Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Peptidase_A22B_SPP	SPPL2B SPPL2C	1.75e-04	5	79	2	IPR007369
Domain	Peptidase_A22B	SPPL2B SPPL2C	1.75e-04	5	79	2	PF04258
Domain	PSN	SPPL2B SPPL2C	3.66e-04	7	79	2	SM00730
Domain	Preselin/SPP	SPPL2B SPPL2C	3.66e-04	7	79	2	IPR006639
Domain	Dwarfin	SMAD6 SMAD7	4.87e-04	8	79	2	IPR013790
Domain	DWB	SMAD6 SMAD7	4.87e-04	8	79	2	SM00524
Domain	MH2	SMAD6 SMAD7	4.87e-04	8	79	2	PS51076
Domain	MH1	SMAD6 SMAD7	4.87e-04	8	79	2	PS51075
Domain	-	SMAD6 SMAD7	4.87e-04	8	79	2	3.90.520.10
Domain	MAD_homology_MH1	SMAD6 SMAD7	4.87e-04	8	79	2	IPR013019
Domain	MH2	SMAD6 SMAD7	4.87e-04	8	79	2	PF03166
Domain	SMAD_dom_Dwarfin-type	SMAD6 SMAD7	4.87e-04	8	79	2	IPR001132
Domain	MYTH4	MYO7A MYO15A	6.24e-04	9	79	2	PS51016
Domain	MyTH4_dom	MYO7A MYO15A	6.24e-04	9	79	2	IPR000857
Domain	MyTH4	MYO7A MYO15A	6.24e-04	9	79	2	PF00784
Domain	MyTH4	MYO7A MYO15A	6.24e-04	9	79	2	SM00139
Domain	MAD_homology1_Dwarfin-type	SMAD6 SMAD7	1.13e-03	12	79	2	IPR003619
Domain	DWA	SMAD6 SMAD7	1.13e-03	12	79	2	SM00523
Domain	MH1	SMAD6 SMAD7	1.13e-03	12	79	2	PF03165
Domain	Spectrin_alpha_SH3	SRGAP3 ITK	1.79e-03	15	79	2	IPR013315
Domain	SMAD_dom-like	SMAD6 SMAD7	2.04e-03	16	79	2	IPR017855
Domain	-	SMAD6 SMAD7	2.04e-03	16	79	2	2.60.200.10
Domain	SH3	NOXO1 MYO7A SRGAP3 MYO15A ITK	2.22e-03	216	79	5	SM00326
Domain	SH3	NOXO1 MYO7A SRGAP3 MYO15A ITK	2.22e-03	216	79	5	PS50002
Domain	SH3_domain	NOXO1 MYO7A SRGAP3 MYO15A ITK	2.41e-03	220	79	5	IPR001452
Domain	F-box	FBXO38 FBXO10 FBXO45	2.87e-03	67	79	3	PF00646
Domain	PA	SPPL2B SPPL2C	2.88e-03	19	79	2	PF02225
Domain	PA_domain	SPPL2B SPPL2C	2.88e-03	19	79	2	IPR003137
Domain	FBOX	FBXO38 FBXO10 FBXO45	3.52e-03	72	79	3	PS50181
Domain	F-box_dom	FBXO38 FBXO10 FBXO45	3.95e-03	75	79	3	IPR001810
Domain	IQ	MYO7A SCN7A MYO15A	4.90e-03	81	79	3	SM00015
Domain	IQ_motif_EF-hand-BS	MYO7A SCN7A MYO15A	6.57e-03	90	79	3	IPR000048
Pubmed	Inhibitory Smad proteins promote the differentiation of mouse embryonic stem cells into ependymal-like ciliated cells.	SMAD6 SMAD7	5.49e-06	2	82	2	20807502
Pubmed	Investigation of MYO15A and MYO7A Mutations in Iranian Patients with Nonsyndromic Hearing Loss.	MYO7A MYO15A	5.49e-06	2	82	2	31997689
Pubmed	Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis.	SMAD6 SMAD7	5.49e-06	2	82	2	20658468
Pubmed	Cy3-ATP labeling of unfixed, permeabilized mouse hair cells.	MYO7A MYO15A	5.49e-06	2	82	2	34903829
Pubmed	Inhibitory SMADs: potential regulators of ovarian function.	SMAD6 SMAD7	5.49e-06	2	82	2	25550343
Pubmed	Expressions of inhibitory Smads, Smad6 and Smad7, are differentially regulated by TPA in human lung fibroblast cells.	SMAD6 SMAD7	5.49e-06	2	82	2	15033458
Pubmed	A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk.	SMAD6 SMAD7	5.49e-06	2	82	2	17934461
Pubmed	Prognostic value of the expression of Smad6 and Smad7, as inhibitory Smads of the TGF-beta superfamily, in esophageal squamous cell carcinoma.	SMAD6 SMAD7	5.49e-06	2	82	2	15736400
Pubmed	Altered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC protein.	AICDA EDIL3	1.64e-05	3	82	2	22833677
Pubmed	Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia.	MYO7A MYO15A	1.64e-05	3	82	2	15654330
Pubmed	Polg2 is essential for mammalian embryogenesis and is required for mtDNA maintenance.	POLG EDIL3	1.64e-05	3	82	2	23197651
Pubmed	Minor contribution of SMAD7 and KLF10 variants to genetic susceptibility of type 2 diabetes.	SMAD6 SMAD7	1.64e-05	3	82	2	17931948
Pubmed	Genetic susceptibility to keloid scarring: SMAD gene SNP frequencies in Afro-Caribbeans.	SMAD6 SMAD7	1.64e-05	3	82	2	18445023
Pubmed	Bone morphogenetic protein and transforming growth factor beta inhibitory Smads 6 and 7 are expressed in human adult normal and osteoarthritic cartilage in vivo and are differentially regulated in vitro by interleukin-1beta.	SMAD6 SMAD7	1.64e-05	3	82	2	15529348
Pubmed	Hsa-miR-186-5p regulates TGFβ signaling pathway through expression suppression of SMAD6 and SMAD7 genes in colorectal cancer.	SMAD6 SMAD7	1.64e-05	3	82	2	33938174
Pubmed	Inhibitory smads and tgf-Beta signaling in glomerular cells.	SMAD6 SMAD7	1.64e-05	3	82	2	12397035
Pubmed	Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling.	SMAD6 SMAD7	1.64e-05	3	82	2	12118366
Pubmed	Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development.	LATS1 DCHS1 EDIL3	3.16e-05	26	82	3	21303848
Pubmed	Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly.	MYO7A MYO15A	3.28e-05	4	82	2	15590698
Pubmed	Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation.	MYO7A MYO15A	3.28e-05	4	82	2	30275467
Pubmed	Myo15 function is distinct from Myo6, Myo7a and pirouette genes in development of cochlear stereocilia.	MYO7A MYO15A	3.28e-05	4	82	2	12966030
Pubmed	Heterogeneity of Hereditary Hearing Loss in Iran: a Comprehensive Review.	MYO7A MYO15A	3.28e-05	4	82	2	27743438
Pubmed	Smad6 inhibits signalling by the TGF-beta superfamily.	SMAD6 SMAD7	3.28e-05	4	82	2	9335505
Pubmed	Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7.	SMAD6 SMAD7	3.28e-05	4	82	2	11737269
Pubmed	Downregulation of ZEB1 and overexpression of Smad7 contribute to resistance to TGF-beta1-mediated growth suppression in adult T-cell leukemia/lymphoma.	SMAD6 SMAD7	3.28e-05	4	82	2	20514018
Pubmed	Modulation of thrombomodulin-dependent activation of human protein C through differential expression of endothelial Smads.	SMAD6 SMAD7	3.28e-05	4	82	2	12407115
Pubmed	[Na+] Increases in Body Fluids Sensed by Central Nax Induce Sympathetically Mediated Blood Pressure Elevations via H+-Dependent Activation of ASIC1a.	SLC32A1 SCN7A	3.28e-05	4	82	2	30503172
Pubmed	The role of mouse mutants in the identification of human hereditary hearing loss genes.	MYO7A MYO15A	3.28e-05	4	82	2	10320095
Pubmed	Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins.	SPPL2B SPPL2C	5.47e-05	5	82	2	15385547
Pubmed	Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape.	MYO7A MYO15A	5.47e-05	5	82	2	20332152
Pubmed	SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production.	SPPL2B SPPL2C	5.47e-05	5	82	2	16829952
Pubmed	Developmentally regulated expression of Smad3, Smad4, Smad6, and Smad7 involved in TGF-beta signaling.	SMAD6 SMAD7	5.47e-05	5	82	2	11231077
Pubmed	FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor.	SMAD6 SMAD7	5.47e-05	5	82	2	16720724
Pubmed	Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases.	SMAD6 SMAD7	5.47e-05	5	82	2	15817471
Pubmed	Novel class of polytopic proteins with domains associated with putative protease activity.	SPPL2B SPPL2C	5.47e-05	5	82	2	12139484
Pubmed	Endothelial RSPO3 Controls Vascular Stability and Pruning through Non-canonical WNT/Ca(2+)/NFAT Signaling.	RNF213 EDIL3	5.47e-05	5	82	2	26766444
Pubmed	Distinct neural mechanisms for the control of thirst and salt appetite in the subfornical organ.	SLC32A1 SCN7A	5.47e-05	5	82	2	27991901
Pubmed	Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia.	MYO7A MYO15A	5.47e-05	5	82	2	18160714
Pubmed	Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads.	SMAD6 SMAD7	5.47e-05	5	82	2	11483516
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	CNPPD1 FLII ABCC3 KMT2B MYO7A POLG CACFD1 SPPL2B RALGAPA2 HECTD1 SMAD7	5.65e-05	1105	82	11	35748872
Pubmed	Smad7 Inhibits chondrocyte differentiation at multiple steps during endochondral bone formation and down-regulates p38 MAPK pathways.	SMAD6 SMAD7	8.19e-05	6	82	2	18644788
Pubmed	Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6.	SMAD6 SMAD7	8.19e-05	6	82	2	23455153
Pubmed	Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium.	SMAD6 SMAD7	8.19e-05	6	82	2	9256479
Pubmed	Genomics and hearing impairment.	MYO7A MYO15A	8.19e-05	6	82	2	9927480
Pubmed	SMAD expression in the testis: an insight into BMP regulation of spermatogenesis.	SMAD6 SMAD7	8.19e-05	6	82	2	18069690
Pubmed	Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload.	SMAD6 SMAD7	8.19e-05	6	82	2	22960056
Pubmed	Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7.	SMAD6 SMAD7	1.14e-04	7	82	2	14657019
Pubmed	Tails of unconventional myosins.	MYO7A MYO15A	1.14e-04	7	82	2	11212352
Pubmed	Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b.	SPPL2B SPPL2C	1.14e-04	7	82	2	17965014
Pubmed	Deficiency of large tumor suppressor kinase 1 causes congenital hearing loss associated with cochlear abnormalities in mice.	LATS1 MYO7A	1.14e-04	7	82	2	33162027
Pubmed	Can't get no SMADisfaction: Smad proteins as positive and negative regulators of TGF-beta family signals.	SMAD6 SMAD7	1.14e-04	7	82	2	10376010
Pubmed	Myosins: a diverse superfamily.	MYO7A MYO15A	1.14e-04	7	82	2	10722873
Pubmed	Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3.	SMAD6 SMAD7	1.14e-04	7	82	2	12815042
Pubmed	STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling.	SMAD6 SMAD7	1.14e-04	7	82	2	10757800
Pubmed	Innervation of nociceptor neurons in the spleen promotes germinal center responses and humoral immunity.	RAMP1 AICDA	1.14e-04	7	82	2	38772371
Pubmed	Organ of Corti size is governed by Yap/Tead-mediated progenitor self-renewal.	LATS1 MYO7A	1.14e-04	7	82	2	32482884
Pubmed	Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia.	MYO7A MYO15A	1.14e-04	7	82	2	21436032
Pubmed	[Studies on the genetics and pathology of the development of 8 labyrinth mutants (deaf-waltzer-shaker mutants) in the mouse (Mus musculus)].	MYO7A MYO15A	1.14e-04	7	82	2	13853422
Pubmed	Impact of WIN site inhibitor on the WDR5 interactome.	ZNF462 KMT2B HELB	1.46e-04	43	82	3	33472061
Pubmed	Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells.	SMAD6 SMAD7	1.52e-04	8	82	2	10647776
Pubmed	The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation.	SMAD6 SMAD7	1.52e-04	8	82	2	15359284
Pubmed	Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation.	SMAD6 SMAD7	1.52e-04	8	82	2	11278251
Pubmed	Smad7 inhibits transforming growth factor-beta family type i receptors through two distinct modes of interaction.	SMAD6 SMAD7	1.52e-04	8	82	2	20663871
Pubmed	TGF-beta signaling by Smad proteins.	SMAD6 SMAD7	1.52e-04	8	82	2	10708949
Pubmed	Normal lytic granule secretion by cytotoxic T lymphocytes deficient in BLOC-1, -2 and -3 and myosins Va, VIIa and XV.	MYO7A MYO15A	1.52e-04	8	82	2	15702992
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZNF462 PTDSS1 RNF213 DDHD2 RALGAPA2 HECTD1 DENND3	1.68e-04	493	82	7	15368895
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	ZNF462 FBXO38 FBXO10 KMT2B GALNT8 FBXO45 HELB	1.72e-04	495	82	7	27705803
Pubmed	Holding their own: the noncanonical roles of Smad proteins.	SMAD6 SMAD7	1.96e-04	9	82	2	19018011
Pubmed	TGF-beta signal transduction.	SMAD6 SMAD7	1.96e-04	9	82	2	9759503
Pubmed	Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia.	SMAD6 SMAD7	1.96e-04	9	82	2	16601693
Pubmed	Smad7 Protein Interacts with Receptor-regulated Smads (R-Smads) to Inhibit Transforming Growth Factor-β (TGF-β)/Smad Signaling.	SMAD6 SMAD7	1.96e-04	9	82	2	26555259
Pubmed	The Smad pathway.	SMAD6 SMAD7	1.96e-04	9	82	2	10708948
Pubmed	Multiplexed peroxidase-based electron microscopy labeling enables simultaneous visualization of multiple cell types.	SLC32A1 MRGPRX2	1.96e-04	9	82	2	30886406
Pubmed	Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea.	MYO7A MYO15A	1.96e-04	9	82	2	19339464
Pubmed	NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor.	SMAD6 SMAD7	1.96e-04	9	82	2	15496141
Pubmed	Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain.	UBR1 XPC HECTD1	2.29e-04	50	82	3	17550899
Pubmed	Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.	SRGAP3 MYO15A ITK	2.29e-04	50	82	3	19807924
Pubmed	Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).	SMAD6 SMAD7	2.44e-04	10	82	2	15221015
Pubmed	Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor.	SMAD6 SMAD7	2.44e-04	10	82	2	9436979
Pubmed	Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity.	SMAD6 SMAD7	2.44e-04	10	82	2	16890162
Pubmed	Spatio-temporal distribution of Smads and role of Smads/TGF-β/BMP-4 in the regulation of mouse bladder organogenesis.	SMAD6 SMAD7	2.44e-04	10	82	2	23620745
Pubmed	Genetic and Molecular Analyses indicate independent effects of TGIFs on Nodal and Gli3 in neural tube patterning.	EDIL3 SMAD7	2.44e-04	10	82	2	27924807
Pubmed	Tulp3 Regulates Renal Cystogenesis by Trafficking of Cystoproteins to Cilia.	GPR161 INPP5A	2.44e-04	10	82	2	30799239
Pubmed	Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.	SMAD6 SMAD7	2.98e-04	11	82	2	19758997
Pubmed	Loss of Atoh1 from neurons regulating hypoxic and hypercapnic chemoresponses causes neonatal respiratory failure in mice.	SLC32A1 EDIL3	2.98e-04	11	82	2	29972353
Pubmed	Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity.	LATS1 SMAD7	2.98e-04	11	82	2	25283809
Pubmed	Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.	FBXO38 FBXO10 FBXO45	3.03e-04	55	82	3	37028429
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	P2RX2 SCN7A SCNN1B KCNN2	3.36e-04	139	82	4	16985003
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	NOXO1 FBXO10 KMT2B MYO7A SRGAP3 RNF213 GAL3ST2 FAM186B	3.48e-04	736	82	8	29676528
Pubmed	Reciprocal Negative Regulation Between Lmx1a and Lmo4 Is Required for Inner Ear Formation.	MYO7A MYO15A	3.57e-04	12	82	2	29769265
Pubmed	CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.	MYO7A MYO15A	3.57e-04	12	82	2	28663585
Pubmed	Smad expression during kidney development.	SMAD6 SMAD7	3.57e-04	12	82	2	14656760
Pubmed	High-throughput mapping of a dynamic signaling network in mammalian cells.	NOXO1 PRPF4 ITK SMAD6 SMAD7	3.84e-04	260	82	5	15761153
Pubmed	Systematic analysis and nomenclature of mammalian F-box proteins.	FBXO38 FBXO10 FBXO45	4.12e-04	61	82	3	15520277
Pubmed	A physical map of the mouse shaker-2 region contains many of the genes commonly deleted in Smith-Magenis syndrome (del17p11.2p11.2).	FLII MYO15A	4.21e-04	13	82	2	10049592
Pubmed	TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs.	SMAD6 SMAD7	4.21e-04	13	82	2	18095342
Pubmed	Molecular markers of cardiac endocardial cushion development.	EDIL3 SMAD6	4.21e-04	13	82	2	14648841
Pubmed	Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1.	UBR1 TMEM87A	4.21e-04	13	82	2	12434312
Pubmed	Composition and Regulation of the Cellular Repertoire of SCF Ubiquitin Ligases.	FBXO38 FBXO10 FBXO45	4.32e-04	62	82	3	29103612
Pubmed	Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3.	SMAD6 SMAD7	4.91e-04	14	82	2	11854453
Interaction	USP15 interactions	UBR1 FLII LATS1 AICDA PRPF4 RNF213 XPC FBXO45 HECTD1 SMAD6 SMAD7	8.92e-06	546	79	11	int:USP15
GeneFamily	Cyclins\|F-boxes other	FBXO38 FBXO10 FBXO45	2.50e-04	39	57	3	560
GeneFamily	SMAD family	SMAD6 SMAD7	2.70e-04	8	57	2	750
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	PGGHG RNF213 ITK HELB CRY1	1.03e-05	156	82	5	1545169694f686d28648a68b552c2ae606599d66
ToppCell	390C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	RAMP1 KCNN2 ABHD16A ITK PGBD2	1.57e-05	170	82	5	a6fa0cab1fa829ec601fe48306b4c43c83425b04
ToppCell	390C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	RAMP1 KCNN2 ABHD16A ITK PGBD2	1.57e-05	170	82	5	b40255eee45eb18b5a297336d7f3845fd8f8aa3b
ToppCell	droplet-Heart-4Chambers-18m-Endothelial-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRDM11 KCTD19 TIMP4 DENND3	1.94e-05	86	82	4	d20ec61a572b11641647358a546334b217c694f3
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF462 SRGAP3 STK32B XKR4 EDIL3	2.54e-05	188	82	5	63a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	CNPPD1 PRPF4 CACFD1 TARBP1 PGBD2	2.67e-05	190	82	5	651a1d3ae286e40f9d9f60e438211c6148d24143
ToppCell	ILEUM-non-inflamed-(8)_Activated_fibroblasts\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ZNF462 ABCC3 PRDM11 SLC26A6 SMAD6	2.67e-05	190	82	5	39fa110d19c97c7cac99f5fb91b26bc08e2f3b42
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF462 ABCC3 SRGAP3 XKR4 EDIL3	2.74e-05	191	82	5	d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCell	droplet-Lung-1m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ABCC3 TMEM204 SCN7A EDIL3 SMAD6	2.81e-05	192	82	5	ff435141329e3e29fa9b08a4d5b2f55074e7f9ab
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM204 RALGAPA2 DENND3 SMAD6 SMAD7	2.81e-05	192	82	5	2bfac6b3956265205ca47d06888851ed68b65999
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM204 RALGAPA2 DENND3 SMAD6 SMAD7	2.81e-05	192	82	5	d525f7f088a53110912600a7c9f6d33b9270d534
ToppCell	droplet-Lung-18m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ABCC3 TMEM204 INPP5A EDIL3 SMAD6	2.88e-05	193	82	5	25129080f8a40b2988a5d9dfec36ff9e72c27e61
ToppCell	droplet-Lung-21m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ABCC3 TMEM204 SCN7A EDIL3 SMAD6	2.88e-05	193	82	5	3a5ad8ffad441e30a6e1bd017da7720ad57f6c57
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM204 RALGAPA2 DENND3 SMAD6 SMAD7	2.95e-05	194	82	5	c8b9551b93a5aed62154b487db90130604a6125c
ToppCell	droplet-Lung-nan-18m-Endothelial-Capillary_Aerocyte_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC3 TMEM204 INPP5A EDIL3 SMAD6	2.95e-05	194	82	5	f35f03412b596b6b570b377ba1a607409d984bb1
ToppCell	PND03-Endothelial-Endothelial_blood-vessel\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TMEM204 SCN7A EDIL3 SMAD6 SMAD7	2.95e-05	194	82	5	f93f5148b136819d87faef89707dbaba07d6c2b5
ToppCell	PND03-Endothelial\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TMEM204 SCN7A EDIL3 SMAD6 SMAD7	3.10e-05	196	82	5	a529681d822a95dd1980b7b1c71dc61aaf0baecd
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM204 MYO7A INPP5A RALGAPA2 SMAD6	3.10e-05	196	82	5	81900dcc9451ff6606ec940c16b559d73247590e
Disease	generalized anxiety disorder (implicated_via_orthology)	ZNF462 HTR1E	1.96e-04	8	79	2	DOID:14320 (implicated_via_orthology)
Disease	nephritis (biomarker_via_orthology)	SMAD6 SMAD7	3.83e-04	11	79	2	DOID:10952 (biomarker_via_orthology)
Disease	dystonia (is_implicated_in)	KMT2B KCNN2	6.31e-04	14	79	2	DOID:543 (is_implicated_in)
Disease	Nonsyndromic genetic hearing loss	MYO7A P2RX2 MYO15A	1.13e-03	76	79	3	cv:C5680182
Disease	Craniosynostosis	ZNF462 SMAD6	1.30e-03	20	79	2	C0010278
Disease	Nonsyndromic Deafness	MYO7A P2RX2 MYO15A	1.36e-03	81	79	3	C3711374
Disease	thyroid stimulating hormone measurement	PRDM11 SCNN1B RAB20 XKR4 SMAD6	1.77e-03	323	79	5	EFO_0004748
Disease	colon carcinoma	PI15 SMAD7	2.21e-03	26	79	2	EFO_1001950
Disease	Alzheimer disease, age at onset	AICDA DCHS1 KCNN2 HYI SPPL2C	2.30e-03	343	79	5	EFO_0004847, MONDO_0004975

Protein segments in the cluster

Peptide	Gene	Start	Entry
LCCVRISEDKWWYRV	TDRD5	531	Q8NAT2
RAWYELILSLDSTRW	FBXO10	31	Q9UK96
WYRWLCRLSGVLGAV	CACFD1	26	Q9UGQ2
YSRWEVEEDWCLSVL	ABHD16A	486	O95870
DRWKLGYFLCEVWLS	HTR1E	86	P28566
SDWDLDPGRCYRVTW	AICDA	66	Q9GZX7
AEWITYRTWIESLSR	CFAP46	701	Q8IYW2
CRIWQFGRWVEVTTD	CAPN10	111	Q9HC96
LRWLGDWGDTLTYEI	FAM186B	101	Q8IYM0
ECVVGWSRRSRHWYS	C1orf147	241	Q96MC9
WAACAGRSEVYIWSL	DENND3	1091	A2RUS2
WRSYNISIWDTAGRE	RAB20	46	Q9NX57
WCDWGRTIRSYRELA	RAMP1	56	O60894
VAERASLNYWRTWKC	KCTD19	121	Q17RG1
LGVLLWCVSWADLFY	ABCC3	76	O15438
ERLWNVSCELLGIRW	RDH12	301	Q96NR8
ELRGSYNWDYLLSWC	DCHS1	3156	Q96JQ0
YILDCWSDVFIWLGR	FLII	776	Q13045
ATVWDRYSWCAVALA	DOLK	36	Q9UPQ8
NTRWDYCVRAKRGWT	KIAA0895	416	Q8NCT3
VLLRTGYTQLCDWWS	LATS1	921	O95835
SLRWSCLWLRADAYG	MYO15A	1151	Q9UKN7
LRAEWRCQVEGALLW	MYO15A	1971	Q9UKN7
LWIIAAWTVRACERY	KCNN2	321	Q9H2S1
IQDYWWSVDRLATCS	ADAMTSL1	1486	Q8N6G6
WSRKGFIRTRWCIAD	INPP5A	161	Q14642
LRERKTISWWGCYSQ	OR4K13	86	Q8NH42
VYWDELASEVRRCTW	DDHD2	101	O94830
GLRWYRLSDEGEWLV	POLG	991	P54098
SRLYWSTVDARRRCW	KMT2B	1761	Q9UMN6
GWDVVRAVAEFWCSR	PGGHG	396	Q32M88
WIRANLCVYISRELW	RALGAPA2	606	Q2PPJ7
RLARGCWSALWDYET	P2RX2	16	Q9UBL9
VRVVDLCAGRWWEYM	FBXO38	71	Q6PIJ6
RARSWCALDWRLYEH	GAL3ST2	271	Q9H3Q3
WSWYGRITLRSELLG	EDIL3	461	O43854
RRRLYYGWDWEADCS	CNPPD1	36	Q9BV87
YHWRDWSIIRGRDCL	HECTD1	661	Q9ULT8
WSIIRGRDCLYIWSD	HECTD1	666	Q9ULT8
TVEGLSWLRSYWDRR	HYI	256	Q5T013
WYRCLHGDENSEVWR	FBXO45	66	P0C2W1
LWCRYDALPQAWIDL	GALNT8	331	Q9NY28
VACFLTRGDLWISWE	CRY1	361	Q16526
RGWLVRRLCYFLWSL	GPAT2	86	Q6NUI2
CASRYSDVWIALIWG	GPR156	216	Q8NFN8
TSSIRREWIFGVVWC	GPR161	86	Q8N6U8
ALVCWQWGIFIRTYL	SCNN1B	61	P51168
ELRQRYCLDTWGVWP	DPP7	376	Q9UHL4
TYREWKLLRCEASWI	HELB	261	Q8NG08
EEYCLLDSSEIHWWR	ITK	196	Q08881
WCSVAYWEHRTRVGR	SMAD6	331	O43541
SLARWLLCNGSLRWY	TMEM161B	26	Q8NDZ6
RFLGTTCYDRSWRLW	PRPF4	336	O43172
TCYDRSWRLWDLEAQ	PRPF4	341	O43172
WRTWLQCSRARAYAL	SLC26A6	56	Q9BXS9
CRDIRPGEWLRVWYS	PRDM11	246	Q9NQV5
RWAWLLQDTLGISYC	SPPL2C	346	Q8IUH8
IWGSSWEVSERIREC	SMIM23	51	A6NLE4
CIWEGWTLESEALRR	IL9R	6	Q01113
LEISVYWRDWRSLCA	PKN2	431	Q16513
ERCLSVLWPIWYRCR	MRGPRX2	126	Q96LB1
VLETSDRGWWLCRYG	NOXO1	266	Q8NFA2
IWCGTTSRGYLVWFE	PGBD2	296	Q6P3X8
LELWLATWLGVFYCA	TAS2R1	91	Q9NYW7
ARRWKGLERVHWYTC	RNF213	4491	Q63HN8
WCVVAYWEEKTRVGR	SMAD7	261	O15105
ILVERFLWDGLWYCR	ZNF135	111	P52742
CDYRSEGWWTLLTSV	TRAPPC11	481	Q7Z392
LLLYHRASEDWWEGR	SRGAP3	771	O43295
CAVALWRRELGVFWT	SPPL2B	486	Q8TCT7
EYWDTVRPLLQRWCA	UBR1	1556	Q8IWV7
GREQRRYSLWDCLWI	XKR4	101	Q5GH76
RYSLWDCLWILAAVA	XKR4	106	Q5GH76
CLWTDWLLERKLYGY	TIMP4	176	Q99727
LICRGLDYFSSLWIW	TMEM245	181	Q9H330
RFLSYEDLICWQIWE	ZNF233	96	A6NK53
EWCSYQTPRRERWCD	ZNF462	246	Q96JM2
RSVGLWRSCWLVDRT	TMEM204	41	Q9BSN7
VFRILCGEWVETLWD	SCN7A	681	Q01118
VDWWSLGITAYELLR	STK32B	206	Q9NY57
VIAYCLSRARDWAWE	SLC32A1	281	Q9H598
VWGSVWRRAVYLVCN	PI15	196	O43692
LWTELCDWLRVNESY	TARBP1	571	Q13395
CRVDAEWWAETLRPY	XPC	596	Q01831
LLWDRFVRGCRADWY	THAP10	31	Q9P2Z0
YGLCWTISITWELTE	PTDSS1	186	P48651
AWSACYWRDLLRIQF	TMEM87A	246	Q8NBN3
IRYSEERGWELLWLC	MYO7A	1826	Q13402