Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcesspositive regulation of Arp2/3 complex-mediated actin nucleation

ABI2 WASF3

3.93e-058252GO:2000601
GeneOntologyBiologicalProcessregulation of cellular component biogenesis

TBC1D8 CDKL5 PAN3 RPL13A ABI2 SYNE1 SVIL EIF4G1

5.33e-051189258GO:0044087
GeneOntologyBiologicalProcessplasma membrane bounded cell projection assembly

TBC1D8 CDKL5 CELSR3 ABI2 SYNE1 WASF3

1.20e-04670256GO:0120031
GeneOntologyBiologicalProcessregulation of organelle organization

TBC1D8 CDKL5 MSX2 PAN3 ABI2 SYNE1 SVIL WASF3

1.25e-041342258GO:0033043
GeneOntologyBiologicalProcesspositive regulation of actin nucleation

ABI2 WASF3

1.27e-0414252GO:0051127
GeneOntologyBiologicalProcesscell projection assembly

TBC1D8 CDKL5 CELSR3 ABI2 SYNE1 WASF3

1.35e-04685256GO:0030031
GeneOntologyBiologicalProcesspositive regulation of cellular component organization

CDKL5 MSX2 PAN3 NFATC2 ABI2 SYNE1 WASF3 EIF4G1

1.42e-041366258GO:0051130
GeneOntologyBiologicalProcessregulation of mesenchymal cell apoptotic process

MSX2 SYNE1

1.90e-0417252GO:2001053
GeneOntologyBiologicalProcessregulation of plasma membrane bounded cell projection assembly

TBC1D8 CDKL5 ABI2 SYNE1

2.12e-04248254GO:0120032
GeneOntologyBiologicalProcessregulation of cell projection assembly

TBC1D8 CDKL5 ABI2 SYNE1

2.21e-04251254GO:0060491
GeneOntologyBiologicalProcessosteoblast development

MSX2 RUNX2

2.38e-0419252GO:0002076
GeneOntologyBiologicalProcessmesenchymal cell apoptotic process

MSX2 SYNE1

2.38e-0419252GO:0097152
GeneOntologyBiologicalProcessregulation of cilium assembly

TBC1D8 CDKL5 SYNE1

2.95e-04108253GO:1902017
GeneOntologyBiologicalProcessregulation of organelle assembly

TBC1D8 CDKL5 PAN3 SYNE1

3.36e-04280254GO:1902115
GeneOntologyBiologicalProcessbranching involved in mammary gland duct morphogenesis

ETV5 MSX2

6.01e-0430252GO:0060444
GeneOntologyBiologicalProcessregulation of Arp2/3 complex-mediated actin nucleation

ABI2 WASF3

6.42e-0431252GO:0034315
GeneOntologyBiologicalProcessembryonic forelimb morphogenesis

MSX2 RUNX2

9.15e-0437252GO:0035115
GeneOntologyBiologicalProcesschondrocyte development

MSX2 RUNX2

1.12e-0341252GO:0002063
GeneOntologyBiologicalProcessregulation of actin nucleation

ABI2 WASF3

1.12e-0341252GO:0051125
GeneOntologyBiologicalProcessregulation of synapse organization

ETV5 CDKL5 ABI2 EIF4G1

1.13e-03387254GO:0050807
GeneOntologyBiologicalProcessnegative regulation of smoothened signaling pathway

RUNX2 UBR5

1.18e-0342252GO:0045879
GeneOntologyBiologicalProcesssynapse organization

ETV5 CDKL5 ABI2 WASF3 EIF4G1

1.22e-03685255GO:0050808
GeneOntologyBiologicalProcessregulation of synapse structure or activity

ETV5 CDKL5 ABI2 EIF4G1

1.22e-03395254GO:0050803
GeneOntologyBiologicalProcesscytoplasmic translational initiation

RPL13A EIF4G1

1.35e-0345252GO:0002183
GeneOntologyBiologicalProcessmammary gland duct morphogenesis

ETV5 MSX2

1.35e-0345252GO:0060603
GeneOntologyBiologicalProcessArp2/3 complex-mediated actin nucleation

ABI2 WASF3

1.47e-0347252GO:0034314
GeneOntologyBiologicalProcessforelimb morphogenesis

MSX2 RUNX2

1.54e-0348252GO:0035136
GeneOntologyBiologicalProcessregulation of anatomical structure morphogenesis

ETV5 CDKL5 RUNX2 ABI2 SYNE1 WASF3

1.60e-031090256GO:0022603
GeneOntologyBiologicalProcessdendrite morphogenesis

CDKL5 ABI2 SYNE1

1.71e-03198253GO:0048813
GeneOntologyBiologicalProcesscilium assembly

TBC1D8 CDKL5 CELSR3 SYNE1

1.87e-03444254GO:0060271
GeneOntologyCellularComponentSCAR complex

ABI2 WASF3

9.00e-0512252GO:0031209
GeneOntologyCellularComponentpostsynapse

CDKL5 CELSR3 RPL13A ABI2 SYNE1 WASF3 EIF4G1

1.41e-041018257GO:0098794
MousePhenoabnormal cervical loop morphology

MSX2 RUNX2

7.76e-063232MP:0030521
MousePhenoabnormal dental epithelium morphology

MSX2 RUNX2

7.21e-058232MP:0030508
Domainp53-like_TF_DNA-bd

RUNX2 NFATC2

2.27e-0353252IPR008967
DomainZnf_CCCH

PAN3 ZC3HAV1

2.72e-0358252IPR000571
DomainZF_C3H1

PAN3 ZC3HAV1

2.72e-0358252PS50103
DomainCH

LMO7 SYNE1

3.40e-0365252SM00033
DomainCH

LMO7 SYNE1

3.93e-0370252PF00307
Domain-

LMO7 SYNE1

4.04e-03712521.10.418.10
DomainCH

LMO7 SYNE1

4.26e-0373252PS50021
DomainCH-domain

LMO7 SYNE1

4.50e-0375252IPR001715
PathwayBIOCARTA_ACTINY_PATHWAY

ABI2 WASF3

8.55e-0510202MM1528
PathwayBIOCARTA_ACTINY_PATHWAY

ABI2 WASF3

1.25e-0412202M7825
PathwayREACTOME_REGULATION_OF_RUNX2_EXPRESSION_AND_ACTIVITY

PSMB8 MSX2 RUNX2

1.37e-0472203M27802
PathwayREACTOME_DEADENYLATION_OF_MRNA

PAN3 EIF4G1

5.18e-0424202MM15090
PathwayREACTOME_DEADENYLATION_OF_MRNA

PAN3 EIF4G1

5.63e-0425202M13492
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX2

PSMB8 MSX2 RUNX2

6.02e-04119203M27785
Pubmed

Regulation of the activity of the transcription factor Runx2 by two homeobox proteins, Msx2 and Dlx5.

MSX2 RUNX2

5.80e-07227211683913
Pubmed

Regulation of NFATc2 gene expression by the transcription factor Runx2.

RUNX2 NFATC2

5.80e-07227217103021
Pubmed

Role of Msx2 as a promoting factor for Runx2 at the periodontal tension sides elicited by mechanical stress.

MSX2 RUNX2

5.80e-07227218948234
Pubmed

Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

FAM13A UBR5 LMO7 WASF3

1.07e-0610027410048485
Pubmed

Conserved regulatory motifs in osteogenic gene promoters integrate cooperative effects of canonical Wnt and BMP pathways.

MSX2 RUNX2

1.74e-06327220878775
Pubmed

FGF2 induced expression of the pyrophosphate generating enzyme, PC-1, is mediated by Runx2 and Msx2.

MSX2 RUNX2

1.74e-06327219147956
Pubmed

PKC signaling inhibits osteogenic differentiation through the regulation of Msx2 function.

MSX2 RUNX2

1.74e-06327222633971
Pubmed

Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter.

MSX2 RUNX2

1.74e-06327216115867
Pubmed

Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells.

MSX2 RUNX2

1.74e-06327212750290
Pubmed

mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.

PAN3 LMO7 SVIL EIF4G1 ZC3HAV1

2.05e-0627427534244482
Pubmed

BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation.

MSX2 RUNX2

3.48e-06427218703512
Pubmed

Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene.

MSX2 RUNX2

3.48e-06427215456894
Pubmed

Homeobox protein MSX2 acts as a molecular defense mechanism for preventing ossification in ligament fibroblasts.

MSX2 RUNX2

3.48e-06427215060165
Pubmed

Gene expression of runx2, Osterix, c-fos, DLX-3, DLX-5, and MSX-2 in dental follicle cells during osteogenic differentiation in vitro.

MSX2 RUNX2

5.80e-06527216467978
Pubmed

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1.

RUNX2 NFATC2

5.80e-06527217377532
Pubmed

MINT, the Msx2 interacting nuclear matrix target, enhances Runx2-dependent activation of the osteocalcin fibroblast growth factor response element.

MSX2 RUNX2

5.80e-06527215131132
Pubmed

Runx2 trans-activation mediated by the MSX2-interacting nuclear target requires homeodomain interacting protein kinase-3.

MSX2 RUNX2

5.80e-06527220484411
Pubmed

Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes.

MSX2 RUNX2

5.80e-06527237102702
Pubmed

Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.

CDKL5 RPL13A LMO7 SVIL ZC3HAV1

7.84e-0636127530344098
Pubmed

Alx4 and Msx2 play phenotypically similar and additive roles in skull vault differentiation.

MSX2 RUNX2

8.69e-06627215198690
Pubmed

Msx2 and Twist cooperatively control the development of the neural crest-derived skeletogenic mesenchyme of the murine skull vault.

MSX2 RUNX2

8.69e-06627214597577
Pubmed

Cell fate specification during calvarial bone and suture development.

MSX2 RUNX2

8.69e-06627217931618
Pubmed

Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex.

MSX2 RUNX2

1.22e-05727212145306
Pubmed

Impaired meningeal development in association with apical expansion of calvarial bone osteogenesis in the Foxc1 mutant.

MSX2 RUNX2

1.22e-05727218422524
Pubmed

The canonical BMP signaling pathway plays a crucial part in stimulation of dentin sialophosphoprotein expression by BMP-2.

MSX2 RUNX2

1.22e-05727220843790
Pubmed

Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation.

MSX2 RUNX2

1.22e-05727215175325
Pubmed

Nell-1, a key functional mediator of Runx2, partially rescues calvarial defects in Runx2(+/-) mice.

MSX2 RUNX2

1.22e-05727220939017
Pubmed

Chondrogenic potential of mouse calvarial mesenchyme.

MSX2 RUNX2

1.62e-05827215872058
Pubmed

Molecular mechanisms in calvarial bone and suture development, and their relation to craniosynostosis.

MSX2 RUNX2

1.62e-05827212737212
Pubmed

Tbx22null mice have a submucous cleft palate due to reduced palatal bone formation and also display ankyloglossia and choanal atresia phenotypes.

MSX2 RUNX2

2.08e-05927219648291
Pubmed

Foxc1 controls the growth of the murine frontal bone rudiment by direct regulation of a Bmp response threshold of Msx2.

MSX2 RUNX2

2.08e-05927223344708
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

RPL13A ANKHD1 UBR5 LMO7 SVIL EIF4G1 ZC3HAV1

2.10e-05114927735446349
Pubmed

GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.

RPL13A UBR5 EIF4G1 ZC3HAV1

2.48e-0522127429991511
Pubmed

FGF9 monomer-dimer equilibrium regulates extracellular matrix affinity and tissue diffusion.

ETV5 RUNX2

2.60e-051027219219044
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

UBR5 LMO7 SYNE1 WASF3

2.66e-0522527412168954
Pubmed

FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis.

MSX2 RUNX2

3.18e-051127211937494
Pubmed

Prickle1 regulates differentiation of frontal bone osteoblasts.

MSX2 RUNX2

3.18e-051127230575813
Pubmed

Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation.

MSX2 RUNX2

3.18e-051127210742104
Pubmed

Progression of calvarial bone development requires Foxc1 regulation of Msx2 and Alx4.

MSX2 RUNX2

3.18e-051127214512019
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

PAN3 FAM13A LMO7 SVIL EIF4G1 ZC3HAV1

4.29e-0586127636931259
Pubmed

The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.

MUC13 LMO7 EIF4G1 ZC3HAV1

4.40e-0525627433397691
Pubmed

Molecular markers of cardiac endocardial cushion development.

MSX2 RUNX2

4.50e-051327214648841
Pubmed

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.

RPL13A UBR5 LMO7 HSPB8

4.82e-0526227436880596
Pubmed

Requirement for Twist1 in frontonasal and skull vault development in the mouse embryo.

MSX2 RUNX2

5.25e-051427219414008
Pubmed

Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis.

MSX2 RUNX2

5.25e-051427217194222
Pubmed

Regulation of cranial morphogenesis and cell fate at the neural crest-mesoderm boundary by engrailed 1.

MSX2 RUNX2

5.25e-051427222395741
Pubmed

The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development.

MSX2 RUNX2

5.25e-051427212000792
Pubmed

Concerted action of Msx1 and Msx2 in regulating cranial neural crest cell differentiation during frontal bone development.

MSX2 RUNX2

5.25e-051427217693062
Pubmed

ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.

RPL13A LMO7 EIF4G1 ZC3HAV1

5.26e-0526827433024031
Pubmed

Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.

PSMB8 RPL13A ANKHD1 UBR5 EIF4G1

5.30e-0553827528524877
Pubmed

The RNA-binding protein Snd1/Tudor-SN regulates hypoxia-responsive gene expression.

ANKHD1 EIF4G1 ZC3HAV1

5.86e-059727337151849
Pubmed

Dephosphorylation of the transcriptional cofactor NACA by the PP1A phosphatase enhances cJUN transcriptional activity and osteoblast differentiation.

LMO7 SVIL

6.06e-051527230948508
Pubmed

Prevention of premature fusion of calvarial suture in GLI-Kruppel family member 3 (Gli3)-deficient mice by removing one allele of Runt-related transcription factor 2 (Runx2).

MSX2 RUNX2

6.06e-051527222547067
Pubmed

Dlx5-augmentation in neural crest cells reveals early development and differentiation potential of mouse apical head mesenchyme.

MSX2 RUNX2

6.06e-051527233483579
Pubmed

Prx1 and Prx2 cooperatively regulate the morphogenesis of the medial region of the mandibular process.

MSX2 RUNX2

6.06e-051527219777594
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

CDKL5 LMO7 SVIL EIF4G1 ZC3HAV1

6.68e-0556527525468996
Pubmed

A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer.

ANKHD1 LMO7 EIF4G1 ZC3HAV1

6.77e-0528627432041737
Pubmed

LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression.

MUC13 RPL13A LMO7 SVIL EIF4G1

7.55e-0558027535676659
Pubmed

Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1.

RUNX2 NFATC2

7.84e-051727222457635
Pubmed

Wnt signaling in the murine diastema.

MSX2 RUNX2

7.84e-051727221531785
Pubmed

Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.

ANKHD1 EIF4G1 ZC3HAV1

7.85e-0510727330995489
Pubmed

Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy.

RPL13A EIF4G1 ZC3HAV1

8.29e-0510927329511296
Pubmed

Human transcription factor protein interaction networks.

ETV5 PAN3 RPL13A ANKHD1 SVIL EIF4G1 ZC3HAV1

8.39e-05142927735140242
Pubmed

Downregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesis.

MSX2 RUNX2

8.81e-051827221558373
Pubmed

Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development.

MSX2 RUNX2

8.81e-051827220386744
Pubmed

Tissue-specific roles of FGF signaling in external genitalia development.

ETV5 MSX2

8.81e-051827225820239
Pubmed

Twist1 contributes to cranial bone initiation and dermal condensation by maintaining Wnt signaling responsiveness.

MSX2 RUNX2

9.84e-051927226677825
Pubmed

Loss of Wiz Function Affects Methylation Pattern in Palate Development and Leads to Cleft Palate.

ETV5 MSX2

9.84e-051927234150743
Pubmed

Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.

RPL13A LMO7 SVIL EIF4G1 ZC3HAV1

1.08e-0462627533644029
Pubmed

Msx1 and Msx2 in limb mesenchyme modulate digit number and identity.

ETV5 MSX2

1.09e-042027221465616
Pubmed

Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2.

ETV5 MSX2

1.09e-042027221303850
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

RPL13A UBR5 LMO7 SYNE1 SVIL EIF4G1

1.12e-04102427624711643
Pubmed

A protein interaction landscape of breast cancer.

RUNX2 RPL13A UBR5 SVIL ZC3HAV1

1.15e-0463427534591612
Pubmed

Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.

RPL13A LMO7 EIF4G1 ZC3HAV1

1.16e-0432927434316702
Pubmed

Suppressor of Fused restraint of Hedgehog activity level is critical for osteogenic proliferation and differentiation during calvarial bone development.

MSX2 RUNX2

1.21e-042127228794157
Pubmed

Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition.

MSX2 RUNX2

1.21e-042127217303760
Pubmed

MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis.

MSX2 RUNX2

1.21e-042127222632802
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

ANKHD1 UBR5 ATAD2B EIF4G1 ZC3HAV1

1.32e-0465327522586326
Pubmed

DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.

ANKHD1 SYNE1

1.33e-042227212812986
Pubmed

Hedgehog signaling patterns the oral-aboral axis of the mandibular arch.

MSX2 RUNX2

1.33e-042227230638444
Pubmed

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.

RPL13A ANKHD1 UBR5 HSPB8 ZC3HAV1

1.34e-0465527535819319
Pubmed

Neural crest cells require Meis2 for patterning the mandibular arch via the Sonic hedgehog pathway.

MSX2 RUNX2

1.45e-042327232616504
Pubmed

Anti-osteogenic function of a LIM-homeodomain transcription factor LMX1B is essential to early patterning of the calvaria.

MSX2 RUNX2

1.59e-042427229852132
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

ANKHD1 LMO7 SVIL EIF4G1

1.64e-0436027433111431
Pubmed

Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.

PAN3 NFATC2 LMO7 SVIL

1.84e-0437127415747579
Pubmed

Murine craniofacial development requires Hdac3-mediated repression of Msx gene expression.

MSX2 RUNX2

1.86e-042627223506836
Pubmed

The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer.

RPL13A LMO7 SVIL

2.01e-0414727328977470
Pubmed

Novel interactors and a role for supervillin in early cytokinesis.

PAN3 SVIL

2.17e-042827220309963
Pubmed

Dose-dependent effects of Runx2 on bone development.

MSX2 RUNX2

2.17e-042827219419310
Pubmed

Suppression of epithelial differentiation by Foxi3 is essential for molar crown patterning.

ETV5 MSX2

2.49e-043027226450968
Pubmed

Loss of Neogenin alters branchial arch development and leads to craniofacial skeletal defects.

MSX2 RUNX2

2.49e-043027238404688
Pubmed

Single-cell atlas of craniogenesis uncovers SOXC-dependent, highly proliferative, and myofibroblast-like osteodermal progenitors.

MSX2 RUNX2

2.49e-043027235830813
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

FAM13A LMO7 SVIL EIF4G1 ZC3HAV1

2.90e-0477427515302935
Pubmed

Negative regulation of Shh levels by Kras and Fgfr2 during hair follicle development.

ETV5 MSX2

3.21e-043427223123965
Pubmed

Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling.

ETV5 MSX2

3.21e-043427223293290
Pubmed

mTOR plays a pivotal role in multiple processes of enamel organ development principally through the mTORC1 pathway and in part via regulating cytoskeleton dynamics.

MSX2 RUNX2

3.21e-043427232866472
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

RUNX2 RPL13A LMO7 SVIL EIF4G1 ZC3HAV1

3.25e-04124727627684187
Pubmed

ISLET1-Dependent β-Catenin/Hedgehog Signaling Is Required for Outgrowth of the Lower Jaw.

MSX2 RUNX2

3.40e-043527228069742
Pubmed

Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins.

RPL13A ANKHD1

3.40e-043527227812135
Pubmed

GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis.

ETV5 MSX2

3.80e-043727222465667
InteractionEGR4 interactions

NFATC2 ABI2

2.21e-056252int:EGR4
InteractionKIF20A interactions

PAN3 RPL13A UBR5 LMO7 SYNE1 HSPB8 SVIL ZC3HAV1

2.62e-051052258int:KIF20A
InteractionRICTOR interactions

CDKL5 PAN3 ANKHD1 UBR5 HSPB8 SVIL EIF4G1

2.77e-05759257int:RICTOR
InteractionFOS interactions

RUNX2 ANKHD1 NFATC2 LMO7 SVIL

3.55e-05312255int:FOS
InteractionGLDC interactions

PAN3 LMO7 SVIL EIF4G1 ZC3HAV1

4.06e-05321255int:GLDC
InteractionMMP19 interactions

UBR5 SYNE1

6.61e-0510252int:MMP19
InteractionDNAJC1 interactions

TBC1D8 MSX2 RPL13A SYNE1 ZC3HAV1

7.09e-05361255int:DNAJC1
InteractionPML interactions

RUNX2 RPL13A UBR5 LMO7 HSPB8 EIF4G1 ZC3HAV1

1.03e-04933257int:PML
InteractionACTN4 interactions

PSMB8 RPL13A UBR5 LMO7 SVIL

1.15e-04400255int:ACTN4
InteractionBMI1 interactions

RPL13A UBR5 LMO7 SYNE1 EIF4G1 ZC3HAV1

1.24e-04659256int:BMI1
InteractionPRDM15 interactions

RPL13A NFATC2 ZC3HAV1

1.30e-0480253int:PRDM15
InteractionDLGAP4 interactions

CDKL5 ABI2 HSPB8

1.50e-0484253int:DLGAP4
InteractionDISC1 interactions

ANKHD1 UBR5 ABI2 SYNE1 SVIL

1.60e-04429255int:DISC1
InteractionPABPC1 interactions

MSX2 PAN3 RPL13A UBR5 EIF4G1 ZC3HAV1

1.72e-04699256int:PABPC1
InteractionYWHAB interactions

FAM13A NFATC2 ABI2 LMO7 SVIL WASF3 EIF4G1

1.73e-041014257int:YWHAB
InteractionPABPC4 interactions

PAN3 RPL13A UBR5 EIF4G1 ZC3HAV1

1.83e-04442255int:PABPC4
InteractionH1-5 interactions

MSX2 LMO7 SYNE1 SVIL ZC3HAV1

2.28e-04463255int:H1-5
InteractionPPP1CC interactions

CDKL5 RPL13A UBR5 LMO7 SVIL ZC3HAV1

2.30e-04738256int:PPP1CC
InteractionTOP3B interactions

MSX2 ZFYVE26 CELSR3 RPL13A ANKHD1 SVIL EIF4G1 ZC3HAV1

2.76e-041470258int:TOP3B
InteractionYWHAH interactions

PAN3 FAM13A ABI2 LMO7 SVIL EIF4G1 ZC3HAV1

2.89e-041102257int:YWHAH
InteractionVIM interactions

MSX2 NFATC2 UBR5 LMO7 SVIL EIF4G1

3.65e-04804256int:VIM
CytobandEnsembl 112 genes in cytogenetic band chr3q27

ETV5 EIF4G1

2.59e-03128272chr3q27
CytobandEnsembl 112 genes in cytogenetic band chr13q12

PAN3 WASF3

8.35e-03234272chr13q12
CoexpressionGSE18893_CTRL_VS_TNF_TREATED_TCONV_2H_UP

PSMB8 TBC1D8 ANKHD1 SYNE1 ATAD2B

1.73e-06200275M7295
CoexpressionGSE6259_33D1_POS_VS_DEC205_POS_FLT3L_INDUCED_SPLENIC_DC_DN

TBC1D8 ETV5 ZFYVE26 NFATC2

3.19e-05178274M6728
CoexpressionRAF_UP.V1_UP

TBC1D8 ETV5 MSX2 FAM13A

4.38e-05193274M2728
CoexpressionGSE10240_CTRL_VS_IL22_STIM_PRIMARY_BRONCHIAL_EPITHELIAL_CELLS_UP

MUC13 RUNX2 PAN3 ABI2

5.03e-05200274M302
CoexpressionZAIDI_OSTEOBLAST_TRANSCRIPTION_FACTORS

MSX2 RUNX2

9.23e-0514272MM1251
CoexpressionZAIDI_OSTEOBLAST_TRANSCRIPTION_FACTORS

MSX2 RUNX2

9.23e-0514272M6267
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PSMB8 LMO7 SYNE1 ZC3HAV1

3.87e-0617827401dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellCTRL-Myeloid-cDC|CTRL / Disease state, Lineage and Cell class

ZNF469 RUNX2 NFATC2 WASF3

4.32e-0618327420c4d16de7e090df3556a4458f783383a26871b6
ToppCell(4)_Endothelial_cells-(40)_EC-arterial|(4)_Endothelial_cells / Cell class and subclass of bone marrow stroma cells in homeostatis

TBC1D8 NFATC2 LMO7 SYNE1

5.01e-06190274ff774faf3f12759d11e50ed7d189288bb79e22e1
ToppCellCOPD-Lymphoid|COPD / Disease state, Lineage and Cell class

RUNX2 NFATC2 SYNE1 ZC3HAV1

5.22e-06192274064fefb8212fadab0ff441f4bf643559b7fdb25d
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TBC1D8 LMO7 SYNE1 SVIL

5.33e-06193274f42a0f02ed00fe1bb833ff0a0640d9131bca89bd
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TBC1D8 LMO7 SYNE1 SVIL

5.33e-0619327442df7ed37d11fb542b4d1d714b6f87ae8e1396a6
ToppCell368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

ETV5 RPL13A SYNE1 ATAD2B

5.44e-0619427458046894446cb250814252a23f60fdd59c114d77
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m-Myeloid-neutrophil|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZFYVE26 CELSR3 SVIL

1.00e-041502736e806a028c0519489151c181d9907e05289e27e0
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

WWC2-AS2 SYNE1 HSPB8

1.17e-04158273e7db0ee4740e3c7a4d97d7cd7462e2c2ab458a4b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

WWC2-AS2 SYNE1 HSPB8

1.17e-04158273d39e020c3e77eb9d3de600a171d22f94357061d4
ToppCellfacs-Lung-24m|Lung / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PSMB8 MUC13 RPL13A

1.26e-041622734e418bea07e35038b32a78a1e6632b6ec1208cdc
ToppCellURO-Lymphocyte-T_NK-CD4_CTL|URO / Disease, Lineage and Cell Type

MSX2 NFATC2 SYNE1

1.26e-041622731afeeb17e263cf625a4f285203cf82f973735193
ToppCell343B-Epithelial_cells-Epithelial-A_(AT2)-|343B / Donor, Lineage, Cell class and subclass (all cells)

ETV5 CDKL5 LMO7

1.30e-04164273beaa13a75c3bb72446c85084d75e9fe3f15fd3d4
ToppCell343B-Epithelial_cells-Epithelial-A_(AT2)|343B / Donor, Lineage, Cell class and subclass (all cells)

ETV5 CDKL5 LMO7

1.30e-04164273d005cfd821b87548b075120bffe65a0be9860463
ToppCellSevere-Lymphoid-NK-CD8_T|Severe / Condition, Lineage, Cell class and cell subclass

RUNX2 NFATC2 SYNE1

1.38e-041672738d41015871616ab7eced5104cd8f70d0efe504f2
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PSMB8 RPL13A ZC3HAV1

1.50e-04172273f320813177f246926bfd5862b4e0f9bd828cebab
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-CD4+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PSMB8 RPL13A ZC3HAV1

1.50e-04172273b3c12a4bb08ce931de6fe800b605f3e43adea0b5
ToppCelldroplet-Kidney-KIDNEY-1m-Lymphocytic|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PSMB8 MSX2 RPL13A

1.50e-04172273adf016e5856bc85e7bed58aee09ade483b9dcb00
ToppCellAT1_cells-Donor_07|World / lung cells shred on cell class, cell subclass, sample id

WWC2-AS2 LMO7 HSPB8

1.53e-04173273b29816427428c7053017477f59b828bf1357f3b2
ToppCellMesenchymal_cells-Osteo-CAR|Mesenchymal_cells / Lineage and Cell class

PSMB8 RUNX2 LMO7

1.55e-04174273430e3cd61bc2a471959faa40e817aa4dd7d82d28
ToppCelldroplet-Marrow-nan-24m-Hematologic-hematopoietic_precursor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PSMB8 MUC13 RPL13A

1.55e-04174273955a3de6b7efc117f34c14faf8051f41454275dd
ToppCelldroplet-Pancreas-PANCREAS-30m-Hematologic-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PSMB8 RUNX2 ZC3HAV1

1.58e-04175273ca2eabf03b70353e7eb15b6f622b2f9223a99e18
ToppCelldroplet-Lung-nan-18m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBC1D8 PAN3 ABI2

1.61e-0417627324b2e94ee5defcefb64a1f2447a2cc71b015b0fd
ToppCellAT1_cells-SSc-ILD_02|World / lung cells shred on cell class, cell subclass, sample id

LMO7 HSPB8 WASF3

1.61e-041762734a30bb771297b30926fb98e2b5ec0dbdc46feac7
ToppCell(0)_Normal/No_Treatment-(3)_LEPR+_perivascular_cells|World / Stress and Cell class

RUNX2 FAM13A LMO7

1.61e-04176273ce2c32b5ce0da848eb4da35ce4d215cdf74d9113
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l34|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ETV5 MSX2 RUNX2

1.61e-0417627377c3da2eaa072a6baefb5087fd07ec18c5e271cd
ToppCelldroplet-Kidney-KIDNEY-1m-Lymphocytic-T_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MSX2 RPL13A ZC3HAV1

1.63e-0417727336da06ca9577cdb7c7b5114e604f6546b9765c08
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ETV5 FAM13A LMO7

1.69e-04179273fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RUNX2 HSPB8 SVIL

1.74e-04181273af92b8b7f455210dab502ef6964f3a0162180759
ToppCellMesenchymal_cells-Adipo-CAR|Mesenchymal_cells / Lineage and Cell class

PSMB8 FAM13A LMO7

1.74e-041812731cfb03eb03a37b036b4eeacec69c9b8163af1ee4
ToppCellControl-Epithelial_cells-Airway_club|Control / group, cell type (main and fine annotations)

FAM13A LMO7 SVIL

1.74e-04181273c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCellE18.5-samps|World / Age Group, Lineage, Cell class and subclass

FAM13A LMO7 HSPB8

1.77e-041822739649f15858d1ede73e068afc59df3ac367b49687
ToppCellCTRL-Myeloid-cDC|Myeloid / Disease state, Lineage and Cell class

RUNX2 NFATC2 WASF3

1.77e-04182273ee137574b8f0e684a4a7cb26226877c471cae433
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ETV5 FAM13A LMO7

1.77e-0418227317ed11a7ea366dd3106400511d5e628d3f1a9c3e
ToppCellHSPCs-LMPPs|HSPCs / Lineage and Cell class

PSMB8 MUC13 RUNX2

1.80e-04183273f7392645d38da7285e797aa0e4625751af83ebd7
ToppCellCOVID-19_Convalescent-Lymphoid_T/NK-CD8+_T_naive|COVID-19_Convalescent / Disease group, lineage and cell class

RUNX2 RPL13A LMO7

1.83e-041842730299cd30a3ea8e861a9d529043c204048ae21d29
ToppCellremission-CD8+_T_naive|remission / disease stage, cell group and cell class

RUNX2 RPL13A LMO7

1.83e-04184273fe20fa4457d4a4a75689978275b0afb5f6243faf
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ETV5 FAM13A LMO7

1.83e-04184273ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)

RUNX2 RPL13A LMO7

1.86e-04185273863a3d44c1f115942d7a2a2b63a92fe5fc768814
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ETV5 FAM13A LMO7

1.86e-04185273fefaf227d89f680d6f3e91c4a94e26ab4d0dc6c3
ToppCellCOVID-19_Convalescent-CD8+_T_naive|COVID-19_Convalescent / Disease condition and Cell class

RUNX2 RPL13A LMO7

1.86e-041852732f8277a0b58fb0c49fa76ff6dfa6da961da1f9f5
ToppCellremission-CD8+_T_naive|World / disease stage, cell group and cell class

RUNX2 RPL13A LMO7

1.86e-0418527369304d7dd406ac7e96d51c239d7035a06d88704f
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RUNX2 RPL13A LMO7

1.86e-0418527327dbfcd40ec832d5cf757331d8af3b5176ae90fb
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

RUNX2 RPL13A LMO7

1.86e-041852731c23891e4d75f99296d1304af7a9d6c3cb28d04c
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RUNX2 RPL13A LMO7

1.86e-04185273ca8e921a6b45cd39474b9f86c95e7be023585c5d
ToppCell(0)_MSCs-(00)_Lepr-MSC|World / Cell class and subclass of bone marrow stroma cells in homeostatis

RUNX2 FAM13A LMO7

1.89e-04186273f0d156167d7cc2cd8a76e5a364233e9f2170bc01
ToppCell(0)_MSCs|World / Cell class and subclass of bone marrow stroma cells in homeostatis

RUNX2 FAM13A LMO7

1.89e-04186273a832c1e0035bcd559722eccf262c145deb3494c7
ToppCelldroplet-Tongue-nan-24m-Epithelial-parabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MSX2 RUNX2 LMO7

1.89e-0418627318c06041c6c8a0ebac17b3c8aaebd67e652d315a
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ETV5 FAM13A LMO7

1.89e-04186273e83718fabb057100835d3357df407f283d23fe16
ToppCellControl-T_cells|Control / group, cell type (main and fine annotations)

RUNX2 NFATC2 ZC3HAV1

1.92e-04187273f4e8e0eba58da89b56587667555a5d4754e108c7
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ETV5 FAM13A LMO7

1.95e-041882734bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCellCOPD-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

NFATC2 LMO7 SYNE1

1.95e-04188273186fe1ea328c942910190a4240262c0d8642ea3b
ToppCellChildren_(3_yrs)-Immune-T_lymphocyte-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

RUNX2 NFATC2 ZC3HAV1

1.98e-04189273df30478b288084a1bd48f660409dcc784040897c
ToppCell3'-GW_trimst-1.5-LargeIntestine-Hematopoietic-Myeloid-Macrophages|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TBC1D8 CELSR3 NFATC2

1.98e-04189273b8cbfc47f3f40b6fccd15899d58c87d07b0001aa
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RUNX2 NFATC2 ZC3HAV1

2.01e-04190273b772a5d281fe016f259ddda80d6f33d949dcac2b
ToppCell(1)_Control_(PBS)-(3)_LEPR+_perivascular_cells|World / Stress and Cell class

RUNX2 FAM13A LMO7

2.01e-04190273ec0ab31266583a0966ac7615d5c0fabb7b7e66e8
ToppCelldroplet-Mammary_Gland-nan-18m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MSX2 LMO7 SVIL

2.04e-04191273c21e7904e06a5c90176f935f6822dbb5a1aa6755
ToppCellChildren_(3_yrs)-Immune-T_lymphocyte-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

RUNX2 NFATC2 ZC3HAV1

2.04e-04191273c7be771543089fc94e5c62fd22f745189642aec3
ToppCellAdult-Immune-T_lymphocyte-D175|Adult / Lineage, Cell type, age group and donor

RUNX2 NFATC2 ZC3HAV1

2.04e-041912730b84fd1dc68146d9f72422b102744d2847f5ecb2
ToppCellCOVID-19-lung-CD4+_Treg|COVID-19 / Disease (COVID-19 only), tissue and cell type

RUNX2 NFATC2 ZC3HAV1

2.04e-041912735a4ad5ae5c2dbfb225158cb598ef649c26a48350
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-T_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RUNX2 NFATC2 ZC3HAV1

2.04e-04191273326b4541069efedc8ab409f85bb11f77346dda90
ToppCell(1)_Osterolineage_cells-(10)_OLC-1|(1)_Osterolineage_cells / Cell class and subclass of bone marrow stroma cells in homeostatis

PSMB8 RUNX2 LMO7

2.04e-0419127378ad7c555409ce1391bce406bc0f3ef575329ece
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-T_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RUNX2 NFATC2 ZC3HAV1

2.04e-041912731a2d5fec2bea96da2154b0aed252f1bb35102f6e
ToppCellfacs-Skin-nan-18m-Epithelial-basal_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PSMB8 PAN3 RPL13A

2.08e-04192273be4114b88a593e8bd905108dc603f62b16c5938b
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM1_(8)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ETV5 RUNX2 RPL13A

2.08e-04192273c4efc170852abbcf0c53c2b0f8a0cc9fe7f116c8
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM1_(8)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ETV5 RUNX2 RPL13A

2.08e-041922734c9d748f209cc1e13d28c8c7f5180ab8522e0fbf
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CDKL5 FAM13A LMO7

2.08e-041922735c7e8b80b44d9ce55c797cdf8267ac5382e26cac
ToppCellLAM-Myeloid-DC|Myeloid / Condition, Lineage and Cell class

ETV5 RPL13A NFATC2

2.11e-04193273f665cce40053ae5d6e28f9f70ddf78e8598c9514
ToppCellAdult-Immune-T_lymphocyte|Adult / Lineage, Cell type, age group and donor

RUNX2 NFATC2 ZC3HAV1

2.11e-0419327326df0c4c8a2355dd5503fadd07e368eb9a2bf06a
ToppCellControl-Lymphoid-T|Control / Disease state, Lineage and Cell class

RUNX2 NFATC2 ZC3HAV1

2.11e-04193273af928046ccd1ca874be1534aef6ca7f27d90bc46
ToppCellChildren_(3_yrs)-Immune-T_lymphocyte|Children_(3_yrs) / Lineage, Cell type, age group and donor

RUNX2 NFATC2 ZC3HAV1

2.11e-04193273b9769b45125d2244afe53f9f71c92c04ddccf980
ToppCellCOVID-19-Myeloid-DC2|Myeloid / Condition, Lineage and Cell class

RUNX2 NFATC2 LMO7

2.11e-041932735f3f6db3d3de887d004662d229f42549601efa81
ToppCell356C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

ETV5 NFATC2 SYNE1

2.14e-0419427311ff53a748160570d2908ea9eb9779c038e5b676
ToppCellChildren_(3_yrs)-Immune-T_lymphocyte-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

RUNX2 NFATC2 ZC3HAV1

2.14e-041942733d6f2d190dd50804afea299957cc44c2bb756134
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LMO7 SYNE1 SVIL

2.14e-04194273e577d9e88390b36b5a09b97fe1026089892275a3
ToppCellImmune-T_lymphocyte|World / Lineage, Cell type, age group and donor

RUNX2 NFATC2 ZC3HAV1

2.14e-04194273f47fa18c87b35a3960557f8169ff7830dd6ecb80
ToppCellDiffer-Basal|World / shred by cell class for mouse tongue

MSX2 RUNX2 LMO7

2.14e-04194273851eff82c9f3d44c86e3e127a804bbd1fced6a7c
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ETV5 CDKL5 LMO7

2.17e-04195273d9694db6bf239636d1335016878c98f6ee2eb0eb
ToppCell367C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ETV5 NFATC2 SYNE1

2.17e-041952734008fa86b5166087a4b20f89ae07e1dfc87c855d
ToppCell(3)_MNP-(3)_Macrophage_MARCOneg|(3)_MNP / Lung cell shreds - cell class (v4) and cell subclass (v4)

ETV5 NFATC2 SYNE1

2.17e-04195273e4b5e4b8832669fb4d1661ecd828b81e621d35c4
ToppCell343B-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

ETV5 NFATC2 SYNE1

2.17e-0419527367b05a0cd2ca9924eca81a92cc6330eecb9d963c
ToppCell3'-Parenchyma_lung-Epithelial|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ETV5 LMO7 SYNE1

2.17e-04195273eec187c087e432417bc346c5d3ead72f58bf3215
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RPL13A NFATC2 SYNE1

2.20e-041962730f3c7fd450aaa1f866b8558692534c0ea2a34e75
ToppCellhealthy_donor-Lymphocytic-T_cell-CD8+_Memory_T_cell|healthy_donor / Disease condition, Lineage, Cell class and subclass

RPL13A NFATC2 SYNE1

2.20e-04196273af00c31612e4fe068e5fccae05368edba46bbd20
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

RPL13A NFATC2 SYNE1

2.20e-041962734e1f8828413896ab8a4ec92a89d6789e8e37e05a
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway-secretory_cell|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

FAM13A HSPB8 ATAD2B

2.20e-04196273547901c7a665770eff78eede69b8625b416c8186
ToppCelldroplet-Tongue-nan-3m-Epithelial-parabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MSX2 RUNX2 LMO7

2.20e-04196273159061fd0961b2cfb5941d403acc5b395dd0d3a0
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

FAM13A HSPB8 ATAD2B

2.20e-041962736e08d7ba67da161c2dca1a17c440ffb9d9b5bc3b
ToppCell367C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

ETV5 NFATC2 SYNE1

2.20e-04196273e8c4eeb4b6c6d9bccca2adb942d4cfbaab39636c
ToppCellLPS_IL1RA_TNF|World / Treatment groups by lineage, cell group, cell type

FAM13A LMO7 SYNE1

2.24e-041972730a6550dce156fc81f15b1e7830d331ca50d87d06
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

WWC2-AS2 NFATC2 SYNE1

2.24e-04197273f84263c5aaf3a5cd46d6e06358e8de6c6e6eaa3b
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_Tem|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

RPL13A NFATC2 SYNE1

2.24e-041972732b3a56bb1d40bc1284a5931c4e7b373660de5402
ToppCellCOVID-19_Severe-Lymphoid_T/NK-CD8+_Tem|COVID-19_Severe / Disease group, lineage and cell class

RPL13A NFATC2 SYNE1

2.24e-04197273f0bac4d5c3160933ac3786cec8dadffb35d711ea
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / Treatment groups by lineage, cell group, cell type

ETV5 FAM13A LMO7

2.24e-041972731a1bee8da6e04b65935c40373eaee4d6c046d9a1
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_Tem-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

RPL13A NFATC2 SYNE1

2.24e-04197273f73ece3aca28c0db5db0f12e026d42c6c36b9efb
ToppCellcontrol-Lymphocytic-CD8_T_cells|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

RPL13A NFATC2 SYNE1

2.24e-04197273c1c47db5e8d1b248bc192556275edd1ce168a953
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_Tem-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RPL13A NFATC2 SYNE1

2.24e-04197273bce0135a96910d2bace62a3408a1a6fdac0cf0df
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_Tem|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RPL13A NFATC2 SYNE1

2.24e-04197273e70e7d97823a762def3970d94a0e897981a6c922
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ETV5 FAM13A LMO7

2.24e-041972731485933986921ff45669d9b7501c8d17050b3e97
ToppCellCOVID_vent-Lymphocytic-T_cell|COVID_vent / Disease condition, Lineage, Cell class and subclass

RPL13A SYNE1 ZC3HAV1

2.24e-04197273ad702e440a74d54cfdcb8bb1c66bd8e0e71ab04e
Drugpotassium phosphate

MSX2 RUNX2

3.76e-063262ctd:C013216
Drugbeta-glycerophosphoric acid

MSX2 RUNX2 ATAD2B

6.03e-0567263ctd:C031463
DrugLY 294002; Up 200; 10uM; PC3; HT_HG-U133A

TBC1D8 CELSR3 SYNE1 SVIL

6.21e-051912641227_UP
DrugOxyphenbutazone [129-20-4]; Up 200; 12.4uM; PC3; HT_HG-U133A

MSX2 RUNX2 HSPB8 ATAD2B

6.60e-051942644506_UP
DrugPOCl3

MSX2 SYNE1

6.85e-0511262CID000024813
DrugGabazine [105538-73-6]; Down 200; 10.8uM; HL60; HT_HG-U133A

ETV5 ZFYVE26 FAM13A SVIL

7.14e-051982641316_DN
DrugPentoxifylline [6493-05-6]; Down 200; 14.4uM; PC3; HT_HG-U133A

ETV5 MSX2 FAM13A SVIL

7.28e-051992642127_DN
Drugclozapine; Down 200; 10uM; MCF7; HG-U133A

ZFYVE26 FAM13A ABI2 SVIL

7.42e-05200264416_DN
DiseaseCraniosynostosis

MSX2 RUNX2

1.52e-0420272C0010278
Diseaseprogressive supranuclear palsy

TBC1D8 RUNX2

3.69e-0431272MONDO_0019037
Diseaseplatelet component distribution width

ETV5 SYNE1 ATAD2B SVIL WASF3

5.47e-04755275EFO_0007984
Diseasesitting height ratio

NFATC2 ATAD2B

1.00e-0351272EFO_0007118
Diseaseglucose metabolism measurement, age-related hearing impairment

ZNF469 NFATC2

1.04e-0352272EFO_0005782, EFO_0009367
Diseaseintraocular pressure measurement

TBC1D8 ZNF469 RUNX2 LMO7

1.12e-03509274EFO_0004695
Diseasemyeloid white cell count

TBC1D8 RUNX2 FAM13A ATAD2B ZC3HAV1

1.44e-03937275EFO_0007988
Diseasecreatinine measurement

TBC1D8 ETV5 CDKL5 CELSR3 SVIL

1.88e-03995275EFO_0004518
Diseasefeeling "fed-up" measurement

ABI2 ATAD2B

2.20e-0376272EFO_0009588
Diseasehair colour measurement

MSX2 ZNF469 RUNX2 FAM13A

2.24e-03615274EFO_0007822
Diseasereticulocyte measurement

TBC1D8 ZNF469 ATAD2B EIF4G1 ZC3HAV1

2.41e-031053275EFO_0010700
DiseaseColorectal Carcinoma

CDKL5 LMO7 SYNE1 EIF4G1

3.61e-03702274C0009402

Protein segments in the cluster

PeptideGeneStartEntry
YSMNRPASRHTPPTI

ABI2

351

Q9NYB9
RRSDPGHYSFSMRSP

PSMB8

26

P28062
HYSPRTSPIMSPRTS

NFATC2

211

Q13469
MSPYHQPTSYRPRLL

ATAD2B

756

Q9ULI0
MPFSCHYPSRLRRDP

HSPB8

6

Q9UJY1
MTYPPHRAFSRSDVP

IBA57-DT

1

B1ANH7
RAYMRNPSSSVPPPS

LMO7

1556

Q8WWI1
PGDNRPSYHRQMSEP

ETV5

236

P41161
RPHRPRGPIMALYSS

ODF3

11

Q96PU9
PPSPPNSHSFMRRRS

FAM13A

636

O94988
APRRRSHTPNPASYM

PAN3

356

Q58A45
MNTPSQPRQHFYPSR

EIF4G1

41

Q04637
MEHPSSPRGARRYPR

CELSR3

2331

Q9NYQ7
PNGHPYNRTNRSRMP

CDKL5

936

O76039
RYSPPPRHMSPTTCT

MSX2

121

P35548
SLTESRFSNPRMHYP

RUNX2

381

Q13950
RYMRASDPASPHIGR

SVIL

41

O95425
ARSFHPMLRYTNGPP

SYNE1

8781

Q8NF91
PRVSHRMQPRGSFYS

ANKHD1

2131

Q8IWZ3
QMQNPYSRHSSMPRP

MUC13

496

Q9H3R2
RMNTNPSRGPYHFRA

RPL13A

61

P40429
QPRPMASRHDPSRPY

TBC1D8

836

O95759
YRPPSASARHMALNR

WASF3

286

Q9UPY6
PDRMPRGHSSYSPSN

ZNF469

2291

Q96JG9
PRAPSSHRRNMAYRA

ZC3HAV1

231

Q7Z2W4
SSPFRPAARPRMSPH

WWC2-AS2

66

Q96NR7
EQPSRRYQPATRHPS

ZFYVE26

751

Q68DK2
SASMPYKRRRSTPAP

UBR5

626

O95071