Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	structural constituent of skin epidermis	KRT5 KRT76 LORICRIN KRT79	5.87e-06	43	55	4	GO:0030280
GeneOntologyMolecularFunction	molybdopterin cofactor binding	AOX1 XDH	1.11e-04	6	55	2	GO:0043546
GeneOntologyMolecularFunction	ubiquitin-like modifier activating enzyme activity	MOCS3 UBA2	3.31e-04	10	55	2	GO:0008641
GeneOntologyMolecularFunction	2 iron, 2 sulfur cluster binding	AOX1 XDH	2.88e-03	29	55	2	GO:0051537
GeneOntologyMolecularFunction	structural molecule activity	COL3A1 KRT5 KRT26 KRT76 LORICRIN EMILIN3 FLG2 KRT79	2.88e-03	891	55	8	GO:0005198
GeneOntologyBiologicalProcess	negative regulation of synapse maturation	NEUROD2 NFATC4	1.87e-05	3	52	2	GO:2000297
GeneOntologyBiologicalProcess	intermediate filament organization	KRT5 KRT26 KRT76 KRT79	3.82e-05	75	52	4	GO:0045109
GeneOntologyBiologicalProcess	keratinization	KRT5 KRT76 LORICRIN KRT79	6.85e-05	87	52	4	GO:0031424
GeneOntologyBiologicalProcess	intermediate filament cytoskeleton organization	KRT5 KRT26 KRT76 KRT79	1.13e-04	99	52	4	GO:0045104
GeneOntologyBiologicalProcess	intermediate filament-based process	KRT5 KRT26 KRT76 KRT79	1.18e-04	100	52	4	GO:0045103
GeneOntologyCellularComponent	keratin filament	KRT5 KRT76 KRTAP1-4 KRTAP1-5 KRT79	7.31e-06	97	58	5	GO:0045095
GeneOntologyCellularComponent	intermediate filament	KRT5 KRT26 KRT76 KRTAP1-4 KRTAP1-5 KRT79	3.88e-05	227	58	6	GO:0005882
GeneOntologyCellularComponent	intermediate filament cytoskeleton	KRT5 KRT26 KRT76 KRTAP1-4 KRTAP1-5 KRT79	8.77e-05	263	58	6	GO:0045111
GeneOntologyCellularComponent	cornified envelope	KRT5 LORICRIN FLG2	9.33e-04	69	58	3	GO:0001533
Domain	2Fe-2S-bd	AOX1 XDH	9.48e-06	2	58	2	IPR002888
Domain	FAD_binding_5	AOX1 XDH	9.48e-06	2	58	2	PF00941
Domain	-	AOX1 XDH	9.48e-06	2	58	2	3.30.365.10
Domain	Ald_Oxase/Xan_DH_a/b	AOX1 XDH	9.48e-06	2	58	2	IPR000674
Domain	AldOxase/xan_DH_Mopterin-bd	AOX1 XDH	9.48e-06	2	58	2	IPR008274
Domain	Ald_Xan_dh_C	AOX1 XDH	9.48e-06	2	58	2	PF01315
Domain	Fer2_2	AOX1 XDH	9.48e-06	2	58	2	PF01799
Domain	-	AOX1 XDH	9.48e-06	2	58	2	3.90.1170.50
Domain	Ald_Xan_dh_C2	AOX1 XDH	9.48e-06	2	58	2	PF02738
Domain	CO_deh_flav_C	AOX1 XDH	9.48e-06	2	58	2	SM01092
Domain	CO_deh_flav_C	AOX1 XDH	9.48e-06	2	58	2	PF03450
Domain	CO_DH_flav_C	AOX1 XDH	9.48e-06	2	58	2	IPR005107
Domain	Ald_Oxase/xanthine_DH	AOX1 XDH	9.48e-06	2	58	2	IPR016208
Domain	-	AOX1 XDH	9.48e-06	2	58	2	1.10.150.120
Domain	Mopterin_DH_FAD-bd	AOX1 XDH	9.48e-06	2	58	2	IPR002346
Domain	Ald_Xan_dh_C	AOX1 XDH	9.48e-06	2	58	2	SM01008
Domain	MOLYBDOPTERIN_EUK	AOX1 XDH	2.84e-05	3	58	2	PS00559
Domain	OxRdtase_Mopterin-bd_dom	AOX1 XDH	2.84e-05	3	58	2	IPR000572
Domain	OxRdtase_Mopterin_BS	AOX1 XDH	2.84e-05	3	58	2	IPR022407
Domain	Keratin_2_head	KRT5 KRT76 KRT79	5.49e-05	24	58	3	IPR032444
Domain	Keratin_2_head	KRT5 KRT76 KRT79	5.49e-05	24	58	3	PF16208
Domain	Filament	KRT5 KRT26 KRT76 KRT79	6.97e-05	71	58	4	SM01391
Domain	Keratin_II	KRT5 KRT76 KRT79	7.02e-05	26	58	3	IPR003054
Domain	IF	KRT5 KRT26 KRT76 KRT79	7.36e-05	72	58	4	PS00226
Domain	Filament	KRT5 KRT26 KRT76 KRT79	7.77e-05	73	58	4	PF00038
Domain	IF	KRT5 KRT26 KRT76 KRT79	9.09e-05	76	58	4	IPR001664
Domain	2Fe2S_fd_BS	AOX1 XDH	9.42e-05	5	58	2	IPR006058
Domain	FAD-bd_2_sub1	AOX1 XDH	9.42e-05	5	58	2	IPR016167
Domain	-	AOX1 XDH	9.42e-05	5	58	2	3.30.43.10
Domain	2FE2S_FER_1	AOX1 XDH	9.42e-05	5	58	2	PS00197
Domain	Fer2	AOX1 XDH	1.41e-04	6	58	2	PF00111
Domain	2FE2S_FER_2	AOX1 XDH	1.41e-04	6	58	2	PS51085
Domain	FAD_PCMH	AOX1 XDH	1.41e-04	6	58	2	PS51387
Domain	CO_DH_flavot_FAD-bd_sub2	AOX1 XDH	1.41e-04	6	58	2	IPR016169
Domain	FAD-bd_2	AOX1 XDH	1.41e-04	6	58	2	IPR016166
Domain	-	AOX1 XDH	1.41e-04	6	58	2	3.30.465.10
Domain	2Fe-2S_ferredoxin-type	AOX1 XDH	1.41e-04	6	58	2	IPR001041
Domain	ThiF_NAD_FAD-bd	MOCS3 UBA2	4.20e-04	10	58	2	IPR000594
Domain	ThiF	MOCS3 UBA2	4.20e-04	10	58	2	PF00899
Domain	EGF_3	SCUBE2 STAB1	6.13e-04	12	58	2	PF12947
Domain	EGF_dom	SCUBE2 STAB1	6.13e-04	12	58	2	IPR024731
Domain	Beta-grasp_dom	AOX1 XDH	8.42e-04	14	58	2	IPR012675
Domain	-	AOX1 XDH	8.42e-04	14	58	2	3.10.20.30
Domain	Intermediate_filament_CS	KRT5 KRT76 KRT79	9.89e-04	63	58	3	IPR018039
Domain	Growth_fac_rcpt_	SCUBE2 DLL3 IGFBPL1 STAB1	1.40e-03	156	58	4	IPR009030
Domain	Aden_trnslctor	SLC25A36 SLC25A29	3.40e-03	28	58	2	IPR002113
Domain	Mit_carrier	SLC25A36 SLC25A29	4.43e-03	32	58	2	IPR002067
Domain	EGF_CA	SCUBE2 DLL3 STAB1	6.46e-03	122	58	3	SM00179
Domain	EGF-like_Ca-bd_dom	SCUBE2 DLL3 STAB1	6.76e-03	124	58	3	IPR001881
Domain	Keratin_B2	KRTAP1-4 KRTAP1-5	6.85e-03	40	58	2	PF01500
Domain	EGF	SCUBE2 DLL3 STAB1	7.06e-03	126	58	3	PF00008
Domain	Keratin_I	KRT26 KRT76	8.25e-03	44	58	2	IPR002957
Pathway	REACTOME_KERATINIZATION	KRT5 KRT26 KRT76 LORICRIN KRTAP1-4 KRTAP1-5 KRT79	5.13e-06	217	45	7	M27640
Pathway	REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE	KRT5 KRT26 KRT76 LORICRIN KRT79	5.41e-05	129	45	5	M27649
Pathway	REACTOME_KERATINIZATION	KRT5 KRT26 KRT76 KRTAP1-5 KRT79	1.21e-04	153	45	5	MM15343
Pathway	REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE	KRT5 KRT26 KRT76 KRT79	1.66e-04	87	45	4	MM15351
Pathway	WP_MOLYBDENUM_COFACTOR_MOCO_BIOSYNTHESIS	AOX1 XDH	2.07e-04	7	45	2	M39799
Pathway	WP_EFFECTS_OF_NITRIC_OXIDE	AOX1 XDH	2.76e-04	8	45	2	M39677
Pubmed	Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia.	COL3A1 KRT5 LORICRIN DLL3	1.47e-06	48	60	4	35247391
Pubmed	Nitrite reductase activity of rat and human xanthine oxidase, xanthine dehydrogenase, and aldehyde oxidase: evaluation of their contribution to NO formation in vivo.	AOX1 XDH	2.93e-06	2	60	2	25537183
Pubmed	New consensus nomenclature for mammalian keratins.	KRT5 KRT26 KRT76 KRT79	4.42e-06	63	60	4	16831889
Pubmed	Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration.	KRT5 LORICRIN KRT79	6.35e-06	21	60	3	24198274
Pubmed	Polymorphism of genes involved in purine metabolism (XDH, AOX1, MOCOS) in kidney transplant recipients receiving azathioprine.	AOX1 XDH	8.77e-06	3	60	2	22495427
Pubmed	Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease.	AOX1 XDH	8.77e-06	3	60	2	19500084
Pubmed	Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate.	EOMES ATOH7 EYA2	1.09e-05	25	60	3	25775587
Pubmed	Polymorphisms in the human high sulfur hair keratin-associated protein 1, KAP1, gene family.	KRTAP1-4 KRTAP1-5	1.75e-05	4	60	2	12228244
Pubmed	AKT1-mediated Lamin A/C degradation is required for nuclear degradation and normal epidermal terminal differentiation.	KRT5 LORICRIN	1.75e-05	4	60	2	26045045
Pubmed	Translational implications of Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensor.	KRT5 LORICRIN FLG2	1.92e-05	30	60	3	34905516
Pubmed	The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level.	KRT5 LORICRIN	2.92e-05	5	60	2	29712925
Pubmed	Transcriptome of Atoh7 retinal progenitor cells identifies new Atoh7-dependent regulatory genes for retinal ganglion cell formation.	ATOH7 EYA2	4.37e-05	6	60	2	24799426
Pubmed	Characterization of G protein-coupled receptor 56 protein expression in the mouse developing neocortex.	EOMES COL3A1	4.37e-05	6	60	2	22351047
Pubmed	Identification of 14-3-3sigma mutation causing cutaneous abnormality in repeated-epilation mutant mouse.	KRT5 LORICRIN	4.37e-05	6	60	2	16239341
Pubmed	GATA-3: an unexpected regulator of cell lineage determination in skin.	KRT5 LORICRIN	4.37e-05	6	60	2	12923059
Pubmed	Programming gene expression in developing epidermis.	KRT5 LORICRIN	4.37e-05	6	60	2	7525178
Pubmed	Loss of proteolytically processed filaggrin caused by epidermal deletion of Matriptase/MT-SP1.	KRT5 LORICRIN	4.37e-05	6	60	2	14638864
Pubmed	The alpha/beta carboxy-terminal domains of p63 are required for skin and limb development. New insights from the Brdm2 mouse which is not a complete p63 knockout but expresses p63 gamma-like proteins.	KRT5 LORICRIN	4.37e-05	6	60	2	19300453
Pubmed	MicroRNA-203 represses selection and expansion of oncogenic Hras transformed tumor initiating cells.	KRT5 LORICRIN	6.11e-05	7	60	2	26203562
Pubmed	Regulation of epidermal differentiation by a Distal-less homeodomain gene.	KRT5 LORICRIN	6.11e-05	7	60	2	8991098
Pubmed	P63 targeted deletion under the FOXN1 promoter disrupts pre-and post-natal thymus development, function and maintenance as well as induces severe hair loss.	KRT5 LORICRIN	6.11e-05	7	60	2	35077450
Pubmed	Dysregulation of Grainyhead-like 3 expression causes widespread developmental defects.	KRT5 LORICRIN	8.14e-05	8	60	2	36606449
Pubmed	BRN2 as a key gene drives the early primate telencephalon development.	EOMES NEUROD2	8.14e-05	8	60	2	35245119
Pubmed	Defining the identity of mouse embryonic dermal fibroblasts.	COL3A1 NFATC4	8.14e-05	8	60	2	27265328
Pubmed	Essential roles of Tbx3 in embryonic skin development during epidermal stratification.	KRT5 LORICRIN	8.14e-05	8	60	2	28205312
Pubmed	Glucocorticoid receptor antagonizes EGFR function to regulate eyelid development.	KRT5 LORICRIN	8.14e-05	8	60	2	21136383
Pubmed	Evaluation of TRAP-sequencing technology with a versatile conditional mouse model.	EOMES NEUROD2 IGFBPL1	8.50e-05	49	60	3	24165879
Pubmed	Aurora kinase-A deficiency during skin development impairs cell division and stratification.	KRT5 LORICRIN	1.05e-04	9	60	2	22832491
Pubmed	Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13.	KRT76 KRT79	1.05e-04	9	60	2	15737194
Pubmed	Projections and interconnections of genetically defined serotonin neurons in mice.	EOMES COL3A1	1.05e-04	9	60	2	22151329
Pubmed	SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair.	KRT5 LORICRIN	1.05e-04	9	60	2	31492871
Pubmed	Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion.	KRT5 LORICRIN	1.05e-04	9	60	2	22505032
Pubmed	The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis.	KRT5 LORICRIN	1.31e-04	10	60	2	26376988
Pubmed	Single-cell transcriptomics reveals the cellular identity of a novel progenitor population crucial for murine neural tube closure.	KRT5 LORICRIN	1.31e-04	10	60	2	39296075
Pubmed	Two Ancient Gene Families Are Critical for Maintenance of the Mammalian Skin Barrier in Postnatal Life.	KRT5 LORICRIN	1.31e-04	10	60	2	26975724
Pubmed	Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2.	KRT5 LORICRIN	1.31e-04	10	60	2	25547114
Pubmed	N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications.	EOMES NEUROD2	1.31e-04	10	60	2	29335608
Pubmed	Spatiotemporal expression pattern of keratins in skin of AP-2alpha-deficient mice.	KRT5 LORICRIN	1.31e-04	10	60	2	10571739
Pubmed	Forward genetics identifies Kdf1/1810019J16Rik as an essential regulator of the proliferation-differentiation decision in epidermal progenitor cells.	KRT5 LORICRIN	1.31e-04	10	60	2	24075906
Pubmed	Tcf3 expression marks both stem and progenitor cells in multiple epithelia.	KRT5 LORICRIN	1.31e-04	10	60	2	25038042
Pubmed	Dynamic interactions between intermediate neurogenic progenitors and radial glia in embryonic mouse neocortex: potential role in Dll1-Notch signaling.	EOMES DLL3	1.59e-04	11	60	2	23699523
Pubmed	FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development.	KRT5 LORICRIN	1.59e-04	11	60	2	11062007
Pubmed	Increased retinoic acid levels through ablation of Cyp26b1 determine the processes of embryonic skin barrier formation and peridermal development.	KRT5 LORICRIN	1.59e-04	11	60	2	22366455
Pubmed	A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.	KRT5 LORICRIN FLG2	1.72e-04	62	60	3	26644517
Pubmed	Replication of top markers of a genome-wide association study in multiple sclerosis in Spain.	SLC25A36 PDZRN4	1.91e-04	12	60	2	20944657
Pubmed	Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus.	EOMES NFATC4	1.91e-04	12	60	2	22586092
Pubmed	Transitional basal cells at the squamous-columnar junction generate Barrett's oesophagus.	KRT5 LORICRIN	1.91e-04	12	60	2	29019984
Pubmed	The carboxy-terminus of p63 links cell cycle control and the proliferative potential of epidermal progenitor cells.	KRT5 LORICRIN	1.91e-04	12	60	2	25503409
Pubmed	ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis.	KRT5 LORICRIN	1.91e-04	12	60	2	21127502
Pubmed	Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin.	KRT5 LORICRIN	1.91e-04	12	60	2	21262812
Pubmed	Residual embryonic cells as precursors of a Barrett's-like metaplasia.	KRT5 LORICRIN	2.26e-04	13	60	2	21703447
Pubmed	A Ctnnb1 enhancer regulates neocortical neurogenesis by controlling the abundance of intermediate progenitors.	EOMES NEUROD2	2.26e-04	13	60	2	35915089
Pubmed	Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia.	KRT5 LORICRIN	2.26e-04	13	60	2	19718027
Pubmed	Fate and plasticity of the epidermis in response to congenital activation of BRAF.	KRT5 LORICRIN	2.26e-04	13	60	2	25202828
Pubmed	Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain.	KRT5 LORICRIN	2.26e-04	13	60	2	9670011
Pubmed	Role of epidermal primary cilia in the homeostasis of skin and hair follicles.	KRT5 LORICRIN	2.26e-04	13	60	2	21429982
Pubmed	NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures.	KRT5 LORICRIN	2.26e-04	13	60	2	26765568
Pubmed	Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope.	KRT5 LORICRIN	2.26e-04	13	60	2	8999895
Pubmed	Wnt7b is an important intrinsic regulator of hair follicle stem cell homeostasis and hair follicle cycling.	KRT5 LORICRIN	2.26e-04	13	60	2	24222445
Pubmed	The mineralocorticoid receptor plays a transient role in mouse skin development.	KRT5 LORICRIN	2.26e-04	13	60	2	26268211
Pubmed	Glucocorticoid receptor is required for skin barrier competence.	KRT5 LORICRIN	2.26e-04	13	60	2	18039792
Pubmed	Pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice.	EOMES NEUROD2	2.63e-04	14	60	2	33203851
Pubmed	The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny.	KRT5 LORICRIN	2.63e-04	14	60	2	17360773
Pubmed	Comparison of the Spatiotemporal Expression Patterns of Three Cre Lines, Emx1IRES-Cre, D6-Cre and hGFAP-Cre, Commonly Used in Neocortical Development Research.	EOMES NEUROD2	2.63e-04	14	60	2	34550336
Pubmed	Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia.	KRT5 LORICRIN	2.63e-04	14	60	2	16914743
Pubmed	EMILIN1-α4/α9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation.	KRT5 LORICRIN	2.63e-04	14	60	2	21949412
Pubmed	COUP-TFI promotes radial migration and proper morphology of callosal projection neurons by repressing Rnd2 expression.	EOMES NEUROD2	2.63e-04	14	60	2	21965613
Pubmed	Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis.	KRT5 LORICRIN	2.63e-04	14	60	2	19786578
Pubmed	The microRNA-200 family coordinately regulates cell adhesion and proliferation in hair morphogenesis.	KRT5 LORICRIN	2.63e-04	14	60	2	29602800
Pubmed	Ras signaling is essential for skin development.	KRT5 LORICRIN	3.03e-04	15	60	2	23831572
Pubmed	Identification of oscillatory genes in somitogenesis from functional genomic analysis of a human mesenchymal stem cell model.	DLL3 GLCCI1	3.03e-04	15	60	2	17362910
Pubmed	Multiple roles of Notch signaling in the regulation of epidermal development.	KRT5 LORICRIN	3.03e-04	15	60	2	18410734
Pubmed	Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice.	KRT5 LORICRIN	3.03e-04	15	60	2	9847250
Pubmed	The histone acetyltransferase inhibitor Nir regulates epidermis development.	KRT5 LORICRIN	3.03e-04	15	60	2	29490983
Pubmed	Synergistic, context-dependent, and hierarchical functions of epithelial components in thymic microenvironments.	KRT5 DLL3	3.46e-04	16	60	2	22464328
Pubmed	Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury.	KRT5 KRT79	3.46e-04	16	60	2	37715952
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	EOMES ZNF787 NEUROD2 NFATC4 ATOH7 SKOR2	3.49e-04	544	60	6	28473536
Pubmed	MicroRNA-205 controls neonatal expansion of skin stem cells by modulating the PI(3)K pathway.	KRT5 LORICRIN	3.91e-04	17	60	2	23974039
Pubmed	Jmjd3 Plays Pivotal Roles in the Proper Development of Early-Born Retinal Lineages: Amacrine, Horizontal, and Retinal Ganglion Cells.	EOMES ATOH7	3.91e-04	17	60	2	32986815
Pubmed	Immunomodulatory role of Keratin 76 in oral and gastric cancer.	KRT76 LORICRIN	3.91e-04	17	60	2	30143634
Pubmed	MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial and ciliary functions by controlling gene promoters.	KRT5 LORICRIN	3.91e-04	17	60	2	37479688
Pubmed	Genetic variants associated with disordered eating.	ATOH7 KLHL8 FLG2	4.07e-04	83	60	3	23568457
Pubmed	Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.	LONRF1 RNF19B FBXO41	4.36e-04	85	60	3	19028597
Pubmed	m6A RNA methylation impacts fate choices during skin morphogenesis.	KRT5 LORICRIN	4.40e-04	18	60	2	32845239
Pubmed	Pygo2 regulates β-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia.	KRT5 LORICRIN	4.40e-04	18	60	2	24982158
Pubmed	USP10 deubiquitinates Tau, mediating its aggregation.	AOX1 TMEM125	4.40e-04	18	60	2	35987808
Pubmed	Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells.	KRT5 LORICRIN	4.40e-04	18	60	2	24735878
Pubmed	Abnormal hair follicle development and altered cell fate of follicular keratinocytes in transgenic mice expressing DeltaNp63alpha.	KRT5 LORICRIN	4.40e-04	18	60	2	20335364
Pubmed	Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells.	KRT5 LORICRIN	4.40e-04	18	60	2	19303854
Pubmed	Onecut1 and Onecut2 transcription factors operate downstream of Pax6 to regulate horizontal cell development.	EOMES ATOH7	4.40e-04	18	60	2	25794677
Pubmed	Adenomatous polyposis coli (APC) is required for normal development of skin and thymus.	KRT5 LORICRIN	4.91e-04	19	60	2	17002498
Pubmed	Patched 1 and patched 2 redundancy has a key role in regulating epidermal differentiation.	KRT5 LORICRIN	4.91e-04	19	60	2	24492243
Pubmed	Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland.	KRT5 LORICRIN	4.91e-04	19	60	2	16901790
Pubmed	Postnatal onset of retinal degeneration by loss of embryonic Ezh2 repression of Six1.	ATOH7 EYA2	4.91e-04	19	60	2	27677711
Pubmed	Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta.	ICAM5 DLL3 IGFBPL1	5.15e-04	90	60	3	15033168
Pubmed	Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function.	KRT5 LORICRIN	5.45e-04	20	60	2	19234195
Pubmed	Epidermal inactivation of the glucocorticoid receptor triggers skin barrier defects and cutaneous inflammation.	KRT5 LORICRIN	5.45e-04	20	60	2	22951731
Pubmed	Decoding spatiotemporal transcriptional dynamics and epithelial fibroblast crosstalk during gastroesophageal junction development through single cell analysis.	KRT5 LORICRIN	5.45e-04	20	60	2	38594232
Pubmed	KCTD1/KCTD15 complexes control ectodermal and neural crest cell functions, and their impairment causes aplasia cutis.	KRT5 LORICRIN	5.45e-04	20	60	2	38113115
Pubmed	Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130.	KRT5 LORICRIN	5.45e-04	20	60	2	12702649
Cytoband	12q13.13	KRT5 KRT76 KRT79	9.58e-05	67	60	3	12q13.13
GeneFamily	Keratins, type II	KRT5 KRT76 KRT79	3.78e-05	27	44	3	609
GeneFamily	Ubiquitin like modifier activating enzymes	MOCS3 UBA2	2.57e-04	10	44	2	100
GeneFamily	Ring finger proteins	LONRF1 RNF112 RNF19B PDZRN4	4.41e-03	275	44	4	58
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Fam159b\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	KRT5 SKOR2 FGD5 IGFBPL1 SORCS1 PDZRN4	5.15e-08	149	60	6	98ae408d2d0347865875ff8bbd89d359decea526
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Neuronal-Neuron\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	EOMES ATOH7 DLL3 EYA2 IGFBPL1	1.43e-07	90	60	5	840f93af13b5c4dd0eb4132c76f017f97a107e28
ToppCell	PCW_07-8.5-Neuronal-Neuronal_postreplicative-neuro_migrating_neuronal_(3)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	MCHR1 DLL3 IGFBPL1 SORCS1 PDZRN4	4.31e-06	179	60	5	df6d2cdc4e204ce1a4628dc71dfbc5e6c6309b2a
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-CR\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	EOMES SKOR2 EYA2 IGFBPL1	4.85e-06	83	60	4	1ab68323518adc7fd0a459b41fad12d60f97eb5c
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-CR-CR_Lhx5\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	EOMES SKOR2 EYA2 IGFBPL1	4.85e-06	83	60	4	75b27d91a4473286f4b40027e96ac5246f5abe5b
ToppCell	PCW_05-06-Neuronal-Neuronal_postreplicative\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	MCHR1 DLL3 IGFBPL1 SORCS1 PDZRN4	5.06e-06	185	60	5	512f489daeb3b72d4578dc6f4d0ebb5f38d5bbab
ToppCell	metastatic_Lymph_Node-Fibroblasts-COL13A1+_matrix_FBs\|metastatic_Lymph_Node / Location, Cell class and cell subclass	COL3A1 MCHR1 RNF112 AOX1 SORCS1	5.33e-06	187	60	5	e04fb35f2f5b120659d06b5ae427ab1ec56d5c36
ToppCell	Biopsy_Control_(H.)-Epithelial-SCGB3A2+\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	CACNA1S XDH TMEM125 GLCCI1 SLC22A17	7.04e-06	198	60	5	1fe51f4beca0eef4ff117e6edaa646e35c0f9629
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GREB1L KRT5 KRT76 TMEM125	6.13e-05	158	60	4	f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GREB1L KRT5 KRT76 TMEM125	6.13e-05	158	60	4	8c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage\|356C / Donor, Lineage, Cell class and subclass (all cells)	MOCS3 FBXO41 SDS STAB1	6.28e-05	159	60	4	24f87c666eff10c1844c900ffd7ad49fa9f80481
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell-DC2_(CD1c+_dendritic_cell)-DC2_L.1.2.1.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LORICRIN RNF19B SLC25A29 STAB1	7.25e-05	165	60	4	76abebe80e5f8bf44825bb619ae86fcb6f66ffeb
ToppCell	wk_08-11-Epithelial-PNS-FGFBP2+_Neural_progenitor\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	MCHR1 DLL3 SORCS1 PDZRN4	9.51e-05	177	60	4	15a5c96ea840376e54933ebe7a8334a11d9ce411
ToppCell	PCW_05-06-Neuronal-Neuronal_postreplicative-neuro_migrating_neuronal_(3)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	DLL3 IGFBPL1 SORCS1 PDZRN4	9.72e-05	178	60	4	38ffbd01230c99f52274424ee6c172381daffc73
ToppCell	NS\|World / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPNS2 DUOX2 XDH SDS	1.01e-04	180	60	4	8472dcce7bc0b7ce428ec17ddf0018f3258f78d2
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-mLTo\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LINC02881 ICAM5 SPNS2 NLGN2	1.01e-04	180	60	4	f103e161e966c257eac97e1b30a461c4ed9cafc2
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KRT5 SCUBE2 DUOX2 EYA2	1.06e-04	182	60	4	678eadd57e7e830fc2bf9fd35616d3badce01705
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell-Papillary_Tip_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KRT5 SCUBE2 DUOX2 EYA2	1.06e-04	182	60	4	8d1229fa5aa6e2e38f2ac6fe4f4dc89752fe9344
ToppCell	wk_15-18-Epithelial-PNS-Early_Schwann\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	DLL3 IGFBPL1 SORCS1 PDZRN4	1.08e-04	183	60	4	7e8366ec8117d36cec67f77dcb0e9a6032d87fcb
ToppCell	PCW_05-06-Neuronal-Neuronal_postreplicative-neuro_immature_neuronal_(2)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	MCHR1 DLL3 IGFBPL1 SORCS1	1.08e-04	183	60	4	9dfb398b9995d562864fe688861a831ada0814cd
ToppCell	droplet-Kidney-nan-21m-Epithelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCUBE2 KCNA6 NFATC4 AOX1	1.08e-04	183	60	4	f55081068213cc1cdb2acad58ff10f6b48b44c72
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	COL3A1 NFATC4 AOX1 EYA2	1.10e-04	184	60	4	235890e8b424f4386b6ea52d173d20a00898df73
ToppCell	facs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SPNS2 DUOX2 FGD5 STAB1	1.13e-04	185	60	4	59acaf025353405948dc34ccccf37ec5c08ea903
ToppCell	wk_15-18-Epithelial-PNS-MFNG+_DBH+_neuron\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	MCHR1 DLL3 IGFBPL1 SORCS1	1.15e-04	186	60	4	72f7427d62d65e37bb0bf99229a1b75df081a128
ToppCell	PCW_07-8.5-Neuronal-Neuronal_postreplicative\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DLL3 IGFBPL1 SORCS1 PDZRN4	1.15e-04	186	60	4	2fdd0a80ad31cf017aafcf5dcf760ebd786b98c1
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF787 SPNS2 GLCCI1 SLC22A17	1.17e-04	187	60	4	3699d5e71d779da922920aa3160895db187bf81b
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF787 SPNS2 GLCCI1 SLC22A17	1.17e-04	187	60	4	033ba52c0c2f9978784947098fa697368ae44834
ToppCell	wk_08-11-Epithelial-PNS-MFNG+_DBH+_neuron\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	MCHR1 DLL3 IGFBPL1 SORCS1	1.20e-04	188	60	4	d3d7d21d4fa39ac4106a164652673de1bef8662d
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL3A1 SCUBE2 AOX1 EYA2	1.22e-04	189	60	4	a153b83314cf52808f685296cff8c95af3f4983d
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL3A1 SCUBE2 AOX1 EYA2	1.22e-04	189	60	4	e9d5e858e320c6e9913c1ea6a54967d21eda605f
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL3A1 NFATC4 AOX1 NLGN2	1.22e-04	189	60	4	d531399749409d614adca13d181830c6e3287508
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Neuron\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	EOMES EYA2 SLC22A17 IGFBPL1	1.22e-04	189	60	4	3717d1148e26ac78a26aea0ca1dbfbb9d3668877
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL3A1 SCUBE2 AOX1 EYA2	1.22e-04	189	60	4	2a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL3A1 SCUBE2 AOX1 EYA2	1.25e-04	190	60	4	d60395739458d7f47a3350ade751fe3819500320
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL3A1 SCUBE2 AOX1 EYA2	1.27e-04	191	60	4	b13229bb7f3713a392271aaf5dbae3edd1b9fe5a
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	KRT5 SPNS2 TMEM125 EYA2	1.30e-04	192	60	4	8899d81306770adda893b5e146df1253971754c5
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	KRT5 SPNS2 TMEM125 EYA2	1.30e-04	192	60	4	5fda9a465c9f77c7fa1a3ea07a2b0374bbc23b2a
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL3A1 SCUBE2 AOX1 EYA2	1.30e-04	192	60	4	dcd924d6eb67d33ee9f5d3e8ab6e1d4283d6b708
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL3A1 SCUBE2 AOX1 EYA2	1.30e-04	192	60	4	ee085e04d5dcfb657522484ed20b8c1ddeccfe0c
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell\|Adult / Lineage, Cell type, age group and donor	COL3A1 NFATC4 AOX1 EYA2	1.30e-04	192	60	4	d21f0f577156f17c899b08871046a26b88aea011
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SCUBE2 ICAM5 TMEM125 GLCCI1	1.35e-04	194	60	4	5b29c843186c2394f5bec3b1d5ae284a0d931d85
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SCUBE2 ICAM5 TMEM125 GLCCI1	1.35e-04	194	60	4	ebcf6c6d0eb20a5d422becf5a730089230c8ba9a
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL3A1 SCUBE2 AOX1 EYA2	1.35e-04	194	60	4	60622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SCUBE2 ICAM5 TMEM125 GLCCI1	1.35e-04	194	60	4	8c6e5ba27a988e0cd6b8c25cb9a30a0da2b1f7f9
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SCUBE2 ICAM5 TMEM125 GLCCI1	1.35e-04	194	60	4	6e78e3046c5b172af92a84e25f982377a0aaac58
ToppCell	367C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	EYA2 SESN1 GLCCI1 STAB1	1.38e-04	195	60	4	4008fa86b5166087a4b20f89ae07e1dfc87c855d
ToppCell	facs-Lung-nan-3m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPNS2 DUOX2 FGD5 STAB1	1.38e-04	195	60	4	7f9b7f15006610ad591063d90e90367bd6083c7f
ToppCell	COPD-Stromal-Fibroblast\|Stromal / Disease state, Lineage and Cell class	AOX1 FGD5 EYA2 PDZRN4	1.41e-04	196	60	4	4930eeb303d174c28fd91021723e26fdf1af9170
ToppCell	distal-3-Epithelial-Proximal_Basal\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KRT5 DUOX2 XDH EYA2	1.41e-04	196	60	4	7e1a565dd2da4f375cbce8842ba4fd6c22ac8375
ToppCell	RA-02._Fibroblast_II\|World / Chamber and Cluster_Paper	AOX1 EYA2 SORCS1 PDZRN4	1.41e-04	196	60	4	e8cbda03837f1f26470a9d93aa7fdaa04e08e38a
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KRT5 NEUROD2 LTB4R EYA2	1.44e-04	197	60	4	1e915957ea6a4550ecb9d6ee4b232aa5800faf20
ToppCell	wk_08-11-Epithelial-PNS\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	MCHR1 DLL3 IGFBPL1 SORCS1	1.44e-04	197	60	4	ce3f9feb6935f0e9daf13673b0a0d6e92817e187
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-IPC_like\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	EOMES NEUROD2 DLL3 IGFBPL1	1.46e-04	198	60	4	6d12ecaa9532c134d9c4562534dcb59a6420b4d3
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-1_mon-IPC_like-IPCs\|1_mon / Sample Type, Dataset, Time_group, and Cell type.	EOMES DLL3 EYA2 IGFBPL1	1.46e-04	198	60	4	b3488e916fff9a4ff62eb897d3783c93296dbd65
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-IPC_like-IPs_and_early_cortical_neurons\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	EOMES NEUROD2 DLL3 IGFBPL1	1.46e-04	198	60	4	7943e4f67c3d6efb5c8b00aa0ff3cfe7be10c48d
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-1_mon-IPC_like\|1_mon / Sample Type, Dataset, Time_group, and Cell type.	EOMES DLL3 EYA2 IGFBPL1	1.46e-04	198	60	4	6d99901d4df24eb3c5cca80afd9a81eb7ee8fcf1
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW10\|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.	EOMES NFATC4 EYA2 IGFBPL1	1.49e-04	199	60	4	8e72efcd421639ac36ed036ee13f13de070d361f
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_adventitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL3A1 AOX1 EYA2 PDZRN4	1.52e-04	200	60	4	ad3fdcef895400f929f2ae12ff9bd85fd46adb3a
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	EOMES NFATC4 EYA2 IGFBPL1	1.52e-04	200	60	4	7c495030e6566b81d97b5516d1972e335ce5ed8c
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Serous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SPNS2 XDH SLC25A29 EYA2	1.52e-04	200	60	4	030efc36bbb848da31b0db3f74d46aac9c79cc9b
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-1m-Neuronal-Neuron\|1m / Sample Type, Dataset, Time_group, and Cell type.	EOMES DLL3 EYA2 IGFBPL1	1.52e-04	200	60	4	be1e153119ca4946b4eaef6037e8465f5c00ca6f
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Neuron\|5w / Sample Type, Dataset, Time_group, and Cell type.	EOMES DLL3 EYA2 IGFBPL1	1.52e-04	200	60	4	6f3fe94107fa2a2ded4888780b36700cce48adb7
ToppCell	LPS_only-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_only / Treatment groups by lineage, cell group, cell type	COL3A1 SCUBE2 AOX1 EYA2	1.52e-04	200	60	4	a7ef7022b8efcaedb7319b0b43d8c4e99d788fe2
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Neuronal-Neuron\|6m / Sample Type, Dataset, Time_group, and Cell type.	EOMES NEUROD2 DLL3 IGFBPL1	1.52e-04	200	60	4	b5019b9d48f32cffd4645a5c0f3e0ac504ea8019
ToppCell	Thalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a7-Tac2-Excitatory_Neuron.Slc17a7.Tac2.Chat_(Habenular_cholinergic_cells)\|Thalamus / BrainAtlas - Mouse McCarroll V32	CCDC142 NEUROD2 IGFBPL1	1.85e-04	82	60	3	51dd9ab3ddb26d3d3395d0c1a156a12a86caf89b
ToppCell	Hippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Lhx1_(Cajal-retzius)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ATOH7 KRT79 SDS	2.06e-04	85	60	3	2c94ff338633c39edb4a3a69a04be33db764c586
ToppCell	Hippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Lhx1_(Cajal-retzius)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ATOH7 KRT79 SDS	2.06e-04	85	60	3	f9e874ae2b3eadf58fbbe7367c5f498a357166ca
Drug	5-hydroxypyrazinoic acid	AOX1 XDH	6.38e-06	2	58	2	CID000161825
Drug	5-hydroxypyrazinamide	AOX1 XDH	6.38e-06	2	58	2	CID000151823
Drug	2-hydroxypurine	AOX1 XDH	1.91e-05	3	58	2	CID000075323
Drug	2-(hydroxymethyl)glutarate	XDH SDS	1.91e-05	3	58	2	CID010261389
Drug	AC1L212F	AOX1 XDH	3.81e-05	4	58	2	CID000013118
Drug	picrolonic acid	AOX1 XDH	3.81e-05	4	58	2	CID000068369
Drug	AC1L3UXH	AOX1 XDH	3.81e-05	4	58	2	CID000065446
Disease	xanthinuria (implicated_via_orthology)	AOX1 XDH	3.80e-06	2	58	2	DOID:0060236 (implicated_via_orthology)
Disease	large artery stroke	MCHR1 FGD5 SLC22A17 IGFBPL1	7.38e-05	113	58	4	EFO_0005524
Disease	Malignant neoplasm of breast	EOMES KRT5 KRT76 ICAM5 XDH FGD5 TMEM125 SORCS1	1.14e-03	1074	58	8	C0006142
Disease	lysophosphatidylcholine 18:2 measurement	COL3A1 EYA2	1.39e-03	28	58	2	EFO_0010361
Disease	hippocampus volume change measurement, age at assessment	LINC02881 MOCS3	1.49e-03	29	58	2	EFO_0008007, EFO_0021492
Disease	neuroblastoma	KRT5 KLHL8 PDZRN4	1.56e-03	116	58	3	EFO_0000621

Protein segments in the cluster

Peptide	Gene	Start	Entry
AAAAGSCGGLGGLGV	EOMES	246	O95936
GGGVGCAPAAGAGRL	GLCCI1	46	Q86VQ1
LVGGVAGSASCGLGL	CCDC142	281	Q17RM4
AGRACANGGTCVEGG	DLL3	396	Q9NYJ7
RLTGTKYGCGGGGCG	AOX1	36	Q06278
GGCASGLGGGEVPAR	PDZRN4	116	Q6ZMN7
GGLGSGACAGFLGNE	KRT26	61	Q7Z3Y9
SCVARSGGAGGGACG	KRT76	31	Q01546
GCQSGIKGGQGHGCV	FLG2	316	Q5D862
AGADGGAGGLLRCLG	LONRF1	111	Q17RB8
GGGGGFGRVSLAGAC	KRT5	41	P13647
VCGGGAASFGGGISL	KRT79	476	Q5XKE5
CVKGGGGGGNGIRDI	DUOX2	941	Q9NRD8
AVCLNGAGGGAGGAA	ICAM5	881	Q9UMF0
TAGVLFCVGGRGGSG	KLHL8	316	Q9P2G9
GALCGQCGSLQGGAA	FGD5	391	Q6ZNL6
GAEGASCGGRAGGRC	IGFBPL1	71	Q8WX77
QTSSCGTGCGIGGGI	KRTAP1-4	31	P0C5Y4
CGTGCGIGGGISYGQ	KRTAP1-5	91	Q9BYS1
GCGGGSSGIGSGCII	LORICRIN	251	P23490
SGCIISGGGSVCGGG	LORICRIN	261	P23490
LCGVGAVLPGTCGGG	TUBGCP6	476	Q96RT7
IGGERGCAFCGGLGH	DDX41	576	Q9UJV9
LLGFSGNCIGCGERG	GREB1L	176	Q9C091
GGGGARGCAQVGVLK	PNPLA7	931	Q6ZV29
ACAGGGLLRSAGVGF	LTB4R	286	Q15722
GAGAGLGTPRGGDVC	MEIS3P2	86	A8K0S8
AGGGGGCCSSERLVI	KCNA6	31	P17658
LASSGGLYCLGGGCG	CACNA1S	1206	Q13698
GGTECAGTCAGAGRL	ATOH7	21	Q8N100
LAGCAGGVAGVLVGH	SLC25A29	6	Q8N8R3
RALGVGGAGCGVQGL	FBXO41	746	Q8TF61
GRAVGLGGGSGCQAT	MCHR1	11	Q99705
CCGGVGAAAIAGIGG	COL3A1	1196	P02461
GCCLRLDMGGWGVGG	EMILIN3	451	Q9NT22
GAIALSVGGGGLLCG	SDS	161	P20132
RVSLHCGKSGGGDGC	SCUBE2	456	Q9NQ36
LCLVGLAGAQRGGGG	NLGN2	6	Q8NFZ4
GTACVLIVGCGGLGC	MOCS3	81	O95396
VGVGGAVGVGGCCSG	OTUD5	131	Q96G74
GANLCLGSGVHGGVD	EYA2	361	O00167
CRGGGCGVSTANGKG	RNF19B	441	Q6ZMZ0
AVSGLLGCKQCGGGR	SESN1	16	Q9Y6P5
GLVGPCGVGGAAAGS	SLC22A17	136	Q8WUG5
GAGGAGGGRVLECPS	NFATC4	101	Q14934
FAGGCGGTVGAILTC	SLC25A36	11	Q96CQ1
AGGRVLVVGAGGIGC	UBA2	16	Q9UBT2
QRGAGGSGCCGARGA	SPNS2	31	Q8IVW8
GSGCCGARGAGGAGV	SPNS2	36	Q8IVW8
GLKDFCVHGGAGGGA	INTS5	246	Q6P9B9
GRCAVGKVRVAGGGG	LINC02881	91	B7Z368
GLGIGGKCGGASLTN	TSPAN16	31	Q9UKR8
VGGGVGAGLAATVGC	RNF112	596	Q9ULX5
LGCCGGQPAGSRGVG	TMEM94	81	Q12767
RGGCGVVGGGGSCSS	ZNF609	1326	O15014
GGCHGLATCRAVGGG	STAB1	956	Q9NY15
LSGTKLGCGEGGCGA	XDH	36	P47989
CVAGVGVGAGAGAGA	SKOR2	356	Q2VWA4
AGLLILCAPGVCGGG	SORCS1	21	Q8WY21
AVGLVAGCGAGGVAL	TMEM125	41	Q96AQ2
VCLECGKGFGHGAGL	ZNF787	281	Q6DD87
LAGAQCQAAGGLGGG	NEUROD2	246	Q15784
CQAAGGLGGGAAHAL	NEUROD2	251	Q15784