Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA helicase activity	DHX57 YTHDC2 DHX33 DHX30 DHX9	4.70e-06	78	63	5	GO:0003724
GeneOntologyMolecularFunction	ATP-dependent activity, acting on RNA	DHX57 YTHDC2 DHX33 DHX30 DHX9	5.33e-06	80	63	5	GO:0008186
GeneOntologyMolecularFunction	helicase activity	DHX57 YTHDC2 DHX33 DHX30 DHX9	1.41e-04	158	63	5	GO:0004386
GeneOntologyMolecularFunction	3'-5' RNA helicase activity	YTHDC2 DHX9	1.46e-04	6	63	2	GO:0034458
GeneOntologyMolecularFunction	ATP hydrolysis activity	GPN1 KIF14 DHX57 YTHDC2 DHX33 DHX30 DHX9	4.65e-04	441	63	7	GO:0016887
GeneOntologyMolecularFunction	small GTPase binding	FMNL3 DOCK10 ODF2 ARHGEF16 PKN3 XPOT	5.18e-04	321	63	6	GO:0031267
GeneOntologyMolecularFunction	calcium ion binding	FAM20C PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1 ASPH CLSTN2 CDH19	5.40e-04	749	63	9	GO:0005509
GeneOntologyMolecularFunction	GTPase binding	FMNL3 DOCK10 ODF2 ARHGEF16 PKN3 XPOT	9.42e-04	360	63	6	GO:0051020
GeneOntologyMolecularFunction	GTPase activating protein binding	FMNL3 GNB5	1.62e-03	19	63	2	GO:0032794
GeneOntologyMolecularFunction	double-stranded RNA binding	DHX33 DHX30 DHX9	1.92e-03	78	63	3	GO:0003725
GeneOntologyMolecularFunction	catalytic activity, acting on RNA	DHX57 YTHDC2 DHX33 ERN2 DHX30 DHX9	1.99e-03	417	63	6	GO:0140098
GeneOntologyBiologicalProcess	homophilic cell adhesion via plasma membrane adhesion molecules	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1 CLSTN2 CDH19 PLXNB2	8.74e-08	187	62	8	GO:0007156
GeneOntologyBiologicalProcess	cell-cell adhesion via plasma-membrane adhesion molecules	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1 CLSTN2 CDH19 PLXNB2	4.27e-06	313	62	8	GO:0098742
GeneOntologyBiologicalProcess	positive regulation of molecular function	CASS4 JAK2 SEMG2 ARHGAP6 EDF1 GNB5 RALGAPB ASPH DOCK10 KIF14 DHX33 ERN2 ARHGEF16 RNF207 DHX9	1.60e-05	1430	62	15	GO:0044093
GeneOntologyBiologicalProcess	positive regulation of catalytic activity	CASS4 JAK2 SEMG2 ARHGAP6 GNB5 RALGAPB ASPH DOCK10 KIF14 ERN2 ARHGEF16 DHX9	4.73e-05	1028	62	12	GO:0043085
GeneOntologyBiologicalProcess	positive regulation of hydrolase activity	JAK2 SEMG2 ARHGAP6 GNB5 RALGAPB ASPH DOCK10 ARHGEF16	1.19e-04	499	62	8	GO:0051345
GeneOntologyCellularComponent	piccolo histone acetyltransferase complex	EPC2 EPC1	6.05e-05	4	67	2	GO:0032777
MousePheno	duplex kidney	CC2D2A PLXNB2 PCNT	2.72e-05	19	44	3	MP:0004017
MousePheno	ectopic Purkinje cell	UNC5C KIF14 PLXNB2	7.19e-05	26	44	3	MP:0000885
Domain	DUF1605	DHX57 YTHDC2 DHX33 DHX30 DHX9	2.41e-09	17	64	5	IPR011709
Domain	OB_NTP_bind	DHX57 YTHDC2 DHX33 DHX30 DHX9	2.41e-09	17	64	5	PF07717
Domain	HA2	DHX57 YTHDC2 DHX33 DHX30 DHX9	3.33e-09	18	64	5	SM00847
Domain	HA2	DHX57 YTHDC2 DHX33 DHX30 DHX9	3.33e-09	18	64	5	PF04408
Domain	Helicase-assoc_dom	DHX57 YTHDC2 DHX33 DHX30 DHX9	3.33e-09	18	64	5	IPR007502
Domain	CADHERIN_1	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1 CLSTN2 CDH19	1.15e-07	113	64	7	PS00232
Domain	Cadherin	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1 CLSTN2 CDH19	1.15e-07	113	64	7	PF00028
Domain	CADHERIN_2	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1 CLSTN2 CDH19	1.22e-07	114	64	7	PS50268
Domain	-	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1 CLSTN2 CDH19	1.22e-07	114	64	7	2.60.40.60
Domain	CA	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1 CLSTN2 CDH19	1.30e-07	115	64	7	SM00112
Domain	Cadherin-like	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1 CLSTN2 CDH19	1.38e-07	116	64	7	IPR015919
Domain	Cadherin	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1 CLSTN2 CDH19	1.55e-07	118	64	7	IPR002126
Domain	Cadherin_tail	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1	1.61e-07	37	64	5	PF15974
Domain	Cadherin_CBD	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1	1.61e-07	37	64	5	IPR031904
Domain	DEAH_ATP_HELICASE	DHX57 YTHDC2 DHX33 DHX30 DHX9	1.85e-07	38	64	5	PS00690
Domain	Cadherin_C	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1	3.11e-07	42	64	5	IPR032455
Domain	Cadherin_C_2	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1	3.11e-07	42	64	5	PF16492
Domain	Cadherin_CS	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1 CDH19	1.96e-06	109	64	6	IPR020894
Domain	Cadherin_2	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1	2.84e-06	65	64	5	PF08266
Domain	Cadherin_N	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1	2.84e-06	65	64	5	IPR013164
Domain	DEAD/DEAH_box_helicase_dom	DHX57 YTHDC2 DHX33 DHX30 DHX9	5.06e-06	73	64	5	IPR011545
Domain	DEAD	DHX57 YTHDC2 DHX33 DHX30 DHX9	5.06e-06	73	64	5	PF00270
Domain	DNA/RNA_helicase_DEAH_CS	DHX57 DHX33 DHX30 DHX9	6.06e-06	35	64	4	IPR002464
Domain	Enhancer_polycomb	EPC2 EPC1	1.16e-05	2	64	2	IPR024943
Domain	Enhancer_polycomb_C	EPC2 EPC1	1.16e-05	2	64	2	IPR009607
Domain	E_Pc_C	EPC2 EPC1	1.16e-05	2	64	2	PF06752
Domain	Helicase_C	DHX57 YTHDC2 DHX33 DHX30 DHX9	3.27e-05	107	64	5	PF00271
Domain	HELICc	DHX57 YTHDC2 DHX33 DHX30 DHX9	3.27e-05	107	64	5	SM00490
Domain	Helicase_C	DHX57 YTHDC2 DHX33 DHX30 DHX9	3.42e-05	108	64	5	IPR001650
Domain	HELICASE_CTER	DHX57 YTHDC2 DHX33 DHX30 DHX9	3.58e-05	109	64	5	PS51194
Domain	HELICASE_ATP_BIND_1	DHX57 YTHDC2 DHX33 DHX30 DHX9	3.58e-05	109	64	5	PS51192
Domain	DEXDc	DHX57 YTHDC2 DHX33 DHX30 DHX9	3.58e-05	109	64	5	SM00487
Domain	Helicase_ATP-bd	DHX57 YTHDC2 DHX33 DHX30 DHX9	3.74e-05	110	64	5	IPR014001
Domain	EPL1	EPC2 EPC1	3.19e-04	8	64	2	PF10513
Domain	Enhancer_polycomb-like_N	EPC2 EPC1	3.19e-04	8	64	2	IPR019542
Domain	DUF1220	NBPF4 NBPF6	4.10e-04	9	64	2	SM01148
Domain	NBPF_dom	NBPF4 NBPF6	6.23e-04	11	64	2	IPR010630
Domain	NBPF	NBPF4 NBPF6	6.23e-04	11	64	2	PS51316
Domain	DUF1220	NBPF4 NBPF6	6.23e-04	11	64	2	PF06758
Domain	dsrm	DHX30 DHX9	2.11e-03	20	64	2	PF00035
Domain	DS_RBD	DHX30 DHX9	2.33e-03	21	64	2	PS50137
Domain	Rho_GTPase_activation_prot	ARHGAP6 ARHGAP31 PLXNB2	3.42e-03	88	64	3	IPR008936
Domain	P-loop_NTPase	GPN1 KIF14 DHX57 YTHDC2 DHX33 MYO18B DHX30 DHX9	8.16e-03	848	64	8	IPR027417
Pathway	REACTOME_RHO_GTPASE_CYCLE	FMNL3 ARHGAP6 ARHGAP31 DOCK10 KIF14 ARHGEF16 PKN3 AKAP12	1.17e-05	439	36	8	MM15595
Pathway	REACTOME_RHO_GTPASE_CYCLE	FMNL3 ARHGAP6 ARHGAP31 DOCK10 KIF14 ARHGEF16 PKN3 AKAP12	1.40e-05	450	36	8	M27078
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	FMNL3 ARHGAP6 ARHGAP31 DOCK10 KIF14 ARHGEF16 PKN3 AKAP12	1.86e-04	649	36	8	MM15690
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1	2.16e-07	68	67	5	11230163
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1	2.89e-07	72	67	5	10380929
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1	3.31e-07	74	67	5	10817752
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	ASPH DHX57 YTHDC2 DHX33 PC PKN3 DHX30 DHX9 PCNT	3.94e-07	486	67	9	30940648
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1	4.04e-07	77	67	5	10835267
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1	4.90e-07	80	67	5	10716726
Pubmed	Maturation of postnatally generated olfactory bulb granule cells depends on functional γ-protocadherin expression.	PCDHGA10 PCDHGA7 PCDHGA4	3.06e-06	15	67	3	23515096
Pubmed	The enhancer of polycomb gene of Drosophila encodes a chromatin protein conserved in yeast and mammals.	EPC2 EPC1	3.66e-06	2	67	2	9735366
Pubmed	A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.	NBPF4 NBPF6 NBPF5P	8.87e-06	21	67	3	16079250
Pubmed	Leat-associated seizures the possible role of EAAT2, pyruvate carboxylase and glutamine synthetase.	PC SLC1A2	1.10e-05	3	67	2	38086219
Pubmed	Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells.	EPC2 EPC1	1.10e-05	3	67	2	24166297
Pubmed	CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism.	EPC2 EPC1 JAZF1	1.18e-05	23	67	3	31281901
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHGA10 PCDHGA7 PCDHGA4	2.16e-05	28	67	3	15347688
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	EDF1 GOSR1 RALGAPB ASPH BRD9 KIF14 DHX57 YTHDC2 RBM8A DHX33 ODF2 DHX30	2.58e-05	1497	67	12	31527615
Pubmed	Functional significance of isoform diversification in the protocadherin gamma gene cluster.	PCDHGA10 PCDHGA7 PCDHGA4	3.92e-05	34	67	3	22884324
Pubmed	RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation.	ZNF131 EPC2 EPC1	4.66e-05	36	67	3	17573780
Pubmed	The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity.	ODF2 PCNT	5.46e-05	6	67	2	16980960
Pubmed	The transition from meiotic to mitotic spindle assembly is gradual during early mammalian development.	ODF2 PCNT	5.46e-05	6	67	2	22851319
Pubmed	Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.	ASPH DHX57 YTHDC2 DHX30 DHX9	7.24e-05	223	67	5	20020773
Pubmed	Synaptic, transcriptional and chromatin genes disrupted in autism.	RALGAPB DHX57	7.63e-05	7	67	2	25363760
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	SEMG2 ASPH KIF14 TEKT1 DHX57 YTHDC2 RBM8A PCNT	8.09e-05	732	67	8	34732716
Pubmed	A differential developmental pattern of spinal interneuron apoptosis during synaptogenesis: insights from genetic analyses of the protocadherin-gamma gene cluster.	PCDHGA10 PCDHGA7 PCDHGA4	8.55e-05	44	67	3	19029045
Pubmed	TRAP150 activates pre-mRNA splicing and promotes nuclear mRNA degradation.	RBM8A DHX9	1.02e-04	8	67	2	20123736
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	RALGAPB ASPH DHX57 PC DHX30 XPOT DHX9	1.58e-04	601	67	7	33658012
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	EDF1 GPN1 ASPH DHX57 YTHDC2 DHX30 DHX9	1.81e-04	615	67	7	31048545
Pubmed	Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.	PCDHGA10 PCDHGA7 PCDHGA4	1.86e-04	57	67	3	32633719
Pubmed	CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.	PCDHGA10 PCDHGA7 PCDHGA4	1.95e-04	58	67	3	30377227
Pubmed	Gradual centriole maturation associates with the mitotic surveillance pathway in mouse development.	ODF2 PCNT	1.99e-04	11	67	2	33410253
Pubmed	The centrosome protein AKNA regulates neurogenesis via microtubule organization.	ODF2 PCNT	1.99e-04	11	67	2	30787442
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	EDF1 GOSR1 GPN1 CCDC138 KIF14 ODF2 PC PCNT	2.30e-04	853	67	8	28718761
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	EPC2 EDF1 EPC1 CCDC138 KIF14 ODF2 PCNT	2.42e-04	645	67	7	25281560
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	FMNL3 PLXNB2 PKN3 DHX30 XPOT	3.50e-04	313	67	5	38270169
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1 UNC5C CC2D2A DHX57 ODF2 PCNT	4.19e-04	1442	67	10	35575683
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	ZNF131 EDF1 YTHDC2 PC PKN3 AKAP12 DHX30 PCNT	4.22e-04	934	67	8	33916271
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	YTHDC2 PC DHX30 DHX9	4.30e-04	182	67	4	32239614
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	JAK2 GCFC2 RALGAPB KCNN1 MYO18B	4.39e-04	329	67	5	17474147
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	DHX57 YTHDC2 RBM8A DHX33 DHX30	4.58e-04	332	67	5	25693804
Pubmed	Combinatorial CRISPR screen identifies fitness effects of gene paralogues.	EPC2 GCFC2 GNB5 EPC1	4.67e-04	186	67	4	33637726
Pubmed	Ciliopathy-associated gene Cc2d2a promotes assembly of subdistal appendages on the mother centriole during cilia biogenesis.	CC2D2A ODF2	4.88e-04	17	67	2	24947469
Pubmed	TRIM24 is an insulin-responsive regulator of P-bodies.	YTHDC2 DHX30 DHX9	5.05e-04	80	67	3	35803934
Pubmed	The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes.	EPC2 EPC1	6.12e-04	19	67	2	15647280
Pubmed	Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium.	CASS4 CLSTN2	6.12e-04	19	67	2	25367360
Pubmed	The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly.	ODF2 PCNT	6.12e-04	19	67	2	24421332
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	GCFC2 RALGAPB ASPH YTHDC2 RBM8A ODF2 DHX9	7.19e-04	774	67	7	15302935
Pubmed	KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation.	EPC2 EPC1	7.50e-04	21	67	2	27270040
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	FMNL3 ARHGAP31 DOCK10 PLXNB2 AKAP12	8.11e-04	377	67	5	38117590
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	EPC2 GOSR1 EPC1 ASPH JAZF1 RBM8A DHX33 PC DHX9	8.16e-04	1294	67	9	30804502
Pubmed	The deubiquitinase USP7 stabilizes Maf proteins to promote myeloma cell survival.	DHX57 YTHDC2 DHX30 DHX9	8.74e-04	220	67	4	31822558
Pubmed	Identification of a USP9X Substrate NFX1-123 by SILAC-Based Quantitative Proteomics.	DHX57 YTHDC2 RBM8A DHX30 DHX9	8.81e-04	384	67	5	31059266
Pubmed	WWP2-WWP1 ubiquitin ligase complex coordinated by PPM1G maintains the balance between cellular p73 and ΔNp73 levels.	GPN1 PC DHX9	8.85e-04	97	67	3	25071155
Pubmed	MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks.	EPC2 EPC1	9.01e-04	23	67	2	20332121
Pubmed	Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans.	EPC2 EPC1	9.01e-04	23	67	2	14966270
Pubmed	GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer.	ASPH DHX57 DHX30 DHX9	9.19e-04	223	67	4	33731348
Pubmed	Molecular genetics of successful smoking cessation: convergent genome-wide association study results.	CLSTN2 MYO18B SLC1A2	9.95e-04	101	67	3	18519826
Pubmed	Proximity interactions among centrosome components identify regulators of centriole duplication.	CCDC138 KIF14 PCNT	9.95e-04	101	67	3	24613305
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	EPC2 EPC1 BRD9 JAZF1 DHX9	1.03e-03	398	67	5	35016035
Pubmed	Centrosome anchoring regulates progenitor properties and cortical formation.	ODF2 PCNT	1.07e-03	25	67	2	32238932
Pubmed	Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.	PCDHGA4 UNC5C GNB5 RALGAPB SLC1A2	1.12e-03	405	67	5	38187761
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RALGAPB DOCK10 HEATR5A DHX30 PCNT	1.14e-03	407	67	5	12693553
Pubmed	Epidermal development requires ninein for spindle orientation and cortical microtubule organization.	ODF2 PCNT	1.15e-03	26	67	2	30923192
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	JAK2 FAM20C TXNRD2 PC PLXNB2 PKN3 DHX30 PCNT	1.26e-03	1105	67	8	35748872
Pubmed	A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.	TXNRD2 TUFT1 XPOT DHX9 PCNT	1.30e-03	419	67	5	28700943
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	GOSR1 UNC5C RALGAPB PLXNB2 AKAP12	1.32e-03	421	67	5	36976175
Pubmed	Full function of exon junction complex factor, Rbm8a, is critical for interneuron development.	RBM8A SLC1A2	1.34e-03	28	67	2	33154347
Pubmed	Novel interactors and a role for supervillin in early cytokinesis.	KIF14 ODF2	1.34e-03	28	67	2	20309963
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	EPC2 DCDC1 EPC1 BRD9 JAZF1 TEKT1 YTHDC2 CLSTN2	1.34e-03	1116	67	8	31753913
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	KIF14 DHX57 YTHDC2 DHX9	1.40e-03	250	67	4	33536335
Pubmed	Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development.	UNC5C PLXNB2	1.54e-03	30	67	2	32562661
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	KIF14 DHX57 YTHDC2 DHX30 XPOT PCNT	1.62e-03	653	67	6	22586326
Pubmed	Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication.	DHX57 DHX30 DHX9	1.67e-03	121	67	3	34029587
Pubmed	Cenpj Regulates Cilia Disassembly and Neurogenesis in the Developing Mouse Cortex.	ODF2 PCNT	1.86e-03	33	67	2	30626697
Pubmed	Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.	JAK2 GOSR1 DHX33 TXNRD2 PCNT	1.90e-03	457	67	5	32968282
Interaction	ING5 interactions	EPC2 EPC1 JAZF1 ODF2 TUFT1 PCNT	1.98e-06	114	66	6	int:ING5
Interaction	YEATS4 interactions	EPC2 EPC1 JAZF1 KIF14 PKN3 TUFT1	2.90e-05	182	66	6	int:YEATS4
Interaction	PCDHGA10 interactions	PCDHGA10 PCDHGA7 PCDHGA4	3.13e-05	19	66	3	int:PCDHGA10
Interaction	BRD7 interactions	ASPH BRD9 DHX57 YTHDC2 DHX33 PC PKN3 DHX30 DHX9 PCNT	3.97e-05	637	66	10	int:BRD7
Interaction	PCDHGA6 interactions	PCDHGA7 PCDHGA4 GOSR1	6.46e-05	24	66	3	int:PCDHGA6
Interaction	TDRD3 interactions	CCDC138 CC2D2A DHX57 RBM8A DHX30 DHX9	6.78e-05	212	66	6	int:TDRD3
Interaction	PCDHGA7 interactions	PCDHGA10 PCDHGA7 PCDHGA4	7.33e-05	25	66	3	int:PCDHGA7
Cytoband	5q31	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1	7.71e-07	115	67	5	5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr5q31	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1	7.74e-05	298	67	5	chr5q31
Cytoband	1p13.3	NBPF4 NBPF6 NBPF5P	1.45e-04	69	67	3	1p13.3
Cytoband	9q34.11	ODF2 PKN3	2.76e-03	53	67	2	9q34.11
Cytoband	Ensembl 112 genes in cytogenetic band chr1p13	NBPF4 NBPF6 NBPF5P	3.69e-03	211	67	3	chr1p13
Cytoband	Ensembl 112 genes in cytogenetic band chr11p13	DCDC1 SLC1A2	4.11e-03	65	67	2	chr11p13
GeneFamily	DEAH-box helicases	DHX57 DHX33 DHX30 DHX9	5.96e-08	16	45	4	500
GeneFamily	Clustered protocadherins	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1	5.19e-07	64	45	5	20
GeneFamily	Neuroblastoma breakpoint family	NBPF4 NBPF6 NBPF5P	2.46e-05	23	45	3	662
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP6 ARHGAP31	6.88e-03	50	45	2	721
ToppCell	droplet-Heart-nan-24m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM20C DOCK10 KCNN1 DHX33 PC	4.19e-06	159	67	5	7ad3a91d29639b32f6264c91f401c14a35469ac0
ToppCell	RA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	UNC5C CCDC138 CLSTN2 CDH19 AKAP12	7.87e-06	181	67	5	2b6ddeb53a79a658e2ba78527ff48c155b20daa6
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like-C\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1	8.52e-06	184	67	5	629cfed10e1112cf30f6a828ce9efbbc6b207789
ToppCell	RA-02._Fibroblast_II\|World / Chamber and Cluster_Paper	UNC5C CCDC138 CLSTN2 CDH19 AKAP12	1.16e-05	196	67	5	e8cbda03837f1f26470a9d93aa7fdaa04e08e38a
Disease	mental development measurement	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1	2.28e-09	25	65	5	EFO_0008230
Disease	Sarcosine measurement	PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1	1.84e-07	23	65	4	EFO_0021668
Disease	childhood trauma measurement, alcohol consumption measurement	PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1	5.16e-07	71	65	5	EFO_0007878, EFO_0007979
Disease	mean platelet volume	JAK2 PCDHGA10 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1 EPC1 DOCK10 NBPF6	3.83e-04	1020	65	9	EFO_0004584
Disease	cardiac troponin I measurement	FMNL3 JAZF1 TEKT1 PLXNB2	6.24e-04	176	65	4	EFO_0010071
Disease	Meckel syndrome type 1	KIF14 CC2D2A	7.15e-04	18	65	2	C3714506
Disease	susceptibility to pneumonia measurement	ARHGAP6 UNC5C PLXNB2	1.30e-03	97	65	3	EFO_0008410
Disease	lymphocyte count	ZNF131 PCDHGA10 ARHGAP31 PCDHGA7 PCDHGA4 PCDHGA2 PCDHGA1 DOCK10 JAZF1 PLXNB2	1.30e-03	1464	65	10	EFO_0004587
Disease	hair colour measurement	DOCK10 JAZF1 SHC4 PC PLXNB2 AKAP12	2.33e-03	615	65	6	EFO_0007822
Disease	liver cirrhosis (biomarker_via_orthology)	JAK2 AKAP12	2.56e-03	34	65	2	DOID:5082 (biomarker_via_orthology)
Disease	ciliopathy (implicated_via_orthology)	CC2D2A TEKT1	3.53e-03	40	65	2	DOID:0060340 (implicated_via_orthology)
Disease	progression free survival, response to carboplatin, methylcobalamin deficiency type cblE, ovarian serous carcinoma	MYO18B CDH19	3.89e-03	42	65	2	EFO_0004920, EFO_1001516, GO_0097328, MONDO_0009354
Disease	APOE carrier status, cerebral amyloid angiopathy	DOCK10 YTHDC2	3.89e-03	42	65	2	EFO_0006790, EFO_0007659
Disease	resting heart rate	FMNL3 ASPH RNF207	4.38e-03	149	65	3	EFO_0004351

Protein segments in the cluster

Peptide	Gene	Start	Entry
EKEEESEHHLQRAIS	EPC1	46	Q9H2F5
EKEEESEHHLQRAIS	EPC2	46	Q52LR7
RTTAVEEHEVEAEIL	CFAP54	2596	Q96N23
IDAIHRSTDHIEESV	CASS4	476	Q9NQ75
EEHVLALVEHAADEA	BRD9	296	Q9H8M2
HQEEVVAEVHVSTVE	AKAP12	411	Q02952
VEDISDILEEHAEKH	ARHGEF16	356	Q5VV41
FETLEPEVSHEETEH	ASPH	196	Q12797
PVVEDERLHHDTDDV	ASPH	241	Q12797
EGVSHVIVDEVHERD	DHX30	551	Q7L2E3
EVSILHEDQVSDKEH	CLSTN2	786	Q9H4D0
ALVVESEHPHDEEEE	NBPF4	241	Q96M43
DREEERVHHLVLTAS	PCDHGA7	201	Q9Y5G6
DREEEAVHHLVLVAS	PCDHGA2	201	Q9Y5H1
FVTGVHEEATEEDIH	RBM8A	76	Q9Y5S9
HDVELHQVAERVEAL	GNB5	76	O14775
HSTEEHLRDFEREIE	JAK2	886	O60674
VLERALDREEEAVHH	PCDHGA4	226	Q9Y5G9
LDREEEAVHHLVLTA	PCDHGA4	231	Q9Y5G9
EHHKEQEEVSRLIDE	DCDC1	431	M0R2J8
TKTEFVEGEEHDHRI	KIF14	581	Q15058
EHDHLRNSDRLIEET	GOSR1	166	O95249
TEEIDALVHREIISH	METAP1D	121	Q6UB28
LAHLEEEVHDKVVAR	ERN2	741	Q76MJ5
DLVSELHAQHEELEA	KCNN1	466	Q92952
LADLIEHIEDNHIDT	JAZF1	26	Q86VZ6
LDRETEELHHDRVTL	EDF1	61	O60869
ERHEALHEDVTGQER	GPATCH3	301	Q96I76
DVHVHEVVDASLSVI	PLXNB2	1701	O15031
EVHVLEHTKIEEEDV	PDC	231	P20941
VASVEDVEDHRIKIH	L3MBTL1	536	Q9Y468
REEEAIHHLVLTASD	PCDHGA10	206	Q9Y5H3
ELEESHRHQLEALES	PCNT	596	O95613
DDIDHRVTEESHEEP	GPN1	341	Q9HCN4
GIDVSLEEEHSVHDV	ARHGAP6	451	O43182
VLETLVTVAEEHHRA	HEATR5A	1926	Q86XA9
DRNVIETKEHIDTHR	CC2D2A	951	Q9P2K1
QHDAEVEHLTEVLKE	CCDC138	246	Q96M89
DIVHHVDTEANIATE	DOCK10	1471	Q96BY6
RTLDVSTDEEDKIHH	GCFC2	91	P16383
LHSVVDDDLDTEHRA	FAM20C	566	Q8IXL6
GVSHIIVDEVHERTE	DHX57	661	Q6P158
LDTIDSQHRVHEDIE	SLC1A2	501	P43004
EKVEELEEHVSHLTE	FMNL3	396	Q8IVF7
VILDEAHERTIHTDV	DHX33	191	Q9H6R0
ISAVDRDESIEEHHF	CDH19	491	Q9H159
SHVIVDEIHERDINT	DHX9	506	Q08211
EELQHRLHVEAAVAE	PKN3	181	Q6P5Z2
AEVSLHEEILEIEVH	KBTBD12	161	Q3ZCT8
ELEEVAHELAETEHE	ODF2	161	Q5BJF6
AHELAETEHENTVLR	ODF2	166	Q5BJF6
DREEEAVHHLILTAS	PCDHGA1	201	Q9Y5H4
EVRHSAAEEEDAIHA	RNF207	231	Q6ZRF8
ALVVESEHPHDEEEE	NBPF5P	241	Q86XG9
ALVVESEHPHDEEEE	NBPF6	241	Q5VWK0
DLVHDTVEHELIKEA	TEKT1	126	Q969V4
IVITEHEVAQDDHLT	SEMG2	556	Q02383
ESEEVHIDSHAEERE	SHC4	356	Q6S5L8
ELVESHDGHEEIIKV	TUFT1	66	Q9NNX1
DVSVRLHHELENVEE	SOGA3	446	Q5TF21
REVEIVSQEEEDVTH	ARHGAP31	866	Q2M1Z3
DLHEIVTEELEERHE	RALGAPB	1046	Q86X10
DKTITEVDEEHVHRA	MYO18B	551	Q8IUG5
IIDDLIERSHESHDR	ZNF717	96	Q9BY31
THVIVDEVHERDRFS	YTHDC2	311	Q9H6S0
SEEEAVARHGQEHVE	TXNRD2	411	Q9NNW7
SELVDRDVVHTSEEA	XPOT	151	O43592
QTEEGTEVHVEELHV	ZNF131	531	P52739
VEDSTDVHVLIEDHR	PTGES3L	66	E9PB15
HQKDHIVDERVDETS	UNC5C	101	O95185
TEEITDVDLVHAQIH	PC	336	P11498