Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncatalytic activity, acting on RNA

RARS1 ZCWPW2 RPP40 SLFN14 THUMPD2 DICER1 DDX6 IARS2 SUPV3L1 MARF1 DDX53 PAN3 FDXACB1 MOV10

1.07e-0541716614GO:0140098
HumanPhenoPyelonephritis

BNC2 ALG9 ALG5 PKD1 MED12

1.64e-0621525HP:0012330
HumanPhenoIntellectual disability, mild

MASP1 ATP6AP1 ERCC6 RARS1 SPEG BRWD3 ACOX2 NSDHL TH BMPR1A VPS13D KLF13 GLRA2 MED12

1.05e-053655214HP:0001256
DomainZnf_C2H2-like

ZNF132 BNC2 ZNF143 SCRT1 ZNF154 ZNF596 KLF14 ZNF267 ZNF322 ZFPM1 ZNF285 KLF2 ZNF430 KLF16 ZNF28 KLF13 ZNF684 ZNF592 RBAK ZNF76 ZNF518B ZNF649 ZNF107 ZNF439 ZNF709 ZNF614 RNF138

2.00e-0979616627IPR015880
Domainzf-C2H2

ZNF132 BNC2 ZNF143 SCRT1 ZNF154 ZNF596 KLF14 ZNF267 ZNF322 ZFPM1 ZNF285 KLF2 ZNF430 KLF16 ZNF28 KLF13 ZNF684 ZNF592 RBAK ZNF76 ZNF649 ZNF107 ZNF439 ZNF709 ZNF614

2.47e-0969316625PF00096
DomainZnf_C2H2

ZNF132 BNC2 ZNF143 SCRT1 ZNF154 ZNF596 KLF14 ZNF267 ZNF322 ZFPM1 ZNF285 KLF2 ZNF430 KLF16 ZNF28 KLF13 ZNF684 ZNF592 RBAK ZNF76 ZNF518B ZNF649 ZNF107 ZNF439 ZNF709 ZNF614 RNF138

2.54e-0980516627IPR007087
DomainZnF_C2H2

ZNF132 BNC2 ZNF143 SCRT1 ZNF154 ZNF596 KLF14 ZNF267 ZNF322 ZFPM1 ZNF285 KLF2 ZNF430 KLF16 ZNF28 KLF13 ZNF684 ZNF592 RBAK ZNF76 ZNF518B ZNF649 ZNF107 ZNF439 ZNF709 ZNF614 RNF138

2.76e-0980816627SM00355
DomainZINC_FINGER_C2H2_2

ZNF132 BNC2 ZNF143 SCRT1 ZNF154 ZNF596 KLF14 ZNF267 ZNF322 ZFPM1 ZNF285 KLF2 ZNF430 KLF16 ZNF28 KLF13 ZNF684 ZNF592 RBAK ZNF76 ZNF518B ZNF649 ZNF107 ZNF439 ZNF709 ZNF614

5.19e-0977516626PS50157
DomainZINC_FINGER_C2H2_1

ZNF132 BNC2 ZNF143 SCRT1 ZNF154 ZNF596 KLF14 ZNF267 ZNF322 ZFPM1 ZNF285 KLF2 ZNF430 KLF16 ZNF28 KLF13 ZNF684 ZNF592 RBAK ZNF76 ZNF518B ZNF649 ZNF107 ZNF439 ZNF709 ZNF614

5.47e-0977716626PS00028
DomainZnf_C2H2/integrase_DNA-bd

ZNF132 ZNF143 SCRT1 ZNF154 ZNF596 KLF14 ZNF267 ZNF322 ZFPM1 ZNF285 KLF2 ZNF430 KLF16 ZNF28 KLF13 ZNF684 RBAK ZNF76 ZNF518B ZNF649 ZNF107 ZNF439 ZNF709 ZNF614

1.21e-0869416624IPR013087
Domain-

ZNF132 ZNF143 SCRT1 ZNF154 ZNF596 ZNF267 ZNF322 ZFPM1 ZNF285 KLF2 ZNF430 KLF16 ZNF28 KLF13 ZNF684 RBAK ZNF76 ZNF649 ZNF107 ZNF439 ZNF709 ZNF614

1.62e-07679166223.30.160.60
DomainKRAB

ZNF132 ZNF154 ZNF596 ZNF267 ZNF285 ZNF430 ZNF28 ZNF684 RBAK ZNF649 ZNF439 ZNF709 ZNF614

1.96e-0535816613PS50805
DomainKRAB

ZNF132 ZNF154 ZNF596 ZNF267 ZNF285 ZNF430 ZNF28 ZNF684 RBAK ZNF649 ZNF439 ZNF709 ZNF614

1.96e-0535816613PF01352
DomainKRAB

ZNF132 ZNF154 ZNF596 ZNF267 ZNF285 ZNF430 ZNF28 ZNF684 RBAK ZNF649 ZNF439 ZNF709 ZNF614

2.68e-0536916613SM00349
DomainKRAB

ZNF132 ZNF154 ZNF596 ZNF267 ZNF285 ZNF430 ZNF28 ZNF684 RBAK ZNF649 ZNF439 ZNF709 ZNF614

2.76e-0537016613IPR001909
DomainHECW_N

HECW1 HECW2

7.85e-0521662IPR032348
DomainHECW_N

HECW1 HECW2

7.85e-0521662PF16562
DomainHECT

HECW1 HUWE1 HECW2 HERC4

9.00e-05271664PF00632
DomainHECTc

HECW1 HUWE1 HECW2 HERC4

9.00e-05271664SM00119
DomainHECT_dom

HECW1 HUWE1 HECW2 HERC4

9.00e-05271664IPR000569
DomainHECT

HECW1 HUWE1 HECW2 HERC4

9.00e-05271664PS50237
DomainCUB

MASP1 DCBLD1 CSMD2 CSMD3

9.34e-04491664PF00431
Pubmed

Polycystic Kidney Disease, Autosomal Dominant

ALG9 ALG5 PKD1

3.75e-067167320301424
Pubmed

A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

DUSP5 ADARB2 MYOF BMPR1A LDB3 INA SGPL1 SUPV3L1 RASSF4 HERC4 ACSL5

5.85e-064151671116385451
Pubmed

Mammalian SP/KLF transcription factors: bring in the family.

KLF14 KLF2 KLF16 KLF13

6.00e-0625167415820306
Pubmed

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

HECW1 HUWE1 HECW2 HERC4

7.06e-0626167426949039
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

FKBP10 TMEM67 ATP6AP1 FKBP9 DCBLD1 MYOF KLF16 BMPR1A TK1 SGPL1 ALG9 DPY19L4 TMEM131L TMED9 ITM2C ALG6 TOR1AIP1 DCAF12

2.07e-0512011671835696571
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

PLK2 ZNF143 ATP6AP1 RARS1 ORC3 ZNF322 NSDHL ZNF28 SGPL1 ALG9 DHCR24 ALG5 RBAK TMED9 TBC1D23 HERC4 MED12 ACSL5

2.12e-0512031671829180619
Pubmed

The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor.

CYLD TRAIP

2.29e-052167214676304
Pubmed

ZNF76 and ZNF143 are two human homologs of the transcriptional activator Staf.

ZNF143 ZNF76

2.29e-05216729705341
Pubmed

MOV10 binding circ-DICER1 regulates the angiogenesis of glioma via miR-103a-3p/miR-382-5p mediated ZIC4 expression change.

DICER1 MOV10

2.29e-052167230621721
Pubmed

Stromal CCL5 Promotes Breast Cancer Progression by Interacting with CCR3 in Tumor Cells.

CCL5 CCR3

2.29e-052167233671956
Pubmed

Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes.

KLF13 CCL5

2.29e-052167217074812
Pubmed

Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5.

CERK CCL5

2.29e-052167229724781
Pubmed

Transcriptional regulation of the mouse cytosolic chaperonin subunit gene Ccta/t-complex polypeptide 1 by selenocysteine tRNA gene transcription activating factor family zinc finger proteins.

ZNF143 ZNF76

2.29e-052167210893243
Pubmed

A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic.

ALG5 ALG6

2.29e-052167210359825
Pubmed

Single nucleotide polymorphisms in the gene encoding Krüppel-like factor 7 are associated with type 2 diabetes.

KLF2 KLF16 KLF13

2.32e-0512167315937668
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

HECW1 ARHGAP39 MYOF VPS13D LDB3 ADAMTS9 SGPL1 ZNF518B MED12 MOV10 DCAF12

2.88e-054931671115368895
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

CERK CAND1 DICER1 SMG7 ZNF592 HECW2 DHCR24 TMEM131L LHFPL2 ESPL1 HERC4

5.44e-055291671114621295
Pubmed

Human transcription factor protein interaction networks.

CYLD ZNF143 RARS1 USP9X WDR5 NOSIP KLF16 SMG7 ZNF592 ACTR6 SLC25A13 MARF1 TMED9 PPIL2 PAN3 ZNF107 ZNF709 IMMT MOV10

6.12e-0514291671935140242
Pubmed

Genomic characterization of pediatric T-cell acute lymphoblastic leukemia reveals novel recurrent driver mutations.

USP9X MED12

6.85e-053167227602765
Pubmed

Cylindromatosis lysine 63 deubiquitinase (CYLD) suppress TLR3-mediated CCL5 expression in human renal proximal tubular epithelial cells.

CYLD CCL5

6.85e-053167239259342
Pubmed

Identification of two new members of the CSMD gene family.

CSMD2 CSMD3

6.85e-053167212906867
Pubmed

Tumor-derived chemokine CCL5 enhances TGF-β-mediated killing of CD8(+) T cells in colon cancer by T-regulatory cells.

CCL5 CCR3

6.85e-053167222282655
Pubmed

miRNA-130a targets ATG2B and DICER1 to inhibit autophagy and trigger killing of chronic lymphocytic leukemia cells.

ATG2B DICER1

6.85e-053167222350415
Pubmed

Differential activation of CC chemokine receptors by AOP-RANTES.

CCL5 CCR3

6.85e-053167210713092
Pubmed

A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes.

KLF13 CCL5

6.85e-053167212093895
Pubmed

Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution.

KLF14 KLF16

6.85e-053167217480121
Pubmed

CHCHD10 mutations promote loss of mitochondrial cristae junctions with impaired mitochondrial genome maintenance and inhibition of apoptosis.

CHCHD10 IMMT

6.85e-053167226666268
Pubmed

Fbw7γ-mediated degradation of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes.

KLF13 CCL5

6.85e-053167222797700
Pubmed

Astrocytic miR-324-5p is essential for synaptic formation by suppressing the secretion of CCL5 from astrocytes.

DICER1 CCL5

6.85e-053167230760705
Pubmed

Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter.

KLF16 KLF13

6.85e-053167212036432
Pubmed

Metabotropic glutamate receptors 1 and 5 differentially regulate bulbar dopaminergic cell function.

GRM5 TH

6.85e-053167220692242
Pubmed

Germline mutations of DICER1 in Chinese women with BRCA1/BRCA2-negative familial breast cancer.

DICER1 BRCA2

6.85e-053167225526195
Pubmed

Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.

ZNF132 ZNF143 ZNF154

7.04e-051716737557990
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

MASP1 CHCHD10 CAND1 USP9X DICER1 DDX6 NSDHL NOSIP KLF16 SMG7 SGPL1 ALG9 SLC25A13 TMEM131L TMED9 PPIL2 ALG6 MED12

7.51e-0513271671832694731
Pubmed

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.

RPP40 USP9X DDX6 SMG7 SUPV3L1 ALG5 PPIL2 ALG6 MED12 WIPI2

7.85e-054571671032968282
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

WDR5 DICER1 DDX6 NSDHL TMED9 PAN3 MED12 SLC25A31 MOV10 ACSL5

8.59e-054621671031138677
Pubmed

FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.

FKBP10 ATP6AP1 NSDHL SGPL1 ALG9 SLC25A13 ALG5 TMEM131L SMPD2 TOR1AIP1

9.55e-054681671031056421
Pubmed

Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease.

SGPL1 SUPV3L1 RASSF4

9.96e-0519167317373700
Pubmed

Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.

HIP1 CAND1 SLC25A13 VCAN IMMT

1.08e-0497167522360420
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

HIP1 CAND1 ATP6AP1 ERCC6 RARS1 ORC3 RPP40 ARHGAP39 DICER1 DDX6 MYOF ZNF592 SGPL1 SLC25A13 DHCR24 TMED9 IMMT MED12 MOV10

1.12e-0414971671931527615
Pubmed

Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.

HECW1 HECW2 CNOT4

1.36e-0421167337005481
Pubmed

Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS.

CCL5 CCR3

1.37e-044167210415069
Pubmed

CHCHD10-regulated OPA1-mitofilin complex mediates TDP-43-induced mitochondrial phenotypes associated with frontotemporal dementia.

CHCHD10 IMMT

1.37e-044167232369233
Pubmed

ATP release into ADPKD cysts via pannexin-1/P2X7 channels decreases ENaC activity.

PKD1 SCNN1A

1.37e-044167230952430
Pubmed

Host Cellular RNA Helicases Regulate SARS-CoV-2 Infection.

DDX6 MOV10

1.37e-044167235107372
Pubmed

FMRP and MOV10 regulate Dicer1 expression and dendrite development.

DICER1 MOV10

1.37e-044167234847178
Pubmed

Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo.

TH CDNF

1.37e-044167217611540
Pubmed

A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element.

KLF2 KLF13

1.37e-044167216023392
Pubmed

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival.

USP9X HUWE1

1.37e-044167220023629
Pubmed

CCR5, RANTES and SDF-1 polymorphisms and mother-to-child HIV-1 transmission.

KLF13 CCL5

1.37e-044167220518834
Pubmed

Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase.

CCL5 SMPD2

1.37e-044167221335555
Pubmed

Nonsense-mediated decay factor SMG7 sensitizes cells to TNFα-induced apoptosis via CYLD tumor suppressor and the noncoding oncogene Pvt1.

CYLD SMG7

1.37e-044167232602581
Pubmed

Biosynthesis and expression of a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats-15: a novel versican-cleaving proteoglycanase.

ADAMTS9 VCAN

1.37e-044167224220035
Pubmed

Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1/USP9X interaction.

USP9X HUWE1

1.37e-044167221907705
Pubmed

Distinct but overlapping epitopes for the interaction of a CC-chemokine with CCR1, CCR3 and CCR5.

CCL5 CCR3

1.37e-04416729289016
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

CYLD PLK2 CAND1 USP9X ANKS1B HUWE1 DSCAML1 BRWD3 ADAMTS9 ZNF592 SUPV3L1 NABP2 PKD1 ZNF76 TBC1D23 ZNF439 IMMT

1.62e-0412851671735914814
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

HUWE1 LDAH DDX6 NSDHL NOSIP MEMO1 IARS2 TK1 SLC25A13 ALG5 TBC1D23 MOV10

1.63e-047041671229955894
Pubmed

DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization.

CAND1 RARS1 USP9X HUWE1 DICER1 IMMT

2.10e-04175167625756610
Pubmed

Phenotypic annotation of the mouse X chromosome.

ATP6AP1 USP9X HUWE1 BRWD3

2.16e-0461167420548051
Pubmed

Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils.

CCL5 CCR3

2.27e-045167211449371
Pubmed

CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation.

MOV10 DCAF12

2.27e-045167234065512
Pubmed

Cloning, expression, and characterization of the human eosinophil eotaxin receptor.

CCL5 CCR3

2.27e-04516728642344
Pubmed

NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1.

HECW1 HECW2

2.27e-045167214684739
Pubmed

RANTES-induced chemokine cascade in dendritic cells.

CCL5 CCR3

2.27e-045167211466387
Pubmed

Analysis of KLF transcription factor family gene variants in type 2 diabetes.

KLF2 KLF16

2.27e-045167217688680
Pubmed

MicroRNAs regulate renal tubule maturation through modulation of Pkd1.

DICER1 PKD1

2.27e-045167223138483
Pubmed

mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux.

ATG2B HUWE1 WIPI2

2.31e-0425167330340022
Pubmed

TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.

CAND1 RARS1 USP9X IARS2 SLC25A13 IMMT

2.37e-04179167636261009
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

MROH9 CACNA1F CHCHD10 RARS1 HUWE1 CSMD2 DSCAML1 ADAMTS9 ZNF592 HECW2 PKD1 RBM43

2.45e-047361671229676528
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF267 ZNF430 ZNF684 ZNF649 ZNF107 ZNF614

2.52e-04181167637372979
Pubmed

Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.

FKBP10 ATP6AP1 RARS1 FKBP9 THUMPD2 DDX6 NSDHL MYOF IARS2 INA SLC25A13 TMED9 IMMT

2.78e-048591671331536960
Pubmed

Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

CDIP1 CAND1 ORC3 ALG9 DPY19L4 TMEM131L ITM2C ZNF649 WIPI2 SLC25A31 MOV10 ZMYND12

2.91e-047501671211230166
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

ORC3 USP9X HUWE1 DICER1 DDX6 ZNF592 ACTR6 ESPL1 MOV10

2.95e-04440167934244565
Pubmed

Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP-2, with outcome of HCV infection.

CCL5 CCR3

3.39e-046167214647058
Pubmed

Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest.

CSMD2 ZNF592

3.39e-046167220360844
Pubmed

USP9X destabilizes pVHL and promotes cell proliferation.

USP9X HUWE1

3.39e-046167227517496
Pubmed

Investigating the role of adrenal cortex in organization and differentiation of the adrenal medulla in mice.

DICER1 TH

3.39e-046167222580128
Pubmed

Proteolytic cleavage of versican during cardiac cushion morphogenesis.

ADAMTS9 VCAN

3.39e-046167216691565
Pubmed

MicroRNA silencing through RISC recruitment of eIF6.

DICER1 MOV10

3.39e-046167217507929
Pubmed

Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family.

FKBP10 FKBP9

3.39e-046167212036304
Pubmed

In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression.

CCL5 CCR3

3.39e-04616729359702
Pubmed

A MicroRNA feedback circuit in midbrain dopamine neurons.

DICER1 TH

3.39e-046167217761882
Pubmed

Quantitative interactome proteomics identifies a proteostasis network for GABAA receptors.

CAND1 USP9X HUWE1 SLC25A13 IMMT

3.54e-04125167536030824
Pubmed

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.

ATP6AP1 ERCC6 RARS1 HUWE1 DSCAML1 BMPR1A CNOT4 MOV10

3.57e-04358167832460013
Pubmed

Mechanisms of MCL-1 Protein Stability Induced by MCL-1 Antagonists in B-Cell Malignancies.

USP9X HUWE1

4.74e-047167236346691
Pubmed

The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican.

ADAMTS9 VCAN

4.74e-047167215599946
Pubmed

Mov10 and APOBEC3G localization to processing bodies is not required for virion incorporation and antiviral activity.

DDX6 MOV10

4.74e-047167223926332
Pubmed

Elongator and codon bias regulate protein levels in mammalian peripheral neurons.

BRCA2 VCAN

4.74e-047167229497044
Pubmed

DNA repair protein Rad18 restricts LINE-1 mobility.

DDX6 MOV10

4.74e-047167230367120
Pubmed

Elevated lung cancer risk is associated with deficiencies in cell cycle checkpoints: genotype and phenotype analyses from a case-control study.

ERCC6 BRCA2

4.74e-047167219626602
Pubmed

Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD.

CYLD CCL5

4.74e-047167227279133
Pubmed

Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults.

ADAMTS9 VCAN

4.74e-047167223354118
Pubmed

Defining the membrane proteome of NK cells.

CAND1 RARS1 USP9X HUWE1 DDX6 ALG9 DHCR24 ALG5 OASL MARF1 PARP9 ALG6 IMMT MED12 ACSL5

5.39e-0411681671519946888
Pubmed

LINKIN, a new transmembrane protein necessary for cell adhesion.

FKBP10 ATP6AP1 RARS1 DDX6 SLC25A13 DHCR24 ALG5 IMMT RNF138

5.52e-04480167925437307
Pubmed

Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.

CAND1 HECW1 USP9X HUWE1

5.82e-0479167427325702
Pubmed

TRIM24 is an insulin-responsive regulator of P-bodies.

DDX6 SMG7 IMMT CNOT4

6.10e-0480167435803934
Pubmed

A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A.

KLF16 KLF13

6.30e-048167211438660
Pubmed

The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel.

HECW1 SCNN1A

6.30e-048167211244092
Pubmed

Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation.

ADAMTS9 VCAN

6.30e-048167221041365
Pubmed

The secreted metalloprotease ADAMTS20 is required for melanoblast survival.

ADAMTS9 VCAN

6.30e-048167218454205
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF132 BNC2 ZNF143 SCRT1 ZNF154 ZNF596 KLF14 ZNF267 ZNF322 ZFPM1 ZNF285 KLF2 ZNF430 KLF16 ZNF28 KLF13 ZNF684 ZNF592 RBAK ZNF76 ZNF518B ZNF649 ZNF107 ZNF439 ZNF709 ZNF614

1.31e-127181212628
GeneFamilyZinc fingers C2H2-type|Kruppel like factors

KLF14 KLF2 KLF16 KLF13

5.43e-06181214624
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

MASP1 CSMD2 CSMD3 VCAN

5.73e-045712141179
GeneFamilyBRICHOS domain containing

GKN2 ITM2C

1.55e-0391212457
GeneFamilyX-linked mental retardation|RNA helicases

DICER1 SUPV3L1

2.35e-031112121168
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Pcdh11x_(Neuron.Gad1Gad2.Synpr-Pcdh11x)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

MAGEB16 SLFN14 TECTA CCL5 SLC25A31 ZMYND12

9.15e-0859167650432c7b52fd197e8856ba0296c34cf66a2faaf5
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Pcdh11x_(Neuron.Gad1Gad2.Synpr-Pcdh11x)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

MAGEB16 SLFN14 TECTA CCL5 SLC25A31 ZMYND12

9.15e-08591676439a9d56eeecccd70a4defb430e228329655cb80
ToppCellfacs-Brain_Myeloid-Cortex_-18m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIP1 MSRB1 TTLL9 DUSP5 MYOF PLA2G2D SCNN1A

2.09e-0615616772ba838bc864c2c1767bcab7bb4d790af96b91387
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

GALR1 GKN2 LINGO2 CFAP65 INA CELF3 SCNN1A

6.68e-061861677c7983281a290201567b398e9ea6baddb96c692bb
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MROH9 DPP10 HECW1 CSMD2 GRM5 CSMD3 VCAN

1.04e-05199167719a97e27a4758e794ce7246d295e112b47931a48
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MROH9 DPP10 HECW1 CSMD2 GRM5 CSMD3 VCAN

1.04e-051991677e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MROH9 DPP10 HECW1 CSMD2 GRM5 CSMD3 VCAN

1.04e-051991677333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCellMacroglial-Polydendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

MROH9 HECW1 CSMD2 GRM5 CSMD3 ADARB2 VCAN

1.07e-052001677961858738ce35db8760c8c2e136f8369bc444ccf
ToppCellMacroglial-Polydendrocytes-PDGFRA-|Macroglial / cells hierarchy compared to all cells using T-Statistic

MROH9 HECW1 CSMD2 GRM5 CSMD3 ADARB2 VCAN

1.07e-052001677f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCellMacroglial-Polydendrocytes-PDGFRA--|Macroglial / cells hierarchy compared to all cells using T-Statistic

MROH9 HECW1 CSMD2 GRM5 CSMD3 ADARB2 VCAN

1.07e-052001677cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCellMacroglial-Polydendrocytes-PDGFRA|Macroglial / cells hierarchy compared to all cells using T-Statistic

MROH9 HECW1 CSMD2 GRM5 CSMD3 ADARB2 VCAN

1.07e-052001677c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCellMacroglial-Polydendrocytes-PDGFRA---|Macroglial / cells hierarchy compared to all cells using T-Statistic

MROH9 HECW1 CSMD2 GRM5 CSMD3 ADARB2 VCAN

1.07e-0520016774fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCellMacroglial-Polydendrocytes-PDGFRA----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

MROH9 HECW1 CSMD2 GRM5 CSMD3 ADARB2 VCAN

1.07e-052001677310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5|368C / Donor, Lineage, Cell class and subclass (all cells)

ERCC6 WDR5B ZNF684 CCL5 ZNF649 ZNF107

2.94e-051581676390b9c455ed15a6804613eecfd2776949dfba146
ToppCellP15-Epithelial-epithelial_progenitor_cell-epi_progenitor|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CDIP1 CHCHD10 VEPH1 FAM83H MYOF SCNN1A

3.05e-051591676a4bfd59c53237964fc24a24de5c1925fdd01db99
ToppCellnormal_Lung-Myeloid_cells-Undetermined|Myeloid_cells / Location, Cell class and cell subclass

ELAPOR2 RDH12 ARHGAP39 PLA2G2D TBC1D23 ZMYND12

3.27e-051611676283012858e575c70d09950de53da041509f59bfa
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ELAPOR2 DPP10 HECW1 ANKS1B TECTA CSMD3

3.39e-051621676bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellfacs-Heart-LV-3m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHCHD10 MSRB1 NTMT2 CSMD3 LDB3 SCNN1A

3.75e-05165167684eca6a0f5e996b6955ae79fa102af239098fe8f
ToppCellfacs-Heart-LV-3m-Mesenchymal-atrial_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHCHD10 MSRB1 NTMT2 CSMD3 LDB3 SCNN1A

3.75e-051651676af59a095ecc6758abc13d763c00e44447c488167
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Hematologic-red_blood_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRAIP MAGEB16 SLFN14 TECTA MEMO1 DCAF12

3.75e-05165167662dd54dfbec7f43a41546a1fec719545c2608a36
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BNC2 DPP10 HECW1 CSMD2 CSMD3 AFM

4.02e-0516716763edb0570e583bb527165bcd8a4c25a042054043b
ToppCellLPS-IL1RA-Epithelial_alveolar-Mes-Like-Differentiating_AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DPP10 BRCA2 TK1 HECW2 ABCC12

4.33e-051031675eb9f008b5fb8a01df8ea4faf6e6aebc1a9db9bd3
ToppCellBAL-Severe-Epithelial-Epithelial-undefined_Epi|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ARHGAP42 DPP10 MUC5B SLFN14 VN1R1 AFM

5.73e-05178167649a2271718637522f74334068d252963ee13b1ce
ToppCellBAL-Severe-Epithelial-Epithelial-undefined_Epi-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ARHGAP42 DPP10 MUC5B SLFN14 VN1R1 AFM

5.73e-0517816769a3ef66814dfca7b37024e7f79e86ea8c72ae10f
ToppCellBAL-Severe-Epithelial-Epithelial-undefined_Epi-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ARHGAP42 DPP10 MUC5B SLFN14 VN1R1 AFM

5.73e-051781676b413a634283550fa224db7d0d05956e3f64694a1
ToppCellBAL-Severe-Epithelial-Epithelial-undefined_Epi|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

ARHGAP42 DPP10 MUC5B SLFN14 VN1R1 AFM

5.73e-05178167619b5432aa1d7f616d58a106543c18cf2d7ca840c
ToppCellT_cells-ISG-high_CD4+_T_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

RFX8 BRCA2 OASL PARP9 RBM43 MOV10

5.91e-051791676af35ef8a7768cee0c2af0590e5bec35cee6a4714
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1F VEPH1 DSCAML1 MYOF SH2D4A SCNN1A

6.28e-051811676b45b11428d13950369347e051d4d517efb2bd4fd
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-OPC|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGAP42 MROH9 HIP1 GALR1 ADARB2 VCAN

6.48e-0518216768a8b08ac4bb3cba3541dbe234e088703842285b9
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-OPC|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGAP42 MROH9 HIP1 GALR1 ADARB2 VCAN

6.48e-0518216763cc61f5f7ad4a81eba3daf65e122880b5af3adc0
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGAP42 MROH9 HIP1 GALR1 ADARB2 VCAN

6.48e-051821676e36766309c4d96a90d213ce37d3acef1029a3fdc
ToppCellnormal_Lung-Myeloid_cells-CD207+CD1a+_LCs|Myeloid_cells / Location, Cell class and cell subclass

TMEM67 HIP1 GPR82 SMPD2 ZNF439 ESPL1

6.48e-0518216768dd79fef8f8463ad3194f9cc07c6cacf2c886304
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGAP42 MROH9 HIP1 GALR1 ADARB2 VCAN

6.48e-0518216765d909e4b5f662905bf1be9c686bbddc3e87d2be9
ToppCellLV-07._Pericyte|World / Chamber and Cluster_Paper

ARHGAP42 HIP1 DCBLD1 DSCAML1 VPS13D ADAMTS9

6.68e-051831676273db6a3b00a93ca852498471187b642b5368185
ToppCell10x3'2.3-week_14-16-Lymphocytic_NK-T_NK-mature_NK|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

BNC2 TTLL9 LINGO2 FAM83H BMPR1A CCL5

6.68e-0518316768746e6ecc6bf9e194cc9cdf9b07da63f0fcf8b5f
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1F HECW1 MUC5B CSMD3 DSCAML1 LDB3

6.88e-0518416762cbed6462fea2622871bb7e49b0df3d984239281
ToppCellCOPD-Stromal-Pericyte|COPD / Disease state, Lineage and Cell class

ARHGAP42 MASP1 ZCWPW2 ADARB2 ADAMTS9 ITM2C

6.88e-051841676a56264a22dfc2d3672b20134ab7c3c7c23da5ae1
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1F HECW1 MUC5B CSMD3 DSCAML1 LDB3

6.88e-0518416762b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1F HECW1 MUC5B CSMD3 DSCAML1 LDB3

6.88e-051841676ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellCOVID-19-kidney-PCT-S1/S2|kidney / Disease (COVID-19 only), tissue and cell type

ARHGAP42 BNC2 HECW1 ANKS1B AFM RASSF4

6.88e-051841676dc71f22583fc54b89b242cbb602f4bbe86f576ec
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGAP42 MROH9 HIP1 GALR1 ADARB2 VCAN

7.09e-0518516762e1766f1a972fecd670daaaf7eb2d3a404f121e7
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGAP42 MROH9 HIP1 GALR1 ADARB2 VCAN

7.09e-0518516767aaa8335b40927e3e8fdcede807cd521fc213a0d
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-OPC|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGAP42 MROH9 HIP1 GALR1 ADARB2 VCAN

7.09e-051851676fba2dc46cd98ab9c78e788959c2121aa10d148b2
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGAP42 MROH9 HIP1 GALR1 ADARB2 VCAN

7.09e-051851676efc5d564f8793c751ba640aef60f761e4b081d3f
ToppCellLAM-Lymphoid-B-cell-2|Lymphoid / Condition, Lineage and Cell class

DUSP5 KLF13 PLA2G2D ALG5 TMED9 ITM2C

7.30e-051861676bcfe0bf2f7f745146b74496a4fcfccd869ad7c6f
ToppCellCOPD-Stromal-Pericyte|World / Disease state, Lineage and Cell class

ARHGAP42 MASP1 ZCWPW2 ADARB2 ADAMTS9 ITM2C

7.30e-0518616768adfd2d1fda4e8aecc95192ea627bf7ed5214b8d
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Pulmonary_neuroendocrine|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

DPP10 GKN2 INA CELF3 SCNN1A ESPL1

7.30e-051861676fcabebdfbf1b1dbb35ce2b3c53a60d2b1aed8e6c
ToppCellnormal_Lung-Myeloid_cells-pDCs|Myeloid_cells / Location, Cell class and cell subclass

TMEM67 DSCAML1 BRWD3 RAVER2 ITM2C ZNF614

7.52e-051871676a3592f056e1c2f82ba325fea2ecc4dd6c6347c81
ToppCellnormal_Lung-Myeloid_cells-pDCs|normal_Lung / Location, Cell class and cell subclass

TMEM67 DSCAML1 BRWD3 RAVER2 ITM2C ZNF614

7.52e-051871676d36751372fd40a46441f07735c9c3c5dcb503f24
ToppCellfacs-Heart-LV-3m-Mesenchymal-ventricular_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHCHD10 TRAIP LDB3 SLC25A13 FBXW5 LRP2BP

7.75e-05188167640ce7125fca6f6b6b5cc1637c87d43c29b08f4f1
ToppCellfacs-Heart-LV-3m-Mesenchymal-ventricular_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHCHD10 TRAIP LDB3 SLC25A13 FBXW5 LRP2BP

7.75e-051881676ba7f7ce034c0f42742bf2461f68f8d343ee593a5
ToppCell21-Trachea-Epithelial-Neuroendocrine|Trachea / Age, Tissue, Lineage and Cell class

DPP10 LINGO2 INA CELF3 SCNN1A ESPL1

7.75e-051881676e78d4f7a5d28c77503cb041ff585d13df4c88bd2
ToppCell368C-Epithelial_cells-Epithelial-E_(AT2)-|368C / Donor, Lineage, Cell class and subclass (all cells)

ELAPOR2 GKN2 VEPH1 FAM83H DHCR24 SCNN1A

7.98e-051891676926b5fa3064b501a57ba78583e8af33532add455
ToppCell368C-Epithelial_cells-Epithelial-E_(AT2)|368C / Donor, Lineage, Cell class and subclass (all cells)

ELAPOR2 GKN2 VEPH1 FAM83H DHCR24 SCNN1A

7.98e-0518916766f2322d017b74a1757c81d6e06f50ead8c3dd0cc
ToppCellPCW_13-14-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

GKN2 LINGO2 CFAP65 INA CELF3 SCNN1A

8.45e-05191167619832ddd559a353e1618fe853d79e3edfec6dcda
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

SFMBT1 FKBP10 MSRB1 ZCWPW2 DICER1 ALG6

8.45e-051911676cadb7a9de16f4bb21606de0e25cddd2d748c7f0b
ToppCellPCW_10-12-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

GKN2 LINGO2 CFAP65 INA CELF3 SCNN1A

8.70e-0519216764d3a1c267739b1479217144656986972fc86db43
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_basal-Dividing_Basal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

GKN2 VN1R1 FAM83H TK1 SCNN1A ESPL1

9.21e-051941676d790cfff3664e46fe2fd2f6b0c26896799927845
ToppCellIPF-Stromal-Pericyte|Stromal / Disease state, Lineage and Cell class

ARHGAP42 CHCHD10 HIP1 ADARB2 LDB3 ADAMTS9

9.21e-0519416763892b188f424ffb80f3c75a1b6709a21c1e1601d
ToppCellIPF-Stromal-Pericyte|World / Disease state, Lineage and Cell class

ARHGAP42 FKBP10 ZCWPW2 LDB3 ADAMTS9 ITM2C

9.21e-0519416761a41da29d5adaf766a84eff0003b959e4523f7f1
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

HECW1 ANKS1B LINGO2 GRM5 CSMD3 PKD1

9.74e-051961676676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell343B-Endothelial_cells-Endothelial-A_(Artery)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FKBP10 NOSIP MYOF BMPR1A ADAMTS9 FBXW5

1.00e-041971676ec92d60f802c9d4bdf9877bed5c0a91a5a5ed5d0
ToppCell343B-Endothelial_cells-Endothelial-A_(Artery)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FKBP10 NOSIP MYOF BMPR1A ADAMTS9 FBXW5

1.00e-0419716767bec9c1bc8851064eb229324493b47a31201c83c
ToppCell(1)_B_cell-(101)_plasma|(1)_B_cell / immune cells in Peripheral Blood (logTPM normalization)

DUSP5 TK1 ALG5 TMED9 ITM2C DCAF12

1.00e-041971676c86fcd779f30074bdf0b23d763fee5b7e4a6e4f5
ToppCell(1)_B_cell-(10)_B_cell-(101)_plasma|(10)_B_cell / immune cells in Peripheral Blood (logTPM normalization)

DUSP5 TK1 ALG5 TMED9 ITM2C DCAF12

1.00e-041971676c7af5510e2dd69b6a044244b22e62b82f474fdbd
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Hematologic-erythrocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GALR1 MAGEB16 SLFN14 MEMO1 DCAF12

1.01e-04123167589415e47db7352ba385895e2127e683db131dc03
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

CACNA1F VEPH1 DSCAML1 MYOF SH2D4A SCNN1A

1.03e-041981676b598ab958e31f1e98bd06dc0097b58ac3a3f90a3
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-6_mon-Neuronal|6_mon / Sample Type, Dataset, Time_group, and Cell type.

PLK2 SCRT1 TMEFF2 INA CELF3 GLRA2

1.03e-041981676076c862f2a723f0361749377561cae902068b1a0
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

CACNA1F VEPH1 DSCAML1 MYOF SH2D4A SCNN1A

1.06e-041991676d43c605a4ff221cf78d91678c15d2ad20f831c7f
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

CACNA1F VEPH1 DSCAML1 MYOF SH2D4A SCNN1A

1.06e-041991676a270630626df614f8605abddb7dee7c4d74f6149
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Radial_glial-RGCs_3|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

FKBP10 INTU MASP1 BRCA2 ADAMTS9 TK1

1.06e-04199167679d87e2b0adeff2d33c3b699afe7211fddc4f285
ToppCellSepsis-URO-Lymphocyte-T/NK-dn_T|URO / Disease, condition lineage and cell class

SFMBT1 IARS2 DPY19L4 SMPD2 RBM43 MOV10

1.09e-04200167604ea6381b93a5d8bbeda4d71c788d7fbac6d40bc
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

ANKS1B LINGO2 GRM5 CSMD3 HECW2 PKD1

1.09e-04200167648d801219bc771d6c7e151dc88ca4c179988de85
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Radial_glial-RGCs_3|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

FKBP10 INTU MASP1 VEPH1 ADAMTS9 VCAN

1.09e-04200167655a1df656545ff078b727d55e4d65d61ddb5c41f
ToppCelldroplet-Heart-HEART-1m-Hematologic-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THUMPD2 VPS13D SLC25A13 RBAK MOV10

1.17e-041271675983489a69d3b1f1fe21110a862ac1dba53e9d31c
Diseasereticulocyte count

ARHGAP42 BNC2 PLK2 FNTB USP9X SPPL3 FKBP9 KLF14 ZFPM1 SLFN14 KLF16 KLF13 SGPL1 PKD1 TMEM131L MED12 WIPI2 DCAF12

2.06e-05104516318EFO_0007986
Diseasecongenital disorder of glycosylation type I (implicated_via_orthology)

ALG9 ALG5 ALG6

7.17e-05151633DOID:0050570 (implicated_via_orthology)
Diseaseintestinal disease (is_implicated_in)

BMPR1A SLC10A2

9.07e-0531632DOID:5295 (is_implicated_in)
DiseaseIchthyoses

SGPL1 SUPV3L1

1.81e-0441632C0020757
Diseasereticulocyte measurement

ARHGAP42 BNC2 FNTB USP9X SPPL3 FKBP9 KLF14 ZFPM1 SLFN14 KLF16 KLF13 SGPL1 TMEM131L MED12 WIPI2 DCAF12

2.54e-04105316316EFO_0010700
Diseaseresponse to bronchodilator, response to corticosteroid

CSMD3 ZNF614

3.00e-0451632GO_0031960, GO_0097366
Diseaseadverse effect, response to xenobiotic stimulus

DPP10 ADARB2 TMEFF2 SCNN1A

3.22e-04591634EFO_0009658, GO_0009410
Diseasenon-melanoma skin carcinoma

BNC2 ZFPM1 CSMD2 GRM5 SLC10A2 BRCA2 CCR3

7.06e-042651637EFO_0009260
Diseasecutaneous squamous cell carcinoma

BNC2 ZNF143 BRCA2

7.99e-04331633EFO_1001927
Diseaserheumatoid arthritis, celiac disease

DDX6 SMG7 CCR3

7.99e-04331633EFO_0000685, EFO_0001060
DiseasePolycystic Kidney, Autosomal Dominant

ALG9 PKD1

1.06e-0391632C0085413
Diseasedisease free survival, type 1 diabetes mellitus

TH PPIL2

1.06e-0391632EFO_0000409, MONDO_0005147
DiseaseAnorectal Malformations

INTU TTLL9 MED12

1.51e-03411633C3495676
DiseaseCystic Kidney Diseases

TMEM67 ALG9

1.61e-03111632C1691228
DiseaseCraniofacial Abnormalities

BNC2 MASP1 ERCC6 FAM83H BMPR1A

1.79e-031561635C0376634
Diseaseintracranial aneurysm (is_implicated_in)

VCAN PKD1

1.93e-03121632DOID:10941 (is_implicated_in)
Diseaseevent free survival time, type 1 diabetes mellitus, autoantibody measurement

TH PPIL2

1.93e-03121632EFO_0000482, EFO_0004866, MONDO_0005147
DiseaseRS-10-hydroxywarfarin measurement

DSCAML1 ITM2C RBM43 WIPI2

2.17e-03981634EFO_0803330
Diseaseextrinsic allergic alveolitis (is_marker_for)

CCL5 CCR3

2.64e-03141632DOID:841 (is_marker_for)
Diseasehip circumference

SFMBT1 ELAPOR2 ZNF143 DPP10 KLF14 ANKS1B ADARB2

2.83e-033381637EFO_0005093
DiseaseFamilial thoracic aortic aneurysm and aortic dissection

VCAN PKD1 MED12

3.17e-03531633C4707243
Diseaseautosomal recessive polycystic kidney disease (implicated_via_orthology)

TMEM67 PKD1

3.46e-03161632DOID:0110861 (implicated_via_orthology)
Diseaseseasonal gut microbiome measurement

DPP10 LINGO2 ADARB2 MYOF

3.51e-031121634EFO_0007753
DiseaseDrug habituation

GRM5 CSMD3 ADARB2 SLC10A2

3.86e-031151634C0013170
DiseaseDrug abuse

GRM5 CSMD3 ADARB2 SLC10A2

3.86e-031151634C0013146
DiseasePrescription Drug Abuse

GRM5 CSMD3 ADARB2 SLC10A2

3.86e-031151634C4316881
DiseaseSubstance-Related Disorders

GRM5 CSMD3 ADARB2 SLC10A2

3.86e-031151634C0236969
DiseaseDrug Use Disorders

GRM5 CSMD3 ADARB2 SLC10A2

3.86e-031151634C0013222
DiseaseDrug Dependence

GRM5 CSMD3 ADARB2 SLC10A2

3.86e-031151634C1510472
DiseaseSubstance Dependence

GRM5 CSMD3 ADARB2 SLC10A2

3.86e-031151634C0038580
DiseaseSubstance Use Disorders

GRM5 CSMD3 ADARB2 SLC10A2

3.86e-031151634C0038586
DiseaseOrganic Mental Disorders, Substance-Induced

GRM5 CSMD3 ADARB2 SLC10A2

3.86e-031151634C0029231
DiseaseSubstance abuse problem

GRM5 CSMD3 ADARB2 SLC10A2

3.98e-031161634C0740858
Diseaseanorectal malformation

MUC5B CSMD2

4.88e-03191632MONDO_0019938
Diseasemean reticulocyte volume

INTU FNTB ZFPM1 KLF16 KLF13 TK1 SGPL1 ALG9 TMEM131L ITM2C ALG6

4.99e-0379916311EFO_0010701

Protein segments in the cluster

PeptideGeneStartEntry
GYSFTHIVPYCRSKK

ACTR6

151

Q9GZN1
AKKISQLGYSCFYIH

DDX6

351

P26196
QAAKVHCYYVTVKGF

ACOX2

541

Q99424
DKYTGLHKGCAFLTY

CELF3

41

Q5SZQ8
THTCPSCKAYIYTYK

CDIP1

191

Q9H305
GSDLKLGSSVTYYCH

CSMD2

1571

Q7Z408
NGSHYEYKTKVVFSC

CSMD3

2711

Q7Z407
EYKTKVVFSCDPGYH

CSMD3

2716

Q7Z407
CNYHLTYTCKKGTVA

VCAN

3281

P13611
LCYYLGATKDAATKI

CDNF

81

Q49AH0
CGKTFYDKGTLKIHY

BNC2

446

Q6ZN30
TAYHSLLCAYVAKFI

ALG6

76

Q9Y672
QYLKAFSSYQKHVCG

AFM

211

P43652
FSSYQKHVCGALLKF

AFM

216

P43652
TSKVAFKYCQKYGSD

ALG5

116

Q9Y673
YFYKAVCKKFGLHVS

ALG9

156

Q9H6U8
EHYLCSSSSYRKVFG

INA

6

Q16352
ECHKTYYTRHTGFKT

ARL14EP

16

Q8N8R7
LHFKKVYSLEAYSCA

EXOC1L

91

A0A1B0GW35
HLLLFGFGCSKYYEK

BRWD3

536

Q6RI45
SFLKHAITTYLFCTY

DICER1

1321

Q9UPY3
KYHLYSTILKFFSDC

DPP10

766

Q8N608
VTKYEGFDDKHYICL

ATG2B

1096

Q96BY7
YDLHGDCSYVLSKKC

MUC5B

441

Q9HC84
CFLVYSEVTGHSKGY

RAVER2

171

Q9HCJ3
VFLYLKHKCGSYEST

RBM43

226

Q6ZSC3
CKKHYYDGTIFHRSI

PPIL2

311

Q13356
GLLKTYNCYHEGKSF

RASSF4

26

Q9H2L5
YCEAKLGAHTYQSVK

ADARB2

696

Q9NS39
GVAISTYAKYCYHKL

ARHGAP39

841

Q9C0H5
TKGFNLFCKYIYHVL

PARP9

381

Q8IXQ6
KNCTAGAVYTYHEKK

NOSIP

6

Q9Y314
FAYITKDLKSNHHYC

ANKS1B

1146

Q7Z6G8
IVKYSNLYACSKGVH

ERCC6

626

P0DP91
IKICFKYYHGISGAL

HECW2

136

Q9P2P5
EKRYSRGFAYCHSKL

RDH12

191

Q96NR8
LFKGKFYTCTDEAKH

CACNA1F

1021

O60840
FPDCAKAYYKSSHLK

KLF16

131

Q9BXK1
AKEGICIAHSYKIYS

GRM5

236

P41594
TSCYEKIFYGHLLKK

GPR82

131

Q96P67
TTHCYGLFIKLGLTY

MAGEB16

176

A2A368
YCEKDYINLFSTKCH

LDB3

656

O75112
TKICFKYYHGVSGAL

HECW1

156

Q76N89
HASFYSADLVCKLYS

CFAP65

1511

Q6ZU64
HVGKIYSKCSSFLDY

METTL25

496

Q8N6Q8
KEHRKFYTIHCTGYL

ARNTL2

306

Q8WYA1
THKQSYYSIAKCVAA

CAND1

791

Q86VP6
AKSKYLIFTTGCLTY

FBXW5

346

Q969U6
QVACGYYHSLALSKA

HERC4

141

Q5GLZ8
YYHSLALSKASEVFC

HERC4

146

Q5GLZ8
FHSLEAYLAHKKYSC

ZFPM1

826

Q8IX07
LSTFIAHKKYYCSSH

ZFPM1

986

Q8IX07
GHYCLYSKSSFILIS

VEPH1

596

Q14D04
QKAIDYCGHYASAYK

LHFPL2

161

Q6ZUX7
NTFKLLSYASYCIEH

IMMT

686

Q16891
DETTAKHYYSKACRL

LRP2BP

316

Q9P2M1
FHSTALSFYFTCKKP

LINGO2

396

Q7L985
YDLYTSCSHLKNKFG

MED12

976

Q93074
LCYYHGVCFIAKTLS

MROH9

481

Q5TGP6
CYFTRSFYKHILGKS

HUWE1

4126

Q7Z6Z7
YHSVCRLCYFKKASG

TK1

181

P04183
SKGTKYFHFFNISLC

ELAPOR2

706

A8MWY0
GLTAYHDISLDKCYV

ITM2C

151

Q9NQX7
CSLAKYGIFSHTHIY

OASL

411

Q15646
GSSLFYKGYLICSHL

INTU

516

Q9ULD6
LYKAVSGFYISCKSF

SMPD2

241

O60906
KSSNFGYITSCYKAV

PAN3

496

Q58A45
DCSVLSKKGDYLKYH

FKBP9

381

O95302
HKKAYVVCTFVFGYL

GALR1

196

P47211
YKGTLDCFVKIYQHE

SLC25A31

261

Q9H0C2
ELKHCFYKGYVNTNS

ADAMTS9

146

Q9P2N4
SFYSHKLYAEACAIS

ESPL1

466

Q14674
TKLGDFVRYHYNCSL

FKBP10

396

Q96AY3
GSCSSTTIFDYKHGY

GKN2

56

Q86XP6
SHKQLYTYGVSKHCI

BRCA2

2536

P51587
YTYGVSKHCIKINSK

BRCA2

2541

P51587
CKLLSGFYHTGLYSE

CCR3

106

P51677
VYTHCYDSSGTKLFV

DCAF12

421

Q5T6F0
DALSTYRCITKHKYS

DSCAML1

191

Q8TD84
SEALKQCKYYHGLSS

CHCHD10

126

Q8WYQ3
YDFSGLKTFLSHHCY

CERK

311

Q8TCT0
SSHKYGLFQHICTAY

DHCR24

176

Q15392
YHENGSLYDFLKCAT

BMPR1A

311

P36894
DKLTYSKYGRFCHEV

DPY19L4

676

Q7Z388
SKYGRFCHEVKINYS

DPY19L4

681

Q7Z388
EYLGSCLLHKGYKSS

ACSL5

116

Q9ULC5
HIKEYFYTSGKCSNP

CCL5

46

P13501
YCTKHYNTGKFTCIE

GLRA2

231

P23416
HFAKQCRVSDYGYSK

MARF1

1131

Q9Y4F3
LYYALCFSLSKASAH

MASP1

6

P48740
KSRDFYHTCYCLSGL

FNTB

356

P49356
YAGCEKVYGKSSHLK

KLF13

171

Q9Y2Y9
GCTKAYYKSSHLKSH

KLF14

201

Q8TD94
HVEAECSKYSYKGLK

DDX53

311

Q86TM3
CIETSHYVAFVKYGK

CYLD

866

Q9NQC7
RASHYLKTEYSKFCP

DCBLD1

161

Q8N8Z6
YYCRTGKSFKGHVKE

FAM83H

216

Q6ZRV2
GYKCTGYRSQDKSFH

FDXACB1

171

Q9BRP7
CYYKLQVDFSSDHLG

SCNN1A

456

P37088
LYLGSAYHASKCEFL

DUSP5

186

Q16690
HCEEFCVYKGSLSSY

PKD1

2521

P98161
AAIFLGFYVAYKKCH

SLC10A2

301

Q12908
FKVFKSYCENHLGST

ORC3

476

Q9UBD5
SFSNYLKKYHNTICG

MEMO1

231

Q9Y316
SVFLLSHKCFGYYIH

TMEM67

776

Q5HYA8
CGYELFSSRSKYAHS

MSRB1

26

Q9NZV6
FIKKGSCYALTYNTH

RPP40

86

O75818
VKGDKVESYHCYSLQ

NTMT2

161

Q5VVY1
TSVAYGCIKYADLSH

RARS1

496

P54136
QCYEFLTLHTVKKYF

USP9X

261

Q93008
KAEIDDKTYSYQCHG

SLFN14

61

P0C7P3
KSYLNKHYESACFKG

SCRT1

316

Q9BWW7
HSYKSNCKNFLDTYG

TMEM131L

926

A2VDJ0
YGHSQKKHKCSVYYS

TMEM131L

971

A2VDJ0
HICYEAKFSIYVDSK

TMEM217B

31

A0A494BZU4
TGQHCEKKDYSVLYV

TMEFF2

296

Q9UIK5
YELHVHCKTSFVGYF

MOV10

196

Q9HCE1
GFTWIKHYCTYDKGS

ARHGAP42

281

A6NI28
ASSKGDHLTTIFYYC

SMG7

196

Q92540
DCSHLYDYTVKLLFK

HIP1

231

O00291
HYKSCKKYQDEYGVS

RNF138

101

Q8WVD3
LAGTFHYYSCERAKK

NSDHL

331

Q15738
VCHFKKGTEICNYSY

WIPI2

101

Q9Y4P8
SKYAVVKCSKSGDLY

IARS2

316

Q9NSE4
HAIQKYFSAKSGVYC

SUPV3L1

216

Q8IYB8
IHAYGKKESCITYHL

ABCC12

1001

Q96J65
YDHLKTQGCSIYKDY

PLA2G2D

71

Q9UNK4
VYSTKAKNYVNGHCT

SGPL1

21

O95470
FSAIYFPCYAHVKAS

SLC25A13

496

Q9UJS0
LKASLGTTKYCSYFL

CNOT4

186

O95628
SALYFHIGETEKKCF

TMED9

36

Q9BVK6
SCYLDGCYSHKKFQL

TECTA

1716

O75443
KFHTEVKYYECIACG

ZNF132

311

P52740
YKYEECGKVFSQSSH

ZNF107

216

Q9UII5
CGKTFRYSSSLYKHS

ZNF684

276

Q5T5D7
KTYTGHKNEKYCIFA

WDR5B

246

Q86VZ2
YDGCGKLYTTAHHLK

ZNF143

241

P52747
HTKCKSYGSHLFDYA

ZNF596

161

Q8TC21
AGSTLIFYKYCDHEN

TOR1AIP1

486

Q5JTV8
IKFNHCEKYIYSFSV

MKRN2OS

11

H3BPM6
LGKAACYAHLYVTDV

SPEG

1266

Q15772
KVSYFHCTLIGYFVG

SPPL3

311

Q8TCT6
CGKSYYRKSTLITHQ

RBAK

406

Q9NYW8
CGKVFSQKSYLTVHY

RBAK

656

Q9NYW8
ARYHYDGICIKKSSF

RFX8

86

Q6ZV50
YLEHASKYLAFTCGL

TRAPPC6B

111

Q86SZ2
ECGKAFNYRSYLTTH

ZNF267

636

Q14586
HDTVKKFYTCGYCTE

ZNF592

1036

Q92610
TKGYASVFKGCLTLY

NABP2

71

Q9BQ15
YYCSKTPASFRKDNH

TBC1D23

281

Q9NUY8
GYCSYKASKRFSSLH

VN1R1

206

Q9GZP7
YKYTVCDKSFHQSSA

ZNF322

351

Q6U7Q0
YKVSLGKTDAFICKY

THUMPD2

481

Q9BTF0
YALSYLSEDGCKHFL

SH2D4A

381

Q9H788
IYSFHCEYVSSLSKK

ATP6AP1

366

Q15904
SCIYGEGYSNTHKSK

nan

41

A8MWL6
YECKECGKAFIYHTT

ZNF709

196

Q8N972
CYTIAQKYLFEGKHE

ZMYND12

91

Q9H0C1
THIGDTSYKYLECDK

ZNF430

506

Q9H8G1
KVIISDKHCFELYGY

TTLL9

311

Q3SXZ7
CDKAFAYNSYLAKHS

ZNF28

416

P17035
NCSVLTKTKYTHYYG

SFMBT1

626

Q9UHJ3
SECGKFFTYHSSLIK

ZNF154

276

Q13106
KKTVHYYAELGQCSV

PLK2

541

Q9NYY3
KSALQEACLLYGYSH

ZCWPW2

176

Q504Y3
TECGKSYSHKYGLIT

ZNF614

486

Q8N883
TYTGHKNEKYCIFAN

WDR5

251

P61964
HSTHLGEKSYKCDQY

ZNF285

251

Q96NJ3
GCGKRFTEYSSLYKH

ZNF76

321

P36508
YACKECGKNIIYHSS

ZNF439

186

Q8NDP4
SSQHGYYEKLCLEKS

TRAIP

331

Q9BWF2
KFICSHCSYISYTKG

ZNF518B

161

Q9C0D4
CGKAFYKKYRLTEHE

ZNF649

211

Q9BS31
VYTTLKGLYATHACG

TH

266

P07101
DLYHCLVSKDHGKVY

VPS13D

4306

Q5THJ4
YAGCGKTYTKSSHLK

KLF2

276

Q9Y5W3
IKEHLCKLTFYYGTI

LDAH

256

Q9H6V9
KFYASSGEHEKCGQY

MYOF

1456

Q9NZM1