Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	positive regulation of glucokinase activity	RGPD2 RANBP2	7.82e-05	9	31	2	GO:0033133
GeneOntologyBiologicalProcess	positive regulation of hexokinase activity	RGPD2 RANBP2	9.76e-05	10	31	2	GO:1903301
GeneOntologyBiologicalProcess	regulation of glucokinase activity	RGPD2 RANBP2	1.69e-04	13	31	2	GO:0033131
GeneOntologyBiologicalProcess	regulation of hexokinase activity	RGPD2 RANBP2	1.97e-04	14	31	2	GO:1903299
GeneOntologyCellularComponent	cytoplasmic periphery of the nuclear pore complex	RGPD2 RANBP2	5.93e-05	8	31	2	GO:1990723
GeneOntologyCellularComponent	nuclear pore cytoplasmic filaments	RGPD2 RANBP2	9.51e-05	10	31	2	GO:0044614
GeneOntologyCellularComponent	annulate lamellae	RGPD2 RANBP2	1.92e-04	14	31	2	GO:0005642
GeneOntologyCellularComponent	nuclear pore nuclear basket	RGPD2 RANBP2	3.21e-04	18	31	2	GO:0044615
GeneOntologyCellularComponent	nuclear inclusion body	RGPD2 RANBP2	3.98e-04	20	31	2	GO:0042405
GeneOntologyCellularComponent	SUMO ligase complex	RGPD2 RANBP2	4.39e-04	21	31	2	GO:0106068
Domain	Ran_BP1	RGPD2 RANBP2	1.63e-04	12	30	2	PF00638
Domain	TIL	FCGBP SSPOP	1.63e-04	12	30	2	PF01826
Domain	C8	FCGBP SSPOP	1.63e-04	12	30	2	PF08742
Domain	RANBD1	RGPD2 RANBP2	1.63e-04	12	30	2	PS50196
Domain	Unchr_dom_Cys-rich	FCGBP SSPOP	1.92e-04	13	30	2	IPR014853
Domain	RanBD	RGPD2 RANBP2	1.92e-04	13	30	2	SM00160
Domain	C8	FCGBP SSPOP	1.92e-04	13	30	2	SM00832
Domain	Ran_bind_dom	RGPD2 RANBP2	1.92e-04	13	30	2	IPR000156
Domain	TIL_dom	FCGBP SSPOP	2.24e-04	14	30	2	IPR002919
Domain	PHD	PHF14 CHD4 BAZ2B	2.34e-04	75	30	3	PF00628
Domain	Znf_PHD-finger	PHF14 CHD4 BAZ2B	2.72e-04	79	30	3	IPR019787
Domain	VWFD	FCGBP SSPOP	2.95e-04	16	30	2	PS51233
Domain	VWD	FCGBP SSPOP	2.95e-04	16	30	2	SM00216
Domain	VWF_type-D	FCGBP SSPOP	2.95e-04	16	30	2	IPR001846
Domain	VWD	FCGBP SSPOP	2.95e-04	16	30	2	PF00094
Domain	PHD	PHF14 CHD4 BAZ2B	3.87e-04	89	30	3	SM00249
Domain	Znf_PHD	PHF14 CHD4 BAZ2B	4.13e-04	91	30	3	IPR001965
Domain	VWC_out	FCGBP SSPOP	4.19e-04	19	30	2	SM00215
Domain	ZF_PHD_2	PHF14 CHD4 BAZ2B	4.69e-04	95	30	3	PS50016
Domain	ZF_PHD_1	PHF14 CHD4 BAZ2B	4.83e-04	96	30	3	PS01359
Domain	Znf_FYVE_PHD	PHF14 CHD4 BAZ2B	1.66e-03	147	30	3	IPR011011
Domain	VWC	FCGBP SSPOP	1.69e-03	38	30	2	SM00214
Domain	VWF_dom	FCGBP SSPOP	2.06e-03	42	30	2	IPR001007
Domain	SAM_2	DGKH WDSUB1	2.16e-03	43	30	2	PF07647
Domain	C1_1	DGKH KSR2	3.77e-03	57	30	2	PF00130
Domain	ZF_DAG_PE_1	DGKH KSR2	4.73e-03	64	30	2	PS00479
Domain	ZF_DAG_PE_2	DGKH KSR2	4.73e-03	64	30	2	PS50081
Domain	Zinc_finger_PHD-type_CS	PHF14 CHD4	4.87e-03	65	30	2	IPR019786
Domain	C1	DGKH KSR2	4.87e-03	65	30	2	SM00109
Domain	PE/DAG-bd	DGKH KSR2	5.02e-03	66	30	2	IPR002219
Domain	-	PHF14 CHD4 WDSUB1 BAZ2B	5.50e-03	449	30	4	3.30.40.10
Domain	Znf_RING/FYVE/PHD	PHF14 CHD4 WDSUB1 BAZ2B	5.95e-03	459	30	4	IPR013083
Domain	EGF_1	LAMB1 ADAM2 SSPOP	7.78e-03	255	30	3	PS00022
Domain	EGF_2	LAMB1 ADAM2 SSPOP	8.64e-03	265	30	3	PS01186
Domain	SAM	DGKH WDSUB1	8.76e-03	88	30	2	SM00454
Domain	Galactose-bd-like	LAMB1 SSPOP	9.95e-03	94	30	2	IPR008979
Domain	SAM_DOMAIN	DGKH WDSUB1	1.02e-02	95	30	2	PS50105
Domain	SAM	DGKH WDSUB1	1.06e-02	97	30	2	IPR001660
Pathway	PID_HDAC_CLASSI_PATHWAY	RANBP2 CHD4 SSPOP	7.61e-05	66	18	3	M101
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	PHF14 RANBP2 CHD4 MDN1	1.09e-05	150	32	4	28242625
Pubmed	Systematic identification of factors for provirus silencing in embryonic stem cells.	RGPD2 RANBP2 CHD4 MDN1	1.18e-05	153	32	4	26365490
Pubmed	Retina-specifically expressed novel subtypes of bovine cyclophilin.	RGPD2 RANBP2	1.72e-05	7	32	2	7559465
Pubmed	Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.	RGPD2 RANBP2	1.72e-05	7	32	2	30944974
Pubmed	Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.	RGPD2 RANBP2	1.72e-05	7	32	2	38838144
Pubmed	Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.	RGPD2 RANBP2	1.72e-05	7	32	2	21205196
Pubmed	Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).	RGPD2 RANBP2	1.72e-05	7	32	2	26632511
Pubmed	Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.	RGPD2 RANBP2	1.72e-05	7	32	2	17372272
Pubmed	Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.	RGPD2 RANBP2	1.72e-05	7	32	2	24403063
Pubmed	Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.	RGPD2 RANBP2	1.72e-05	7	32	2	18949001
Pubmed	Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.	RGPD2 RANBP2	1.72e-05	7	32	2	23818861
Pubmed	Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.	RGPD2 RANBP2	1.72e-05	7	32	2	38657106
Pubmed	Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.	RGPD2 RANBP2	1.72e-05	7	32	2	11353387
Pubmed	Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.	RGPD2 RANBP2	1.72e-05	7	32	2	25187515
Pubmed	Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.	RGPD2 RANBP2	1.72e-05	7	32	2	9037092
Pubmed	Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.	RGPD2 RANBP2	1.72e-05	7	32	2	23536549
Pubmed	Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.	RGPD2 RANBP2	1.72e-05	7	32	2	12191015
Pubmed	Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).	RGPD2 RANBP2	1.72e-05	7	32	2	22821000
Pubmed	Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.	RGPD2 RANBP2	1.72e-05	7	32	2	8603673
Pubmed	Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.	RGPD2 RANBP2	1.72e-05	7	32	2	20682751
Pubmed	Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.	DGKH DKK3 SORCS1	1.90e-05	56	32	3	23934736
Pubmed	The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.	RGPD2 RANBP2	2.29e-05	8	32	2	22262462
Pubmed	The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.	RGPD2 RANBP2	2.29e-05	8	32	2	21670213
Pubmed	Reptilian heart development and the molecular basis of cardiac chamber evolution.	BMP10 DKK3	2.29e-05	8	32	2	19727199
Pubmed	Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.	RGPD2 RANBP2	2.29e-05	8	32	2	28745977
Pubmed	Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.	RGPD2 RANBP2	2.29e-05	8	32	2	27412403
Pubmed	Mice lacking Ran binding protein 1 are viable and show male infertility.	RGPD2 RANBP2	2.29e-05	8	32	2	21310149
Pubmed	Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.	RGPD2 RANBP2	2.94e-05	9	32	2	18394993
Pubmed	Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.	RGPD2 RANBP2	2.94e-05	9	32	2	28877029
Pubmed	The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.	RGPD2 RANBP2	2.94e-05	9	32	2	11553612
Pubmed	The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.	RGPD2 RANBP2	2.94e-05	9	32	2	9733766
Pubmed	Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.	RGPD2 RANBP2	2.94e-05	9	32	2	17887960
Pubmed	The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.	RGPD2 RANBP2	2.94e-05	9	32	2	10601307
Pubmed	Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.	RGPD2 RANBP2	2.94e-05	9	32	2	28100513
Pubmed	Parkin ubiquitinates and promotes the degradation of RanBP2.	RGPD2 RANBP2	3.67e-05	10	32	2	16332688
Pubmed	The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.	RGPD2 RANBP2	3.67e-05	10	32	2	27160050
Pubmed	Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.	RGPD2 RANBP2	3.67e-05	10	32	2	8857542
Pubmed	Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.	RGPD2 RANBP2	3.67e-05	10	32	2	21859863
Pubmed	An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.	RGPD2 RANBP2	4.49e-05	11	32	2	35771867
Pubmed	Missense Mutation in Human CHD4 Causes Ventricular Noncompaction by Repressing ADAMTS1.	CHD4 BMP10	4.49e-05	11	32	2	37254794
Pubmed	The HAND1 frameshift A126FS mutation does not cause hypoplastic left heart syndrome in mice.	BMP10 DKK3	4.49e-05	11	32	2	29016838
Pubmed	RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.	RGPD2 RANBP2	4.49e-05	11	32	2	17069463
Pubmed	T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.	RGPD2 RANBP2	4.49e-05	11	32	2	34110283
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	PHF14 DGKH MDN1 SSPOP BAZ2B CEP95	4.99e-05	736	32	6	29676528
Pubmed	Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.	RGPD2 RANBP2	6.36e-05	13	32	2	31427429
Pubmed	A human MAP kinase interactome.	KIAA1328 LAMB1 RANBP2 ZNF142 CEP95	7.70e-05	486	32	5	20936779
Pubmed	Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung.	FZD2 DKK3	8.55e-05	15	32	2	15617677
Pubmed	Hand factor ablation causes defective left ventricular chamber development and compromised adult cardiac function.	BMP10 DKK3	8.55e-05	15	32	2	28732025
Pubmed	Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.	RGPD2 RANBP2	8.55e-05	15	32	2	14697343
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	RGPD2 PHF14 RANBP2 CHD4	1.09e-04	271	32	4	32433965
Pubmed	Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.	DGKH FZD2	1.24e-04	18	32	2	19308021
Pubmed	Genome-wide association study link novel loci to endometriosis.	KSR2 SORCS1	1.39e-04	19	32	2	23472165
Pubmed	Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.	RGPD2 RANBP2	1.87e-04	22	32	2	27717094
Pubmed	β1 integrins regulate cellular behaviour and cardiomyocyte organization during ventricular wall formation.	LAMB1 BMP10	1.87e-04	22	32	2	38794925
Pubmed	A role for Wnt/beta-catenin signaling in lens epithelial differentiation.	FZD2 DKK3	2.43e-04	25	32	2	12812787
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	RANBP2 MDN1 BAZ2B C6orf132	2.60e-04	340	32	4	29478914
Pubmed	Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells.	RGPD2 RANBP2 CHD4	2.61e-04	135	32	3	31077711
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	RGPD2 RANBP2 CHD4	3.29e-04	146	32	3	23892456
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	KIAA1328 PHF14 DGKH DOCK6 MBNL2 SSPOP KSR2	3.41e-04	1489	32	7	28611215
Pubmed	Identification of molecules preferentially expressed beneath the marginal zone in the developing cerebral cortex.	LAMB1 CHD4	3.51e-04	30	32	2	18055048
Pubmed	Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages.	ITPKC BAZ2B	4.00e-04	32	32	2	26142281
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	RANBP2 CHD4 MDN1 DOCK6	4.76e-04	399	32	4	37536630
Pubmed	Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation.	FZD2 DKK3	5.07e-04	36	32	2	12412008
Pubmed	Peering through the pore: nuclear pore complex structure, assembly, and function.	RGPD2 RANBP2	5.65e-04	38	32	2	12791264
Pubmed	Cdx and T Brachyury Co-activate Growth Signaling in the Embryonic Axial Progenitor Niche.	FZD2 DKK3	6.26e-04	40	32	2	28009287
Pubmed	The conserved Tpk1 regulates non-homologous end joining double-strand break repair by phosphorylation of Nej1, a homolog of the human XLF.	RANBP2 CHD4	6.90e-04	42	32	2	34244791
Pubmed	Generation and annotation of the DNA sequences of human chromosomes 2 and 4.	RGPD2 RANBP2 BMP10 WDSUB1	6.98e-04	442	32	4	15815621
Pubmed	Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.	ADAD2 DKK3 KSR2	7.41e-04	193	32	3	22589738
Pubmed	Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.	FZD2 DKK3	8.64e-04	47	32	2	28813421
Pubmed	Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos.	FZD2 DKK3	8.64e-04	47	32	2	18351675
Cytoband	2q24.2	WDSUB1 BAZ2B	1.08e-04	22	32	2	2q24.2
Cytoband	19q13.1	ITPKC FCGBP	6.83e-04	55	32	2	19q13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr2q24	WDSUB1 BAZ2B	3.57e-03	127	32	2	chr2q24
GeneFamily	PHD finger proteins	PHF14 CHD4 BAZ2B	1.72e-04	90	22	3	88
GeneFamily	Sterile alpha motif domain containing	DGKH WDSUB1	5.08e-03	88	22	2	760
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	RGPD2 RANBP2	8.53e-03	115	22	2	769
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	LAMB1 BAZ2B DKK3 SORCS1	1.21e-05	199	32	4	38cfd367ee8c074c11ba54edeb7a001e375e2687
ToppCell	Parenchyma_Control_(B.)-Stromal-TX-Smooth_muscle-1\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	LAMB1 DGKH DOCK6 DKK3	1.24e-05	200	32	4	0c648941447c738caf62f2d71e296d6cca492c8b
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Smooth_muscle-1\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	LAMB1 DGKH DOCK6 DKK3	1.24e-05	200	32	4	94f1fa61aa82eb9f411b2b1cb759476939ab5db7
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Smooth_muscle-1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LAMB1 DGKH DOCK6 DKK3	1.24e-05	200	32	4	522a51a284d2992d519c4669e1a48c8ebcc08c80
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	LAMB1 BAZ2B DKK3 SORCS1	1.24e-05	200	32	4	09537dc25f8b8b4654a7c183827ee1522a41a4e0
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-mature_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA1328 DGKH DOCK6	1.31e-04	138	32	3	321070b6900887b27da0f2b25808a05a8ab89ee7
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-BM_CD8_+_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA1328 DGKH DOCK6	1.31e-04	138	32	3	19ffd66256fa94d728138d37d0a5a3bac7722dbb
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Rectal_Adenocarcinoma\|TCGA-Colorectal / Sample_Type by Project: Shred V9	ADAM2 FCGBP KSR2	1.31e-04	138	32	3	e1e936ff4080bda2810c5fd1154a706359f377a5
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_1\|368C / Donor, Lineage, Cell class and subclass (all cells)	KIAA1328 RGPD2 DGKH	1.61e-04	148	32	3	80470353e12599440f711b6e107730763376d04d
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	RGPD2 MDN1 SORCS1	1.81e-04	154	32	3	ec920cae12ea1d14b6c973f6e903f895f80e3c50
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.1.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RGPD2 FCGBP WDR97	2.30e-04	167	32	3	8fede587572d465cb63f7828141a574185bbb819
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	KIAA1328 FZD2 SSPOP	2.38e-04	169	32	3	ea600c63cf9572bc4b3cad6392f67bd0d92c7fc9
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB1 FCGBP PKD1L3	2.43e-04	170	32	3	a121e10099faaeb60251eec162f38caf7c4238c2
ToppCell	Nasal_Brush-Epithelial-Basal_1\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	LAMB1 ZNF668 DKK3	2.51e-04	172	32	3	4483073469001770015526303772fd54906c5d68
ToppCell	Nasal_Brush-Epithelial-Basal_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	LAMB1 ZNF668 DKK3	2.51e-04	172	32	3	58eaadf12366701103a0d1f133462c9495fedc30
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	KIAA1328 RGPD2 DGKH	2.60e-04	174	32	3	58300d64d3b6fd9ba1b6c87ea83b2777eb6be2f4
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FCGBP MDN1 CEP95	2.64e-04	175	32	3	dbd9dac129fb6ae5f55e7b96d04b37585458dc4a
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB1 FCGBP PKD1L3	2.64e-04	175	32	3	f7cd2ef79d91d64976fcdb5f1e7343b24ba27456
ToppCell	droplet-Limb_Muscle-nan-21m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DGKH FZD2 C6orf132	2.73e-04	177	32	3	291231b1520c135e92739e201495fe1935efa927
ToppCell	5'-Adult-Distal_Rectal-Epithelial-goblet-Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF142 FCGBP KSR2	2.73e-04	177	32	3	e1e45956887371b1c18f1eb479dd930031497520
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LAMB1 DGKH DOCK6	2.78e-04	178	32	3	185b44700f06ec58b3c09c80520502166c965fd6
ToppCell	wk_15-18-Mesenchymal-Chondrocyte-ASPN+_chondrocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	RGPD2 ITPKC CEP95	2.78e-04	178	32	3	a55130670aa95a87b833dd3cd2de461d779e4c06
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ITPKC DGKH BAZ2B	2.82e-04	179	32	3	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L2-3_LINC00507_RPL9P17\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LAMB1 MBNL2 SORCS1	2.82e-04	179	32	3	9ba8693fba2175bca9ff9735cc04e657abeb9084
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LAMB1 DOCK6 DKK3	2.82e-04	179	32	3	56db12467b445f2b8ef92af50779eeab10413eb2
ToppCell	MS-Treg-naive_CD4\|MS / Condition, Cell_class and T cell subcluster	DGKH PIK3CD C6orf132	2.87e-04	180	32	3	7ca083616926d98420fa11a6e5ebc981623f79ac
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	RANBP2 DGKH MBNL2	2.91e-04	181	32	3	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	Children_(3_yrs)-Immune-enucleated_erythrocyte-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CEP95 DKK3 C6orf132	2.96e-04	182	32	3	3fddadb2ff75013ec6eeb415872667a6bae1da2d
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LAMB1 DGKH DKK3	3.01e-04	183	32	3	8a799807fbf24456a9811e0c64068187940a2f71
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	LAMB1 DGKH DOCK6	3.11e-04	185	32	3	a7dba7db79275884b2a93d8a16f2e0c739e71370
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAMB1 DKK3 SORCS1	3.16e-04	186	32	3	6f88b68735d0f7c9904eb8413e6007910d556185
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMB1 DGKH DOCK6	3.16e-04	186	32	3	888e85a025bd982d36c910db0f5a3385b1ca3b28
ToppCell	droplet-Bladder-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RANBP2 CHD4 MBNL2	3.21e-04	187	32	3	663991a8afe652e92363b64bcbd68c14d0307f0e
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	LAMB1 DGKH DOCK6	3.21e-04	187	32	3	a2bf958ea59c359a265bfa437d59315e1920cdd4
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LAMB1 DGKH DOCK6	3.26e-04	188	32	3	ee151792c7ac9afe820f1a281c6dab383799f358
ToppCell	343B-Lymphocytic-ILC\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	KIAA1328 DGKH CHD4	3.31e-04	189	32	3	c26428871dc3261327d89cacaba6e21e004ff1f3
ToppCell	Mesenchymal-pericyte_cell\|World / Lineage, Cell type, age group and donor	LAMB1 DGKH DOCK6	3.31e-04	189	32	3	d7ed96add29f219183c802895fbff519b627f635
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Epcam____podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGBP DKK3 SORCS1	3.31e-04	189	32	3	319e42f6e2322208de78bc666fb2c074707eb4da
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_1-Pericyte\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	LAMB1 DGKH DOCK6	3.36e-04	190	32	3	4eb92aef1ee868f4537483d19014d947b7684612
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	LAMB1 DGKH DOCK6	3.36e-04	190	32	3	7be4341e2909101d756f14031c21e705eb45e69a
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25\|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)	RGPD2 RANBP2 MBNL2	3.41e-04	191	32	3	1ecd9849d14d5ebf3daf610e83fb50820cafd3ed
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LAMB1 FZD2 DKK3	3.46e-04	192	32	3	1b228f0929b505de82a39bf64c837887b0e56701
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LAMB1 FZD2 DKK3	3.46e-04	192	32	3	cdc652dbfabe41b324fd85c1ed933d29fb73a49f
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LAMB1 FZD2 DKK3	3.46e-04	192	32	3	29bee88b45e23f16543ffc7cc361bc5da5d16a2b
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child\|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)	RGPD2 RANBP2 MBNL2	3.46e-04	192	32	3	aee6522d25e012231cdb905ce047295cb64d6e82
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LAMB1 FZD2 DKK3	3.52e-04	193	32	3	9d0b966d13cbce97beb43de6dc77f006c363a181
ToppCell	facs-Lung-nan-3m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB1 FZD2 DKK3	3.52e-04	193	32	3	d9c20a092b507c43fcf7ccb04073fecd27d1749c
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LAMB1 FZD2 DKK3	3.52e-04	193	32	3	fe9720185929ef849edd1b8eb4854306b392e5a2
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ITPKC C6orf132 KSR2	3.52e-04	193	32	3	a5695ce2e24a62026ae28f3dea07ca4a435206b8
ToppCell	RA\|World / Chamber and Cluster_Paper	BMP10 DKK3 SORCS1	3.57e-04	194	32	3	08f0afbb68a63150fbe107a5337299081c3f69e4
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DGKH DOCK6 BAZ2B	3.57e-04	194	32	3	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LAMB1 FZD2 DKK3	3.57e-04	194	32	3	7826fe5eb254ac032de0d978f39585a40e0b3ee4
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	DGKH FCGBP SORCS1	3.62e-04	195	32	3	633c7668fe365f7b0f7851cdc442d5dd89c454e2
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-IPC/newborn-38\|World / Primary Cells by Cluster	PHF14 FCGBP BAZ2B	3.68e-04	196	32	3	38da0751941adca650fe9b383d9f343153978eb5
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-IPC/newborn\|World / Primary Cells by Cluster	PHF14 FCGBP BAZ2B	3.68e-04	196	32	3	721650a08d260faf530dbd52d4e9275d27f3bac2
ToppCell	PND28-Mesenchymal\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LAMB1 FZD2 DKK3	3.68e-04	196	32	3	119265efd2219f328d8152dbee52af8327aec89c
ToppCell	LPS_IL1RA_TNF\|World / Treatment groups by lineage, cell group, cell type	LAMB1 FZD2 DKK3	3.73e-04	197	32	3	0a6550dce156fc81f15b1e7830d331ca50d87d06
ToppCell	Tracheal-10x5prime-Stromal-Peri/Epineurial_\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	LAMB1 FZD2 DKK3	3.73e-04	197	32	3	2cb1f557ce1400398975de94638126b4522567f3
ToppCell	10x3'2.3-week_17-19-Endothelial-stroma-tip_EC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	LAMB1 DGKH DOCK6	3.73e-04	197	32	3	b212ff28ca2d1fea4140f186ab90941bdca21249
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-squamous_epithelial_cell-Epi-Squamous\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ITPKC FCGBP C6orf132	3.79e-04	198	32	3	72d91bd0c727ecadc41e023a16c9326158db1b7b
ToppCell	Tracheal-10x5prime-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK6 SSPOP DKK3	3.79e-04	198	32	3	306e28d31fd587409a12dcccc6b2abd7dc9c2e0a
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-squamous_epithelial_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ITPKC FCGBP C6orf132	3.79e-04	198	32	3	441608034c787e55691558a480dcd07e37419138
ToppCell	10x3'2.3-week_17-19-Endothelial-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	LAMB1 DGKH DOCK6	3.79e-04	198	32	3	1e83bec16dcd60460422625f89952ff506d6be51
ToppCell	10x3'2.3-week_17-19-Endothelial\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	LAMB1 DGKH DOCK6	3.79e-04	198	32	3	2630a7a6e56febe5c0b0bde70dd7292fa1650c47
ToppCell	Tracheal-10x5prime-Endothelial-Endothelia_lymphatic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK6 SSPOP DKK3	3.79e-04	198	32	3	05429f18e1d74880c1835568c86177f661b3477a
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DGKH DOCK6 BAZ2B	3.90e-04	200	32	3	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DGKH DOCK6 BAZ2B	3.90e-04	200	32	3	a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Mesenchymal-Mesoderm\|5w / Sample Type, Dataset, Time_group, and Cell type.	ITPKC DGKH ZNF142	3.90e-04	200	32	3	0927061536a664b4f7feb9e5b0a8c11ca0d5955c
ToppCell	LPS_IL1RA-Epithelial_airway-airway_epithelial-Airway-Club\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ADAM2 FCGBP C6orf132	3.90e-04	200	32	3	df90b67490cd649de3e3a713762ffbc34a698899
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_only / Treatment groups by lineage, cell group, cell type	FZD2 BAZ2B DKK3	3.90e-04	200	32	3	a9ff3210127000b3dd9e97136163c98c2b0817d7
ToppCell	Parenchymal-10x3prime_v2-Stromal-Fibroblastic-Fibro_peribronchial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	LAMB1 DKK3 SORCS1	3.90e-04	200	32	3	efdf7066b7dd43e35dbc0d2719b75f250cf54af2
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|Control_saline / Treatment groups by lineage, cell group, cell type	LAMB1 DKK3 SORCS1	3.90e-04	200	32	3	a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAMB1 PHF14 BAZ2B	3.90e-04	200	32	3	ac8a5d71acd4d401995babd233f0d3738e8ad2a5
Disease	ferritin measurement	KIAA1328 WDSUB1 BAZ2B	2.65e-04	119	31	3	EFO_0004459
Disease	colorectal cancer (is_implicated_in)	ITPKC CHD4 PIK3CD	2.78e-04	121	31	3	DOID:9256 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LKPVCYVAPSLCDTH	ADAD2	376	Q8NCV1
KHCHCSASYLPPDCS	ADAM2	631	Q99965
CHTYCHRPKITTIPD	BAZ2B	1956	Q9UIF8
HHSSYQPLCLPLPVC	RANBP2	506	P49792
LLTHLYSHLKCSPLC	ITPKC	311	Q96DU7
ILHKRCSLPPSYCSK	MDN1	1231	Q9NU22
VPSKCVQHYCHTSPT	KSR2	201	Q6VAB6
KCLPFCHSNVLSHSY	OR51H1	166	Q8NH63
SQHCKSLAIPCPAHY	FZD2	496	Q14332
CGLHKPEPYCIVSHL	LAMB1	56	P07942
VHTACKDLYHPICPL	DGKH	286	Q86XP1
NHFYCDTPPLLKLSC	OR5AP2	181	Q8NGF4
CKLHYHLGCLDPPLT	PHF14	746	O94880
QHPKTHPESCSYCRL	KIAA1328	326	Q86T90
PCLYKPHCHQSSLSR	C6orf132	766	Q5T0Z8
CNYPLAEHLTPTKHA	BMP10	356	O95393
HEHYVTLNLPCCPLS	DOCK6	1051	Q96HP0
LCPLSCPPHSHYEAC	FCGBP	1131	Q9Y6R7
CPIGKEYLHSSHCSP	CEP95	276	Q96GE4
CSRENCKYLHPPTHL	MBNL2	61	Q5VZF2
TCPSSYHIHCLNPPL	CHD4	466	Q14839
LLCQPHSHSLVYVCK	DKK3	271	Q9UBP4
CLHNLTAHCSPYCPL	SSPOP	1991	A2VEC9
SCGRHHCPHLPTKIY	SAXO1	11	Q8IYX7
HHSSYQPLCLPLPVC	RGPD2	506	P0DJD1
TCHYPLPAHLSKTLC	PKD1L3	186	Q7Z443
HSSVRPYTCPHCPKA	ZNF668	566	Q96K58
APQPCCLHLYSHLTD	WDR97	521	A6NE52
YICSCLHSGLTPHLT	PIK3CD	261	O00329
HDKTPTHFCPLCDYS	ZNF142	1251	P52746
PHSPLKFHTYAVHCC	WDSUB1	46	Q8N9V3
VHCLLPYCSLHLHLK	SORCS1	516	Q8WY21
PYCSLHLHLKVSENP	SORCS1	521	Q8WY21