Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainAUTS2

FBRSL1 AUTS2

1.48e-053422IPR023246
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

NPC1 FBRSL1 IRAK1 TEAD2 PIK3C2B MYRF PPRC1 SPHK1 C2CD2 CIC

9.35e-071105441035748872
Pubmed

Pathological roles of the VEGF/SphK pathway in Niemann-Pick type C neurons.

NPC1 SPHK1

4.69e-06344225417698
Pubmed

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

FBRSL1 AUTS2 MAGED1 CIC

4.15e-0515244438360978
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

FBRSL1 IRAK1 C9orf40 PPP1R13L NUMBL UBR5 PIK3C2B IQSEC2

4.18e-05103844826673895
Pubmed

Proximity labeling reveals dynamic changes in the SQSTM1 protein network.

FBRSL1 AUTS2 IRAK1 MAGED1 PPP1R13L

5.33e-0532244539098523
Pubmed

A Pellino-2 variant is associated with constitutive NLRP3 inflammasome activation in a family with ocular pterygium-digital keloid dysplasia.

IRAK1 ROBO1

1.41e-041444236776133
Pubmed

Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population.

NPC1 SH2B1

1.41e-041444219851340
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

LARP1 MAGED1 PPP1R13L NUMBL RTN4

2.39e-0444444534795231
Pubmed

A crucial role for Arf6 in the response of commissural axons to Slit.

ROBO1 IQSEC2

2.64e-041944230674481
Pubmed

The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.

LARP1 ROBO1 PRPF8 RTN4

3.09e-0425644433397691
Pubmed

Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing.

PRPF8 UBR5

3.24e-042144212840015
Pubmed

Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.

LARP1 MAGED1 PRPF8 UBR5

3.47e-0426444432814769
Pubmed

CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.

IRAK1 MAGED1 UBR5

3.52e-0410844330166453
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

FBRSL1 AUTS2 LARP1 ISLR2 RTN4

5.32e-0452944514621295
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

LARP1 TEAD2 PRPF8 UBR5 CIC SH2B1

6.99e-0485744625609649
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

IRAK1 LARP1 PPP1R13L NUMBL RTN4

7.16e-0456544525468996
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

LARP1 NUMBL PIK3C2B CIC IQSEC2 KIAA0753

7.16e-0486144636931259
Pubmed

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.

LARP1 ROBO1 UBR5 C2CD2 RTN4

7.33e-0456844537774976
Pubmed

Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors.

ROBO1 TEAD2

8.55e-043444230504829
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

FBRSL1 MAGED1 UBR5 PIK3C2B CIC

8.56e-0458844538580884
Pubmed

Identification of intracellular proteins associated with the EBV-encoded nuclear antigen 5 using an efficient TAP procedure and FT-ICR mass spectrometry.

MAGED1 PRPF8 UBR5

9.33e-0415144318457437
Pubmed

TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.

AUTS2 IRAK1 LARP1 MAGED1 PPP1R13L PRPF8

1.02e-0392244627609421
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

NPC1 ROBO1 MAGED1 PRPF8 PPRC1 SH2B1 IQSEC2

1.07e-03128544735914814
Pubmed

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.

LARP1 ROBO1 PRPF8 RTN4

1.08e-0335844432460013
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

IRAK1 LARP1 PRPF8 NUMBL CIC RTN4

1.09e-0393444633916271
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

NPC1 IRAK1 CRELD1 MAGED1 UBR5 RTN4

1.14e-0394244631073040
Pubmed

LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.

LARP1 MAGED1 PPP1R13L PRPF8 UBR5

1.24e-0363944523443559
Pubmed

PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes.

FBRSL1 AUTS2

1.24e-034144222325352
CytobandEnsembl 112 genes in cytogenetic band chr19q13

SELENOV TEAD2 PPP1R15A PPP1R13L KCNC3 NUMBL GGN CIC SBK3

1.63e-061192449chr19q13
Cytoband19q13.2

SELENOV PPP1R15A GGN CIC

1.91e-0516444419q13.2
CytobandXp11.22

SHROOM4 IQSEC2

1.24e-0354442Xp11.22
CytobandEnsembl 112 genes in cytogenetic band chr17p13

SPEM2 PRPF8 KIAA0753

4.47e-03346443chr17p13
Cytoband9q34.3

SOHLH1 LINC02908

4.69e-031064429q34.3
CytobandEnsembl 112 genes in cytogenetic band chrXp11

SHROOM4 MAGED1 IQSEC2

5.67e-03377443chrXp11
Cytoband17p13.1

SPEM2 KIAA0753

5.77e-0311844217p13.1
Diseasevisceral adipose tissue measurement

NPC1 AUTS2 ROBO1 PIK3C2B SH2B1

5.83e-04481425EFO_0004765
Diseaseglucose measurement

FBRSL1 AUTS2 NCR3LG1 RTN4

2.06e-03380424EFO_0004468
Diseaseleukemia

PPP1R13L SPHK1

2.80e-0355422C0023418

Protein segments in the cluster

PeptideGeneStartEntry
LHRAPPSFPAPPPWP

FBRSL1

736

Q9HCM7
TPTPAPAWPAPPATP

ISLR2

316

Q6UXK2
PWPPEPAPAPAPELD

NUMBL

561

Q9Y6R0
PIWLQPSPPPQSSPP

CRELD1

26

Q96HD1
PPTPAWQPEIKPEPA

LARP1

301

Q6PKG0
LPPDWPLPPDWPLPT

MAGED1

406

Q9Y5V3
PLPPDWPLPTDWPLP

MAGED1

411

Q9Y5V3
PPPPPPALSEELPWG

JSRP1

106

Q96MG2
PILPVSPIWEPPPAT

NCR3LG1

421

Q68D85
WAPAPLPPVPPPVPS

IQSEC2

546

Q5JU85
PSFPTPPPWLKPGEL

AUTS2

801

Q8WXX7
PSQFPPPLETWKPPP

GGN

161

Q86UU5
PPLETWKPPPPLPSE

GGN

166

Q86UU5
VPSPASLWPPPPSPA

IRAK1

161

P51617
PPPLPPRASIWDTPP

PIK3C2B

156

O00750
PQPPPPPAPWTILGL

NPC1

251

O15118
QPWPPQSKPSQPRPP

CARD6

996

Q9BX69
EPGELKSWPIPPPVP

C2CD2

386

Q9Y426
LLPPWVDLKEPPPPS

LINC02908

106

Q6ZV77
LPSPPWSQQTPVPPP

C19orf54

41

Q5BKX5
WSQQTPVPPPLPLPP

C19orf54

46

Q5BKX5
EQPPPPPLWIRPPGV

C9orf40

26

Q8IXQ3
TKPQPPQPPPPWDQF

SBK3

261

P0C264
PQPPPPWDQFAPPAL

SBK3

266

P0C264
WPPVNEGPPKPPTEL

PPP1R13L

446

Q8WUF5
APFWSTVPPPPLPPA

PPRC1

991

Q5VV67
PPLWLSRAPPPSPPS

MLNR

206

O43193
IYVPGEKPPPPWAPP

PPP1R15A

511

O75807
WSQGLPLPPPPPPAA

NUTM2D

201

Q5VT03
QKPPEPQDLLPWEPP

RTL3

86

Q8N8U3
EPVWTPPAPAPAAPP

RTN4

156

Q9NQC3
PPSWKYSPNIRAPPP

SYNPO2L

796

Q9H987
PPLPPPPPPSWREFC

SH2B1

16

Q9NRF2
PQPPEPPSWTDPPQP

SH2B1

641

Q9NRF2
LPPFSEPSSLVPWPP

SOHLH1

216

Q5JUK2
KKAFPPPRPPPPNWE

SHROOM4

1096

Q9ULL8
SPLPPPTPSPPAWQA

TEAD2

206

Q15562
PPPAPAWIPTPVPTP

SELENOV

86

P59797
PWIPPNPTSPPASPK

KIAA0753

556

Q2KHM9
QPTPPAPPPLPETWT

CIC

1226

Q96RK0
FPPWIKPADTEPPPL

PRPF8

936

Q6P2Q9
PPPHRLPPNPSWVPV

SPEM2

281

Q0P670
NWADLLPPPPAHPPP

ROBO1

1181

Q9Y6N7
VEPPPSWKPQQMPPP

SPHK1

366

Q9NYA1
PVSPPIAPPSWVPDP

UBR5

1016

O95071
PTPPSPASDWPPLAP

UBALD1

146

Q8TB05
VWLPEPPRTDPPQPP

PSORS1C2

81

Q9UIG4
PPQDWRKPGPPSFLP

KCNC3

731

Q14003
AEEPLQDPNWPPPPP

KIAA1522

701

Q9P206
PLHPTRAPSPPWPPQ

MYRF

286

Q9Y2G1
LPTPDPPPEPSPTGW

GRIN2C

946

Q14957