Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiondisordered domain specific binding

SMTNL1 FYN CREBBP

3.61e-0539333GO:0097718
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

RYR2 ITPR1

3.99e-0418332GO:0015278
GeneOntologyMolecularFunctionligand-gated calcium channel activity

RYR2 ITPR1

1.20e-0331332GO:0099604
GeneOntologyMolecularFunctioncalcium channel activity

CACNA2D4 RYR2 ITPR1

1.25e-03129333GO:0005262
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

RYR2 ITPR1

1.35e-0333332GO:0005217
MousePhenoenhanced avoidance learning behavior

UBR1 FYN

3.85e-055282MP:0012313
MousePhenoenhanced passive avoidance behavior

UBR1 FYN

3.85e-055282MP:0003999
DomainSpectrin_repeat

MACF1 SYNE3 PPL

1.62e-0529323IPR002017
DomainSpectrin/alpha-actinin

MACF1 SYNE3 PPL

2.19e-0532323IPR018159
DomainSPEC

MACF1 SYNE3 PPL

2.19e-0532323SM00150
DomainRIH_assoc

RYR2 ITPR1

4.25e-056322PF08454
DomainRIH_assoc-dom

RYR2 ITPR1

4.25e-056322IPR013662
DomainRIH_dom

RYR2 ITPR1

4.25e-056322IPR000699
DomainIns145_P3_rcpt

RYR2 ITPR1

4.25e-056322IPR014821
DomainRyanodine_recept-rel

RYR2 ITPR1

4.25e-056322IPR015925
Domain-

RYR2 ITPR1

4.25e-0563221.25.10.30
DomainRYDR_ITPR

RYR2 ITPR1

4.25e-056322PF01365
DomainIns145_P3_rec

RYR2 ITPR1

4.25e-056322PF08709
DomainPlectin_repeat

MACF1 PPL

5.94e-057322IPR001101
DomainPlectin

MACF1 PPL

5.94e-057322PF00681
DomainPLEC

MACF1 PPL

5.94e-057322SM00250
DomainMIR

RYR2 ITPR1

1.27e-0410322PS50919
DomainMIR

RYR2 ITPR1

1.27e-0410322PF02815
DomainMIR

RYR2 ITPR1

1.27e-0410322SM00472
DomainMIR_motif

RYR2 ITPR1

1.27e-0410322IPR016093
DomainSpectrin

MACF1 SYNE3

7.04e-0423322PF00435
DomainQuinoprotein_ADH-like_supfam

DMXL2 WDR75

3.71e-0353322IPR011047
DomainSH3

MACF1 SH3TC2 FYN

5.91e-03216323PS50002
DomainSH3_domain

MACF1 SH3TC2 FYN

6.22e-03220323IPR001452
Pubmed

Regulation of the type 1 inositol 1,4,5-trisphosphate receptor by phosphorylation at tyrosine 353.

FYN ITPR1

8.73e-07233214761954
Pubmed

Fyn can partially substitute for Lck in T lymphocyte development.

RAG1 FYN

2.62e-0633328934569
Pubmed

Dysregulated ryanodine receptors mediate cellular toxicity: restoration of normal phenotype by FKBP12.6.

RYR2 ITPR1

2.62e-06333212754204
Pubmed

Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors.

FYN ITPR1

2.62e-06333228598420
Pubmed

Intracellular calcium release channel expression during embryogenesis.

RYR2 ITPR1

2.62e-0633329986730
Pubmed

Ryanodine receptor calcium release channels: lessons from structure-function studies.

RYR2 ITPR1

5.23e-06433223413940
Pubmed

Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.

RYR2 ITPR1

5.23e-0643329607712
Pubmed

Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.

RYR2 ITPR1

5.23e-06433219120137
Pubmed

Intracellular calcium-release channels: regulators of cell life and death.

RYR2 ITPR1

8.72e-0653329124414
Pubmed

Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.

RYR2 ITPR1

1.31e-05633223463619
Pubmed

A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.

RYR2 ITPR1

1.31e-05633220519450
Pubmed

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.

RYR2 ITPR1

1.31e-05633225966694
Pubmed

IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.

RYR2 ITPR1

1.31e-05633216844763
Pubmed

Functional proteomics mapping of a human signaling pathway.

MACF1 CHD6 CDC123 CREBBP PPL RYR2

1.76e-0559133615231748
Pubmed

Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.

RYR2 ITPR1

1.83e-05733211860456
Pubmed

Twist1 transcriptional targets in the developing atrio-ventricular canal of the mouse.

ADAMTS19 WDR75

4.78e-051133222815831
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

MACF1 ALS2 DMXL2 CHD6

6.02e-0522533412168954
Pubmed

E protein silencing by the leukemogenic AML1-ETO fusion protein.

CREBBP CBFA2T2

7.89e-051433215333839
Pubmed

Identification of RanBP 9/10 as interacting partners for protein kinase C (PKC) gamma/delta and the D1 dopamine receptor: regulation of PKC-mediated receptor phosphorylation.

MACF1 ITPR1

1.18e-041733220395553
Pubmed

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

CHD6 CREBBP

3.02e-042733217525332
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

CHD6 WDR75 CREBBP RYR2 TM9SF3

3.17e-0463833531182584
Pubmed

Endoplasmic reticulum resident protein 44 (ERp44) deficiency in mice and zebrafish leads to cardiac developmental and functional defects.

RYR2 ITPR1

3.25e-042833225332179
Pubmed

Gene expression in the developing mouse retina by EST sequencing and microarray analysis.

DGKH RYR2 TM9SF3

3.32e-0414233311812828
Pubmed

Modelling thymic HIV-1 Nef effects.

FYN ITPR1

3.74e-043033216454711
Pubmed

Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.

ANKRD31 MACF1 FBXL13

4.06e-0415233334299191
Pubmed

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

RAG1 FBXL13 RHOBTB1 FYN

4.12e-0437233422939624
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

RYR2 ITPR1

6.01e-043833230786075
Pubmed

A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

ZMIZ1 RHOBTB1 CDC123 TM9SF3

6.22e-0441533416385451
Pubmed

Roles of tau protein in health and disease.

FYN CREBBP

6.66e-044033228386764
Pubmed

Bioinformatics and cellular signaling.

ZMIZ1 FYN RYR2

6.85e-0418233315102471
Pubmed

Aire's partners in the molecular control of immunological tolerance.

RAG1 CHD6

8.43e-044533220085707
Pubmed

Huntingtin interacting proteins are genetic modifiers of neurodegeneration.

CREBBP PPL ITPR1

8.62e-0419733317500595
Pubmed

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.

MACF1 CREBBP RYR2

8.62e-0419733320811636
GeneFamilyEF-hand domain containing|Plakins

MACF1 PPL

6.91e-058292939
CoexpressionGSE39556_UNTREATED_VS_3H_POLYIC_INJ_MOUSE_CD8A_DC_DN

RAG1 DMXL2 ZMIZ1 FYN ITPR1

4.91e-06200335M9408
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Fibroblasts|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANKRD31 ADAMTS19 LOXL3 ITPR1

5.40e-06157334f086753b51860e23f1275bd75e8802d2a7d7b70a
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

UBR1 DMXL2 DGKH CACNA2D4

8.10e-0617433458300d64d3b6fd9ba1b6c87ea83b2777eb6be2f4
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-early_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAG1 SH3TC2 CACNA2D4 RHOBTB1

8.47e-0617633488ca2f83d8301633232735f39b0683efe49d0b86
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-early_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAG1 SH3TC2 CACNA2D4 RHOBTB1

8.47e-061763347292e014b8f697f0c2e9f47c48333de95cb44a69
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

UBR1 MACF1 SFI1 SYNE3

1.17e-051913349454f642c3621370fa23640b631301346b300950
ToppCellLPS-IL1RA-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MACF1 DGKH RXFP1 FYN

1.24e-051943340b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

MACF1 DGKH FYN

1.74e-0414733394998bc40f5c08295cfe3bdcbe43f13b1e564b3d
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_1|368C / Donor, Lineage, Cell class and subclass (all cells)

UBR1 DGKH CACNA2D4

1.77e-0414833380470353e12599440f711b6e107730763376d04d
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma-4|TCGA-Brain / Sample_Type by Project: Shred V9

RXFP1 RYR2 ITPR1

1.81e-04149333ff472ad641efd655905e99a9a4cacd5245ab8854
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8|bone_marrow / Manually curated celltypes from each tissue

MACF1 DGKH FYN

2.07e-041563331545169694f686d28648a68b552c2ae606599d66
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS19 ATP13A5 RYR2

2.23e-04160333c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS19 ATP13A5 RYR2

2.23e-0416033325c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8|blood / Manually curated celltypes from each tissue

MACF1 SFI1 ITPR1

2.31e-04162333b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCelldroplet-Lung-LUNG-1m-Myeloid-plasmacytoid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBXL13 FYN ITPR1

2.48e-041663336e6075d0c913e2516083f6dcab21d5878bcef7a4
ToppCelldroplet-Lung-1m-Hematologic-myeloid-plasmacytoid_dendritic_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBXL13 FYN ITPR1

2.48e-041663331ca888ae8168707493f19ee52a89d7c70e6cb51d
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_KRT17|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANKRD31 DGKH RXFP1

2.48e-04166333739dfbe927f409821ff23aca6e47ebe78f57e859
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Plasmacytoid_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBXL13 FYN ITPR1

2.48e-041663334fbe44e0aea197893614cd55f83119aa0f73ee53
ToppCelldroplet-Lung-1m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBXL13 FYN ITPR1

2.48e-041663334cba4ca1aa2321b9ef7cd230932b890d2434a252
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANKRD31 DGKH RXFP1

2.52e-04167333a6ff7a3d9b80839c0efa91658836812e868561fa
ToppCellMild/Remission-B_naive-4|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

MACF1 CREBBP ITPR1

2.61e-04169333c3a6179a64589a370108fea809b157839347759c
ToppCell10x5'v1-week_17-19-Hematopoietic-HSC/MPP_and_pro-ELP|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

RAG1 TM9SF3 ITPR1

2.66e-04170333a50e558d0b38100ccbdccb90647fe93e85bffd86
ToppCellfacs-Marrow-T-cells-3m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBXL13 FYN ITPR1

2.71e-041713336a0fafb8fd9fc7671618eeb2bf528ce8ce86b794
ToppCellfacs-Marrow-T-cells-3m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBXL13 FYN ITPR1

2.71e-04171333e02b5831768dbb1b68998b672e55c9680ab0cc86
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_KRT17|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANKRD31 DGKH RXFP1

2.75e-04172333adc09c4d1b63fe84150516beb692db1e7f7ac980
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_1|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

UBR1 DMXL2 DGKH

2.80e-04173333efb8072475000888efe088d00e870c56ffad4172
ToppCell(6)_Endothelial_cells-(6)_Endothelial-E|(6)_Endothelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

DGKH RXFP1 FYN

2.85e-041743334a1b67ce5ea353b3f81f59fa57da07668146afca
ToppCell10x5'-blood-Lymphocytic_T_CD4-Tfh|blood / Manually curated celltypes from each tissue

DGKH PARG ITPR1

2.90e-04175333d7e24ac683ff36f7ce3d1151353d3d4a6f2b63bf
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MACF1 RYR2 PARG

2.95e-04176333749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SFI1 FYN ITPR1

2.99e-041773339edfb50856f5e10672ab194ce0076d6a190e64de
ToppCellnucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DGKH MUC4 PPL

2.99e-04177333cbad1a23851151dbef01ea2af960e6f0944f838b
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBXL13 FYN ITPR1

3.09e-0417933387a69f9f83b8f0c028a4874acb238f2e079bf51f
ToppCelldroplet-Marrow-nan-3m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBXL13 FYN ITPR1

3.09e-04179333dcaf2191134a586d50ebaf67dcf5b815b54a722b
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MACF1 DGKH MUC4

3.09e-041793336e965e424eebef50f0202cff75f458be395cfca1
ToppCellfacs-Marrow-B-cells-3m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBXL13 FYN ITPR1

3.15e-04180333bf8d13d4db1af55b8c9fe16aaccf8743e000e005
ToppCellfacs-Marrow-B-cells-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBXL13 FYN ITPR1

3.15e-04180333839defb40f7cfb2711e9025194de636533f51bcd
ToppCellfacs-Marrow-B-cells-3m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBXL13 FYN ITPR1

3.15e-0418033382965ed1b72a1873c24dd4553d39681596057316
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBXL13 FYN ITPR1

3.15e-04180333df60970520fba2ac0639faa54096766d07418ca4
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-M/X_cells_(MLN/GHRL+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DGKH TAS2R9 PPL

3.20e-04181333cb17c904ab86d56dd30cac9b61acbb3b76f84ded
ToppCellCOPD-Epithelial-Basal|World / Disease state, Lineage and Cell class

DGKH MUC4 PPL

3.20e-041813336d8a886b4afe729f8a05b9c0f4ea9375de735da4
ToppCell10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8|Liver / Manually curated celltypes from each tissue

MACF1 DGKH SFI1

3.20e-04181333f2315414e714ac86211546a935660c4be6e85f1b
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADAMTS19 DGKH RYR2

3.30e-041833338a799807fbf24456a9811e0c64068187940a2f71
ToppCellCOPD-Epithelial-Basal|COPD / Disease state, Lineage and Cell class

DGKH MUC4 PPL

3.30e-041833330f760e393edc91009bf6c7e02eeac039a1dfb4ed
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DGKH SFI1 FYN

3.35e-04184333bd786db4dc4edae6d5cfc0b69901983dea19f729
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

MACF1 DMXL2 SFI1

3.41e-04185333a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RXFP1 RYR2 ITPR1

3.46e-0418633384ba666237c18189d7e7556bd92dd953af733c00
ToppCellCV-Moderate-7|CV / Virus stimulation, Condition and Cluster

MACF1 DMXL2 SFI1

3.46e-041863338571956890fc9894d766ba294a28e376b4aba428
ToppCell343B-Endothelial_cells-Endothelial-E|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

DGKH RXFP1 FYN

3.46e-04186333080e56113b89138277a2bd2eabddfa6cd1a18b61
ToppCell343B-Endothelial_cells-Endothelial-E-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

DGKH RXFP1 FYN

3.46e-04186333dae6a98963c78bf7518ebab8dc02f173c3b0f7f7
ToppCellpdx-Tumor_cells-T5|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

ADAMTS19 FYN ITPR1

3.52e-041873337e376831a11ee72ed87abcdac631ca46ae29c250
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

MACF1 DGKH ITPR1

3.57e-04188333ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell-Unknown-Endothelial-Myofibroblast| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DGKH WDR75 RYR2

3.57e-041883336468fa95ad0395395301115286f2d8c0df5d3882
ToppCell10x5'v1-week_17-19-Lymphocytic_B-B_lineage-pre_pro_B_progenitor|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

RAG1 SYNE3 ZMIZ1

3.57e-041883339858940c616e43441644c5a3bea8d832ee4daf79
ToppCell-Unknown-Endothelial| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DGKH WDR75 RYR2

3.57e-041883337a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCellLA-13._Vascular_Smooth_Muscle|LA / Chamber and Cluster_Paper

MACF1 RYR2 ITPR1

3.57e-0418833334e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell-Unknown| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DGKH WDR75 RYR2

3.57e-041883339cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCellhuman_hepatoblastoma-Tumor_cells-T5|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

ADAMTS19 FYN ITPR1

3.57e-04188333b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCellT_cells-GZMK+_CD8+_T_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

MACF1 DGKH FYN

3.63e-04189333e2ca075aedf7c370ab4ede6272254ffd06cbcdec
ToppCellControl-Endothelial-VE_Capillary_B|Endothelial / Disease state, Lineage and Cell class

DGKH RXFP1 FYN

3.68e-041903337f3f419fffe02934b6f27b697f7a6401072491ed
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RXFP1 RYR2 ITPR1

3.68e-0419033349e09cdb843b3d889a06a811aa5affae68b25a75
ToppCell10x3'2.3-week_17-19-Lymphocytic_B-B_lineage-pro_B_progenitor|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

RAG1 ZMIZ1 ITPR1

3.74e-0419133340813c397f533c2f4a6359a77757f736b6d9e07d
ToppCellB_cell_maturation-CD34+_pre-plamsa|B_cell_maturation / Lineage and Cell class

RAG1 SYNE3 ZMIZ1

3.74e-041913334ee160a863d4fb9c4c9449633b9f337db8871992
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

MACF1 DGKH FYN

3.80e-041923338b86db2ebe0199fee0e9800566a619a24bfdeed5
ToppCellhuman_hepatoblastoma-Tumor_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

ADAMTS19 CHD6 CBFA2T2

3.80e-04192333916fbec1c7ab7969bda711886ac88e877e30c280
ToppCellfacs-Aorta-Heart-3m|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MACF1 SFI1 ZMIZ1

3.80e-041923331ccc47792edf9ee23501c8e2165d11271636b66a
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

MACF1 SFI1 FYN

3.80e-0419233347646d7e4990be85072987f92bf18d52f8da752e
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RXFP1 RYR2 ITPR1

3.80e-041923335c7e8b80b44d9ce55c797cdf8267ac5382e26cac
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DGKH RXFP1 FYN

3.86e-04193333e09387af84d2a0a526e54d4793e6e06c6739db53
ToppCellControl-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

MACF1 RYR2 ITPR1

3.86e-041933335896242f713ae5fd1a4ebb63827f15d7279dced2
ToppCellLPS-antiTNF-Endothelial-Endothelial-Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DGKH RXFP1 FYN

3.86e-041933336e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCellfacs-Skin-Anagen-3m-Epithelial-bulge_keratinocyte|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS19 MACF1 ZMIZ1

3.86e-04193333eba3c70701b051bc1ed1f4db9270cb27a77ffc3e
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DGKH RXFP1 FYN

3.86e-04193333ad3f4fcc8e2816d696cbcde744dc16500e51ccac
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

MACF1 DGKH SFI1

3.86e-041933339337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

DGKH RXFP1 FYN

3.92e-0419433368004855b23fe1e31e8452d70effabc78a4a0bd3
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-NK-NK-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MACF1 DGKH FYN

3.92e-041943333211d89440a6f4a9b3d4cfb755890816944242ec
ToppCellfacs-Skin-Anagen-3m-Epithelial-outer_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS19 MACF1 ZMIZ1

3.92e-041943335d30d3d41d5f19cdf3077cc609aa2738762cb8c5
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DGKH SFI1 FYN

3.92e-04194333a44be2f021cfdd0fcdc698c3f04d66db7a1aa6c2
ToppCellIPF-Endothelial-VE_Capillary_B|Endothelial / Disease state, Lineage and Cell class

DGKH RXFP1 FYN

4.03e-041963338f0f72ead06abe02b575e443552eacc2151077ef
ToppCellEndothelial-capillary_endothelial_cell_(Cap1)|World / Lineage, Cell type, age group and donor

DGKH RXFP1 FYN

4.03e-041963330ce3ed27d2b9276390952652c17a8d6de13add36
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

MACF1 CBFA2T2 RYR2

4.09e-04197333fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCellT_cells-Treg_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

DGKH SFI1 FYN

4.09e-04197333de5448fcdf4e433fc167496413abe5d0c8a5c6d8
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC4 PPL TM9SF3

4.09e-04197333adb4e27d73ae2e6a39d212c0ead3ac0ad62d9131
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC4 PPL TM9SF3

4.22e-041993331e693d7bb481bf03a943b460a69787229625d7b1
ToppCellTracheal-NucSeq-Immune_Lymphocytic-T-T_CD3-NKT|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SMTNL1 CACNA2D4 FYN

4.22e-04199333d3dc52e1f0040763888f951a7c047db4a329a653
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC4 PPL TM9SF3

4.22e-041993338bf8d7cd774479f065bbbbcb5a4bd1aa91aa0d85
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP13A5 PPL TM9SF3

4.22e-041993336977f939ddbc47d4921f36c0a61a205259fe1284
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC4 PPL TM9SF3

4.22e-041993330c060ef64341659f4b1247d0264ac12e53a7e12e
ToppCellTracheal-NucSeq-Immune_Lymphocytic-T-T_CD3|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SMTNL1 CACNA2D4 FYN

4.22e-041993334be4527f351b701438a8bcb738229a06dbf8bc96
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP13A5 PPL TM9SF3

4.22e-04199333fbd39d34636137d1b877dd8815d58f124990136b
ToppCellNeuronal-Excitatory-eE(FEZF2_SLC17A7)|Neuronal / cells hierarchy compared to all cells using T-Statistic

ANKRD31 DGKH RXFP1

4.28e-04200333501cd2b4e55444fc5fdd93ebbcfc0616442b110b
ToppCellcontrol-Epithelial|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DGKH MUC4 PPL

4.28e-04200333f95bbb94e51ac28b1995026c599ec3a34e012916
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

MACF1 DGKH FYN

4.28e-04200333dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Gen_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

MACF1 DGKH FYN

4.28e-04200333a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC4 PPL TM9SF3

4.28e-04200333b68d212159b9d04866ba02ff55c35be247805eec
ToppCellcontrol|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DGKH MUC4 PPL

4.28e-0420033397f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCellNeuronal-Excitatory-eE(FEZF2_SLC17A7)-eE_1(EFTUD1P1)---L5-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

ANKRD31 DGKH RXFP1

4.28e-04200333046a3a4d7e4d84ee4252a695ffd4a6aee8b77070
ToppCellNeuronal-Excitatory-eE(FEZF2_SLC17A7)-eE_1(EFTUD1P1)-|Neuronal / cells hierarchy compared to all cells using T-Statistic

ANKRD31 DGKH RXFP1

4.28e-04200333893cc7f6b9794da90aa0c9d721b8647dc97201cd
ToppCellNeuronal-Excitatory-eE(FEZF2_SLC17A7)-eE_1(EFTUD1P1)|Neuronal / cells hierarchy compared to all cells using T-Statistic

ANKRD31 DGKH RXFP1

4.28e-042003333d677f13e429abc805a52ec2b8f36c703f511569
ToppCellNS-control-d_0-4-Epithelial|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DGKH MUC4 PPL

4.28e-04200333d014959891893b6d3854a471fba1dc50c6625a0a
ToppCellNeuronal-Excitatory|Neuronal / cells hierarchy compared to all cells using T-Statistic

RXFP1 RYR2 ITPR1

4.28e-042003334409065bc7aa995354c71e0f9d6f3726cf393d6b
ToppCell5'-Airway_Nasal|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC4 PPL TM9SF3

4.28e-04200333f6e967738b4f7b173d6e9977e305f77380dd6c8a
DrugN-cyclopentyl-N-cyclobutylformamide

CACNA2D4 CBFA2T2 RYR2 ITPR1

5.09e-0679334CID005287890
Drugmanidipine

CACNA2D4 CBFA2T2 RYR2 ITPR1

1.06e-0595334CID000004008
DrugCyclic ADP-Ribose

RYR2 PARG

1.22e-054332ctd:D036563
DrugCNS 1145

CACNA2D4 RYR2 ITPR1

1.47e-0533333CID000190902
DrugIHC-64

CACNA2D4 RYR2 ITPR1

1.47e-0533333CID000162753
Druglamotrigine

CACNA2D4 LOXL3 RYR2 ITPR1

2.34e-05116334CID000003878
Drug[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate

RYR2 ITPR1

4.26e-057332CID009547999
DrugBr2BAPTA

RYR2 ITPR1

4.26e-057332CID003081001
DrugCinildipine

CACNA2D4 RYR2 ITPR1

7.30e-0556333CID000002752
Drugnilvadipine

CACNA2D4 RYR2 ITPR1

8.97e-0560333CID000004494
DrugPCB 95

RYR2 ITPR1

9.10e-0510332CID000038012
DrugIAA-94

CACNA2D4 RYR2 ITPR1

9.43e-0561333CID000003667
Druglercanidipine

CACNA2D4 RYR2 ITPR1

1.04e-0463333CID000065866
Druglavendustin A

CACNA2D4 FYN RYR2 ITPR1

1.06e-04171334CID000003894
DrugR 478

RYR2 ITPR1

1.11e-0411332CID000084223
Drug8-amino-cADPR

RYR2 ITPR1

1.11e-0411332CID003081323
Druggallopamil

CACNA2D4 RYR2 ITPR1

1.25e-0467333CID000001234
DrugAC1L2AC7

CACNA2D4 RYR2 ITPR1

1.36e-0469333CID000068733
DrugIpratropium bromide [22254-24-6]; Down 200; 9.8uM; HL60; HG-U133A

DMXL2 CREBBP TM9SF3 ITPR1

1.56e-041893341769_DN
DrugCAS 298-57-7

CACNA2D4 RYR2 ITPR1

1.61e-0473333CID000002761
Drugethosuximide

CACNA2D4 RYR2 ITPR1

1.68e-0474333CID000003291
DrugEthynylestradiol 3-methyl ether [72-33-3]; Up 200; 12.8uM; MCF7; HT_HG-U133A

DMXL2 SFI1 FYN ITPR1

1.76e-041953343346_UP
DrugDobutamine hydrochloride [49745-95-1]; Down 200; 11.8uM; PC3; HT_HG-U133A

SH3TC2 SFI1 RHOBTB1 FYN

1.79e-041963346286_DN
DrugTrimipramine maleate salt [521-78-8]; Up 200; 9.8uM; MCF7; HT_HG-U133A

DMXL2 SFI1 CREBBP ITPR1

1.86e-041983343342_UP
DrugAdrenosterone [382-45-6]; Up 200; 13.4uM; MCF7; HT_HG-U133A

MUC4 CREBBP RYR2 ITPR1

1.86e-041983345464_UP
DrugPepstatin A [26305-03-3]; Up 200; 5.8uM; MCF7; HT_HG-U133A

MACF1 SFI1 CBFA2T2 ITPR1

1.90e-041993343264_UP
DrugThyroxine (L) [51-48-9]; Up 200; 5.2uM; MCF7; HT_HG-U133A

RAG1 SFI1 CBFA2T2 RYR2

1.90e-041993343249_UP
Drugnisoldipine

CACNA2D4 RYR2 ITPR1

1.96e-0478333CID000004499
DrugFura-2AM

CACNA2D4 RYR2 ITPR1

2.04e-0479333CID000105091
DrugFPL 64176

CACNA2D4 RYR2

2.11e-0415332CID000003423
DrugGvapspat amide

RYR2 ITPR1

2.11e-0415332CID000125015
Drugplakin

MACF1 SYNE3 PPL

2.27e-0482333CID000018752
DiseaseProstatic Neoplasms

RAG1 CHD6 MUC4 CREBBP PPL ITPR1

5.54e-05616336C0033578
DiseaseMalignant neoplasm of prostate

RAG1 CHD6 MUC4 CREBBP PPL ITPR1

5.54e-05616336C0376358
DiseasePR interval

MACF1 CHD6 SYNE3 ZMIZ1 RYR2

2.10e-04495335EFO_0004462
Diseasecomplex trait

ANKRD31 MACF1 DMXL2 CHD6

2.31e-04271334EFO_0010578
Diseaseamyotrophic lateral sclerosis (implicated_via_orthology)

ATP13A5 ALS2

5.17e-0430332DOID:332 (implicated_via_orthology)
Diseaseurate measurement, bone density

RHOBTB1 PPL PARG TM9SF3 ITPR1

5.83e-04619335EFO_0003923, EFO_0004531
Diseaseautism spectrum disorder (implicated_via_orthology)

CHD6 WDR75 CREBBP

6.53e-04152333DOID:0060041 (implicated_via_orthology)
Diseasepulmonary function measurement, forced expiratory volume

DGKH CDC123

7.88e-0437332EFO_0003892, EFO_0004314
DiseaseCarcinoma, Transitional Cell

CHD6 CREBBP

9.68e-0441332C0007138
DiseaseHuntington's disease (is_marker_for)

SYNE3 CREBBP

1.61e-0353332DOID:12858 (is_marker_for)
Diseasevascular endothelial growth factor measurement

ATP13A5 DGKH

1.80e-0356332EFO_0004762
DiseaseC-reactive protein measurement

MACF1 DMXL2 DGKH ZMIZ1 PPL ITPR1

1.98e-031206336EFO_0004458
Diseasepsoriasis vulgaris

ZMIZ1 FYN

2.13e-0361332EFO_1001494

Protein segments in the cluster

PeptideGeneStartEntry
TMPWKCHSLEDYRKH

ATP13A5

331

Q4VNC0
KEDHYVGHWKEGKMC

ALS2

1096

Q96Q42
NCYNTKSHAHKMVKW

CREBBP

1731

Q92793
CEMHVYAQWKHAVKF

DMXL2

1266

Q8TDJ6
QSKCYEMEDVLKHHW

RAG1

981

P15918
HHGEKMLESFCKWQH

ADAMTS19

391

Q8TE59
HIMDQHWKFCVECEE

ANKRD31

1856

Q8N7Z5
IYTAWGEHCEHLSMK

MUC4

5351

Q99102
MKCNCKYDGHRIWVH

LOXL3

711

P58215
FEEHIKEEHNMWHYL

ITPR1

2636

Q14643
KEEHNMWHYLCFIVL

ITPR1

2641

Q14643
DEWKHLDHALNCIME

CBFA2T2

346

O43439
HYKDLWDNKHVKMPC

PARG

501

Q86W56
IEAHMEAVHADWKEY

PPL

291

O60437
WCKTMVHTACKDLYH

DGKH

281

Q86XP1
CMQKAQKYQWHVEDL

MACF1

4906

Q9UPN3
MKKEHVLHCQFSAWY

CDC123

1

O75794
SYLHCKWATMEELEK

CHD6

326

Q8TD26
HDHDIIWTEAYMDSK

CACNA2D4

481

Q7Z3S7
DWDDMKGDHVKHYKI

FYN

191

P06241
VFHHWHSYMEDQKEK

FBXL13

56

Q8NEE6
INKYAEHSHDKWSMD

RYR2

2721

Q92736
FTHWKHYMLLCAEEA

SFI1

356

A8K8P3
KAQWEETVTYMTHCH

SYNE3

91

Q6ZMZ3
VSMCLEHLLFDHKYW

SH3TC2

131

Q8TF17
NHVKSMWYPEIKHFC

RHOBTB1

116

O94844
QHYKHEDAKEMPLTW

ZNF572

61

Q7Z3I7
EWCRAMTKKYEHVDI

SMTNL1

386

A8MU46
DMWYHLFKVSHEENI

TAS2R9

151

Q9NYW1
DKKYTYTCLHWHHDM

WDR75

236

Q8IWA0
HVMHAVCWQKYFEAV

UBR1

1161

Q8IWV7
EYNKHAQLWMESTHC

RXFP1

471

Q9HBX9
HEHTYQDKEEVVLWM

TM9SF3

31

Q9HD45
MWRSDLELQFKCYHH

ZMIZ1

601

Q9ULJ6