Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	bicarbonate transmembrane transporter activity	SLC26A3 SLC4A5 SLC4A3 SLC4A11	1.37e-05	32	92	4	GO:0015106
GeneOntologyMolecularFunction	solute:inorganic anion antiporter activity	SLC26A3 SLC4A5 SLC4A3 SLC4A11	1.37e-05	32	92	4	GO:0005452
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	ANO9 SLC26A3 CLCN7 CLCA2 SLC4A5 SLC4A3 SLC4A11	1.42e-05	171	92	7	GO:0015103
GeneOntologyMolecularFunction	antiporter activity	SLC26A3 CLCN7 SLC4A5 SLC4A3 SLC1A5 SLC4A11	4.28e-05	138	92	6	GO:0015297
GeneOntologyMolecularFunction	DNA-dependent protein kinase activity	PRKDC ATM	6.28e-05	3	92	2	GO:0004677
GeneOntologyMolecularFunction	histone H2AXS139 kinase activity	PRKDC ATM	6.28e-05	3	92	2	GO:0035979
GeneOntologyMolecularFunction	monoatomic anion transmembrane transporter activity	ANO9 SLC26A3 CLCN7 CLCA2 SLC4A5 SLC4A3	7.07e-05	151	92	6	GO:0008509
GeneOntologyMolecularFunction	cyclosporin A binding	PPIAL4E PPIAL4D PPIAL4F	1.79e-04	24	92	3	GO:0016018
GeneOntologyMolecularFunction	histone H2AX kinase activity	PRKDC ATM	2.08e-04	5	92	2	GO:0141003
GeneOntologyMolecularFunction	chloride transmembrane transporter activity	ANO9 SLC26A3 CLCN7 CLCA2 SLC4A3	2.82e-04	125	92	5	GO:0015108
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	CACNA1F ANO9 SLC26A3 CLCN7 CLCA2 UCP1 TRPC4 SLC4A5 SLC4A3 RYR2 SLC4A11	7.18e-04	758	92	11	GO:0015318
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	CACNA1F ANO9 SLC26A3 CLCN7 CLCA2 UCP1 TRPC4 SLC4A5 SLC4A3 RYR2 SLC4A11	1.04e-03	793	92	11	GO:0015075
GeneOntologyMolecularFunction	chloride:bicarbonate antiporter activity	SLC26A3 SLC4A3	1.58e-03	13	92	2	GO:0140900
GeneOntologyMolecularFunction	bicarbonate:monoatomic anion antiporter activity	SLC26A3 SLC4A3	1.58e-03	13	92	2	GO:0140829
GeneOntologyMolecularFunction	peptidyl-prolyl cis-trans isomerase activity	PPIAL4E PPIAL4D PPIAL4F	1.59e-03	50	92	3	GO:0003755
GeneOntologyMolecularFunction	cis-trans isomerase activity	PPIAL4E PPIAL4D PPIAL4F	1.88e-03	53	92	3	GO:0016859
GeneOntologyBiologicalProcess	inorganic anion transport	ANO9 SLC26A3 CLCN7 CLCA2 SLC4A5 SLC4A3 SLC4A11	1.73e-05	180	93	7	GO:0015698
GeneOntologyBiologicalProcess	intra-Golgi vesicle-mediated transport	RAB6D RAB6B RAB6A RAB6C	1.82e-05	35	93	4	GO:0006891
GeneOntologyBiologicalProcess	monoatomic anion transport	ANO9 SLC26A3 CLCN7 CLCA2 SLC4A5 SLC4A3 SLC4A11	1.92e-05	183	93	7	GO:0006820
GeneOntologyBiologicalProcess	bicarbonate transport	SLC26A3 SLC4A5 SLC4A3 SLC4A11	2.54e-05	38	93	4	GO:0015701
GeneOntologyBiologicalProcess	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	AGO2 PABPC3 PABPC1	3.12e-05	14	93	3	GO:0060213
GeneOntologyBiologicalProcess	inorganic anion transmembrane transport	ANO9 SLC26A3 CLCN7 CLCA2 SLC4A3 SLC4A11	3.22e-05	134	93	6	GO:0098661
GeneOntologyBiologicalProcess	regulation of nuclear-transcribed mRNA poly(A) tail shortening	AGO2 PABPC3 PABPC1	4.76e-05	16	93	3	GO:0060211
GeneOntologyBiologicalProcess	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	AGO2 PABPC3 PABPC1	4.76e-05	16	93	3	GO:1900153
GeneOntologyBiologicalProcess	monoatomic anion transmembrane transport	ANO9 SLC26A3 CLCN7 CLCA2 SLC4A5 SLC4A3	6.77e-05	153	93	6	GO:0098656
GeneOntologyBiologicalProcess	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	RAB6D RAB6B RAB6A RAB6C	9.58e-05	53	93	4	GO:0006890
GeneOntologyBiologicalProcess	chloride transmembrane transport	ANO9 SLC26A3 CLCN7 CLCA2 SLC4A3	1.53e-04	112	93	5	GO:1902476
GeneOntologyBiologicalProcess	protein localization to Golgi membrane	RAB6B RAB6A	1.99e-04	5	93	2	GO:1903292
GeneOntologyBiologicalProcess	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	AGO2 PABPC3 PABPC1	2.40e-04	27	93	3	GO:1900151
GeneOntologyBiologicalProcess	plasminogen activation	TMPRSS9 PLAU SERPINF2	2.68e-04	28	93	3	GO:0031639
GeneOntologyBiologicalProcess	chloride transport	ANO9 SLC26A3 CLCN7 CLCA2 SLC4A3	2.86e-04	128	93	5	GO:0006821
Domain	PTrfase/Anion_transptr	SLC4A5 SLC4A3 SLC4A11	1.35e-05	10	92	3	IPR016152
Domain	HCO3_transpt_euk	SLC4A5 SLC4A3 SLC4A11	1.35e-05	10	92	3	IPR003020
Domain	HCO3_cotransp	SLC4A5 SLC4A3 SLC4A11	1.35e-05	10	92	3	PF00955
Domain	HCO3_transpt_C	SLC4A5 SLC4A3 SLC4A11	1.35e-05	10	92	3	IPR011531
Domain	PolyA	PABPC3 PABPC1	2.38e-04	5	92	2	SM00517
Domain	-	PABPC3 PABPC1	2.38e-04	5	92	2	1.10.1900.10
Domain	PABP	PABPC3 PABPC1	2.38e-04	5	92	2	PF00658
Domain	PABP_1234	PABPC3 PABPC1	2.38e-04	5	92	2	IPR006515
Domain	FATC	PRKDC ATM	2.38e-04	5	92	2	PF02260
Domain	PABC	PABPC3 PABPC1	2.38e-04	5	92	2	PS51309
Domain	PABP_HYD	PABPC3 PABPC1	2.38e-04	5	92	2	IPR002004
Domain	FAT	PRKDC ATM	3.55e-04	6	92	2	PS51189
Domain	FATC	PRKDC ATM	3.55e-04	6	92	2	PS51190
Domain	FAT	PRKDC ATM	3.55e-04	6	92	2	PF02259
Domain	PIK-rel_kinase_FAT	PRKDC ATM	3.55e-04	6	92	2	IPR003151
Domain	FATC_dom	PRKDC ATM	3.55e-04	6	92	2	IPR003152
Domain	PIK_FAT	PRKDC ATM	3.55e-04	6	92	2	IPR014009
Domain	FATC	PRKDC ATM	3.55e-04	6	92	2	SM01343
Domain	ANION_EXCHANGER_2	SLC4A5 SLC4A3	4.96e-04	7	92	2	PS00220
Domain	ANION_EXCHANGER_1	SLC4A5 SLC4A3	4.96e-04	7	92	2	PS00219
Domain	VWFA	MDN1 CLCA2 ITGA10 CPNE7	7.19e-04	82	92	4	PS50234
Domain	VWA	MDN1 CLCA2 ITGA10 CPNE7	7.87e-04	84	92	4	SM00327
Domain	-	SLC4A5 SLC4A3	8.45e-04	9	92	2	3.40.1100.10
Domain	Band3_cytoplasmic_dom	SLC4A5 SLC4A3	8.45e-04	9	92	2	IPR013769
Domain	Band_3_cyto	SLC4A5 SLC4A3	8.45e-04	9	92	2	PF07565
Domain	VWF_A	MDN1 CLCA2 ITGA10 CPNE7	1.45e-03	99	92	4	IPR002035
Domain	GrpE_coiled_coil	TRIM32 DNAH8	1.53e-03	12	92	2	IPR013805
Domain	ATPase_dyneun-rel_AAA	MDN1 DNAH8	2.10e-03	14	92	2	IPR011704
Domain	AAA_5	MDN1 DNAH8	2.10e-03	14	92	2	PF07728
Domain	PI3/4_kinase_CS	PRKDC ATM	2.42e-03	15	92	2	IPR018936
Domain	-	PRKDC ATM	2.75e-03	16	92	2	1.10.1070.11
Domain	PI3Kc	PRKDC ATM	2.75e-03	16	92	2	SM00146
Domain	PI3_PI4_kinase	PRKDC ATM	3.49e-03	18	92	2	PF00454
Domain	PI3_4_KINASE_1	PRKDC ATM	3.49e-03	18	92	2	PS00915
Domain	PI3_4_KINASE_2	PRKDC ATM	3.49e-03	18	92	2	PS00916
Domain	PI3/4_kinase_cat_dom	PRKDC ATM	3.49e-03	18	92	2	IPR000403
Domain	PI3_4_KINASE_3	PRKDC ATM	3.49e-03	18	92	2	PS50290
Domain	Cyclophilin-type_PPIase_CS	PPIAL4D PPIAL4F	3.89e-03	19	92	2	IPR020892
Domain	Cyclophilin-type_PPIase	PPIAL4D PPIAL4F	4.74e-03	21	92	2	IPR024936
Domain	Pro_isomerase	PPIAL4D PPIAL4F	5.20e-03	22	92	2	PF00160
Domain	Cyclophilin-type_PPIase_dom	PPIAL4D PPIAL4F	5.20e-03	22	92	2	IPR002130
Domain	EPHD	KMT2B KDM4A	5.20e-03	22	92	2	PS51805
Domain	Cyclophilin-like_dom	PPIAL4D PPIAL4F	5.20e-03	22	92	2	IPR029000
Pathway	REACTOME_DNA_DOUBLE_STRAND_BREAK_REPAIR	POLE RNF8 KDM4A PRKDC ATM KPNA2	5.09e-05	146	64	6	MM15292
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	ANO9 CLCN7 CLCA2 TRPC4 RYR2	8.47e-05	99	64	5	MM14910
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	ANO9 CLCN7 CLCA2 TRPC4 RYR2	1.17e-04	106	64	5	M27200
Pathway	REACTOME_DNA_DOUBLE_STRAND_BREAK_REPAIR	POLE RNF8 KDM4A PRKDC ATM KPNA2	1.18e-04	170	64	6	M27582
Pathway	REACTOME_DNA_DOUBLE_STRAND_BREAK_RESPONSE	RNF8 KDM4A ATM KPNA2	1.27e-04	57	64	4	MM15298
Pathway	REACTOME_SENSING_OF_DNA_DOUBLE_STRAND_BREAKS	ATM KPNA2	3.01e-04	6	64	2	M27585
Pathway	REACTOME_SENSING_OF_DNA_DOUBLE_STRAND_BREAKS	ATM KPNA2	3.01e-04	6	64	2	MM15295
Pathway	REACTOME_DNA_DOUBLE_STRAND_BREAK_RESPONSE	RNF8 KDM4A ATM KPNA2	4.28e-04	78	64	4	M27589
Pathway	WP_FTO_OBESITY_VARIANT_MECHANISM	UCP1 ARID5B	5.58e-04	8	64	2	M39356
Pathway	WP_NIPBL_ROLE_IN_DNA_DAMAGE_CORNELIA_DE_LANGE_SYNDROME	RNF8 ATM	5.58e-04	8	64	2	M42528
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FASN MDN1 KMT2B CLCN7 POLE SIPA1L3 APBB3 PRKDC ZC3H7B PLEKHG5 PREX1 AHDC1 SLC1A5 ARAP1 BAHCC1	2.75e-07	1105	94	15	35748872
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ZSWIM8 TRIM32 SIPA1L3 ARID5B ETS2 NAV3 APBB3 MLLT3 FBXO11 KDM4A PRKDC ATM YME1L1 PREX1 SLC4A3 RAB6A	3.35e-07	1285	94	16	35914814
Pubmed	Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.	AGO2 PABPC3 PABPC1	6.81e-06	14	94	3	19716330
Pubmed	Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis.	PRKDC ATM	7.23e-06	2	94	2	11231155
Pubmed	Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation.	PRKDC ATM	7.23e-06	2	94	2	10464290
Pubmed	Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM.	PRKDC ATM	7.23e-06	2	94	2	27939942
Pubmed	The DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) Are stimulated by bulky adduct-containing DNA.	PRKDC ATM	7.23e-06	2	94	2	21487018
Pubmed	Activation of DNA Damage Response Pathways during Lytic Replication of KSHV.	PRKDC ATM	7.23e-06	2	94	2	26057167
Pubmed	Rab6-Mediated Polarized Transport of Synaptic Vesicle Precursors Is Essential for the Establishment of Neuronal Polarity and Brain Formation.	RAB6B RAB6A	7.23e-06	2	94	2	38830762
Pubmed	Detailed technical analysis of urine RNA-based tumor diagnostics reveals ETS2/urokinase plasminogen activator to be a novel marker for bladder cancer.	ETS2 PLAU	7.23e-06	2	94	2	17921261
Pubmed	Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells.	RAB6A RAB6C	7.23e-06	2	94	2	11054569
Pubmed	The promoter of the Poly(A) binding protein 2 (Pabp2) retroposon is derived from the 5'-untranslated region of the Pabp1 progenitor gene.	PABPC3 PABPC1	7.23e-06	2	94	2	10534404
Pubmed	DNA double-strand break formation upon UV-induced replication stress activates ATM and DNA-PKcs kinases.	PRKDC ATM	7.23e-06	2	94	2	19071136
Pubmed	Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells.	PRKDC ATM	7.23e-06	2	94	2	12065055
Pubmed	Global analysis of AGO2-bound RNAs reveals that miRNAs induce cleavage of target RNAs with limited complementarity.	AGO2 PRKDC	7.23e-06	2	94	2	29031931
Pubmed	Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.	PRKDC ATM	7.23e-06	2	94	2	17189255
Pubmed	AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation.	PRKDC ATM	7.23e-06	2	94	2	22972376
Pubmed	G(2)-M phase-correlative bystander effects are co-mediated by DNA-PKcs and ATM after carbon ion irradiation.	PRKDC ATM	7.23e-06	2	94	2	26774662
Pubmed	Nucleotide sequence of a mouse testis poly(A) binding protein cDNA.	PABPC3 PABPC1	7.23e-06	2	94	2	1630930
Pubmed	Developmental expression of poly(A) binding protein mRNAs during spermatogenesis in the mouse.	PABPC3 PABPC1	7.23e-06	2	94	2	7893484
Pubmed	Characterization of two cytoplasmic poly(A)-binding proteins, PABPC1 and PABPC2, in mouse spermatogenic cells.	PABPC3 PABPC1	7.23e-06	2	94	2	19020299
Pubmed	DNA-PKcs and ATM modulate mitochondrial ADP-ATP exchange as an oxidative stress checkpoint mechanism.	PRKDC ATM	7.23e-06	2	94	2	36727301
Pubmed	Functional compensation for the loss of testis-specific poly(A)-binding protein, PABPC2, during mouse spermatogenesis.	PABPC3 PABPC1	7.23e-06	2	94	2	26971890
Pubmed	Polyserase-1/TMPRSS9 induces pro-tumor effects in pancreatic cancer cells by activation of pro-uPA.	TMPRSS9 PLAU	7.23e-06	2	94	2	24756697
Pubmed	Deciphering the role of distinct DNA-PK phosphorylations at collapsed replication forks.	PRKDC ATM	7.23e-06	2	94	2	32674014
Pubmed	Levels of free PABP are limited by newly polyadenylated mRNA in early Spisula embryogenesis.	PABPC3 PABPC1	7.23e-06	2	94	2	10954604
Pubmed	Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions.	PRKDC ATM	7.23e-06	2	94	2	21245310
Pubmed	The molecular causes of low ATM protein expression in breast carcinoma; promoter methylation and levels of the catalytic subunit of DNA-dependent protein kinase.	PRKDC ATM	7.23e-06	2	94	2	17593081
Pubmed	The mouse gene encoding the testis-specific isoform of Poly(A) binding protein (Pabp2) is an expressed retroposon: intimations that gene expression in spermatogenic cells facilitates the creation of new genes.	PABPC3 PABPC1	7.23e-06	2	94	2	9732454
Pubmed	Targeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiation.	PRKDC ATM	7.23e-06	2	94	2	20617180
Pubmed	PABPC1 interacts with AGO2 and is responsible for the microRNA mediated gene silencing in high grade hepatocellular carcinoma.	AGO2 PABPC1	7.23e-06	2	94	2	26188282
Pubmed	DNA protein kinase-dependent G2 checkpoint revealed following knockdown of ataxia-telangiectasia mutated in human mammary epithelial cells.	PRKDC ATM	7.23e-06	2	94	2	18172300
Pubmed	Identification of potential protein interactors of Lrrk2.	AGO2 MDN1 PRKDC	8.50e-06	15	94	3	17400507
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	ZNF536 SALL1 MDN1 POLE ARID5B CSMD2 YME1L1 PREX1 RAB6A RYR2	9.12e-06	638	94	10	31182584
Pubmed	Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131.	KMT2B KDM4A RAB6B RAB6A BAHCC1	1.27e-05	110	94	5	26841866
Pubmed	Embryonic Poly(A)-Binding Protein Is Required During Early Stages of Mouse Oocyte Development for Chromatin Organization, Transcriptional Silencing, and Meiotic Competence.	PABPC3 PABPC1	2.16e-05	3	94	2	26134869
Pubmed	Human testis expresses a specific poly(A)-binding protein.	PABPC3 PABPC1	2.16e-05	3	94	2	11328870
Pubmed	Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.	PRKDC ATM	2.16e-05	3	94	2	9766667
Pubmed	Identification and characterization of FUS/TLS as a new target of ATM.	PRKDC ATM	2.16e-05	3	94	2	18620545
Pubmed	Superovulation alters embryonic poly(A)-binding protein (Epab) and poly(A)-binding protein, cytoplasmic 1 (Pabpc1) gene expression in mouse oocytes and early embryos.	PABPC3 PABPC1	2.16e-05	3	94	2	25034140
Pubmed	Severe hypoxia increases expression of ATM and DNA-PKcs and it increases their activities through Src and AMPK signaling pathways.	PRKDC ATM	2.16e-05	3	94	2	30224064
Pubmed	DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks.	PRKDC ATM	2.16e-05	3	94	2	18644470
Pubmed	Tagging single nucleotide polymorphisms in phosphoinositide-3-kinase-related protein kinase genes involved in DNA damage "checkpoints" and lung cancer susceptibility.	PRKDC ATM	2.16e-05	3	94	2	18451257
Pubmed	Rab6 family proteins interact with the dynein light chain protein DYNLRB1.	RAB6B RAB6A	2.16e-05	3	94	2	18044744
Pubmed	Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination.	PRKDC ATM	2.16e-05	3	94	2	23836881
Pubmed	DNA Damage Signaling Is Required for Replication of Human Bocavirus 1 DNA in Dividing HEK293 Cells.	PRKDC ATM	2.16e-05	3	94	2	27733644
Pubmed	Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study.	UBXN2B PREX1	2.16e-05	3	94	2	23496005
Pubmed	Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase.	RNF8 ATM	2.16e-05	3	94	2	18006705
Pubmed	RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells.	RNF8 ATM	2.16e-05	3	94	2	32502756
Pubmed	SIRT1 Functions as a Negative Regulator of Eukaryotic Poly(A)RNA Transport.	PABPC3 PABPC1	2.16e-05	3	94	2	28756945
Pubmed	The poly(A)-binding protein genes, EPAB, PABPC1, and PABPC3 are differentially expressed in infertile men with non-obstructive azoospermia.	PABPC3 PABPC1	2.16e-05	3	94	2	26843391
Pubmed	Dynamic change of histone H2AX phosphorylation independent of ATM and DNA-PK in mouse skin in situ.	PRKDC ATM	2.16e-05	3	94	2	17923115
Pubmed	DNA damage, metabolism and aging in pro-inflammatory T cells: Rheumatoid arthritis as a model system.	PRKDC ATM	2.16e-05	3	94	2	29101015
Pubmed	DNA-PKcs and ATM epistatically suppress DNA end resection and hyperactivation of ATR-dependent G2-checkpoint in S-phase irradiated cells.	PRKDC ATM	2.16e-05	3	94	2	31601897
Pubmed	Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.	MLLT3 PRKDC	2.16e-05	3	94	2	18538732
Pubmed	Nuclear relocalisation of cytoplasmic poly(A)-binding proteins PABP1 and PABP4 in response to UV irradiation reveals mRNA-dependent export of metazoan PABPs.	PABPC3 PABPC1	2.16e-05	3	94	2	21940797
Pubmed	Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy.	PRKDC ATM	2.16e-05	3	94	2	25205036
Pubmed	ATM phosphorylates histone H2AX in response to DNA double-strand breaks.	PRKDC ATM	2.16e-05	3	94	2	11571274
Pubmed	Radiation-dose-dependent functional synergisms between ATM, ATR and DNA-PKcs in checkpoint control and resection in G2-phase.	PRKDC ATM	2.16e-05	3	94	2	31164689
Pubmed	The mouse Y-box protein, MSY2, is associated with a kinase on non-polysomal mouse testicular mRNAs.	PABPC3 PABPC1	2.16e-05	3	94	2	10076007
Pubmed	Tissue-specific DNA-PK-dependent H2AX phosphorylation and gamma-H2AX elimination after X-irradiation in vivo.	PRKDC ATM	2.16e-05	3	94	2	18755145
Pubmed	Perturbations in ataxia telangiectasia mutant signaling pathways after drug-induced acute liver failure and their reversal during rescue of animals by cell therapy.	PRKDC ATM	2.16e-05	3	94	2	21224054
Pubmed	Epab and Pabpc1 are differentially expressed during male germ cell development.	PABPC3 PABPC1	2.16e-05	3	94	2	22814100
Pubmed	Phosphorylation at S2053 in Murine (S2056 in Human) DNA-PKcs Is Dispensable for Lymphocyte Development and Class Switch Recombination.	PRKDC ATM	2.16e-05	3	94	2	31101667
Pubmed	The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest.	PRKDC ATM	2.16e-05	3	94	2	10677503
Pubmed	A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6.	RAB6B RAB6A	2.16e-05	3	94	2	23737971
Pubmed	De novo variants in the PABP domain of PABPC1 lead to developmental delay.	PABPC3 PABPC1	2.16e-05	3	94	2	35511136
Pubmed	The involvement of c-Myc in the DNA double-strand break repair via regulating radiation-induced phosphorylation of ATM and DNA-PKcs activity.	PRKDC ATM	2.16e-05	3	94	2	26049366
Pubmed	Inefficient double-strand break repair in murine rod photoreceptors with inverted heterochromatin organization.	PRKDC ATM	2.16e-05	3	94	2	24794298
Pubmed	The SAGA Deubiquitination Module Promotes DNA Repair and Class Switch Recombination through ATM and DNAPK-Mediated γH2AX Formation.	PRKDC ATM	2.16e-05	3	94	2	27160905
Pubmed	Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma.	CRISPLD2 PREX1	2.16e-05	3	94	2	34624316
Pubmed	[Potentials of DNA-PKcs, Ku80, and ATM in enhancing radiosensitivity of cervical carcinoma cells].	PRKDC ATM	2.16e-05	3	94	2	17626748
Pubmed	Ionizing radiation-induced XRCC4 phosphorylation is mediated through ATM in addition to DNA-PK.	PRKDC ATM	2.16e-05	3	94	2	25391321
Pubmed	Epab is dispensable for mouse spermatogenesis and male fertility.	PABPC3 PABPC1	2.16e-05	3	94	2	24599567
Pubmed	Differential 3' Processing of Specific Transcripts Expands Regulatory and Protein Diversity Across Neuronal Cell Types.	PABPC3 PABPC1	2.16e-05	3	94	2	29578408
Pubmed	Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells.	PRKDC ATM	2.16e-05	3	94	2	19444312
Pubmed	Domain-functional analyses of PIWIL1 and PABPC1 indicate their synergistic roles in protein translation via 3'-UTRs of meiotic mRNAs.	PABPC3 PABPC1	2.16e-05	3	94	2	29701755
Pubmed	Isolation and characterization of alpha2-plasmin inhibitor from human plasma. A novel proteinase inhibitor which inhibits activator-induced clot lysis.	PLAU SERPINF2	2.16e-05	3	94	2	134998
Pubmed	Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors.	PRKDC ATM	2.16e-05	3	94	2	15389585
Pubmed	Cohen syndrome-associated protein COH1 physically and functionally interacts with the small GTPase RAB6 at the Golgi complex and directs neurite outgrowth.	RAB6B RAB6A	2.16e-05	3	94	2	25492866
Pubmed	Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation.	PRKDC ATM	2.16e-05	3	94	2	21245316
Pubmed	Translation repression via modulation of the cytoplasmic poly(A)-binding protein in the inflammatory response.	PABPC3 PABPC1	2.16e-05	3	94	2	28635594
Pubmed	Nuclear localization of cytoplasmic poly(A)-binding protein upon rotavirus infection involves the interaction of NSP3 with eIF4G and RoXaN.	ZC3H7B PABPC1	2.16e-05	3	94	2	18799579
Pubmed	The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM.	PRKDC ATM	2.16e-05	3	94	2	16603769
Pubmed	Epab and Pabpc1 are differentially expressed in the postnatal mouse ovaries.	PABPC3 PABPC1	2.16e-05	3	94	2	25370180
Pubmed	Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage.	PRKDC ATM	2.16e-05	3	94	2	21824916
Pubmed	Cytoplasmic poly(A)-binding protein 1 (PABPC1) interacts with the RNA-binding protein hnRNPLL and thereby regulates immunoglobulin secretion in plasma cells.	PABPC3 PABPC1	2.16e-05	3	94	2	28611064
Pubmed	A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway.	PABPC3 PABPC1	2.16e-05	3	94	2	37665675
Pubmed	Synergy between Prkdc and Trp53 regulates stem cell proliferation and GI-ARS after irradiation.	PRKDC ATM	2.16e-05	3	94	2	28686579
Pubmed	ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaks.	PRKDC ATM	2.16e-05	3	94	2	32890395
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	FASN AGO2 MDN1 POLE PRKDC PLOD1 PABPC1 PREX1 SLC1A5 KPNA2	2.73e-05	725	94	10	27025967
Pubmed	Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.	FASN AGO2 CLCN7 LNPEP ARPIN PRKDC SLC1A5 RAB6A	3.06e-05	449	94	8	31732153
Pubmed	Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis.	RAB6B RAB6A RAB6C	3.26e-05	23	94	3	20360680
Pubmed	Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B.	PABPC3 PABPC1	4.32e-05	4	94	2	16804161
Pubmed	Wortmannin potentiates integrase-mediated killing of lymphocytes and reduces the efficiency of stable transduction by retroviruses.	PRKDC ATM	4.32e-05	4	94	2	11158303
Pubmed	SPO11 is required for sex-body formation, and Spo11 heterozygosity rescues the prophase arrest of Atm-/- spermatocytes.	PRKDC ATM	4.32e-05	4	94	2	15998665
Pubmed	Inhibition of DNA-dependent protein kinase reduced palmitate and oleate-induced lipid accumulation in HepG2 cells.	FASN PRKDC	4.32e-05	4	94	2	23184344
Pubmed	Mouse cdc21 only 0.5 kb upstream from dna-pkcs in a head-to-head organization: an implication of co-evolution of ATM family members and cell cycle regulating genes.	PRKDC ATM	4.32e-05	4	94	2	9716665
Pubmed	Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP.	PABPC3 PABPC1	4.32e-05	4	94	2	18490513
Pubmed	Stress granules inhibit apoptosis by reducing reactive oxygen species production.	PABPC3 PABPC1	4.32e-05	4	94	2	23230274
Cytoband	19q13.13	WDR87 SIPA1L3	4.28e-04	15	94	2	19q13.13
Cytoband	1q21.2	PPIAL4E PPIAL4D PPIAL4F	4.30e-04	71	94	3	1q21.2
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	FASN KNDC1 ITGA10 CSMD2 C2CD4C SLC4A3 CDH13 RYR2 CPNE7	4.34e-10	200	94	9	5c7263c862093ad9dbc81d06b16b6f74e8a6b634
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	ZNF536 NAV3 HPSE2 CSMD2 DNAH8 CDH13 RYR2	4.77e-08	159	94	7	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	COVID-19-Fibroblasts-Alveolar_FB\|COVID-19 / group, cell type (main and fine annotations)	CRISPLD2 DPP6 TRPC4 NAV3 KAZN CDH13 RYR2	1.92e-07	195	94	7	603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26\|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.	FASN ITGA10 CSMD2 C2CD4C CDH13 RYR2 CPNE7	2.28e-07	200	94	7	61d7dd0a78942b069c3f5e75044368dc00e6e8e6
ToppCell	PCW_07-8.5-Neuronal-Neuronal_SCP-neuro_SCP_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TBX22 ZNF536 TRPC4 CSMD2 PREX1 CDH13	2.37e-06	181	94	6	fad7ba168f541ac9d04edebc206f191e48bb7e99
ToppCell	PCW_07-8.5-Neuronal-Neuronal_SCP\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TBX22 ZNF536 TRPC4 CSMD2 PREX1 CDH13	2.69e-06	185	94	6	56c7a0dbf141728ac76b8c90af197719942ca67c
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	CRISPLD2 DPP6 TRPC4 NAV3 CDH13 RYR2	2.86e-06	187	94	6	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	COVID-19-Fibroblasts-Other_FB\|COVID-19 / group, cell type (main and fine annotations)	CRISPLD2 ZNF536 NAV3 HPSE2 KAZN RYR2	3.43e-06	193	94	6	e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ANO9 SNCAIP LNPEP ARID5B MLLT3 ATM	3.86e-06	197	94	6	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARID5B ETS2 HPSE2 PLAU KAZN CDH13	3.97e-06	198	94	6	09be07ebfc3e49c3858e9b74605b69cf4fc28b56
ToppCell	COVID-19-kidney-PEC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PARD6B DPP6 ZNF536 KAZN SLC4A11	2.87e-05	168	94	5	a086c306be430adf0632ba53e98cd8014d2de330
ToppCell	10x5'-blood-Myeloid_Dendritic-pDC\|blood / Manually curated celltypes from each tissue	SERPINF2 PCSK4 SLC4A3 CDH13 BAHCC1	3.04e-05	170	94	5	59cb1262ff319349d42b11afbec2a9035b7b79f2
ToppCell	Adult-Mesenchymal-airway_smooth_muscle_cell\|Adult / Lineage, Cell type, age group and donor	ZNF536 TRPC4 HPSE2 CDH13 RYR2	3.30e-05	173	94	5	a5331721bd9f9a66530dd4ffe28cb3a5a8cad8fc
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CRISPLD2 HPSE2 DNAH8 CDH13 RYR2	3.49e-05	175	94	5	316f2ea930437bf1243b1c0f45e6bd864112c6f2
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CRISPLD2 HPSE2 DNAH8 CDH13 RYR2	3.49e-05	175	94	5	a9f08e1e4c2997dcdd3e5d92daac480da19100b8
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|390C / Donor, Lineage, Cell class and subclass (all cells)	HPSE2 CSMD2 SLC4A5 SLC4A3 RYR2	3.58e-05	176	94	5	852d3da0907fe87c0ef23d75a63ce07619cf0c54
ToppCell	facs-Lung-Endomucin-24m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNCAIP NRAP CLCA2 NAV3 CPNE7	3.58e-05	176	94	5	057d2759fdc67176c25802b57a78064d8cc93205
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNCAIP NRAP CLCA2 NAV3 CPNE7	3.58e-05	176	94	5	b81e5d23b31cefc8d374ef403e21acc390c14a80
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	HPSE2 CSMD2 SLC4A5 SLC4A3 RYR2	3.58e-05	176	94	5	d2df1e435996c51213e88270af9f928e9e09a6f5
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CRISPLD2 ZNF536 ITGA10 HPSE2 CDH13	3.68e-05	177	94	5	b59967219f7d874805768e247c0eb2bc4d4420c8
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PARD6B CACNA1F DPP6 RASSF9 CDH13	4.10e-05	181	94	5	b45b11428d13950369347e051d4d517efb2bd4fd
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	NRAP LRRC2 POPDC2 CDH13 RYR2	4.10e-05	181	94	5	719eb532453ab7cd7893726885bc75d74a10b21e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CRISPLD2 ZNF536 NAV3 ADAMTS18 SLC4A11	4.10e-05	181	94	5	5f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CRISPLD2 ZNF536 NAV3 ADAMTS18 SLC4A11	4.10e-05	181	94	5	c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCell	facs-Lung-24m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SNCAIP CLCA2 NAV3 PLOD1 CPNE7	4.20e-05	182	94	5	2cc434e46985c66fc36de05344a67aa96d90abc9
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRISPLD2 ETS2 HPSE2 POPDC2 SLC4A3	4.20e-05	182	94	5	ffe500d78a89dc6b4d05bab1664e7f30c94fb8d9
ToppCell	facs-Lung-24m-Endothelial-lymphatic_endothelial\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SNCAIP CLCA2 NAV3 PLOD1 CPNE7	4.20e-05	182	94	5	0cde2775bdaaa2172499925bd59b0ac2d545eb27
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CRISPLD2 ZNF536 ETS2 HPSE2 RYR2	4.20e-05	182	94	5	ed6ae0fd8653f213fe29906a6a4e0729a62e1b75
ToppCell	facs-Lung-24m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SNCAIP CLCA2 NAV3 PLOD1 CPNE7	4.20e-05	182	94	5	3e7457b2a70b45735fb75d6617b7f34cef28758e
ToppCell	PCW_07-8.5-Neuronal-Neuronal_SCP-neuro_proliferating_SCP2_(1)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TBX22 ZNF536 TRPC4 CSMD2 CDH13	4.32e-05	183	94	5	e0854864d377e158a4793088d1cb6b3dbf2c805d
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRISPLD2 ETS2 HPSE2 POPDC2 SLC4A3	4.43e-05	184	94	5	94748f63947db79a6b4540e3090a63689fdd9452
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRISPLD2 ETS2 HPSE2 POPDC2 SLC4A3	4.43e-05	184	94	5	819b277ecced7b415e363c7e7ddbc6f3b2d296de
ToppCell	COVID-19-Heart-CM_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	NRAP LRRC2 POPDC2 SLC4A3 RYR2	4.43e-05	184	94	5	e737f0f14c49b07bbb04a165083ac32210bc5690
ToppCell	COVID-19-Heart-CM_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	NRAP LRRC2 POPDC2 CDH13 RYR2	4.54e-05	185	94	5	549eeb521c3985bff396ea0f202db21822efa51f
ToppCell	PCW_05-06-Neuronal-Neuronal_SCP-neuro_proliferating_SCP1_(1)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	TMPRSS9 ZNF536 CSMD2 PREX1 CDH13	4.54e-05	185	94	5	a8946379fc066903fe8f4bc9cbf693b7b424a0cd
ToppCell	PCW_07-8.5-Neuronal-Neuronal_SCP-neuro_proliferating_SCP1_(1)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TBX22 ZNF536 TRPC4 CSMD2 CDH13	4.66e-05	186	94	5	3113c85d0ac5fc46532c19b1bb71f34b985e1276
ToppCell	PCW_07-8.5-Neuronal\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TBX22 ZNF536 TRPC4 CSMD2 CDH13	4.66e-05	186	94	5	7a4bb42f3f6a27b463e48eafc587d9ab3386f2fb
ToppCell	facs-Aorta-Heart-3m-Endothelial-nan\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNCAIP UCP1 ARID5B PLOD1 CDH13	4.78e-05	187	94	5	df0279b7e94e26f5541b0e2a0ce56befa96ec8ca
ToppCell	facs-Heart-Unknown-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRAP LRRC2 POPDC2 SLC4A3 RYR2	4.78e-05	187	94	5	0ffb988e0da2c7205c3515eca8e9851739bff5c5
ToppCell	facs-Heart-Unknown\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRAP LRRC2 POPDC2 SLC4A3 RYR2	4.78e-05	187	94	5	362e56426a568423a81e8a30e3ecf99b76135843
ToppCell	Control-Fibroblasts-Other_FB\|Control / group, cell type (main and fine annotations)	CRISPLD2 ZNF536 NAV3 HPSE2 RYR2	4.78e-05	187	94	5	bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCell	facs-Heart-Unknown-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRAP LRRC2 POPDC2 SLC4A3 RYR2	4.78e-05	187	94	5	c004567767b89f3d89f5c7b28d952f3445957e1e
ToppCell	-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	CRISPLD2 TRPC4 ARID5B NAV3 CDH13	4.91e-05	188	94	5	038f48e8daaeb72716e975d22a6b004a90654960
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRAP LRRC2 POPDC2 SLC4A3 RYR2	4.91e-05	188	94	5	4db566f3f708e66730aa9e16f4d73d91dc534177
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CRISPLD2 SALL1 ITGA10 PLAU CSMD2	4.91e-05	188	94	5	997dcfc4f08738ab398d8abc15e4fd2fc6619862
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRAP LRRC2 POPDC2 SLC4A3 RYR2	4.91e-05	188	94	5	6704b92991ad8c0a910e9f36cd33d00bd26dcb8f
ToppCell	human_hepatoblastoma-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ZNF462 DPP6 SIPA1L3 ADAMTS18 MLLT3	4.91e-05	188	94	5	b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCell	COVID-19-Heart\|COVID-19 / Disease (COVID-19 only), tissue and cell type	NRAP LRRC2 POPDC2 CDH13 RYR2	5.16e-05	190	94	5	918ad5037881212008f9f69d5df5da91fd01422c
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CRISPLD2 CLCA2 ITGA10 HPSE2 CDH13	5.16e-05	190	94	5	7df63e5e0dd395676f4fc18cad0d8b2428390943
ToppCell	Control-Fibroblasts\|Control / group, cell type (main and fine annotations)	CRISPLD2 NAV3 HPSE2 CDH13 RYR2	5.16e-05	190	94	5	3a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CRISPLD2 CLCA2 ITGA10 HPSE2 CDH13	5.16e-05	190	94	5	140aca04c044cd7a93f81ff1631b00b5216d2cb1
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CRISPLD2 TRPC4 HPSE2 CDH13 RYR2	5.29e-05	191	94	5	04c4d454b57e29a8d1dcdeb4678ce71bdc29b77b
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CRISPLD2 CLCA2 ITGA10 HPSE2 CDH13	5.42e-05	192	94	5	26d9207e72bbef5e0046de511e2c9ff752b726f3
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CRISPLD2 NAV3 HPSE2 CDH13 RYR2	5.42e-05	192	94	5	99ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CRISPLD2 CLCA2 ITGA10 HPSE2 CDH13	5.56e-05	193	94	5	7fc3ab7261c88c1df71744bf5b17e8e46c4300e0
ToppCell	facs-Skin-Telogen-3m-Epithelial\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LNPEP ARID5B ETS2 RAB6A CDH13	5.69e-05	194	94	5	4d7fc4d0a55abb3b645116d13a983bbedc55f70c
ToppCell	Control-Fibroblasts-Intermediate_pathological_FB\|Control / group, cell type (main and fine annotations)	CRISPLD2 NAV3 HPSE2 CSMD2 RYR2	5.69e-05	194	94	5	03a269f75a481ea54aea8e6444605db8d6df493d
ToppCell	facs-Skin-Telogen-3m\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LNPEP ARID5B ETS2 RAB6A CDH13	5.69e-05	194	94	5	ba10fc5929649bb994c3f1d2ce6ca3167fa9b11b
ToppCell	facs-Skin-Telogen\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LNPEP ARID5B ETS2 RAB6A CDH13	5.69e-05	194	94	5	bafecab8d48fc94ffd93f0d054b5f32c04b6b3f6
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SNCAIP ETS2 NAV3 PREX1 CDH13	5.98e-05	196	94	5	22767bcf0095d9eb0cbed7cdc74e4d32d9357e1b
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARID5B ETS2 PLAU KAZN CDH13	5.98e-05	196	94	5	85507488f83d8f71b3ee2ad5e5aa0b6ad6193873
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SNCAIP ETS2 NAV3 PREX1 CDH13	5.98e-05	196	94	5	adee900dcd16dbaba15c58bdcace09ba20214950
ToppCell	COVID-19-Heart-Mito_CM\|COVID-19 / Disease (COVID-19 only), tissue and cell type	NRAP LRRC2 POPDC2 SLC4A3 RYR2	6.12e-05	197	94	5	44e49943d62bfe622b40ad0460093d31540544df
ToppCell	COVID-19-Fibroblasts-Intermediate_pathological_FB\|COVID-19 / group, cell type (main and fine annotations)	CRISPLD2 NAV3 KAZN CSMD2 RYR2	6.12e-05	197	94	5	f1c8936986123a3151140c374fcd62d6705c530b
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CRISPLD2 SALL1 ETS2 PLAU CDH13	6.12e-05	197	94	5	1da8ba5bbab232add6e43ad78b15c2339d0c2bc3
ToppCell	COVID-19-Fibroblasts\|COVID-19 / group, cell type (main and fine annotations)	CRISPLD2 NAV3 KAZN CSMD2 RYR2	6.12e-05	197	94	5	fb847f2277609c31fffcdf49517243ce0684facf
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SNCAIP ETS2 NAV3 PREX1 CDH13	6.27e-05	198	94	5	07701c73137947ed4a27e225975329235bbb8734
ToppCell	Adult-Mesenchymal\|Adult / Lineage, Cell type, age group and donor	CRISPLD2 TRPC4 NAV3 CDH13 RYR2	6.27e-05	198	94	5	26e55b409db2a1637c95fae7c54b0abea1ef550c
ToppCell	COVID-19-lung-Fibroblast\|lung / Disease (COVID-19 only), tissue and cell type	CRISPLD2 NAV3 KAZN CDH13 RYR2	6.27e-05	198	94	5	df3de77216f5c5d6141ec44d01c56b942f611838
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal-Dividing_Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CLCA2 ETS2 RASSF9 GINS1 KPNA2	6.27e-05	198	94	5	f088badb90c6c2d916195f5649eda102119c9ac6
ToppCell	Mesenchymal\|World / Lineage, Cell type, age group and donor	CRISPLD2 NAV3 HPSE2 KAZN RYR2	6.42e-05	199	94	5	4bac110c2b3609f6ee5d0e3275da0824a6240270
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ZNF462 CRISPLD2 DPP6 CSMD2 CDH13	6.42e-05	199	94	5	333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCell	PSB-critical-LOC-Epithelial-Basal\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CLCA2 PHLDA3 ARID5B LRRC2 SLC1A5	6.42e-05	199	94	5	2add64c3e4cb6384ec381f34c3f1f77e13e3f27c
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ZNF462 CRISPLD2 DPP6 CSMD2 CDH13	6.42e-05	199	94	5	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ZNF462 CRISPLD2 DPP6 CSMD2 CDH13	6.42e-05	199	94	5	e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCell	Parenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CRISPLD2 TRPC4 HPSE2 CDH13 RYR2	6.42e-05	199	94	5	b1753474152b82a0b811b9878c890a359e14919a
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF536 ARID5B ETS2 HPSE2 KAZN	6.42e-05	199	94	5	bdedcc7c8f3be0996200c882dda82fb2658655c0
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CRISPLD2 TRPC4 NAV3 CDH13 RYR2	6.58e-05	200	94	5	e8462395fee0a532d1e7ec7f1795f28c42af6541
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CRISPLD2 TRPC4 HPSE2 CDH13 RYR2	6.58e-05	200	94	5	a66449b22b39dd6987fc2c3ed160d24564234ced
ToppCell	Parenchymal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CRISPLD2 TRPC4 NAV3 CDH13 RYR2	6.58e-05	200	94	5	cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CRISPLD2 TRPC4 NAV3 CDH13 RYR2	6.58e-05	200	94	5	311fab076f2ceb258e3970eb21e39344b894042a
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CRISPLD2 TRPC4 NAV3 CDH13 RYR2	6.58e-05	200	94	5	34f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCell	droplet-Tongue-nan-24m-Epithelial-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACP7 FBXO11 PLAU KAZN	7.00e-05	104	94	4	a4ae3cae44aac8b6e0d14896f9acab44f0cc97c4
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRISPLD2 PARD6B SLC1A5 CPNE7	1.66e-04	130	94	4	e5acaa9aaa22b10d11410e2c01647b31354c21ed
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp4_Mab21l1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ZNF536 SALL1 SLC1A5 CPNE7	1.97e-04	136	94	4	9cf076597e6fd9390850fda259daa13022f15893
ToppCell	Control-B_memory-6\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	RASSF9 DNAH8 PREX1 SLC4A11	1.97e-04	136	94	4	94f23bef50c0beb54ed39b1a4b340f7aec4e75cd
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp6_Pltp\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ZNF536 SALL1 TRPC4 CPNE7	2.14e-04	139	94	4	9e9f29f92dbe65b26cc78b3a1c00778c6a701f5b
ToppCell	LA-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	ANO9 NRAP POPDC2 RYR2	2.14e-04	139	94	4	9e2a84d5ed7232b70eadbba754d9ca13f2d50fe9
ToppCell	367C-Myeloid-Macrophage-SPP1+_Macrophage_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	ZNF462 ROPN1L ARID5B AHDC1	2.45e-04	144	94	4	38ff324366ad5be626e3657c1e33277fc36ddd4c
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-7\|TCGA-Endometrium / Sample_Type by Project: Shred V9	CRISPLD2 DPP6 TRPC4 CDH13	2.52e-04	145	94	4	ffbdadea0185e5d3b85f2868d5ec82b50cf2e2a1
ToppCell	COVID-19-kidney-Technical/muscle_(PCT)\|kidney / Disease (COVID-19 only), tissue and cell type	HPSE2 CSMD2 CDH13 RYR2	2.59e-04	146	94	4	c55f1bdb6ac43b4118cb27ea7c879527e1afcbab
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Cortical_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1F SLC26A3 THAP10 SLC4A11	2.65e-04	147	94	4	f703cb0330304799d16e457215269c7732c9d5d5
ToppCell	LA-15._Ventricular_Cardiomyocyte_III\|LA / Chamber and Cluster_Paper	ANO9 NRAP POPDC2 RYR2	2.65e-04	147	94	4	8970eb6b82589f39439c61a57d999661ec8342de
ToppCell	COVID-19-kidney-Technical/muscle\|kidney / Disease (COVID-19 only), tissue and cell type	HPSE2 DNAH8 CDH13 RYR2	2.72e-04	148	94	4	0dbd87078f54ee1c2f8ec64e8bac9dfddb9c181e
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Fam159b\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ZNF536 SNCAIP SALL1 CPNE7	2.72e-04	148	94	4	9205b26e0d042b342cc643cda0f4f3f8bb392d00
ToppCell	severe_influenza-Treg\|World / disease group, cell group and cell class (v2)	CACNA1F PHLDA3 ARID5B LRRC2	2.80e-04	149	94	4	2a3a00cdf604c8f3f3863df0ddb06938549bf86d
ToppCell	Children_(3_yrs)-Mesenchymal-myofibroblast_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CRISPLD2 ZNF536 ITGA10 HPSE2	3.02e-04	152	94	4	621e9b33cd3bb1c7b7d0633069f286b203e3d9c0
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CRISPLD2 ZNF536 ITGA10 HPSE2	3.09e-04	153	94	4	1524557514668f515ac1bbe847611f564b265b42
ToppCell	IIH-Treg\|IIH / Condition, Cell_class and T cell subcluster	ARID5B HPSE2 LRRC2 DNAH8	3.09e-04	153	94	4	17704e18833812fcf2a2727b1e3f8a9984ba5b59
ToppCell	TCGA-Thryoid-Solid_Tissue_Normal-Thryoid_normal_tissue-Thryoid_normal_tissue-3\|TCGA-Thryoid / Sample_Type by Project: Shred V9	TBX22 DPP6 RASSF9 RYR2	3.17e-04	154	94	4	4e9203c220a44c70cd7979796a0b461991422257
Drug	Albendazole [54965-21-8]; Down 200; 15uM; HL60; HG-U133A	FASN MDN1 KMT2B POLE PHLDA3 ATM ZC3H7B SLC1A5	1.12e-06	194	91	8	1547_DN
Drug	pioglitazone HCl; Down 200; 10uM; PC3; HT_HG-U133A	SIPA1L3 NAV3 ARPIN MLLT3 PLAU ZC3H7B CPNE7	1.29e-05	194	91	7	6893_DN
Drug	NS-398; Down 200; 10uM; PC3; HT_HG-U133A	VPS13D SIPA1L3 NAV3 MLLT3 ZNF79 ZC3H7B CPNE7	1.34e-05	195	91	7	6892_DN
Drug	3-Acetylcoumarin [3949-36-8]; Down 200; 21.2uM; MCF7; HT_HG-U133A	PARD6B PCDHA9 CLCA2 ITGA10 ZNF79 RAB6B RYR2	1.38e-05	196	91	7	5624_DN
Drug	clozapine; Up 200; 10uM; MCF7; HT_HG-U133A	SIPA1L3 ITGA10 ZNF79 AHDC1 RYR2 CPNE7 BAHCC1	1.43e-05	197	91	7	6988_UP
Drug	Niacin [59-67-6]; Down 200; 32.4uM; MCF7; HT_HG-U133A	ZSWIM8 DNAJC13 SIPA1L3 ETS2 MLLT3 ZC3H7B ARAP1	1.43e-05	197	91	7	5301_DN
Drug	Aceclofenac [89796-99-6]; Up 200; 11.2uM; MCF7; HT_HG-U133A	CLCN7 TRIM32 SIPA1L3 FBXO11 ZNF79 AHDC1 RYR2	1.53e-05	199	91	7	7029_UP
Drug	dehydroretinyl acetate	SLC26A3 SLC1A5	1.58e-05	2	91	2	CID006441422
Drug	4,4'-diisothiocyanostilbene-2,2'-disulfonic acid	SLC26A3 CLCN7 CLCA2 YME1L1 SLC4A5 SLC4A3 SLC4A11	1.91e-05	206	91	7	CID000040600
Drug	Aphidicolin	POLE PRKDC ATM	4.03e-05	17	91	3	ctd:D016590
Drug	Trichostatin A, Streptomyces sp.; Down 200; 1uM; HL60; HT_HG-U133A	ZNF536 NAV3 PLAU KAZN ARAP1 BAHCC1	8.07e-05	178	91	6	6193_DN
Drug	troglitazone; Down 200; 10uM; PC3; HT_HG-U133A	SIPA1L3 NAV3 MLLT3 PLAU ZC3H7B BAHCC1	1.09e-04	188	91	6	4456_DN
Drug	ikarugamycin; Up 200; 2uM; MCF7; HT_HG-U133A_EA	NUDT18 CRISPLD2 TRIM32 FBXO11 ZNF79 ARAP1	1.09e-04	188	91	6	974_UP
Drug	troglitazone; Down 200; 10uM; PC3; HT_HG-U133A	VPS13D ARID5B NAV3 PLAU ZNF79 ARAP1	1.12e-04	189	91	6	1232_DN
Drug	Muramic acid, N-acetyl [10597-89-4]; Down 200; 13.6uM; MCF7; HT_HG-U133A	PARD6B VPS13D CLCN7 SIPA1L3 ATM ARAP1	1.12e-04	189	91	6	3262_DN
Drug	15d-PGJ2; Down 200; 10uM; MCF7; HT_HG-U133A	PARD6B ZSWIM8 VPS13D KMT2B FBXO11 ZC3H7B	1.22e-04	192	91	6	6990_DN
Drug	5155877; Up 200; 10uM; PC3; HT_HG-U133A	CLCN7 SIPA1L3 PHLDA3 MLLT3 KAZN ATM	1.22e-04	192	91	6	6544_UP
Drug	Ciclopirox ethanolamine [41621-49-2]; Down 200; 15uM; PC3; HT_HG-U133A	CRISPLD2 ETS2 NAV3 PLAU ZNF79 KAZN	1.26e-04	193	91	6	6677_DN
Drug	5155877; Down 200; 10uM; MCF7; HT_HG-U133A	ARID5B ARPIN FBXO11 ZNF79 ZC3H7B ARAP1	1.26e-04	193	91	6	6574_DN
Drug	Mexiletine hydrochloride [5370-01-4]; Down 200; 18.6uM; PC3; HT_HG-U133A	FBXO11 ZNF79 KAZN ZC3H7B AHDC1 ARAP1	1.26e-04	193	91	6	4338_DN
Drug	Iopromide [73334-07-3]; Up 200; 5uM; MCF7; HT_HG-U133A	NUDT18 PCDHA9 ITGA10 ATM ZC3H7B RAB6B	1.29e-04	194	91	6	3481_UP
Drug	Pridinol methanesulfonate salt [6856-31-1]; Down 200; 10.2uM; MCF7; HT_HG-U133A	KMT2B LNPEP MLLT3 KDM4A KAZN ZC3H7B	1.29e-04	194	91	6	7214_DN
Drug	Bacampicillin hydrochloride [37661-08-8]; Down 200; 8uM; MCF7; HT_HG-U133A	PARD6B PCDHA9 SIPA1L3 ITGA10 ATM ZC3H7B	1.29e-04	194	91	6	3273_DN
Drug	Serotonin hydrochloride [153-98-0]; Down 200; 18.8uM; MCF7; HT_HG-U133A	NUDT18 VPS13D CLCN7 PLAU ATM BAHCC1	1.29e-04	194	91	6	5268_DN
Drug	Benzthiazide [91-33-8]; Down 200; 9.2uM; MCF7; HT_HG-U133A	PARD6B PCDHA9 ETS2 ITGA10 ZNF79 BAHCC1	1.29e-04	194	91	6	4952_DN
Drug	Mefenamic acid [61-68-7]; Down 200; 16.6uM; MCF7; HT_HG-U133A	ZSWIM8 VPS13D KMT2B MLLT3 ATM AHDC1	1.29e-04	194	91	6	1699_DN
Drug	Spiramycin [8025-81-8]; Down 200; 4.8uM; MCF7; HT_HG-U133A	VPS13D ITGA10 ARPIN PLAU ATM ARAP1	1.29e-04	194	91	6	3938_DN
Drug	Antazoline hydrochloride [2508-72-7]; Down 200; 13.2uM; MCF7; HT_HG-U133A	VPS13D ETS2 ITGA10 ZNF79 ARAP1 BAHCC1	1.33e-04	195	91	6	3173_DN
Drug	Gabapentin [60142-96-3]; Up 200; 23.4uM; MCF7; HT_HG-U133A	PARD6B CLCN7 ARPIN KAZN ATM ARAP1	1.33e-04	195	91	6	3472_UP
Drug	Myricetin [529-44-2]; Down 200; 12.6uM; MCF7; HT_HG-U133A	SNCAIP CLCN7 CLCA2 PLAU ZC3H7B ARAP1	1.33e-04	195	91	6	4170_DN
Drug	Rescinnamin [24815-24-5]; Down 200; 6.4uM; MCF7; HT_HG-U133A	PARD6B ETS2 ARPIN PLAU RYR2 ARAP1	1.33e-04	195	91	6	4386_DN
Drug	Isopropamide iodide [71-81-8]; Up 200; 8.4uM; MCF7; HT_HG-U133A	PARD6B VPS13D PCDHA9 CLCN7 CPNE7 BAHCC1	1.37e-04	196	91	6	6781_UP
Drug	Ethosuximide [77-67-8]; Down 200; 28.4uM; MCF7; HT_HG-U133A	CLCN7 ITGA10 PLAU KAZN ZC3H7B BAHCC1	1.37e-04	196	91	6	2280_DN
Drug	Phenylpropanolamine hydrochloride [154-41-6]; Down 200; 21.4uM; MCF7; HT_HG-U133A	LNPEP SIPA1L3 ARPIN ZNF79 ZC3H7B BAHCC1	1.37e-04	196	91	6	3217_DN
Drug	Orphenadrine hydrochloride [341-69-5]; Down 200; 13uM; MCF7; HT_HG-U133A	PARD6B LNPEP PLAU ATM ZC3H7B BAHCC1	1.37e-04	196	91	6	4359_DN
Drug	Diphemanil methylsulfate [62-97-5]; Down 200; 10.2uM; PC3; HT_HG-U133A	VPS13D KAZN SLC4A3 ARAP1 CPNE7 BAHCC1	1.37e-04	196	91	6	4591_DN
Drug	chlorpromazine hydrochloride; Down 200; 1uM; MCF7; HT_HG-U133A	PARD6B VPS13D PCDHA9 CLCN7 ITGA10 ZC3H7B	1.37e-04	196	91	6	5577_DN
Drug	Diphenylpyraline hydrochloride [132-18-3]; Up 200; 12.6uM; MCF7; HT_HG-U133A	CLCN7 CLCA2 LRRC2 RAB6B ARAP1 CPNE7	1.37e-04	196	91	6	6061_UP
Drug	Ampicillin trihydrate [7177-48-2]; Up 200; 10uM; MCF7; HT_HG-U133A	NUDT18 ARPIN ZNF79 ATM ARAP1 ALPG	1.41e-04	197	91	6	1530_UP
Drug	Pindolol [13523-86-9]; Up 200; 16.2uM; MCF7; HT_HG-U133A	PARD6B ZNF536 VPS13D CLCA2 HPSE2 ARAP1	1.41e-04	197	91	6	2238_UP
Drug	Fenbufen [36330-85-5]; Down 200; 15.8uM; MCF7; HT_HG-U133A	PARD6B SIPA1L3 FBXO11 ZC3H7B RYR2 CPNE7	1.41e-04	197	91	6	3618_DN
Drug	aspirin, USP; Up 200; 100uM; MCF7; HT_HG-U133A	VPS13D ETS2 FBXO11 ARAP1 CPNE7 BAHCC1	1.41e-04	197	91	6	1629_UP
Drug	Papaverine hydrochloride [61-25-6]; Down 200; 10.6uM; MCF7; HT_HG-U133A	PARD6B PCDHA9 SIPA1L3 ZNF79 ATM ZC3H7B	1.41e-04	197	91	6	2747_DN
Drug	Isocarboxazid [59-63-2]; Up 200; 17.2uM; MCF7; HT_HG-U133A	PLAU ZNF79 KAZN ZC3H7B RAB6B RYR2	1.45e-04	198	91	6	3424_UP
Drug	Azathioprine [446-86-6]; Down 200; 14.4uM; MCF7; HT_HG-U133A	CLCA2 SIPA1L3 ETS2 FBXO11 PLAU KAZN	1.45e-04	198	91	6	5262_DN
Drug	Fursultiamine Hydrochloride [2105-43-3]; Down 200; 9.2uM; MCF7; HT_HG-U133A	PARD6B VPS13D ZNF79 ZC3H7B AHDC1 RYR2	1.45e-04	198	91	6	7349_DN
Drug	Betazole hydrochloride; Down 200; 27uM; MCF7; HT_HG-U133A	ZSWIM8 PCDHA9 CLCN7 ETS2 AHDC1 ARAP1	1.45e-04	198	91	6	5445_DN
Drug	Verapamyl hydrochloride [152-11-4]; Up 200; 8.2uM; MCF7; HT_HG-U133A	NUDT18 CLCN7 FBXO11 PLAU ATM RAB6B	1.45e-04	198	91	6	5387_UP
Drug	Rauwolscine hydrochloride [6211-32-1]; Down 200; 10.2uM; MCF7; HT_HG-U133A	ZSWIM8 VPS13D PCDHA9 CLCN7 FBXO11 ATM	1.49e-04	199	91	6	2778_DN
Drug	Lysergol [602-85-7]; Up 200; 15.8uM; HL60; HT_HG-U133A	CRISPLD2 VPS13D SIPA1L3 ZNF79 KAZN BAHCC1	1.49e-04	199	91	6	1325_UP
Drug	Xylometazoline hydrochloride [1218-35-5]; Down 200; 14.2uM; MCF7; HT_HG-U133A	PARD6B FBXO11 PLAU ZNF79 ATM RYR2	1.49e-04	199	91	6	2270_DN
Drug	Terazosin hydrochloride [63590-64-7]; Down 200; 9.4uM; HL60; HT_HG-U133A	CLCN7 FBXO11 ZNF79 KAZN ZC3H7B CPNE7	1.49e-04	199	91	6	2530_DN
Drug	beta- Belladonnine dichloroethylate [191355-47-2]; Down 200; 6uM; MCF7; HT_HG-U133A	PARD6B VPS13D SIPA1L3 ETS2 KAZN ARAP1	1.49e-04	199	91	6	2819_DN
Drug	Iproniazide phosphate [305-33-9]; Down 200; 14.4uM; MCF7; HT_HG-U133A	VPS13D CLCA2 ITGA10 PLAU ATM AHDC1	1.49e-04	199	91	6	5458_DN
Drug	Alfuzosin hydrochloride [81403-68-1]; Down 200; 9.4uM; MCF7; HT_HG-U133A	NUDT18 ZSWIM8 CLCN7 ITGA10 ZNF79 BAHCC1	1.49e-04	199	91	6	3203_DN
Drug	Citalopram hydrobromide [59729-32-7]; Down 200; 1uM; PC3; HT_HG-U133A	KMT2B SIPA1L3 NAV3 KDM4A RYR2 CPNE7	1.49e-04	199	91	6	4555_DN
Drug	Imipramine hydrochloride [113-52-0]; Up 200; 12.6uM; MCF7; HT_HG-U133A	VPS13D FBXO11 ATM RYR2 ARAP1 CPNE7	1.53e-04	200	91	6	1685_UP
Drug	Maprotiline hydrochloride [10347-81-6]; Down 200; 12.8uM; PC3; HT_HG-U133A	VPS13D ATM ZC3H7B RYR2 CPNE7 BAHCC1	1.53e-04	200	91	6	6676_DN
Disease	retinal degeneration (implicated_via_orthology)	RAB6D RAB6B RAB6A RAB6C	3.38e-06	33	92	4	DOID:8466 (implicated_via_orthology)
Disease	anemia (implicated_via_orthology)	SLC4A5 SLC4A3 SLC4A11	1.30e-05	15	92	3	DOID:2355 (implicated_via_orthology)
Disease	lung non-small cell carcinoma (is_implicated_in)	POLE FBXO11 PLAU ATM CDH13	7.64e-05	139	92	5	DOID:3908 (is_implicated_in)
Disease	diastolic blood pressure, systolic blood pressure	CRISPLD2 CLCA2 TRPC4 ARID5B THAP10 FBXO11 CDH13 RYR2 CPNE7	2.47e-04	670	92	9	EFO_0006335, EFO_0006336
Disease	Ventricular Fibrillation	PLAU SLC4A3	2.66e-04	8	92	2	C0042510
Disease	breast cancer (is_marker_for)	KMT2B LNPEP PLAU KDM4A CDH13	2.90e-04	185	92	5	DOID:1612 (is_marker_for)
Disease	Cardiomyopathy, Dilated	FASN UCP1 ATM	4.58e-04	48	92	3	C0007193
Disease	Cardiomyopathy, Familial Idiopathic	FASN UCP1 ATM	5.17e-04	50	92	3	C1449563
Disease	age-related hearing impairment	TMPRSS9 ZNF536 CCM2 AGO2 ARID5B SLC4A11	5.40e-04	324	92	6	EFO_0005782
Disease	endometrial carcinoma (is_implicated_in)	POLE CDH13	6.22e-04	12	92	2	DOID:2871 (is_implicated_in)
Disease	PARKINSON DISEASE, LATE-ONSET	DNAJC13 SNCAIP	6.22e-04	12	92	2	C3160718
Disease	risk-taking behaviour	DPP6 ZNF536 RP1L1 ARID5B FBXO11 CDH13 RYR2 BAHCC1 KPNA2	6.39e-04	764	92	9	EFO_0008579
Disease	urate measurement, bone density	SALL1 ARID5B ETS2 KAZN PRKDC DNAH8 CDH13 SLC4A11	7.11e-04	619	92	8	EFO_0003923, EFO_0004531
Disease	aortic measurement	ARID5B ADAMTS18 PREX1 CDH13 RYR2	1.15e-03	251	92	5	EFO_0020865
Disease	Benign neoplasm of stomach	POLE ATM	1.27e-03	17	92	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	POLE ATM	1.27e-03	17	92	2	C0496905
Disease	Carcinoma in situ of stomach	POLE ATM	1.27e-03	17	92	2	C0154060
Disease	susceptibility to mononucleosis measurement	MDN1 DNAH8 RYR2	1.32e-03	69	92	3	EFO_0008403
Disease	prostate cancer (is_marker_for)	KMT2B PLAU KDM4A PREX1	1.46e-03	156	92	4	DOID:10283 (is_marker_for)
Disease	Stomach Carcinoma	POLE ATM	1.94e-03	21	92	2	C0699791
Disease	testosterone measurement	DPP6 ZNF536 FASN UBXN2B ARID5B KNDC1 FBXO11 KAZN SERPINF2 ARAP1 KPNA2	2.05e-03	1275	92	11	EFO_0004908
Disease	response to selective serotonin reuptake inhibitor	KAZN CSMD2 PREX1	2.17e-03	82	92	3	EFO_0005658
Disease	serum gamma-glutamyl transferase measurement	PARD6B SALL1 UBXN2B SIPA1L3 RP1L1 MLLT3 RYR2 BAHCC1 KPNA2	2.21e-03	914	92	9	EFO_0004532
Disease	attempted suicide	NAV3 KAZN DNAH8 PREX1	2.37e-03	178	92	4	EFO_0004321
Disease	lung squamous cell carcinoma (is_implicated_in)	POLE ATM	2.54e-03	24	92	2	DOID:3907 (is_implicated_in)
Disease	breast carcinoma (is_implicated_in)	FBXO11 CDH13	2.75e-03	25	92	2	DOID:3459 (is_implicated_in)
Disease	nevus count, cutaneous melanoma	NUDT18 ANO9 ATM	2.92e-03	91	92	3	EFO_0000389, EFO_0004632
Disease	blood rubidium measurement	PREX1 CDH13	2.98e-03	26	92	2	EFO_0021529

Protein segments in the cluster

Peptide	Gene	Start	Entry
SRFLGGKARRIIGDF	SLC4A3	916	P48751
GSLQKGPKDFDRFLV	BAHCC1	206	Q9P281
RKLGPEGELLIRFFN	SLC1A5	246	Q15758
LIKFSAKGLAPARGF	CSMD2	1706	Q7Z408
FLQSLKGFPRGDKLF	SERPINF2	456	P08697
NPTEDFRRKLLKAGG	MLLT3	126	P42568
LYGDSRKFLLLGLRP	CCM2	341	Q9BSQ5
KTRGDGPFLDSLAKL	ARPIN	161	Q7Z6K5
PGRGRRKKVDLFEAS	AHDC1	1231	Q5TGY3
VFEARFPLHKGEGRL	ANO9	146	A1A5B4
DRPERSKFRLTGKGV	CDH13	166	P55290
FFDGLGPASVRKLAL	C2CD4C	376	Q8TF44
EKGFQGKLITFPERR	ADAMTS18	1081	Q8TE60
IFGDRKPVFDGRKNL	AGO2	86	Q9UKV8
EATFGEKRFLLGKPS	RASSF9	61	O75901
PRLFQLDSKGRGDLL	PCDHA9	61	Q9Y5H5
DFGNPLRKFKLVFLG	RAB6A	6	P20340
DFGNPLRKFKLVFLG	RAB6B	6	Q9NRW1
DFGNPLRKFKLVFLG	RAB6C	6	Q9H0N0
DFGNPLRKFKLVFLG	RAB6D	6	Q53S08
RLKDLFGKFGPALSV	PABPC1	206	P11940
EFRRFSLERSKPGKF	PARD6B	26	Q9BYG5
GTFVPFVDGGILRRK	ACP7	76	Q6ZNF0
KPGGFDVKALRAFRV	CACNA1F	196	O60840
KGREDRAPLLKTFSF	OAZ2	141	O95190
DFGKKELSPALRNRF	MDN1	1526	Q9NU22
RLPLGKIGRGFSSKD	KAZN	721	Q674X7
VRFVFLARPTGGILK	NUDT18	116	Q6ZVK8
LRDGGYKLRLDALPF	NRAP	1036	Q86VF7
EASLPRVFKLFRALG	CLCN7	751	P51798
RLARKFGFVNLGPIF	PCSK4	51	Q6UW60
PTFRRLFGAKAGGKS	NAV3	1246	Q8IVL0
LGTPRDGKAFRIFAV	CRISPLD2	481	Q9H0B8
TFSGFKKEQRRLGIP	ETS2	86	P15036
GEKFRARSLKFPGLI	DNAH8	2956	Q96JB1
GKRLERLAKGFFPGS	KDM4A	216	O75164
PKDRGKRSSAFVFEL	LRRC2	91	Q9BYS8
FELAGLGKVPLKRAF	LNPEP	736	Q9UIQ6
EGINFKRKFLTGLEP	KMT2B	1711	Q9UMN6
LRFGFERLKEPGEKT	POLE	46	Q07864
TRDGKPLGRISIKLF	PPIAL4F	11	P0DN26
RGLSPAFLRFGGKRT	HPSE2	106	Q8WWQ2
RLKDLFGKFGPALSV	PABPC3	206	Q9H361
TRDGKPLGRISIKLF	PPIAL4E	11	A0A075B759
FASGPRELLKKFRQA	PLOD1	106	Q02809
IRAGLIPKFVSFLGR	KPNA2	116	P52292
TRDGKPLGRISIKLF	PPIAL4D	11	F5H284
PGSFTLLLRNRKGFV	MOGAT2	196	Q3SYC2
SSIFGLAPGKARDRK	ALPG	391	P10696
FKAEFRLAGGVNLPK	ATM	2686	Q13315
KRGVFSFLDAFRLKP	APBB3	466	O95704
PILRKNRIFDGFAAG	FBXO11	766	Q86XK2
KRFSALGFGARIPPK	CPNE7	431	Q9UBL6
GFLAFTQLPKFRERL	DNAJC13	441	O75165
PRKTKGSGFFVFSRL	IGHE	376	P01854
LFLSGAPRFRHRGKV	ITGA10	446	O75578
PRKAFLDRKNGLSSF	KNDC1	341	Q76NI1
KDGRKFFFIRAIPQG	DPP6	441	P42658
GLPRRSGKLKDLSRF	FASN	46	P49327
LGILFPFRDRGKFKN	SALL1	986	Q9NSC2
RFLLGGRHGEFKFLP	RYR2	801	Q92736
FGKGIREDIARRFPL	SLC4A11	326	Q8NBS3
KGFLKEIRRSPSGID	TRIM32	401	Q13049
KTLRPRFKIIGGEFT	PLAU	171	P00749
RTKRKFSLDELAGPG	RNF8	151	O76064
SFSIRFGRKPSLIGL	PREX1	991	Q8TCU6
IFRKLRSSKPEGEAG	SIPA1L3	301	O60292
IKKHTLASGGRRFPF	SNCAIP	721	Q9Y6H5
FFRRKLIDAVGFSPL	SLC26A3	551	P40879
TGGRPKELSFARIKA	PHLDA3	46	Q9Y5J5
GKPRILSLGDFFFVR	ARID5B	31	Q14865
PDRAGSLELRGFKNK	ARAP1	441	Q96P48
LSRLTGGLKFFVPDI	CLCA2	456	Q9UQC9
AFFKGLVPSFLRLGS	UCP1	266	P25874
RTRALLQPGDFLKGF	PLEKHG5	411	O94827
IKPRLRFKAFSGEGQ	UBXN2B	206	Q14CS0
IGLSDFFFPKRKLLE	ROPN1L	206	Q96C74
ITFLKRGDPRFAGVR	RP1L1	36	Q8IWN7
KIERNPFAKGFRDTG	TBX22	271	Q9Y458
LTGRHKGPLAERDFK	TMPRSS9	136	Q7Z410
TRFLFILLGPSGRAK	SLC4A5	341	Q9BY07
KLFAKFGLRFDIRLP	POPDC2	251	Q9HBU9
KAPGLGAFRRKFIQT	PRKDC	3621	P78527
LFIRPDILRGAFKGL	ZNF536	831	O15090
IAPSFVKGFLLRDRG	YME1L1	231	Q96TA2
RGQHKKTLERLFPGF	ZSWIM8	461	A7E2V4
GNKLLETKGIPFRRF	ZNF462	421	Q96JM2
KSGGRSDLIPTIKFR	GINS1	51	Q14691
SGKSLFRFPKDRAVR	THAP10	16	Q9P2Z0
LRLFGDHFRAFKPLG	WDR87	91	Q6ZQQ6
DRFKEGIPGKSRSLV	ZNF79	61	Q15937
FRFEVLGLLRGSKLS	TRPC4	746	Q9UBN4
RKGTLNRDLLFDPLG	ZC3H7B	516	Q9UGR2
PKRKEGAGSLARFDF	VPS13D	2301	Q5THJ4