Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	social behavior	KALRN KCNQ2 CHD8	8.50e-05	74	24	3	GO:0035176
GeneOntologyBiologicalProcess	biological process involved in intraspecies interaction between organisms	KALRN KCNQ2 CHD8	9.20e-05	76	24	3	GO:0051703
MousePheno	impaired learning	KALRN KCNQ2 CHD8 EID1	5.95e-05	146	21	4	MP:0012315
Domain	Spectrin	KALRN SYNE1	3.61e-04	23	23	2	PF00435
Domain	Spectrin_repeat	KALRN SYNE1	5.77e-04	29	23	2	IPR002017
Domain	Spectrin/alpha-actinin	KALRN SYNE1	7.04e-04	32	23	2	IPR018159
Domain	SPEC	KALRN SYNE1	7.04e-04	32	23	2	SM00150
Domain	-	PLEKHH1 KALRN RABGAP1	1.18e-02	391	23	3	2.30.29.30
Domain	PH_dom-like	PLEKHH1 KALRN RABGAP1	1.49e-02	426	23	3	IPR011993
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	PCNP SPEN SUPT6H CHD8 BRMS1	1.50e-05	469	24	5	27634302
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	KALRN SUPT6H CHD8 SEPTIN9 UBR4	1.60e-05	475	24	5	31040226
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	PLEKHH1 KALRN SYNE1 UBR4	1.88e-05	233	24	4	37704626
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	POLR1G KALRN SPEN CHD8 SEPTIN9	2.10e-05	503	24	5	16964243
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	PCNP SPEN SUPT6H CHD8	2.51e-05	251	24	4	31076518
Pubmed	The Deubiquitinase USP37 Regulates Chromosome Cohesion and Mitotic Progression.	SPEN CHD8 USP37	2.65e-05	84	24	3	26299517
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	POLR1G PCNP SUPT6H CHD8 RABGAP1 UBR4	5.19e-05	1014	24	6	32416067
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	PLEKHH1 KALRN SPAG9 UBR4	5.30e-05	304	24	4	32235678
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	SPEN SUPT6H CHD8 SPAG9 UBR4	7.26e-05	653	24	5	22586326
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	PCNP SPEN CHD8 UBR4	8.26e-05	341	24	4	32971831
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KALRN SPEN KCNQ2 CHD8 RIC8A UBR4	8.36e-05	1105	24	6	35748872
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	PCNP KALRN KCNQ2 SEPTIN9 RABGAP1 UBR4	9.87e-05	1139	24	6	36417873
Pubmed	The m6A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells.	KALRN UBR4	1.25e-04	24	24	2	35179492
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	KALRN SYNE1 RABGAP1	1.52e-04	151	24	3	17043677
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PLEKHH1 SPEN SYNE1 SEPTIN9	1.63e-04	407	24	4	12693553
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	CHD8 RABGAP1 UBR4 CSTPP1	1.81e-04	418	24	4	34709266
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	PCNP CHD8 SEPTIN9 SPAG9	2.27e-04	444	24	4	34795231
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	SPEN SPAG9 BEND4 UBR4 BRMS1	2.59e-04	857	24	5	25609649
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	PCNP SEPTIN9 RIC8A UBR4	3.52e-04	498	24	4	36634849
Pubmed	Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome.	SUPT6H SEPTIN9	4.05e-04	43	24	2	34672947
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	SYNE1 SPAG9 RABGAP1 UBR4 CSTPP1 C19orf25	4.33e-04	1496	24	6	32877691
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	POLR1G PCNP SPEN SUPT6H CHD8 SYNE1	4.34e-04	1497	24	6	31527615
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	CHD8 SYNE1 SPAG9	4.89e-04	225	24	3	12168954
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	PCNP SPEN CHD8 SPAG9	5.08e-04	549	24	4	38280479
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	PCNP SPAG9 RABGAP1 CSTPP1	5.77e-04	568	24	4	37774976
Pubmed	Multidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT).	PCNP CHD8	6.63e-04	55	24	2	27114453
Pubmed	The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.	SUPT6H UBR4 BRMS1	6.88e-04	253	24	3	29911972
Interaction	HDAC1 interactions	POLR1G SPEN CHD8 SPAG9 RABGAP1 UBR4 CSTPP1 BRMS1 USP37	2.74e-06	1108	24	9	int:HDAC1
Interaction	RCOR1 interactions	SPEN CHD8 SPAG9 RABGAP1 UBR4 CSTPP1	1.95e-05	494	24	6	int:RCOR1
Interaction	H3C1 interactions	POLR1G SPEN CHD8 SYNE1 SPAG9 UBR4 EID1	6.18e-05	901	24	7	int:H3C1
Computational	Genes upregulated in subsets of cells of a given type within various tumors	SPEN SYNE1	1.36e-03	50	12	2	GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_4
Computational	Genes upregulated in subsets of cells of a given type within various tumors	SPEN SPAG9	1.36e-03	50	12	2	GAVISH_3CA_MALIGNANT_METAPROGRAM_4_CHROMATIN
Disease	complement factor H-related protein 3 measurement	KALRN KCNQ2 BEND4	3.42e-04	169	24	3	EFO_0600056
Disease	Malignant neoplasm of breast	KALRN SPEN SYNE1 RIC8A UBR4	1.51e-03	1074	24	5	C0006142
Disease	cystatin C measurement	KALRN SEPTIN9 USP37	4.11e-03	402	24	3	EFO_0004617
Disease	cataract	SEPTIN9 RIC8A	5.84e-03	141	24	2	MONDO_0005129
Disease	intraocular pressure measurement	KALRN SEPTIN9 CSTPP1	7.89e-03	509	24	3	EFO_0004695
Disease	Neoplasm Invasiveness	SEPTIN9 BRMS1	9.75e-03	184	24	2	C0027626
Disease	uterine fibroid	SYNE1 RIC8A	1.13e-02	199	24	2	EFO_0000731

Protein segments in the cluster

Peptide	Gene	Start	Entry
GPPKDQDDEGDPLMM	CHD8	1701	Q9HCK8
EEPPEKRAVLMGPMD	ARID3C	316	A6NKF2
MEEEMQPAEEGPSVP	BEND4	1	Q6ZU67
MGQLGVPPPEMDDRE	QRICH2	251	Q9H0J4
TNGASPVMDKPPEME	SPAG9	861	O60271
PVMDKPPEMEAENSE	SPAG9	866	O60271
DVLMDPPMDDQPGEK	RABGAP1	66	Q9Y3P9
GPMEEEEAQPMAAPE	EID1	56	Q9Y6B2
DEDSEPEEMPPEAKM	PCNP	116	Q8WW12
KGPAEAELPEDPSMM	KCNQ2	606	O43526
PPMKIFDNDPTQDEM	KALRN	1841	O60229
PEPGMEEAGEMEQKQ	PNOC	111	Q13519
KPIMQPTEAEPMEPD	IGSF23	131	A1L1A6
PDKGDLMHDPAMDEE	CSTPP1	256	Q9H6J7
PVPFRMMEDAEAPGE	C19orf25	46	Q9UFG5
PPMVVDDLFEDMKDG	SYNE1	46	Q8NF91
LDTALSPPKEPMDME	SYNE1	6106	Q8NF91
EPGTEAMEPVEPEMK	POLR1G	341	O15446
AMANGMEEKEPEAPE	SEPTIN9	571	Q9UHD8
EEKPPNPMEGMTEEQ	RIC8A	461	Q9NPQ8
MPVQPPSKDTEEMEA	BRMS1	1	Q9HCU9
EEGQEAMEAPMAPPE	SUPT6H	156	Q7KZ85
DLPPGADPDKEAAMM	SPEN	1701	Q96T58
REEPEKMEMEEPPPA	PLEKHH1	371	Q9ULM0
KMEMEEPPPAGKNEE	PLEKHH1	376	Q9ULM0
QEMPENPDTMETEKP	USP37	746	Q86T82
LPQMETEGMDEGKEP	UBR4	2596	Q5T4S7
PPMLDIPPDADDETM	UBR4	2801	Q5T4S7