Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnodal binding

LEFTY2 LEFTY1

1.77e-048512GO:0038100
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

TBC1D10B GAPVD1 CYTH2 CYTH1 HERC2 AGAP9 CYTH4

2.87e-04507517GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

TBC1D10B GAPVD1 CYTH2 CYTH1 HERC2 AGAP9 CYTH4

2.87e-04507517GO:0030695
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

GAPVD1 CYTH2 CYTH1 HERC2 CYTH4

3.02e-04231515GO:0005085
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

MDN1 BMS1 ATP10B DDX20 KIF2A AGAP9 MTREX DNAH8

7.20e-04775518GO:0017111
GeneOntologyMolecularFunctionATP hydrolysis activity

MDN1 ATP10B DDX20 KIF2A MTREX DNAH8

8.71e-04441516GO:0016887
GeneOntologyMolecularFunctionATP-dependent activity

MDN1 MYO5A ATP10B DDX20 KIF2A MTREX DNAH8

8.98e-04614517GO:0140657
GeneOntologyMolecularFunctionGABA-gated chloride ion channel activity

GABRB1 GABRB3

9.53e-0418512GO:0022851
GeneOntologyMolecularFunctionGABA-A receptor activity

GABRB1 GABRB3

1.06e-0319512GO:0004890
GeneOntologyMolecularFunctionpyrophosphatase activity

MDN1 BMS1 ATP10B DDX20 KIF2A AGAP9 MTREX DNAH8

1.20e-03839518GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

MDN1 BMS1 ATP10B DDX20 KIF2A AGAP9 MTREX DNAH8

1.21e-03840518GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

MDN1 BMS1 ATP10B DDX20 KIF2A AGAP9 MTREX DNAH8

1.21e-03840518GO:0016818
GeneOntologyMolecularFunctionGABA receptor activity

GABRB1 GABRB3

1.43e-0322512GO:0016917
GeneOntologyBiologicalProcessnegative regulation of nodal receptor complex assembly

LEFTY2 LEFTY1

5.99e-062512GO:1900124
GeneOntologyBiologicalProcessregulation of nodal receptor complex assembly

LEFTY2 LEFTY1

5.99e-062512GO:1900123
GeneOntologyBiologicalProcessnodal receptor complex assembly

LEFTY2 LEFTY1

5.99e-062512GO:0038099
GeneOntologyBiologicalProcessregulation of ARF protein signal transduction

CYTH2 CYTH1 CYTH4

2.44e-0523513GO:0032012
GeneOntologyBiologicalProcessARF protein signal transduction

CYTH2 CYTH1 CYTH4

2.78e-0524513GO:0032011
GeneOntologyBiologicalProcesssnRNA catabolic process

EXOSC10 MTREX

5.97e-055512GO:0016076
GeneOntologyBiologicalProcessnegative regulation of nodal signaling pathway

LEFTY2 LEFTY1

1.25e-047512GO:1900108
GeneOntologyBiologicalProcesscellular response to histamine

GABRB1 GABRB3

1.25e-047512GO:0071420
GeneOntologyBiologicalProcessregulation of nodal signaling pathway

LEFTY2 LEFTY1

2.13e-049512GO:1900107
GeneOntologyCellularComponentpostsynaptic specialization membrane

GABRB1 GABRB3 ASIC1 CYTH2 SLC12A5

1.28e-04201515GO:0099634
GeneOntologyCellularComponentGemini of coiled bodies

ZPR1 DDX20

3.79e-0412512GO:0097504
MousePhenoabnormal left renal vein morphology

LEFTY2 LEFTY1

7.98e-062402MP:0011327
MousePhenoabnormal renal vein morphology

LEFTY2 LEFTY1

7.98e-062402MP:0011323
MousePhenoabnormal kidney venous blood vessel morphology

LEFTY2 LEFTY1

2.39e-053402MP:0011311
MousePhenoabnormal large intestine placement

LEFTY2 LEFTY1

4.77e-054402MP:0003284
MousePhenoabnormal respiratory conducting tube morphology

LEFTY2 LEFTY1 TRAF4 LOX

7.40e-0579404MP:0004391
MousePhenoabnormal bronchus morphology

LEFTY2 LEFTY1 TRAF4

1.12e-0433403MP:0002264
MousePhenoabsent heart right ventricle

LEFTY2 LEFTY1

1.19e-046402MP:0003872
MousePhenoleft atrial isomerism

LEFTY2 LEFTY1

2.21e-048402MP:0008461
MousePhenoaccessory spleen

LEFTY2 LEFTY1

2.84e-049402MP:0003342
MousePhenotricuspid valve atresia

LEFTY2 LEFTY1

2.84e-049402MP:0006123
MousePhenoabnormal eye blink conditioning behavior

MYO5A ASIC1

3.54e-0410402MP:0002807
MousePhenoincreased circulating potassium level

LEFTY2 KLHL3 LEFTY1 AGAP9

3.84e-04121404MP:0005627
DomainLRDF

LEFTY2 LEFTY1

7.31e-062512IPR003942
Domain-

CYTH2 CYTH1 CYTH4

8.53e-06155131.10.1000.11
DomainSec7

CYTH2 CYTH1 CYTH4

8.53e-0615513PF01369
DomainSec7_alpha_orthog

CYTH2 CYTH1 CYTH4

8.53e-0615513IPR023394
DomainSec7

CYTH2 CYTH1 CYTH4

1.05e-0516513SM00222
DomainSEC7

CYTH2 CYTH1 CYTH4

1.05e-0516513PS50190
DomainSec7_dom

CYTH2 CYTH1 CYTH4

1.05e-0516513IPR000904
DomainGABAAb_rcpt

GABRB1 GABRB3

2.19e-053512IPR002289
DomainBTB-kelch_protein

KLHL3 KLHL2 KLHL23

2.19e-0443513IPR017096
DomainKelch

KLHL3 KLHL2 KLHL23

5.32e-0458513SM00612
DomainGal_Oxase/kelch_b-propeller

KLHL3 KLHL2 KLHL23

5.60e-0459513IPR011043
DomainBACK

KLHL3 KLHL2 KLHL23

5.88e-0460513SM00875
DomainBACK

KLHL3 KLHL2 KLHL23

6.17e-0461513PF07707
DomainBACK

KLHL3 KLHL2 KLHL23

6.17e-0461513IPR011705
DomainATPase_dyneun-rel_AAA

MDN1 DNAH8

6.51e-0414512IPR011704
DomainAAA_5

MDN1 DNAH8

6.51e-0414512PF07728
DomainKelch_1

KLHL3 KLHL2 KLHL23

9.23e-0470513PF01344
DomainKelch_1

KLHL3 KLHL2 KLHL23

9.23e-0470513IPR006652
DomainGABAA/Glycine_rcpt

GABRB1 GABRB3

1.78e-0323512IPR006028
DomainP-loop_NTPase

MDN1 MYO5A BMS1 DDX20 KIF2A AGAP9 MTREX DNAH8

1.96e-03848518IPR027417
Domain-

KLHL3 KLHL2

2.46e-03275122.130.10.80
DomainTGFb_propeptide

LEFTY2 LEFTY1

2.64e-0328512PF00688
DomainTGF-b_N

LEFTY2 LEFTY1

2.64e-0328512IPR001111
DomainTGF-beta-rel

LEFTY2 LEFTY1

3.44e-0332512IPR015615
DomainTGFb_CS

LEFTY2 LEFTY1

3.44e-0332512IPR017948
DomainGal_Oxidase_b-propeller

KLHL3 KLHL2

3.88e-0334512IPR015916
DomainTGFB

LEFTY2 LEFTY1

4.58e-0337512SM00204
DomainTGF-b_C

LEFTY2 LEFTY1

4.58e-0337512IPR001839
DomainTGF_BETA_2

LEFTY2 LEFTY1

4.58e-0337512PS51362
DomainTGF_beta

LEFTY2 LEFTY1

4.58e-0337512PF00019
DomainTGF_BETA_1

LEFTY2 LEFTY1

4.58e-0337512PS00250
DomainBTB

KLHL3 KLHL2 KLHL23

5.49e-03131513PF00651
DomainNeurotransmitter_ion_chnl_CS

GABRB1 GABRB3

6.71e-0345512IPR018000
DomainPH

CYTH2 CYTH1 AGAP9 CYTH4

6.93e-03278514SM00233
DomainNeur_chan_memb

GABRB1 GABRB3

7.01e-0346512PF02932
DomainPH_DOMAIN

CYTH2 CYTH1 AGAP9 CYTH4

7.02e-03279514PS50003
DomainPH_domain

CYTH2 CYTH1 AGAP9 CYTH4

7.11e-03280514IPR001849
DomainNeur_chan_LBD

GABRB1 GABRB3

7.31e-0347512PF02931
DomainNEUROTR_ION_CHANNEL

GABRB1 GABRB3

7.31e-0347512PS00236
DomainNeurotrans-gated_channel_TM

GABRB1 GABRB3

7.31e-0347512IPR006029
Domain-

GABRB1 GABRB3

7.31e-03475122.70.170.10
DomainNeur_channel

GABRB1 GABRB3

7.31e-0347512IPR006201
DomainNeur_chan_lig-bd

GABRB1 GABRB3

7.31e-0347512IPR006202
DomainBTB

KLHL3 KLHL2 KLHL23

9.51e-03160513PS50097
PathwayBIOCARTA_ARAP_PATHWAY

CYTH2 CYTH1 CYTH4

1.51e-0517413M2482
PathwayKEGG_MEDICUS_REFERENCE_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY

CYTH2 CYTH1 CYTH4

5.02e-0525413M47716
PathwayKEGG_MEDICUS_PATHOGEN_SHIGELLA_IPGD_TO_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY

CYTH2 CYTH1 CYTH4

7.92e-0529413M47717
PathwayKEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPB_TO_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY

CYTH2 CYTH1 CYTH4

8.78e-0530413M47738
PathwayREACTOME_INTRA_GOLGI_TRAFFIC

CYTH2 CYTH1 CYTH4

1.66e-0437413MM15354
PathwayWP_MBDNF_AND_PROBDNF_REGULATION_OF_GABA_NEUROTRANSMISSION

GABRB1 GABRB3 SLC12A5

1.79e-0438413M39854
PathwayREACTOME_INTRA_GOLGI_TRAFFIC

CYTH2 CYTH1 CYTH4

2.78e-0444413M27652
PathwayBIOCARTA_ARAP_PATHWAY

CYTH2 CYTH1

5.35e-0412412MM1342
PathwayWP_MIR127_IN_MESENDODERM_DIFFERENTIATION

LEFTY2 LEFTY1

5.35e-0412412MM15910
PathwayREACTOME_REGULATION_OF_SIGNALING_BY_NODAL

LEFTY2 LEFTY1

5.35e-0412412M26952
PathwayWP_2Q37_COPY_NUMBER_VARIATION_SYNDROME

MYO5A CYTH2 CYTH1 CYTH4

8.09e-04145414M45512
PathwayWP_DRAVET_SYNDROME_SCN1AA1783V_POINT_MUTATION_MODEL

GABRB1 GABRB3 SLC12A5

1.23e-0373413MM16641
PathwayREACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION

RNF144B KLHL3 KLHL2 LRR1 HERC2

1.66e-03299415MM15711
PathwayREACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION

RNF144B KLHL3 KLHL2 LRR1 HERC2

1.90e-03308415M1070
PathwayREACTOME_SIGNALING_BY_NODAL

LEFTY2 LEFTY1

2.01e-0323412M511
PathwayREACTOME_MEMBRANE_TRAFFICKING

TBC1D10B GAPVD1 MYO5A CYTH2 CYTH1 KIF2A CYTH4

2.06e-03630417M11480
PathwayREACTOME_INTRA_GOLGI_AND_RETROGRADE_GOLGI_TO_ER_TRAFFIC

CYTH2 CYTH1 KIF2A CYTH4

2.15e-03189414MM15356
Pubmed

Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors.

CYTH2 CYTH1 CYTH4

1.19e-08451310652308
Pubmed

Interaction protein for cytohesin exchange factors 1 (IPCEF1) binds cytohesin 2 and modifies its activity.

CYTH2 CYTH1 CYTH4

2.96e-08551312920129
Pubmed

Notch signaling regulates left-right asymmetry determination by inducing Nodal expression.

LEFTY2 LEFTY1 RBPJ

1.65e-07851312730124
Pubmed

The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane.

CYTH2 CYTH1 CYTH4

1.65e-07851317398095
Pubmed

Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos.

LEFTY2 LEFTY1 RBPJ

2.48e-07951312730123
Pubmed

Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry.

LEFTY2 LEFTY1 RBPJ

1.07e-061451317210915
Pubmed

GABAA receptors involved in sleep and anaesthesia: β1- versus β3-containing assemblies.

GABRB1 GABRB3

2.11e-06251221735059
Pubmed

Lefty antagonises TGF-beta1 induced epithelial-mesenchymal transition in tubular epithelial cells.

LEFTY2 LEFTY1

2.11e-06251220171171
Pubmed

Stra3/lefty, a retinoic acid-inducible novel member of the transforming growth factor-beta superfamily.

LEFTY2 LEFTY1

2.11e-0625129496783
Pubmed

A functional role of LEFTY during progesterone therapy for endometrial carcinoma.

LEFTY2 LEFTY1

2.11e-06251229268772
Pubmed

Cytohesin-1, a cytosolic guanine nucleotide-exchange protein for ADP-ribosylation factor.

CYTH2 CYTH1

2.11e-0625129050849
Pubmed

Anti-inflammatory effects of Lefty-1 in renal tubulointerstitial inflammation via regulation of the NF-κB pathway.

LEFTY2 LEFTY1

2.11e-06251229286065
Pubmed

Epileptic encephalopathy de novo GABRB mutations impair γ-aminobutyric acid type A receptor function.

GABRB1 GABRB3

2.11e-06251226950270
Pubmed

LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-β1/Smad3 pathway.

LEFTY2 LEFTY1

2.11e-06251232745796
Pubmed

Multiple modes for conferring surface expression of homomeric beta1 GABAA receptors.

GABRB1 GABRB3

2.11e-06251218650446
Pubmed

Lefty1 and lefty2 control the balance between self-renewal and pluripotent differentiation of mouse embryonic stem cells.

LEFTY2 LEFTY1

2.11e-06251224147624
Pubmed

Isolation, characterization, and function of EBAF/LEFTY B: role in infertility.

LEFTY2 LEFTY1

2.11e-06251221401636
Pubmed

Lefty1 Ameliorates Post-infarction Fibrosis by Suppressing p-Smad2 and p-ERK1/2 Signaling Pathways.

LEFTY2 LEFTY1

2.11e-06251233409963
Pubmed

LEFTY2 inhibits endometrial receptivity by downregulating Orai1 expression and store-operated Ca2+ entry.

LEFTY2 LEFTY1

2.11e-06251229230527
Pubmed

Exploration of Salmonella effector mutant strains on MTR4 and RRP6 degradation.

EXOSC10 MTREX

2.11e-06251232350160
Pubmed

LEFTY, a member of the transforming growth factor-beta superfamily, inhibits uterine stromal cell differentiation: a novel autocrine role.

LEFTY2 LEFTY1

2.11e-06251220056823
Pubmed

Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development.

LEFTY2 LEFTY1

2.11e-06251210053005
Pubmed

Lefty is expressed in mouse endometrium in estrous cycle and peri-implantation period.

LEFTY2 LEFTY1

2.11e-06251215640253
Pubmed

Mutation analysis of human LEFTY A and LEFTY B genes in children with Ivemark syndrome.

LEFTY2 LEFTY1

2.11e-06251211100524
Pubmed

Molecular analysis of LEFTY-expressing cells in early human embryoid bodies.

LEFTY2 LEFTY1

2.11e-06251217038673
Pubmed

A crucial role for Arf6 in the response of commissural axons to Slit.

CYTH2 CYTH1 CYTH4

2.83e-061951330674481
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

EXOSC10 GAPVD1 MDN1 DNAJC10 IARS1 DDX20 KIF2A MTREX

3.90e-0663851833239621
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

EXOSC10 GAPVD1 MDN1 MYO5A BMS1 DDX20 HERC2 MTREX

4.63e-0665351822586326
Pubmed

Inflammatory Bowel Disease Susceptibility Gene C1ORF106 Regulates Intestinal Epithelial Permeability.

CYTH2 CYTH1

6.32e-06351231022698
Pubmed

Two modes by which Lefty proteins inhibit nodal signaling.

LEFTY2 LEFTY1

6.32e-06351215062104
Pubmed

Nodal and lefty signaling regulates the growth of pancreatic cells.

LEFTY2 LEFTY1

6.32e-06351218393305
Pubmed

Generation of robust left-right asymmetry in the mouse embryo requires a self-enhancement and lateral-inhibition system.

LEFTY2 LEFTY1

6.32e-06351217011489
Pubmed

Lefty-1 inhibits renal epithelial-mesenchymal transition by antagonizing the TGF-β/Smad signaling pathway.

LEFTY2 LEFTY1

6.32e-06351232065356
Pubmed

Lefty-1 alleviates TGF-β1-induced fibroblast-myofibroblast transdifferentiation in NRK-49F cells.

LEFTY2 LEFTY1

6.32e-06351226316705
Pubmed

Histamine action on vertebrate GABAA receptors: direct channel gating and potentiation of GABA responses.

GABRB1 GABRB3

6.32e-06351218281286
Pubmed

Requirements of LEFTY and Nodal overexpression for tumor cell survival under hypoxia in glioblastoma.

LEFTY2 LEFTY1

6.32e-06351233111989
Pubmed

Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule.

CYTH2 CYTH1

6.32e-0635128706128
Pubmed

Role of asymmetric signals in left-right patterning in the mouse.

LEFTY2 LEFTY1

6.32e-06351211471154
Pubmed

Lefty1 alleviates renal tubulointerstitial injury in mice with unilateral ureteral obstruction.

LEFTY2 LEFTY1

6.32e-06351226647776
Pubmed

TGFβ signaling in establishing left-right asymmetry.

LEFTY2 LEFTY1

6.32e-06351224704359
Pubmed

Decidual differentiation of stromal cells promotes Proprotein Convertase 5/6 expression and lefty processing.

LEFTY2 LEFTY1

6.32e-06351216141390
Pubmed

IFT46 plays an essential role in cilia development.

LEFTY2 LEFTY1

6.32e-06351225722189
Pubmed

Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein.

LEFTY2 LEFTY1

6.32e-0635129865700
Pubmed

Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors.

CYTH2 CYTH1

6.32e-06351218042453
Pubmed

Distinct transcriptional regulation and phylogenetic divergence of human LEFTY genes.

LEFTY2 LEFTY1

6.32e-06351210886363
Pubmed

GABAA receptor beta 1, beta 2, and beta 3 subunits: comparisons in DBA/2J and C57BL/6J mice.

GABRB1 GABRB3

6.32e-0635127893750
Pubmed

Nodal activates smad and extracellular signal-regulated kinases 1/2 pathways promoting renal cell carcinoma proliferation.

LEFTY2 LEFTY1

6.32e-06351225672326
Pubmed

Expression and distribution of GABAA receptor subtypes in human alcoholic cerebral cortex.

GABRB1 GABRB3

6.32e-06351211085308
Pubmed

GABAA receptor beta subunit mRNA expression in the human alcoholic brain.

GABRB1 GABRB3

6.32e-06351215337300
Pubmed

Novel Helicobacter species H.japonicum isolated from laboratory mice from Japan induces typhlocolitis and lower bowel carcinoma in C57BL/129 IL10-/- mice.

LEFTY2 LEFTY1

6.32e-06351227655833
Pubmed

Differential expression of GABAA/benzodiazepine receptor beta 1, beta 2, and beta 3 subunit mRNAs in the developing mouse cerebellum.

GABRB1 GABRB3

6.32e-0635121282920
Pubmed

Association of maternal hypertension and diabetes with variants of the NKX2-5, LEFTY1 and LEFTY2 genes in children with congenital heart defects: a case-control study from Pakistani Population.

LEFTY2 LEFTY1

6.32e-06351237097539
Pubmed

Embryonic asymmetry: the left side gets all the best genes.

LEFTY2 LEFTY1

6.32e-0635129889116
Pubmed

Complex regulation of multiple cytohesin-like genes in murine tissues and cells.

CYTH2 CYTH1

6.32e-0635129744817
Pubmed

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.

KLHL2 TBC1D10B TRAF4 GAPVD1 DNAJC10 MYO5A IARS1 CYTH2 CYTH1

7.15e-0692551928986522
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

EXOSC10 GAPVD1 MDN1 IARS1 ZMYM2 KIF2A

9.07e-0633251632786267
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

MDN1 MYO5A ASIC1 CYTH2 CYTH1 ZMYM2 KIF2A HERC2 SLC12A5

9.87e-0696351928671696
Pubmed

Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos.

LEFTY2 LEFTY1

1.26e-0545129348041
Pubmed

Asymmetric Nodal expression in the mouse is governed by the combinatorial activities of two distinct regulatory elements.

LEFTY2 LEFTY1

1.26e-05451215454269
Pubmed

Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry.

LEFTY2 LEFTY1

1.26e-0545129708732
Pubmed

lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal.

LEFTY2 LEFTY1

1.26e-0545129708731
Pubmed

Attenuation of cell adhesion in lymphocytes is regulated by CYTIP, a protein which mediates signal complex sequestration.

CYTH2 CYTH1

1.26e-05451212606567
Pubmed

Nuclear Proximity of Mtr4 to RNA Exosome Restricts DNA Mutational Asymmetry.

EXOSC10 MTREX

1.26e-05451228431250
Pubmed

Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos.

LEFTY2 LEFTY1

1.26e-0545128610011
Pubmed

The dynamic right-to-left translocation of Cerl2 is involved in the regulation and termination of Nodal activity in the mouse node.

LEFTY2 LEFTY1

1.26e-05451223544137
Pubmed

The N-terminal coiled coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with the scaffolding protein CASP.

CYTH2 CYTH1

1.26e-05451212052827
Pubmed

The role of the brachyury gene in heart development and left-right specification in the mouse.

LEFTY2 LEFTY1

1.26e-05451210349618
Pubmed

Calaxin is required for cilia-driven determination of vertebrate laterality.

LEFTY2 LEFTY1

1.26e-05451231240264
Pubmed

Distinct transcriptional regulatory mechanisms underlie left-right asymmetric expression of lefty-1 and lefty-2.

LEFTY2 LEFTY1

1.26e-0545129990851
Pubmed

Specific functional interaction of human cytohesin-1 and ADP-ribosylation factor domain protein (ARD1).

CYTH2 CYTH1

1.26e-05451210748148
Pubmed

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice.

LEFTY2 LEFTY1

1.26e-05451211448943
Pubmed

The anterior visceral endoderm of the mouse embryo is established from both preimplantation precursor cells and by de novo gene expression after implantation.

LEFTY2 LEFTY1

1.26e-05451217662710
Pubmed

The expression pattern of nodal and lefty in the mouse mutant Ft suggests a function in the establishment of handedness.

LEFTY2 LEFTY1

1.26e-0545129376323
Pubmed

Wnt3a-dependent and -independent protein interaction networks of chromatin-bound β-catenin in mouse embryonic stem cells.

LEFTY2 LEFTY1

1.26e-05451223592333
Pubmed

LEFTYA Activates the Epithelial Na+ Channel (ENaC) in Endometrial Cells via Serum and Glucocorticoid Inducible Kinase SGK1.

LEFTY2 LEFTY1

1.26e-05451227606670
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

EXOSC10 MDN1 DNAJC10 MYO5A BMS1 KIF2A HERC2 MTREX

1.38e-0575951835915203
Pubmed

FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.

MDN1 DNAJC10 IARS1 DDX20 HERC2

1.91e-0522351534226595
Pubmed

Lineage-specific functions of TET1 in the postimplantation mouse embryo.

LEFTY2 LEFTY1

2.10e-05551228504700
Pubmed

Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2.

LEFTY2 LEFTY1

2.10e-05551211703930
Pubmed

Cited2 is required both for heart morphogenesis and establishment of the left-right axis in mouse development.

LEFTY2 LEFTY1

2.10e-05551215750185
Pubmed

A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits.

GABRB1 GABRB3

2.10e-05551212595241
Pubmed

Determination of left/right asymmetric expression of nodal by a left side-specific enhancer with sequence similarity to a lefty-2 enhancer.

LEFTY2 LEFTY1

2.10e-05551210385627
Pubmed

Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3.

LEFTY2 LEFTY1

2.10e-05551215308665
Pubmed

Smad5 is essential for left-right asymmetry in mice.

LEFTY2 LEFTY1

2.10e-05551210677256
Pubmed

Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit.

GABRB1 GABRB3

2.10e-0555129039914
Pubmed

The brefeldin A-inhibited GDP/GTP exchange factor 2, a protein involved in vesicular trafficking, interacts with the beta subunits of the GABA receptors.

GABRB1 GABRB3

2.10e-05551215198677
Pubmed

The Nodal inhibitor Lefty is negatively modulated by the microRNA miR-302 in human embryonic stem cells.

LEFTY2 LEFTY1

2.10e-05551221266536
Pubmed

NVL2, a nucleolar AAA-ATPase, is associated with the nuclear exosome and is involved in pre-rRNA processing.

EXOSC10 MTREX

2.10e-05551226166824
Pubmed

Regulation of left-right patterning in mice by growth/differentiation factor-1.

LEFTY2 LEFTY1

2.10e-05551210700179
Pubmed

Mice with mutations in Mahogunin ring finger-1 (Mgrn1) exhibit abnormal patterning of the left-right axis.

LEFTY2 LEFTY1

2.10e-05551217075880
Pubmed

Nodal signaling regulates the entry into meiosis in fetal germ cells.

LEFTY2 LEFTY1

2.10e-05551222396454
Pubmed

Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation.

KLHL3 KLHL2

2.10e-05551224641320
Pubmed

Foxj1 regulates asymmetric gene expression during left-right axis patterning in mice.

LEFTY2 LEFTY1

2.10e-05551215504371
Pubmed

Identification of Four Mouse Diabetes Candidate Genes Altering β-Cell Proliferation.

LEFTY2 LEFTY1

2.10e-05551226348837
Pubmed

Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate.

LEFTY2 LEFTY1

2.10e-05551212642485
Pubmed

NOTCH activation interferes with cell fate specification in the gastrulating mouse embryo.

LEFTY2 LEFTY1 RBPJ

2.82e-054051326534985
Pubmed

Update on the Kelch-like (KLHL) gene family.

KLHL3 KLHL2 KLHL23

3.04e-054151323676014
Pubmed

Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH.

LEFTY2 LEFTY1

3.15e-05651210411502
Pubmed

Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1.

LEFTY2 LEFTY1

3.15e-05651210500184
Pubmed

Tissue-specific requirements for the proprotein convertase furin/SPC1 during embryonic turning and heart looping.

LEFTY2 LEFTY1

3.15e-05651210603343
InteractionIPCEF1 interactions

CYTH2 CYTH1 CYTH4

2.34e-0611503int:IPCEF1
InteractionLEFTY1 interactions

LEFTY2 LEFTY1

3.61e-054502int:LEFTY1
InteractionLEFTY2 interactions

LEFTY2 LEFTY1

3.61e-054502int:LEFTY2
Cytoband1q42.1

LEFTY2 LEFTY1

7.93e-05125121q42.1
GeneFamilyKelch like|BTB domain containing

KLHL3 KLHL2 KLHL23

1.01e-0442393617
GeneFamilyGamma-aminobutyric acid type A receptor subunits

GABRB1 GABRB3

7.58e-0419392563
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

CYTH2 CYTH1 AGAP9 CYTH4

9.85e-04206394682
GeneFamilyBasic leucine zipper proteins|BTB domain containing

KLHL3 KLHL2 KLHL23

2.99e-03134393861
CoexpressionLINDGREN_BLADDER_CANCER_CLUSTER_2A_DN

RNASE4 DNAJC10 MYO5A IARS1 KIF2A

8.08e-06141515M11896
ToppCellcellseq-Immune-Immune_Myeloid-Myeloid_Dendritic-pDC|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TRAF4 INPP4A SIDT1 MPEG1 CYTH4

2.30e-06186515d23c3318937492d7d665bec14253124c49181b5a
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TRAF4 INPP4A SIDT1 MPEG1 CYTH4

2.43e-061885151f820cb19eb0e15f0eb69d07e457072bbdad8ecb
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TRAF4 INPP4A SIDT1 MPEG1 CYTH4

2.56e-06190515c44aae2e0d3cc84a187e12917fd8c2d7483f41d8
ToppCell368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|368C / Donor, Lineage, Cell class and subclass (all cells)

MYO5A RBPJ MPEG1 CYTH4 SLC12A5

2.56e-06190515cbba3d94a4c3e0b0d14f3b7c60dba5d6e097c5e3
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TRAF4 INPP4A SIDT1 MPEG1 CYTH4

2.56e-06190515705489ebbaf3d8e643498c3e507742114475fc55
ToppCellFetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RNF144B MYO5A RBPJ MPEG1 CYTH4

2.62e-0619151524d75b7e1d6fb9d24aa7844f584ee888a449841f
ToppCell367C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|367C / Donor, Lineage, Cell class and subclass (all cells)

MYO5A RBPJ MPEG1 CYTH4 SLC12A5

2.83e-06194515e3688f4252aae5f849f025d7f453ff4c0c14590b
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

RNF144B KLHL2 MYO5A RBPJ CYTH4

2.83e-06194515663e7e7fe48157e808b4f1a0ea6ad41944e857a2
ToppCell367C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

MYO5A RBPJ MPEG1 CYTH4 SLC12A5

2.90e-061955154008fa86b5166087a4b20f89ae07e1dfc87c855d
ToppCellLA-08._Macrophage|LA / Chamber and Cluster_Paper

RNF144B MYO5A CYTH1 RBPJ CYTH4

2.90e-061955155e1d5bdb8874091f5a2b1d0a8cc9008165718a97
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RNF144B MYO5A RBPJ MPEG1 CYTH4

2.98e-06196515cbc727b55b6433a701b1a331028a49960fcee6ee
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular-Interstitial_macrophage_perivascular_L.1.2.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MYO5A RBPJ MPEG1 CYTH4 SLC12A5

3.21e-061995154e552015989defc32fe9068e0ba28521b2a1a09c
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-lung_macrophage|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MYO5A RBPJ MPEG1 CYTH4 SLC12A5

3.21e-0619951542d57522aa05892f37790d0039d936e065565359
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MYO5A RBPJ MPEG1 CYTH4 SLC12A5

3.21e-061995150554f41ae53c275c92fe692bd999d7578d244fce
ToppCellcellseq-Immune-Immune_Myeloid-IM|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MYO5A RBPJ MPEG1 CYTH4 SLC12A5

3.21e-06199515b3267d5a7ae0461f5e9e6a3ab6783317a8c42506
ToppCellcellseq-Immune-Immune_Myeloid-IM-IM|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MYO5A RBPJ MPEG1 CYTH4 SLC12A5

3.21e-0619951501dacee8bb392639d475be3cb27ba3eeff1e57f1
ToppCellParenchyma_Control_(B.)-Immune-TX-MoAM-2|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

MYO5A RBPJ MPEG1 CYTH4 SLC12A5

3.28e-06200515670ef1e68be0d2c6ea20ab4dea1d051a3cc89799
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-epithelial_cell_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO5A MPEG1 CD96 CYTH4

2.99e-051555140e24e767a3895d31d34cabeaca0354aadae34e44
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-Lgr5-_amplifying_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO5A MPEG1 CD96 CYTH4

2.99e-05155514f3489a548a2c0cc2d9117ff85865c6089ea0835d
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RNASE4 MYO5A MPEG1 CYTH4

3.38e-0516051418954241e11309ecb0f3ca87897eadcb20dc8eca
ToppCell368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

MYO5A RBPJ CYTH4 SLC12A5

3.63e-051635144b8abbad4df040c895e3afb240759ebbc66b4d0e
ToppCellPND10-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRR1 MYO5A RBPJ CYTH4

3.63e-051635147af3d3ae7e0de733a18d0486c7ffbb5a7ef7230a
ToppCellDendritic_Cells-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

RBPJ SIDT1 MPEG1 SLC12A5

3.90e-05166514fbeb74b98b58085de323f744b18d4a8f7b22d5d4
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)-D122|Adult / Lineage, Cell type, age group and donor

MYO5A RBPJ MPEG1 CYTH4

3.90e-05166514be284e2e596390f05305c7bcfc316f87b963fc0b
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

INPP4A SIDT1 MPEG1 CYTH4

4.09e-0516851459b698f58cb206f0f8f0e8ad72b445d14ba24728
ToppCellmetastatic_Brain-B_lymphocytes-GrB-secreting_B_cells|metastatic_Brain / Location, Cell class and cell subclass

LRR1 RNASE4 SIDT1 MPEG1

4.18e-0516951471f6761b9927f352e0ccc221ca373319915f4184
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RNASE4 MYO5A MPEG1 CYTH4

4.28e-051705146ec0cf055ae55e9fac147f7989c47f83ab07270c
ToppCelldroplet-Lung-21m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LEFTY1 TRAF4 INPP4A MPEG1

4.38e-051715142dfed6e9ac89adb2501a1a5e1ca895f49190562d
ToppCelldroplet-Lung-21m-Hematologic-myeloid-plasmacytoid_dendritic_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LEFTY1 TRAF4 INPP4A MPEG1

4.38e-051715142aaae0229c3a13d0275a03a3d576db650c2bf2c0
ToppCelldroplet-Lung-18m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LEFTY1 TRAF4 INPP4A MPEG1

4.48e-05172514422d311bba2dd5d8bece4e96ee8c86e78086b62d
ToppCell5'-GW_trimst-2-LymphNode-Hematopoietic-Myeloid-pDC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TRAF4 SIDT1 MPEG1 CYTH4

4.48e-051725143aed10e6db48254f4cae12fbe52d1a1fc6cf2dce
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RNASE4 MYO5A MPEG1 CYTH4

4.48e-05172514c96bd3407911df3e3e6d7a3dba786b11814b9598
ToppCelldroplet-Lung-18m-Hematologic-myeloid-plasmacytoid_dendritic_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LEFTY1 TRAF4 INPP4A MPEG1

4.48e-051725141abb6fbb28c8aff384540493d0f70eeacaa751f4
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RNASE4 MYO5A MPEG1 CYTH4

4.48e-05172514714172f31abd0d25261df6115ec6a9df491fa14b
ToppCelldroplet-Lung-nan-3m-Myeloid-plasmacytoid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GABRB1 LEFTY1 TRAF4 CYTH4

4.58e-051735141b9b4e165121b08ef15a93fca6bea875cae69f19
ToppCelldroplet-Lung-nan-3m-Myeloid-Plasmacytoid_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GABRB1 LEFTY1 TRAF4 CYTH4

4.58e-05173514c25f24d7b672c9686d31ebc8d263042282f520fd
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RNASE4 MYO5A MPEG1 CYTH4

4.69e-051745140a8fa44604be19fbac722ebc6d1cd72b71be7022
ToppCellPND03-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RNASE4 MYO5A MPEG1 CYTH4

4.79e-0517551453e6f1f8dd482dfa2539e068dacefbb6e08443bc
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-IM|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RNASE4 MYO5A MPEG1 CYTH4

4.90e-05176514adb679e69c0c17f0caee4c141bac55d03c963012
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RNASE4 MYO5A MPEG1 CYTH4

5.01e-05177514ab92ffc9624850a50c88e6b8f3a517ff2251ff15
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

INPP4A SIDT1 MPEG1 CYTH4

5.01e-051775148887ff6341eb070bdaa890cc2cd7745f0cf1b0af
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

INPP4A SIDT1 MPEG1 CYTH4

5.01e-05177514507f06d31ab773099c9431b6f433899dc97b5566
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

INPP4A SIDT1 MPEG1 CYTH4

5.23e-05179514c9f45cfea0ceb0cdc31bcfd123aeab69aeb35c35
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TRAF4 INPP4A SIDT1 MPEG1

5.23e-051795144808469096cd6bec2bdfcf4fc55aa324757600c3
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TRAF4 INPP4A SIDT1 MPEG1

5.23e-051795144d55718c6afd8a038d93cc77b9b08171dab9976f
ToppCellfacs-Marrow-B-cells-3m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LEFTY1 INPP4A MPEG1 CYTH4

5.35e-05180514bf8d13d4db1af55b8c9fe16aaccf8743e000e005
ToppCellfacs-Marrow-B-cells-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LEFTY1 INPP4A MPEG1 CYTH4

5.35e-05180514839defb40f7cfb2711e9025194de636533f51bcd
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TRAF4 INPP4A SIDT1 MPEG1

5.35e-051805146a2366d76276452141db1bd93013a9503525f574
ToppCellmoderate-Myeloid-pDC|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

TRAF4 MDN1 INPP4A SIDT1

5.35e-051805141d8df7df03a71f49d6683554d3c948ce90dda42e
ToppCellfacs-Marrow-B-cells-3m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LEFTY1 INPP4A MPEG1 CYTH4

5.35e-0518051482965ed1b72a1873c24dd4553d39681596057316
ToppCellPND03-Immune-Immune_Myeloid-Monocytic-Macrophage-IM|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RNASE4 MYO5A MPEG1 CYTH4

5.35e-05180514a600bc705993d3a010550a25d3b54358946f061f
ToppCellwk_20-22-Hematologic-Myeloid-pDC|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

TRAF4 SIDT1 MPEG1 CYTH4

5.46e-0518151460607c5ff6d5b1cb416adc034491dca31c41e988
ToppCellfacs-Marrow-B-cells-18m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LEFTY1 INPP4A MPEG1 CYTH4

5.46e-05181514782716b8b1d447d2bbe09a693fa5ed7ebeac0efb
ToppCellfacs-Marrow-B-cells-18m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LEFTY1 INPP4A MPEG1 CYTH4

5.46e-05181514e2481291c236105774c53883e6f20da11941df9b
ToppCelltumor_Lung-Myeloid_cells-pDCs|tumor_Lung / Location, Cell class and cell subclass

LRR1 TRAF4 SIDT1 MPEG1

5.46e-05181514c864ffeb9234b8c29754afc91c85a972889617f4
ToppCellnormal_Lung-B_lymphocytes-GrB-secreting_B_cells|normal_Lung / Location, Cell class and cell subclass

TRAF4 INPP4A SIDT1 MPEG1

5.70e-05183514c930b957d16f9b0904b6c424acd914532e5cc137
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

KRT39 ZFTA MUC5B AGAP9

5.95e-05185514ef3c1fd52d21d96f81fb0e5097b24be0ce16e222
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Dendritic-plasmacytoid_dendritic_cell|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

KRT39 ZFTA MUC5B AGAP9

5.95e-05185514c357fa098b561da16c9fa82b0c3563b5cd3fa875
ToppCellFetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RNF144B MYO5A CYTH1 CYTH4

6.33e-051885143be2d50148daa4eddddc2c7f269f45c97f7e4931
ToppCellCOVID-19-Heart-Macrophage|COVID-19 / Disease (COVID-19 only), tissue and cell type

MYO5A RBPJ MPEG1 CYTH4

6.46e-051895142586f4088721c5debec86c2b211b739fd33713eb
ToppCell10x3'2.3-week_14-16-Myeloid_DC-DC-pDC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

TRAF4 SIDT1 MPEG1 CYTH4

7.01e-051935142c35aadc397e7e365c3daf8017ae1d3bd045f305
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)|Adult / Lineage, Cell type, age group and donor

MYO5A RBPJ MPEG1 CYTH4

7.01e-0519351431c0978ba78c9516d498aec0798902e57555e557
ToppCellImmune-interstitial_macrophage_(C1Q_positive)|World / Lineage, Cell type, age group and donor

MYO5A RBPJ MPEG1 CYTH4

7.01e-0519351464d598162a256ac6c9f8280c8a9133661dfbb10f
ToppCellCOVID-19-Heart-Macrophage|Heart / Disease (COVID-19 only), tissue and cell type

MYO5A RBPJ MPEG1 CYTH4

7.15e-05194514f09675cd472200363c458952f00d2e41990800ee
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-B_cell-B_cell-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

KLHL3 SIDT1 DDX20 AGAP9

7.15e-051945149a99abc65e7509e7ae8fb392f5ee4b2a83128072
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MYO5A RBPJ MPEG1 CYTH4

7.15e-0519451448c37251518f96524807b5bd1bbc2820637666ad
ToppCellHippocampus-Neuronal|Hippocampus / BrainAtlas - Mouse McCarroll V32

GABRB3 MYO5A HERC2 SLC12A5

7.15e-051945148aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCellLA-08._Macrophage|World / Chamber and Cluster_Paper

RNF144B MYO5A RBPJ CYTH4

7.15e-05194514c1805572bcc11b1cd29083329d7b5911489fb758
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular-Interstitial_macrophage_perivascular_L.1.2.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MYO5A RBPJ MPEG1 CYTH4

7.15e-051945147b6a34d1f8922b71dcc931421666c1822cec8345
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MYO5A RBPJ MPEG1 CYTH4

7.15e-051945141dce6d4b6ac41f80677e3e4c335a4f383bd76f85
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYO5A RBPJ MPEG1 CYTH4

7.15e-05194514c95d5c4ad0210ebd672926558cc8331e6396a854
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MYO5A RBPJ MPEG1 CYTH4

7.15e-05194514435406ebe626c702f7d5a99a3d68ee85aa09be95
ToppCell368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

RBPJ MPEG1 CYTH4 SLC12A5

7.15e-0519451458046894446cb250814252a23f60fdd59c114d77
ToppCellRA-08._Macrophage|RA / Chamber and Cluster_Paper

RNF144B MYO5A RBPJ CYTH4

7.15e-05194514ac26e5c71d5069622de72fa25a9c920887ac2c19
ToppCellmedial-2-Hematologic-IGSF21+_Dendritic|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RBPJ MPEG1 CYTH4 SLC12A5

7.29e-05195514bb612979360b2322289545dda3d3c343d005ee6f
ToppCellCOVID-19-lung-Macrophage_CD163hi_MERTKhi|lung / Disease (COVID-19 only), tissue and cell type

RNF144B MYO5A RBPJ CYTH4

7.29e-05195514148fff8c3c9ba45ec36e98dff1be57e3f8294506
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

RNF144B MYO5A RBPJ CYTH4

7.29e-05195514247803cf58c6d9c561a52aa34e581188ddad197e
ToppCellBronchial-10x5prime-Immune_Myeloid-Dendritic_cell-DC_plasmacytoid|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

TRAF4 INPP4A SIDT1 MPEG1

7.29e-05195514fbc324c3435f32b9ca269d83333faecfe940d7fe
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MYO5A RBPJ MPEG1 CYTH4

7.29e-0519551442bfdff88da1d07828c0ad65d412fb1752f0cee4
ToppCell(3)_MNP-(3)_Macrophage_MARCOneg|(3)_MNP / Lung cell shreds - cell class (v4) and cell subclass (v4)

MYO5A RBPJ CYTH4 SLC12A5

7.29e-05195514e4b5e4b8832669fb4d1661ecd828b81e621d35c4
ToppCellFetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RNF144B MYO5A MPEG1 CYTH4

7.29e-05195514312d9625655b38f1a7c2bf8f8bb7b667ebdf9617
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-DC-pDC-Z|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

INPP4A SIDT1 MPEG1 CYTH4

7.29e-0519551406051de72b5c1e0d483a28b14dabd247dfca0ed9
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-DC-pDC|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

INPP4A SIDT1 MPEG1 CYTH4

7.29e-051955143aa44633c72658545aa2b35bf9d532c62f36a451
ToppCell343B-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

RBPJ MPEG1 CYTH4 SLC12A5

7.29e-0519551467b05a0cd2ca9924eca81a92cc6330eecb9d963c
ToppCellmedial-Hematologic-IGSF21+_Dendritic-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RBPJ MPEG1 CYTH4 SLC12A5

7.29e-05195514779130c2cfcbc603955b0c0332b855b22ab6e9e6
ToppCellmedial-Hematologic-IGSF21+_Dendritic|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RBPJ MPEG1 CYTH4 SLC12A5

7.29e-05195514330b688d703d53cb7feb29373b5a6e6e529169ec
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MYO5A RBPJ MPEG1 CYTH4

7.29e-0519551434a9462f4e843f3065cc58c17ad71c1b5b836ae1
ToppCelldistal-Hematologic-Plasmacytoid_Dendritic-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TRAF4 SIDT1 MPEG1 CYTH4

7.44e-05196514170629b9ae82e9a911b93e8739dcd38176fbecb4
ToppCellCOVID-19-lung-Macrophage_CD163hi_MERTKhi|COVID-19 / Disease (COVID-19 only), tissue and cell type

RNF144B MYO5A CYTH1 CYTH4

7.44e-051965147026c1fc33425e5476063d17c79e4b79356a9e01
ToppCellParenchymal-10x5prime-Immune_Myeloid-Dendritic_cell-DC_plasmacytoid|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

TRAF4 INPP4A SIDT1 MPEG1

7.44e-05196514b10b386aacc672949560df2dbb0d4f76cf62e213
ToppCell367C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

SIDT1 MPEG1 CYTH4 SLC12A5

7.44e-05196514e8c4eeb4b6c6d9bccca2adb942d4cfbaab39636c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

RNF144B MYO5A RBPJ CYTH4

7.58e-051975148af4a1e35ce9fb4ea3d26ab619599efb7eac43a5
ToppCell(3)_Macrophage_MARCOneg|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

RBPJ MPEG1 CYTH4 SLC12A5

7.58e-05197514b0ee2ce1179b60b4542559acb300a34295277dbc
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RNF144B RBPJ MPEG1 CYTH4

7.58e-051975146ca6e17b7cc5f7ea8d4b6ca1ff670969bee65a45
ToppCellBiopsy_Other_PF-Immune-pDCs|Biopsy_Other_PF / Sample group, Lineage and Cell type

TRAF4 INPP4A SIDT1 MPEG1

7.58e-05197514598a130eb7afb1bb95da64a964218362627feb49
ToppCelldistal-1-Hematologic-Plasmacytoid_Dendritic|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TRAF4 SIDT1 MPEG1 CYTH4

7.58e-05197514166d47359df9279ea8c3946f10bd3d4b88c95857
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MYO5A RBPJ CD96 CYTH4

7.58e-05197514c9b1f2ee7eb31a66af331c5aae29e1bbb5186f5a
ToppCelldistal-Hematologic-IGSF21+_Dendritic|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RBPJ MPEG1 CYTH4 SLC12A5

7.58e-05197514a357ee2ba9100dfaeba9ecae8138a2776bb54b0b
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-ventral_progenitors_and_neurons_1|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

GABRB1 GABRB3 LHX8 SLC12A5

7.58e-051975144961f66606f08e399508fd6cabca588e7ab406a8
ToppCelldistal-Hematologic-IGSF21+_Dendritic-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RBPJ MPEG1 CYTH4 SLC12A5

7.58e-05197514e77c91f5a1f5a292eda41abf3b1e31180f2c61e1
DrugSecinH3

CYTH2 CYTH1 CYTH4

8.81e-079513CID001029232
Drugzaleplon

GABRB1 GABRB3 KY CYTH1

1.73e-0639514CID000005719
DrugDihydrostreptomycin sulfate [5490-27-7]; Down 200; 2.8uM; HL60; HG-U133A

EXOSC10 DNAJC10 MYO5A ASIC1 BMS1 NDUFB7

5.37e-061995161391_DN
Diseaseresponse to methotrexate, juvenile idiopathic arthritis

GABRB3 CYTH4

4.92e-0419512EFO_0002609, GO_0031427
DiseaseHepatic Form of Wilson Disease

LOX NDUFB7

7.89e-0424512C1527352
DiseaseHepatolenticular Degeneration

LOX NDUFB7

7.89e-0424512C0019202
DiseaseCiliopathies

LEFTY2 TTC8 DNAH8

9.22e-04110513C4277690
Diseaseosteoarthritis, hand

RNF144B DNAH8

1.88e-0337512EFO_1000789
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

GABRB1 GABRB3

3.27e-0349512DOID:0060037 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
RRLTIIECGCDINMM

AGAP9

21

Q5VTM2
DRMMEAFATRYCLCN

CYTH4

161

Q9UIA0
TYCCRGEEENMMMRI

DDX20

411

Q9UHI6
RRLTIIECGCDINMM

BMS1

126

Q14692
NRIMAYSRGQTDMCR

ATP10B

1431

O94823
QVDCDRMRGLMCANS

MUC5B

1396

Q9HC84
CMRSEGCRRENTMKN

INPP4A

931

Q96PE3
NVDMGRVMELTYSNC

MPEG1

56

Q2M385
CRVYIERNEGCAQMM

RNF144B

196

Q7Z419
RDGQILVYCLNRMSM

MDN1

2456

Q9NU22
PMTEGTRCCRQEMYI

LEFTY1

256

O75610
TRCCRQEMYIDLQGM

LEFTY1

261

O75610
QEMRCQYEPIMETNR

KRT39

266

Q6A163
TSYCGLVRVDMRMLC

LRR1

161

Q96L50
DHSMNVCMRVELYGC

DDR2

171

Q16832
YVRENIQVGMMVRCC

HERC2

2566

O95714
IQVGMMVRCCRAYEE

HERC2

2571

O95714
LFERMCRLAGVQCMT

KY

231

Q8NBH2
NLMAQLQETMRCVCR

GAPVD1

1176

Q14C86
DRCYITLAQALGMNM

DNAH8

1826

Q96JB1
YNMMVTRRCCSFIAQ

FMO4

231

P31512
IDRMMEAFAQRYCQC

CYTH1

161

Q15438
MQILSRCQGLMSEEC

LHX8

1

Q68G74
CMMDLRRYPLDEQNC

GABRB1

161

P18505
CMMDLRRYPLDEQNC

GABRB3

161

P28472
MMDAQLRLQLRDYCA

NDUFB7

46

P17568
TNPNYEIMCMIRDFR

KIF2A

191

O00139
QGDRLLQCMSRVMQY

EXOSC10

76

Q01780
LQCMSRVMQYHGCRS

EXOSC10

81

Q01780
ERRMECGAVIMNGCI

KLHL23

496

Q8NBE8
DRMMEAFAQRYCLCN

CYTH2

161

Q99418
PMTEGTRCCRQEMYI

LEFTY2

256

O00292
TRCCRQEMYIDLQGM

LEFTY2

261

O00292
MSMYNLRCAAEENCL

LOX

231

P28300
ADMNMCRRNAGVCAV

KLHL3

521

Q9UH77
IGAVNCGDDRMLCRM

DNAJC10

181

Q8IXB1
NNMRVYGTCVLTCMA

SLC12A5

251

Q9H2X9
RYSIIMNRCVCARMA

OR2K2

131

Q8NGT1
CMSEIKNLERYMCSR

TENT5D

251

Q8NEK8
MGITEYNNQCRAIVM

IARS1

111

P41252
TRYLVENCNCRMVHM

ASIC1

316

P78348
TGGSDRYCNLMMQRR

RNASE4

46

P34096
CMNCYCNGMTRLLLT

ZPR1

51

O75312
LCGIARIYEEMNNMS

TTC8

321

Q8TAM2
RNMSCSVSGRYECML

CD96

106

P40200
CMRRLEELLRQMCQA

MTREX

996

P42285
CIQQCSRPLYMDRMV

SIDT1

671

Q9NXL6
RSCQGMYETMEQLRN

TBC1D10B

571

Q4KMP7
YCENKCGARMMRRLL

TRAF4

166

Q9BUZ4
AETMYRCGESMLCVV

RBPJ

391

Q06330
YRMANGLIMNCCEQC

ZMYM2

456

Q9UBW7
YVMQETIRNLDCIRM

ZNF563

31

Q8TA94
MDYDGSRRGLVCMVC

ZFTA

591

C9JLR9
VADMNMCRRNAGVCA

KLHL2

526

O95198
YLQCCFRRMMAKREL

MYO5A

891

Q9Y4I1