Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	CUL2 PRAMEF14 PRAMEF20 PRAMEF13	4.35e-05	47	87	4	GO:0031462
GeneOntologyCellularComponent	CAF-1 complex	CHAF1B CHAF1A	5.12e-05	3	87	2	GO:0033186
Domain	WH2	WAS WASHC1 WASH2P MTSS2	4.35e-06	24	87	4	PS51082
Domain	zf-C2H2_6	HIC1 ZNF532 ZNF432 ZNF615 ZNF700 ZNF763 ZNF791	6.57e-04	314	87	7	PF13912
Domain	ZINC_FINGER_C2H2_2	BNC2 HIC1 ZNF532 GLI2 ZNF432 ZNF407 HIC2 ZNF615 ZNF700 ZNF763 ZNF791	9.25e-04	775	87	11	PS50157
Domain	ZINC_FINGER_C2H2_1	BNC2 HIC1 ZNF532 GLI2 ZNF432 ZNF407 HIC2 ZNF615 ZNF700 ZNF763 ZNF791	9.44e-04	777	87	11	PS00028
Domain	Znf_C2H2-like	BNC2 HIC1 ZNF532 GLI2 ZNF432 ZNF407 HIC2 ZNF615 ZNF700 ZNF763 ZNF791	1.15e-03	796	87	11	IPR015880
Domain	-	HIC1 ZNF532 GLI2 ZNF432 ZNF407 HIC2 ZNF615 ZNF700 ZNF763 ZNF791	1.21e-03	679	87	10	3.30.160.60
Domain	Znf_C2H2	BNC2 HIC1 ZNF532 GLI2 ZNF432 ZNF407 HIC2 ZNF615 ZNF700 ZNF763 ZNF791	1.26e-03	805	87	11	IPR007087
Domain	ZnF_C2H2	BNC2 HIC1 ZNF532 GLI2 ZNF432 ZNF407 HIC2 ZNF615 ZNF700 ZNF763 ZNF791	1.29e-03	808	87	11	SM00355
Domain	zf-C2H2	BNC2 HIC1 GLI2 ZNF432 ZNF407 HIC2 ZNF615 ZNF700 ZNF763 ZNF791	1.41e-03	693	87	10	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	HIC1 ZNF532 GLI2 ZNF432 ZNF407 HIC2 ZNF615 ZNF700 ZNF763 ZNF791	1.43e-03	694	87	10	IPR013087
Domain	PRAME_family	PRAMEF20 PRAMEF13	3.48e-03	19	87	2	IPR026271
Domain	WH2_dom	WAS WASH2P	4.25e-03	21	87	2	IPR003124
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TRIM66 SETDB1 CHAF1B CECR2 CHAF1A SEC16A MTR MACF1 HIC2 RFC3 WWC1 NSMCE1 WDR72	5.24e-06	1116	89	13	31753913
Pubmed	CHAF1A/B mediate silencing of unintegrated HIV-1 DNAs early in infection.	CHAF1B CHAF1A	6.48e-06	2	89	2	35074917
Pubmed	Hepatic cytochrome P450 reductase-null mice reveal a second microsomal reductase for squalene monooxygenase.	SQLE POR	6.48e-06	2	89	2	17374357
Pubmed	CAF-1 and the inheritance of chromatin states: at the crossroads of DNA replication and repair.	CHAF1B CHAF1A	6.48e-06	2	89	2	10893180
Pubmed	New insights into cellular cholesterol acquisition: promoter analysis of human HMGCR and SQLE, two key control enzymes in cholesterol synthesis.	SQLE HMGCR	6.48e-06	2	89	2	28342963
Pubmed	The p150 and p60 subunits of chromatin assembly factor I: a molecular link between newly synthesized histones and DNA replication.	CHAF1B CHAF1A	6.48e-06	2	89	2	7600578
Pubmed	Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1.	HIC1 HIC2	6.48e-06	2	89	2	11554746
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF14 PRAMEF20 PRAMEF13	1.29e-05	18	89	3	23894331
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF14 PRAMEF20 PRAMEF13	1.29e-05	18	89	3	12890732
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF14 PRAMEF20 PRAMEF13	1.29e-05	18	89	3	29731491
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF14 PRAMEF20 PRAMEF13	1.29e-05	18	89	3	14675769
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF14 PRAMEF20 PRAMEF13	1.52e-05	19	89	3	28604677
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	PWP1 TRIM66 SETDB1 MDN1 PRAMEF14 PRAMEF20 SQLE TNFAIP1 PRAMEF13 ZNF791 ADCY2 MTSS2 C1orf174	1.63e-05	1242	89	13	30973865
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF14 PRAMEF20 PRAMEF13	1.79e-05	20	89	3	26694250
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF14 PRAMEF20 PRAMEF13	1.79e-05	20	89	3	16580637
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF14 PRAMEF20 PRAMEF13	1.79e-05	20	89	3	21425410
Pubmed	Nucleosome assembly activity and intracellular localization of human CAF-1 changes during the cell division cycle.	CHAF1B CHAF1A	1.94e-05	3	89	2	9614144
Pubmed	The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway.	SQLE HMGCR	1.94e-05	3	89	2	24449766
Pubmed	Mechanism suppressing H3K9 trimethylation in pluripotent stem cells and its demise by polyQ-expanded huntingtin mutations.	SETDB1 HTT	1.94e-05	3	89	2	30452683
Pubmed	PTPN14 is required for the density-dependent control of YAP1.	CUL2 CSNK1D WWC1	2.08e-05	21	89	3	22948661
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF14 PRAMEF20 PRAMEF13	2.41e-05	22	89	3	31729367
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF14 PRAMEF20 PRAMEF13	2.76e-05	23	89	3	19480014
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF14 PRAMEF20 PRAMEF13	3.58e-05	25	89	3	37451217
Pubmed	Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.	PRAMEF14 PRAMEF20 PRAMEF13	3.58e-05	25	89	3	12620990
Pubmed	Common variations in 4p locus are related to male completed suicide.	EVC HTT	3.87e-05	4	89	2	19115052
Pubmed	A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose.	BNC2 WDR72	3.87e-05	4	89	2	19875614
Pubmed	New histone incorporation marks sites of UV repair in human cells.	CHAF1B CHAF1A	3.87e-05	4	89	2	17081972
Pubmed	Evaluation of four novel genetic variants affecting hemoglobin A1c levels in a population-based type 2 diabetes cohort (the HUNT2 study).	BNC2 WDR72	3.87e-05	4	89	2	21294870
Pubmed	Inactivation of Rho GTPases by Burkholderia cenocepacia Induces a WASH-Mediated Actin Polymerization that Delays Phagosome Maturation.	WAS WASHC1	3.87e-05	4	89	2	32492429
Pubmed	Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway.	CHAF1B CHAF1A	3.87e-05	4	89	2	11897662
Pubmed	The methyl-CpG binding protein MBD1 interacts with the p150 subunit of chromatin assembly factor 1.	CHAF1B CHAF1A	3.87e-05	4	89	2	12697822
Pubmed	The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif.	HIC1 HIC2	3.87e-05	4	89	2	12052894
Pubmed	A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome.	SQLE HMGCR	3.87e-05	4	89	2	23892605
Pubmed	Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4.	CHAF1B CHAF1A	3.87e-05	4	89	2	8858152
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF14 PRAMEF20 PRAMEF13	4.04e-05	26	89	3	18500982
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF14 PRAMEF20 PRAMEF13	5.07e-05	28	89	3	25089626
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF14 PRAMEF20 PRAMEF13	6.26e-05	30	89	3	38786026
Pubmed	Characterization of the murine orthologue of a novel human subtelomeric multigene family.	WASHC1 WASH2P	6.44e-05	5	89	2	11701968
Pubmed	BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms.	CHAF1B CHAF1A	6.44e-05	5	89	2	12771185
Pubmed	LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.	PRAMEF14 PRAMEF20 PRAMEF13	7.61e-05	32	89	3	37889087
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	PWP1 CHAF1B MDN1 SEC16A ETV6 MACF1	8.91e-05	282	89	6	23667531
Pubmed	Human subtelomeric WASH genes encode a new subclass of the WASP family.	WASHC1 WASH2P	9.65e-05	6	89	2	18159949
Pubmed	Gli2 activator function in preosteoblasts is sufficient to mediate Ihh-dependent osteoblast differentiation, whereas the repressor function of Gli2 is dispensable for endochondral ossification.	GLI2 IBSP	9.65e-05	6	89	2	20503377
Pubmed	The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells.	SETDB1 HTT	9.65e-05	6	89	2	32451438
Pubmed	Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells.	CHAF1B CSNK1D ETV6 RFC3 SCAI	9.73e-05	178	89	5	27637333
Pubmed	The HP1alpha-CAF1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin.	SETDB1 CHAF1B CHAF1A	9.99e-05	35	89	3	19498464
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF14 PRAMEF20 PRAMEF13	9.99e-05	35	89	3	19389355
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	CUL2 GPRASP1 CSNK1D PI4KB POR DKC1 HIC2 PTPRU DNAH14 WWC1	1.29e-04	925	89	10	28986522
Pubmed	A CAF-1 dependent pool of HP1 during heterochromatin duplication.	CHAF1B CHAF1A	1.35e-04	7	89	2	15306854
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	CHAF1A SQLE MRPL51 SEC16A DKC1 HIC2 HMGCR ALG12 HSPA14 HTT NSMCE1 SCAI	1.43e-04	1327	89	12	32694731
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	RPL10L CUL2 CHAF1B CSNK1D WASHC1 SEC16A DKC1 RFC3 HSPA14 SDAD1 NSMCE1 C1orf174	1.51e-04	1335	89	12	29229926
Pubmed	Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region.	WASHC1 WASH2P	1.79e-04	8	89	2	10655549
Pubmed	Dynamics of histone H3 deposition in vivo reveal a nucleosome gap-filling mechanism for H3.3 to maintain chromatin integrity.	CHAF1B CHAF1A	1.79e-04	8	89	2	22195966
Pubmed	Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.	PRAMEF14 PRAMEF20 PRAMEF13	2.27e-04	46	89	3	17287250
Pubmed	Regulation of Calvarial Osteogenesis by Concomitant De-repression of GLI3 and Activation of IHH Targets.	GLI2 IBSP	2.30e-04	9	89	2	29311969
Pubmed	Cleft lip and cleft palate in Esrp1 knockout mice is associated with alterations in epithelial-mesenchymal crosstalk.	CSNK1D GLI2 MACF1	2.42e-04	47	89	3	32253237
Pubmed	Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis.	SMYD1 TBX5	2.88e-04	10	89	2	11923873
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	PRAMEF14 PRAMEF20 PRAMEF13	2.91e-04	50	89	3	31806660
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	MDN1 PRAMEF14 PRAMEF20 PRAMEF13 MOCS1 KLHL17	3.48e-04	363	89	6	14691545
Pubmed	Complementary Gli activity mediates early patterning of the mouse visual system.	GLI2 TBX5	3.51e-04	11	89	2	16342201
Pubmed	Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly.	CHAF1B CHAF1A	3.51e-04	11	89	2	21724829
Pubmed	Gli1 protein participates in Hedgehog-mediated specification of osteoblast lineage during endochondral ossification.	GLI2 IBSP	3.51e-04	11	89	2	22493482
Pubmed	Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts.	HIC2 PBX3	3.51e-04	11	89	2	23630078
Pubmed	Analysis of hedgehog signaling in cerebellar granule cell precursors in a conditional Nsdhl allele demonstrates an essential role for cholesterol in postnatal CNS development.	GLI2 HMGCR	3.51e-04	11	89	2	25652406
Pubmed	Ermap, a gene coding for a novel erythroid specific adhesion/receptor membrane protein.	MACF1 PTPRU	3.51e-04	11	89	2	10721728
Pubmed	UBR7 acts as a histone chaperone for post-nucleosomal histone H3.	CHAF1B CHAF1A	3.51e-04	11	89	2	34786730
Pubmed	Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth.	CHAF1B CHAF1A	4.20e-04	12	89	2	17452450
Pubmed	ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.	RPL10L PRAMEF20 PRAMEF13	4.51e-04	58	89	3	31598710
Pubmed	Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells.	SQLE HMGCR	4.96e-04	13	89	2	29748249
Pubmed	The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain.	CHAF1B CHAF1A	4.96e-04	13	89	2	15882967
Pubmed	Inositol 1,4,5-trisphosphate receptors are essential for the development of the second heart field.	SMYD1 TBX5	5.78e-04	14	89	2	21382375
Pubmed	The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization.	GLI2 IBSP	5.78e-04	14	89	2	19906844
Pubmed	Systematic identification of factors for provirus silencing in embryonic stem cells.	SETDB1 CHAF1B MDN1 CHAF1A	6.58e-04	153	89	4	26365490
Pubmed	Prevention of premature fusion of calvarial suture in GLI-Kruppel family member 3 (Gli3)-deficient mice by removing one allele of Runt-related transcription factor 2 (Runx2).	GLI2 IBSP	6.65e-04	15	89	2	22547067
Pubmed	Runx2-Twist1 interaction coordinates cranial neural crest guidance of soft palate myogenesis.	HIC1 IBSP	7.59e-04	16	89	2	33482080
Pubmed	The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia.	IBSP EVC	7.59e-04	16	89	2	23026747
Pubmed	Human Asf1 regulates the flow of S phase histones during replicational stress.	CHAF1B CHAF1A	7.59e-04	16	89	2	15664198
Pubmed	Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping.	SERPINB7 ZNF407	8.59e-04	17	89	2	19690890
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF20 PRAMEF13	8.59e-04	17	89	2	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF20 PRAMEF13	8.59e-04	17	89	2	37781892
Pubmed	Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.	CHAF1B CHAF1A SCAI	9.21e-04	74	89	3	29795351
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	PWP1 SETDB1 SEC16A DKC1 RFC3 SDAD1	9.51e-04	440	89	6	34244565
Pubmed	An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.	PBX3 TBX5	9.65e-04	18	89	2	17350578
Pubmed	VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.	CUL2 RAB40C	9.65e-04	18	89	2	15601820
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF20 PRAMEF13	9.65e-04	18	89	2	39181896
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	MDN1 CSNK1D MACF1	9.95e-04	76	89	3	27542412
Pubmed	The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3.	CHAF1B CHAF1A	1.08e-03	19	89	2	20504901
Pubmed	Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.	HIC1 HIC2	1.08e-03	19	89	2	30385546
Pubmed	Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation.	CHAF1B CHAF1A SCAI	1.28e-03	83	89	3	20562864
Pubmed	Optic vesicle morphogenesis requires primary cilia.	GLI2 TBX5	1.32e-03	21	89	2	32169553
Pubmed	Twist plays an essential role in FGF and SHH signal transduction during mouse limb development.	GLI2 TBX5	1.32e-03	21	89	2	12142027
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	SETDB1 SPATA2L CSNK1D PI4KB SEC16A DKC1 TNFAIP1 WWC1 C1orf174	1.37e-03	1038	89	9	26673895
Pubmed	Diverse fates of paralogs following segmental duplication of telomeric genes.	WASHC1 WASH2P	1.45e-03	22	89	2	15233989
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ZNF532 CSNK1D GLI2 EVC MACF1 PBX3 ALG12 DNAH14 ARAP1 HTT FRMD3	1.46e-03	1489	89	11	28611215
Pubmed	HIC2 is a novel dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region.	HIC1 HIC2	1.58e-03	23	89	2	24748541
Pubmed	Physical mapping of the mouse tilted locus identifies an association between human deafness loci DFNA6/14 and vestibular system development.	EVC HTT	1.58e-03	23	89	2	11597144
Pubmed	Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity.	SEC16A ETV6	1.58e-03	23	89	2	22792062
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	MDN1 TMEM168 SQLE SEC16A MACF1 HMGCR EMC2 SCAI WDR72	1.59e-03	1061	89	9	33845483
Pubmed	Hedgehog signalling controls sinoatrial node development and atrioventricular cushion formation.	GLI2 TBX5	1.72e-03	24	89	2	34062094
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	RPL10L WAS SMYD1 PRAMEF14 PRAMEF20 PRAMEF13 TBX5	1.74e-03	674	89	7	37196079
Interaction	IMPDH1 interactions	PWP1 CSNK1D SEC16A POLL EMC2 SDAD1 DNAH14	6.02e-06	168	83	7	int:IMPDH1
Cytoband	1p36.21	PRAMEF14 PRAMEF20 PRAMEF13	2.57e-04	63	89	3	1p36.21
GeneFamily	Wiskott-Aldrich Syndrome protein family	WAS WASHC1 WASH2P	2.75e-05	16	68	3	14
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	BNC2 HIC1 ZNF532 GLI2 ZNF432 ZNF407 HIC2 ZNF615 ZNF700 ZNF763 ZNF791	6.97e-05	718	68	11	28
GeneFamily	PRAME family	PRAMEF14 PRAMEF20 PRAMEF13	9.73e-05	24	68	3	686
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	HIC1 HIC2 TNFAIP1 KLHL17	1.63e-03	134	68	4	861
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 COL6A6 GLI2 PCDH15 FRMD3 TBX5	2.21e-06	189	89	6	2a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	BNC2 COL6A6 GLI2 PCDH15 MACF1 TBX5	2.35e-06	191	89	6	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	BNC2 COL6A6 GLI2 PCDH15 MACF1 TBX5	2.42e-06	192	89	6	99ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D231\|Adult / Lineage, Cell type, age group and donor	BNC2 COL6A6 GLI2 PCDH15 MOCS1 TBX5	2.49e-06	193	89	6	ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 COL6A6 GLI2 PCDH15 FRMD3 TBX5	2.57e-06	194	89	6	89b706af2b25991fc2707eb24f49ba6ff3ae01f7
ToppCell	nucseq-Mesenchymal-Fibroblastic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	BNC2 COL6A6 GLI2 PCDH15 MACF1 TBX5	2.72e-06	196	89	6	7d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCell	nucseq-Mesenchymal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	BNC2 COL6A6 GLI2 PCDH15 MACF1 TBX5	2.89e-06	198	89	6	8f52243ca8b9ba68a75ae411506a3a6de258eb97
ToppCell	TCGA-Cervix\|World / Sample_Type by Project: Shred V9	SERPINB7 CHAF1B CASP14 CHAF1A ADGRF4	2.33e-05	170	89	5	a6cbe253bc60f5d5cb361c7e85ed9928a3155ec8
ToppCell	droplet-Limb_Muscle-nan-21m-Macroglial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPL10L SPATA2L MATN2 FRMD3 MTSS2	3.23e-05	182	89	5	a512863304fad80acaab60a8c6107eb7c9cbac99
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BNC2 EVC PBX3 DNAH14 WWC1	3.68e-05	187	89	5	c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PCDH15 EVC WWC1 FRMD3 WDR72	3.68e-05	187	89	5	3ae3b8de1a195d4d5057cf3c64fcdb5f48681ce5
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	BNC2 COL6A6 PCDH15 MACF1 TBX5	3.68e-05	187	89	5	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	Control-Fibroblasts\|Control / group, cell type (main and fine annotations)	BNC2 COL6A6 GLI2 PCDH15 TBX5	3.97e-05	190	89	5	3a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	BNC2 PCDH15 WWC1 FRMD3 WDR72	4.07e-05	191	89	5	3c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 COL6A6 GLI2 PCDH15 TBX5	4.07e-05	191	89	5	b13229bb7f3713a392271aaf5dbae3edd1b9fe5a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	BNC2 PCDH15 WWC1 FRMD3 WDR72	4.07e-05	191	89	5	1c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 COL6A6 GLI2 PCDH15 TBX5	4.17e-05	192	89	5	dcd924d6eb67d33ee9f5d3e8ab6e1d4283d6b708
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 COL6A6 GLI2 PCDH15 TBX5	4.17e-05	192	89	5	6f4ef24dab544681304b7f8a9dc073e7edaa4cf5
ToppCell	droplet-Marrow-BM-1m-Hematologic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHAF1B CHAF1A DKC1 RFC3 C1orf174	4.17e-05	192	89	5	19b8675ed8a99bd3d08ad043e4ec9f006426c22f
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 COL6A6 GLI2 PCDH15 TBX5	4.17e-05	192	89	5	3d0cb19f037f604253d7d728689aeaa94251e92b
ToppCell	droplet-Marrow-BM-1m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHAF1B CHAF1A DKC1 RFC3 C1orf174	4.17e-05	192	89	5	ced2fdbcb181ac250ff50cd4d5d886e568924203
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 COL6A6 GLI2 PCDH15 TBX5	4.17e-05	192	89	5	deeecd26972241846b4cb998edf0c7a87ff0c4df
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 COL6A6 GLI2 PCDH15 TBX5	4.27e-05	193	89	5	fb28717fadd06c3840636d25409ce80c9254bd34
ToppCell	Mesenchymal-matrix_fibroblast_1_cell\|World / Lineage, Cell type, age group and donor	BNC2 COL6A6 GLI2 PCDH15 TBX5	4.27e-05	193	89	5	acad568621ed677031797b8c2e34dafea798d681
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BNC2 GLI2 PCDH15 MACF1 TBX5	4.27e-05	193	89	5	99525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BNC2 GLI2 PCDH15 MACF1 TBX5	4.27e-05	193	89	5	b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 COL6A6 GLI2 PCDH15 TBX5	4.38e-05	194	89	5	60622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	BNC2 GLI2 PCDH15 ADCY2 TBX5	4.38e-05	194	89	5	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	LPS-antiTNF-Stromal_mesenchymal\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 COL6A6 GLI2 PCDH15 TBX5	4.38e-05	194	89	5	6e13549f697f7478b34fe71f7dd9d63c5d3db22e
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	BNC2 COL6A6 PCDH15 MACF1 ADCY2	4.38e-05	194	89	5	71d3c7448b1734de54187f902f65649f9283bd4c
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell\|Adult / Lineage, Cell type, age group and donor	BNC2 COL6A6 GLI2 PCDH15 TBX5	4.49e-05	195	89	5	61c9e09fc84d1012e472185d70ad0a06cee30d6e
ToppCell	E12.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	BNC2 HIC1 COL6A6 MATN2 ARAP1	4.49e-05	195	89	5	febe746099964b9ea9e75f2efc72c962c01f0421
ToppCell	Children_(3_yrs)-Mesenchymal\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BNC2 COL6A6 GLI2 PCDH15 TBX5	4.60e-05	196	89	5	bc94909f9b2dc08a59eef1914148b69720569c8f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MTR EVC DNAH14 WWC1 WDR72	4.60e-05	196	89	5	eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TRIM66 BNC2 HIC1 MOCS1 C1orf174	4.60e-05	196	89	5	c57a95f8b4d8d6334f269d3c16246684f4222a3e
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	COL6A6 SQLE PCDH15 HMGCR FRMD3	4.94e-05	199	89	5	8b86c69aaf60feff53aa782559cfece7342a23de
ToppCell	Control_saline-Mesenchymal_fibroblastic\|Control_saline / Treatment groups by lineage, cell group, cell type	COL6A6 PCDH15 MACF1 FRMD3 TBX5	5.06e-05	200	89	5	64ae5cf6cb4fc94cf1052abd82648f6b8e6445fe
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	BNC2 COL6A6 GLI2 PCDH15 TBX5	5.06e-05	200	89	5	311fab076f2ceb258e3970eb21e39344b894042a
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts\|Control_saline / Treatment groups by lineage, cell group, cell type	COL6A6 PCDH15 MACF1 FRMD3 TBX5	5.06e-05	200	89	5	a1fc74c1b27e104895910bc7cdce7ba33d30df7e
ToppCell	Hippocampus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Nnat_(Nnat)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RTP1 SMYD1 GLI2 MYH15	1.02e-04	121	89	4	8334a6b2ced1d6a4808458d6d4232d1b688ba28a
ToppCell	Hippocampus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Nnat_(Nnat)--\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RTP1 SMYD1 GLI2 MYH15	1.02e-04	121	89	4	4b33eeed7b70da120133b14d42c104d2461d52dc
ToppCell	Hippocampus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Nnat_(Nnat)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RTP1 SMYD1 GLI2 MYH15	1.02e-04	121	89	4	a33e4ae0b0efb702db1b646ac0486e3b6ce48457
Computational	Genes in the cancer module 189.	SETDB1 CHAF1B CHAF1A	8.03e-05	23	40	3	MODULE_189
Computational	Genes in the cancer module 127.	SETDB1 CHAF1B CHAF1A	1.17e-04	26	40	3	MODULE_127
Computational	DNA replication.	CHAF1B CHAF1A RFC3	5.31e-04	43	40	3	MODULE_158
Computational	Genes in the cancer module 125.	CHAF1B CHAF1A RFC3	5.69e-04	44	40	3	MODULE_125
Disease	Mouth Diseases	CHAF1B CHAF1A HSPA14	4.15e-06	12	80	3	C0026636
Disease	spina bifida (is_implicated_in)	GLI2 MTR	1.08e-04	6	80	2	DOID:0080016 (is_implicated_in)
Disease	neutropenia, response to metamizole, Drug-induced agranulocytosis	PTPRU RFC3	1.08e-04	6	80	2	EFO_0010971, HP_0012235, MONDO_0001475
Disease	syndromic X-linked intellectual disability Najm type (implicated_via_orthology)	RPL10L CSNK1D	1.51e-04	7	80	2	DOID:0060807 (implicated_via_orthology)
Disease	ceramide measurement	SLCO1B7 MDN1 PCDH15 RFC3 FRMD3	4.54e-04	235	80	5	EFO_0010222
Disease	Malignant neoplasm of breast	HIC1 RTP1 ZNF532 CSNK1D IBSP ZNF432 MTR MACF1 ADGRF4 HSPA14	6.40e-04	1074	80	10	C0006142
Disease	X-21441 measurement	SLCO1B7 UGT1A5	9.61e-04	17	80	2	EFO_0800814
Disease	serum albumin measurement	MACF1 ADGRF4 SERPINA10 TNFAIP1 ALG12 PDE11A WDR72	1.13e-03	592	80	7	EFO_0004535
Disease	hippocampal volume	CHAF1B SDAD1 WWC1 FRMD3 PDE11A	1.30e-03	297	80	5	EFO_0005035
Disease	airway responsiveness measurement	PCDH15 MYH15	1.93e-03	24	80	2	EFO_0006897
Disease	blood cadmium measurement	BNC2 WDR72	2.26e-03	26	80	2	EFO_0007576
Disease	thrombocytopenia (is_implicated_in)	WAS ETV6	2.44e-03	27	80	2	DOID:1588 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FMSDHVARGKAMVRS	BTNL10	101	A8MVZ5
LTRHDTMLKAMFSGR	TNFAIP1	46	Q13829
KSSFRIHRMRRMGSA	BNC2	421	Q6ZN30
FGTIMDHKIRDALRM	ADGRF4	651	Q8IZF3
RMFHDDSMKSFFRRL	CHAF1B	226	Q13112
DTMVRHFKMQIFGDR	AGO4	66	Q9HCK5
SMCITQFMKKRRHDG	CHAF1A	876	Q13111
TKMSDNLERCFHRAM	CECR2	521	Q9BXF3
KEVRRHFGAMVATMF	ALG12	116	Q9BV10
HFNRSMRALAKTKGM	POLL	511	Q9UGP5
SFTELSRIVLMRHGM	RAB40C	166	Q96S21
MGREFGNLTRMRHVI	UQCRQ	1	O14949
RTNMTYEKMSRALRH	ETV6	386	P41212
RMVGIIHRKFSSIQM	PBX3	201	P40426
NVERCRGFSAHLMKM	MDN1	4221	Q9NU22
RGFSAHLMKMLVRQR	MDN1	4226	Q9NU22
ERAVKRMRHLSTGTM	MATN2	121	O00339
NRLSKDAHRYGMRGM	POR	96	P16435
MMRAAAKDVHRLRGQ	WWC1	1066	Q8IX03
GKKFTQRGTMTRHMR	HIC1	541	Q14526
MLSRLFRMHGLFVAS	HMGCR	1	P04035
MCMRHRSIETKLRQF	MTSS2	81	Q765P7
KNHRDIFRSMLMTAC	PDE11A	801	Q9HCR9
RFKAMMASIGRLSHG	EBLN2	211	Q6P2I7
SGMERERKVSMRLHR	CSNK1D	361	P48730
MNHKKSRVMDFFRRI	MACF1	3166	O94854
GLQLRKHMTTMHRFE	GLI2	716	P10070
RKKRQHAGMFSISQM	MOCS1	361	Q9NZB8
RQEKTHMMSAVDRSF	PTPRU	796	Q92729
TGLIKTAMLFHNMRR	PCDH15	1201	Q96QU1
MLNRKTSHFLGMRVQ	CFAP119	1	A1A4V9
GRRTMKMIHFRSSSV	FRMD3	11	A2A2Y4
HTLDGAKMRASVRMT	ADCY2	481	Q08462
MCLIHIFKSGMFRRI	HTT	1781	P42858
HDAFVAMSRMRQRGL	KLHL17	76	Q6TDP4
HGRFIMSLRKAAMAE	SQLE	226	Q14534
ARMLAKRLIHGLSMS	CUL2	436	Q13617
EMQTKRDRFHMGLST	DNAH14	2251	Q0VDD8
SHRVKRLTGMRFEAM	EMC2	86	Q15006
LDALERTMGRAHMAK	EVC	366	P57679
RTMGRAHMAKVIEFL	EVC	371	P57679
HMFRQLRFESTMKRD	CASP14	41	P31944
PSMSRREFRKMHFRA	C1orf174	216	Q8IYL3
LRRVRSGVMSEKDHM	DKC1	246	O60832
RRMGVMTDVHRRFLQ	NSMCE1	6	Q8WV22
FMRSTSHTFKNGRMI	COL6A6	2241	A6NMZ7
MEAFRRRHFQTLTVM	PRAMEF13	41	Q5VWM6
HALRRTMEKYMSTCR	RFC3	146	P40938
SFKHDVRGNARAMMK	HSPA14	246	Q0VDF9
EVSMKHGTGVRCRFM	GPRASP1	651	Q5JY77
MFTQRGTMTRHMRSH	HIC2	541	Q96JB3
MVKSCGRDGFHMRVR	RPL10L	76	Q96L21
HMFLDRAQRAGSVRM	RTP1	111	P59025
LTVSLGRHMRTMKVY	TAS2R38	216	P59533
GRHMRTMKVYTRNSR	TAS2R38	221	P59533
KMGYVRRDSHRLMVT	SPATA2L	126	Q8IUW3
FRGSDDMELHRMSRM	TBX5	236	Q99593
MEAFRRRHFQTLTVM	PRAMEF14	41	Q5SWL7
IRMHFGARGMLSSVD	MYH15	261	Q9Y2K3
LGTFRLRHMKALMNE	PNMA8B	46	Q9ULN7
SFSFRGMEAIREAMH	MTR	581	Q99707
SMFHTQMRIELRALG	SMYD1	226	Q8NB12
MEAFSRRHCEALKLM	PRAMEF20	41	Q5VT98
LGMACAFSMKNLHRR	IBSP	11	P21815
KNVMMSARTLIHLFR	SDAD1	426	Q9NVU7
KALAIGFHSMIMRSL	SLCO1B7	521	G3V0H7
SSTIRNLKERFHMSM	PI4KB	766	Q9UBF8
MTARRRVNRKMGFHV	SETDB1	611	Q15047
TKHGMMKFREDRSLL	ARAP1	1276	Q96P48
SLVHSRDMKMGVLFC	PWP1	421	Q13610
MCGKAFSRKSRLMDH	ZNF615	236	Q8N8J6
THMRTHGMAFIKSKR	ZNF532	1281	Q9HCE3
KTFIFHSSIRRHMVM	ZNF700	201	Q9H0M5
GKAFMRLSSLTRHMR	ZNF791	106	Q3KP31
IERMMSRIFRHSSVG	TMPRSS11F	91	Q6ZWK6
SKMDSRTHARVMTRF	SEC16A	1651	O15027
CIRKRKMVGSRMFAD	MRPL51	91	Q4U2R6
MSGKTKARRAAMFFR	SUN3	1	Q8TAQ9
GHLMSDLFNKLVMRR	WASH2P	406	Q6VEQ5
GHLMSDLFNKLVMRR	WASHC1	406	A8K0Z3
GSSFRMESIHNKMRG	WDR72	926	Q3MJ13
LVGALMHVMQKRSRA	WAS	466	P42768
FETEHLLMKFSRRMA	UGT1A5	101	P35504
LTRFIFCSATMRMHK	SCAI	541	Q8N9R8
FCSATMRMHKIFRET	SCAI	546	Q8N9R8
ASGGRLYISRMMHKS	SERPINB7	311	O75635
DRIMASKGMRHFCLI	TMEM168	341	Q9H0V1
LLRKISMRHDGNMVF	SERPINA10	86	Q9UK55
GFTMKSRMIEHQRTH	ZNF432	381	O94892
RGTSETQRMYMKHLR	ZNF407	451	Q9C0G0
FISHSGIRRRMVMHS	ZNF763	181	Q0D2J5
HMENERAKRMSFRLA	TRIM66	1196	O15016
IRKFHSMASRAEMPQ	TRIM50	241	Q86XT4
FSLGRDRMTSTMHKM	UHRF1BP1	1051	Q6BDS2
TVSIAAKRRFHMEAM	MYMK	21	A6NI61