Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PNPLA2 RHBDF1 MFHAS1 ATP13A2 RNF43 REXO1 TNRC18 PIK3C2B ZNF341 GLI1 SCN5A TMEM132A HELZ2 ZNF398	3.86e-06	1105	101	14	35748872
Pubmed	A common genetic variant within SCN10A modulates cardiac SCN5A expression.	SCN5A SCN10A	8.35e-06	2	101	2	24642470
Pubmed	Tumor-specific expression of the RGD-alpha3(IV)NC1 domain suppresses endothelial tube formation and tumor growth in mice.	COL4A3 TERT	8.35e-06	2	101	2	16877525
Pubmed	Novel isoforms of the sodium channels Nav1.8 and Nav1.5 are produced by a conserved mechanism in mouse and rat.	SCN5A SCN10A	8.35e-06	2	101	2	15047701
Pubmed	Positive feedback-loop of telomerase reverse transcriptase and 15-lipoxygenase-2 promotes pulmonary hypertension.	TERT ALOX15B	8.35e-06	2	101	2	24376652
Pubmed	Human enhancer of filamentation 1-induced colorectal cancer cell migration: Role of serine phosphorylation and interaction with the breast cancer anti-estrogen resistance 3 protein.	NEDD9 BCAR3	8.35e-06	2	101	2	25817040
Pubmed	Mutations in SCN10A are responsible for a large fraction of cases of Brugada syndrome.	SCN5A SCN10A	8.35e-06	2	101	2	24998131
Pubmed	From GWAS to function: genetic variation in sodium channel gene enhancer influences electrical patterning.	SCN5A SCN10A	8.35e-06	2	101	2	24360055
Pubmed	Single nucleotide polymorphisms of SCN5A and SCN10A genes increase the risk of ventricular arrhythmias during myocardial infarction.	SCN5A SCN10A	8.35e-06	2	101	2	32330377
Pubmed	Structural insights into the association between BCAR3 and Cas family members, an atypical complex implicated in anti-oestrogen resistance.	NEDD9 BCAR3	8.35e-06	2	101	2	19103205
Pubmed	Elastase-2, a Tissue Alternative Pathway for Angiotensin II Generation, Plays a Role in Circulatory Sympathovagal Balance in Mice.	CELA2A CELA2B	8.35e-06	2	101	2	28386233
Pubmed	TERT and Akt Are Involved in the Par-4-Dependent Apoptosis of Islet β Cells in Type 2 Diabetes.	F2RL3 TERT	8.35e-06	2	101	2	30186877
Pubmed	Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans.	CELA2A CELA2B	8.35e-06	2	101	2	16327289
Pubmed	Comparable clinical characteristics in Brugada syndrome patients harboring SCN5A or novel SCN10A variants.	SCN5A SCN10A	8.35e-06	2	101	2	31292628
Pubmed	Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas.	CELA2A CELA2B	8.35e-06	2	101	2	3646943
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	COL4A3 RELN CELA2A LAMA3 CELA2B PLXNA2	1.27e-05	175	101	6	28071719
Pubmed	Plexins promote Hedgehog signaling through their cytoplasmic GAP activity.	GLI1 PLXNA2	2.50e-05	3	101	2	36169302
Pubmed	High prevalence of concealed Brugada syndrome in patients with atrioventricular nodal reentrant tachycardia.	SCN5A SCN10A	2.50e-05	3	101	2	25998140
Pubmed	Human telomerase reverse transcriptase (hTERT) synergistic with Sp1 upregulate Gli1 expression and increase gastric cancer invasion and metastasis.	TERT GLI1	2.50e-05	3	101	2	34601664
Pubmed	The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42.	NEDD9 BCAR3	2.50e-05	3	101	2	12517963
Pubmed	Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA.	CELA2A CELA2B	2.50e-05	3	101	2	3427074
Pubmed	Genome-wide association studies of the PR interval in African Americans.	SCN5A SCN10A	4.99e-05	4	101	2	21347284
Pubmed	MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins.	HM13 UBE2J2	4.99e-05	4	101	2	29519897
Pubmed	Calcium regulates FGF-23 expression in bone.	COL4A3 GCM2	4.99e-05	4	101	2	24140714
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	TRIOBP PTPN23 UBR5 ARHGEF10 HELZ2 RNF10	5.21e-05	225	101	6	12168954
Pubmed	A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.	RELN GCM2 F2RL3 BCORL1 TNRC18 POLR3B METAP2	5.31e-05	331	101	7	19490893
Pubmed	Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers.	F2RL3 F5	8.30e-05	5	101	2	17438064
Pubmed	Risk factors and genetics of atrial fibrillation.	LAMA3 SCN5A	8.30e-05	5	101	2	25443231
Pubmed	Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk.	SCN5A SCN10A	8.30e-05	5	101	2	23463857
Pubmed	Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.	SCN5A SCN10A	8.30e-05	5	101	2	23872634
Pubmed	Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing.	CELA2A CELA2B	8.30e-05	5	101	2	20179351
Pubmed	Heparin rescues factor V Leiden-associated placental failure independent of anticoagulation in a murine high-risk pregnancy model.	F2RL3 F5	8.30e-05	5	101	2	23325830
Pubmed	HIV-1 Vpr protein inhibits telomerase activity via the EDD-DDB1-VPRBP E3 ligase complex.	TERT UBR5	8.30e-05	5	101	2	23612978
Pubmed	Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer.	SCN5A SCN10A	8.30e-05	5	101	2	22706305
Pubmed	Pyramidal neuron subtype diversity governs microglia states in the neocortex.	RELN FEZF2	8.30e-05	5	101	2	35948630
Pubmed	Structural plasticity underpins promiscuous binding of the prosurvival protein A1.	BCL2A1 BBC3	8.30e-05	5	101	2	18462686
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ZNF821 RELN ZBTB38 FEZF2 TRIOBP PAICS RNF123 POLR3B ARHGEF10 RNF10 MRPL38 METAP2 MTUS2	9.00e-05	1285	101	13	35914814
Pubmed	A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis.	CRLF1 LAMA3 NEDD9 GLI1	9.85e-05	82	101	4	30728831
Pubmed	Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation.	TERT UBR5	1.24e-04	6	101	2	23362280
Pubmed	A novel subfamily of mouse cytosolic carboxypeptidases.	AGBL3 AGBL1	1.24e-04	6	101	2	17244818
Pubmed	Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice.	F2RL3 F5	1.24e-04	6	101	2	26341257
Pubmed	Use of a Conditional Ubr5 Mutant Allele to Investigate the Role of an N-End Rule Ubiquitin-Protein Ligase in Hedgehog Signalling and Embryonic Limb Development.	UBR5 GLI1	1.24e-04	6	101	2	27299863
Pubmed	The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids.	AGBL3 AGBL1	1.24e-04	6	101	2	25103237
Pubmed	The carboxypeptidase-like substrate-binding site in Nna1 is essential for the rescue of the Purkinje cell degeneration (pcd) phenotype.	AGBL3 AGBL1	1.24e-04	6	101	2	16952463
Pubmed	The DNA-binding activity of transcription factor PTF1 parallels the synthesis of pancreas-specific mRNAs during mouse development.	CELA2A CELA2B	1.74e-04	7	101	2	2294404
Pubmed	Sequence organisation and transcriptional regulation of the mouse elastase II and trypsin genes.	CELA2A CELA2B	1.74e-04	7	101	2	3641189
Pubmed	Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.	SCN5A SCN10A	1.74e-04	7	101	2	23139255
Pubmed	Gcm1, a mammalian homolog of Drosophila glial cells missing.	GCM2 GLI1	2.31e-04	8	101	2	8814290
Pubmed	Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity.	AGBL3 AGBL1	2.97e-04	9	101	2	26829768
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN5A SCN10A	2.97e-04	9	101	2	16382098
Pubmed	Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP.	ZBTB38 MFHAS1	2.97e-04	9	101	2	22210626
Pubmed	Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders.	RELN ZNF711	2.97e-04	9	101	2	31691806
Pubmed	Genetic predisposition to thrombophilia in inflammatory bowel disease.	CYP7A1 F5	3.70e-04	10	101	2	20717043
Pubmed	Developmental expression of Smoc1 and Smoc2 suggests potential roles in fetal gonad and reproductive tract differentiation.	SMOC1 GLI1	3.70e-04	10	101	2	19842175
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	F2RL3 CELA2A SLFN5 PLD3 SLC7A6 NEDD9 HAVCR2 MFAP4 DPEP2 AURKAIP1 LRRN4 ALOX15B	3.75e-04	1293	101	12	15342556
Pubmed	Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling.	RELN GLI1	4.51e-04	11	101	2	19103804
Pubmed	The global gene-expression profiles of U-937 human macrophages treated with Tat peptide and Tat-FITC conjugate.	HIC1 CRLF1 PAICS	4.74e-04	52	101	3	22632162
Pubmed	Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.	ZBTB38 TERT	5.41e-04	12	101	2	21743467
Pubmed	Genome-wide association study of PR interval.	SCN5A SCN10A	5.41e-04	12	101	2	20062060
Pubmed	IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development.	AGBL3 AGBL1	5.41e-04	12	101	2	28794449
Pubmed	Cis-regulatory control of corticospinal system development and evolution.	RELN FEZF2	6.38e-04	13	101	2	22678282
Pubmed	SOX5 postmitotically regulates migration, postmigratory differentiation, and projections of subplate and deep-layer neocortical neurons.	RELN FEZF2	6.38e-04	13	101	2	18840685
Pubmed	Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members.	BCL2A1 BBC3	6.38e-04	13	101	2	16697956
Pubmed	Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.	BCL2A1 BBC3	6.38e-04	13	101	2	17289999
Pubmed	A physical map of the mouse shaker-2 region contains many of the genes commonly deleted in Smith-Magenis syndrome (del17p11.2p11.2).	MFAP4 MYO15A	6.38e-04	13	101	2	10049592
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN5A SCN10A	6.38e-04	13	101	2	15123669
Pubmed	Several common variants modulate heart rate, PR interval and QRS duration.	SCN5A SCN10A	7.43e-04	14	101	2	20062063
Pubmed	Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth.	TRIOBP MYO15A	7.43e-04	14	101	2	26754646
Pubmed	The DNA sequence and comparative analysis of human chromosome 20.	SNX21 HM13 WFDC13 ZNF341 HELZ2 LRRN4 TCFL5	7.96e-04	517	101	7	11780052
Pubmed	SOX5 controls the sequential generation of distinct corticofugal neuron subtypes.	RELN FEZF2	8.55e-04	15	101	2	18215621
Pubmed	Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.	BCL2A1 BBC3	8.55e-04	15	101	2	15694340
Pubmed	A role for smoothened during murine lens and cornea development.	GLI1 FOXE3	8.55e-04	15	101	2	25268479
Pubmed	Dynamic expression of chymotrypsin-like elastase 1 over the course of murine lung development.	CELA2A CELA2B	8.55e-04	15	101	2	24793170
Pubmed	RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells.	TRIOBP MYO15A	8.55e-04	15	101	2	36260679
Pubmed	Pax6 mediates ß-catenin signaling for self-renewal and neurogenesis by neocortical radial glial stem cells.	RELN FEZF2	8.55e-04	15	101	2	24115331
Pubmed	A single-cell atlas of mouse lung development.	COL4A3 LAMA3	8.55e-04	15	101	2	34927678
Pubmed	Localization of basement membrane-associated protein isoforms during development of the ocular surface of mouse eye.	COL4A3 LAMA3	8.55e-04	15	101	2	9264260
Pubmed	Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.	SCN5A SCN10A	9.76e-04	16	101	2	25035420
Pubmed	GLI3 repressor but not GLI3 activator is essential for mouse eye patterning and morphogenesis.	SMOC1 FOXE3	9.76e-04	16	101	2	30953627
Pubmed	The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas.	CELA2A CELA2B	9.76e-04	16	101	2	9851981
Pubmed	Epithelial cells supply Sonic Hedgehog to the perinatal dentate gyrus via transport by platelets.	RELN GLI1	9.76e-04	16	101	2	26457609
Pubmed	Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development.	LAMA3 GLI1	9.76e-04	16	101	2	12533516
Pubmed	Expression of the semaphorins Sema 3D and Sema 3F in the developing parathyroid and thymus.	GCM2 PLXNA2	9.76e-04	16	101	2	18489001
Pubmed	Pdk1 activity controls proliferation, survival, and growth of developing pancreatic cells.	CELA2A CELA2B	9.76e-04	16	101	2	19635472
Pubmed	Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in the forebrain.	RELN FEZF2	9.76e-04	16	101	2	20431123
Pubmed	A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.	UBE2J2 UBR5	9.76e-04	16	101	2	22496338
Pubmed	Runx2-Twist1 interaction coordinates cranial neural crest guidance of soft palate myogenesis.	TBX22 HIC1	9.76e-04	16	101	2	33482080
Pubmed	Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.	RELN PLXNA2	1.10e-03	17	101	2	11683995
Pubmed	Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.	SCN5A SCN10A	1.10e-03	17	101	2	21076409
Pubmed	Sorting out the cellular functions of sorting nexins.	SNX21 SNX22	1.10e-03	17	101	2	12461558
Pubmed	TP63 gain-of-function mutations cause premature ovarian insufficiency by inducing oocyte apoptosis.	CGB2 BBC3	1.10e-03	17	101	2	36856110
Pubmed	Genetic determinants of P wave duration and PR segment.	SCN5A SCN10A	1.10e-03	17	101	2	24850809
Pubmed	TMEM79/MATTRIN defines a pathway for Frizzled regulation and is required for Xenopus embryogenesis.	NWD1 UBR5	1.24e-03	18	101	2	32924931
Pubmed	An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo.	SCN5A SCN10A	1.24e-03	18	101	2	31666509
Pubmed	A census of human transcription factors: function, expression and evolution.	TBX22 HIC1 ZBTB38 GCM2 ZNF711 GLI1 ZNF398 TCFL5 FOXE3	1.33e-03	908	101	9	19274049
Pubmed	Long QT Syndrome Overview	KCNJ5 SCN5A	1.38e-03	19	101	2	20301308
Pubmed	alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway.	RELN GLI1	1.38e-03	19	101	2	16543460
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ISLR2 NDUFS7 FEZF2 RNF43 ZNF711 UBR5 SCN5A BRD1 DNA2 AGBL1	1.53e-03	1116	101	10	31753913
Pubmed	Neuronal production and precursor proliferation defects in the neocortex of mice with loss of function in the canonical Wnt signaling pathway.	RELN FEZF2	1.53e-03	20	101	2	16920270
Pubmed	Transcriptome-based systematic identification of extracellular matrix proteins.	COL4A3 LAMA3 SMOC1	1.60e-03	79	101	3	18757743
GeneFamily	Myosins, class XV\|Deafness associated genes\|FERM domain containing	MYO15B MYO15A	1.84e-05	2	78	2	1105
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN5A SCN10A	6.49e-04	9	78	2	1203
GeneFamily	UPF1 like RNA helicases	HELZ2 DNA2	9.85e-04	11	78	2	1169
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	FRMPD2 MYO15B MYO15A	1.31e-03	50	78	3	1293
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	BCL2A1 F5 LRG1 STPG2 SCN10A MYO15A AGBL1	3.14e-07	195	101	7	d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	BCL2A1 F5 LRG1 STPG2 SCN10A MYO15A AGBL1	3.14e-07	195	101	7	19853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCell	facs-Lung-nan-3m-Epithelial-type_I_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A3 CRLF1 LAMA3 WDR27 RNF43 SH3RF3	2.19e-06	166	101	6	11b0ae82b3068ef91715dbdd49fe8e9791b4a480
ToppCell	facs-Lung-nan-3m-Epithelial-Alveolar_Epithelial_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A3 CRLF1 LAMA3 WDR27 RNF43 SH3RF3	2.19e-06	166	101	6	fcc1aec31ebd39432d4cb284dc8fadf34e3c566a
ToppCell	Basal\|World / shred by cell class for mouse tongue	LAMA3 SLC7A6 PAICS NEDD9 TMEM132A PLXNA2	3.84e-06	183	101	6	c6729a207526ff4aa48176207b9353176f631fea
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_ALM_Hpgd\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TBX22 PAPPA2 FEZF2 LRG1 TCFL5	1.02e-05	126	101	5	9b04ca8a46cc30119baf6ef27711a0b2a6b4a0c9
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	RHBDF1 LAMA3 TNRC18 ADGRF3 LRRN4	1.37e-05	134	101	5	72d7eec3aeb43319f3ef81bb5518fae8d8880136
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Sema3e-Excitatory_Neuron.Sc17a7.Sema3e-Onecut2_(Layer_6)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ASB17 F2RL3 MYO15B MYO15A	1.74e-05	68	101	4	5af7170acc5e4503375d84472d538e7f5dc92e1d
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6b\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PAPPA2 ISLR2 FEZF2 KCNJ5 SCN10A	1.75e-05	141	101	5	5ef3166c5271aa90fd0633016edfe2c74b835319
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Sema3e\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ASB17 F2RL3 MYO15B MYO15A	2.31e-05	73	101	4	51bcbb57ee6c45cad88cb3e2cedab2cf3503b2a5
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ISLR2 RELN LAMA3 F5 CPNE7	2.93e-05	157	101	5	a426c54fd1545093d41426e9620862f71bd06f6b
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	RELN NWD1 NUP210L AGBL1 MTUS2	3.12e-05	159	101	5	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	droplet-Lung-nan-18m-Myeloid-intermediate_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLFN5 TERT HAVCR2 DPEP2 DNA2	3.72e-05	165	101	5	e32697321cef424c2ad4e11ee9da3e510d5ce505
ToppCell	droplet-Lung-nan-18m-Myeloid-Intermediate_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLFN5 TERT HAVCR2 DPEP2 DNA2	3.72e-05	165	101	5	0fbdd043e11aa8dbff4cd3a4da1b2feb49878a09
ToppCell	facs-Lung-3m-Epithelial-alveolar_epithelial-type_I_pneumocyte\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL4A3 CRLF1 LAMA3 RNF43 SH3RF3	3.94e-05	167	101	5	bebc2493a2ee41920b21c2b774a1c5a9619315c4
ToppCell	facs-Lung-3m-Epithelial-alveolar_epithelial-type_I_pneumocyte-type_1_alveolar_epithelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL4A3 CRLF1 LAMA3 RNF43 SH3RF3	3.94e-05	167	101	5	9f2661729a2d58e17a9203a563d538c08a3dbbbc
ToppCell	Bronchial_Biopsy-Endothelial-Lymphatic\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	ISLR2 RELN F2RL3 SMOC1 DPEP2	4.54e-05	172	101	5	c41f5a66781bbf63afce7ca5d118cc6d8e0fe0bc
ToppCell	Endothelial-Endothelial-G\|Endothelial / shred on cell class and cell subclass (v4)	RELN LRG1 MYO15B DPEP2 CPNE7	4.54e-05	172	101	5	644f8e42ee8d8996f6ae50cdf874559be55509fc
ToppCell	droplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_28\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ISLR2 NUP210L SLFN5 LRG1 PLXNA2	4.66e-05	173	101	5	66488d01e03264fb193285470901c9c4182fbae8
ToppCell	Multiple_Sclerosis-Lymphocyte-T_NK-ILC\|Multiple_Sclerosis / Disease, Lineage and Cell Type	AGBL3 RNF123 POLR3B MRPL38 ZNF319	4.79e-05	174	101	5	7c50bf9da37711266cc077eef4e54b58463f1d37
ToppCell	facs-Lung-Endomucin-24m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN NWD1 LRG1 SCN5A CPNE7	5.06e-05	176	101	5	057d2759fdc67176c25802b57a78064d8cc93205
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN NWD1 LRG1 SCN5A CPNE7	5.06e-05	176	101	5	b81e5d23b31cefc8d374ef403e21acc390c14a80
ToppCell	droplet-Spleen-nan-18m-Hematologic-erythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIC1 CELA2A RNF123 RNF10	5.27e-05	90	101	4	85e5280b5b7d79fed3d356070843a26b50af944b
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL4A3 RELN LAMA3 SMOC1 CPNE7	5.63e-05	180	101	5	c6030e725e3d86d5d74a1676330c77ffeceb324f
ToppCell	Endothelial-B-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	RELN SLC25A21 F2RL3 SMOC1 DNA2	5.78e-05	181	101	5	4fe0215d08f03d4e24749d70fce01b7aa22906fd
ToppCell	E12.5-Epithelial-epithelial_progenitor_cell-epi_progenitor\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CRLF1 LAMA3 RNF43 NEDD9 SNX22	6.09e-05	183	101	5	031b4ffd95114dc10d2932c67d2cfef139b3fd2e
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN LRG1 SCN5A LRRN4 ZNF319	6.41e-05	185	101	5	bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	RHBDF1 HAVCR2 TNRC18 BCAR3	6.51e-05	95	101	4	3d6b97576ce4e7a3e495cbc7246ea8c0b2a386f7
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL4A3 ISLR2 RHBDF1 SMOC1 GLI1	6.74e-05	187	101	5	ed7ab4cf4629d96dad5c74d536fc428d0a8d4eb9
ToppCell	COVID-19_Convalescent-Classical_Monocyte-cMono_3\|Classical_Monocyte / Disease condition and Cell class	FTSJ1 LRG1 REXO1 HAVCR2 SNX22	7.09e-05	189	101	5	8b6f92ccfffc743c07201bc971b3dc1a6fa14ccc
ToppCell	facs-Thymus-Epithelium-24m-Epithelial\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAPPA2 CELA2A LAMA3 HHATL ALOX15B	7.45e-05	191	101	5	eec14997d2bfc7e6b5a601afc43a147f6b96d668
ToppCell	facs-Thymus-Epithelium-24m-Epithelial-TECs\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAPPA2 CELA2A LAMA3 HHATL ALOX15B	7.45e-05	191	101	5	1730ec5dc1cfd2f0cba7e21555641c7bce97e09d
ToppCell	facs-Thymus-Epithelium-24m-Epithelial-epithelial_cell_of_thymus\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAPPA2 CELA2A LAMA3 HHATL ALOX15B	7.45e-05	191	101	5	4b77abc68bd72c64e7062f9527fe9d9605289ceb
ToppCell	COVID-19-Endothelial_cells-Inflamed_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	F2RL3 ARHGEF10 BCAR3 SH3RF3 PLXNA2	7.82e-05	193	101	5	979ebefa527f86bebeea5d94e626ee6c1cc7d53b
ToppCell	control-Myeloid-Neutrophils_3\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	PNPLA2 BCL2A1 F5 LRG1 RNF10	8.02e-05	194	101	5	2218e6677dc6781a6e4ef3a315f2298cc2cd9df2
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL4A3 LAMA3 NEDD9 LRRN4 SNX22	8.21e-05	195	101	5	68f4cc84b5ae7f4159b780c78e4b66c94211779a
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL4A3 LAMA3 NEDD9 LRRN4 SNX22	8.21e-05	195	101	5	2a1863f4b9fe73c30b0b1acf9b12fc98ef65040f
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HHATL KCNJ5 SCN5A SCN10A MTUS2	8.41e-05	196	101	5	a582130862bee76c0385156a333bfdfc75cf218b
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HHATL KCNJ5 SCN5A SCN10A MTUS2	8.41e-05	196	101	5	fba52a4b82086dbae9a55038bf44c4539be926f5
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL4A3 LAMA3 NEDD9 LRRN4 SNX22	8.41e-05	196	101	5	eb68f7954e7c2f86d05e740e95b6e74805a6053f
ToppCell	LPS_only-Epithelial_alveolar\|LPS_only / Treatment groups by lineage, cell group, cell type	LAMA3 LRG1 RNF43 NEDD9 AKAP1	8.83e-05	198	101	5	655df75b9692d815c7f6910275e1f684ac63bf62
ToppCell	LPS_only-Epithelial_alveolar-AT_1-2_Progenitor-Progenitor_AT1-AT2\|LPS_only / Treatment groups by lineage, cell group, cell type	LAMA3 LRG1 RNF43 NEDD9 AKAP1	9.04e-05	199	101	5	0447f8f53389fe7c6ddc04a97d86e74122ea16f4
ToppCell	MS-Multiple_Sclerosis-Lymphocyte-T/NK-ILC\|Multiple_Sclerosis / Disease, condition lineage and cell class	AGBL3 RNF123 POLR3B MRPL38 ZNF319	9.25e-05	200	101	5	ab9bdc9365cbdffe4ed246ce0c8a008a390e387e
ToppCell	Biopsy_IPF-Epithelial-KRT5-/KRT17+\|Biopsy_IPF / Sample group, Lineage and Cell type	COL4A3 CRLF1 SMOC1 TMEM132A BBC3	9.25e-05	200	101	5	2fc7a3b3aea711ad3d96fd9513f4b40533056d86
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_aerocyte_capillary-EC_aerocyte_capillary_L.2.0.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	F2RL3 NEDD9 ARHGEF10 BCAR3 PLXNA2	9.25e-05	200	101	5	16a70cc07dcfb4eba4385b712f27010c6629ff67
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL4A3 LAMA3 AGBL1 MTUS2	1.07e-04	108	101	4	d620f07243c2628494e689bbfabc14c453f4b1f4
Disease	Romano-Ward Syndrome	KCNJ5 SCN5A SCN10A	1.99e-05	16	99	3	C0035828
Disease	Brugada ECG Pattern	SCN5A SCN10A	6.66e-05	4	99	2	C1721096
Disease	Heart Block	KCNJ5 SCN10A	6.66e-05	4	99	2	C0018794
Disease	Auriculo-Ventricular Dissociation	KCNJ5 SCN10A	6.66e-05	4	99	2	C0004331
Disease	gallbladder carcinoma (is_implicated_in)	TERT UBR5	1.11e-04	5	99	2	DOID:4948 (is_implicated_in)
Disease	central nervous system cancer	PAPPA2 TERT POLR3B	1.54e-04	31	99	3	EFO_0000326
Disease	Sick Sinus Syndrome	KCNJ5 SCN5A	1.66e-04	6	99	2	C0037052
Disease	Iron deficiency anemia	F5 RNF43	1.66e-04	6	99	2	HP_0001891
Disease	electrocardiography, PR interval	SCN5A SCN10A	2.31e-04	7	99	2	EFO_0004327, EFO_0004462
Disease	hippocampal CA4 volume	NUP210L TMEM132A ZNF398	3.56e-04	41	99	3	EFO_0009396
Disease	glioblastoma multiforme	TERT POLR3B	3.95e-04	9	99	2	EFO_0000519
Disease	supraventricular ectopy	SCN5A SCN10A	3.95e-04	9	99	2	EFO_0009277
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN5A SCN10A	4.93e-04	10	99	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN5A SCN10A	4.93e-04	10	99	2	DOID:0080422 (implicated_via_orthology)
Disease	pneumonia	F5 NEDD9 HELZ2	5.34e-04	47	99	3	EFO_0003106
Disease	gastric adenocarcinoma (is_implicated_in)	RNF43 UBR5	6.01e-04	11	99	2	DOID:3717 (is_implicated_in)
Disease	Congenital long QT syndrome	KCNJ5 SCN5A	6.01e-04	11	99	2	cv:C1141890
Disease	lung adenocarcinoma (is_implicated_in)	TERT RNF43 UBR5	6.03e-04	49	99	3	DOID:3910 (is_implicated_in)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN5A SCN10A	7.20e-04	12	99	2	DOID:0060170 (implicated_via_orthology)
Disease	Long QT syndrome	KCNJ5 SCN5A	7.20e-04	12	99	2	cv:C0023976
Disease	Mental Retardation, X-Linked Nonsyndromic	FTSJ1 ZNF711	8.48e-04	13	99	2	C3501611
Disease	Brugada Syndrome 1	SCN5A SCN10A	8.48e-04	13	99	2	C4551804
Disease	central nervous system cancer, glioblastoma multiforme	RHBDF1 TERT	9.88e-04	14	99	2	EFO_0000326, EFO_0000519
Disease	T wave morphology measurement	SCN5A SCN10A	9.88e-04	14	99	2	EFO_0008398
Disease	P wave duration	SCN5A SCN10A	1.14e-03	15	99	2	EFO_0005094
Disease	Sinus Node Dysfunction (disorder)	KCNJ5 SCN10A	1.14e-03	15	99	2	C0428908
Disease	Polyposis, Adenomatous Intestinal	F5 LRG1	1.30e-03	16	99	2	C2713442
Disease	Familial Intestinal Polyposis	F5 LRG1	1.30e-03	16	99	2	C2713443
Disease	Adenomatous Polyposis Coli	F5 LRG1	1.47e-03	17	99	2	C0032580
Disease	resting heart rate	COL4A3 KCNJ5 SCN5A SCN10A	1.62e-03	149	99	4	EFO_0004351
Disease	prion disease	ZBTB38 MFHAS1	1.84e-03	19	99	2	EFO_0004720
Disease	Brugada syndrome	SCN5A SCN10A	1.84e-03	19	99	2	MONDO_0015263
Disease	bipolar disorder (is_marker_for)	RELN NDUFS7	1.84e-03	19	99	2	DOID:3312 (is_marker_for)
Disease	brain connectivity measurement	MFHAS1 TRIOBP SH3RF3 METAP2 MTUS2 PLXNA2	2.32e-03	400	99	6	EFO_0005210
Disease	otosclerosis	RELN MFHAS1 SLC7A6	2.59e-03	81	99	3	EFO_0004213
Disease	partial thromboplastin time	F5 AGBL1	2.93e-03	24	99	2	EFO_0004310
Disease	Brugada Syndrome (disorder)	SCN5A SCN10A	2.93e-03	24	99	2	C1142166
Disease	prostate carcinoma	SLC25A21 ZBTB38 TERT RNF43 NEDD9 PIK3C2B ZNF341 DPEP2 MTMR9	3.08e-03	891	99	9	EFO_0001663

Protein segments in the cluster

Peptide	Gene	Start	Entry
PTLLPAAYLCAPTAP	BBC3	51	Q9BXH1
LSPAAVQVGIAPYPV	FAM222A	136	Q5U5X8
CAVLPTVCAPYIPPQ	BRD1	441	O95696
CYSQPGIPTLPTPVE	AKAP1	746	Q92667
EPGYCQLLPPGSPVT	ADGRF3	216	Q8IZF5
TPSCPEPVYIPTGLE	AGBL3	106	Q8NEM8
VPVPCGYAVPSNLPL	ARHGEF10	151	O15013
CQPPAEIPGYLPADT	LRG1	56	P02750
IPPTKGVYAIPPSAC	NEDD9	216	Q14511
EPGLLCTQCPYIPGP	COL4A3	471	Q01955
YLPIGCKLPPQSSGV	BCAR3	341	O75815
YIPPPSCGQPLSVAT	BCORL1	451	Q5H9F3
TLASYPAPQEVPGPC	APBA3	196	O96018
YLQCVLQIPQPGSGP	BCL2A1	16	Q16548
CLPPAGTILPNNYPC	CELA2A	141	P08217
KPPNSTVGEICLPYP	C7orf31	131	Q8N865
AYAFPVPGCITTEPP	AGBL1	281	Q96MI9
CASPPALQGVPVYRL	ISLR2	211	Q6UXK2
ALQGVPVYRLPALPC	ISLR2	216	Q6UXK2
FQVCLAYGLPLPPAQ	NWD1	391	Q149M9
SLVPVGLPYAPPTCT	MTUS2	661	Q5JR59
GLSPYCPPLVATQAP	PTPN23	1251	Q9H3S7
LLQYLPSPPLLGGCA	KCNJ5	376	P48544
TVPSPQVPPRGCYVA	LRRC3C	41	A6NJW4
QGPQPVPGEIKYRTC	SLC25A21	236	Q9BQT8
GFIPVYCGLIPPSLQ	PNPLA2	146	Q96AD5
TPALAYLASAPPPLC	PLD3	286	Q8IV08
PPQPPKCITALYVFA	HHATL	321	Q9HCP6
VQTDPPSVPICDLYP	METAP2	111	P50579
PSVPICDLYPNGVFP	METAP2	116	P50579
CATYALSPVVLPPQP	MAGEC3	26	Q8TD91
PQPELYCKLVGGPTA	LAMA3	76	Q16787
VALVYPPTPTVISPC	MFHAS1	1026	Q9Y4C4
EFAVCPSYPPIVTVP	MTMR9	151	Q96QG7
LQPLEPPRVGYSAGC	MYO15A	2896	Q9UKN7
ATPVIQACYPSPVGP	HIC1	181	Q14526
FTPVYCPSPLSGITP	ASB17	136	Q8WXJ9
VAGVPCTPLPGEYII	PLXNA2	896	O75051
YPPPEGQVCNPLDSL	GLI1	1026	P08151
QPALLYLVPACIGFP	HM13	316	Q8TCT9
GLCVKSGPVVPPNYS	PCDHGB5	726	Q9Y5G0
GPYCVPVVPLPSILK	RELN	1791	P78509
CATLYALPIPPPGSS	PIK3C2B	706	O00750
SILPAPRGYPGQVCA	F2RL3	41	Q96RI0
VYFIQCLTPNPGKLP	MYO15B	226	Q96JP2
YGIGAVCSPLCVIPP	PAPPA2	1671	Q9BXP8
RLPGCPRGVNPVVSY	CGB2	86	Q6NT52
PVLKTALPEGLGPYC	ATP13A2	351	Q9NQ11
CLPPAGTILPNNYPC	CELA2B	141	P08218
APPLYCPQPAILSEE	CPLANE1	1156	Q9H799
CPPSPPEISAGEIYF	FRMPD2	936	Q68DX3
CLPRVQLYGPTNVAP	CPNE7	476	Q9UBL6
LLQPVTCAYTTPGPP	DPEP2	26	Q9H4A9
EPPLENGLIPYLGCA	CYP7A1	31	P22680
PDPCPVPYGSLQLAE	HELZ2	1766	Q9BYK8
GSCLYVGLPPEKPVN	CRLF1	126	O75462
LILLGCVPSLNCYPP	DNA2	1011	P51530
PCMIPLQPLGYEVPS	FEZF2	71	Q8TBJ5
YNQLAALPPCTGPAL	LRRN4	131	Q8WUT4
TPVYKVPAGAQPCPL	NUP210L	766	Q5VU65
LLYQSPGCGPLLPLA	ALOX15B	316	O15296
AVPPARPPTAQEVCY	REXO1	681	Q8N1G1
CGQAPLDPVYLPAAL	TMEM132A	36	Q24JP5
ASCPPGLYQTVPPEE	F5	1111	P12259
LPCFYTPAAPGNLVP	HAVCR2	36	Q8TDQ0
CRYLTTPPPGAPALQ	GCM2	366	O75603
PPCAAAASPPLYSQV	FOXE3	251	Q13461
LIYPSGPSVPVPVFC	MFAP4	56	P55083
STETPPPLYVGPCQL	RHBDF1	136	Q96CC6
LPETPGPCYSNSQPV	RNF43	711	Q68DV7
LLSPILNTGPPYCDP	SCN5A	1716	Q14524
PGCPPTAEALLYGIL	NDUFS7	181	O75251
LQLPAPVCIGYRDAP	TRIOBP	1106	Q9H2D6
TAGTVAPPQSYQCPP	AURKAIP1	91	Q9NWT8
SCPNILEPPPAYTAA	C15orf62	91	A8K5M9
GNTAYPVISCPPLTP	PAICS	341	P22234
PPDYKIQCAEPSPAL	TNRC18	2281	O15417
IVIPECAPGGLYKPV	SMOC1	246	Q9H4F8
LEVPNQCVEPPVYPT	ZNF341	246	Q9BYN7
AEGQVTCPYLPPFPA	MRPL38	246	Q96DV4
LLSPILNTGPPYCDP	SCN10A	1666	Q9Y5Y9
GFLPASYIQCIQPLP	SH3RF3	241	Q8TEJ3
GMPCPEAYLPNVNLP	TBX22	356	Q9Y458
ICYLLGQPEPPAPGT	RNF123	1186	Q5XPI4
PGPAAYNPVLRKSCP	STPG2	401	Q8N412
EVPSCPICLYPPTAA	RNF10	221	Q8N5U6
SYPLPPPVGEQVFSC	ZNF398	331	Q8TD17
YTLAVIGPGPPDCQP	SNX21	151	Q969T3
KDPVPYICAEPLPSN	UBE2J2	26	Q8N2K1
PFTLLGVCAGLIPYP	POLR3B	661	Q9NW08
PYVCNPSPESLPNVV	SNX22	146	Q96L94
IIQPSFPSCDPPYLA	SLC7A6	151	Q92536
TQPPISPPYQEACTL	FTSJ1	266	Q9UET6
LPPGTAENPLGCAVY	ZNF319	36	Q9P2F9
SPPVYPAGILLVCNN	ZNF821	226	O75541
GPPAAEVPPLVYNCS	ZBTB38	331	Q8NAP3
EAYPVECAVPTKPGP	WDR27	491	A2RRH5
VIIGPDGQPLTVYPC	ZNF711	371	Q9Y462
GAAPVYPVLCPSALA	TCFL5	101	Q9UL49
PGVAPPAGAYNLLLC	SLFN5	861	Q08AF3
LVAPSCAYQVCGPPL	TERT	161	O14746
YILEPPPCISAPENC	WFDC13	31	Q8IUB5
RPGLLVPANAPDYCI	ZAR1L	46	A6NP61
FLGCIPPNPFEVPLA	UBR5	2031	O95071