Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	monoatomic ion channel activity	LRRC8E CCT8L2 TRPC7 TRPM5 ABCC9 OCA2 OTOP3 PKD1L2	3.52e-04	459	76	8	GO:0005216
GeneOntologyMolecularFunction	histone H3K4 monomethyltransferase activity	KMT2C KMT2D	3.94e-04	8	76	2	GO:0140945
GeneOntologyMolecularFunction	flavin adenine dinucleotide binding	NDOR1 MICAL2 MICAL3 DUS3L	4.56e-04	94	76	4	GO:0050660
GeneOntologyMolecularFunction	FAD binding	NDOR1 MICAL2 MICAL3	6.27e-04	44	76	3	GO:0071949
GeneOntologyMolecularFunction	histone H3K4 trimethyltransferase activity	KMT2C KMT2D	6.31e-04	10	76	2	GO:0140999
GeneOntologyMolecularFunction	channel activity	LRRC8E CCT8L2 TRPC7 TRPM5 ABCC9 OCA2 OTOP3 PKD1L2	8.51e-04	525	76	8	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	LRRC8E CCT8L2 TRPC7 TRPM5 ABCC9 OCA2 OTOP3 PKD1L2	8.62e-04	526	76	8	GO:0022803
GeneOntologyMolecularFunction	NAD(P)H oxidase H2O2-forming activity	DUOX1 MICAL2	9.21e-04	12	76	2	GO:0016174
HumanPheno	Bilateral conductive hearing impairment	KMT2D TELO2 VARS1	6.50e-06	8	26	3	HP:0008513
HumanPheno	Conductive deafness	KMT2D TELO2 VARS1	1.38e-05	10	26	3	HP:0000367
Domain	FYrich_C	KMT2C KMT2D	1.54e-04	5	74	2	IPR003889
Domain	FYrich_N	KMT2C KMT2D	1.54e-04	5	74	2	IPR003888
Domain	FYRC	KMT2C KMT2D	1.54e-04	5	74	2	SM00542
Domain	FYRN	KMT2C KMT2D	1.54e-04	5	74	2	SM00541
Domain	FYRN	KMT2C KMT2D	1.54e-04	5	74	2	PF05964
Domain	FYRC	KMT2C KMT2D	1.54e-04	5	74	2	PF05965
Domain	FYRC	KMT2C KMT2D	1.54e-04	5	74	2	PS51543
Domain	FYRN	KMT2C KMT2D	1.54e-04	5	74	2	PS51542
Domain	FAD-bd	MICAL2 MICAL3	2.30e-04	6	74	2	IPR002938
Domain	FAD_binding_3	MICAL2 MICAL3	2.30e-04	6	74	2	PF01494
Domain	PH-BEACH_dom	WDFY3 WDFY4	4.27e-04	8	74	2	IPR023362
Domain	-	WDFY3 WDFY4	4.27e-04	8	74	2	2.30.29.40
Domain	PH_BEACH	WDFY3 WDFY4	4.27e-04	8	74	2	PS51783
Domain	BEACH_dom	WDFY3 WDFY4	5.48e-04	9	74	2	IPR000409
Domain	BEACH	WDFY3 WDFY4	5.48e-04	9	74	2	PS50197
Domain	Beach	WDFY3 WDFY4	5.48e-04	9	74	2	PF02138
Domain	-	WDFY3 WDFY4	5.48e-04	9	74	2	1.10.1540.10
Domain	Beach	WDFY3 WDFY4	5.48e-04	9	74	2	SM01026
Domain	SET	KMT2C KMT2D SETD6	5.71e-04	41	74	3	PF00856
Domain	SET	KMT2C KMT2D SETD6	8.02e-04	46	74	3	SM00317
Domain	-	VARS1 DALRD3	8.32e-04	11	74	2	1.10.730.10
Domain	SET_dom	KMT2C KMT2D SETD6	1.02e-03	50	74	3	IPR001214
Domain	SET	KMT2C KMT2D SETD6	1.02e-03	50	74	3	PS50280
Domain	Dynein_HC_stalk	DNHD1 DYNC2H1	1.37e-03	14	74	2	IPR024743
Domain	Dynein_heavy_dom-2	DNHD1 DYNC2H1	1.37e-03	14	74	2	IPR013602
Domain	DHC_N2	DNHD1 DYNC2H1	1.37e-03	14	74	2	PF08393
Domain	MT	DNHD1 DYNC2H1	1.37e-03	14	74	2	PF12777
Domain	DHC_fam	DNHD1 DYNC2H1	1.57e-03	15	74	2	IPR026983
Domain	Dynein_heavy_dom	DNHD1 DYNC2H1	1.57e-03	15	74	2	IPR004273
Domain	Dynein_heavy	DNHD1 DYNC2H1	1.57e-03	15	74	2	PF03028
Domain	tRNAsynth_Ia_anticodon-bd	VARS1 DALRD3	1.57e-03	15	74	2	IPR009080
Domain	Post-SET_dom	KMT2C KMT2D	1.79e-03	16	74	2	IPR003616
Domain	PostSET	KMT2C KMT2D	1.79e-03	16	74	2	SM00508
Domain	POST_SET	KMT2C KMT2D	1.79e-03	16	74	2	PS50868
Domain	Fd_Rdtase_FAD-bd	DUOX1 NDOR1	2.54e-03	19	74	2	IPR017927
Domain	FAD_FR	DUOX1 NDOR1	2.54e-03	19	74	2	PS51384
Domain	Riboflavin_synthase-like_b-brl	DUOX1 NDOR1	2.54e-03	19	74	2	IPR017938
Domain	EPHD	KMT2C KMT2D	3.40e-03	22	74	2	PS51805
Domain	CARD	APAF1 CARD10	5.48e-03	28	74	2	PF00619
Domain	CARD	APAF1 CARD10	6.69e-03	31	74	2	IPR001315
Domain	CARD	APAF1 CARD10	7.55e-03	33	74	2	PS50209
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	LRRC8E CPTP KMT2C URB1 INTS5 KMT2D NDOR1 PGAP3 PSME4 CARD10 MICAL3 WDFY3 STK11IP	1.19e-06	1105	79	13	35748872
Pubmed	Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.	KMT2C KMT2D	5.09e-06	2	79	2	28483418
Pubmed	Carnitine palmitoyltransferase-1c gain-of-function in the brain results in postnatal microencephaly.	NDOR1 CPT1C	5.09e-06	2	79	2	21592121
Pubmed	The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape.	KMT2C KMT2D	5.09e-06	2	79	2	34156443
Pubmed	KMT2C/D COMPASS complex-associated diseases [KCDCOM-ADs]: an emerging class of congenital regulopathies.	KMT2C KMT2D	5.09e-06	2	79	2	31924266
Pubmed	Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma.	KMT2C KMT2D	5.09e-06	2	79	2	27280393
Pubmed	Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.	KMT2C KMT2D	5.09e-06	2	79	2	36869380
Pubmed	Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.	KMT2C KMT2D	5.09e-06	2	79	2	28967912
Pubmed	Crucial roles of mixed-lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice.	KMT2C KMT2D	5.09e-06	2	79	2	25346535
Pubmed	Association of KMT2C/D loss-of-function variants with response to immune checkpoint blockades in colorectal cancer.	KMT2C KMT2D	5.09e-06	2	79	2	36601880
Pubmed	Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.	KMT2C KMT2D	1.53e-05	3	79	2	23932714
Pubmed	Dual oxidase 1 induced by Th2 cytokines promotes STAT6 phosphorylation via oxidative inactivation of protein tyrosine phosphatase 1B in human epidermal keratinocytes.	DUOX1 STAT6	1.53e-05	3	79	2	21411736
Pubmed	Mutations of PTCH1, MLL2, and MLL3 are not frequent events in hepatoblastoma.	KMT2C KMT2D	1.53e-05	3	79	2	22183980
Pubmed	HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment.	KMT2C KMT2D	1.53e-05	3	79	2	21683083
Pubmed	Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation.	KMT2C KMT2D	3.05e-05	4	79	2	19221051
Pubmed	Cancer gene mutation frequencies for the U.S. population.	KMT2C KMT2D	3.05e-05	4	79	2	34645806
Pubmed	MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.	KMT2C KMT2D	3.05e-05	4	79	2	28398509
Pubmed	Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice.	KMT2D NDOR1	3.05e-05	4	79	2	23826075
Pubmed	A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.	KMT2C KMT2D	3.05e-05	4	79	2	23129768
Pubmed	Redox modification of nuclear actin by MICAL-2 regulates SRF signaling.	MICAL2 MICAL3	3.05e-05	4	79	2	24440334
Pubmed	The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.	KMT2C KMT2D	3.05e-05	4	79	2	24081332
Pubmed	The MICAL proteins and rab1: a possible link to the cytoskeleton?	MICAL2 MICAL3	3.05e-05	4	79	2	15694364
Pubmed	MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion.	MICAL2 MICAL3	5.07e-05	5	79	2	12110185
Pubmed	Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.	KMT2C KMT2D	5.07e-05	5	79	2	31127101
Pubmed	IL-4 and IL-13 inhibit IL-1β and TNF-α induced kinin B1 and B2 receptors through a STAT6-dependent mechanism.	BDKRB1 STAT6	5.07e-05	5	79	2	23351078
Pubmed	The Taste Receptor TAS1R3 Regulates Small Intestinal Tuft Cell Homeostasis.	TRPM5 STAT6	5.07e-05	5	79	2	31980480
Pubmed	Loss of Jak2 selectively suppresses DC-mediated innate immune response and protects mice from lethal dose of LPS-induced septic shock.	NDOR1 STAT6	5.07e-05	5	79	2	20231889
Pubmed	MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ.	KMT2C KMT2D	5.07e-05	5	79	2	32601106
Pubmed	A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.	KMT2C KMT2D	5.07e-05	5	79	2	26744420
Pubmed	A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.	TRPC7 TRPM5 PKD1L2	5.86e-05	33	79	3	19834762
Pubmed	Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut.	TRPM5 STAT6	7.60e-05	6	79	2	26847546
Pubmed	Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.	KMT2C KMT2D	7.60e-05	6	79	2	17021013
Pubmed	Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.	KMT2C KMT2D	1.06e-04	7	79	2	30604749
Pubmed	Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers.	KMT2C KMT2D	1.06e-04	7	79	2	36598580
Pubmed	ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.	KMT2C KMT2D	1.06e-04	7	79	2	19556342
Pubmed	IL-4/IL-13 signaling beyond JAK/STAT.	FES STAT6	1.06e-04	7	79	2	10856136
Pubmed	Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.	TRPC7 TRPM5 PKD1L2	1.40e-04	44	79	3	19322198
Pubmed	Four enzymes cooperate to displace histone H1 during the first minute of hormonal gene activation.	KMT2C KMT2D	1.41e-04	8	79	2	21447625
Pubmed	H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development.	KMT2C KMT2D	1.41e-04	8	79	2	30335158
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	KMT2C KMT2D	1.41e-04	8	79	2	23130995
Pubmed	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.	KMT2C KMT2D	1.41e-04	8	79	2	22266653
Pubmed	Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.	KMT2C KMT2D	1.82e-04	9	79	2	22665483
Pubmed	Maternal imprinting of the mouse Snrpn gene and conserved linkage homology with the human Prader-Willi syndrome region.	FES OCA2	2.27e-04	10	79	2	1303276
Pubmed	Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis.	NDOR1 STAT6	2.27e-04	10	79	2	36646704
Pubmed	MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.	KMT2C KMT2D	2.76e-04	11	79	2	37012455
Pubmed	Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock.	MPL RFXANK	2.76e-04	11	79	2	22649097
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	NRM NPTN URB1 INTS5 TELO2 DYNC2H1 TIMELESS RTN2 VARS1	2.85e-04	942	79	9	31073040
Pubmed	Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.	KMT2C KMT2D	3.31e-04	12	79	2	27563068
Pubmed	Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.	KMT2C KMT2D	3.91e-04	13	79	2	21502505
Pubmed	Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.	KMT2C KMT2D	3.91e-04	13	79	2	17761849
Pubmed	New murine polymorphisms detected by random amplified polymorphic DNA (RAPD) PCR and mapped by use of recombinant inbred strains.	FES OCA2	4.55e-04	14	79	2	7894156
Pubmed	Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.	KMT2C KMT2D	4.55e-04	14	79	2	12482968
Pubmed	The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.	KMT2C KMT2D	5.25e-04	15	79	2	17925232
Pubmed	H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.	KMT2C KMT2D	5.99e-04	16	79	2	24368734
Pubmed	MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.	KMT2C KMT2D	6.78e-04	17	79	2	26180087
Pubmed	PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.	KMT2C KMT2D	7.61e-04	18	79	2	17500065
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	KMT2C PSME4 DYNC2H1 PKD1L2 VARS1	8.49e-04	322	79	5	26514267
Pubmed	Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.	KMT2C KMT2D	9.43e-04	20	79	2	29785026
Pubmed	¹H NMR metabolic profiling of plasma reveals additional phenotypes in knockout mouse models.	NPTN GPR33	9.43e-04	20	79	2	25849460
Pubmed	Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.	KMT2C KMT2D	9.43e-04	20	79	2	19047629
Pubmed	The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus.	KMT2C KMT2D	9.43e-04	20	79	2	33431871
Pubmed	Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.	LRRC75B PNPLA3	1.04e-03	21	79	2	18940312
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KMT2C KMT2D	1.04e-03	21	79	2	27626377
Pubmed	Structural basis for activity regulation of MLL family methyltransferases.	KMT2C KMT2D	1.14e-03	22	79	2	26886794
Pubmed	Trans-differentiation of outer hair cells into inner hair cells in the absence of INSM1.	NPTN INSM2	1.14e-03	22	79	2	30305733
Pubmed	Mapping the expression of transient receptor potential channels across murine placental development.	TRPC7 TRPM5	1.36e-03	24	79	2	33884443
Pubmed	Gene network analysis in a pediatric cohort identifies novel lung function genes.	MICAL3 OCA2	1.36e-03	24	79	2	24023788
Pubmed	International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.	TRPC7 TRPM5	1.48e-03	25	79	2	16382100
Pubmed	Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice.	DUOX1 KL	1.60e-03	26	79	2	33905568
Pubmed	5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.	HTR6 TELO2	1.72e-03	27	79	2	23027611
Pubmed	An introduction to TRP channels.	TRPC7 TRPM5	1.72e-03	27	79	2	16460286
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	KMT2C URB1 APAF1 WDFY3	1.75e-03	225	79	4	12168954
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	EIF2D INTS5 KMT2D MYO18A MICAL3 TIMELESS CDT1	1.91e-03	774	79	7	15302935
Pubmed	High glucose mediates the ChREBP/p300 transcriptional complex to activate proapoptotic genes Puma and BAX and contributes to intervertebral disc degeneration.	KLK10 PNPLA3	1.99e-03	29	79	2	34461288
Pubmed	Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice.	MYO18A ABCC9	2.13e-03	30	79	2	28077597
Pubmed	Identification and characterization of a novel human PP1 phosphatase complex.	KMT2C KMT2D	2.27e-03	31	79	2	20516061
Cytoband	7q36.1	KMT2C GIMAP1 CCT8L1P	2.91e-04	74	79	3	7q36.1
GeneFamily	WD repeat domain containing\|BEACH domain containing	WDFY3 WDFY4	2.16e-04	9	45	2	1230
GeneFamily	Transient receptor potential cation channels	TRPC7 TRPM5	2.20e-03	28	45	2	249
GeneFamily	WD repeat domain containing\|Caspase recruitment domain containing\|Apoptosome	APAF1 CARD10	2.52e-03	30	45	2	959
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2C KMT2D	3.23e-03	34	45	2	487
GeneFamily	LIM domain containing	MICAL2 MICAL3	9.47e-03	59	45	2	1218
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Proliferating_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESYT3 URB1 TELO2 GPR33 SETD6 TIMELESS CDT1	2.53e-08	173	79	7	15af4a0f7516dbf5c93ba66a19aca073ebe30d04
Disease	Kleefstra syndrome 2 (implicated_via_orthology)	KMT2C KMT2D	6.04e-06	2	73	2	DOID:0080598 (implicated_via_orthology)
Disease	Chediak-Higashi syndrome (implicated_via_orthology)	WDFY3 WDFY4	3.61e-05	4	73	2	DOID:2935 (implicated_via_orthology)
Disease	esophagus squamous cell carcinoma (is_implicated_in)	KMT2C KMT2D FES	1.91e-04	45	73	3	DOID:3748 (is_implicated_in)
Disease	squamous cell carcinoma (is_implicated_in)	KMT2C OCA2	9.00e-04	18	73	2	DOID:1749 (is_implicated_in)
Disease	Chronic myeloproliferative disorder	MPL CDT1	1.00e-03	19	73	2	C1292778
Disease	eotaxin measurement	TELO2 MICAL3 OCA2	1.04e-03	80	73	3	EFO_0008122
Disease	maximal midexpiratory flow rate	MICAL3 OCA2	1.11e-03	20	73	2	EFO_0004313
Disease	nighttime rest measurement	MYO18A HLCS	1.61e-03	24	73	2	EFO_0007827
Disease	body fat percentage, coronary artery disease	DYNC2H1 FES	1.61e-03	24	73	2	EFO_0001645, EFO_0007800
Disease	Sezary Syndrome	KMT2C KMT2D	2.04e-03	27	73	2	C0036920
Disease	1,5 anhydroglucitol measurement	PCDHA7 PKD1L2	2.35e-03	29	73	2	EFO_0008009

Protein segments in the cluster

Peptide	Gene	Start	Entry
IWSFDLLLPLHELRG	APAF1	1111	O14727
GRLHLRLEWLSLLTD	ESYT3	416	A0FGR9
EAWDLLHRVLPTFII	BDKRB1	31	P46663
LASFLPLLLGWHELG	HTR6	156	P50406
PGSERILLDILEHDW	CARD10	311	Q9BWT7
WRLVGLPVHLLFLRF	C6orf136	231	Q5SQH8
LGWLLLEEYQLPRKH	EIF2D	556	P41214
LLHLSGLLERWEGPL	B4GAT1	106	O43505
AIGLDRYLLTLHPVW	GPR33	121	Q49SQ1
LLSELLPDWLSLHRI	CDT1	501	Q9H211
FPGHNLRWILTFALL	ABCC9	66	O60706
LLLIGLQVLHAEWDP	DNHD1	4651	Q96M86
LPELRDWGVALVTLH	DUS3L	451	Q96G46
LGAIWLLILADIHDF	OCA2	656	Q04671
LSWLELLPGGLLESH	DUOX1	476	Q9NRD9
GRHLLLFIIILAAWE	PCDHA7	11	Q9UN72
LFIIEGLHRRPLWET	OTOP3	466	Q7RTS5
VLHLWPFTIHDLRGL	MICAL3	126	Q7RTP6
PARLLNLDLDLWVHL	KMT2C	4416	Q8NEZ4
ILYHLLEDSALRDPW	HLCS	196	P50747
ARGLLWLLEEEALVP	MYO18A	876	Q92614
LLDHLRLSILPWDES	PNPLA3	301	Q9NST1
LVHLLLLARWEDTPL	PEDS1	61	A5PLL7
GLSDELLHLLLPSLW	LRRC75B	191	Q2VPJ9
DRSILAPLAWDLGLL	NRM	56	Q8IXM6
LWVFGLRGLEELHLE	LRRC8E	501	Q6NSJ5
LLGLALLWFPLDSHA	CHRDL2	11	Q6WN34
WHAVREELLLPALAG	INSM2	491	Q96T92
HRLRELGSLVWELLD	NDOR1	526	Q9UHB4
TLFPLGELRSLRLWH	PKD1L2	1446	Q7Z442
LTGLTDRPWLHVLFF	OR5AC2	16	Q9NZP5
LRLLLSYHGWLLEPH	CPT1C	126	Q8TCG5
SPDHWLDLFRLLGLP	DYNC2H1	1206	Q8NCM8
FSPLQSLWEEFLHLL	GSN-AS1	31	Q9NRJ2
CRRELPTFHWFLLEL	FAXDC2	161	Q96IV6
LLGGALLFWVLLHRR	GIMAP1	281	Q8WWP7
GTHLWEFIRDILLNP	EHF	206	Q9NZC4
HWLQLFLEGLRTSPE	CPTP	116	Q5TA50
LIRHLLLNFLLWAPG	FANCC	486	Q00597
QHPFFLALDWAGLLR	MAST3	636	O60307
THFRFSLDWALILPL	KL	591	Q9UEF7
HDEGEWLLLFNSILP	DALRD3	441	Q5D0E6
ALDFPLLLDLLWHLC	FAM30A	111	Q9NZY2
AKGLHIVPRLLFEDW	CHID1	141	Q9BWS9
VLHLWPFTIHDLRGL	MICAL2	126	O94851
RFLLEWGADPHILAK	RFXANK	141	O14593
LLDFPPLFWVLDAHA	PGAP3	271	Q96FM1
LWDGLPRHFIIQSLD	FES	496	P07332
DADDRLLLAWPLEGL	MIEF2	311	Q96C03
IVFDLLDIPLYHGWL	MINDY2	356	Q8NBR6
PLEDLRLRLDHLGWV	RTN2	136	O75298
PLEEWLRLHTYLAGE	VARS1	141	P26640
LEGHRELSPLWLLAE	STK11IP	266	Q8N1F8
RDLFTPHFRWTTLLL	SVOP	306	Q8N4V2
WLPLHVFNLLRDLDP	PRLHR	291	P49683
PALWSLLHFRSLTEL	FBXL22	46	Q6P050
GWVPLLLALLHELQA	SETD6	121	Q8TBK2
ELLPHGRLEELWASF	TELO2	76	Q9Y4R8
ILRALELEHPAAWLL	CCT8L1P	76	A6NM43
ILRALELEHPAAWLL	CCT8L2	76	Q96SF2
VLLRGLLAALLGHWE	INTS5	876	Q6P9B9
LLLLSVWGFLREHGP	INTS5	941	Q6P9B9
VAILRHPTLEGWFLA	URB1	1011	O60287
GLGFLLLLLPEEWDV	SLC35F3	366	Q8IY50
WAIHLSGLDDLLLFL	TIMELESS	191	Q9UNS1
LVWRLGPTHFLEEVL	WDFY3	1261	Q8IZQ1
VLFDLLLAEWHLPAP	TRPM5	51	Q9NZQ8
DFPQHLRHLLGDWLE	STAT6	21	P42226
PGEHFWLLLLTRGLV	SPNS1	146	Q9H2V7
HLAPLWPFLGILAEI	NPTN	336	Q9Y639
RLFLLLWHPALGAQA	TUG1	26	A0A6I8PU40
KLGPDWFLLLLQGHL	WDFY4	1621	Q6ZS81
PGVFEDLHRLEWLII	RXFP1	191	Q9HBX9
AVLGLLLLRWQFPAH	MPL	506	P40238
PLHKIFHLWDTLLLG	TBCK	636	Q8TEA7
HWLFELLLESPLSGE	PSME4	1441	Q14997
LPHLGPILVWLFTRD	TSPO2	11	Q5TGU0
EGPREYVLHLWNLLD	TRPC7	461	Q9HCX4
WRSLLHLTFLIGFAP	nan	66	Q8TCH9
PLWARVGDDHLLLLQ	KLK10	91	O43240
PARLLNLDLDLWVHL	KMT2D	5046	O14686