Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	SOX3 TCF3 ZNF784 ONECUT1 MYT1 MAFA ZIC3	4.07e-06	560	25	7	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	SOX3 TCF3 ZNF784 ONECUT1 MYT1 MAFA ZIC3	4.37e-06	566	25	7	GO:0001216
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SOX3 TCF3 SOX8 ZNF784 ONECUT1 GLI3 MYT1 MAFA ZIC3	1.13e-05	1244	25	9	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	SOX3 TCF3 SOX8 ZNF784 ONECUT1 GLI3 MYT1 MAFA ZIC3	1.34e-05	1271	25	9	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	SOX3 TCF3 SOX8 ZNF784 ONECUT1 GLI3 MYT1 MAFA ZIC3	3.12e-05	1412	25	9	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	SOX3 TCF3 SOX8 ZNF784 ONECUT1 GLI3 MYT1 MAFA ZIC3	4.04e-05	1459	25	9	GO:0000977
GeneOntologyMolecularFunction	transition metal ion binding	SLC30A7 FBXO11 IDE HRNR FLG2 KNG1 MYT1	4.85e-04	1189	25	7	GO:0046914
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	SOX3 TCF3 SOX8 ZNF784 ONECUT1 GLI3 MYT1 MAFA ZIC3	2.12e-05	1390	25	9	GO:0045944
GeneOntologyBiologicalProcess	limbic system development	SOX3 PRDM13 GLI3 ZIC3	2.37e-05	141	25	4	GO:0021761
GeneOntologyBiologicalProcess	negative regulation of neuron differentiation	SOX3 SOX8 GLI3	1.96e-04	94	25	3	GO:0045665
GeneOntologyBiologicalProcess	epithelium development	SAFB2 HRNR SOX8 SLC12A2 FLG2 ONECUT1 GLI3 ZIC3	2.35e-04	1469	25	8	GO:0060429
GeneOntologyBiologicalProcess	regulation of neuron differentiation	SOX3 TCF3 SOX8 GLI3	2.35e-04	255	25	4	GO:0045664
GeneOntologyBiologicalProcess	pancreas development	ONECUT1 MYT1 ZIC3	2.50e-04	102	25	3	GO:0031016
GeneOntologyCellularComponent	keratohyalin granule	HRNR FLG2	1.37e-05	5	25	2	GO:0036457
MousePheno	postnatal growth retardation	SLC30A7 SOX3 TCF3 SOX8 SLC12A2 ONECUT1 MAFA ZIC3	1.54e-05	881	20	8	MP:0001732
MousePheno	abnormal postnatal growth	SLC30A7 SOX3 TCF3 SOX8 SLC12A2 ONECUT1 MAFA ZIC3	1.90e-05	907	20	8	MP:0001731
MousePheno	abnormal interfrontal bone morphology	GLI3 ZIC3	1.94e-05	5	20	2	MP:0008818
MousePheno	abnormal Sertoli cell morphology	SOX3 SAFB2 SOX8	1.58e-04	75	20	3	MP:0002784
Domain	S100_CABP	HRNR FLG2	6.91e-04	27	27	2	PS00303
Domain	S_100	HRNR FLG2	6.91e-04	27	27	2	PF01023
Domain	S100_Ca-bd_sub	HRNR FLG2	7.43e-04	28	27	2	IPR013787
Domain	S100/CaBP-9k_CS	HRNR FLG2	7.43e-04	28	27	2	IPR001751
Domain	S_100	HRNR FLG2	7.43e-04	28	27	2	SM01394
Domain	HMG_box	SOX3 SOX8	2.65e-03	53	27	2	PF00505
Domain	HMG_BOX_2	SOX3 SOX8	2.75e-03	54	27	2	PS50118
Domain	HMG	SOX3 SOX8	2.75e-03	54	27	2	SM00398
Domain	-	SOX3 SOX8	2.85e-03	55	27	2	1.10.30.10
Domain	EF_HAND_1	EFCC1 HRNR FLG2	3.10e-03	204	27	3	PS00018
Domain	HMG_box_dom	SOX3 SOX8	3.96e-03	65	27	2	IPR009071
Domain	EF_HAND_2	EFCC1 HRNR FLG2	4.39e-03	231	27	3	PS50222
Domain	EF_hand_dom	EFCC1 HRNR FLG2	4.44e-03	232	27	3	IPR002048
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	SOX3 SOX8 ZNF784 ONECUT1 GLI3 MAFA ZIC3	1.49e-07	544	27	7	28473536
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	SLC30A7 SAFB2 PSMD1 FBXO11 SLC12A2 ONECUT1 GLI3 MAFA ZIC3	1.84e-07	1203	27	9	29180619
Pubmed	Characterization of the interactions of human ZIC3 mutants with GLI3.	GLI3 ZIC3	5.80e-07	2	27	2	17764085
Pubmed	Disruption of GLI3-ZIC3 interaction in the cadmium-induced omphalocele chick model.	GLI3 ZIC3	5.80e-07	2	27	2	21069353
Pubmed	Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.	HRNR FLG2	1.74e-06	3	27	2	23403047
Pubmed	Preaxial polydactyly caused by Gli3 haploinsufficiency is rescued by Zic3 loss of function in mice.	GLI3 ZIC3	1.74e-06	3	27	2	22234993
Pubmed	Transcription factor cycling on the insulin promoter.	TCF3 MAFA	1.74e-06	3	27	2	16412423
Pubmed	Regulation of the orphan nuclear receptor steroidogenic factor 1 by Sox proteins.	SOX3 SOX8	3.48e-06	4	27	2	11875113
Pubmed	Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins.	GLI3 ZIC3	3.48e-06	4	27	2	11053430
Pubmed	A census of human transcription factors: function, expression and evolution.	SOX3 TCF3 SOX8 ONECUT1 GLI3 MYT1 MAFA	4.54e-06	908	27	7	19274049
Pubmed	Extracellular Hsp90α and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1.	HRNR FLG2 HPX	5.41e-06	44	27	3	31273033
Pubmed	A novel function of Onecut1 protein as a negative regulator of MafA gene expression.	ONECUT1 MAFA	8.69e-06	6	27	2	23775071
Pubmed	Physical and functional interactions between Zic and Gli proteins.	GLI3 ZIC3	8.69e-06	6	27	2	11238441
Pubmed	The interfrontal bone and mutant genes in the mouse.	GLI3 ZIC3	1.62e-05	8	27	2	1018005
Pubmed	CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA.	GLI3 ZIC3	2.60e-05	10	27	2	18298960
Pubmed	Onecut Factors and Pou2f2 Regulate the Distribution of V2 Interneurons in the Mouse Developing Spinal Cord.	ONECUT1 MAFA	2.60e-05	10	27	2	31231191
Pubmed	Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators.	SOX3 SOX8	3.81e-05	12	27	2	11071752
Pubmed	Seven new members of the Sox gene family expressed during mouse development.	SOX3 SOX8	4.50e-05	13	27	2	8441686
Pubmed	Sox2 and Pax6 maintain the proliferative and developmental potential of gliogenic neural stem cells In vitro.	SOX3 GLI3	5.25e-05	14	27	2	21766338
Pubmed	Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation.	ONECUT1 MAFA	5.25e-05	14	27	2	19766716
Pubmed	Essential role of MESP1-RING1A complex in cardiac differentiation.	TCF3 ZIC3	6.06e-05	15	27	2	36413948
Pubmed	Impact of transcription factor Sox8 on oligodendrocyte specification in the mouse embryonic spinal cord.	SOX3 SOX8	6.06e-05	15	27	2	15893981
Pubmed	Differential isoform expression and alternative splicing in sex determination in mice.	SOX3 SOX8	6.06e-05	15	27	2	30871468
Pubmed	Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function.	MYT1 MAFA	6.92e-05	16	27	2	19487660
Pubmed	TRIM30 modulates Interleukin-22-regulated papillary thyroid Cancer cell migration and invasion by targeting Sox17 for K48-linked Polyubiquitination.	HRNR FLG2	6.92e-05	16	27	2	31823782
Pubmed	Sox2 is required for embryonic development of the ventral telencephalon through the activation of the ventral determinants Nkx2.1 and Shh.	SOX3 GLI3	7.84e-05	17	27	2	23444355
Pubmed	Spatio-temporal expression of Sox genes in murine palatogenesis.	SOX3 SOX8	7.84e-05	17	27	2	27241892
Pubmed	Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse.	MYT1 MAFA	7.84e-05	17	27	2	17928203
Pubmed	Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits.	ONECUT1 MAFA	8.81e-05	18	27	2	31969659
Pubmed	Expression of Sox genes in tooth development.	SOX3 SOX8	8.81e-05	18	27	2	26864488
Pubmed	The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells.	MYT1 MAFA	8.81e-05	18	27	2	17537793
Pubmed	Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource.	IDE KNG1	9.84e-05	19	27	2	23912999
Pubmed	Molecular evolution of Sry and Sox gene.	SOX3 TCF3	1.09e-04	20	27	2	11404013
Pubmed	Expression of Sox transcription factors in the developing mouse pancreas.	SOX3 SOX8	1.21e-04	21	27	2	12815626
Pubmed	Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.	HRNR FLG2	1.21e-04	21	27	2	19601998
Pubmed	NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas.	MYT1 MAFA	1.21e-04	21	27	2	15944193
Pubmed	The mammal-specific Pdx1 Area II enhancer has multiple essential functions in early endocrine cell specification and postnatal β-cell maturation.	ONECUT1 MAFA	1.33e-04	22	27	2	27993987
Pubmed	SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function.	SOX3 SOX8	1.33e-04	22	27	2	17084361
Pubmed	Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression.	ONECUT1 MAFA	1.45e-04	23	27	2	19805515
Pubmed	E3 Ligase Trim21 Ubiquitylates and Stabilizes Keratin 17 to Induce STAT3 Activation in Psoriasis.	PSMD1 HRNR FLG2	1.56e-04	135	27	3	29859926
Pubmed	Reconstituting pancreas development from purified progenitor cells reveals genes essential for islet differentiation.	ONECUT1 MAFA	1.59e-04	24	27	2	23852729
Pubmed	T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number.	GLI3 ZIC3	1.72e-04	25	27	2	27046536
Pubmed	The Krüppel-like zinc finger protein GLIS3 transactivates neurogenin 3 for proper fetal pancreatic islet differentiation in mice.	ONECUT1 MAFA	1.72e-04	25	27	2	21786021
Pubmed	Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun.	TCF3 GLI3 ZIC3	1.74e-04	140	27	3	26930384
Pubmed	Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells.	SOX3 ZIC3	1.86e-04	26	27	2	22992956
Pubmed	Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2.	ONECUT1 MAFA	1.86e-04	26	27	2	28193997
Pubmed	Functional and Evolutionary Diversification of Otx2 and Crx in Vertebrate Retinal Photoreceptor and Bipolar Cell Development.	PRDM13 ONECUT1	2.01e-04	27	27	2	31968244
Pubmed	Insights into the etiology and physiopathology of MODY5/HNF1B pancreatic phenotype with a mouse model of the human disease.	ONECUT1 MAFA	2.33e-04	29	27	2	33527355
Pubmed	Legacy Effect of Foxo1 in Pancreatic Endocrine Progenitors on Adult β-Cell Mass and Function.	ONECUT1 MAFA	2.33e-04	29	27	2	25784544
Pubmed	Single-cell transcriptomic landscapes of the otic neuronal lineage at multiple early embryonic ages.	SOX3 MYT1	2.49e-04	30	27	2	35320729
Pubmed	SOX1 links the function of neural patterning and Notch signalling in the ventral spinal cord during the neuron-glial fate switch.	SOX3 SOX8	2.66e-04	31	27	2	19723505
Pubmed	Dynamic Interaction of USP14 with the Chaperone HSC70 Mediates Crosstalk between the Proteasome, ER Signaling, and Autophagy.	PSMD1 HRNR	2.66e-04	31	27	2	31901637
Pubmed	Threshold-Dependent Cooperativity of Pdx1 and Oc1 in Pancreatic Progenitors Establishes Competency for Endocrine Differentiation and β-Cell Function.	ONECUT1 MAFA	2.84e-04	32	27	2	27292642
Pubmed	NFIA controls telencephalic progenitor cell differentiation through repression of the Notch effector Hes1.	SOX3 SOX8	2.84e-04	32	27	2	20610746
Pubmed	Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development.	TCF3 GLI3	3.02e-04	33	27	2	27414999
Pubmed	MITOL regulates phosphatidic acid-binding activity of RMDN3/PTPIP51.	PSMD1 FBXO11	4.67e-04	41	27	2	34964862
Pubmed	Spatiotemporal regulation of GLI target genes in the mammalian limb bud.	XPNPEP2 GLI3 ZIC3	5.47e-04	207	27	3	26238476
Pubmed	Let-7b and miR-495 stimulate differentiation and prevent metaplasia of pancreatic acinar cells by repressing HNF6.	ONECUT1 MAFA	5.88e-04	46	27	2	23684747
Pubmed	Characterization of LGALS3 (galectin-3) as a player in DNA damage response.	HRNR SLC12A2	5.88e-04	46	27	2	24755837
Pubmed	Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.	KNG1 HPX	6.14e-04	47	27	2	14760718
Pubmed	Human transcription factor protein interaction networks.	PSMD1 TCF3 HRNR FLG2 GLI3 ZIC3	6.70e-04	1429	27	6	35140242
Interaction	RNF4 interactions	SLC30A7 SAFB2 PSMD1 FBXO11 SLC12A2 ONECUT1 GLI3 MAFA ZIC3	2.90e-05	1412	25	9	int:RNF4
Cytoband	1q21.3	HRNR FLG2	2.17e-03	117	27	2	1q21.3
Cytoband	Ensembl 112 genes in cytogenetic band chrXq26	XPNPEP2 ZIC3	4.55e-03	171	27	2	chrXq26
GeneFamily	EF-hand domain containing\|S100 fused type protein family	HRNR FLG2	3.53e-05	7	24	2	1350
GeneFamily	SRY-boxes	SOX3 SOX8	2.85e-04	19	24	2	757
GeneFamily	EF-hand domain containing	EFCC1 HRNR FLG2	2.94e-03	219	24	3	863
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW10\|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.	SOX3 TCF3 GLI3 MYT1	6.02e-06	199	27	4	8e72efcd421639ac36ed036ee13f13de070d361f
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	SOX3 TCF3 GLI3 MYT1	6.14e-06	200	27	4	7c495030e6566b81d97b5516d1972e335ce5ed8c
Disease	dentate gyrus volume measurement	RNFT2 GLI3	5.42e-04	39	26	2	EFO_0010083
Disease	hippocampal CA4 volume	RNFT2 GLI3	5.99e-04	41	26	2	EFO_0009396
Disease	Anorectal Malformations	GLI3 ZIC3	5.99e-04	41	26	2	C3495676

Protein segments in the cluster

Peptide	Gene	Start	Entry
YQDVGGHAHGSGLGG	C1orf167	111	Q5SNV9
FGHFGGANHAHTLGE	EFCC1	441	Q9HA90
HSGHAHGQAGSQHGE	FLG2	2046	Q5D862
DGGAHGYGRRHLQPH	GLI3	981	P10071
AGHGGGAGHHVRLEE	MAFA	211	Q8NHW3
GHGGTHGFGYGVGHG	MUC22	1736	E2RYF6
HGFGYGVGHGLSHIH	MUC22	1741	E2RYF6
GVGHGLSHIHGDGYG	MUC22	1746	E2RYF6
LSHIHGDGYGVNHGG	MUC22	1751	E2RYF6
GDGYGVNHGGHYGHG	MUC22	1756	E2RYF6
ASLLDGGSGGGDYHH	ONECUT1	56	Q9UBC0
QHGSGSGHSSGYGQH	HRNR	246	Q86YZ3
QVSLHHGGGHICGGS	PRSS36	61	Q5K4E3
DGQHGGIYVHEKGQG	FBXO11	591	Q86XK2
GGHSHGPGVYHHGAI	GGT6	96	Q6P531
QRGHGLGHGHEQQHG	KNG1	456	P01042
GHYLGHLIGHEGPGS	IDE	331	P14735
VFSGGGGGAFLHHEH	PRDM13	161	Q9H4Q3
SGENSAAGGAGHHHH	PRDM13	341	Q9H4Q3
GTGHGNSTHHGPEYM	HPX	241	P02790
FHHGGHRGGSLLQHV	RNFT2	116	Q96EX2
GRLHGVHQHYQGAGT	SOX3	421	P41225
GGLYALGLIHANHGG	PSMD1	441	Q99460
VYKAEAGLGDGHHHG	SOX8	201	P57073
AGLGDGHHHGDHTGQ	SOX8	206	P57073
PQGSGYANALGHHHH	ZIC3	76	O60481
GGLHQHERMGYQLHG	TCF3	266	P15923
HSGGGGGSGHHQHYY	SLC12A2	186	P55011
DGQHYGDDRHGHGGP	SAFB2	796	Q14151
IFVFKHGGHGHSHGS	SLC30A7	156	Q8NEW0
LNYGHGTGHGIGNFL	XPNPEP2	516	O43895
LFHEHGHLAGAEGGG	ZNF784	81	Q8NCA9
GCDGTGHVTGLYPHH	MYT1	446	Q01538