Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	IQ	CEP131 MYO1E	6.57e-03	71	32	2	PF00612
Domain	IQ_motif_EF-hand-BS	CEP131 MYO1E	1.04e-02	90	32	2	IPR000048
Domain	IQ	CEP131 MYO1E	1.10e-02	93	32	2	PS50096
Pubmed	A phase II trial of erlotinib in combination with gemcitabine and capecitabine in previously untreated metastatic/recurrent pancreatic cancer: combined analysis with translational research.	ERCC2 EGFR	9.28e-07	2	34	2	21404106
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	GREB1L CKAP5 SIN3B CEP131 ERCC2 TMED10 CWC27 SPTY2D1 CORO1C STOM	1.08e-06	1497	34	10	31527615
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	CKAP5 SIN3B EGFR CORO1C SPDL1	4.86e-06	256	34	5	33397691
Pubmed	Pharmacogenetic analysis in neoadjuvant chemoradiation for rectal cancer: high incidence of somatic mutations and their relation with response.	ERCC2 EGFR	1.39e-05	6	34	2	20504250
Pubmed	Epidermal growth factor receptor intron 1 CA dinucleotide repeat polymorphism and survival of advanced gastric cancer patients treated with cetuximab plus modified FOLFOX6.	ERCC2 EGFR	1.94e-05	7	34	2	20047592
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	CKAP5 DDX47 EVPL PPP1R9B PTPN14 MYO1E EGFR CORO1C	2.24e-05	1257	34	8	36526897
Pubmed	Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.	SECISBP2L SIN3B PPP1R9B MYO1E CORO1C	2.55e-05	361	34	5	30344098
Pubmed	A genome-wide association study on thyroid function and anti-thyroid peroxidase antibodies in Koreans.	ANO5 PTPN14	2.59e-05	8	34	2	24722205
Pubmed	A protein interaction landscape of breast cancer.	PPP1R9B ERCC2 PTPN14 EGFR MCU STOM	3.12e-05	634	34	6	34591612
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	GREB1L CKAP5 SIN3B CEP131 SPDL1	5.11e-05	418	34	5	34709266
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	CEP131 MYO1E CWC27 SPTY2D1 SIL1 STOM	8.15e-05	754	34	6	33060197
Pubmed	CDK7/GRP78 signaling axis contributes to tumor growth and metastasis in osteosarcoma.	CKAP5 ERCC2 TMED10 CORO1C SIL1	8.71e-05	468	34	5	36042349
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	CKAP5 SIN3B PTPN14 STOM	1.24e-04	263	34	4	34702444
Pubmed	UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex.	CKAP5 CORO1C MCU SPDL1	1.31e-04	267	34	4	33417871
Pubmed	Systematic Determination of Human Cyclin Dependent Kinase (CDK)-9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the DEAD Box (DDX)-5/17 RNA Helicases.	CKAP5 PPP1R9B MYO1E CORO1C	1.92e-04	295	34	4	26209609
Pubmed	A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.	EVPL CEP131 MYO1E	2.11e-04	118	34	3	30979931
Pubmed	Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage.	ERCC2 EGFR	2.12e-04	22	34	2	24780295
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	CKAP5 EGFR CORO1C STOM SPDL1	2.15e-04	568	34	5	37774976
Pubmed	TRIM37 Mediates Chemoresistance and Maintenance of Stemness in Pancreatic Cancer Cells via Ubiquitination of PTEN and Activation of the AKT-GSK-3β-β-Catenin Signaling Pathway.	PPP1R9B TMED10 MYO1E CORO1C	2.19e-04	305	34	4	33194618
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	CKAP5 TMED10 EGFR SIL1 STOM	3.05e-04	613	34	5	22268729
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CKAP5 SIN3B PPP1R9B CEP131 TMED10 CORO1C	3.07e-04	963	34	6	28671696
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	TMED10 EGFR CWC27 SPTY2D1 SIL1 SPDL1	3.90e-04	1007	34	6	34597346
Pubmed	Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.	DDX47 EVPL TMED10 CORO1C STOM	4.05e-04	652	34	5	31180492
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	DDX47 PPP1R9B EGFR CWC27 CORO1C	4.28e-04	660	34	5	32780723
Pubmed	DNA sequence and analysis of human chromosome 9.	MRPL50 SMC5 STOM SCAI	4.54e-04	370	34	4	15164053
Pubmed	PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.	DDX47 MRPL50 PTPN14 SPTY2D1 CORO1C	4.83e-04	678	34	5	30209976
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	CKAP5 PPP1R9B SMC5 MYO1E CWC27	6.51e-04	724	34	5	36232890
Pubmed	Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.	CKAP5 TMED10 CORO1C STOM	6.55e-04	408	34	4	33766124
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	ZFAND6 CEP131 TMED10 CORO1C SPDL1	6.88e-04	733	34	5	34672954
Pubmed	RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma.	DDX47 PPP1R9B MYO1E	7.61e-04	183	34	3	28186131
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	PPP1R9B SMC5 CORO1C SCAI	7.97e-04	430	34	4	32581705
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	CKAP5 CEP131 PER3 SMC5 CORO1C STOM	8.02e-04	1155	34	6	20360068
Pubmed	The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety.	CORO1C STOM	8.17e-04	43	34	2	26487511
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	PPP1R9B CEP131 PTPN14 CORO1C	9.12e-04	446	34	4	24255178
Pubmed	Mapping the Genetic Landscape of Human Cells.	CKAP5 MRPL50 SMC5 SPDL1	9.51e-04	451	34	4	30033366
Interaction	GPM6B interactions	PPP1R9B EGFR STOM	1.27e-05	28	33	3	int:GPM6B
Interaction	PHLPP1 interactions	CKAP5 SIN3B EGFR CORO1C MCU SPDL1	1.48e-05	333	33	6	int:PHLPP1
Interaction	RTL5 interactions	EGFR RTL5	1.56e-05	4	33	2	int:RTL5
Interaction	PPIAL4F interactions	SMC5 EGFR	2.59e-05	5	33	2	int:PPIAL4F
Interaction	CDC42 interactions	DDX47 PPP1R9B PTPN14 TMED10 MYO1E EGFR CORO1C GRK6 MCU STOM	3.30e-05	1323	33	10	int:CDC42
Interaction	LIMA1 interactions	PPP1R9B PTPN14 MYO1E EGFR CORO1C STOM	6.11e-05	429	33	6	int:LIMA1
Interaction	UQCRC1 interactions	PPP1R9B SMC5 EGFR CORO1C STOM	6.65e-05	265	33	5	int:UQCRC1
Interaction	MYH11 interactions	SECISBP2L PPP1R9B MYO1E SPDL1	6.97e-05	136	33	4	int:MYH11
Interaction	CTTN interactions	CKAP5 PPP1R9B SMC5 MYO1E EGFR CORO1C	7.96e-05	450	33	6	int:CTTN
Interaction	ELF3 interactions	EGFR CORO1C CECR2	9.37e-05	54	33	3	int:ELF3
Interaction	CCNYL1 interactions	CKAP5 EVPL EGFR	1.35e-04	61	33	3	int:CCNYL1
Interaction	AIFM3 interactions	AIFM3 GRK6	1.42e-04	11	33	2	int:AIFM3
Interaction	CHMP4B interactions	CKAP5 DDX47 PPP1R9B MYO1E EGFR CORO1C STOM	1.45e-04	727	33	7	int:CHMP4B
Interaction	DYNLL1 interactions	SECISBP2L CKAP5 PPP1R9B CEP131 SMC5 SPDL1	1.58e-04	510	33	6	int:DYNLL1
Interaction	RHOU interactions	DDX47 MYO1E EGFR GRK6 MCU STOM	1.58e-04	510	33	6	int:RHOU
Interaction	PPP1CC interactions	SECISBP2L SIN3B PPP1R9B SMC5 MYO1E EGFR CORO1C	1.59e-04	738	33	7	int:PPP1CC
Interaction	SCYL1 interactions	TMED10 EGFR CWC27 SPTY2D1	1.62e-04	169	33	4	int:SCYL1
Interaction	CCDC85A interactions	CEP131 GRK6 SCAI	1.63e-04	65	33	3	int:CCDC85A
Interaction	WAPL interactions	CKAP5 DDX47 SMC5 EGFR	1.77e-04	173	33	4	int:WAPL
Interaction	SIPA1L1 interactions	PPP1R9B PTPN14 CWC27 SPDL1	1.81e-04	174	33	4	int:SIPA1L1
Interaction	MYH9 interactions	PPP1R9B SMC5 MYO1E EGFR CORO1C STOM SPDL1	1.82e-04	754	33	7	int:MYH9
Interaction	H2BC5 interactions	SECISBP2L CKAP5 SMC5 MYO1E SPDL1	1.89e-04	331	33	5	int:H2BC5
Interaction	CCDC50 interactions	SMC5 EGFR SPDL1	1.95e-04	69	33	3	int:CCDC50
Interaction	ANO5 interactions	ANO5 EGFR	2.01e-04	13	33	2	int:ANO5
Interaction	NUDC interactions	CKAP5 ANKRD30B EGFR CORO1C GRK6	2.05e-04	337	33	5	int:NUDC
Interaction	HNRNPU interactions	CKAP5 DDX47 MRPL50 PPP1R9B SMC5 EGFR CWC27 SPDL1	2.07e-04	1035	33	8	int:HNRNPU
Interaction	CTNNA2 interactions	PPP1R9B PTPN14 EGFR	2.12e-04	71	33	3	int:CTNNA2
Interaction	PHB2 interactions	PPP1R9B SMC5 EGFR CORO1C MCU STOM	2.15e-04	540	33	6	int:PHB2
Interaction	IRAG2 interactions	CORO1C SPDL1	2.34e-04	14	33	2	int:IRAG2
Interaction	RPS10-NUDT3 interactions	SMC5 EGFR	2.34e-04	14	33	2	int:RPS10-NUDT3
Interaction	TUBB4B interactions	CKAP5 PPP1R9B CEP131 SMC5 EGFR SPDL1	2.62e-04	560	33	6	int:TUBB4B
Interaction	MT-CO2 interactions	EGFR CORO1C MCU STOM	2.85e-04	196	33	4	int:MT-CO2
Interaction	ADNP interactions	SMC5 EGFR GRK6 SCAI	3.02e-04	199	33	4	int:ADNP
Interaction	NIPBL interactions	CKAP5 DDX47 SMC5 EGFR	3.02e-04	199	33	4	int:NIPBL
Interaction	CEND1 interactions	PPP1R9B EGFR	3.08e-04	16	33	2	int:CEND1
Interaction	TBCK interactions	PPP1R9B EGFR CORO1C	3.24e-04	82	33	3	int:TBCK
Interaction	RHOB interactions	DDX47 PTPN14 MYO1E EGFR CORO1C MCU STOM	3.52e-04	840	33	7	int:RHOB
Interaction	SNRPD3 interactions	CKAP5 SMC5 EGFR CWC27 SPDL1	3.57e-04	380	33	5	int:SNRPD3
Interaction	COPS4 interactions	PPP1R9B PTPN14 SMC5 EGFR	3.57e-04	208	33	4	int:COPS4
Cytoband	17q21.33	PPP1R9B ANKRD40CL	4.29e-04	41	34	2	17q21.33
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-Zbtb32+_B\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1E CECR2 GRK6 MCU	1.00e-05	178	34	4	9b932b677ae05ac6e12cd6ce97789f8c10e4790b
ToppCell	Bronchial-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SECISBP2L EGFR CECR2 SCAI	1.55e-05	199	34	4	5f7da3eab58ace6cddb3179a415cd839d5767958
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	EGFR CECR2 MCU SCAI	1.55e-05	199	34	4	8587bd98de7767a575088afbea07a1feb4516b9b
Drug	Picotamide monohydrate [80530-63-8]; Down 200; 10.2uM; PC3; HT_HG-U133A	SECISBP2L SIN3B CEP131 ERCC2 GRK6 STOM	4.53e-07	199	34	6	7140_DN
Disease	Parkinson's disease (biomarker_via_orthology)	PPP1R9B GRK6	4.27e-04	30	30	2	DOID:14330 (biomarker_via_orthology)
Disease	schizophrenia (is_marker_for)	PPP1R9B EGFR	9.21e-04	44	30	2	DOID:5419 (is_marker_for)
Disease	idiopathic pulmonary fibrosis	PTPN14 SPDL1	1.54e-03	57	30	2	EFO_0000768
Disease	Alzheimer's disease (is_marker_for)	PPP1R9B ERCC2 TMED10	2.23e-03	257	30	3	DOID:10652 (is_marker_for)
Disease	cardiomyopathy (implicated_via_orthology)	EGFR MCU	2.38e-03	71	30	2	DOID:0050700 (implicated_via_orthology)
Disease	Dermatologic disorders	ZFAND6 ERCC2	2.65e-03	75	30	2	C0037274
Disease	neuroimaging measurement, brain volume measurement	PPP1R9B EGFR SCAI	3.01e-03	286	30	3	EFO_0004346, EFO_0006930

Protein segments in the cluster

Peptide	Gene	Start	Entry
TEVDKILKVIPRDRK	DDX47	186	Q9H0S4
VDILKEKIRPEEQLR	ANKRD30B	1026	Q9BXX2
EKIRPEEQLRKKLEV	ANKRD30B	1031	Q9BXX2
DVPKDVVERIKREKL	ANO5	856	Q75V66
FDDIIPREIKRLKKE	CWC27	171	Q6UX04
VELKIEVVLPEKERG	AIFM3	11	Q96NN9
ELGIKPERVEKIRKL	ANKRD40CL	46	Q53H64
KKVRVIDPRKQEIVA	CORO1C	196	Q9ULV4
PVLTRIEKQKRKEEE	CECR2	321	Q9BXF3
PLEKVRIEISRKAEK	MCU	216	Q8NE86
VPERVKEVVLKEDLE	PER3	1121	P56645
REVDVKEKVVVKEVV	EVPL	1066	Q92817
LERRKPEEKVVVQEV	EVPL	1361	Q92817
TVPEIEKVIEELRKL	ERCC2	76	P18074
VIKESKVEEPRKRET	GREB1L	1411	Q9C091
EKVKIPVAIKELREA	EGFR	736	P00533
VKVGEPKDVIRKDVR	CKAP5	1296	Q14008
IKKPDLRIIEQEEKI	CCDC168	6256	Q8NDH2
KIKREEVERLVKEVP	GRK6	391	P43250
KKIKEVTVRGLEPEI	CEP131	701	Q9UPN4
ILECVEIERKVRVPK	RTL5	301	Q5HYW3
RKEKEPVVVETVEEK	MRPL50	31	Q8N5N7
RKVTPERLKNIEKEI	PUS7L	351	Q9H0K6
VKERVKKEPVKERPV	PTPN14	816	Q15678
EETVEVPVLKKRREV	SPDL1	441	Q96EA4
AVPVVLKRLKAKEEE	SIN3B	566	O75182
EVKRLFRPIEELKKD	SIL1	156	Q9H173
RPTALKKVILKEREE	SECISBP2L	571	Q93073
FEPVEIKVVKKSEER	SPTY2D1	181	Q68D10
GIKVERVEIKDVKLP	STOM	186	P27105
VEKLKPLEVELRRLE	TMED10	141	P49755
EKIRKENPVVVGEKI	ZFAND6	191	Q6FIF0
VNKEDRPELVVKKLR	SCAI	166	Q8N9R8
RVKEEVRKLKEGQIP	SMC5	291	Q8IY18
GLVKEVLKRKIEIER	MYO1E	806	Q12965
KPREVRKIKPVEVEE	PPP1R9B	291	Q96SB3