RTCA PKM LRP1 RACGAP1 MTCL1 TIMM44

5.01e-059711081233306668
Pubmed

FGF11 induced by hypoxia interacts with HIF-1α and enhances its stability.

SENP3 YBX3 PTBP1 ACSL3 VCP

5.14e-05128108528027390
Pubmed

RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.

REXO4 ACLY IARS1 POLD1 YBX3 PTBP1 RTCA PKM

5.65e-05425108821081503
Pubmed

Bioinformatic identification and characterization of new members of short-chain dehydrogenase/reductase superfamily.

DHRS4L2 DHRS4

5.71e-054108216406282
Pubmed

Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.

CDK8 CDK19

5.71e-054108229440396
Pubmed

Ryanodine receptor calcium release channels: lessons from structure-function studies.

RYR3 ITPR1

5.71e-054108223413940
Pubmed

ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97.

ULK1 VCP

5.71e-054108230979586
Pubmed

Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.

RYR3 ITPR1

5.71e-05410829607712
Pubmed

A LewisX glycoprotein screen identifies the low density lipoprotein receptor-related protein 1 (LRP1) as a modulator of oligodendrogenesis in mice.

NES LRP1

5.71e-054108223615909
Pubmed

Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes.

DHRS4L2 DHRS4

5.71e-054108223036705
Pubmed

Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development.

CDK8 CDK19

5.71e-054108232439758
Pubmed

RNF170 protein, an endoplasmic reticulum membrane ubiquitin ligase, mediates inositol 1,4,5-trisphosphate receptor ubiquitination and degradation.

ITPR1 VCP

5.71e-054108221610068
Pubmed

An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5-trisphosphate receptors.

ITPR1 VCP

5.71e-054108219240031
InteractionATG16L1 interactions

CWF19L2 USP13 RPGRIP1L MYO5A POLD1 PFAS PTBP1 ITPR1 METAP1 DNAJA3 MRPL16 ABCE1 SURF4 RTCA PKM MTCL1 ULK1 CRYBG3 YME1L1 VCP

2.34e-06116110620int:ATG16L1
InteractionEGLN3 interactions

TCF3 POLD1 IFT172 DVL3 DYNC2I1 PFAS IDH3B GTF3C4 FAM83H KIAA1671 DNAJA3 ACSL3 ABCE1 PKM RACGAP1 MTCL1 IKBKB TIMM44 YME1L1 NOTCH3 VCP

3.29e-06129610621int:EGLN3
InteractionGSK3B interactions

CASP14 ACLY GOLM2 MPDZ PFAS YBX3 PTBP1 KIAA1671 ACSL3 ABCE1 PKM AKT2 MTCL1 CRYBG3 NOTCH3 VCP

1.19e-0586810616int:GSK3B
InteractionHIF1A interactions

CDK8 NES NBEAL1 SENP3 IDH3B PTBP1 DNAJA3 PKM RACGAP1 IKBKB VCP

2.09e-0544110611int:HIF1A
InteractionNR2C2 interactions

TCOF1 ACLY IARS1 POLD1 CHAF1A SENP3 DVL3 PTBP1 FAM83H METAP1 DNAJA3 UBN1 MRPL16 ABCE1 SURF4 PKLR PKM DLD IKBKB TIMM44

3.78e-05140310620int:NR2C2
GeneFamilyBeta-gamma crystallin domain containing

CRYBG2 CRYBG3

5.08e-0537521360
GeneFamilyWD repeat domain containing|BEACH domain containing

NBEAL1 NSMAF

6.00e-0497521230
CoexpressionBLANCO_MELO_BRONCHIAL_EPITHELIAL_CELLS_INFLUENZA_A_INFECTION_UP

NBEAL1 ITGA7 IFI35 GTF3C4 ITPR1 NLRC5 CRYBG3

1.54e-061371077M34024
CoexpressionGSE15330_GRANULOCYTE_MONOCYTE_PROGENITOR_VS_PRO_BCELL_UP

MYO5A TCOF1 ACLY SENP3 GTF3C4 RTCA RACGAP1 TYW1

1.64e-061991078M7041
CoexpressionBLUM_RESPONSE_TO_SALIRASIB_UP

MYO5A IARS1 DNAJA3 RTCA POLI LRP1 TIMM44 NSMAF

7.64e-062451078M7300
CoexpressionDEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN

TCF3 PFAS ITGA7 ITPR1 SLC38A10 SV2A ULK1 NOTCH3

1.81e-052761078M3063
CoexpressionGSE3982_MAC_VS_BASOPHIL_UP

MYO5A TRIAP1 POLD1 ETV5 ACSL3 RTCA NSMAF

1.86e-052001077M5496
ToppCellCOVID-19-Heart-Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

NBEAL1 MCAM PLEKHG2 ITGA7 SETBP1 ZFHX3 NOTCH3

3.36e-07184108721790cdfa3b4036ad413fd44b94e31563116f25f
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NES DPYSL5 MCAM ITGA7 ITPR1 ZFHX3 NOTCH3

3.61e-0718610874780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCelldroplet-Marrow-BM-1m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDK8 TCF3 POLD1 YBX3 IFI35 DLD VCP

4.97e-071951087637b06ef3967b03f7165d102d316e8b7161a817d
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NES MCAM ETV5 LRP1 HAS2 NOTCH3

3.71e-0617010865570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCAM PLEKHG2 ITGA7 KIAA1671 ZFHX3 NOTCH3

4.10e-0617310862415b6ff49f334da570577d4e93484d024a3dbd5
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCAM PLEKHG2 ITGA7 KIAA1671 ZFHX3 NOTCH3

4.10e-0617310862acd0693a2dfe04e3c1b2125ea63efe92d13150b
ToppCellPericytes-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

NES MCAM ITGA7 MEIS3P1 HAS2 NOTCH3

5.31e-06181108635c470988a93381eefa300831aabb813fa1b90bd
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NES DPYSL5 MCAM ITGA7 ZFHX3 NOTCH3

6.81e-061891086975e7aa3b862a8b07c2ab8426a14f5cc54998aca
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NES MCAM PLEKHG2 ARMCX2 CST3 NOTCH3

7.01e-061901086951e067d14412db67dc3babcdf61e41717d7b429
ToppCellMatrixFB-Fibroblast-D_(Pericyte)|MatrixFB / shred on cell class and cell subclass (v4)

MCAM ITGA7 ARMCX2 KIAA1671 CST3 NOTCH3

7.45e-061921086630444302511f511ec6976bc045a3b4b9d8d4547
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NES TCF3 ITGA7 RYR3 ACSL3 CST3

7.90e-06194108668d15917ae222cba0ad9e716d29eebb6c5f00f69
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCAM PLEKHG2 ITGA7 KIAA1671 ZFHX3 NOTCH3

8.38e-061961086184104cbea0461dd2757668ab9755948ac7b585a
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCAM PLEKHG2 ITGA7 KIAA1671 ZFHX3 NOTCH3

8.38e-061961086bebb20dc210576101c317011e3afb59798f5d255
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCAM PLEKHG2 ITGA7 KIAA1671 ZFHX3 NOTCH3

8.38e-0619610868114e98923096c54b6834f21550c3061bab6773d
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Fezf2-Excitatory_Neuron.Slc17a7-Slc17a8.Fezf2-Slc17a8_(Layer_5,_Retrosplenial_cortex_(RSG)_and_Subiculum,_Tshz2+)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

LRRC8E CASP14 CDHR1 FAM177A1

2.85e-05721084e3f4d1df43cc41b0424f27485a00ddca9e905f95
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NES ITGA7 SV2A ZFHX3 NOTCH3

3.47e-0515210850cb5f4dfae04e3f4eba502bbf229007d5fa3884d
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NES ITGA7 SV2A ZFHX3 NOTCH3

3.47e-051521085ba89ffb5a8bb33c188f854f54b39123b6d73496a
ToppCellfacs-Brain_Myeloid-Hippocampus-24m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CRYBG2 ITGA7 CST3 LRP1 ZFHX3

5.43e-0516710857f3224af9b30082b927a822b91f96e0c88151b4e
ToppCellfacs-Brain_Myeloid-Hippocampus-24m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CRYBG2 ITGA7 CST3 LRP1 ZFHX3

5.43e-051671085a21a2b301d0a3d7a41e605f7a3c37548962a331d
ToppCellfacs-Brain_Myeloid-Hippocampus-24m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CRYBG2 ITGA7 CST3 LRP1 ZFHX3

5.43e-0516710850e746483773bde6582874a33591ab2a578d724eb
ToppCell356C-Fibroblasts-Fibroblast-H-|356C / Donor, Lineage, Cell class and subclass (all cells)

ARMCX2 SV2A FGF2 HAS2 NOTCH3

5.59e-051681085b5d74500bdac0d680ce7eb7afa0b867b8d85e6a4
ToppCell356C-Fibroblasts-Fibroblast-H|356C / Donor, Lineage, Cell class and subclass (all cells)

ARMCX2 SV2A FGF2 HAS2 NOTCH3

5.59e-051681085838ce47d4958ba12047882f97925eddd02f081c7
ToppCellfacs-Brain_Myeloid-Hippocampus-24m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CRYBG2 ITGA7 CST3 LRP1 ZFHX3

5.91e-051701085b4f2c05db2c2591561fd42febc72eed3b5e8f9fb
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MCAM ITGA7 CST3 ZFHX3 NOTCH3

6.60e-051741085778e0317c0c63fa4efd74114feb760975b819d92
ToppCellnormal_Lymph_Node-Myeloid_cells-pDCs|Myeloid_cells / Location, Cell class and cell subclass

CDK8 PFAS PLEKHG2 RGS7 SETBP1

6.60e-0517410852274648b80dd74f3c948a779bba3391095964c34
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MCAM ARMCX2 RACGAP1 ZFHX3 NOTCH3

6.78e-051751085fa16c6ba08dc0cc22e8cf049db0577811d080df6
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NBEAL1 ITGA7 SETBP1 ZFHX3 NOTCH3

6.78e-051751085316f2ea930437bf1243b1c0f45e6bd864112c6f2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NBEAL1 ITGA7 SETBP1 ZFHX3 NOTCH3

6.78e-051751085a9f08e1e4c2997dcdd3e5d92daac480da19100b8
ToppCellnormal_Lymph_Node-Myeloid_cells-pDCs|normal_Lymph_Node / Location, Cell class and cell subclass

CDK8 PFAS PLEKHG2 RGS7 SETBP1

6.96e-051761085476794ef75ce5ab732d78cfeb4944e2f841e3e92
ToppCellCOVID-19-kidney-vSMC/Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

NBEAL1 MCAM SETBP1 ZFHX3 NOTCH3

7.54e-051791085111b1084f73306bdeffaaf240e7dbb4f5bf33de1
ToppCell3'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IFT172 ETV5 CPLX3 ZFHX3 ULK1

7.54e-051791085906555ce2ca264a0215b120c7ff7c9b411de6a34
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Aerocyte_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NES DPYSL5 IFI35 PRX CASKIN2

7.95e-051811085cd81bc307e2bc42c1e9b24d5645ab65fa18c6133
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NES REXO4 ACLY MCAM CASKIN2

7.95e-051811085709e9c7a60d5f98635b99895ce30bb87a9f7376d
ToppCellPericytes-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

MCAM ITGA7 SV2A FGF2 NOTCH3

8.37e-051831085d04deef7cd4e1738227a6593b84874ce0168c773
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PLEKHG2 ITGA7 TMEM132C ZFHX3 NOTCH3

8.81e-05185108551dfe6ac7df8b330343b37e3bee71e5c65267189
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PLEKHG2 ITGA7 TMEM132C ZFHX3 NOTCH3

8.81e-051851085a8c02cec3c414f3a0da9f2d6d28ce563b0030705
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NES MCAM ITGA7 ZFHX3 NOTCH3

9.04e-051861085a95744b8649096bd7cfc3591a02841fa411085b3
ToppCellP07-Mesenchymal-myocytic_cell-vascular_associated_smooth_muscle_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ITGA7 RGS7 CST3 ZFHX3 NOTCH3

9.50e-0518810856ec22b79b19d57ea187f312907819dc2d01f3efe
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCAM ITGA7 ZFHX3 MTCL1 NOTCH3

9.74e-051891085de51fbd6fdb24fc4549393cf41a020005444b2aa
ToppCellLA-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

NBEAL1 MCAM RYR3 ITPR1 NOTCH3

9.74e-0518910856b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCelldroplet-Kidney-nan-21m-Epithelial-kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NES MCAM ITGA7 ZFHX3 NOTCH3

9.99e-0519010851803b1e7c36285f9eaabc3c6e9a9752c5908db3d
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NES MCAM CST3 ZFHX3 NOTCH3

9.99e-05190108510b02c62e72bfea9767e3e751011436925da823e
ToppCellE15.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NES MCAM PLEKHG2 ARMCX2 NOTCH3

9.99e-05190108584fbd5664ec886120963d4f50dfa1fd1851d36c1
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MCAM ITGA7 TMEM132C ZFHX3 NOTCH3

1.02e-04191108508042952431ca1a6fd7dfc13f36eb28643979598
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MCAM ITGA7 ITPR1 ZFHX3 NOTCH3

1.02e-0419110857853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NBEAL1 ITGA7 SETBP1 ZFHX3 NOTCH3

1.02e-04191108504c4d454b57e29a8d1dcdeb4678ce71bdc29b77b
ToppCelldroplet-Pancreas-Endocrine|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACLY CHGA SLC38A10 PKM VCP

1.05e-0419210850dfd1e9896c34aee0f842f8de5d0e3af62a15f68
ToppCell(1)_Control_(PBS)-(3)_LEPR+_perivascular_cells|(1)_Control_(PBS) / Stress and Cell class

MPDZ CST3 LRP1 ALDH7A1 NOTCH3

1.05e-04192108540f380f5f0bed63a7404be050838ebd01ef08987
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

NES MCAM ZFHX3 MTCL1 NOTCH3

1.07e-041931085000b9e6a819b94ea2e6e9173daf97ba9ac2b6cc6
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MCAM ITGA7 CST3 ZFHX3 NOTCH3

1.07e-04193108588916d9a7d831eb52848599917c04238f8f9812b
ToppCellfacs-Lung-18m-Endothelial-capillary_endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NES GOLM2 MCAM PRX CASKIN2

1.07e-041931085ee4b31d9c92f8fd0d3ddb5e723b82300fcb459d1
ToppCellfacs-Lung-18m-Endothelial-capillary_endothelial-capillary_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NES GOLM2 MCAM PRX CASKIN2

1.07e-0419310857401e276b644b254c692160d0e7417ec28d50aa4
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MCAM ITGA7 CST3 ZFHX3 NOTCH3

1.07e-0419310857386fadc13a437f3b0c99b5d116cd3c5f893529c
ToppCelldroplet-Pancreas-Endocrine-21m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACLY CHGA SLC38A10 PKM VCP

1.10e-0419410853a3ecedcdc7691cf21775818b598208fcb980c29
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_neuro-secretory|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CHGA RGS7 RACGAP1 ZNF221 ALDH7A1

1.10e-041941085d024cd75a97f048257e49cee9190fb2e79202ee2
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MCAM ITGA7 CST3 ZFHX3 NOTCH3

1.10e-0419410856a4e7f1bf67bad94cd8c472e7c66798b0c25ba01
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACLY CHGA SLC38A10 PKM VCP

1.10e-0419410850b023de48ed8a550d169bbe954881eb04bf4f981
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

NES MCAM ZFHX3 MTCL1 NOTCH3

1.10e-04194108567f5e2f05a8de2213ab80d5ea16fdee121684633
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TCOF1 YBX3 ITPR1 SETBP1 AKT2

1.13e-041951085481989d2e5bd2582da3d86b0155c4d6615317067
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TCOF1 YBX3 ITPR1 SETBP1 AKT2

1.13e-0419510856108a27523d1b93a7fbe35cb95704a5ad9071e3c
ToppCellPND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NES MCAM ARMCX2 CST3 NOTCH3

1.13e-0419510854a5d2f62aad5817d077177bf8b4ff0e46d3b8d97
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NES CWF19L2 MPDZ RYR3 TIMM44

1.13e-04195108532ec72103faccc9e37c0ecedff1998e7df6a19f6
ToppCellfacs-Brain_Myeloid-Hippocampus|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ETV5 CHGA CST3 LRP1 ZFHX3

1.13e-041951085a1478021a3ed0e779716393124ca2a7770c433b7
ToppCellPND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NES MCAM ARMCX2 CST3 NOTCH3

1.13e-0419510857a32a8535c29b819dacba901d0658280a2631c94
ToppCellFibroblasts-Pericytes|Fibroblasts / lung cells shred on cell class, cell subclass, sample id

NES MCAM ITGA7 ZFHX3 NOTCH3

1.13e-041951085c2ebc0b33bda9b35b9ef26d69e5d2c6acfdb6ff1
ToppCellPND01-Mesenchymal-Mesenchymal_myocytic|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NES MCAM ARMCX2 CST3 NOTCH3

1.16e-041961085acbb493dbb49a33f20cf11106363f7ed51209706
ToppCellPND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NES MCAM ARMCX2 CST3 NOTCH3

1.16e-0419610856708026bafd19c35c5c4e81911344d36a0f508cd
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RPGRIP1L KIF27 USP43 DYNC2I1 MPDZ

1.18e-04197108574a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCellASK452-Endothelial-Endothelium|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

NES MCAM YBX3 PRX CASKIN2

1.21e-041981085e282769f5fa1765bcce79a0ed9d761bf2e14b012
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

HCN3 CHGA RGS7 KIAA1671 ZNF221

1.21e-041981085d6812494874be0c14361ac2ac3e418b335bb8f55
ToppCellnormal_Lung-Fibroblasts-Smooth_muscle_cells|Fibroblasts / Location, Cell class and cell subclass

NES MCAM ITGA7 KIAA1671 NOTCH3

1.24e-041991085d65847ceb68a560798df3f73e6f838e7c3e38a1c
ToppCellNon-neuronal-Non-dividing-Radial_Glia-early|World / Primary Cells by Cluster

NES NBEAL1 MCAM PTBP1 PKM

1.24e-041991085549391e7a4285da1c0e366654530bcf1cd33fbae
ToppCellNon-neuronal-Non-dividing-Radial_Glia-early-40|World / Primary Cells by Cluster

NES NBEAL1 MCAM PTBP1 PKM

1.24e-04199108523625d757173bdd35a51c7919ff4b588168d2553
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GOLM2 RYR3 CST3 LRP1 ALDH7A1

1.24e-041991085a900ef002e1ae583b70be0253d8c44dae6754916
ToppCellBrain_organoid-organoid_Tanaka_cellReport-6m|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.

NES NBEAL1 YBX3 ITGA7 CST3

1.27e-0420010855ba4ed490c64b3bb738e7729669f893fa73aa56f
ToppCellTracheal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CDK8 NES PLEKHG2 CRYBG3 NSMAF

1.27e-042001085410b1a31de21c57d87ca2104f61cf4a7d4dd2f30
ToppCellmild-Myeloid-CD14_Monocytes_1|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

YBX3 CST3 PKM LRP1 ZFHX3

1.27e-0420010853874c1f078cb8789be2e2275a202357c711b1be3
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLC1A7 TMEM132C SETBP1 LRP1 HAS2

1.27e-04200108574e74123ea7bf38d337a3a0248a6a51437c6ab42
ToppCellBrain_organoid-organoid_Tanaka_cellReport-2m-Macroglial-Glia_progenitor_cell|2m / Sample Type, Dataset, Time_group, and Cell type.

NES IARS1 YBX3 SLC16A3 PKM

1.27e-042001085fc9e2094f4d22412e3dd79e79649a6d46d62caec
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c10-MKI67-GZMK|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

POLD1 RDM1 CASKIN2 RACGAP1

4.28e-04145108434fc6da04d4fe0817e37cdcd844fe2a6e53a4796
ToppCell10x5'-bone_marrow-Myeloid_Monocytic-Cycling_mono|bone_marrow / Manually curated celltypes from each tissue

ITGA7 SLC16A3 PKM LRP1

4.62e-041481084de35eeefad0e27a0d127e2e4bedead2bddb75152
ToppCellFetal_29-31_weeks-Mesenchymal-chondrocyte-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

LRRC8E DPYSL5 CHGA HAS2

5.24e-04153108465641cc82883716dba0fefb749a30174a63f4da5
ToppCellLPS-antiTNF-Stromal_mesenchymal-Myocytic|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MCAM ITGA7 ZFHX3 NOTCH3

5.63e-0415610846365b69ede98bc866e996bc52736b00401aacf6f
ToppCellPBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SEMA4F CRYBG2 CHAF1A IGSF22

5.63e-04156108484f01419d8c116714e8c8c857c4d153a755b7867
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ATPSCKMT MPDZ PFAS RYR3

5.63e-041561084895927228c93cd090303984c5be6ebfb59ed6f3a
ToppCellPBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SEMA4F CRYBG2 CHAF1A IGSF22

5.63e-0415610842285be9746d0d0f62a488b9c64fa67a834758dd7
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Fibroblasts|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NES ITGA7 FAM83H ITPR1

5.77e-041571084f086753b51860e23f1275bd75e8802d2a7d7b70a
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

NES TMEM132C ZFHX3 MTCL1

5.77e-041571084b9d04ee417c0d8ea0801d10f1c54e138587009fd
ToppCellfrontal_cortex-Non-neuronal-smooth_muscle_cell|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MCAM PLEKHG2 ZFHX3 NOTCH3

5.91e-04158108408806240228c5b780f5aef92ce2c278ae4d797cc
ToppCellfrontal_cortex-Non-neuronal-smooth_muscle_cell-SMC-SMC_Acta2|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MCAM PLEKHG2 ZFHX3 NOTCH3

5.91e-041581084496b6988f7b3439968351840ae22f56ffa1643f1
ToppCellfrontal_cortex-Non-neuronal-smooth_muscle_cell-SMC|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MCAM PLEKHG2 ZFHX3 NOTCH3

5.91e-0415810845b3d30f92b619f14a7b48502170000fa5783358a
ToppCellChildren_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

MCAM ITGA7 SV2A NOTCH3

5.91e-04158108484c0a215dabf697ada036c2b9592d0c61b5077de
ToppCellControl-Endothelial_cells-Inflamed_endothelial_cells|Control / group, cell type (main and fine annotations)

NES MCAM PRX CASKIN2

6.19e-041601084958256e3d3836160763b82bb48f794087918d935
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

MPDZ GTF3C4 ABCE1 ZNF221

6.19e-0416010848bb873704895c3b35bba8af78fedbabf7df42e71
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLEKHG2 ITGA7 ZFHX3 NOTCH3

6.49e-041621084c7114e24cb5525abb9780ca3d35dbcc4eabd4b64
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLEKHG2 ITGA7 ZFHX3 NOTCH3

6.49e-041621084f1851a173d3bcca2981d934161ec85d1cc0af5a2
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLEKHG2 ITGA7 ZFHX3 NOTCH3

6.49e-0416210845d902bb31e691aea9749617cc88303c2448f24b8
ToppCellLPS-IL1RA-Unknown-Endothelial-Monocytes-Macrophages|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

REXO4 POLD1 ABCE1 POLI

6.64e-0416310846b11a3ada8725670d0489f404c8c2175ad3904e9
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-neuron_precursor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

USP43 CHGA SLC1A7 SRRM3

6.64e-04163108499cf60dc87f7ce288553091bffcd85109a02bd8f
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

USP43 CHGA SLC1A7 SRRM3

6.64e-041631084510c0af66e82c5a8cf8edd0547dae4018a87dbbf
DrugPyruvic acid

AGXT2 SLC16A3 PKLR PKM

4.45e-07141074DB00119
DrugAC1N02M5

IDH3B PKLR PKM

8.30e-0691073CID003956233
Drug1,3-butanedione

IDH3B PKLR PKM

2.15e-05121073CID000022747
Drug2-Phosphoglycolic Acid

PKLR PKM

2.19e-0521072DB02726
DrugN-methyltaurine

PKLR PKM

2.19e-0521072CID000007882
DrugNPCMD

PKLR PKM

2.19e-0521072CID000126341
DrugBW A440C

PKLR PKM

2.19e-0521072CID003086296
Drug3-(fluoromethyl)phosphoenolpyruvate

PKLR PKM

2.19e-0521072CID006443899
DrugSENP

PKLR PKM

2.19e-0521072CID003082911
Drug8-BDB-TATP

PKLR PKM

2.19e-0521072CID003082732
DrugAC1Q6SAF

PKLR PKM

2.19e-0521072CID000194977
DrugAdenosine 5'-monophosphate 1-oxide

PKLR PKM

2.19e-0521072CID000492161
Drugadenine

TCF3 POLD1 ETV5 PFAS IDH3B RYR3 PKLR POLI PKM DLD ALDH7A1

2.86e-0551010711CID000000190
Drug0317956-0000 [391210-11-0]; Down 200; 10uM; MCF7; HT_HG-U133A

TCF3 DVL3 ETV5 EZH1 ITPR1 MTCL1 IKBKB

3.26e-0519010773966_DN
DrugNorethindrone [68-22-4]; Up 200; 13.4uM; MCF7; HT_HG-U133A

TCF3 RPGRIP1L ETV5 EZH1 SLC1A7 ITPR1 IKBKB

3.84e-0519510775474_UP
DrugDimethadione [695-53-4]; Up 200; 31uM; HL60; HT_HG-U133A

NES CRYBG2 MPDZ SETBP1 LRP1 FGF2 ZFHX3

3.97e-0519610773029_UP
DrugDeferoxamine mesylate [138-14-7]; Down 200; 6uM; MCF7; HT_HG-U133A

TCF3 RPGRIP1L MPDZ PTBP1 SLC16A3 ZFHX3 IKBKB

3.97e-0519610773842_DN
DrugArtemisinin [63968-64-9]; Down 200; 14.2uM; MCF7; HT_HG-U133A

TCOF1 USE1 SENP3 DYNC2I1 EZH1 MTCL1 NOTCH3

4.23e-0519810777007_DN
Drugoxaloacetate

ACLY IDH3B AGXT2 RTCA PKLR PKM DLD

4.23e-051981077CID000000970
Drugglutamate

NES PFAS IDH3B SLC1A7 RYR3 ITPR1 AGXT2 CTPS2 SV2A PKLR PKM FGF2 DLD YME1L1 ALDH7A1

4.36e-0596210715CID000000611
DrugCloethocarb

DPYSL5 PRX CST3 IKBKB

5.92e-05451074CID000040032
Drugdiethoxyfluorescein

PKLR PKM

6.54e-0531072CID000161373
DrugNSC 18508

PKLR PKM

6.54e-0531072CID000189182
Drug1-thio-alpha-tocopherol

PKLR PKM

6.54e-0531072CID000131683
Drug2 PEB

PKLR PKM

6.54e-0531072CID000447809
Drugpotassium

NES MYO5A POLD1 HCN3 RGS7 SLC1A7 RYR3 ITPR1 METAP1 SV2A PKLR PKM AKT2 YME1L1 ALDH7A1

7.39e-05100810715CID000000813
Diseasedevelopmental and epileptic encephalopathy 87 (implicated_via_orthology)

CDK8 CDK19

1.25e-0521052DOID:0112221 (implicated_via_orthology)
Diseaseprostate adenocarcinoma (is_implicated_in)

FGF2 AKT2 IKBKB

4.78e-05201053DOID:2526 (is_implicated_in)
Diseasedisease of metabolism (implicated_via_orthology)

PKLR PKM DLD

5.56e-05211053DOID:0014667 (implicated_via_orthology)
Diseaseprostate cancer (is_implicated_in)

CHGA ACSL3 ZFHX3 AKT2 IKBKB

6.33e-051171055DOID:10283 (is_implicated_in)
DiseaseCerebrovascular accident

RGS7 CST3 ZFHX3 NOTCH3

7.21e-05621054C0038454
Diseasedermatitis (is_implicated_in)

FGF2 IKBKB

1.86e-0461052DOID:2723 (is_implicated_in)
Diseaseepilepsy (implicated_via_orthology)

ITGA7 SLC1A7 SV2A LRP1 ALDH7A1

2.99e-041631055DOID:1826 (implicated_via_orthology)
DiseaseNephronophthisis

RPGRIP1L IFT172

4.44e-0491052cv:C0687120
DiseaseTonic-Clonic Epilepsy

NES FGF2

5.54e-04101052C0014549
DiseaseCryptogenic Tonic-Clonic Epilepsy

NES FGF2

5.54e-04101052C0751117
DiseaseEpilepsy, Tonic-Clonic, Symptomatic

NES FGF2

5.54e-04101052C0751119
DiseaseEpilepsy, Tonic-Clonic, Familial

NES FGF2

5.54e-04101052C0751118
DiseaseJeune thoracic dystrophy

IFT172 DYNC2I1

6.76e-04111052C0265275
Diseaseearly infantile epileptic encephalopathy (implicated_via_orthology)

UBA5 IDH3B

6.76e-04111052DOID:0050709 (implicated_via_orthology)
DiseaseShort Rib-Polydactyly Syndrome

IFT172 DYNC2I1

9.54e-04131052C0036996
DiseaseMigraine Disorders

LRP1 NOTCH3

9.54e-04131052C0149931
Diseaseobesity (implicated_via_orthology)

TCF3 ETV5 ITPR1 ZFHX3 NOTCH3

1.05e-032151055DOID:9970 (implicated_via_orthology)
DiseaseSaldino-Noonan Syndrome

IFT172 DYNC2I1

1.11e-03141052C0036069
DiseaseMajewski Syndrome

IFT172 DYNC2I1

1.11e-03141052C0024507
Diseaseinositol measurement

SETBP1 NOTCH3

1.11e-03141052EFO_0010504
Diseasehypertension (biomarker_via_orthology)

CHGA PKM FGF2 AKT2 IKBKB

1.33e-032271055DOID:10763 (biomarker_via_orthology)
DiseaseDementia

CST3 NOTCH3

1.65e-03171052C0497327
DiseaseMultiple congenital anomalies

POLD1 SETBP1

1.65e-03171052C0000772
Diseasebreast carcinoma (is_marker_for)

ABCE1 FGF2 ZFHX3

1.70e-03661053DOID:3459 (is_marker_for)
DiseaseOral Submucous Fibrosis

CST3 FGF2

1.85e-03181052C0029172
Diseasecolorectal cancer (is_marker_for)

TCF3 CTPS2 ZFHX3 AKT2

2.43e-031571054DOID:9256 (is_marker_for)
DiseaseDisease Exacerbation

IDH3B FGF2 ALDH7A1 VCP

2.91e-031651054C0235874

Protein segments in the cluster

PeptideGeneStartEntry
EIVGDVRGKGLMIGI

AGXT2

426

Q9BYV1
QRLGGGPSDAKEVME

AKT2

391

P31751
PGSEVLKVVAMDGDR

CDHR1

261

Q96JP9
GEGPERGRVKIADMG

CDK19

161

Q9BWU1
DAEGDIGKAEVMPVR

CRYBG3

1721

Q68DQ2
EGGTVVYGGKVMDRP

ALDH7A1

391

P49419
DVVIVERGKGDGVPE

CHAF1A

536

Q13111
AVVPEMEKRGGGSVV

DHRS4

151

Q9BTZ2
IMKGGAVAADGRIEP

DVL3

281

Q92997
KVEVDELGMGFRPGD

ARMCX2

301

Q7L311
LIVVGVGKPAEMRSG

NBEAL1

2651

Q6ZS30
EMCREEGGEGTPVKQ

MTCL1

1821

Q9Y4B5
GIGLVEEPMDKVEEG

RDM1

176

Q8NG50
AVVPEMEKRGGGSVV

DHRS4L2

151

Q6PKH6
KRREMDDGLAEGGPQ

LIN37

76

Q96GY3
AREVLDVAAGMIKPG

METAP1

146

P53582
VPGLGEMGKEETLTR

KIAA1671

16

Q9BY89
MDQEPVGGVERGEAV

FAM177A1

1

Q8N128
GGGPKRLGRDVEMEE

RPGRIP1L

96

Q68CZ1
PMGRKQGGTLDDLEE

IKBKB

551

O14920
MLKPGGQVDGDEALE

ITPR1

2181

Q14643
MGGAVVDEGPTGVKA

SLC16A3

1

O15427
GIIRGMDMGAKVPDE

LRP1

536

Q07954
EKEMLDGGVPGTTVR

FAM182A

36

Q5T1J6
RLVAMAAVGEPEKAG

DYNC2I1

1001

Q8WVS4
DGVLKPEGGGMLSEE

KIF27

1246

Q86VH2
GGDVDVRELLPGSVM

IFI35

166

P80217
GKEIIGGMLDIEPRL

CWF19L2

846

Q2TBE0
RLKVEEPGMGAEEAV

NOTCH3

1731

Q9UM47
EEVGQGMPLVSEGDR

NES

1561

P48681
MVARGDLGIEIPAEK

PKM

291

P14618
DGIMVARGDLGIEIP

PKLR

331

P30613
GRGMEFKLIEPEEVA

ETV5

391

P41161
SVREETGMGDIPDVK

LRRC8E

346

Q6NSJ5
EDEIPVVAIMATGGG

PLA2G4B

291

P0C869
PGDLVVREGSVGRKM

HCN3

451

Q9P1Z3
KGPELMAIEGLENGE

CASKIN2

641

Q8WXE0
PEGAIMGDVKVEDGA

NLRC5

191

Q86WI3
DVIGLERGGGKTEVM

IFT172

566

Q9UG01
GGDVELPRELAKMIE

CPLX3

96

Q8WVH0
MLAGRLKPDEGGEVP

ABCE1

391

P61221
GDGVGPELMHAVKEV

IDH3B

56

O43837
GVGEPVELDKGVRAM

IGSF22

881

Q8N9C0
IAGKILEMDDPRAVG

SLC1A7

276

O00341
MKAGRVVVADPQAGG

CRYBG2

1551

Q8N1P7
VKVLEEDPMVGGVGG

HAS2

226

Q92819
KVPEKMVVIGAGVIG

DLD

211

P09622
FPMELGIRVGLGKED

EFHB

26

Q8N7U6
MVGVGGGDVEDVTPR

FGF2

1

P09038
GKRQGGQMVDDVELP

NSMAF

466

Q92636
LDVMGALRKEGEPGS

ITGA7

36

Q13683
KGERRMEDEGGFPVP

FAM83H

976

Q6ZRV2
QRDPGETVGGDEIVM

CASP14

136

P31944
GEGPERGRVKIADMG

CDK8

161

P49336
GVEDGQTVRMPVGKR

DNAJA3

311

Q96EY1
MEKLGVEPEEEGGGD

POLI

1

Q9UNA4
GGRLGEAEGLMKVEA

SLC38A10

411

Q9HBR0
EGLLMPVVKSEGGED

POLD1

566

P28340
VGGPMDASVEEEGVR

CST3

36

P01034
ELMIPGGAKVIDATG

DPYSL5

41

Q9BPU6
GKMPIDLVIEDRDGG

MEIS3P1

66

A6NDR6
VEPVGMLKEGDRVEI

MCAM

256

P43121
EQIKRGGDAGMPGIE

GOLM2

241

Q6P4E1
VGVGPKGEESMAARV

REXO4

251

Q9GZR2
VTPVKAGRLVVEMGG

MRPL16

151

Q9NX20
GFGMDEALKDPVGRE

RGS7

331

P49802
MEKEGVLTREDRPGG

SRRM3

96

A6NNA2
RDGLEVVVTPGAMGA

SEMA4F

611

O95754
EGEGQGPLIRVDMTI

TMEM132C

761

Q8N3T6
EPEEELQKGMGTVEG

TCOF1

1416

Q13428
GAGSEVEVDMFLRKP

SPATA31A6

846

Q5VVP1
GIRGPEDVAKMGITE

IARS1

101

P41252
LVVALGPGGVSMDEK

SURF4

251

O15260
GTPVKIGEGMLADFV

RACGAP1

341

Q9H0H5
IPRAESGGKGERMAD

SV2A

101

Q7L0J3
DTPGVKMIVVLGEIG

ACLY

706

P53396
MEGGGGIPLETLKEE

ATPSCKMT

1

Q6P4H8
AGITGMAERIPELGE

ACSL3

306

O95573
EEEMAVVPQGLFRGG

CHGA

306

P10645
GMAEEAERPGEKAGQ

SENP3

291

Q9H4L4
AEPEMDVRKRTGVAG

USE1

131

Q9NZ43
ELGGTIGDIEGMPFV

CTPS2

146

Q9NRF8
VAALRKMVAEEGGVP

USP43

306

Q70EL4
KMVAEEGGVPADEVI

USP43

311

Q70EL4
AGEIGEMKDGVPEGA

YBX3

261

P16989
EIPIEGLEFMGHGKE

TRIAP1

56

O43715
TLKPGDRIVEVDGMD

MPDZ

1201

O75970
REEEKVSGVVGDPQM

TCF3

621

P15923
GGMRAVEFKVVETDP

VCP

156

P55072
RDIEGMGVPEIKYGD

RYR3

336

Q15413
MDRISNGGLEEGKPV

UBA5

161

Q9GZZ9
MGKGERVEGPEVAAG

PRX

876

Q9BXM0
GMEVVKVGGPVYRIG

PFAS

446

O15067
MAGPRVEVDGSIMEG

RTCA

1

O00442
MLPQVGKDGVLRDGD

SOGA1

1351

O94964
GKVHGEEEMIPGSVL

EZH1

156

Q92800
TGDAGGREPMEEKLL

GTF3C4

656

Q9UKN8
EMDGFKPNEGVIIIG

YME1L1

466

Q96TA2
GEVVEGDPDKVLRML

TIMM44

406

O43615
AGDGPLVIMGEVRDG

WFIKKN1

496

Q96NZ8
GGKIQIEMETVPEAG

ZNF221

101

Q9UK13
EEDEEKGGRRIMGPR

UBN1

496

Q9NPG3
EGPGTGGREMVEEAI

PLEKHG2

256

Q9H7P9
KGVPGVKAERFEEGM

TYW1

461

Q9NV66
KGIPVGGERMEPEEE

SETBP1

46

Q9Y6X0
MDGIVPDIAVGTKRG

PTBP1

1

P26599
GRKMAAGDIGELLVP

USP13

16

Q92995
MEPGRGGTETVGKFE

ULK1

1

O75385
GKFSGIRMEGEEALP

ZFHX3

366

Q15911
GGSPVIEGVDDAKEM

MYO5A

291

Q9Y4I1