Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
MousePhenopolyhydramnios

ACAN PKD2

2.15e-053382MP:0004020
MousePhenoshort snout

FREM2 NEK1 HIC1 AHDC1 ACAN

3.14e-05136385MP:0000445
MousePhenosmall snout

FREM2 NEK1 HIC1 AHDC1 ACAN

4.13e-05144385MP:0030190
DomainChannel_four-helix_dom

CACNA1A KCNC3 PKD2

3.05e-0457433IPR027359
Domain-

CACNA1A KCNC3 PKD2

3.05e-04574331.20.120.350
Pubmed

Nek1 and TAZ interact to maintain normal levels of polycystin 2.

NEK1 PKD2

5.13e-06346221474562
Pubmed

Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B.

NCOR2 HIC1

1.03e-05446210611298
Pubmed

Analysis of a cAMP regulated coactivator family reveals an alternative phosphorylation motif for AMPK family members.

NEK1 CRTC2

1.03e-05446228235073
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ZNRF1 CUL9 NCOR2 CHD8 TNRC18 RALGAPA2 ZBED3 AHDC1 C6orf132

1.22e-05110546935748872
Pubmed

Sox17 influences the differentiation of respiratory epithelial cells.

SOX17 FOXJ1

1.71e-05546216574095
Pubmed

Murine models of polycystic kidney disease: molecular and therapeutic insights.

NEK1 PKD2

6.12e-05946214600027
Pubmed

Fank1 and Jazf1 promote multiciliated cell differentiation in the mouse airway epithelium.

NR4A3 FOXJ1

9.34e-051146229661797
Pubmed

The Zic2 gene directs the formation and function of node cilia to control cardiac situs.

SOX17 FOXJ1

1.12e-041246224585447
Pubmed

Tbx6 controls left-right asymmetry through regulation of Gdf1.

FOXJ1 PKD2

1.32e-041346229650695
Pubmed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

TNS2 ZSWIM8 PTPRN HNRNPLL AHDC1 GFI1

1.44e-0460846616713569
Pubmed

LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.

CUL9 HELZ NCOR2 ZSWIM8 IARS1 CRTC2

1.88e-0463946623443559
Pubmed

Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource.

CRTC2 ADGRB1

2.88e-041946223912999
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

ZNRF1 HELZ NEK1 TMEM102 IARS1 CRTC2 FOXJ1 PKD2

3.06e-04132146827173435
Pubmed

Global genetic analysis in mice unveils central role for cilia in congenital heart disease.

FREM2 ACAN FOXJ1

3.20e-0410046325807483
Pubmed

Analysis of the asymmetrically expressed Ablim1 locus reveals existence of a lateral plate Nodal-independent left sided signal and an early, left-right independent role for nodal flow.

FKBP1A PKD2

3.20e-042046220487527
Pubmed

cDNAs with long CAG trinucleotide repeats from human brain.

NCOR2 TNRC18

4.25e-04234629225980
Pubmed

Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm.

GFI1 FOXJ1

5.04e-042546215186480
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

NCOR2 CHD8 TNRC18 HNRNPLL AHDC1 GFI1 IARS1

5.75e-04110346734189442
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

CACNA1A HELZ TNRC18 FAM171A2 HNRNPLL IARS1 ADGRB1

6.95e-04113946736417873
Pubmed

14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.

BRSK1 CRTC2

7.27e-043046216306228
Pubmed

STK11 is required for the normal program of ciliated cell differentiation in airways.

BRSK1 FOXJ1

7.77e-043146231636950
Pubmed

TNRC6 proteins modulate hepatitis C virus replication by spatially regulating the binding of miR-122/Ago2 complexes to viral RNA.

HELZ HIC1 HNRNPLL IARS1

8.17e-0431746430997501
Pubmed

The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.

CACNA1A NR4A3

8.80e-043346219336002
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

HELZ NEK1 TMEM102 FAM171A2 C6orf132 CRTC2

9.11e-0486146636931259
Pubmed

A SOX17-PDGFB signaling axis regulates aortic root development.

SOX17 PKD2

9.35e-043446235831318
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

CHD8 TNRC18 AHDC1 IARS1

9.70e-0433246437433992
Pubmed

Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.

NCOR2 ACAN

9.90e-043546219389355
Pubmed

Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.

TNS2 TMPRSS12 BRSK1

1.02e-0314946325184681
Pubmed

Interaction network of human early embryonic transcription factors.

NCOR2 CHD8 TNRC18 AHDC1

1.19e-0335146438297188
Pubmed

A census of human transcription factors: function, expression and evolution.

SOX17 NR4A3 EVX1 HIC1 ZBED3 FOXJ1

1.20e-0390846619274049
GeneFamilyAtaxins|Trinucleotide repeat containing

NCOR2 TNRC18

7.28e-0425292775
ToppCelldroplet-Liver-LIVER-NPC-1m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX17 ZNRF1 FAM171A2 RALGAPA2 FKBP1A

1.72e-06195465126f46dd15dddcf5701144718bb8ba1ce84b2d1d
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CACNA1A TNS2 ACAN ADGRB1

1.98e-0515546477fdae85d36efb776db977eb424b32487ef222e4
ToppCellBAL-Mild-Lymphocyte-T/NK-CD8+_T-MAIT-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZNRF1 HIC1 CD6 BRSK1

2.58e-05166464bb93db4613c067c56614ab1ca39e73ee46484387
ToppCellBAL-Mild-Lymphocyte-T/NK-CD8+_T-MAIT|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZNRF1 HIC1 CD6 BRSK1

2.58e-05166464c1f17a028bb27b8f202bcfffa7de7373b1cdd990
ToppCellmetastatic_Lymph_Node-T/NK_cells-Exhausted_Tfh|metastatic_Lymph_Node / Location, Cell class and cell subclass

ZNRF1 CD6 HNRNPLL GFI1

2.77e-05169464ad9054ee09033b648a76baf1b2ec4a6ab1394bde
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

EMILIN2 HIC1 KCNC3 FKBP1A

3.62e-051814646771f2c72073c59aab905945a619907b7fd0fd77
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NCOR2 NR4A3 FAM171A2 SGCA

4.03e-05186464a558fd00053e7dd6216b01dc8e650c30cee451f1
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic-dendritic_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NCOR2 NR4A3 FAM171A2 SGCA

4.03e-0518646475b1f342be5d6dbe0e7acd924a0ca75964f6bab0
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs-|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NCOR2 NR4A3 FAM171A2 SGCA

4.03e-051864640c3d195077de7b4c354c127a26116438aef29244
ToppCellCF-Lymphoid-T_cell_&_NK_cell|Lymphoid / Disease state, Lineage and Cell class

ZNRF1 CD6 HNRNPLL GFI1

4.20e-0518846415057036b46c9df621ec4955aa94ca3036245d45
ToppCell3'-Pediatric_IBD-SmallIntestine-Hematopoietic-T_cells-Treg|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNRF1 CUL9 CD6 HNRNPLL

4.56e-05192464b7e08cadb50f66c2efdde45e0fa8bab29367269b
ToppCelldroplet-Thymus-nan-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNRF1 CD6 FKBP1A HNRNPLL

4.65e-0519346412380713db6582749183a19de65d4af9d6469a3f
ToppCelldroplet-Liver-LIVER-NPC-1m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX17 FAM171A2 RALGAPA2 FKBP1A

4.84e-05195464f55ab1018a6cde7d517b53e6ce44c3f7bde485c4
ToppCelldroplet-Liver-LIVER-NPC-1m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX17 FAM171A2 RALGAPA2 FKBP1A

4.84e-05195464ea1b00805391dca8be0883b635768b296369919a
ToppCelldroplet-Thymus-nan-21m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNRF1 CD6 FKBP1A HNRNPLL

4.84e-051954642416efe0b10ef28d0107808d1347bc34f87f92b7
ToppCelldroplet-Thymus-nan-21m|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNRF1 CD6 FKBP1A HNRNPLL

4.94e-05196464313d66313d7c93d9ae4c8b790262ba7a85b34fe4
ToppCellBronchial_Biopsy-Mesenchymal-Smooth_muscle|Mesenchymal / Tissue, Lineage and Cell class of Lung Cells from 10X

SOX17 TMEM102 SGCA ACAN

5.04e-0519746498f0184a09563a544f0c2d4df22c9db2fbc95019
Diseaseintracranial aneurysm (is_implicated_in)

SOX17 PKD2

1.49e-0412452DOID:10941 (is_implicated_in)
DiseaseLarge cell carcinoma of lung

NEK1 BRSK1

1.10e-0332452C0345958
DiseaseAtaxia, Spinocerebellar

CACNA1A GFI1

1.24e-0334452C0087012
DiseaseSpinocerebellar Ataxia Type 2

CACNA1A GFI1

1.24e-0334452C0752121
DiseaseSpinocerebellar Ataxia Type 1

CACNA1A GFI1

1.24e-0334452C0752120
DiseaseSpinocerebellar Ataxia Type 5

CACNA1A GFI1

1.24e-0334452C0752123
DiseaseSpinocerebellar Ataxia Type 7

CACNA1A GFI1

1.24e-0334452C0752125
DiseaseSpinocerebellar Ataxia Type 6 (disorder)

CACNA1A GFI1

1.24e-0334452C0752124
DiseaseSpinocerebellar Ataxia Type 4

CACNA1A GFI1

1.31e-0335452C0752122

Protein segments in the cluster

PeptideGeneStartEntry
HVSEGPPGPRHHGYY

CACNA1A

2396

O00555
HHHPGLRAPGYPSSP

CHD8

2506

Q9HCK8
LHLHGSPRYPGGPLP

ADGRB1

1286

O14514
FRHPPLYPGPAHGLG

EVX1

326

P49640
YAYGATGHPGIIPPH

FKBP1A

81

P62942
HGPPGPEGHPKYALR

AHDC1

371

Q5TGY3
AGPGLPGHHSIRPYT

QRICH2

1446

Q9H0J4
FRHDGYGSHGPLLPL

HNRNPLL

286

Q8WVV9
RPHRPRGPIAAHYGG

ODF3B

11

A8MYP8
LPGLHFTPGRGPIHR

CD6

211

P30203
PGHSLAHAYPPGPGL

MMP10

176

P09238
AHAYPPGPGLYGDIH

MMP10

181

P09238
SYAPPGHPLPLGLHD

NCOR2

1076

Q9Y618
HPGHSYGDLPGPSPA

PTPRN

256

Q16849
HPRPHQGSGLGPGTY

LEXM

201

Q3ZCV2
PGVRPGFPYGAAGHH

NEK1

481

Q96PY6
PGHPAALYGPKRAAG

GFI1

161

Q99684
VYHPHGLNHGLGPGP

MUC21

516

Q5SSG8
PPGGHLEGYPCPHLA

HIC1

411

Q14526
GRLFYRHSGPHSPGP

FREM2

651

Q5SZK8
GVKSIPHPGYSHPGH

KLK5

136

Q9Y337
HLVNHLGHYPLSGGP

RALGAPA2

1381

Q2PPJ7
GSPIPYGLGHHPPVT

HELZ

1246

P42694
YGLGHHPPVTIGQPQ

HELZ

1251

P42694
QPHLPGGVVFHYRPG

ACAN

471

P16112
GHPLHPSLNIPYGIR

PRR27

31

Q6MZM9
SPPPPFDHYLGHKGA

FAM171A2

476

A8MVW0
LYVGEPHRGPGLPHG

C6orf132

1066

Q5T0Z8
PGPGLSGLPQHLIHF

C3orf84

116

H3BNL1
ARGPGLPHTHGLPAR

LINC00315

81

P59091
GPGYDAPGLHSPLSH

CRTC2

326

Q53ET0
ALPPGGTDPHGYHQV

FOXJ1

51

Q92949
HLRGLGLYLESHPPP

C16orf90

61

A8MZG2
KEGGGGSPAYHLPHP

BRSK1

6

Q8TDC3
SLLPGRHPYLAHLGP

KIAA1210

16

Q9ULL0
FPHGGVLRLHEPGPQ

CUL9

1826

Q8IWT3
EYHRPPGALHTCGGP

EMILIN2

991

Q9BXX0
PAPSPAGGHHLGYDP

NR4A3

201

Q92570
GPPLLPPHMGGHYRD

SOX17

191

Q9H6I2
GPPFATGLPHYGHIL

IARS1

46

P41252
RSPHHPGFLYGSATP

SGCA

81

Q16586
QPGIGLSPPHYGHYG

SEC24D

16

O94855
YFHLAPGRPGHPSGH

ZBED3

51

Q96IU2
AGHPYGLGPPSLHQG

TNRC18

816

O15417
LGHAPLGPYARGPHY

TMEM102

101

Q8N9M5
DHYSPSGRHRLGPSP

TMPRSS12

21

Q86WS5
SPVGGGDPLHRHLPL

PKD2

166

Q13563
LYPGPGLGHGHSPGL

ZSWIM8

1491

A7E2V4
GLGHGHSPGLHPYTA

ZSWIM8

1496

A7E2V4
PHLGVYPGHRPGLSR

TNS2

576

Q63HR2
PPPGGAPHFGHYRTG

ZNRF1

26

Q8ND25
GAYPAGPHTHPGLLR

KCNC3

611

Q14003