Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled serotonin receptor binding	GNAI1 GNAI3	8.25e-05	5	58	2	GO:0031821
GeneOntologyMolecularFunction	extracellularly glycine-gated ion channel activity	GLRA1 GLRA3	1.23e-04	6	58	2	GO:0016933
GeneOntologyMolecularFunction	extracellularly glycine-gated chloride channel activity	GLRA1 GLRA3	1.23e-04	6	58	2	GO:0016934
GeneOntologyMolecularFunction	inhibitory extracellular ligand-gated monoatomic ion channel activity	GLRA1 GLRA3	2.30e-04	8	58	2	GO:0005237
GeneOntologyMolecularFunction	structural constituent of muscle	CSRP2 DMD NEB	2.64e-04	43	58	3	GO:0008307
GeneOntologyMolecularFunction	vinculin binding	PXN DMD	6.34e-04	13	58	2	GO:0017166
GeneOntologyMolecularFunction	glycine binding	GLRA1 GLRA3	7.38e-04	14	58	2	GO:0016594
GeneOntologyMolecularFunction	lamin binding	LBR DMD	1.37e-03	19	58	2	GO:0005521
GeneOntologyMolecularFunction	GTPase activating protein binding	GNAI1 GNAI3	1.37e-03	19	58	2	GO:0032794
GeneOntologyMolecularFunction	chloride channel activity	GLRA1 GLRA3 CLCC1	2.01e-03	86	58	3	GO:0005254
GeneOntologyBiologicalProcess	vesicle fusion	SOX30 SPG11 GNAI3 FER1L5 DOC2B	4.52e-05	142	57	5	GO:0006906
GeneOntologyBiologicalProcess	organelle membrane fusion	SOX30 SPG11 GNAI3 FER1L5 DOC2B	4.84e-05	144	57	5	GO:0090174
GeneOntologyBiologicalProcess	muscle cell development	MYH10 CSRP2 SPG11 DMD NEB FER1L5	7.85e-05	259	57	6	GO:0055001
GeneOntologyBiologicalProcess	muscle cell differentiation	DOCK1 MYH10 CSRP2 SPG11 DMD NEB FER1L5 NOTCH2	9.98e-05	531	57	8	GO:0042692
GeneOntologyBiologicalProcess	positive regulation of cell cycle G2/M phase transition	NPM1 VPS4B SIN3A	1.03e-04	33	57	3	GO:1902751
GeneOntologyBiologicalProcess	striated muscle cell development	MYH10 CSRP2 DMD NEB	1.07e-04	89	57	4	GO:0055002
GeneOntologyBiologicalProcess	plasma membrane repair	MYH10 VPS4B FER1L5	1.13e-04	34	57	3	GO:0001778
GeneOntologyBiologicalProcess	organelle fusion	SOX30 SPG11 GNAI3 FER1L5 DOC2B	1.79e-04	190	57	5	GO:0048284
GeneOntologyBiologicalProcess	nucleus localization	TLK2 MYH10 DMD	2.45e-04	44	57	3	GO:0051647
MousePheno	decreased skeletal muscle fiber diameter	DOCK1 DMD NEB CLCC1	1.05e-05	42	46	4	MP:0009402
Domain	Glycine_rcpt_A	GLRA1 GLRA3	5.66e-05	4	58	2	IPR008127
Domain	Gprotein_alpha_I	GNAI1 GNAI3	2.62e-04	8	58	2	IPR001408
Domain	G-alpha	GNAI1 GNAI3	1.11e-03	16	58	2	PF00503
Domain	GproteinA_insert	GNAI1 GNAI3	1.11e-03	16	58	2	IPR011025
Domain	-	GNAI1 GNAI3	1.11e-03	16	58	2	1.10.400.10
Domain	G_alpha	GNAI1 GNAI3	1.11e-03	16	58	2	SM00275
Domain	Gprotein_alpha_su	GNAI1 GNAI3	1.25e-03	17	58	2	IPR001019
Domain	DEP	DEPTOR RGS11	2.10e-03	22	58	2	PF00610
Domain	DEP	DEPTOR RGS11	2.10e-03	22	58	2	PS50186
Domain	DEP	DEPTOR RGS11	2.10e-03	22	58	2	SM00049
Domain	DEP_dom	DEPTOR RGS11	2.30e-03	23	58	2	IPR000591
Domain	GABAA/Glycine_rcpt	GLRA1 GLRA3	2.30e-03	23	58	2	IPR006028
Domain	C2	FER1L5 SYT13 DOC2B	7.86e-03	131	58	3	PF00168
Domain	TPR_repeat	SPAG1 CDC16 AIP	8.19e-03	133	58	3	IPR019734
Domain	Neurotransmitter_ion_chnl_CS	GLRA1 GLRA3	8.61e-03	45	58	2	IPR018000
Domain	C2	FER1L5 SYT13 DOC2B	8.88e-03	137	58	3	SM00239
Domain	Neur_chan_memb	GLRA1 GLRA3	8.99e-03	46	58	2	PF02932
Domain	Neur_chan_LBD	GLRA1 GLRA3	9.37e-03	47	58	2	PF02931
Domain	NEUROTR_ION_CHANNEL	GLRA1 GLRA3	9.37e-03	47	58	2	PS00236
Domain	Neurotrans-gated_channel_TM	GLRA1 GLRA3	9.37e-03	47	58	2	IPR006029
Domain	-	GLRA1 GLRA3	9.37e-03	47	58	2	2.70.170.10
Domain	Neur_channel	GLRA1 GLRA3	9.37e-03	47	58	2	IPR006201
Domain	Neur_chan_lig-bd	GLRA1 GLRA3	9.37e-03	47	58	2	IPR006202
Domain	C2	FER1L5 SYT13 DOC2B	9.79e-03	142	58	3	PS50004
Domain	-	FER1L5 SYT13 DOC2B	1.09e-02	148	58	3	2.60.40.150
Domain	TPR-contain_dom	SPAG1 CDC16 AIP	1.13e-02	150	58	3	IPR013026
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_MECP2	SIN3A LBR	8.21e-05	5	41	2	MM15582
Pathway	WP_SEROTONIN_HTR1_GROUP_AND_FOS_PATHWAY	RASGRF1 GNAI1 GNAI3	1.66e-04	37	41	3	M42558
Pathway	PID_CXCR4_PATHWAY	VPS4B PXN GNAI1 GNAI3	1.97e-04	100	41	4	M124
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PROK2_TO_PROK_PRKR_GI_ERK_SIGNALING_PATHWAY	GNAI1 GNAI3	2.29e-04	8	41	2	M47642
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PROKR2_TO_PROK_PRKR_GI_ERK_SIGNALING_PATHWAY	GNAI1 GNAI3	2.29e-04	8	41	2	M47643
Pathway	KEGG_MEDICUS_REFERENCE_PROK_PRKR_GI_ERK_SIGNALING_PATHWAY	GNAI1 GNAI3	2.93e-04	9	41	2	M47641
Pathway	REACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION	RASGRF1 GLRA1 GLRA3 GNAI1 GNAI3	3.03e-04	205	41	5	M752
Pathway	PID_HEDGEHOG_GLI_PATHWAY	GNAI1 GNAI3 SIN3A	3.61e-04	48	41	3	M219
Pathway	KEGG_MEDICUS_ENV_FACTOR_NICOTINE_NNK_TO_PI3K_SIGNALING_PATHWAY	GNAI1 GNAI3	4.46e-04	11	41	2	M47797
Pathway	KEGG_MEDICUS_REFERENCE_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY	GNAI1 GNAI3	5.35e-04	12	41	2	M47558
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY	GNAI1 GNAI3	5.35e-04	12	41	2	M47559
Pathway	REACTOME_PTK6_REGULATES_RHO_GTPASES_RAS_GTPASE_AND_MAP_KINASES	DOCK1 PXN	6.31e-04	13	41	2	MM15484
Pathway	REACTOME_PTK6_REGULATES_RHO_GTPASES_RAS_GTPASE_AND_MAP_KINASES	DOCK1 PXN	7.35e-04	14	41	2	M27734
Pathway	PID_S1P_S1P4_PATHWAY	GNAI1 GNAI3	7.35e-04	14	41	2	M64
Pathway	REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY	GNAI1 GNAI3	7.35e-04	14	41	2	MM14669
Pathway	REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY	GNAI1 GNAI3	7.35e-04	14	41	2	M750
Pathway	REACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION	GLRA1 GLRA3 GNAI1 GNAI3	7.89e-04	144	41	4	MM14501
Pathway	PID_LYSOPHOSPHOLIPID_PATHWAY	PXN GNAI1 GNAI3	8.80e-04	65	41	3	M15
Pathway	KEGG_MEDICUS_REFERENCE_AUTOPHAGY_VESICLE_NUCLEATION_ELONGATION_MATURATION_MTORC1_PI3KC3_C1	DEPTOR NRBF2	9.65e-04	16	41	2	M47457
Pathway	REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES	RASGRF1 GLRA1 GLRA3 GNAI1 GNAI3	1.06e-03	270	41	5	M15514
Pathway	KEGG_MEDICUS_REFERENCE_CX3CR1_GNAI_AC_PKA_SIGNALING_PATHWAY	GNAI1 GNAI3	1.09e-03	17	41	2	M47544
Pathway	KEGG_VIRAL_MYOCARDITIS	MYH10 CD80 DMD	1.09e-03	70	41	3	M12294
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	NPM1 FRA10AC1 SPAG1 MYH10 HSPH1 ATG4C SPG11 RGS11 GNAI1 CHD6 GNAI3 DMD NEB CCDC191	7.63e-08	1442	58	14	35575683
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	DOCK1 NPM1 SERPINB7 RCHY1 CD80 UBTF ZNF92 GNAI3 NEB ZNF25 SPECC1 SYT13 CLCC1	1.62e-07	1293	58	13	15342556
Pubmed	Characterization of the glycinergic input to bipolar cells of the mouse retina.	GLRA1 GLRA3	2.73e-06	2	58	2	16420443
Pubmed	Probing glycine receptor stoichiometry in superficial dorsal horn neurones using the spasmodic mouse.	GLRA1 GLRA3	2.73e-06	2	58	2	21486794
Pubmed	Phosphorylation of α3 glycine receptors induces a conformational change in the glycine-binding site.	GLRA1 GLRA3	2.73e-06	2	58	2	23834509
Pubmed	Regulation of nucleolar chromatin by B23/nucleophosmin jointly depends upon its RNA binding activity and transcription factor UBF.	NPM1 UBTF	2.73e-06	2	58	2	20713446
Pubmed	The human genome encodes at least three non-allellic G proteins with alpha i-type subunits.	GNAI1 GNAI3	2.73e-06	2	58	2	2440724
Pubmed	Requirement of Gαi1 and Gαi3 in interleukin-4-induced signaling, macrophage M2 polarization and allergic asthma response.	GNAI1 GNAI3	2.73e-06	2	58	2	33754034
Pubmed	Multifunctional basic motif in the glycine receptor intracellular domain induces subunit-specific sorting.	GLRA1 GLRA3	2.73e-06	2	58	2	19959465
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	DOCK1 BROX VPS13D DEPTOR NRBF2 PXN LBR NOTCH2	2.94e-06	536	58	8	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	DOCK1 BROX VPS13D DEPTOR NRBF2 PXN LBR NOTCH2	3.03e-06	538	58	8	10512203
Pubmed	Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in splenocytes by Galphai proteins.	GNAI1 GNAI3	8.19e-06	3	58	2	16962188
Pubmed	The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway.	GNAI1 GNAI3	8.19e-06	3	58	2	8626678
Pubmed	NSP 5a3a's link to nuclear-cyto proteins B23 and hnRNP-L between normal and aberrant breast cell lines.	NPM1 SPECC1	8.19e-06	3	58	2	20237420
Pubmed	FGF13A interacts with NPM1 and UBF and inhibits the invasion of bladder cancer cells.	NPM1 UBTF	8.19e-06	3	58	2	37603967
Pubmed	Lipopolysaccharide- and gram-positive bacteria-induced cellular inflammatory responses: role of heterotrimeric Galpha(i) proteins.	GNAI1 GNAI3	8.19e-06	3	58	2	15788486
Pubmed	Genome-wide association study of urinary albumin excretion rate in patients with type 1 diabetes.	GLRA3 PSD3	8.19e-06	3	58	2	24595857
Pubmed	Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in macrophages by Galpha(i) proteins.	GNAI1 GNAI3	8.19e-06	3	58	2	17484771
Pubmed	Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K+ currents in adult murine atria.	GNAI1 GNAI3	8.19e-06	3	58	2	29342363
Pubmed	Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy.	GNAI1 GNAI3	8.19e-06	3	58	2	8504751
Pubmed	Diversity of glycine receptors in the mouse retina: localization of the alpha4 subunit.	GLRA1 GLRA3	8.19e-06	3	58	2	17154252
Pubmed	Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2.	CD80 CSRP2	8.19e-06	3	58	2	9286703
Pubmed	GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2.	GNAI1 GNAI3	8.19e-06	3	58	2	30836096
Pubmed	Antidepression action of BDNF requires and is mimicked by Gαi1/3 expression in the hippocampus.	GNAI1 GNAI3	8.19e-06	3	58	2	29507199
Pubmed	Glycinergic input of small-field amacrine cells in the retinas of wildtype and glycine receptor deficient mice.	GLRA1 GLRA3	8.19e-06	3	58	2	17920294
Pubmed	Gαi1 and Gαi3mediate VEGF-induced VEGFR2 endocytosis, signaling and angiogenesis.	GNAI1 GNAI3	8.19e-06	3	58	2	30279732
Pubmed	Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.	NPM1 MYH10 UBTF VPS4B HSPH1 GNAI1 SPECC1 CASZ1	9.15e-06	626	58	8	33644029
Pubmed	Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.	RGS11 DMD NEB	1.25e-05	27	58	3	18468998
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	CDC16 HSPH1 GNAI1 GNAI3 DMD NEB	1.62e-05	322	58	6	26514267
Pubmed	Most central nervous system D2 dopamine receptors are coupled to their effectors by Go.	GNAI1 GNAI3	1.64e-05	4	58	2	11248120
Pubmed	Glycinergic input of widefield, displaced amacrine cells of the mouse retina.	GLRA1 GLRA3	1.64e-05	4	58	2	19528249
Pubmed	Expression and mRNA splicing of glycine receptor subunits and gephyrin during neuronal differentiation of P19 cells in vitro, studied by RT-PCR and immunocytochemistry.	GLRA1 GLRA3	1.64e-05	4	58	2	9051263
Pubmed	Gαi1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis.	GNAI1 GNAI3	1.64e-05	4	58	2	37153740
Pubmed	Activation of glycine receptor phase-shifts the circadian rhythm in neuronal activity in the mouse suprachiasmatic nucleus.	GLRA1 GLRA3	1.64e-05	4	58	2	21486797
Pubmed	RGS10 is a selective activator of G alpha i GTPase activity.	GNAI1 GNAI3	1.64e-05	4	58	2	8774883
Pubmed	Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division.	GNAI1 GNAI3	1.64e-05	4	58	2	17635935
Pubmed	Mouse gene knockout and knockin strategies in application to alpha subunits of Gi/Go family of G proteins.	GNAI1 GNAI3	1.64e-05	4	58	2	11771389
Pubmed	Nucleolar retention of a translational C/EBPalpha isoform stimulates rDNA transcription and cell size.	NPM1 UBTF	1.64e-05	4	58	2	20075868
Pubmed	FAK phosphorylation at Tyr-925 regulates cross-talk between focal adhesion turnover and cell protrusion.	DOCK1 PXN	1.64e-05	4	58	2	21289086
Pubmed	Gαi1 and Gαi3 regulate macrophage polarization by forming a complex containing CD14 and Gab1.	GNAI1 GNAI3	1.64e-05	4	58	2	25825741
Pubmed	Insulin-like growth factor I receptor signaling and nuclear translocation of insulin receptor substrates 1 and 2.	UBTF IRS2	1.64e-05	4	58	2	12554758
Pubmed	CB1 receptor-G protein association. Subtype selectivity is determined by distinct intracellular domains.	GNAI1 GNAI3	1.64e-05	4	58	2	11168387
Pubmed	Combinatorial genetics reveals the Dock1-Rac2 axis as a potential target for the treatment of NPM1;Cohesin mutated AML.	DOCK1 NPM1	1.64e-05	4	58	2	35778533
Pubmed	Regulator of G protein signaling Z1 (RGSZ1) interacts with Galpha i subunits and regulates Galpha i-mediated cell signaling.	GNAI1 GNAI3	1.64e-05	4	58	2	12379657
Pubmed	Alpha subunit-dependent glycine receptor clustering and regulation of synaptic receptor numbers.	GLRA1 GLRA3	1.64e-05	4	58	2	28883437
Pubmed	Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells.	GNAI1 GNAI3	1.64e-05	4	58	2	1902575
Pubmed	The role of inhibitory heterotrimeric G proteins in the control of in vivo heart rate dynamics.	GNAI1 GNAI3	1.64e-05	4	58	2	18832081
Pubmed	Analysis of RGSZ1 protein interaction with Galphai subunits.	GNAI1 GNAI3	1.64e-05	4	58	2	15488169
Pubmed	Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP.	GNAI1 GNAI3	1.64e-05	4	58	2	10364213
Pubmed	Specific interaction of Gαi3 with the Oa1 G-protein coupled receptor controls the size and density of melanosomes in retinal pigment epithelium.	GNAI1 GNAI3	1.64e-05	4	58	2	21931697
Pubmed	The cysteine-rich protein family of highly related LIM domain proteins.	CD80 CSRP2	1.64e-05	4	58	2	7499425
Pubmed	Coupling of Airway Smooth Muscle Bitter Taste Receptors to Intracellular Signaling and Relaxation Is via Gαi1,2,3.	GNAI1 GNAI3	1.64e-05	4	58	2	28145731
Pubmed	GIV/Girdin activates Gαi and inhibits Gαs via the same motif.	GNAI1 GNAI3	1.64e-05	4	58	2	27621449
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	KIF21B VPS13D UBTF HSPH1 SPG11 IRS2 NEB	1.87e-05	497	58	7	36774506
Pubmed	Oxidized human neuroglobin acts as a heterotrimeric Galpha protein guanine nucleotide dissociation inhibitor.	GNAI1 GNAI3	2.72e-05	5	58	2	12860983
Pubmed	Developmental regulation of glycine receptors at efferent synapses of the murine cochlea.	GLRA1 GLRA3	2.72e-05	5	58	2	21850450
Pubmed	Coupling of dopamine receptor subtypes to multiple and diverse G proteins.	GNAI1 GNAI3	2.72e-05	5	58	2	10978845
Pubmed	An essential role for Gα(i2) in Smoothened-stimulated epithelial cell proliferation in the mammary gland.	GNAI1 GNAI3	2.72e-05	5	58	2	26373672
Pubmed	G-protein alpha subunit interaction and guanine nucleotide dissociation inhibitor activity of the dual GoLoco motif protein PCP-2 (Purkinje cell protein-2).	GNAI1 GNAI3	2.72e-05	5	58	2	16298104
Pubmed	Defective macrophage migration in Gαi2- but not Gαi3-deficient mice.	GNAI1 GNAI3	2.72e-05	5	58	2	22706085
Pubmed	Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium.	GNAI1 GNAI3	2.72e-05	5	58	2	2820999
Pubmed	GINIP, a Gαi-interacting protein, functions as a key modulator of peripheral GABAB receptor-mediated analgesia.	GNAI1 GNAI3	2.72e-05	5	58	2	25242222
Pubmed	ABH2 couples regulation of ribosomal DNA transcription with DNA alkylation repair.	NPM1 UBTF	2.72e-05	5	58	2	23972994
Pubmed	Estrogen- and xenoestrogen-induced ERK signaling in pituitary tumor cells involves estrogen receptor-α interactions with G protein-αi and caveolin I.	GNAI1 GNAI3	2.72e-05	5	58	2	22230296
Pubmed	RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity.	GNAI1 GNAI3	2.72e-05	5	58	2	11387333
Pubmed	HIV-1 triggers WAVE2 phosphorylation in primary CD4 T cells and macrophages, mediating Arp2/3-dependent nuclear migration.	GNAI1 GNAI3	2.72e-05	5	58	2	24415754
Pubmed	Native glycine receptor subtypes and their physiological roles.	GLRA1 GLRA3	2.72e-05	5	58	2	18721822
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	NPM1 JADE3 IGKC IRS2 NEB	2.96e-05	214	58	5	22199357
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	NPM1 MYH10 VPS4B HSPH1 PXN GNAI1 GNAI3 LBR SPECC1 ZC3H6	3.69e-05	1247	58	10	27684187
Pubmed	Requirement of Gαi1/3-Gab1 signaling complex for keratinocyte growth factor-induced PI3K-AKT-mTORC1 activation.	GNAI1 GNAI3	4.08e-05	6	58	2	25078664
Pubmed	Identification of the platelet ADP receptor targeted by antithrombotic drugs.	GNAI1 GNAI3	4.08e-05	6	58	2	11196645
Pubmed	Gialpha and Gbeta subunits both define selectivity of G protein activation by alpha2-adrenergic receptors.	GNAI1 GNAI3	4.08e-05	6	58	2	16371464
Pubmed	Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.	GNAI1 GNAI3	4.08e-05	6	58	2	18434541
Pubmed	Development of the mammalian axial skeleton requires signaling through the Gα(i) subfamily of heterotrimeric G proteins.	GNAI1 GNAI3	4.08e-05	6	58	2	23236180
Pubmed	Galpha(i1) and Galpha(i3) are required for epidermal growth factor-mediated activation of the Akt-mTORC1 pathway.	GNAI1 GNAI3	4.08e-05	6	58	2	19401591
Pubmed	Intrinsic planar polarity mechanisms influence the position-dependent regulation of synapse properties in inner hair cells.	GNAI1 GNAI3	4.08e-05	6	58	2	30975754
Pubmed	Cloning and characterization of a novel regulator of G protein signalling in human platelets.	GNAI1 GNAI3	4.08e-05	6	58	2	11955952
Pubmed	ICOS maintains the T follicular helper cell phenotype by down-regulating Krüppel-like factor 2.	CD80 IGKC	4.08e-05	6	58	2	25646266
Pubmed	Characterization of RGS5 in regulation of G protein-coupled receptor signaling.	GNAI1 GNAI3	4.08e-05	6	58	2	11253162
Pubmed	Glycine receptors support excitatory neurotransmitter release in developing mouse visual cortex.	GLRA1 GLRA3	5.71e-05	7	58	2	22988142
Pubmed	CCL3, acting via the chemokine receptor CCR5, leads to independent activation of Janus kinase 2 (JAK2) and Gi proteins.	GNAI1 GNAI3	5.71e-05	7	58	2	15251452
Pubmed	Activation state-dependent interaction between Galphai and p67phox.	GNAI1 GNAI3	5.71e-05	7	58	2	16782902
Pubmed	Global/temporal gene expression in diaphragm and hindlimb muscles of dystrophin-deficient (mdx) mice.	DMD NEB	5.71e-05	7	58	2	12176734
Pubmed	GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits.	GNAI1 GNAI3	5.71e-05	7	58	2	8986788
Pubmed	Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry.	NPM1 MYH10 CDC16 HSPH1 GNAI1 GNAI3	6.33e-05	411	58	6	36652389
Pubmed	The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.	ZNF117 ZNF92	7.60e-05	8	58	2	2023909
Pubmed	Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor.	GNAI1 GNAI3	7.60e-05	8	58	2	12509430
Pubmed	The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration.	DOCK1 PXN	7.60e-05	8	58	2	15728191
Pubmed	Regulation of ubiquitin ligase dynamics by the nucleolus.	NPM1 UBTF	7.60e-05	8	58	2	16129783
Pubmed	Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling.	GNAI1 GNAI3	7.60e-05	8	58	2	26126266
Pubmed	C-terminal SH3 domain of CrkII regulates the assembly and function of the DOCK180/ELMO Rac-GEF.	DOCK1 PXN	7.60e-05	8	58	2	15700267
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	NPM1 SPAG1 MYH10 NANP HSPH1 CSRP2 GNAI1 GNAI3 SIN3A CLCC1	7.96e-05	1367	58	10	32687490
Pubmed	Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis.	GNAI1 GNAI3	9.77e-05	9	58	2	38651641
Pubmed	The Src homology and collagen A (ShcA) adaptor protein is required for the spatial organization of the costamere/Z-disk network during heart development.	PXN DMD	9.77e-05	9	58	2	25488665
Pubmed	Tbx1 regulates extracellular matrix-cell interactions in the second heart field.	MYH10 PXN	1.22e-04	10	58	2	31180501
Pubmed	The LGN protein promotes planar proliferative divisions in the neocortex but apicobasal asymmetric terminal divisions in the retina.	GNAI1 GNAI3	1.22e-04	10	58	2	26755700
Pubmed	The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families.	GNAI1 GNAI3	1.22e-04	10	58	2	8552586
Pubmed	The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2.	GNAI1 GNAI3	1.22e-04	10	58	2	8521505
Pubmed	Systematic identification of factors for provirus silencing in embryonic stem cells.	NPM1 CDC16 HSPH1 SIN3A	1.27e-04	153	58	4	26365490
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	TLK2 JADE3 CDC16 HSPH1 PXN SIN3A AIP SPECC1	1.28e-04	910	58	8	36736316
Cytoband	18q21.33	SERPINB7 VPS4B	1.86e-04	16	58	2	18q21.33
Cytoband	15q24.2	RASGRF1 SIN3A	7.59e-04	32	58	2	15q24.2
Cytoband	1p36.22	VPS13D CASZ1	1.02e-03	37	58	2	1p36.22
Cytoband	1p31.3	RAVER2 ATG4C	1.92e-03	51	58	2	1p31.3
Cytoband	13q34	CDC16 IRS2	2.15e-03	54	58	2	13q34
Cytoband	7q11.21	ZNF117 ZNF92	5.00e-03	83	58	2	7q11.21
Cytoband	Ensembl 112 genes in cytogenetic band chr13q34	CDC16 IRS2	5.60e-03	88	58	2	chr13q34
GeneFamily	Glycine receptors	GLRA1 GLRA3	4.75e-05	5	40	2	868
ToppCell	3'_v3-Lung-Lymphocytic_B-Memory_B_cells\|Lung / Manually curated celltypes from each tissue	JADE3 IGKC GLRA3 VWC2L CDH15	2.91e-06	171	58	5	9ecef653f6916572bf5fbee5aea6c577d04e96ba
ToppCell	(2)_Fibroblasts-(21)_Fibro-2\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	RASGRF1 CD80 RAVER2 DMD DOC2B	4.99e-06	191	58	5	5ee353c79055c08e8a3e2b43a0345bceb09f3890
ToppCell	Healthy-B_intermediate\|Healthy / disease group, cell group and cell class	RASGRF1 IGKC DMD NEB CCDC191	5.39e-06	194	58	5	aabee48bf689367edae2079b4b90d253715f1097
ToppCell	Healthy-B_intermediate\|World / disease group, cell group and cell class	RASGRF1 IGKC DMD NEB CCDC191	5.52e-06	195	58	5	9de79e0bdd9063ae65e5edb89cc3fe6f9a8173bc
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal-Mesoderm\|6m / Sample Type, Dataset, Time_group, and Cell type.	DEPTOR PXN DMD NEB CDH15	6.25e-06	200	58	5	0f6851baf0cf2a8b0c95a7a585c4407c330c5f6c
ToppCell	mild_COVID-19_(asymptomatic)-B_intermediate\|World / disease group, cell group and cell class (v2)	RASGRF1 CD80 IGKC DMD	5.63e-05	160	58	4	6722934e153b72039c3c4308557d0ef879a30638
ToppCell	3'_v3-bone_marrow-Lymphocytic_B-ABC_aged-B_memory\|bone_marrow / Manually curated celltypes from each tissue	RASGRF1 CD80 IGKC GLRA3	6.05e-05	163	58	4	30f5c93c4e170304d701b5231f0d545f404066f7
ToppCell	LV-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	FRY CSRP2 DMD SPECC1	6.34e-05	165	58	4	f37fd95adc95d7753cf6e55ae819976513c7ec77
ToppCell	368C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	KIF21B BROX FRY MYH10	6.96e-05	169	58	4	0589f39d8e9468e42d25d30ff70bb7cb8b921628
ToppCell	ILEUM-non-inflamed-(3)_MNP-(3)_mature_DC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	JADE3 CD80 PSD3 CASZ1	7.28e-05	171	58	4	341f9f79c1ed654ab347e25dc4936f89ffdf9617
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_10\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RASGRF1 JADE3 CD80 PSD3	7.62e-05	173	58	4	09a13407a41ff2cba82fc417b72bf9a24ce6c42e
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_10\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	RASGRF1 JADE3 CD80 PSD3	7.62e-05	173	58	4	bfec038a6783f166240da4861e100643c6ea80a5
ToppCell	3'_v3-bone_marrow-Lymphocytic_B-GC_B_(I)\|bone_marrow / Manually curated celltypes from each tissue	ZNF117 JADE3 CD80 GLRA3	7.62e-05	173	58	4	67f0f0bf88eab69987b71d96b864ed2b14975adb
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_A2\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	FRY IGKC CSRP2 CLCC1	7.96e-05	175	58	4	da191dfb8a7f976a632a3a0b923942ab54f5c8c1
ToppCell	IIF-Lymphocyte-B-B_intermediate\|IIF / Disease, Lineage and Cell Type	JADE3 CD80 IGKC CCDC191	7.96e-05	175	58	4	327f8ee3669c3fc5ba50abc3b4f3e068637fd8d8
ToppCell	Healthy-B_memory\|Healthy / disease group, cell group and cell class	CD80 IGKC GLRA3 CCDC191	9.07e-05	181	58	4	7b903076efb90026b9845af0c7a840901451193a
ToppCell	VE-matDC-\|VE / Condition, Cell_class and T cell subcluster	RASGRF1 CD80 PSD3 DMD	9.07e-05	181	58	4	6252184ef098b911df50be4fe1b5565849a5b6b8
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYH10 DEPTOR RGS11 CASZ1	9.07e-05	181	58	4	22363c5835dd6cef8f895ab9362e0837d92b15b1
ToppCell	VE-matDC\|VE / Condition, Cell_class and T cell subcluster	RASGRF1 CD80 PSD3 DMD	9.07e-05	181	58	4	982fd96ef75bc9ab2c2f4970c01b76ba7a164871
ToppCell	RA-13._Vascular_Smooth_Muscle\|RA / Chamber and Cluster_Paper	FRY MYH10 DMD SPECC1	9.47e-05	183	58	4	818fd886e0188091310825f9145fa53328f2c979
ToppCell	3'_v3-blood-Lymphocytic_B-Memory_B_cells\|blood / Manually curated celltypes from each tissue	RASGRF1 JADE3 CD80 IGKC	9.47e-05	183	58	4	e3a418b745d7f040adf47be9e1043b945cae47ed
ToppCell	RA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	FRY MYH10 DMD SPECC1	9.47e-05	183	58	4	cae2ee08f985a6f005b4b8e959e465350315156a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MYH10 DEPTOR GNAI1 CASZ1	9.67e-05	184	58	4	8fd8bd3d28d0ee6f0ef1f14e354d8eaf63a8081b
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF1 PSD3 VWC2L SYT13	9.87e-05	185	58	4	70de48988c1f8e0809afc8092b663aa439d8e528
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	RCHY1 HSPH1 IRS2 AIP	1.01e-04	186	58	4	ed9b1a784f67e8a297e2a10993a6d97df60581ac
ToppCell	3'_v3-blood-Lymphocytic_B\|blood / Manually curated celltypes from each tissue	RASGRF1 JADE3 CD80 IGKC	1.01e-04	186	58	4	5624b1fc7eab9f505588fcc86a24d14f8bcbfef7
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-Granular_Neuron_CB_Gabra6\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF1 PSD3 VWC2L SYT13	1.01e-04	186	58	4	d6c8ce2a32c218dcc63d861cc247152430ed3c8c
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-10\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	JADE3 CD80 DMD NEB	1.01e-04	186	58	4	d7d884ff4184636081c350d29f797bd923c6a3b4
ToppCell	droplet-Liver-LIVER_HEP-30m-Lymphocytic-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH10 GNAI1 IRS2 SYT13	1.01e-04	186	58	4	f5468e03321ea2083e223eb0d92c3a9307039569
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FRY MYH10 CASZ1 DOC2B	1.03e-04	187	58	4	f6217d0dd425eac76900b44a4e48f45475f3ac36
ToppCell	COVID-19_Severe-B_memory\|World / disease group, cell group and cell class	CD80 ZNF92 IGKC GLRA3	1.03e-04	187	58	4	f29c71f2505bb64f3010ada491d422b87a6f7db3
ToppCell	LA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	PSD3 DMD NEB CASZ1	1.05e-04	188	58	4	6d249fe92d51a19da19ec14bb2262d394255d577
ToppCell	COPD-Stromal-SMC\|Stromal / Disease state, Lineage and Cell class	FRY CSRP2 DMD SPECC1	1.05e-04	188	58	4	9ffef4b01d0ddd6913c9ed6be79aeaaabd5e41ed
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_memory-B_memory-0\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NPM1 JADE3 CD80 IGKC	1.05e-04	188	58	4	229108e7e3db49e1cfd747d69e338394139d95b3
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRY MYH10 CASZ1 DOC2B	1.05e-04	188	58	4	e30a4ddac0da8cdcf621d98e28e3895cd9307e7a
ToppCell	LA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	FRY MYH10 DMD SPECC1	1.07e-04	189	58	4	6b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCell	Healthy-B_naive\|World / disease group, cell group and cell class	RASGRF1 IGKC DMD CCDC191	1.07e-04	189	58	4	1e533a43f739ff295740cf2b25479756dfb8e595
ToppCell	10x5'-bone_marrow-Lymphocytic_B-Memory_B_cells\|bone_marrow / Manually curated celltypes from each tissue	RASGRF1 JADE3 CD80 IGKC	1.12e-04	191	58	4	67479df0ca4c5a792fd604aded3f75609fec0888
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-0\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	JADE3 IGKC DMD CCDC191	1.12e-04	191	58	4	5a9a592875fbd0b1429b48db29a760fdc9c2c856
ToppCell	COVID-19_Severe-B_intermediate\|World / disease group, cell group and cell class	JADE3 CD80 IGKC DMD	1.12e-04	191	58	4	f226fd69a26124ba98e4544f550b89a08e6a3708
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_intermediate\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	JADE3 CD80 IGKC DMD	1.16e-04	193	58	4	7cc10e8b51091869d46e462f3214999e7b5348b1
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_10\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	RASGRF1 CD80 CSRP2 SPECC1	1.16e-04	193	58	4	a2194012dfa0174c6160900625c44e0fd04c50e7
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF1 GLRA3 VWC2L SYT13	1.16e-04	193	58	4	461919ab422bc9d1fcff7a3a4757c75239041d7e
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_10\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RASGRF1 CD80 CSRP2 SPECC1	1.16e-04	193	58	4	7426a30ed01e5c8376b3e0ebe0f1057cfee88340
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF1 GLRA3 VWC2L SYT13	1.16e-04	193	58	4	0dd810ad900d3e586551622b2c1de39d76fd6a7f
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_intermediate\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	JADE3 CD80 IGKC DMD	1.19e-04	194	58	4	2b61023a602d336ed0de174e9141046173db34e6
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRY MYH10 CSRP2 DMD	1.19e-04	194	58	4	5c3b2b05d1e4f146551fe4c920263d8e6ca34de3
ToppCell	RA-03._Atrial_Cardiomyocyte\|RA / Chamber and Cluster_Paper	FRY PSD3 DMD CASZ1	1.19e-04	194	58	4	c3535f7cc0076653c72db582047cff053c322397
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRY MYH10 CSRP2 DMD	1.19e-04	194	58	4	ab9cad697f9209d2889bc02b43b502dfeb2ebfef
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_intermediate-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	JADE3 CD80 IGKC DMD	1.19e-04	194	58	4	f2486b19ac52a48d19f80b38a5536bee3dad745b
ToppCell	COVID-19_Severe-B_memory\|COVID-19_Severe / disease group, cell group and cell class	NPM1 CD80 ZNF92 GLRA3	1.21e-04	195	58	4	54becd9e283639638fc5f13eddce224aed9391da
ToppCell	mild_COVID-19_(asymptomatic)-B_naive\|World / disease group, cell group and cell class (v2)	ZNF92 IGKC DMD CCDC191	1.21e-04	195	58	4	e763d9a431052c03cc6d514f2736506c6667e2be
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	FRY PSD3 DMD CASZ1	1.21e-04	195	58	4	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Mesenchymal-skeletal_muscle_satellite_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DEPTOR DMD CDH15 NOTCH2	1.23e-04	196	58	4	97ac47daf5bb07fa5dda3976e1ae402750f959b5
ToppCell	Leuk-UTI-Myeloid-cDC2\|Leuk-UTI / Disease, Lineage and Cell Type	NPM1 DEPTOR ATG4C SPECC1	1.23e-04	196	58	4	50465a082f03201936733c55af73bc32e1bdd024
ToppCell	COVID-19_Mild-cDC\|COVID-19_Mild / Disease condition and Cell class	NPM1 DEPTOR IGKC SPECC1	1.26e-04	197	58	4	09045845891de79164124afb6c632e2838906006
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Layer_VI_Pan-area\|World / Primary Cells by Cluster	RASGRF1 PSD3 DMD SYT13	1.26e-04	197	58	4	79b9e7f2e8e33b3c547f716be5667156c48b0dfc
ToppCell	10x3'2.3-week_17-19\|World / cell types per 3 fetal stages;per 3',per 5'	ZNF92 HSPH1 IGKC IRS2	1.26e-04	197	58	4	f5cfad0b42d0f817e22cc78b9bfb2b4b7e4330ed
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NPM1 SERPINB7 HSPH1 CSRP2	1.26e-04	197	58	4	2a90422ba400b951517603a916f34221056d0f3d
ToppCell	mild_COVID-19-B_intermediate\|mild_COVID-19 / disease group, cell group and cell class (v2)	JADE3 CD80 IGKC DMD	1.26e-04	197	58	4	f669500120646f69355a6f920b892a6f2faeab63
ToppCell	COVID-19_Mild-cDC-\|COVID-19_Mild / Disease condition and Cell class	NPM1 DEPTOR IGKC SPECC1	1.26e-04	197	58	4	61d6dd023b2ba2bc76f17c06f7c30434ed865171
ToppCell	mild_COVID-19-B_intermediate\|World / disease group, cell group and cell class (v2)	JADE3 CD80 IGKC DMD	1.26e-04	197	58	4	e909b898b7458071f176b6c04356ea3540589153
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Layer_VI_Pan-area-33\|World / Primary Cells by Cluster	RASGRF1 PSD3 DMD SYT13	1.26e-04	197	58	4	d20f29088e9afd8a960d6f680075c380e550f8a7
ToppCell	COVID-19-Myeloid-Migratory_DC\|COVID-19 / Condition, Lineage and Cell class	RASGRF1 CD80 CSRP2 SPECC1	1.26e-04	197	58	4	b6d6cdae33753c1e38394f1f879e00b87f9c0496
ToppCell	Transplant_Alveoli_and_parenchyma-Mesenchymal-Smooth_muscle\|Mesenchymal / Tissue, Lineage and Cell class of Lung Cells from 10X	FRY MYH10 CSRP2 DMD	1.28e-04	198	58	4	89986c7756541df364df516329d10775ba0e78a4
ToppCell	Sepsis-ICU-SEP-Lymphocyte-B-B_memory\|ICU-SEP / Disease, condition lineage and cell class	NPM1 CD80 IGKC GLRA3	1.28e-04	198	58	4	4ba2eb32889bbf043f4bbb822e08eb45a2b576ef
ToppCell	Tracheal-10x3prime_v2-Stromal-Fibroblastic-Fibro_myofibroblast\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	MYH10 CSRP2 RGS11 CDH15	1.28e-04	198	58	4	08d393853e195a7eacace454153e425a273e2d23
ToppCell	COVID-19-Myeloid-Migratory_DC\|Myeloid / Condition, Lineage and Cell class	CD80 CSRP2 DMD SPECC1	1.28e-04	198	58	4	90f3b227cbc61c268d6d94bc9945a08d83d2d3d5
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-B-B_intermediate\|COVID-19_Mild / Disease, condition lineage and cell class	JADE3 CD80 IGKC DMD	1.31e-04	199	58	4	1c6a08d01f6c1a2a4b6587d3a4522efbd03275e1
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Mesenchymal-Mesoderm\|3m / Sample Type, Dataset, Time_group, and Cell type.	DEPTOR NEB CASZ1 CDH15	1.33e-04	200	58	4	538ae964db58c4acafe93f735b3e03fc08fdaac6
ToppCell	Tracheal\|World / Cell types per location group and 10X technology with lineage, and cell group designations	DEPTOR RAVER2 PSD3 DMD	1.33e-04	200	58	4	682960e28542a3d6c119047cd0131941932cfdea
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Neuronal\|6m / Sample Type, Dataset, Time_group, and Cell type.	KIF21B CSRP2 GNAI1 SYT13	1.33e-04	200	58	4	cedbc47b1defb5973cf7ab6baaa2d6f2fd481f88
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Neuronal-Cortical_neuron\|6m / Sample Type, Dataset, Time_group, and Cell type.	KIF21B CSRP2 GNAI1 SYT13	1.33e-04	200	58	4	6f7ff0533339fcc9d316f2c77334a79c1409ec4f
ToppCell	Sepsis-Leuk-UTI-Myeloid-cDC2\|Leuk-UTI / Disease, condition lineage and cell class	NPM1 DEPTOR ATG4C SPECC1	1.33e-04	200	58	4	1f1611c590230cd50b9bdca6b58291ab3aab85f2
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SERPINB7 SOX30 GLRA3	1.39e-04	77	58	3	a799ccdb84014e978d9fbccf3d2fee8fbeac7b0c
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Calb2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SERPINB7 SOX30 GLRA3	1.50e-04	79	58	3	03c5af851b53800eced1c74e9da374c71092bcd4
ToppCell	(53)_Lymphoid_DC\|World / shred on Cell_type and subtype	RASGRF1 CD80 PSD3 DMD	1.55e-04	208	58	4	30212cfacad94a7cc562a69efa73a31259851515
Computational	Neighborhood of ERCC4	DOCK1 FRY JADE3 GLRA3 IRS2 DMD NEB	7.85e-05	321	36	7	MORF_ERCC4
Computational	Neighborhood of PTPRR	JADE3 GLRA3 DMD NEB	3.57e-04	102	36	4	MORF_PTPRR
Computational	AcetylCholine receptors.	GLRA1 GLRA3	9.68e-04	14	36	2	MODULE_328
Computational	Neighborhood of CDH4	JADE3 GLRA3 DMD NEB	1.05e-03	136	36	4	MORF_CDH4
Computational	Neurotransmitter (GABA) receptor.	GLRA1 GLRA3	1.11e-03	15	36	2	MODULE_215
Computational	Genes in the cancer module 267.	GLRA1 GLRA3	1.11e-03	15	36	2	MODULE_267
Drug	iso-THAZ	GLRA1 GLRA3	3.81e-05	4	58	2	CID003047783
Drug	protostrychnine	GLRA1 GLRA3	3.81e-05	4	58	2	CID005320746
Drug	7-nitroindoline	GLRA1 GLRA3	3.81e-05	4	58	2	CID013566747
Drug	2-(phosphonomethyl)phenylalanine	GLRA1 GLRA3	3.81e-05	4	58	2	CID000383689
Drug	SC-49648	GLRA1 GLRA3	3.81e-05	4	58	2	CID000195696
Drug	akuammiline	GLRA1 GLRA3	3.81e-05	4	58	2	CID005367018
Drug	NSC381080	GLRA1 GLRA3	3.81e-05	4	58	2	CID000165497
Drug	N-methyl-THIP	GLRA1 GLRA3	3.81e-05	4	58	2	CID000134373
Drug	SC-48981	GLRA1 GLRA3	3.81e-05	4	58	2	CID000126573
Drug	SC-50132	GLRA1 GLRA3	3.81e-05	4	58	2	CID000195719
Drug	SR 42641	GLRA1 GLRA3	3.81e-05	4	58	2	CID000129049
Drug	azetidine-3-carboxylic acid	GLRA1 GLRA3	6.35e-05	5	58	2	CID000093192
Drug	Lindane	GLRA1 GLRA3	6.35e-05	5	58	2	DB00431
Drug	Cao C	GLRA1 GLRA3	6.35e-05	5	58	2	CID000166617
Drug	oxanilide	GLRA1 GLRA3	6.35e-05	5	58	2	CID000069288
Drug	iso-THAO	GLRA1 GLRA3	6.35e-05	5	58	2	CID000127199
Drug	ALX1393	GLRA1 GLRA3	6.35e-05	5	58	2	CID016078939
Drug	pleiocarpamine	GLRA1 GLRA3	6.35e-05	5	58	2	CID000558637
Drug	mafoprazine	GLRA1 GLRA3	6.35e-05	5	58	2	CID000071241
Drug	gevotroline	GLRA1 GLRA3	6.35e-05	5	58	2	CID000060546
Drug	THAZ	GLRA1 GLRA3	9.50e-05	6	58	2	CID000171289
Drug	mV GABA	GLRA1 GLRA3	9.50e-05	6	58	2	CID000128435
Drug	caged glycine	GLRA1 GLRA3	9.50e-05	6	58	2	CID000192642
Drug	brometone	GLRA1 GLRA3	9.50e-05	6	58	2	CID000006424
Drug	minaxolone	GLRA1 GLRA3	9.50e-05	6	58	2	CID000071960
Drug	thiomuscimol	GLRA1 GLRA3	9.50e-05	6	58	2	CID000005448
Drug	thio-THIP	GLRA1 GLRA3	9.50e-05	6	58	2	CID000656720
Drug	AC1L90PQ	GLRA1 GLRA3	9.50e-05	6	58	2	CID000436036
Drug	15d-PGJ2; Up 200; 10uM; PC3; HT_HG-U133A	VPS13D HSPH1 RAVER2 IRS2 CDH15	1.03e-04	183	58	5	4455_UP
Drug	alpha-EMTBL	GLRA1 GLRA3	1.33e-04	7	58	2	CID000128423
Drug	CID189778	GLRA1 GLRA3	1.33e-04	7	58	2	CID000189778
Drug	propyl methanethiosulfonate	GLRA1 GLRA3	1.33e-04	7	58	2	CID000529387
Drug	thiocolchicoside	GLRA1 GLRA3	1.33e-04	7	58	2	CID000072067
Drug	L-serinamide	GLRA1 GLRA3	1.33e-04	7	58	2	CID000101138
Drug	Boc-glycine	GLRA1 GLRA3	1.33e-04	7	58	2	CID000078288
Drug	PK 8165	GLRA1 GLRA3	1.33e-04	7	58	2	CID000071219
Drug	Iohexol [66108-95-0]; Up 200; 4.8uM; MCF7; HT_HG-U133A	RASGRF1 SOX30 PSD3 SYT13 NOTCH2	1.42e-04	196	58	5	5704_UP
Drug	AC1OC6D1	NPM1 GLRA1 GLRA3 SIN3A	1.44e-04	104	58	4	CID006368594
Drug	Cinnarizine [298-57-7]; Up 200; 10.8uM; MCF7; HT_HG-U133A	VPS13D RCHY1 PXN IRS2 NOTCH2	1.46e-04	197	58	5	7174_UP
Drug	Vincamine [1617-90-9]; Up 200; 11.2uM; MCF7; HT_HG-U133A	VPS13D ZNF117 GLRA3 IRS2 SYT13	1.49e-04	198	58	5	3865_UP
Drug	WT702	GLRA1 GLRA3	1.77e-04	8	58	2	CID000089643
Drug	isostrychnine	GLRA1 GLRA3	1.77e-04	8	58	2	CID000264626
Drug	Atonik	GLRA1 GLRA3	2.27e-04	9	58	2	CID000069471
Drug	nortropanol	GLRA1 GLRA3	2.27e-04	9	58	2	CID000068147
Drug	AC1NSJX8	GLRA1 GLRA3	2.27e-04	9	58	2	CID005311059
Drug	NSC129536	GLRA1 GLRA3	2.27e-04	9	58	2	CID000004815
Drug	SR 57227A	GLRA1 GLRA3	2.27e-04	9	58	2	CID000131746
Drug	DCQX	GLRA1 GLRA3	2.27e-04	9	58	2	CID000001845
Disease	urinary albumin excretion rate, type 1 diabetes mellitus	GLRA3 PSD3	3.41e-06	2	55	2	EFO_0005667, MONDO_0005147
Disease	McCune Albright syndrome (implicated_via_orthology)	GNAI1 GNAI3	9.48e-05	8	55	2	DOID:1858 (implicated_via_orthology)
Disease	Aqueductal Stenosis	MYH10 SIN3A	9.48e-05	8	55	2	C2936786
Disease	Amnesia	GNAI1 GNAI3	4.56e-04	17	55	2	C0002622
Disease	Tactile Amnesia	GNAI1 GNAI3	4.56e-04	17	55	2	C0750906
Disease	Amnestic State	GNAI1 GNAI3	4.56e-04	17	55	2	C0750907
Disease	Dissociative Amnesia	GNAI1 GNAI3	4.56e-04	17	55	2	C0236795
Disease	Global Amnesia	GNAI1 GNAI3	4.56e-04	17	55	2	C0262497
Disease	Hysterical amnesia	GNAI1 GNAI3	4.56e-04	17	55	2	C0233750
Disease	Temporary Amnesia	GNAI1 GNAI3	4.56e-04	17	55	2	C0233796
Disease	longitudinal BMI measurement	DOCK1 ZNF257 PSD3	4.89e-04	82	55	3	EFO_0005937
Disease	diet measurement, body mass index	DOCK1 FRA10AC1	6.34e-04	20	55	2	EFO_0004340, EFO_0008111
Disease	insulin measurement	PSD3 IRS2 CHD6 CASZ1	1.56e-03	267	55	4	EFO_0004467

Protein segments in the cluster

Peptide	Gene	Start	Entry
KLHYCLDYDCQKAEL	SYT13	161	Q7L8C5
DIEKHKSYHIKDDAY	CASZ1	626	Q86V15
KVEKDYSYLKEICDH	SPECC1	621	Q5M775
LCKAHLEDKYRYLFK	DMD	3206	P11532
CVVLKYEKDAFKREH	CD80	116	P33681
KCYHFKYEDEDKTLP	ATG4C	46	Q96DT6
KEAAAKYYDAIACLK	AIP	196	O00170
CELKADKDYHFKVDN	NPM1	21	P06748
HDLLKDYDLKYCYVD	RAVER2	86	Q9HCJ3
YEKDCYDRLHKKINH	RGS11	141	O94810
IHEAGYSEEECKQYK	GNAI1	56	P63096
LLKEEKDLRYCTKHY	GLRA3	221	O75311
VHREARDEYHCKKKY	LBR	581	Q14739
KTCKYDKYCADHFKD	NOTCH2	1501	Q04721
IHEDGYSEDECKQYK	GNAI3	56	P08754
VEHFCAEFKTKYKLD	HSPH1	241	Q92598
YDKLFKEYCIADLSK	FRA10AC1	136	Q70Z53
ECYTEEKANKIKADY	KIF21B	696	O75037
QSKYHYKEEAEIICD	NANP	36	Q8TBE9
KYEEAISCHKKAAAY	NRBF2	26	Q96F24
HEKDGKAYCRKDYFD	PXN	456	P49023
DAKHKYLIALYTKDE	IRS2	106	Q9Y4H2
EAYIGADIKDKLKCY	CDC16	531	Q13042
ADIKDKLKCYDFDVH	CDC16	536	Q13042
EFCYEIKHGDLAKKS	DOC2B	336	Q14184
YKLCDLHKECDNYTE	DOCK1	1221	Q14185
IHDEEIYCKSCYGKK	CSRP2	51	Q16527
ALLVYCVKHYKGDEK	CHD6	1136	Q8TD26
HLKYDKFDDLCGYLE	CCDC191	131	Q8NCU4
VCDEHKEFKDVKLFY	DEPTOR	101	Q8TB45
KADYEKHKVYACEVT	IGKC	76	P01834
ECAHYFLEVKDKDIK	FRY	296	Q5TBA9
DCHKDEKGTIYDYEA	GPX5	31	O75715
KALDYESCEHYELKV	CDH15	326	P55291
DEGDEVKFKSYCLKH	JADE3	351	Q92613
CIIHYAGKVDYKADE	MYH10	576	P35580
KDYHTLKVYECELEA	FER1L5	1406	A0AVI2
ILKEEKDLRYCTKHY	GLRA1	216	P23415
KKTQYEEHIYRCEDE	SIN3A	601	Q96ST3
FDKLLKHYEAKPDCE	RASGRF1	356	Q13972
YYDEAQKIKEKHREE	SOX30	386	O94993
DEKKENYHKHACREY	TLK2	501	Q86UE8
YAKAEALCKEYGETK	BROX	281	Q5VW32
ECYHKLDSLTYKIDE	CLCC1	66	Q96S66
HKSVLDSFLKYDCKD	SPG11	826	Q96JI7
KCTEYLDRAEKLKEY	VPS4B	61	O75351
HKKIHTREYSYKCEE	ZNF92	191	Q03936
HDAELEKRKEICKFY	ZC3H6	296	P61129
DFKYIEKCSDVKHLE	SPAG1	26	Q07617
DKNYKDALSKYSECL	SPAG1	636	Q07617
KVYGFHKDYIECAEK	SERPINB7	106	O75635
HKDYIECAEKLYDAK	SERPINB7	111	O75635
DKTYECKECKKIFYH	ZNF25	171	P17030
CEYHGKNYKILEEFK	VWC2L	116	B2RUY7
EHKYIHTGEKLYKCE	ZNF117	266	Q03924
YCDICHLFDKDKKQY	RCHY1	86	Q96PM5
DAYHKKCDQKKKDYE	UBTF	341	P17480
AKDVDEYKLKDHYLE	PSD3	961	Q9NYI0
EVKYDDLYHCLVSKD	VPS13D	4301	Q5THJ4
KRIHTREKAYKCDEY	ZNF257	391	Q9Y2Q1
YEAIKKLDQCKDHTY	NEB	726	P20929
ASDCKYKEAYEKAKG	NEB	1571	P20929
EIASDYKYKLDHEKQ	NEB	4001	P20929